$113+ Cheap flights from Knoxville to Fort Myers (TYS - RSW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — RSW
Nov 8 — Nov 151
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Fort Myers with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Fort Myers
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Cheapest flights from Knoxville to Fort MyersExplore the most affordable flight options available from Knoxville to Fort Myers. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 9, 2026.
Explore the most affordable flight options available from Knoxville to Fort Myers. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 9, 2026.
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:01 am -
1 stop4h 16m
Sat 11/146:24 pm -
1 stop4h 24m
Deal found 10/6![American Airlines logo]()
$217
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:01 pm -
1 stop5h 36m
Wed 12/97:00 am -
1 stop6h 51m
Deal found 10/7![Delta logo]()
$225
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:50 pm -
1 stop9h 15m
Thu 11/127:25 am -
1 stop9h 25m
Deal found 10/8![Southwest logo]()
$228
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:55 am -
2 stops11h 55m
Sat 11/147:05 am -
1 stop8h 05m
Deal found 10/6![Southwest logo]()
$233
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:45 pm -
1 stop4h 36m
Fri 10/305:30 am -
1 stop5h 24m
Deal found 10/8![Delta logo]()
$300
This American Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:50 am -
1 stop4h 07m
Sat 11/212:32 pm -
1 stop7h 09m
Deal found 10/5![American Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:50 pm -
2 stops9h 45m
Mon 12/147:30 am -
1 stop4h 50m
Deal found 10/5![Southwest logo]()
$325
Best flights from Knoxville to Fort MyersDiscover carefully curated flight deals from Knoxville to Fort Myers that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 9, 2026.
Discover carefully curated flight deals from Knoxville to Fort Myers that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 9, 2026.
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:01 pm -
1 stop5h 36m
Wed 12/97:00 am -
1 stop6h 51m
Deal found 10/5![Delta logo]()
$225
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:50 pm -
1 stop9h 15m
Thu 11/127:25 am -
1 stop9h 25m
Deal found 10/8![Southwest logo]()
$228
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/91:15 pm -
1 stop8h 45m
Tue 2/168:15 am -
1 stop4h 05m
Deal found 10/7![Southwest logo]()
$317
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:23 pm -
1 stop4h 47m
Fri 10/306:30 pm -
1 stop3h 52m
Deal found 10/6![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/77:07 am -
1 stop6h 46m
Sun 1/105:35 am -
1 stop5h 31m
Deal found 10/5![Delta logo]()
$343
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:45 pm -
1 stop4h 30m
Sat 12/510:55 am -
2 stops8h 50m
Deal found 10/4![Southwest logo]()
$469
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:20 am -
2 stops8h 45m
Sat 10/247:05 am -
1 stop4h 55m
Deal found 10/6![Southwest logo]()
$472
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:11 pm -
1 stop5h 25m
Mon 10/267:00 am -
1 stop6h 40m
Deal found 10/8![Delta logo]()
$493
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:50 pm -
2 stops9h 05m
Fri 11/203:00 pm -
1 stop6h 45m
Deal found 10/4![Southwest logo]()
$486
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:15 am -
2 stops9h 45m
Mon 10/266:25 pm -
1 stop4h 20m
Deal found 10/8![Southwest logo]()
$509
Last-minute flights from Knoxville to Fort MyersDiscover last-minute flight deals from Knoxville to Fort Myers. Data last updated October 9, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Fort Myers. Data last updated October 9, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:45 pm -
1 stop4h 36m
Fri 10/305:30 am -
1 stop5h 24m
Deal found 10/8![Delta logo]()
$300
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:50 pm -
1 stop9h 15m
Thu 11/127:25 am -
1 stop9h 25m
Deal found 10/8![Southwest logo]()
$228
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:07 pm -
1 stop4h 55m
Wed 11/114:47 pm -
1 stop3h 56m
Deal found 10/4![American Airlines logo]()
$336
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:50 pm -
2 stops9h 05m
Wed 11/117:30 am -
1 stop4h 50m
Deal found 10/4![Southwest logo]()
$353
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:01 am -
1 stop4h 16m
Sat 11/146:24 pm -
1 stop4h 24m
Deal found 10/6![American Airlines logo]()
$217
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:55 am -
2 stops11h 55m
Sat 11/147:05 am -
1 stop8h 05m
Deal found 10/6![Southwest logo]()
$233
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:55 am -
2 stops11h 55m
Sat 11/147:05 am -
2 stops10h 40m
Deal found 10/6![Southwest logo]()
$358
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:50 pm -
1 stop9h 15m
Sat 11/147:05 am -
2 stops10h 40m
Deal found 10/4![Southwest logo]()
$345
This American Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:50 am -
1 stop4h 07m
Sat 11/212:32 pm -
1 stop7h 09m
Deal found 10/5![American Airlines logo]()
$304
One-way flights from Knoxville to Fort MyersSearch for one-way flight options from Knoxville to Fort Myers. Find affordable one-way fares based on user searches. Data last updated October 9, 2026.
Search for one-way flight options from Knoxville to Fort Myers. Find affordable one-way fares based on user searches. Data last updated October 9, 2026.
