$169+ Cheap flights from Knoxville to Islip, NY (TYS - ISP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/28. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — ISP
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Islip with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Islip
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Best
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One-way
Cheapest flights from Knoxville to IslipExplore the most affordable flight options available from Knoxville to Islip. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Knoxville to Islip. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:20 am -
1 stop6h 10m
Thu 10/295:40 pm -
1 stop3h 55m
Deal found 9/9![Southwest logo]()
$287
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:20 am -
1 stop7h 25m
Wed 10/144:20 pm -
1 stop3h 50m
Deal found 9/9![Southwest logo]()
$332
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:51 pm -
1 stop27h 39m
Sun 10/186:25 pm -
1 stop16h 49m
Deal found 9/6![Multiple Airlines logo]()
$376
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/912:50 pm -
1 stop10h 25m
Mon 10/125:40 pm -
1 stop3h 55m
Deal found 9/7![Southwest logo]()
$442
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:00 pm -
1 stop8h 35m
Mon 9/284:05 pm -
1 stop3h 55m
Deal found 9/9![Southwest logo]()
$447
Best flights from Knoxville to IslipDiscover carefully curated flight deals from Knoxville to Islip that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Knoxville to Islip that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:50 pm -
2 stops9h 50m
Thu 10/293:10 pm -
1 stop6h 25m
Deal found 9/9![Southwest logo]()
$332
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:20 am -
1 stop7h 25m
Wed 10/149:40 am -
2 stops7h 00m
Deal found 9/9![Southwest logo]()
$358
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:00 pm -
1 stop8h 35m
Mon 9/286:10 am -
2 stops11h 00m
Deal found 9/9![Southwest logo]()
$452
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:00 pm -
2 stops9h 40m
Thu 10/223:10 pm -
1 stop6h 25m
Deal found 9/7![Southwest logo]()
$477
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:45 am -
1 stop5h 20m
Mon 11/305:35 am -
1 stop11h 25m
Deal found 9/6![Southwest logo]()
$546
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/912:50 pm -
1 stop10h 25m
Fri 10/165:40 pm -
1 stop3h 55m
Deal found 9/9![Southwest logo]()
$556
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/108:10 am -
2 stops12h 00m
Thu 10/155:40 pm -
1 stop3h 55m
Deal found 9/9![Southwest logo]()
$559
Last-minute flights from Knoxville to IslipDiscover last-minute flight deals from Knoxville to Islip. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Islip. Data last updated September 10, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:00 pm -
1 stop8h 35m
Mon 9/284:05 pm -
1 stop3h 55m
Deal found 9/9![Southwest logo]()
$447
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:20 am -
1 stop7h 25m
Wed 10/144:20 pm -
1 stop3h 50m
Deal found 9/9![Southwest logo]()
$332
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/912:50 pm -
1 stop10h 25m
Mon 10/125:40 pm -
1 stop3h 55m
Deal found 9/7![Southwest logo]()
$442
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:51 pm -
1 stop27h 39m
Sun 10/186:25 pm -
1 stop16h 49m
Deal found 9/6![Multiple Airlines logo]()
$376
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:20 am -
1 stop6h 10m
Thu 10/295:40 pm -
1 stop3h 55m
Deal found 9/9![Southwest logo]()
$287
One-way flights from Knoxville to IslipSearch for one-way flight options from Knoxville to Islip. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Knoxville to Islip. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2812:22 pm -
1 stop28h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$169
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:00 am -
2 stops7h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Southwest logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:18 pm -
3 stops47h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$314
Find flight deals from Knoxville to Islip
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Islip (ISP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $287 (Southwest) |
One-way from | $169 (Kiwi.com) |
Popular in | March |
Cheapest in | July |
Average price | $361 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Islip that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Knoxville to Islip that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleIslip
TYS Knoxville McGhee Tyson - ISP Islip Long Island
TYSISP
Knoxville McGhee Tyson
Mon 9/28
12:22 pm-4:58 pm
1 stop28h 36m
Islip Long Island
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$169
Quickest round-trip
KnoxvilleIslip
TYS Knoxville McGhee Tyson - ISP Islip Long Island
TYSISP
Knoxville McGhee Tyson
Wed 9/23
8:05 am-5:00 pm
1 stop8h 55m
Islip Long Island
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$229
KnoxvilleIslip
TYS Knoxville McGhee Tyson - ISP Islip Long Island
TYSISP
Knoxville McGhee Tyson
Thu 10/22
1:50 pm-11:40 pm
2 stops9h 50m
Islip Long Island
Thu 10/29
3:10 pm-9:35 pm
1 stop6h 25m
$332
KnoxvilleIslip
TYS Knoxville McGhee Tyson - ISP Islip Long Island
TYSISP
Knoxville McGhee Tyson
Wed 10/7
8:20 am-3:45 pm
1 stop7h 25m
Islip Long Island
Wed 10/14
9:40 am-4:40 pm
2 stops7h 00m
$358
KnoxvilleIslip
TYS Knoxville McGhee Tyson - ISP Islip Long Island
TYSISP
Knoxville McGhee Tyson
Thu 9/24
1:00 pm-9:35 pm
1 stop8h 35m
Islip Long Island
Mon 9/28
6:10 am-5:10 pm
2 stops11h 00m
$452
KnoxvilleIslip
TYS Knoxville McGhee Tyson - ISP Islip Long Island
TYSISP
Knoxville McGhee Tyson
Tue 10/20
1:00 pm-10:40 pm
2 stops9h 40m
Islip Long Island
Thu 10/22
3:10 pm-9:35 pm
1 stop6h 25m
$477
KnoxvilleIslip
TYS Knoxville McGhee Tyson - ISP Islip Long Island
TYSISP
Knoxville McGhee Tyson
Fri 11/20
11:45 am-5:05 pm
1 stop5h 20m
Islip Long Island
Mon 11/30
5:35 am-5:00 pm
1 stop11h 25m
$546
KnoxvilleIslip
TYS Knoxville McGhee Tyson - ISP Islip Long Island
TYSISP
Knoxville McGhee Tyson
Fri 10/9
12:50 pm-11:15 pm
1 stop10h 25m
Islip Long Island
Fri 10/16
5:40 pm-9:35 pm
1 stop3h 55m
$556
KnoxvilleIslip
TYS Knoxville McGhee Tyson - ISP Islip Long Island
TYSISP
Knoxville McGhee Tyson
Sat 10/10
8:10 am-8:10 pm
2 stops12h 00m
Islip Long Island
Thu 10/15
5:40 pm-9:35 pm
1 stop3h 55m
$559
Sorted by cheapest first
Compare providers for flights from Knoxville to Islip
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Islip in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Islip, New York flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Islip, New York flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Islip, New York flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Islip, New York flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Islip, New York flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Islip
Have a flexible travel schedule? Discover the best time to fly to Islip from Knoxville with our price prediction graph.
TYS-ISP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Islip
Get insights into the airlines that provide service to Islip. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Islip. Reviews last updated September 10, 2026.
Get a feel of what it's like to fly with Southwest from Knoxville to Islip by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Overall
8.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Comfort
8.0
Overall
8.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodSharilynn,May 2024
HOU - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Islip. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Islip?
Book flights to Islip if you plan to visit one of these locationsRiverhead
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Other flights to Islip
Explore flights to Islip departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
Knoxville and Islip flights
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Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Knoxville to Islip
Discover the top airline that operate flights from Knoxville to Islip. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$317 | Average$423 | FlexibilityNo cancel fee | On-time63% |