$125+ Cheap flights from Panama City, FL to Knoxville (ECP - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — TYS
may. 17 — may. 241
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Knoxville
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Best
Last-minute
One-way
Cheapest flights from Panama City to KnoxvilleExplore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 17, 2026.
Explore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 17, 2026.
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/87:50 am
ECP
- TYS
1 stop3h 10m
Southwest
sáb. 6/136:55 pm
TYS
- ECP
1 stop4h 00m
Southwest
Deal found 4/12![Southwest logo]()
$288
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/77:05 pm
ECP
- TYS
1 stop3h 41m
Delta
lun. 10/197:20 pm
TYS
- ECP
1 stop4h 27m
Delta
Deal found 4/13![Delta logo]()
$299
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/2012:00 pm
ECP
- TYS
1 stop8h 10m
Southwest
lun. 7/276:40 am
TYS
- ECP
1 stop3h 55m
Southwest
Deal found 4/14![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/105:55 am
ECP
- TYS
2 stops10h 45m
Southwest
sáb. 10/177:50 am
TYS
- ECP
2 stops8h 00m
Southwest
Deal found 4/13![Southwest logo]()
$309
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/107:05 am
ECP
- TYS
1 stop3h 35m
Southwest
mié. 5/132:55 pm
TYS
- ECP
1 stop6h 50m
Southwest
Deal found 4/12![Southwest logo]()
$313
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/79:55 am
ECP
- TYS
2 stops10h 20m
Southwest
mar. 5/127:05 am
TYS
- ECP
1 stop3h 25m
Southwest
Deal found 4/14![Southwest logo]()
$318
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/217:10 am
ECP
- TYS
1 stop3h 30m
Southwest
dom. 5/247:30 am
TYS
- ECP
2 stops10h 55m
Southwest
Deal found 4/14![Southwest logo]()
$320
Best flights from Panama City to KnoxvilleDiscover carefully curated flight deals from Panama City to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated abril 17, 2026.
Discover carefully curated flight deals from Panama City to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated abril 17, 2026.
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/87:50 am
ECP
- TYS
1 stop3h 10m
Southwest
sáb. 6/136:55 pm
TYS
- ECP
1 stop4h 00m
Southwest
Deal found 4/12![Southwest logo]()
$288
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/77:41 am
ECP
- TYS
1 stop4h 29m
Delta
dom. 5/105:40 am
TYS
- ECP
1 stop3h 50m
Delta
Deal found 4/15![Delta logo]()
$368
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/107:05 am
ECP
- TYS
1 stop3h 35m
Southwest
mié. 5/132:55 pm
TYS
- ECP
1 stop6h 50m
Southwest
Deal found 4/12![Southwest logo]()
$313
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/74:55 pm
ECP
- TYS
1 stop24h 16m
United Airlines
dom. 5/106:01 pm
TYS
- ECP
2 stops29h 04m
United Airlines
Deal found 4/15![United Airlines logo]()
$763
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/299:55 am
ECP
- TYS
2 stops10h 20m
Southwest
dom. 5/316:40 am
TYS
- ECP
2 stops6h 35m
Southwest
Deal found 4/12![Southwest logo]()
$348
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/86:00 am
ECP
- TYS
1 stop6h 10m
Delta
dom. 5/105:40 am
TYS
- ECP
1 stop3h 50m
Delta
Deal found 4/13![Delta logo]()
$398
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/216:40 am
ECP
- TYS
2 stops12h 40m
Southwest
dom. 5/247:30 am
TYS
- ECP
2 stops10h 55m
Southwest
Deal found 4/14![Southwest logo]()
$360
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/26:30 am
ECP
- TYS
1 stop15h 42m
United Airlines
sáb. 6/68:20 am
TYS
- ECP
1 stop26h 24m
United Airlines
Deal found 4/16![United Airlines logo]()
$791
Last-minute flights from Panama City to KnoxvilleDiscover last-minute flight deals from Panama City to Knoxville. Data last updated abril 17, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Knoxville. Data last updated abril 17, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/79:55 am
ECP
- TYS
1 stop9h 25m
Southwest
mar. 5/127:05 am
TYS
- ECP
1 stop3h 25m
Southwest
Deal found 4/14![Southwest logo]()
$318
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/77:41 am
ECP
- TYS
1 stop5h 52m
Delta
dom. 5/105:40 am
TYS
- ECP
1 stop3h 50m
Delta
Deal found 4/16![Delta logo]()
$368
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/86:45 pm
ECP
- TYS
1 stop4h 11m
Delta
dom. 5/105:40 am
TYS
- ECP
1 stop3h 50m
Delta
Deal found 4/16![Delta logo]()
$377
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/107:05 am
ECP
- TYS
1 stop3h 35m
Southwest
mié. 5/132:55 pm
TYS
- ECP
1 stop6h 50m
Southwest
Deal found 4/12![Southwest logo]()
$313
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/217:10 am
ECP
- TYS
1 stop3h 30m
Southwest
dom. 5/247:30 am
TYS
- ECP
2 stops10h 55m
Southwest
Deal found 4/14![Southwest logo]()
$320
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/299:55 am
ECP
- TYS
2 stops10h 20m
Southwest
dom. 5/316:40 am
TYS
- ECP
2 stops6h 35m
Southwest
Deal found 4/12![Southwest logo]()
$348
One-way flights from Panama City to KnoxvilleSearch for one-way flight options from Panama City to Knoxville. Find affordable one-way fares based on user searches. Data last updated abril 17, 2026.
