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$184+ Cheap flights from Panama City, FL to Knoxville (ECP - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/10. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — TYS
Jul 14 — Jul 211
Mon 7/14
Mon 7/21
1 adult, Economy
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Cheap flight deals from Panama City to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 9, 2025.

Round-trip from

$283
(Delta)

One-way from

$184
(Delta)

Popular in

August

Cheapest in

September

Average price

$508
From Panama City NW Florida Beaches to Knoxville McGhee Tyson
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One-way flight from Panama City NW Florida Beaches to Knoxville McGhee Tyson
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Panama City to Knoxville

Cheapest flights from Panama City to Knoxville
Explore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 9, 2025.

This Delta deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/306:00 amECP - TYS
1 stop3h 27mDelta
Sun 8/319:40 amTYS - ECP
1 stop4h 28mDelta
Deal found 7/7$283
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/305:30 amECP - TYS
1 stop4h 00mAmerican Airlines
Sun 8/3111:15 amTYS - ECP
1 stop3h 48mAmerican Airlines
Deal found 7/8$323
This United Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/281:44 pmECP - TYS
2 stops24h 06mUnited Airlines
Mon 9/17:25 pmTYS - ECP
2 stops18h 38mUnited Airlines
Deal found 7/7$687

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 9, 2025.
Use the filters below to find and compare flights from Panama City to Knoxville that are best for you.

Fly from

Panama City

Fly to

Knoxville

Route

Depart

Return

Price

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 8/30

6:00 am-10:27 am

1 stop3h 27m

Knoxville McGhee Tyson

Sun 8/31

9:40 am-1:08 pm

1 stop4h 28m

$283

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 8/30

5:30 am-10:30 am

1 stop4h 00m

Knoxville McGhee Tyson

Sun 8/31

11:15 am-2:03 pm

1 stop3h 48m

$323

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 8/28

1:44 pm-2:50 pm

2 stops24h 06m

Knoxville McGhee Tyson

Mon 9/1

7:25 pm-1:03 pm

2 stops18h 38m

$687

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sun 8/10

6:00 am-11:08 am

1 stop4h 08m

$184

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Wed 7/23

5:30 am-10:28 am

1 stop3h 58m

$279

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sun 8/10

6:30 am-8:57 pm

2 stops13h 27m

$532

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/9

Best time to book a flight from Panama City to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Knoxville

What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $296). Flying from Panama City, Florida to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to TYS?

Find hourly flight availability from Panama City to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 9, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 9, 2025.
Read through reviews of airlines operating flights from Panama City to Knoxville, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,958 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,958 reviews
Delta
8.0
Very good
7,958 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,843 reviews
Delta
8.0
Very good
7,958 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,958 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City, Florida to Knoxville round-trip?

    Our cheapest airline available from Panama City, Florida to Knoxville is Delta. Our recent data shows that you can find tickets from as low as $283 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $323 and $687 round-trip. You may be able to fly from Panama City, Florida to Knoxville for 47% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Panama City, Florida to Knoxville one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $184. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Panama City, Florida to Knoxville for a low price.

  • Can I find deals for flights from Panama City to Knoxville that include hotel bookings?

    Yes. In addition to deals on Panama City to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Knoxville.

  • Can I find deals for business class flights from Panama City to Knoxville?

    Yes. Cheapflights offers flight deals from Panama City to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $296). Flying from Panama City, Florida to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Morristown
Corbin
Cherokee
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Panama City to Knoxville

Discover the top 2 airlines that operate flights from Panama City to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 9, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$286Average$529FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$312Average$518FlexibilityNo cancel feeOn-time71%

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