HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Syracuse

$222+ Cheap flights from Knoxville to Syracuse (TYS - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SYR
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Syracuse with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Syracuse

Cheapest flights from Knoxville to Syracuse
Explore the most affordable flight options available from Knoxville to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/59:17 pm
TYS
-
SYR
1 stop13h 10m
Allegiant Air
Mon 6/2211:38 am
SYR
-
TYS
1 stop23h 28m
Allegiant Air
Deal found 3/10$272
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:10 am
TYS
-
SYR
1 stop4h 59m
Delta
Thu 7/163:11 pm
SYR
-
TYS
1 stop6h 33m
Delta
Deal found 3/6$289
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:12 pm
TYS
-
SYR
1 stop5h 22m
American Airlines
Mon 5/116:15 pm
SYR
-
TYS
1 stop4h 10m
American Airlines
Deal found 3/6$291
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:30 am
TYS
-
SYR
2 stops7h 39m
United Airlines
Sun 9/66:00 am
SYR
-
TYS
1 stop4h 36m
United Airlines
Deal found 3/8$294
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:02 pm
TYS
-
SYR
1 stop29h 34m
Allegiant Air
Sun 6/1410:25 am
SYR
-
TYS
1 stop11h 51m
Allegiant Air
Deal found 3/9$305
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/812:45 pm
TYS
-
SYR
1 stop6h 04m
Allegiant Air
Mon 5/117:39 pm
SYR
-
TYS
1 stop14h 01m
Allegiant Air
Deal found 3/10$344
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:15 am
TYS
-
SYR
1 stop11h 21m
Allegiant Air
Sun 6/287:26 pm
SYR
-
TYS
1 stop23h 06m
Allegiant Air
Deal found 3/6$358
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:05 am
TYS
-
SYR
1 stop5h 34m
American Airlines
Sat 3/216:00 am
SYR
-
TYS
1 stop5h 20m
American Airlines
Deal found 3/9$359
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:00 am
TYS
-
SYR
2 stops13h 22m
Multiple Airlines
Mon 6/2211:38 am
SYR
-
TYS
1 stop23h 28m
Multiple Airlines
Deal found 3/10$365
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:30 am
TYS
-
SYR
1 stop25h 26m
Multiple Airlines
Fri 4/36:07 pm
SYR
-
TYS
1 stop20h 02m
Multiple Airlines
Deal found 3/8$372

Find flight deals from Knoxville to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$272
(Kiwi.com)

One-way from

$222
(Kiwi.com)

Popular in

February

Cheapest in

April

Average price

$349
Provider with most accurate pricing for Knoxville McGhee Tyson-Syracuse Hancock Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Syracuse Hancock Intl flights.
Search Deals
From Knoxville McGhee Tyson to Syracuse Hancock Intl
Search Deals
One-way flight from Knoxville McGhee Tyson to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($110 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Knoxville to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 7/9

6:10 am-11:09 am

1 stop4h 59m

Syracuse Hancock Intl

Thu 7/16

3:11 pm-9:44 pm

1 stop6h 33m

$289

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 9/1

5:30 am-11:12 am

1 stop5h 42m

Syracuse Hancock Intl

Sun 9/6

6:18 am-10:59 am

1 stop4h 41m

$289

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 9/1

6:30 am-2:09 pm

2 stops7h 39m

Syracuse Hancock Intl

Sun 9/6

6:00 am-10:36 am

1 stop4h 36m

$294

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 6/10

1:02 pm-6:36 pm

1 stop29h 34m

Syracuse Hancock Intl

Sun 6/14

10:25 am-10:16 pm

1 stop11h 51m

$305

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 7/9

7:15 am-6:36 pm

1 stop11h 21m

Syracuse Hancock Intl

Thu 7/16

7:26 pm-10:00 pm

2 stops26h 34m

$397
Quickest round-trip

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 7/1

6:12 am-10:22 am

1 stop4h 10m

Syracuse Hancock Intl

Sun 7/5

7:43 pm-11:51 pm

1 stop4h 08m

$398

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sat 5/9

7:00 am-1:25 pm

1 stop6h 25m

Syracuse Hancock Intl

Mon 5/11

10:35 am-8:45 pm

2 stops10h 10m

$444

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 7/2

7:15 am-8:37 am

2 stops25h 22m

Syracuse Hancock Intl

Mon 7/6

7:31 pm-10:37 am

1 stop15h 06m

$449

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 4/3

6:05 am-12:00 pm

1 stop5h 55m

Syracuse Hancock Intl

Sun 4/5

5:50 am-10:31 am

1 stop4h 41m

$462

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Mon 3/23

6:05 am-11:39 am

1 stop5h 34m

Syracuse Hancock Intl

Wed 3/25

11:46 am-4:31 pm

1 stop4h 45m

$683

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/6

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Syracuse in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Syracuse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Syracuse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Syracuse flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Syracuse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Syracuse

What is the cheapest month to book a flight from Knoxville to Syracuse?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $160). Flying from Knoxville to Syracuse in March is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated March 10, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Syracuse. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,276 reviews

Overall

7.9

Comfort

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,276 reviews
Delta
7.9
Good
8,276 reviews

Overall

7.9

Comfort

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.1
Good
11,414 reviews
Delta
7.9
Good
8,276 reviews

Overall

7.9

Comfort

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Syracuse?

    Airlines like Delta, United Airlines, and Allegiant Air fly from Knoxville to Syracuse in about 4h 59m. The time it takes to get you to your destination can typically vary by up to 24h 35m. Knoxville and Syracuse are separated by a distance of 656 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Syracuse round-trip?

    According to our current data, American Airlines ($238), and Delta ($242) offers the cheapest pricing from Knoxville to Syracuse. You may be able to fly from Knoxville to Syracuse for 29% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Syracuse that include hotel bookings?

    Yes. In addition to deals on Knoxville to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Syracuse.

  • Can I find deals for business class flights from Knoxville to Syracuse?

    Yes. Cheapflights offers flight deals from Knoxville to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Syracuse?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $160). Flying from Knoxville to Syracuse in March is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
East Syracuse
Liverpool
Waterloo

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Knoxville to Syracuse

Discover the top 2 airlines that operate flights from Knoxville to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$238Average$338FlexibilityNo cancel feeOn-time71%
DeltaCheapest$242Average$322FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.