Search for one-way flight options from Panama City to Knoxville. Find affordable one-way fares based on user searches. Data last updated abril 17, 2026.
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/196:00 am
ECP
- TYS
1 stop6h 10m
Delta
Deal found 4/16![Delta logo]()
$125
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/1910:10 am
ECP
- TYS
2 stops8h 30m
Southwest
Deal found 4/16![Southwest logo]()
$130
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/286:45 pm
ECP
- TYS
1 stop4h 02m
American Airlines
Deal found 4/16![American Airlines logo]()
$150
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/259:19 am
ECP
- TYS
1 stop4h 30m
Delta
Deal found 4/15![Delta logo]()
$160
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/251:25 pm
ECP
- TYS
2 stops6h 45m
Southwest
Deal found 4/15![Southwest logo]()
$165
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/289:55 am
ECP
- TYS
2 stops10h 20m
Southwest
Deal found 4/16![Southwest logo]()
$180
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/37:05 am
ECP
- TYS
1 stop3h 35m
Southwest
Deal found 4/16![Southwest logo]()
$219
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/67:15 am
ECP
- TYS
2 stops8h 55m
Southwest
Deal found 4/16![Southwest logo]()
$224
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/2211:40 am
ECP
- TYS
1 stop4h 31m
Delta
Deal found 4/17![Delta logo]()
$229
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/156:40 am
ECP
- TYS
2 stops12h 40m
Southwest
Deal found 4/13![Southwest logo]()
$249
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/226:40 am
ECP
- TYS
2 stops12h 40m
Southwest
Deal found 4/17![Southwest logo]()
$260
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/157:41 am
ECP
- TYS
1 stop5h 52m
Delta
Deal found 4/13![Delta logo]()
$270
Find flight deals from Panama City to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated abril 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $288 (Southwest) |
One-way from | $125 (Delta) |
Popular in | April |
Cheapest in | October |
Average price | $556 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 17, 2026.
Use the filters below to find and compare flights from Panama City to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
lun. 6/8
7:50 am-12:00 pm
1 stop3h 10m
Knoxville McGhee Tyson
sáb. 6/13
6:55 pm-9:55 pm
1 stop4h 00m
$288
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
dom. 5/10
7:05 am-11:40 am
1 stop3h 35m
Knoxville McGhee Tyson
mié. 5/13
2:55 pm-8:45 pm
1 stop6h 50m
$313
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
vie. 5/29
9:55 am-9:15 pm
2 stops10h 20m
Knoxville McGhee Tyson
dom. 5/31
6:40 am-12:15 pm
2 stops6h 35m
$348
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
jue. 5/21
6:40 am-8:20 pm
2 stops12h 40m
Knoxville McGhee Tyson
dom. 5/24
7:30 am-5:25 pm
2 stops10h 55m
$360
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
jue. 5/7
7:41 am-1:10 pm
1 stop4h 29m
Knoxville McGhee Tyson
dom. 5/10
5:40 am-8:30 am
1 stop3h 50m
$368
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
vie. 5/8
6:00 am-1:10 pm
1 stop6h 10m
Knoxville McGhee Tyson
dom. 5/10
5:40 am-8:30 am
1 stop3h 50m
$398
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
jue. 5/7
4:55 pm-6:11 pm
1 stop24h 16m
Knoxville McGhee Tyson
dom. 5/10
6:01 pm-10:05 pm
2 stops29h 04m
$763
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
mar. 6/2
6:30 am-11:12 pm
1 stop15h 42m
Knoxville McGhee Tyson
sáb. 6/6
8:20 am-9:44 am
1 stop26h 24m
$791
Cheapest one-way
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
mar. 5/19
6:00 am-1:10 pm
1 stop6h 10m
$125
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
mar. 5/19
10:10 am-7:40 pm
2 stops8h 30m
$130
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Panama City to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Knoxville in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Panama City with our price prediction graph.
ECP-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Knoxville
What is the cheapest month to book a flight from Panama City, Florida to Knoxville?
Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $326). Flying from Panama City, Florida to Knoxville in April is currently the most expensive (average of $556). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Panama City, Florida to Knoxville?
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated abril 17, 2026.
Read through reviews of airlines operating flights from Panama City to Knoxville, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.9
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.9
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.9
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Related info for your journey
Find useful and relevant information for your journey from Panama City to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on abril 17, 2026.
Panama City and Knoxville flights
Browse other Panama City and Knoxville flight options. Last updated on abril 17, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on abril 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Panama City to Knoxville
Discover the top 2 airlines that operate flights from Panama City to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$386 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$282 | Average$366 | FlexibilityNo cancel fee | On-time71% |