HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$197+ Cheap flights from Syracuse to Knoxville (SYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/6. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — TYS
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Syracuse to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Syracuse to Knoxville

Cheapest flights from Syracuse to Knoxville
Explore the most affordable flight options available from Syracuse to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:37 pm
SYR
-
TYS
1 stop5h 15m
Delta
Wed 2/255:02 pm
TYS
-
SYR
1 stop6h 10m
Delta
Deal found 1/21$251
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:36 pm
SYR
-
TYS
1 stop25h 12m
Allegiant Air
Thu 4/309:25 pm
TYS
-
SYR
1 stop13h 16m
Allegiant Air
Deal found 1/20$263
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:00 am
SYR
-
TYS
1 stop4h 06m
Delta
Tue 4/286:00 am
TYS
-
SYR
1 stop5h 55m
Delta
Deal found 1/20$269
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:00 am
SYR
-
TYS
1 stop4h 06m
Delta
Tue 4/285:40 pm
TYS
-
SYR
1 stop6h 19m
Delta
Deal found 1/21$274
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/112:15 pm
SYR
-
TYS
2 stops7h 29m
American Airlines
Mon 2/166:05 am
TYS
-
SYR
1 stop5h 34m
American Airlines
Deal found 1/20$276
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:34 pm
SYR
-
TYS
1 stop5h 20m
Delta
Thu 5/76:10 am
TYS
-
SYR
1 stop4h 59m
Delta
Deal found 1/20$279
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:12 pm
SYR
-
TYS
1 stop6h 33m
United Airlines
Sat 5/97:00 am
TYS
-
SYR
1 stop6h 25m
United Airlines
Deal found 1/20$285
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1812:19 pm
SYR
-
TYS
2 stops8h 21m
American Airlines
Wed 2/256:10 am
TYS
-
SYR
1 stop5h 43m
American Airlines
Deal found 1/21$290
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:00 am
SYR
-
TYS
1 stop7h 18m
American Airlines
Thu 7/26:21 am
TYS
-
SYR
1 stop4h 03m
American Airlines
Deal found 1/20$291
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:36 am
SYR
-
TYS
1 stop6h 16m
United Airlines
Tue 5/57:00 am
TYS
-
SYR
2 stops7h 14m
United Airlines
Deal found 1/21$294

Find flight deals from Syracuse to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$251
(Delta)

One-way from

$197
(Kiwi.com)

Popular in

August

Cheapest in

May

Average price

$301
Provider with most accurate pricing for Syracuse Hancock Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Knoxville McGhee Tyson flights.
Search Deals
From Syracuse Hancock Intl to Knoxville McGhee Tyson
Search Deals
One-way flight from Syracuse Hancock Intl to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($11 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Syracuse to Knoxville that are best for you.