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:10 pm -
1 stop6h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Delta logo]()
$113
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/57:55 am -
2 stops14h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Southwest logo]()
$120
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/238:01 pm -
1 stop4h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/4![American Airlines logo]()
$165
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/238:00 am -
2 stops11h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/4![Southwest logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/119:10 am -
3 stops39h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$229
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:49 pm -
1 stop7h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![American Airlines logo]()
$234
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:20 am -
2 stops8h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Southwest logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/58:06 pm -
3 stops42h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$256
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1312:00 pm -
1 stop3h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Delta logo]()
$260
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:15 am -
1 stop6h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Southwest logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:14 pm -
3 stops32h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$284
Find flight deals from Knoxville to Fort Myers
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Fort Myers (RSW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $217 (American Airlines) |
One-way from | $113 (Delta) |
Popular in | September |
Cheapest in | February |
Average price | $437 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 9, 2026.
Use the filters below to find and compare flights from Knoxville to Fort Myers that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleFort Myers
TYS Knoxville McGhee Tyson - RSW Fort Myers SW Florida Intl
TYSRSW
Knoxville McGhee Tyson
Tue 1/5
6:00 am-9:59 am
1 stop3h 59m
Fort Myers SW Florida Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$113
KnoxvilleFort Myers
TYS Knoxville McGhee Tyson - RSW Fort Myers SW Florida Intl
TYSRSW
Knoxville McGhee Tyson
Tue 2/23
8:01 pm-12:31 am
1 stop4h 30m
Fort Myers SW Florida Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$165
KnoxvilleFort Myers
TYS Knoxville McGhee Tyson - RSW Fort Myers SW Florida Intl
TYSRSW
Knoxville McGhee Tyson
Tue 2/23
8:00 am-7:45 pm
2 stops11h 45m
Fort Myers SW Florida Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$195
KnoxvilleFort Myers
TYS Knoxville McGhee Tyson - RSW Fort Myers SW Florida Intl
TYSRSW
Knoxville McGhee Tyson
Tue 12/1
4:01 pm-9:37 pm
1 stop5h 36m
Fort Myers SW Florida Intl
Wed 12/9
7:00 am-1:51 pm
1 stop6h 51m
$225
KnoxvilleFort Myers
TYS Knoxville McGhee Tyson - RSW Fort Myers SW Florida Intl
TYSRSW
Knoxville McGhee Tyson
Thu 11/5
12:50 pm-10:05 pm
1 stop9h 15m
Fort Myers SW Florida Intl
Thu 11/12
7:25 am-4:50 pm
1 stop9h 25m
$228
KnoxvilleFort Myers
TYS Knoxville McGhee Tyson - RSW Fort Myers SW Florida Intl
TYSRSW
Knoxville McGhee Tyson
Sat 2/13
6:35 am-9:25 pm
2 stops14h 50m
Fort Myers SW Florida Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$239
KnoxvilleFort Myers
TYS Knoxville McGhee Tyson - RSW Fort Myers SW Florida Intl
TYSRSW
Knoxville McGhee Tyson
Wed 11/11
7:55 am-7:50 pm
2 stops11h 55m
Fort Myers SW Florida Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$239
KnoxvilleFort Myers
TYS Knoxville McGhee Tyson - RSW Fort Myers SW Florida Intl
TYSRSW
Knoxville McGhee Tyson
Wed 10/21
8:20 am-5:05 pm
2 stops8h 45m
Fort Myers SW Florida Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$239
KnoxvilleFort Myers
TYS Knoxville McGhee Tyson - RSW Fort Myers SW Florida Intl
TYSRSW
Knoxville McGhee Tyson
Wed 10/14
8:20 am-5:05 pm
2 stops8h 45m
Fort Myers SW Florida Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$276
KnoxvilleFort Myers
TYS Knoxville McGhee Tyson - RSW Fort Myers SW Florida Intl
TYSRSW
Knoxville McGhee Tyson
Wed 10/21
4:14 pm-12:21 am
3 stops32h 07m
Fort Myers SW Florida Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$284
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Fort Myers
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Fort Myers in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Fort Myers flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Fort Myers flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Fort Myers flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Fort Myers flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Fort Myers flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Fort Myers
Have a flexible travel schedule? Discover the best time to fly to Fort Myers from Knoxville with our price prediction graph.
TYS-RSW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Fort Myers
Reviews of airlines servicing Fort Myers
Get insights into the airlines that provide service to Fort Myers. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Fort Myers. Reviews last updated October 9, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Fort Myers to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Food
7.2
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Food
7.2
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Fort Myers. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Fort Myers?
Book flights to Fort Myers if you plan to visit one of these locationsNorth Fort Myers
Estero
Lehigh Acres
Sanibel
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Knoxville and Fort Myers flights
Browse other Knoxville and Fort Myers flight options. Last updated on October 9, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on October 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Fort Myers
Discover the top 2 airlines that operate flights from Knoxville to Fort Myers. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$368 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$267 | Average$480 | FlexibilityNo cancel fee | On-timeN/A |