HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$126+ Cheap flights from Fort Myers to Knoxville (RSW - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — TYS
Aug 24 — Aug 311
Mon 8/24
Mon 8/31
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Fort Myers to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Fort Myers to Knoxville

Cheapest flights from Fort Myers to Knoxville
Explore the most affordable flight options available from Fort Myers to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 25, 2026.

This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:02 pm
RSW
-
TYS
1 stop5h 57m
American Airlines
Sun 9/67:00 am
TYS
-
RSW
1 stop6h 10m
American Airlines
Deal found 7/21$251
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/33:02 pm
RSW
-
TYS
1 stop5h 57m
American Airlines
Tue 9/85:15 am
TYS
-
RSW
1 stop4h 59m
American Airlines
Deal found 7/24$259
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:40 am
RSW
-
TYS
2 stops11h 10m
Southwest
Tue 10/61:00 pm
TYS
-
RSW
1 stop9h 00m
Southwest
Deal found 7/23$262
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:00 am
RSW
-
TYS
1 stop3h 44m
Delta
Tue 10/65:45 am
TYS
-
RSW
1 stop4h 04m
Delta
Deal found 7/23$269
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:10 am
RSW
-
TYS
1 stop4h 41m
Delta
Mon 9/144:40 pm
TYS
-
RSW
1 stop4h 54m
Delta
Deal found 7/23$277
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:15 am
RSW
-
TYS
1 stop5h 55m
Southwest
Mon 10/2612:50 pm
TYS
-
RSW
2 stops9h 15m
Southwest
Deal found 7/23$280
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:50 pm
RSW
-
TYS
1 stop4h 09m
Delta
Thu 10/155:45 am
TYS
-
RSW
1 stop4h 04m
Delta
Deal found 7/23$283
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/264:05 pm
RSW
-
TYS
1 stop4h 03m
Delta
Fri 10/305:45 am
TYS
-
RSW
1 stop4h 04m
Delta
Deal found 7/23$288
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:25 pm
RSW
-
TYS
1 stop7h 05m
Southwest
Tue 10/278:20 am
TYS
-
RSW
1 stop6h 10m
Southwest
Deal found 7/22$290

Find flight deals from Fort Myers to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$251
(American Airlines)

One-way from

$126
(Southwest)

Popular in

January

Cheapest in

September

Average price

$376
Provider with most accurate pricing for Fort Myers SW Florida Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Knoxville McGhee Tyson flights.
Search Deals
From Fort Myers SW Florida Intl to Knoxville McGhee Tyson
Search Deals
One-way flight from Fort Myers SW Florida Intl to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($91 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($27 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sun 11/1

8:15 am-12:10 pm

1 stop3h 55m

Knoxville McGhee Tyson

Wed 11/4

1:00 pm-9:05 pm

2 stops8h 05m

$290

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 9/11

7:00 am-10:44 am

1 stop3h 44m

Knoxville McGhee Tyson

Mon 9/14

7:25 pm-12:35 am

1 stop5h 10m

$314
Quickest round-trip

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 10/16

1:12 pm-5:36 pm

1 stop4h 24m

Knoxville McGhee Tyson

Mon 10/19

7:25 pm-11:09 pm

1 stop3h 44m

$316

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 11/7

10:45 am-7:45 pm

2 stops9h 00m

Knoxville McGhee Tyson

Wed 11/11

1:00 pm-9:05 pm

2 stops8h 05m

$318

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Mon 11/9

3:06 pm-6:38 pm

1 stop3h 32m

Knoxville McGhee Tyson

Fri 11/13

5:30 am-12:01 pm

1 stop6h 31m

$322

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 10/23

2:25 pm-10:40 pm

2 stops8h 15m

Knoxville McGhee Tyson

Tue 10/27

8:20 am-5:05 pm

2 stops8h 45m

$329

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 10/29

2:25 pm-9:30 pm

1 stop7h 05m

Knoxville McGhee Tyson

Sun 11/1

12:50 pm-9:50 pm

2 stops9h 00m

$334

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 8/4

2:35 pm-6:55 pm

1 stop4h 20m

Knoxville McGhee Tyson

Thu 8/6

7:10 am-3:05 pm

1 stop7h 55m

$452
Cheapest one-way

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 9/1

12:20 pm-7:50 pm

1 stop7h 30m

$126

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Wed 9/2

12:20 pm-7:50 pm

1 stop7h 30m

$126

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/21

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Compare providers for flights from Fort Myers to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Knoxville in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Fort Myers-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Fort Myers-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Fort Myers-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Fort Myers-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Knoxville

What is the cheapest month to book a flight from Fort Myers to Knoxville?

