$117+ Cheap flights from Knoxville to Charleston (TYS - CHS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
May 23 — May 301
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Charleston with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Charleston
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to CharlestonExplore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
Explore the most affordable flight options available from Knoxville to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:05 pm
TYS
- CHS
1 stop4h 49m
American Airlines
Tue 8/187:41 pm
CHS
- TYS
1 stop3h 17m
American Airlines
Deal found 4/20![American Airlines logo]()
$221
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:00 am
TYS
- CHS
1 stop4h 35m
Southwest
Tue 8/187:35 am
CHS
- TYS
2 stops11h 20m
Southwest
Deal found 4/20![Southwest logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:42 pm
TYS
- CHS
1 stop17h 03m
Multiple Airlines
Tue 6/163:13 pm
CHS
- TYS
1 stop27h 08m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:00 pm
TYS
- CHS
1 stop20h 28m
Multiple Airlines
Mon 6/153:23 pm
CHS
- TYS
1 stop8h 11m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:20 pm
TYS
- CHS
1 stop13h 18m
Multiple Airlines
Thu 7/97:47 pm
CHS
- TYS
1 stop22h 43m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$275
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/248:30 am
TYS
- CHS
1 stop6h 00m
Southwest
Wed 5/272:25 pm
CHS
- TYS
1 stop6h 25m
Southwest
Deal found 4/20![Southwest logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/247:20 pm
TYS
- CHS
1 stop13h 28m
Multiple Airlines
Mon 7/273:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- CHS
1 stop19h 23m
Multiple Airlines
Mon 5/253:23 pm
CHS
- TYS
1 stop8h 14m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$304
Best flights from Knoxville to CharlestonDiscover carefully curated flight deals from Knoxville to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
Discover carefully curated flight deals from Knoxville to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:42 pm
TYS
- CHS
1 stop17h 03m
Multiple Airlines
Tue 6/163:13 pm
CHS
- TYS
1 stop27h 08m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$251
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:40 am
TYS
- CHS
1 stop3h 58m
Delta
Thu 5/285:15 am
CHS
- TYS
1 stop4h 19m
Delta
Deal found 4/23![Delta logo]()
$326
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:59 pm
TYS
- CHS
1 stop4h 00m
American Airlines
Wed 6/35:00 am
CHS
- TYS
1 stop5h 36m
American Airlines
Deal found 4/19![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:40 am
TYS
- CHS
1 stop6h 00m
Southwest
Mon 6/228:00 am
CHS
- TYS
2 stops13h 10m
Southwest
Deal found 4/22![Southwest logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- CHS
1 stop19h 23m
Multiple Airlines
Mon 5/253:23 pm
CHS
- TYS
1 stop8h 14m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1112:35 pm
TYS
- CHS
2 stops9h 00m
Southwest
Tue 6/168:20 am
CHS
- TYS
2 stops12h 00m
Southwest
Deal found 4/18![Southwest logo]()
$353
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:30 am
TYS
- CHS
2 stops14h 05m
Southwest
Sat 6/136:30 am
CHS
- TYS
1 stop5h 25m
Southwest
Deal found 4/22![Southwest logo]()
$358
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:59 pm
TYS
- CHS
1 stop4h 57m
Delta
Wed 5/136:15 am
CHS
- TYS
1 stop3h 19m
Delta
Deal found 4/19![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:35 am
TYS
- CHS
2 stops12h 45m
Southwest
Thu 5/281:15 pm
CHS
- TYS
2 stops8h 00m
Southwest
Deal found 4/23![Southwest logo]()
$403
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:35 am
TYS
- CHS
1 stop6h 00m
Southwest
Sun 5/316:15 am
CHS
- TYS
1 stop5h 25m
Southwest
Deal found 4/21![Southwest logo]()
$417
Last-minute flights from Knoxville to CharlestonDiscover last-minute flight deals from Knoxville to Charleston. Data last updated April 23, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Charleston. Data last updated April 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:15 pm
TYS
- CHS
1 stop20h 18m
Multiple Airlines
Fri 5/82:39 pm
CHS
- TYS
2 stops20h 27m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/91:59 pm
TYS
- CHS
1 stop18h 39m
Multiple Airlines
Tue 5/1210:17 am
CHS
- TYS
2 stops24h 19m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1712:55 pm
TYS
- CHS
2 stops29h 05m
Multiple Airlines
Sun 5/242:53 pm
CHS
- TYS
1 stop24h 19m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$326
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- CHS
1 stop19h 23m
Multiple Airlines
Mon 5/253:23 pm
CHS
- TYS
1 stop8h 14m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/218:38 pm
TYS
- CHS
2 stops36h 10m
Multiple Airlines
Thu 5/288:20 pm
CHS
- TYS
1 stop26h 11m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$312
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:40 am
TYS
- CHS
2 stops7h 25m
Southwest
Sat 5/307:00 am