Fly from

Syracuse

Fly to

Knoxville

Route

Depart

Return

Price

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 2/18

6:37 pm-11:52 pm

1 stop5h 15m

Knoxville McGhee Tyson

Wed 2/25

5:02 pm-11:12 pm

1 stop6h 10m

$251

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 5/5

6:00 am-10:06 am

1 stop4h 06m

Knoxville McGhee Tyson

Wed 5/13

6:10 am-11:09 am

1 stop4h 59m

$269

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 4/29

6:00 am-11:45 am

1 stop5h 45m

Knoxville McGhee Tyson

Tue 5/5

5:30 pm-11:09 pm

1 stop5h 39m

$269

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 4/15

6:00 am-10:06 am

1 stop4h 06m

Knoxville McGhee Tyson

Wed 4/22

5:35 pm-11:16 pm

1 stop5h 41m

$269

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 5/4

6:00 am-10:06 am

1 stop4h 06m

Knoxville McGhee Tyson

Mon 5/11

7:20 pm-11:59 pm

1 stop4h 39m

$269

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 4/20

6:00 am-10:06 am

1 stop4h 06m

Knoxville McGhee Tyson

Thu 4/30

5:30 pm-11:09 pm

1 stop5h 39m

$269

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 5/5

6:00 am-11:45 am

1 stop5h 45m

Knoxville McGhee Tyson

Mon 5/11

7:20 pm-11:59 pm

1 stop4h 39m

$269

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Mon 4/20

6:00 am-10:06 am

1 stop4h 06m

Knoxville McGhee Tyson

Tue 4/28

5:35 pm-11:16 pm

1 stop5h 41m

$269

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Wed 4/29

6:00 am-10:06 am

1 stop4h 06m

Knoxville McGhee Tyson

Wed 5/6

6:00 am-11:55 am

1 stop5h 55m

$269

SyracuseKnoxville

SYR - TYS

SYRTYS

Syracuse Hancock Intl

Tue 4/28

6:00 am-10:06 am

1 stop4h 06m

Knoxville McGhee Tyson

Tue 5/5

5:30 pm-11:09 pm

1 stop5h 39m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

Showing 1-10 of 22 results
1
2
3

Compare providers for flights from Syracuse to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Syracuse-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Syracuse-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Syracuse to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Knoxville

How far ahead should I book a flight from Syracuse to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Syracuse to Knoxville. Price data was last updated on January 16, 2026.

Booking 89 days in advance of your planned departure date is, on average, the best time to get cheap flights from Syracuse to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Syracuse to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Syracuse to Knoxville (average of $137). Flying from Syracuse to Knoxville in December is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 21, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Syracuse to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,089 reviews
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,191 reviews
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,174 reviews
Delta
7.9
Good
8,089 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Syracuse to Knoxville?

    For as low as $251, Delta can have you in Knoxville from Syracuse in 5h 15m. Syracuse and Knoxville are separated by a distance of 656 mi.

  • What are the cheapest airlines flying from Syracuse to Knoxville round-trip?

    Our cheapest airline available from Syracuse to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $223 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $232 and $293 round-trip. American Airlines is currently priced 35% below the average price you’ll pay for this route.

  • Can I find deals for flights from Syracuse to Knoxville that include hotel bookings?

    Yes. In addition to deals on Syracuse to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Knoxville.

  • Can I find deals for business class flights from Syracuse to Knoxville?

    Yes. Cheapflights offers flight deals from Syracuse to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Syracuse to Knoxville (average of $137). Flying from Syracuse to Knoxville in December is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Syracuse to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Newark to Nashville flights
John F Kennedy Intl to Nashville flights
LaGuardia to Nashville flights
LaGuardia to Knoxville flights
John F Kennedy Intl to Knoxville flights
LaGuardia to Memphis flights
Albany to Nashville flights
John F Kennedy Intl to Memphis flights
Newark to Memphis flights
Buffalo to Nashville flights
White Plains to Nashville flights
Stewart to Nashville flights
Syracuse to Nashville flights
Newark to Knoxville flights
Newark to Chattanooga flights
LaGuardia to Chattanooga flights
John F Kennedy Intl to Chattanooga flights
Rochester to Nashville flights
Islip to Nashville flights
Stewart to Knoxville flights
Rochester to Knoxville flights
Buffalo to Knoxville flights
Buffalo to Memphis flights
Ithaca to Nashville flights
Albany to Knoxville flights
Syracuse to Chattanooga flights
Syracuse to Memphis flights
White Plains to Knoxville flights
Binghamton to Nashville flights
Albany to Memphis flights
Stewart to Memphis flights
Elmira to Nashville flights
Rochester to Memphis flights
John F Kennedy Intl to Blountville flights
Albany to Chattanooga flights
White Plains to Chattanooga flights
LaGuardia to Blountville flights
Newark to Blountville flights
Syracuse to Blountville flights
White Plains to Memphis flights
Plattsburgh to Nashville flights
Buffalo to Chattanooga flights
Watertown to Nashville flights
Ithaca to Knoxville flights
Islip to Knoxville flights
Rochester to Chattanooga flights
Rutland to Nashville flights
Stewart to Chattanooga flights
Buffalo to Blountville flights

Top 3 airlines flying from Syracuse to Knoxville

Discover the top 3 airlines that operate flights from Syracuse to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$223Average$363FlexibilityNo cancel feeOn-time71%
DeltaCheapest$232Average$283FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$293Average$490FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.