$105+ Cheap flights from Knoxville (TYS) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Sep 8 — Sep 151
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to South Carolina with Cheapflights
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Cheapest flights from Knoxville to South CarolinaExplore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 9, 2026.
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 9, 2026.
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:05 pm -
1 stop3h 21m
Fri 9/115:45 pm -
1 stop5h 05m
Deal found 8/9![American Airlines logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:46 pm -
1 stop22h 09m
Sat 9/512:19 pm -
1 stop21h 45m
Deal found 8/4![Multiple Airlines logo]()
$211
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:15 am -
1 stop4h 25m
Mon 8/317:33 pm -
1 stop3h 25m
Deal found 8/5![American Airlines logo]()
$221
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:07 am -
1 stop47h 18m
Mon 9/78:27 am -
Nonstop1h 16m
Deal found 8/7![American Airlines logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:51 pm -
1 stop17h 10m
Sun 8/309:52 pm -
1 stop21h 11m
Deal found 8/8![Multiple Airlines logo]()
$238
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:00 am -
2 stops12h 15m
Sat 9/51:10 pm -
1 stop6h 15m
Deal found 8/4![Southwest logo]()
$240
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2911:15 am -
1 stop45h 20m
Mon 8/3110:25 am -
Nonstop1h 19m
Deal found 8/5![American Airlines logo]()
$242
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2911:15 am -
1 stop20h 44m
Sun 8/309:10 am -
Nonstop1h 20m
Deal found 8/7![American Airlines logo]()
$247
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:45 pm -
1 stop4h 10m
Tue 9/156:50 am -
1 stop5h 15m
Deal found 8/5![Southwest logo]()
$251
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:40 am -
1 stop4h 30m
Fri 10/3012:40 pm -
1 stop4h 47m
Deal found 8/7![Delta logo]()
$251
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:40 am -
1 stop3h 36m
Sun 9/66:00 am -
1 stop3h 44m
Deal found 8/4![Delta logo]()
$254
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2410:55 am -
1 stop43h 32m
Mon 10/269:05 am -
Nonstop1h 18m
Deal found 8/9![American Airlines logo]()
$257
Best flights from Knoxville to South CarolinaDiscover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 9, 2026.
Discover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 9, 2026.
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:00 am -
2 stops12h 15m
Sat 9/51:10 pm -
1 stop6h 15m
Deal found 8/6![Southwest logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:21 pm -
1 stop27h 35m
Mon 9/143:27 pm -
1 stop5h 12m
Deal found 8/8![Multiple Airlines logo]()
$251
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:40 am -
1 stop3h 36m
Sun 9/66:00 am -
1 stop3h 44m
Deal found 8/4![Delta logo]()
$254
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:15 am -
1 stop5h 54m
Thu 8/273:27 pm -
1 stop3h 33m
Deal found 8/6![American Airlines logo]()
$412
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/57:05 am -
1 stop5h 50m
Thu 1/76:45 am -
1 stop5h 25m
Deal found 8/7![Southwest logo]()
$247
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:00 pm -
1 stop4h 17m
Sat 11/77:10 am -
1 stop3h 43m
Deal found 8/4![Delta logo]()
$267
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:45 pm -
1 stop4h 10m
Tue 9/156:50 am -
1 stop5h 15m
Deal found 8/5![Southwest logo]()
$251
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:40 am -
1 stop4h 28m
Wed 9/162:12 pm -
1 stop3h 16m
Deal found 8/6![Delta logo]()
$269
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/217:35 pm -
1 stop23h 14m
Mon 1/257:35 pm -
1 stop23h 42m
Deal found 8/7![United Airlines logo]()
$615
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:46 pm -
2 stops20h 33m
Fri 9/42:36 pm -
1 stop8h 20m
Deal found 8/8![Multiple Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:50 am -
2 stops8h 50m
Fri 9/113:20 pm -
1 stop4h 40m
Deal found 8/6![Southwest logo]()
$267
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:24 pm -
1 stop3h 27m
Wed 10/286:30 am -
1 stop3h 10m
Deal found 8/5![Delta logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/181:37 pm -
2 stops31h 19m
Sun 10/2510:05 pm -
1 stop21h 19m
Deal found 8/4![Multiple Airlines logo]()
$330
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:23 pm -
1 stop5h 34m
Fri 10/162:46 pm -
1 stop3h 53m
Deal found 8/5![Delta logo]()
$292
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/48:10 am -
1 stop6h 50m
Thu 1/76:45 am -
1 stop5h 25m
Deal found 8/7![Southwest logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:28 am -
2 stops14h 08m
Sun 10/410:05 pm -
1 stop21h 19m
Deal found 8/8![Multiple Airlines logo]()
$348
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:24 pm -
1 stop4h 35m
Fri 10/306:30 am -
1 stop4h 24m
Deal found 8/8![Delta logo]()
$297
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:08 am -
1 stop6h 30m
Sun 9/65:46 pm -
1 stop4h 04m
Deal found 8/8![American Airlines logo]()
$456
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:25 pm -
2 stops14h 45m
Thu 10/294:45 pm -
1 stop4h 45m
Deal found 8/4![Southwest logo]()
$319
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:40 am -
1 stop3h 34m
Sun 9/135:30 am -
1 stop3h 59m
Deal found 8/4![Delta logo]()
$316
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:01 am -
1 stop6h 06m
Sun 11/225:54 pm -
1 stop6h 05m
Deal found 8/4![American Airlines logo]()
$479
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:15 am -
2 stops12h 10m
Wed 10/288:10 am -
2 stops8h 30m
Deal found 8/5![Southwest logo]()
$344
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:25 pm -
1 stop3h 10m
Sun 9/205:30 am -
1 stop5h 48m
Deal found 8/6![Delta logo]()
$321
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:50 am -
1 stop7h 35m
Mon 9/76:35 am -
1 stop5h 45m
Deal found 8/7![Southwest logo]()
$345
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:45 am -
1 stop24h 02m
Mon 9/77:54 pm -
1 stop24h 30m
Deal found 8/4![United Airlines logo]()
$615
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/209:58 am -
1 stop4h 23m
Sun 9/276:29 pm -
1 stop3h 24m
Deal found 8/6![American Airlines logo]()
$525
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:25 pm -
1 stop4h 34m
Sun 9/205:25 am -
1 stop4h 04m
Deal found 8/6![Delta logo]()
$338
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2710:16 am -
1 stop13h 26m
Sat 1/302:40 pm -
1 stop24h 02m
Deal found 8/5![United Airlines logo]()
$625
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:10 am -
2 stops10h 25m
Mon 8/316:35 am -
1 stop5h 45m
Deal found 8/5![Southwest logo]()
$359
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/291:59 pm -
2 stops24h 22m
Sat 9/57:54 pm -
1 stop14h 43m
Deal found 8/6![United Airlines logo]()
$634
Last-minute flights from Knoxville to South CarolinaDiscover last-minute flight deals from Knoxville to South Carolina. Data last updated August 9, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South Carolina. Data last updated August 9, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:51 pm -
1 stop17h 10m
Sun 8/309:52 pm -
1 stop21h 11m
Deal found 8/8![Multiple Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:51 pm -
1 stop19h 14m
Fri 8/281:13 pm -
1 stop5h 52m
Deal found 8/8![Multiple Airlines logo]()
$261
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:15 am -
1 stop4h 25m
Mon 8/317:33 pm -
1 stop3h 25m
Deal found 8/5![American Airlines logo]()
$221
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2911:15 am -
1 stop45h 20m
Mon 8/3110:25 am -
Nonstop1h 19m
Deal found 8/5![American Airlines logo]()
$242
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2911:15 am -
1 stop20h 44m
Sun 8/309:10 am -
Nonstop1h 20m
Deal found 8/7![American Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:46 pm -
1 stop22h 09m
Sat 9/512:19 pm -
1 stop21h 45m
Deal found 8/4![Multiple Airlines logo]()
$211
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:00 am -
2 stops12h 15m
Sat 9/51:10 pm -
1 stop6h 15m
Deal found 8/4![Southwest logo]()
$240
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:40 am -
1 stop3h 36m
Sun 9/66:00 am -
1 stop3h 44m
Deal found 8/4![Delta logo]()
$254
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:05 pm -
1 stop3h 21m
Fri 9/115:45 pm -
1 stop5h 05m
Deal found 8/9![American Airlines logo]()
$211
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:07 am -
1 stop47h 18m
Mon 9/78:27 am -
Nonstop1h 16m
Deal found 8/7![American Airlines logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:21 pm -
1 stop27h 35m
Mon 9/143:27 pm -
1 stop5h 12m
Deal found 8/8![Multiple Airlines logo]()
$251
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:45 pm -
1 stop4h 10m
Tue 9/156:50 am -
1 stop5h 15m
Deal found 8/5![Southwest logo]()
$251
One-way flights from Knoxville to South CarolinaSearch for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 9, 2026.
Search for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:54 am -
1 stop5h 21m
Deal found 8/7![Multiple Airlines logo]()
$105
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/261:45 pm -
1 stop3h 53m
Deal found 8/7![American Airlines logo]()
$106
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:10 pm -
1 stop3h 20m
Deal found 8/7![Southwest logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:54 am -
1 stop5h 21m
Deal found 8/8![Multiple Airlines logo]()
$118
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:00 am -
1 stop3h 11m
Deal found 8/4![Delta logo]()
$121
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:50 am -
1 stop7h 35m
Deal found 8/5![Southwest logo]()
$122
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:30 am -
1 stop3h 17m
Deal found 8/7![Delta logo]()
$124
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:45 pm -
1 stop4h 10m
Deal found 8/6![Southwest logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:21 pm -
1 stop18h 40m
Deal found 8/4![Multiple Airlines logo]()
$127
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:50 am -
2 stops8h 50m
Deal found 8/5![Southwest logo]()
$129
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:10 am -
2 stops8h 25m
Deal found 8/7![Southwest logo]()
$129
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:25 pm -
1 stop3h 10m
Deal found 8/4![Delta logo]()
$134
Find flight deals from Knoxville to South Carolina
Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated August 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $211 (American Airlines) |
One-way from | $105 (Kiwi.com) |
Popular in | March |
Cheapest in | August |
Average price | $278 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 9, 2026.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSavannah
TYS Knoxville McGhee Tyson - SAV Savannah/Hilton Head
TYSSAV
Knoxville McGhee Tyson
Wed 9/2
7:00 am-7:15 pm
2 stops12h 15m
Savannah/Hilton Head
Sat 9/5
1:10 pm-7:25 pm
1 stop6h 15m
$240
KnoxvilleSavannah
TYS Knoxville McGhee Tyson - SAV Savannah/Hilton Head
TYSSAV
Knoxville McGhee Tyson
Tue 1/5
7:05 am-12:55 pm
1 stop5h 50m
Savannah/Hilton Head
Thu 1/7
6:45 am-12:10 pm
1 stop5h 25m
$247
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Thu 9/10
5:21 pm-8:56 pm
1 stop27h 35m
Charleston
Mon 9/14
3:27 pm-8:39 pm
1 stop5h 12m
$251
KnoxvilleCharlotte
TYS Knoxville McGhee Tyson - CLT Charlotte Douglas
TYSCLT
Knoxville McGhee Tyson
Fri 9/11
5:45 pm-9:55 pm
1 stop4h 10m
Charlotte Douglas
Tue 9/15
6:50 am-12:05 pm
1 stop5h 15m
$251
KnoxvilleSavannah
TYS Knoxville McGhee Tyson - SAV Savannah/Hilton Head
TYSSAV
Knoxville McGhee Tyson
Thu 9/3
5:40 am-9:16 am
1 stop3h 36m
Savannah/Hilton Head
Sun 9/6
6:00 am-9:44 am
1 stop3h 44m
$254
KnoxvilleSavannah
TYS Knoxville McGhee Tyson - SAV Savannah/Hilton Head
TYSSAV
Knoxville McGhee Tyson
Sat 10/31
5:00 pm-9:17 pm
1 stop4h 17m
Savannah/Hilton Head
Sat 11/7
7:10 am-10:53 am
1 stop3h 43m
$267
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Sat 9/5
6:50 am-3:40 pm
2 stops8h 50m
Myrtle Beach Intl
Fri 9/11
3:20 pm-8:00 pm
1 stop4h 40m
$267
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Mon 9/14
5:40 am-10:08 am
1 stop4h 28m
Charleston
Wed 9/16
2:12 pm-5:28 pm
1 stop3h 16m
$269
Quickest round-trip
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Fri 10/23
7:24 pm-10:51 pm
1 stop3h 27m
Charleston
Wed 10/28
6:30 am-9:40 am
1 stop3h 10m
$289
KnoxvilleSavannah
TYS Knoxville McGhee Tyson - SAV Savannah/Hilton Head
TYSSAV
Knoxville McGhee Tyson
Tue 10/13
6:23 pm-11:57 pm
1 stop5h 34m
Savannah/Hilton Head
Fri 10/16
2:46 pm-6:39 pm
1 stop3h 53m
$292
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
TYS-SAV
TYS-CLT
TYS-MYR
TYS-CHS
TYS-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South Carolina
TYS-USSC
TYS-SAV
TYS-CLT
TYS-MYR
TYS-CHS
What is the cheapest month to book a flight from Knoxville to South Carolina?
Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $307). Flying from Knoxville to South Carolina in January is currently the most expensive (average of $601). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 9, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to South Carolina
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Complete your trip
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Knoxville and South Carolina flights
Browse other Knoxville and South Carolina flight options. Last updated on August 9, 2026.
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Knoxville to South Carolina flights
Consider these flights traveling from Knoxville to South Carolina.
Top 2 airlines flying from Knoxville to South Carolina
Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$467 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$374 | FlexibilityNo cancel fee | On-timeN/A |