$135+ Cheap flights from Knoxville to Charleston (TYS - CHS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Oct 17 — Oct 241
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Charleston with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Charleston
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Cheapest flights from Knoxville to CharlestonExplore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:01 am -
1 stop3h 47m
Sun 11/155:05 am -
1 stop5h 25m
Deal found 9/14![American Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:54 am -
1 stop10h 02m
Tue 9/293:00 pm -
1 stop23h 42m
Deal found 9/13![Multiple Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:00 am -
1 stop24h 38m
Mon 10/264:57 pm -
1 stop24h 17m
Deal found 9/14![Multiple Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:00 pm -
1 stop3h 15m
Sun 10/186:30 am -
1 stop3h 04m
Deal found 9/16![Delta logo]()
$376
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2812:22 pm -
1 stop20h 16m
Fri 10/24:57 pm -
1 stop15h 38m
Deal found 9/13![Multiple Airlines logo]()
$377
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:40 am -
1 stop3h 45m
Sat 10/246:29 pm -
1 stop3h 53m
Deal found 9/14![Delta logo]()
$381
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:56 pm -
1 stop15h 28m
Sun 10/410:13 pm -
1 stop12h 22m
Deal found 9/16![Multiple Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:58 pm -
1 stop3h 59m
Thu 10/155:02 am -
1 stop3h 30m
Deal found 9/15![American Airlines logo]()
$415
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:54 am -
1 stop10h 02m
Sun 9/272:13 pm -
1 stop26h 30m
Deal found 9/15![Multiple Airlines logo]()
$417
Best flights from Knoxville to CharlestonDiscover carefully curated flight deals from Knoxville to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from Knoxville to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:40 am -
1 stop3h 45m
Sat 10/246:29 pm -
1 stop3h 53m
Deal found 9/14![Delta logo]()
$381
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:15 am -
1 stop5h 37m
Sat 10/35:31 pm -
1 stop3h 35m
Deal found 9/14![American Airlines logo]()
$467
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:00 am -
1 stop5h 50m
Sat 10/310:45 am -
2 stops8h 50m
Deal found 9/14![Southwest logo]()
$472
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:00 am -
2 stops25h 38m
Sun 10/410:13 pm -
1 stop12h 22m
Deal found 9/16![Multiple Airlines logo]()
$476
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:40 am -
1 stop4h 30m
Sun 10/186:30 am -
1 stop3h 04m
Deal found 9/13![Delta logo]()
$417
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:39 am -
1 stop5h 34m
Wed 10/76:30 am -
1 stop3h 04m
Deal found 9/12![Delta logo]()
$451
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:15 am -
2 stops14h 30m
Mon 10/264:45 pm -
2 stops6h 00m
Deal found 9/14![Southwest logo]()
$499
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:54 pm -
2 stops18h 44m
Sun 9/272:13 pm -
1 stop26h 30m
Deal found 9/15![Multiple Airlines logo]()
$556
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:10 am -
2 stops11h 25m
Tue 9/297:35 am -
2 stops11h 25m
Deal found 9/16![Southwest logo]()
$613
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:40 am -
1 stop5h 58m
Sat 9/266:26 pm -
1 stop4h 01m
Deal found 9/15![Delta logo]()
$597
Last-minute flights from Knoxville to CharlestonDiscover last-minute flight deals from Knoxville to Charleston. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Charleston. Data last updated September 17, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:54 am -
1 stop10h 02m
Tue 9/293:00 pm -
1 stop23h 42m
Deal found 9/13![Multiple Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:54 am -
1 stop10h 02m
Sun 9/272:13 pm -
1 stop26h 30m
Deal found 9/15![Multiple Airlines logo]()
$417
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2812:22 pm -
1 stop20h 16m
Fri 10/24:57 pm -
1 stop15h 38m
Deal found 9/13![Multiple Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:56 pm -
1 stop15h 28m
Sun 10/410:13 pm -
1 stop12h 22m
Deal found 9/16![Multiple Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:58 pm -
1 stop3h 59m
Thu 10/155:02 am -
1 stop3h 30m
Deal found 9/15![American Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:00 pm -
1 stop3h 15m
Sun 10/186:30 am -
1 stop3h 04m
Deal found 9/16![Delta logo]()
$376
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:00 am -
1 stop24h 38m
Mon 10/264:57 pm -
1 stop24h 17m
Deal found 9/14![Multiple Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:40 am -
1 stop3h 45m
Sat 10/246:29 pm -
1 stop3h 53m
Deal found 9/14![Delta logo]()
$381
One-way flights from Knoxville to CharlestonSearch for one-way flight options from Knoxville to Charleston. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
Search for one-way flight options from Knoxville to Charleston. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:15 am -
1 stop9h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Multiple Airlines logo]()
$135
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:07 pm -
1 stop3h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/111:58 pm -
3 stops48h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$159
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:40 am -
1 stop3h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Delta logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/229:49 pm -
1 stop10h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$202
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/117:05 am -
2 stops12h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Southwest logo]()
$205
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:15 am -
1 stop3h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![American Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:15 am -
2 stops13h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Allegiant Air logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:15 am -
1 stop9h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$242
Find flight deals from Knoxville to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $303 (American Airlines) |
One-way from | $135 (Kiwi.com) |
Popular in | October |
Cheapest in | September |
Average price | $318 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Thu 10/15
6:15 am-4:11 pm
1 stop9h 56m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$135
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Fri 12/11
6:07 pm-9:53 pm
1 stop3h 46m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$152
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Fri 12/11
1:58 pm-2:10 pm
3 stops48h 12m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$159
Quickest round-trip
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Sun 11/22
5:40 am-8:43 am
1 stop3h 03m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$191
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Sun 11/22
9:49 pm-8:48 am
1 stop10h 59m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$202
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Fri 12/11
7:05 am-7:15 pm
2 stops12h 10m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$205
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Wed 9/30
6:15 am-9:47 am
1 stop3h 32m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$234
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Thu 10/15
6:15 am-7:44 pm
2 stops13h 29m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$237
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Sat 10/24
5:40 am-9:25 am
1 stop3h 45m
Charleston
Sat 10/24
6:29 pm-10:22 pm
1 stop3h 53m
$381
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Sun 10/11
5:40 am-10:10 am
1 stop4h 30m
Charleston
Sun 10/18
6:30 am-9:34 am
1 stop3h 04m
$417
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Charleston in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from Knoxville with our price prediction graph.
TYS-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Charleston
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated September 17, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Charleston to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Mount Pleasant
Goose Creek
Edisto Beach
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Other flights to Charleston
Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 17, 2026.
Complete your trip
Complete your trip to Charleston by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and Charleston flights
Browse other Knoxville and Charleston flight options. Last updated on September 17, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Charleston
Discover the top 2 airlines that operate flights from Knoxville to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$279 | Average$548 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$427 | FlexibilityNo cancel fee | On-timeN/A |