CHS
- TYS
2 stops11h 30m
Southwest
Deal found 4/23![Southwest logo]()
$317
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/248:30 am
TYS
- CHS
1 stop6h 00m
Southwest
Wed 5/272:25 pm
CHS
- TYS
1 stop6h 25m
Southwest
Deal found 4/20![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:30 am
TYS
- CHS
2 stops13h 20m
Southwest
Sat 5/307:00 am
CHS
- TYS
2 stops11h 30m
Southwest
Deal found 4/23![Southwest logo]()
$323
One-way flights from Knoxville to CharlestonSearch for one-way flight options from Knoxville to Charleston. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
Search for one-way flight options from Knoxville to Charleston. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:15 pm
TYS
- CHS
1 stop19h 33m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/193:48 pm
TYS
- CHS
1 stop17h 50m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:02 pm
TYS
- CHS
2 stops19h 36m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:10 am
TYS
- CHS
1 stop27h 58m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/79:40 pm
TYS
- CHS
2 stops35h 08m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:24 pm
TYS
- CHS
1 stop13h 24m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$168
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:59 pm
TYS
- CHS
1 stop3h 49m
American Airlines
Deal found 4/19![American Airlines logo]()
$169
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/198:15 am
TYS
- CHS
2 stops9h 25m
Southwest
Deal found 4/18![Southwest logo]()
$174
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1212:11 pm
TYS
- CHS
1 stop3h 27m
American Airlines
Deal found 4/19![American Airlines logo]()
$189
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:15 am
TYS
- CHS
2 stops11h 45m
Southwest
Deal found 4/19![Southwest logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:13 pm
TYS
- CHS
2 stops25h 47m
Allegiant Air
Deal found 4/22![Allegiant Air logo]()
$211
Find flight deals from Knoxville to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $221 (American Airlines) |
One-way from | $117 (Kiwi.com) |
Popular in | January |
Cheapest in | August |
Average price | $356 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Thu 6/11
3:42 pm-8:45 am
1 stop17h 03m
Charleston
Tue 6/16
3:13 pm-6:21 pm
1 stop27h 08m
$251
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Mon 5/18
1:15 pm-8:38 am
1 stop19h 23m
Charleston
Mon 5/25
3:23 pm-11:37 pm
1 stop8h 14m
$304
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Thu 5/21
5:40 am-9:38 am
1 stop3h 58m
Charleston
Thu 5/28
5:15 am-9:34 am
1 stop4h 19m
$326
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Mon 6/1
7:59 pm-11:59 pm
1 stop4h 00m
Charleston
Wed 6/3
5:00 am-10:36 am
1 stop5h 36m
$337
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Thu 6/18
6:40 am-12:40 pm
1 stop6h 00m
Charleston
Mon 6/22
8:00 am-9:10 pm
2 stops13h 10m
$348
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Thu 6/11
12:35 pm-9:35 pm
2 stops9h 00m
Charleston
Tue 6/16
8:20 am-8:20 pm
2 stops12h 00m
$353
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Thu 6/11
7:30 am-9:35 pm
2 stops14h 05m
Charleston
Sat 6/13
6:30 am-11:55 am
1 stop5h 25m
$358
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Thu 5/21
6:35 am-7:20 pm
2 stops12h 45m
Charleston
Thu 5/28
1:15 pm-9:15 pm
2 stops8h 00m
$403
Quickest round-trip
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Fri 5/8
5:59 pm-10:56 pm
1 stop4h 57m
Charleston
Wed 5/13
6:15 am-9:34 am
1 stop3h 19m
$407
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Fri 5/29
6:35 am-12:35 pm
1 stop6h 00m
Charleston
Sun 5/31
6:15 am-11:40 am
1 stop5h 25m
$417
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Charleston in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from Knoxville with our price prediction graph.
TYS-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Charleston
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated April 23, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Charleston to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Boarding
8.1
Food
7.2
Comfort
7.9
Overall
7.9
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Boarding
8.1
Food
7.2
Comfort
7.9
Overall
7.9
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Boarding
8.1
Food
7.2
Comfort
7.9
Overall
7.9
Crew
8.5
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Walterboro
Summerville
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach
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Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 23, 2026.
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Top 2 airlines flying from Knoxville to Charleston
Discover the top 2 airlines that operate flights from Knoxville to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$296 | Average$476 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$402 | FlexibilityNo cancel fee | On-timeN/A |