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Knoxville

$138+ Cheap flights from Fort Myers to Knoxville (RSW - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/10. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — TYS
Jun 4 — Jun 111
Thu 6/4
Thu 6/11
1 adult, Economy
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Cheap flight deals from Fort Myers to Knoxville

Cheapest flights from Fort Myers to Knoxville
Explore the most affordable flight options available from Fort Myers to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.

This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
RSW
-
TYS
1 stop4h 36m
American Airlines
Wed 5/275:00 am
TYS
-
RSW
1 stop4h 07m
American Airlines
Deal found 5/2$278
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/98:03 am
RSW
-
TYS
1 stop6h 46m
Delta
Wed 6/175:40 am
TYS
-
RSW
1 stop4h 08m
Delta
Deal found 5/4$281
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
RSW
-
TYS
1 stop4h 36m
American Airlines
Sat 6/66:07 pm
TYS
-
RSW
1 stop4h 51m
American Airlines
Deal found 4/30$291
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:34 pm
RSW
-
TYS
1 stop4h 24m
American Airlines
Sun 9/65:00 am
TYS
-
RSW
1 stop4h 11m
American Airlines
Deal found 5/4$292
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:37 am
RSW
-
TYS
1 stop5h 32m
Delta
Wed 6/175:40 am
TYS
-
RSW
1 stop4h 08m
Delta
Deal found 5/4$294
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
RSW
-
TYS
1 stop4h 36m
American Airlines
Sat 6/136:07 pm
TYS
-
RSW
1 stop4h 51m
American Airlines
Deal found 5/1$295
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:45 am
RSW
-
TYS
1 stop6h 25m
Delta
Tue 6/28:35 am
TYS
-
RSW
1 stop3h 44m
Delta
Deal found 5/4$304
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:16 am
RSW
-
TYS
1 stop6h 08m
American Airlines
Mon 6/86:07 pm
TYS
-
RSW
1 stop4h 51m
American Airlines
Deal found 5/2$305
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:37 am
RSW
-
TYS
1 stop4h 01m
Delta
Thu 6/115:40 am
TYS
-
RSW
1 stop4h 08m
Delta
Deal found 5/4$306
This Trip.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:50 am
RSW
-
TYS
1 stop4h 16m
Delta
Sat 11/1410:05 am
TYS
-
RSW
1 stop6h 28m
Delta
Deal found 5/3$311

Find flight deals from Fort Myers to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$278
(American Airlines)

One-way from

$138
(Southwest)

Popular in

January

Cheapest in

September

Average price

$328
Provider with most accurate pricing for Fort Myers SW Florida Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Knoxville McGhee Tyson flights.
Search Deals
From Fort Myers SW Florida Intl to Knoxville McGhee Tyson
Search Deals
One-way flight from Fort Myers SW Florida Intl to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($95 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 6/9

5:37 am-9:38 am

1 stop4h 01m

Knoxville McGhee Tyson

Thu 6/11

5:40 am-9:48 am

1 stop4h 08m

$306

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 6/11

5:37 am-9:38 am

1 stop4h 01m

Knoxville McGhee Tyson

Mon 6/15

8:35 am-2:45 pm

1 stop6h 10m

$331

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 7/24

6:45 am-1:16 pm

1 stop6h 31m

Knoxville McGhee Tyson

Fri 7/24

7:43 pm-1:00 am

1 stop5h 17m

$331

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 5/23

5:46 pm-12:01 am

1 stop6h 15m

Knoxville McGhee Tyson

Wed 5/27

5:40 am-9:47 am

1 stop4h 07m

$364

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 5/30

10:30 am-6:30 pm

1 stop8h 00m

Knoxville McGhee Tyson

Sat 6/6

8:00 am-9:55 pm

2 stops13h 55m

$385

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 5/19

11:55 am-7:40 pm

2 stops7h 45m

Knoxville McGhee Tyson

Sat 5/23

7:45 am-6:45 pm

1 stop11h 00m

$440

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 5/16

6:25 am-1:20 pm

2 stops6h 55m

Knoxville McGhee Tyson

Wed 5/20

12:50 pm-9:35 pm

1 stop8h 45m

$440

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Mon 6/1

12:55 pm-9:15 pm

2 stops8h 20m

Knoxville McGhee Tyson

Mon 6/8

7:30 am-6:40 pm

2 stops11h 10m

$477

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 6/5

11:40 am-9:10 pm

2 stops9h 30m

Knoxville McGhee Tyson

Mon 6/8

7:30 am-6:40 pm

2 stops11h 10m

$507
Cheapest one-way

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Wed 6/10

6:10 am-5:00 pm

1 stop10h 50m

$138

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/3

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Fort Myers to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Knoxville in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Fort Myers-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Fort Myers-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Fort Myers-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Fort Myers-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Knoxville

What is the cheapest month to book a flight from Fort Myers to Knoxville?

Currently, September is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $319). Flying from Fort Myers to Knoxville in January is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Fort Myers to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 5, 2026.
See what other customers who have flown with Delta and American Airlines from Fort Myers to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,459 reviews

Entertainment

7.8

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,459 reviews
Delta
7.9
Good
8,459 reviews

Entertainment

7.8

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.1
Good
11,668 reviews
Delta
7.9
Good
8,459 reviews

Entertainment

7.8

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Fort Myers to Knoxville?

    There are many flights that can get you from Fort Myers to Knoxville in 4h 01m. Fly via Delta or Southwest to get the fastest option. Fort Myers and Knoxville are separated by a distance of 653 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Fort Myers to Knoxville round-trip?

    American Airlines, at $248, was found to be the cheapest airline from Fort Myers to Knoxville. An alternate airline flying to your destination would be Delta. American Airlines is priced at 40% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Fort Myers to Knoxville that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Knoxville.

  • Can I find deals for business class flights from Fort Myers to Knoxville?

    Yes. Cheapflights offers flight deals from Fort Myers to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Knoxville?

    Currently, September is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $319). Flying from Fort Myers to Knoxville in January is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

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Top 2 airlines flying from Fort Myers to Knoxville

Discover the top 2 airlines that operate flights from Fort Myers to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$411FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$373FlexibilityNo cancel feeOn-timeN/A

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