$153+ Cheap flights from Fort Myers to Knoxville (RSW - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — TYS
Oct 9 — Oct 161
Round-trip
1 adult, Economy
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Find cheap flights from Fort Myers to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Fort Myers to Knoxville
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Cheapest flights from Fort Myers to KnoxvilleExplore the most affordable flight options available from Fort Myers to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from Fort Myers to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:14 am -
1 stop4h 08m
Wed 10/76:06 pm -
1 stop5h 52m
Deal found 9/5![American Airlines logo]()
$305
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:11 pm -
1 stop5h 30m
Sat 11/75:19 pm -
1 stop4h 42m
Deal found 9/6![American Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:10 am -
1 stop5h 16m
Tue 12/15:40 am -
1 stop4h 09m
Deal found 9/6![Delta logo]()
$323
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:30 am -
1 stop4h 04m
Sun 10/115:40 am -
1 stop4h 10m
Deal found 9/8![Delta logo]()
$326
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:01 am -
1 stop7h 16m
Sun 12/139:33 am -
1 stop5h 02m
Deal found 9/7![American Airlines logo]()
$336
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:25 pm -
1 stop7h 10m
Wed 10/287:15 am -
1 stop6h 05m
Deal found 9/7![Southwest logo]()
$347
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:19 pm -
1 stop5h 36m
Thu 10/17:50 am -
1 stop6h 31m
Deal found 9/5![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:20 am -
1 stop5h 45m
Wed 10/78:20 am -
2 stops8h 45m
Deal found 9/5![Southwest logo]()
$361
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/185:30 am -
1 stop4h 04m
Sun 10/257:45 pm -
1 stop4h 36m
Deal found 9/6![Delta logo]()
$363
Best flights from Fort Myers to KnoxvilleDiscover carefully curated flight deals from Fort Myers to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from Fort Myers to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:10 am -
1 stop5h 16m
Tue 12/15:40 am -
1 stop4h 09m
Deal found 9/6![Delta logo]()
$323
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2511:10 am -
2 stops10h 30m
Sun 12/68:10 am -
1 stop10h 00m
Deal found 9/8![Southwest logo]()
$423
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:10 am -
1 stop5h 16m
Mon 11/3012:34 pm -
1 stop6h 20m
Deal found 9/6![Delta logo]()
$363
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:10 pm -
1 stop3h 30m
Mon 10/512:50 pm -
2 stops9h 20m
Deal found 9/5![Southwest logo]()
$441
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:30 pm -
1 stop5h 29m
Mon 10/196:23 pm -
1 stop5h 58m
Deal found 9/5![Delta logo]()
$447
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1912:25 pm -
1 stop5h 20m
Wed 9/237:00 am -
2 stops10h 00m
Deal found 9/4![Southwest logo]()
$452
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1811:45 am -
2 stops11h 00m
Sun 10/256:25 am -
1 stop6h 40m
Deal found 9/6![Southwest logo]()
$498
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:25 am -
1 stop9h 25m
Tue 11/2412:40 pm -
2 stops10h 40m
Deal found 9/4![Southwest logo]()
$512
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/287:20 am -
2 stops11h 20m
Fri 10/212:50 pm -
2 stops9h 15m
Deal found 9/8![Southwest logo]()
$564
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:00 pm -
1 stop6h 40m
Sun 11/87:25 pm -
2 stops13h 25m
Deal found 9/6![Southwest logo]()
$569
Last-minute flights from Fort Myers to KnoxvilleDiscover last-minute flight deals from Fort Myers to Knoxville. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from Fort Myers to Knoxville. Data last updated September 9, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:14 am -
1 stop4h 08m
Wed 10/76:06 pm -
1 stop5h 52m
Deal found 9/5![American Airlines logo]()
$305
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:19 pm -
1 stop5h 36m
Thu 10/17:50 am -
1 stop6h 31m
Deal found 9/5![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:20 am -
1 stop5h 45m
Wed 10/78:20 am -
2 stops8h 45m
Deal found 9/5![Southwest logo]()
$361
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:30 am -
1 stop4h 04m
Sun 10/115:40 am -
1 stop4h 10m
Deal found 9/8![Delta logo]()
$326
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/185:30 am -
1 stop4h 04m
Sun 10/257:45 pm -
1 stop4h 36m
Deal found 9/6![Delta logo]()
$363
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:25 pm -
1 stop7h 10m
Wed 10/287:15 am -
1 stop6h 05m
Deal found 9/7![Southwest logo]()
$347
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:25 pm -
1 stop7h 10m
Sun 11/112:50 pm -
1 stop9h 10m
Deal found 9/4![Southwest logo]()
$375
One-way flights from Fort Myers to KnoxvilleSearch for one-way flight options from Fort Myers to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
Search for one-way flight options from Fort Myers to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/143:10 pm -
1 stop5h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Southwest logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/169:04 pm -
3 stops35h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$206
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:01 am -
1 stop7h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![American Airlines logo]()
