$135+ Cheap flights from Panama City, FL to Knoxville (ECP - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/30. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — TYS
Jul 13 — Jul 201
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Knoxville
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Cheapest flights from Panama City to KnoxvilleExplore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2026.
Explore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2026.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:40 am
ECP
- TYS
1 stop5h 51m
American Airlines
Sat 8/156:05 pm
TYS
- ECP
1 stop5h 35m
American Airlines
Deal found 6/10![American Airlines logo]()
$218
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:00 am
ECP
- TYS
1 stop5h 37m
American Airlines
Tue 7/2110:00 am
TYS
- ECP
1 stop6h 47m
American Airlines
Deal found 6/12![American Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Tue 7/217:10 am
TYS
- ECP
1 stop3h 20m
Southwest
Deal found 6/12![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:05 am
ECP
- TYS
1 stop3h 55m
Southwest
Fri 8/282:05 pm
TYS
- ECP
1 stop7h 55m
Southwest
Deal found 6/8![Southwest logo]()
$255
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:05 pm
ECP
- TYS
1 stop3h 41m
Delta
Mon 11/25:30 am
TYS
- ECP
1 stop3h 47m
Delta
Deal found 6/12![Delta logo]()
$259
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am
ECP
- TYS
1 stop4h 06m
Delta
Sun 11/17:20 pm
TYS
- ECP
1 stop4h 27m
Delta
Deal found 6/12![Delta logo]()
$279
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:50 am
ECP
- TYS
1 stop4h 26m
Delta
Mon 7/137:49 pm
TYS
- ECP
1 stop4h 48m
Delta
Deal found 6/9![Delta logo]()
$284
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Mon 7/136:40 am
TYS
- ECP
1 stop3h 55m
Southwest
Deal found 6/11![Southwest logo]()
$289
Best flights from Panama City to KnoxvilleDiscover carefully curated flight deals from Panama City to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 13, 2026.
Discover carefully curated flight deals from Panama City to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 13, 2026.
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:45 am
ECP
- TYS
1 stop3h 20m
Southwest
Sat 8/156:50 am
TYS
- ECP
2 stops6h 50m
Southwest
Deal found 6/10![Southwest logo]()
$255
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:00 am
ECP
- TYS
1 stop4h 11m
Delta
Fri 8/287:30 am
TYS
- ECP
1 stop4h 12m
Delta
Deal found 6/9![Delta logo]()
$255
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am
ECP
- TYS
1 stop4h 06m
Delta
Sun 11/17:20 pm
TYS
- ECP
1 stop4h 27m
Delta
Deal found 6/12![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Mon 7/1312:35 pm
TYS
- ECP
2 stops8h 40m
Southwest
Deal found 6/11![Southwest logo]()
$295
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:55 am
ECP
- TYS
2 stops13h 20m
Southwest
Sun 8/25:45 pm
TYS
- ECP
1 stop5h 20m
Southwest
Deal found 6/8![Southwest logo]()
$349
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:45 am
ECP
- TYS
1 stop3h 10m
Southwest
Wed 8/127:00 am
TYS
- ECP
1 stop3h 40m
Southwest
Deal found 6/8![Southwest logo]()
$368
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/256:00 am
ECP
- TYS
1 stop4h 09m
Delta
Sun 6/285:40 am
TYS
- ECP
1 stop3h 34m
Delta
Deal found 6/9![Delta logo]()
$437
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:25 am
ECP
- TYS
1 stop8h 05m
Southwest
Wed 11/2512:40 pm
TYS
- ECP
2 stops10h 50m
Southwest
Deal found 6/9![Southwest logo]()
$484
Last-minute flights from Panama City to KnoxvilleDiscover last-minute flight deals from Panama City to Knoxville. Data last updated June 13, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Knoxville. Data last updated June 13, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:50 am
ECP
- TYS
1 stop4h 26m
Delta
Mon 7/137:49 pm
TYS
- ECP
1 stop4h 48m
Delta
Deal found 6/9![Delta logo]()
$284
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Mon 7/136:40 am
TYS
- ECP
1 stop3h 55m
Southwest
Deal found 6/11![Southwest logo]()
$289
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:00 am
ECP
- TYS
1 stop5h 37m
American Airlines
Tue 7/2110:00 am
TYS
- ECP
1 stop6h 47m
American Airlines
Deal found 6/12![American Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Tue 7/217:10 am
TYS
- ECP
1 stop3h 20m
Southwest
Deal found 6/12![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/287:00 am
ECP
- TYS
1 stop6h 05m
Southwest
Sun 8/25:45 pm
TYS
- ECP
1 stop5h 20m
Southwest
Deal found 6/10![Southwest logo]()
$323
One-way flights from Panama City to KnoxvilleSearch for one-way flight options from Panama City to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 13, 2026.
