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$160+ Cheap flights from Charleston to Knoxville (CHS - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/21. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Jul 6 — Jul 131
Sun 7/6
Sun 7/13
1 adult, Economy
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Cheap flight deals from Charleston to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 1, 2025.

Round-trip from

$278
(Mytrip)

One-way from

$160
(Mytrip)

Popular in

August

Cheapest in

June

Average price

$520
From Charleston to Knoxville McGhee Tyson
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One-way flight from Charleston to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 11% potential increase in price ($66 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Charleston to Knoxville

Cheapest flights from Charleston to Knoxville
Explore the most affordable flight options available from Charleston to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

This Mytrip deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/146:41 pmCHS - TYS
2 stops18h 30mMultiple Airlines
Fri 7/188:52 amTYS - CHS
1 stop5h 53mMultiple Airlines
Deal found 6/29$272
This Mytrip deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/146:41 pmCHS - TYS
2 stops18h 30mAllegiant Air
Fri 7/181:12 pmTYS - CHS
2 stops18h 54mAllegiant Air
Deal found 6/29$293
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/46:20 amCHS - TYS
1 stop4h 05mDelta
Tue 10/74:00 pmTYS - CHS
1 stop2h 55mDelta
Deal found 6/29$297
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/285:00 amCHS - TYS
1 stop5h 28mAmerican Airlines
Mon 8/45:05 amTYS - CHS
1 stop3h 21mAmerican Airlines
Deal found 6/30$317
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1411:14 amCHS - TYS
2 stops12h 45mUnited Airlines
Mon 11/177:20 pmTYS - CHS
1 stop14h 48mUnited Airlines
Deal found 6/29$466

Cheapflights Fare Finder

Customize your flight search to find flights from Charleston to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
Use the filters below to find and compare flights from Charleston to Knoxville that are best for you.

Fly from

Charleston

Fly to

Knoxville

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 7/14

6:41 pm-1:11 pm

2 stops18h 30m

Knoxville McGhee Tyson

Fri 7/18

8:52 am-2:45 pm

1 stop5h 53m

$272

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 7/14

6:41 pm-1:11 pm

2 stops18h 30m

Knoxville McGhee Tyson

Fri 7/18

1:12 pm-8:06 am

2 stops18h 54m

$293

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 10/4

6:20 am-10:25 am

1 stop4h 05m

Knoxville McGhee Tyson

Tue 10/7

4:00 pm-6:55 pm

1 stop2h 55m

$297

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 7/28

5:00 am-10:28 am

1 stop5h 28m

Knoxville McGhee Tyson

Mon 8/4

5:05 am-8:26 am

1 stop3h 21m

$317

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 11/14

11:14 am-11:59 pm

2 stops12h 45m

Knoxville McGhee Tyson

Mon 11/17

7:20 pm-10:08 am

1 stop14h 48m

$466

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 7/21

6:41 pm-1:11 pm

2 stops18h 30m

$160

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 7/21

9:38 am-12:26 pm

2 stops26h 48m

$164

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 7/22

12:53 pm-5:24 pm

1 stop4h 31m

$217

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 7/12

12:47 pm-6:02 pm

1 stop5h 15m

$279

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 7/23

11:20 am-8:57 pm

2 stops9h 37m

$462

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Charleston to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Knoxville

What is the cheapest month to book a flight from Charleston to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $296). Flying from Charleston to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to TYS?

Find hourly flight availability from Charleston to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

When flying from Charleston to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 25% versus a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 1, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Charleston to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,974 reviews

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,974 reviews
Delta
8.0
Very good
7,974 reviews

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,858 reviews
Delta
8.0
Very good
7,974 reviews

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,974 reviews

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
710 reviews
Delta
8.0
Very good
7,974 reviews

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Charleston to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Charleston to Knoxville round-trip?

    Flying on Delta is currently your cheapest option to Knoxville, with prices starting at $297. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $317 and $466, respectively. You may be able to fly from Charleston to Knoxville for 44% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Charleston to Knoxville one-way?

    The cheapest airlines for a one-way flight from Charleston to Knoxville are Allegiant Air ($160), Delta ($217), and American Airlines ($279).

  • Can I find deals for flights from Charleston to Knoxville that include hotel bookings?

    Yes. In addition to deals on Charleston to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Knoxville.

  • Can I find deals for business class flights from Charleston to Knoxville?

    Yes. Cheapflights offers flight deals from Charleston to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Charleston to Knoxville (average of $296). Flying from Charleston to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

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Top 2 airlines flying from Charleston to Knoxville

Discover the top 2 airlines that operate flights from Charleston to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$346Average$504FlexibilityNo cancel feeOn-time71%
DeltaCheapest$356Average$560FlexibilityNo cancel feeOn-timeN/A

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