$234
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2311:10 am -
2 stops10h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Southwest logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:00 am -
3 stops35h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$248
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:30 pm -
1 stop5h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Delta logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/912:45 pm -
1 stop10h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$280
This KAYAK deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:35 pm -
1 stop4h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Delta logo]()
$318
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:15 am -
2 stops8h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Southwest logo]()
$320
Find flight deals from Fort Myers to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $305 (American Airlines) |
One-way from | $153 (Southwest) |
Popular in | January |
Cheapest in | August |
Average price | $411 |
Cheapflights Fare Finder
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Fort MyersKnoxville
RSW Fort Myers SW Florida Intl - TYS Knoxville McGhee Tyson
RSWTYS
Fort Myers SW Florida Intl
Wed 10/14
7:45 am-4:40 pm
2 stops8h 55m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$189
Fort MyersKnoxville
RSW Fort Myers SW Florida Intl - TYS Knoxville McGhee Tyson
RSWTYS
Fort Myers SW Florida Intl
Fri 10/16
9:04 pm-8:08 am
2 stops35h 04m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$224
Fort MyersKnoxville
RSW Fort Myers SW Florida Intl - TYS Knoxville McGhee Tyson
RSWTYS
Fort Myers SW Florida Intl
Wed 12/23
4:25 pm-10:35 pm
1 stop6h 10m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$234
Fort MyersKnoxville
RSW Fort Myers SW Florida Intl - TYS Knoxville McGhee Tyson
RSWTYS
Fort Myers SW Florida Intl
Wed 10/14
7:00 am-6:21 pm
3 stops35h 21m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$248
Fort MyersKnoxville
RSW Fort Myers SW Florida Intl - TYS Knoxville McGhee Tyson
RSWTYS
Fort Myers SW Florida Intl
Fri 10/9
12:45 pm-11:35 pm
1 stop10h 50m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$280
Fort MyersKnoxville
RSW Fort Myers SW Florida Intl - TYS Knoxville McGhee Tyson
RSWTYS
Fort Myers SW Florida Intl
Mon 9/14
3:35 pm-8:15 pm
1 stop4h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$318
Fort MyersKnoxville
RSW Fort Myers SW Florida Intl - TYS Knoxville McGhee Tyson
RSWTYS
Fort Myers SW Florida Intl
Fri 11/27
8:15 am-4:50 pm
2 stops8h 35m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$320
Fort MyersKnoxville
RSW Fort Myers SW Florida Intl - TYS Knoxville McGhee Tyson
RSWTYS
Fort Myers SW Florida Intl
Thu 11/26
8:10 am-1:26 pm
1 stop5h 16m
Knoxville McGhee Tyson
Tue 12/1
5:40 am-9:49 am
1 stop4h 09m
$323
Fort MyersKnoxville
RSW Fort Myers SW Florida Intl - TYS Knoxville McGhee Tyson
RSWTYS
Fort Myers SW Florida Intl
Mon 9/14
11:14 am-11:07 pm
2 stops11h 53m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$342
Fort MyersKnoxville
RSW Fort Myers SW Florida Intl - TYS Knoxville McGhee Tyson
RSWTYS
Fort Myers SW Florida Intl
Thu 11/26
8:10 am-1:26 pm
1 stop5h 16m
Knoxville McGhee Tyson
Mon 11/30
12:34 pm-6:54 pm
1 stop6h 20m
$363
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Fort Myers to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Fort Myers-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Fort Myers-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Fort Myers-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Fort Myers-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Fort Myers to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Fort Myers with our price prediction graph.
RSW-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Fort Myers to Knoxville
What is the cheapest month to book a flight from Fort Myers to Knoxville?
Currently, August is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $268). Flying from Fort Myers to Knoxville in January is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Fort Myers to Knoxville?
Airfare is below average for this route at the moment.
Fort Myers to Knoxville flights typically cost between $319 and $660 in November.The cheapest round-trip price found within the last 5 days was $294 on American Airlines (Nov 1-Nov 7).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 9, 2026.
See what other customers who have flown with Delta and American Airlines from Fort Myers to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Food
7.2
Comfort
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Food
7.2
Comfort
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Food
7.2
Comfort
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Fort Myers to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 9, 2026.
Fort Myers and Knoxville flights
Browse other Fort Myers and Knoxville flight options. Last updated on September 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Fort Myers to Knoxville
Discover the top 2 airlines that operate flights from Fort Myers to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$259 | Average$477 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$294 | Average$389 | FlexibilityNo cancel fee | On-timeN/A |