$214+ Cheap flights from Panama City, FL to Knoxville (ECP - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/18. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — TYS
Dec 11 — Dec 181
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Panama City to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to KnoxvilleExplore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 11, 2026.
Explore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 11, 2026.
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:00 am -
1 stop3h 06m
Mon 1/410:07 am -
1 stop3h 23m
Deal found 11/8![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:25 am -
1 stop5h 01m
Sun 11/298:04 pm -
1 stop4h 43m
Deal found 11/6![American Airlines logo]()
$467
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:00 am -
1 stop2h 55m
Thu 11/264:00 pm -
1 stop2h 57m
Deal found 11/7![Delta logo]()
$497
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2211:25 am -
2 stops9h 20m
Thu 11/2610:50 am -
1 stop5h 00m
Deal found 11/7![Southwest logo]()
$502
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/229:23 am -
1 stop5h 34m
Sun 12/274:52 pm -
1 stop3h 44m
Deal found 11/10![Delta logo]()
$559
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/317:36 am -
2 stops9h 41m
Mon 1/46:48 pm -
1 stop18h 14m
Deal found 11/7![American Airlines logo]()
$641
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:35 am -
2 stops8h 25m
Sat 11/286:30 am -
1 stop3h 25m
Deal found 11/9![Southwest logo]()
$652
Best flights from Panama City to KnoxvilleDiscover carefully curated flight deals from Panama City to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 11, 2026.
Discover carefully curated flight deals from Panama City to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 11, 2026.
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:00 am -
1 stop3h 06m
Mon 1/410:07 am -
1 stop3h 23m
Deal found 11/8![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:25 am -
1 stop5h 01m
Sun 11/298:04 pm -
1 stop4h 43m
Deal found 11/6![American Airlines logo]()
$467
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/810:40 am -
2 stops11h 10m
Sun 4/116:50 am -
2 stops9h 00m
Deal found 11/6![Southwest logo]()
$503
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/811:15 am -
1 stop3h 53m
Sun 4/115:30 am -
1 stop3h 47m
Deal found 11/6![Delta logo]()
$359
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:00 am -
1 stop2h 55m
Sun 11/2912:34 pm -
1 stop3h 32m
Deal found 11/10![Delta logo]()
$497
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:05 am -
1 stop3h 23m
Sat 11/288:35 am -
1 stop5h 07m
Deal found 11/9![Delta logo]()
$497
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/317:36 am -
2 stops9h 41m
Mon 1/48:01 pm -
1 stop4h 39m
Deal found 11/10![American Airlines logo]()
$645
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/229:23 am -
1 stop5h 34m
Sun 12/274:52 pm -
1 stop3h 44m
Deal found 11/10![Delta logo]()
$559
Last-minute flights from Panama City to KnoxvilleDiscover last-minute flight deals from Panama City to Knoxville. Data last updated November 11, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Knoxville. Data last updated November 11, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:00 am -
1 stop2h 55m
Thu 11/264:00 pm -
1 stop2h 57m
Deal found 11/7![Delta logo]()
$497
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2211:25 am -
2 stops9h 20m
Thu 11/2610:50 am -
1 stop5h 00m
Deal found 11/7![Southwest logo]()
$502
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:35 am -
2 stops8h 25m
Sat 11/286:30 am -
1 stop3h 25m
Deal found 11/9![Southwest logo]()
$652
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:25 am -
1 stop5h 01m
Sun 11/298:04 pm -
1 stop4h 43m
Deal found 11/6![American Airlines logo]()
$467
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/229:23 am -
1 stop5h 34m
Sun 12/274:52 pm -
1 stop3h 44m
Deal found 11/10![Delta logo]()
$559
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:00 am -
1 stop3h 06m
Mon 1/410:07 am -
1 stop3h 23m
Deal found 11/8![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/317:36 am -
2 stops9h 41m
Mon 1/46:48 pm -
1 stop18h 14m
Deal found 11/7![American Airlines logo]()
$641
One-way flights from Panama City to KnoxvilleSearch for one-way flight options from Panama City to Knoxville. Find affordable one-way fares based on user searches. Data last updated November 11, 2026.
Search for one-way flight options from Panama City to Knoxville. Find affordable one-way fares based on user searches. Data last updated November 11, 2026.
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/181:05 pm -
1 stop9h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Southwest logo]()
$214
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:25 pm -
1 stop3h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![Southwest logo]()
$249
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:25 am -
1 stop6h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![American Airlines logo]()
$318
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:49 pm -
1 stop4h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![American Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2211:25 am -
2 stops9h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Southwest logo]()
$349
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:55 am -
2 stops7h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![Southwest logo]()
$374
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/181:32 pm -
2 stops19h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![American Airlines logo]()
$421
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/182:10 pm -
3 stops29h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![United Airlines logo]()
$528
Find flight deals from Panama City to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $335 (Delta) |
One-way from | $214 (Southwest) |
Popular in | August |
Cheapest in | June |
Average price | $316 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 11, 2026.
Use the filters below to find and compare flights from Panama City to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Mon 1/18
1:05 pm-11:30 pm
1 stop9h 25m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$214
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Sun 11/22
6:00 am-11:28 am
1 stop4h 28m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$249
Quickest round-trip
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Sat 11/21
5:16 pm-10:12 pm
1 stop3h 56m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$249
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Sat 11/21
11:00 am-9:40 pm
2 stops9h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$254
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Sun 11/22
11:25 am-9:45 pm
2 stops9h 20m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$254
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Thu 12/31
6:00 am-10:06 am
1 stop3h 06m
Knoxville McGhee Tyson
Mon 1/4
10:07 am-12:30 pm
1 stop3h 23m
$335
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Sun 11/22
6:49 pm-11:59 pm
1 stop4h 10m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$344
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Thu 4/8
11:15 am-4:08 pm
1 stop3h 53m
Knoxville McGhee Tyson
Sun 4/11
5:30 am-8:17 am
1 stop3h 47m
$359
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Wed 11/25
7:25 am-1:26 pm
1 stop5h 01m
Knoxville McGhee Tyson
Sun 11/29
8:04 pm-11:47 pm
1 stop4h 43m
$467
Panama CityKnoxville
ECP Panama City NW Florida Beaches - TYS Knoxville McGhee Tyson
ECPTYS
Panama City NW Florida Beaches
Wed 11/25
6:00 am-9:55 am
1 stop2h 55m
Knoxville McGhee Tyson
Sun 11/29
12:34 pm-3:06 pm
1 stop3h 32m
$497
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Panama City to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Knoxville in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Panama City with our price prediction graph.
ECP-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 11, 2026.
Read through reviews of airlines operating flights from Panama City to Knoxville, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Food
7.2
Boarding
8.1
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Crew
8.5
Food
7.2
Boarding
8.1
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Panama City to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Newport
Bryson City
Crossville
Morristown
Murphy
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Other flights from Panama City
Popular flights
Alternative routes for Panama City to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama City to Knoxville by cabin class
Find flights from Panama City to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 11, 2026.
Panama City and Knoxville flights
Browse other Panama City and Knoxville flight options. Last updated on November 11, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on November 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama City to Knoxville
Discover the top airline that operate flights from Panama City to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$143 | Average$376 | FlexibilityNo cancel fee | On-timeN/A |