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$125+ Cheap flights from Fort Myers to Knoxville (RSW - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — TYS
May 23 — May 301
Sat 5/23
Sat 5/30
1 adult, Economy
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Cheap flight deals from Fort Myers to Knoxville

Cheapest flights from Fort Myers to Knoxville
Explore the most affordable flight options available from Fort Myers to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.

This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:46 pm
RSW
-
TYS
1 stop6h 15m
Delta
Wed 5/273:30 pm
TYS
-
RSW
1 stop5h 14m
Delta
Deal found 4/21$230
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/198:00 am
RSW
-
TYS
1 stop6h 33m
Delta
Wed 5/205:59 pm
TYS
-
RSW
1 stop6h 28m
Delta
Deal found 4/20$248
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
RSW
-
TYS
1 stop6h 26m
American Airlines
Wed 5/275:00 am
TYS
-
RSW
1 stop4h 07m
American Airlines
Deal found 4/20$255
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:06 pm
RSW
-
TYS
1 stop6h 40m
Delta
Mon 8/247:20 pm
TYS
-
RSW
1 stop5h 16m
Delta
Deal found 4/21$267
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:20 am
RSW
-
TYS
1 stop9h 50m
Southwest
Wed 9/28:00 am
TYS
-
RSW
2 stops11h 50m
Southwest
Deal found 4/20$268
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:35 am
RSW
-
TYS
1 stop5h 34m
Delta
Tue 5/197:33 pm
TYS
-
RSW
1 stop4h 54m
Delta
Deal found 4/20$273
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:00 pm
RSW
-
TYS
1 stop5h 17m
Delta
Sun 9/65:30 am
TYS
-
RSW
1 stop4h 26m
Delta
Deal found 4/20$277
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:35 am
RSW
-
TYS
1 stop4h 22m
Delta
Sat 6/136:00 am
TYS
-
RSW
1 stop3h 31m
Delta
Deal found 4/22$280
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:45 am
RSW
-
TYS
2 stops10h 25m
Southwest
Wed 5/2012:50 pm
TYS
-
RSW
1 stop8h 45m
Southwest
Deal found 4/20$290
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:55 am
RSW
-
TYS
2 stops11h 00m
Southwest
Tue 8/258:00 am
TYS
-
RSW
2 stops11h 50m
Southwest
Deal found 4/21$291
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/158:45 am
RSW
-
TYS
2 stops11h 05m
Southwest
Fri 9/1812:30 pm
TYS
-
RSW
1 stop9h 30m
Southwest
Deal found 4/20$297

Find flight deals from Fort Myers to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$230
(Delta)

One-way from

$125
(Delta)

Popular in

January

Cheapest in

September

Average price

$375
Provider with most accurate pricing for Fort Myers SW Florida Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Knoxville McGhee Tyson flights.
Search Deals
From Fort Myers SW Florida Intl to Knoxville McGhee Tyson
Search Deals
One-way flight from Fort Myers SW Florida Intl to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($95 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 5/30

5:35 am-9:57 am

1 stop4h 22m

Knoxville McGhee Tyson

Sat 6/13

6:00 am-9:31 am

1 stop3h 31m

$280

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 5/15

6:45 am-11:09 am

1 stop4h 24m

Knoxville McGhee Tyson

Tue 5/19

5:40 am-9:47 am

1 stop4h 07m

$325

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 5/9

6:25 am-1:20 pm

2 stops6h 55m

Knoxville McGhee Tyson

Tue 5/12

12:50 pm-9:35 pm

1 stop8h 45m

$354

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 7/21

5:35 am-11:05 am

1 stop5h 30m

Knoxville McGhee Tyson

Thu 7/23

3:54 pm-9:10 pm

1 stop5h 16m

$362

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 5/8

12:55 pm-9:15 pm

2 stops8h 20m

Knoxville McGhee Tyson

Tue 5/12

12:50 pm-9:35 pm

1 stop8h 45m

$388

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 6/12

6:34 pm-11:54 pm

1 stop5h 20m

Knoxville McGhee Tyson

Sun 6/14

5:40 am-9:31 am

1 stop3h 51m

$393

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sun 9/20

1:00 pm-6:17 pm

1 stop5h 17m

Knoxville McGhee Tyson

Thu 9/24

5:30 am-11:57 am

1 stop6h 27m

$413

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 6/4

11:40 am-10:30 pm

2 stops10h 50m

Knoxville McGhee Tyson

Sun 6/7

7:00 pm-10:55 pm

1 stop3h 55m

$422

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sun 5/3

8:25 am-7:00 pm

2 stops10h 35m

Knoxville McGhee Tyson

Tue 5/12

12:50 pm-9:35 pm

1 stop8h 45m

$430

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 5/16

10:30 am-6:30 pm

1 stop8h 00m

Knoxville McGhee Tyson

Sun 5/24

7:30 am-5:15 pm

2 stops9h 45m

$434

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Compare providers for flights from Fort Myers to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Fort Myers to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Fort Myers-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Fort Myers-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Fort Myers-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Fort Myers-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to Knoxville

What is the cheapest month to book a flight from Fort Myers to Knoxville?

Currently, September is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $319). Flying from Fort Myers to Knoxville in January is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Fort Myers to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 23, 2026.
See what other customers who have flown with Delta and American Airlines from Fort Myers to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,438 reviews

Boarding

8.1

Food

7.2

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,438 reviews
Delta
7.9
Good
8,438 reviews

Boarding

8.1

Food

7.2

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.1
Good
11,659 reviews
Delta
7.9
Good
8,438 reviews

Boarding

8.1

Food

7.2

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Fort Myers to Knoxville?

    There are many flights that can get you from Fort Myers to Knoxville in 5h 30m. Fly via Southwest or Delta to get the fastest option. Fort Myers and Knoxville are separated by a distance of 653 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Fort Myers to Knoxville round-trip?

    American Airlines, at $248, was found to be the cheapest airline from Fort Myers to Knoxville. An alternate airline flying to your destination would be Delta. American Airlines is priced at 40% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Fort Myers to Knoxville that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Knoxville.

  • Can I find deals for business class flights from Fort Myers to Knoxville?

    Yes. Cheapflights offers flight deals from Fort Myers to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Fort Myers to Knoxville?

    Currently, September is the cheapest month in which you can book a flight from Fort Myers to Knoxville (average of $319). Flying from Fort Myers to Knoxville in January is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Top 2 airlines flying from Fort Myers to Knoxville

Discover the top 2 airlines that operate flights from Fort Myers to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$438FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$373FlexibilityNo cancel feeOn-timeN/A

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