Search for one-way flight options from Panama City to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 13, 2026.
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:08 pm
ECP
- TYS
1 stop3h 41m
Delta
Deal found 6/11![Delta logo]()
$135
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/307:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Deal found 6/11![Southwest logo]()
$140
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:50 am
ECP
- TYS
1 stop3h 10m
Southwest
Deal found 6/11![Southwest logo]()
$150
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/197:20 am
ECP
- TYS
2 stops13h 00m
Southwest
Deal found 6/8![Southwest logo]()
$161
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:50 am
ECP
- TYS
1 stop3h 10m
Southwest
Deal found 6/9![Southwest logo]()
$205
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/234:16 pm
ECP
- TYS
1 stop6h 31m
American Airlines
Deal found 6/9![American Airlines logo]()
$219
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/237:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Deal found 6/9![Southwest logo]()
$224
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/57:20 am
ECP
- TYS
2 stops13h 00m
Southwest
Deal found 6/9![Southwest logo]()
$249
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/182:46 pm
ECP
- TYS
1 stop4h 28m
Delta
Deal found 6/8![Delta logo]()
$314
Find flight deals from Panama City to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $218 (American Airlines) |
One-way from | $135 (Delta) |
Popular in | December |
Cheapest in | June |
Average price | $262 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
Use the filters below to find and compare flights from Panama City to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
Wed 8/12
7:45 am-12:05 pm
1 stop3h 20m
Knoxville McGhee Tyson
Sat 8/15
6:50 am-12:40 pm
2 stops6h 50m
$255
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
Mon 8/24
6:00 am-11:11 am
1 stop4h 11m
Knoxville McGhee Tyson
Fri 8/28
7:30 am-10:42 am
1 stop4h 12m
$255
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
Tue 10/27
6:00 am-11:06 am
1 stop4h 06m
Knoxville McGhee Tyson
Sun 11/1
7:20 pm-10:47 pm
1 stop4h 27m
$279
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
Tue 7/7
7:40 am-5:00 pm
2 stops8h 20m
Knoxville McGhee Tyson
Mon 7/13
12:35 pm-8:15 pm
2 stops8h 40m
$295
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
Fri 7/31
6:55 am-9:15 pm
2 stops13h 20m
Knoxville McGhee Tyson
Sun 8/2
5:45 pm-10:05 pm
1 stop5h 20m
$349
Quickest round-trip
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
Sat 8/8
7:45 am-11:55 am
1 stop3h 10m
Knoxville McGhee Tyson
Wed 8/12
7:00 am-9:40 am
1 stop3h 40m
$368
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
Thu 6/25
6:00 am-11:09 am
1 stop4h 09m
Knoxville McGhee Tyson
Sun 6/28
5:40 am-8:14 am
1 stop3h 34m
$437
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
Fri 11/20
11:25 am-8:30 pm
1 stop8h 05m
Knoxville McGhee Tyson
Wed 11/25
12:40 pm-10:30 pm
2 stops10h 50m
$484
Cheapest one-way
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
Tue 6/30
5:08 pm-9:49 pm
1 stop3h 41m
$135
Quickest one-way
Panama CityKnoxville
ECP - TYS
ECPTYS
Panama City NW Florida Beaches
Sat 7/4
7:20 am-11:50 am
1 stop3h 30m
$135
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Panama City to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Knoxville in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Panama City with our price prediction graph.
ECP-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 13, 2026.
Read through reviews of airlines operating flights from Panama City to Knoxville, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Overall
7.9
Food
7.2
Crew
8.5
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Overall
7.9
Food
7.2
Crew
8.5
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Overall
7.9
Food
7.2
Crew
8.5
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Related info for your journey
Find useful and relevant information for your journey from Panama City to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 13, 2026.
Panama City and Knoxville flights
Browse other Panama City and Knoxville flight options. Last updated on June 13, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on June 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Panama City to Knoxville
Discover the top 2 airlines that operate flights from Panama City to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$241 | Average$366 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$282 | Average$342 | FlexibilityNo cancel fee | On-time71% |