Currently, September is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $328). Flying from Fort Myers to Knoxville in January is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Fort Myers to Knoxville?

Airfare is below average for this route at the moment.

Fort Myers to Knoxville flights typically cost between $338 and $474 in September.
The cheapest round-trip price found within the last 5 days was $251 on American Airlines (Sep 1-Sep 6).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 25, 2026.
See what other customers who have flown with Delta and American Airlines from Fort Myers to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,486 reviews

Overall

7.8

Boarding

8.1

Crew

8.5

Food

7.2

Comfort

7.8

Entertainment

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.8
Good
8,486 reviews
Delta
7.8
Good
8,486 reviews

Overall

7.8

Boarding

8.1

Crew

8.5

Food

7.2

Comfort

7.8

Entertainment

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.1
Good
11,848 reviews
Delta
7.8
Good
8,486 reviews

Overall

7.8

Boarding

8.1

Crew

8.5

Food

7.2

Comfort

7.8

Entertainment

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Fort Myers to Knoxville?

    There are many flights that can get you from Fort Myers to Knoxville in 3h 44m. Fly via Southwest or Delta to get the fastest option. Fort Myers and Knoxville are separated by a distance of 653 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Fort Myers to Knoxville round-trip?

    American Airlines, at $258, was found to be the cheapest airline from Fort Myers to Knoxville. An alternate airline flying to your destination would be Delta. American Airlines is priced at 39% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Fort Myers to Knoxville that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Knoxville.

  • Can I find deals for business class flights from Fort Myers to Knoxville?

    Yes. Cheapflights offers flight deals from Fort Myers to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Knoxville?

    Currently, September is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $328). Flying from Fort Myers to Knoxville in January is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Fort Myers to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to Nashville flights
Orlando to Nashville flights
Tampa to Nashville flights
Miami to Nashville flights
West Palm Beach to Nashville flights
Jacksonville to Nashville flights
Orlando to Memphis flights
Orlando to Chattanooga flights
Orlando Sanford Intl to Knoxville flights
Fort Myers to Nashville flights
Fort Lauderdale to Knoxville flights
Orlando to Knoxville flights
Sarasota to Nashville flights
Tampa to Knoxville flights
Pensacola to Nashville flights
Panama City to Nashville flights
Miami to Knoxville flights
St Petersburg to Knoxville flights
Tampa to Chattanooga flights
Fort Lauderdale to Memphis flights
Jacksonville to Memphis flights
West Palm Beach to Knoxville flights
Tampa to Memphis flights
Sarasota to Knoxville flights
Miami to Memphis flights
Miami to Chattanooga flights
West Palm Beach to Memphis flights
Jacksonville to Knoxville flights
Fort Lauderdale to Chattanooga flights
Valparaiso to Nashville flights
Sarasota to Chattanooga flights
Fort Myers to Chattanooga flights
Jacksonville to Chattanooga flights
Punta Gorda to Nashville flights
Gainesville to Memphis flights
Pensacola to Knoxville flights
Tallahassee to Nashville flights
Melbourne to Nashville flights
Fort Myers to Memphis flights
Daytona Beach to Nashville flights
Sarasota to Memphis flights
Tampa to Blountville flights
Orlando to Blountville flights
West Palm Beach to Chattanooga flights
Daytona Beach to Memphis flights
Tallahassee to Knoxville flights
Pensacola to Chattanooga flights

Top 2 airlines flying from Fort Myers to Knoxville

Discover the top 2 airlines that operate flights from Fort Myers to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$458FlexibilityNo cancel feeOn-time71%
DeltaCheapest$280Average$373FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights