$74+ Cheap flights from Knoxville (TYS) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/29. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Jun 12 — Jun 191
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to South Carolina with Cheapflights
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Cheapest flights from Knoxville to South CarolinaExplore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 13, 2026.
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 13, 2026.
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:46 pm
TYS
- CLT
1 stop4h 13m
Delta
Wed 6/175:30 am
CLT
- TYS
1 stop4h 23m
Delta
Deal found 5/12![Delta logo]()
$147
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:40 am
TYS
- CLT
1 stop5h 52m
Delta
Wed 6/175:30 am
CLT
- TYS
1 stop4h 23m
Delta
Deal found 5/12![Delta logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/810:03 pm
TYS
- CHS
1 stop10h 35m
Multiple Airlines
Fri 6/129:28 pm
CHS
- TYS
1 stop25h 25m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$216
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:27 am
TYS
- CLT
1 stop3h 33m
Delta
Tue 5/268:01 am
CLT
- TYS
1 stop5h 09m
Delta
Deal found 5/12![Delta logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/810:03 pm
TYS
- CHS
1 stop10h 35m
Multiple Airlines
Mon 6/153:23 pm
CHS
- TYS
1 stop8h 11m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:45 am
TYS
- SAV
1 stop6h 10m
Multiple Airlines
Sun 8/91:53 pm
SAV
- TYS
2 stops32h 51m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$267
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/304:43 pm
TYS
- CLT
1 stop15h 21m
American Airlines
Sun 5/3111:10 am
CLT
- TYS
Nonstop1h 14m
American Airlines
Deal found 5/10![American Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/274:52 pm
TYS
- MYR
1 stop16h 58m
Multiple Airlines
Sat 9/53:17 pm
MYR
- TYS
1 stop18h 47m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:02 pm
TYS
- MYR
1 stop26h 35m
Multiple Airlines
Fri 6/122:28 pm
MYR
- TYS
1 stop9h 06m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$283
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- MYR
1 stop5h 04m
Delta
Tue 7/76:00 am
MYR
- TYS
1 stop5h 05m
Delta
Deal found 5/12![Delta logo]()
$295
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:40 am
TYS
- SAV
1 stop3h 39m
Delta
Tue 6/168:09 am
SAV
- TYS
1 stop5h 10m
Delta
Deal found 5/12![Delta logo]()
$295
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:00 am
TYS
- CHS
1 stop3h 23m
American Airlines
Wed 7/291:00 pm
CHS
- TYS
1 stop4h 36m
American Airlines
Deal found 5/12![American Airlines logo]()
$295
Best flights from Knoxville to South CarolinaDiscover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 13, 2026.
Discover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 13, 2026.
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:46 pm
TYS
- CLT
1 stop4h 13m
Delta
Wed 6/175:30 am
CLT
- TYS
1 stop4h 23m
Delta
Deal found 5/12![Delta logo]()
$147
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/118:00 am
TYS
- MYR
1 stop5h 25m
Southwest
Wed 7/152:10 pm
MYR
- TYS
1 stop7h 05m
Southwest
Deal found 5/11![Southwest logo]()
$316
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:59 pm
TYS
- SAV
1 stop4h 00m
American Airlines
Mon 6/86:26 pm
SAV
- TYS
1 stop5h 33m
American Airlines
Deal found 5/11![American Airlines logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:27 pm
TYS
- CLT
2 stops26h 08m
Multiple Airlines
Sun 6/149:37 am
CLT
- TYS
1 stop10h 52m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$333
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:40 am
TYS
- CLT
1 stop3h 16m
Delta
Wed 5/275:35 am
CLT
- TYS
1 stop5h 34m
Delta
Deal found 5/12![Delta logo]()
$247
This Southwest deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/28:15 am
TYS
- MYR
1 stop7h 10m
Southwest
Tue 6/98:30 am
MYR
- TYS
2 stops11h 50m
Southwest
Deal found 5/12![Southwest logo]()
$319
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:33 pm
TYS
- MYR
1 stop4h 25m
Delta
Tue 6/97:57 pm
MYR
- TYS
1 stop3h 57m
Delta
Deal found 5/12![Delta logo]()
$295
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:59 pm
TYS
- SAV
1 stop4h 00m
American Airlines
Mon 6/226:26 pm
SAV
- TYS
1 stop5h 33m
American Airlines
Deal found 5/13![American Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:02 pm
TYS
- CLT
2 stops19h 40m
Multiple Airlines
Wed 6/177:58 pm
CLT
- TYS
1 stop26h 31m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
TYS
- CAE
2 stops13h 09m
United Airlines
Wed 6/106:25 am
CAE
- TYS
1 stop14h 31m
United Airlines
Deal found 5/9![United Airlines logo]()
$682
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/75:45 pm
TYS
- SAV
1 stop4h 10m
Southwest
Tue 8/118:00 am
SAV
- TYS
2 stops10h 55m
Southwest
Deal found 5/8![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:46 pm
TYS
- MYR
1 stop4h 13m
Delta
Mon 6/157:57 pm
MYR
- TYS
1 stop3h 57m
Delta
Deal found 5/11![Delta logo]()
$321
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:55 pm
TYS
- CLT
1 stop3h 10m
Southwest
Tue 6/1610:40 am
CLT
- TYS
2 stops9h 40m
Southwest
Deal found 5/10![Southwest logo]()
$321
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:55 am
TYS
- HHH
1 stop4h 15m
American Airlines
Tue 6/165:21 pm
HHH
- TYS
1 stop6h 26m
American Airlines
Deal found 5/12![American Airlines logo]()
$368
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/187:00 am
TYS
- CLT
1 stop5h 25m
Southwest
Tue 7/2111:50 am
CLT
- TYS
1 stop8h 30m
Southwest
Deal found 5/10![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:33 pm
TYS
- MYR
1 stop4h 25m
Delta
Wed 6/106:00 am
MYR
- TYS
1 stop5h 09m
Delta
Deal found 5/12![Delta logo]()
$336
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:10 am
TYS
- MYR
1 stop10h 15m
Southwest
Thu 7/92:00 pm
MYR
- TYS
2 stops7h 10m
Southwest
Deal found 5/9![Southwest logo]()
$327
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/34:00 pm
TYS
- SAV
1 stop4h 53m
Delta
Sun 9/65:30 am
SAV
- TYS
1 stop3h 41m
Delta
Deal found 5/9![Delta logo]()
$337
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:15 am
TYS
- HHH
1 stop4h 54m
American Airlines
Thu 9/35:46 pm
HHH
- TYS
1 stop4h 09m
American Airlines
Deal found 5/8![American Airlines logo]()
$428
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:00 am
TYS
- MYR
2 stops9h 10m
Southwest
Sat 6/133:50 pm
MYR
- TYS
1 stop5h 30m
Southwest
Deal found 5/9![Southwest logo]()
$334
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:13 am
TYS
- HHH
1 stop3h 00m
American Airlines
Sat 10/176:13 pm
HHH
- TYS
1 stop5h 17m
American Airlines
Deal found 5/10![American Airlines logo]()
$432
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/68:00 am
TYS
- CHS
1 stop7h 25m
Southwest
Fri 6/124:10 pm
CHS
- TYS
1 stop6h 20m
Southwest
Deal found 5/9![Southwest logo]()
$334
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:40 am
TYS
- CAE
1 stop3h 45m
Delta
Mon 6/151:47 pm
CAE
- TYS
1 stop4h 58m
Delta
Deal found 5/11![Delta logo]()
$377
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:15 am
TYS
- HHH
1 stop2h 55m
American Airlines
Sun 9/136:07 pm
HHH
- TYS
1 stop6h 03m
American Airlines
Deal found 5/12![American Airlines logo]()
$446
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:10 am
TYS
- SAV
2 stops8h 25m
Southwest
Mon 8/247:40 am
SAV
- TYS
2 stops10h 55m
Southwest
Deal found 5/11![Southwest logo]()
$337
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:40 am
TYS
- CHS
1 stop3h 58m
Delta
Sun 6/75:10 am
CHS
- TYS
1 stop4h 28m
Delta
Deal found 5/11![Delta logo]()
$377
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:30 am
TYS
- CAE
1 stop10h 22m
United Airlines
Wed 5/272:51 pm
CAE
- TYS
1 stop23h 36m
United Airlines
Deal found 5/8![United Airlines logo]()
$707
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:00 am
TYS
- CAE
1 stop3h 16m
American Airlines
Sat 5/305:00 am
CAE
- TYS
1 stop3h 34m
American Airlines
Deal found 5/11![American Airlines logo]()
$447
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:45 pm
TYS
- CLT
1 stop3h 30m
Southwest
Fri 6/264:00 pm
CLT
- TYS
1 stop5h 10m
Southwest
Deal found 5/8![Southwest logo]()
$337
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:19 pm
TYS
- CAE
2 stops15h 20m
United Airlines
Mon 6/156:25 am
CAE
- TYS
1 stop27h 18m
United Airlines
Deal found 5/11![United Airlines logo]()
$707
Last-minute flights from Knoxville to South CarolinaDiscover last-minute flight deals from Knoxville to South Carolina. Data last updated May 13, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South Carolina. Data last updated May 13, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:27 am
TYS
- CLT
1 stop3h 33m
Delta
Tue 5/268:01 am
CLT
- TYS
1 stop5h 09m
Delta
Deal found 5/12![Delta logo]()
$247
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/304:43 pm
TYS
- CLT
1 stop15h 21m
American Airlines
Sun 5/3111:10 am
CLT
- TYS
Nonstop1h 14m
American Airlines
Deal found 5/10![American Airlines logo]()
$268
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:59 pm
TYS
- SAV
1 stop4h 00m
American Airlines
Tue 6/25:09 am
SAV
- TYS
1 stop5h 27m
American Airlines
Deal found 5/8![American Airlines logo]()
$297
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/68:00 am
TYS
- MYR
1 stop5h 25m
Southwest
Tue 6/162:10 pm
MYR
- TYS
1 stop7h 05m
Southwest
Deal found 5/8![Southwest logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/810:03 pm
TYS
- CHS
1 stop10h 35m
Multiple Airlines
Fri 6/129:28 pm
CHS
- TYS
1 stop25h 25m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/810:03 pm
TYS
- CHS
1 stop10h 35m
Multiple Airlines
Mon 6/153:23 pm
CHS
- TYS
1 stop8h 11m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:02 pm
TYS
- MYR
1 stop26h 35m
Multiple Airlines
Fri 6/122:28 pm
MYR
- TYS
1 stop9h 06m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$283
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:40 am
TYS
- SAV
1 stop3h 39m
Delta
Tue 6/168:09 am
SAV
- TYS
1 stop5h 10m
Delta
Deal found 5/12![Delta logo]()
$295
This Southwest deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/98:10 am
TYS
- CHS
2 stops12h 15m
Southwest
Tue 6/163:00 pm
CHS
- TYS
1 stop6h 15m
Southwest
Deal found 5/12![Southwest logo]()
$300
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:40 am
TYS
- CLT
1 stop5h 52m
Delta
Wed 6/175:30 am
CLT
- TYS
1 stop4h 23m
Delta
Deal found 5/12![Delta logo]()
$162
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:46 pm
TYS
- CLT
1 stop4h 13m
Delta
Wed 6/175:30 am
CLT
- TYS
1 stop4h 23m
Delta
Deal found 5/12![Delta logo]()
$147
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- MYR
1 stop5h 04m
Delta
Tue 7/76:00 am
MYR
- TYS
1 stop5h 05m
Delta
Deal found 5/12![Delta logo]()
$295
One-way flights from Knoxville to South CarolinaSearch for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 13, 2026.
Search for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 13, 2026.
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:35 am
TYS
- CLT
1 stop3h 51m
Delta
Deal found 5/12![Delta logo]()
$74
This Delta deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:27 am
TYS
- CLT
1 stop3h 39m
Delta
Deal found 5/13![Delta logo]()
$89
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:27 pm
TYS
- CHS
1 stop13h 11m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:15 am
TYS
- SAV
1 stop6h 40m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:05 pm
TYS
- CLT
1 stop22h 57m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:11 pm
TYS
- SAV
1 stop20h 44m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:02 pm
TYS
- SAV
1 stop24h 53m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2410:05 pm
TYS
- CHS
1 stop10h 43m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/37:20 pm
TYS
- CLT
2 stops22h 29m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:40 pm
TYS
- CLT
3 stops32h 55m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:02 pm
TYS
- MYR
1 stop26h 35m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/512:40 pm
TYS
- MYR
2 stops32h 29m
Allegiant Air
Deal found 5/12![Allegiant Air logo]()
$140
Find flight deals from Knoxville to South Carolina
Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated May 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $147 (Delta) |
One-way from | $74 (Delta) |
Popular in | March |
Cheapest in | August |
Average price | $330 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleCharlotte
TYS - CLT
TYSCLT
Knoxville McGhee Tyson
Thu 6/11
7:46 pm-11:59 pm
1 stop4h 13m
Charlotte Douglas
Wed 6/17
5:30 am-9:53 am
1 stop4h 23m
$147
KnoxvilleCharlotte
TYS - CLT
TYSCLT
Knoxville McGhee Tyson
Fri 5/22
5:40 am-8:56 am
1 stop3h 16m
Charlotte Douglas
Wed 5/27
5:35 am-11:09 am
1 stop5h 34m
$247
KnoxvilleMyrtle Beach
TYS - MYR
TYSMYR
Knoxville McGhee Tyson
Tue 6/2
7:33 pm-11:58 pm
1 stop4h 25m
Myrtle Beach Intl
Tue 6/9
7:57 pm-11:54 pm
1 stop3h 57m
$295
KnoxvilleMyrtle Beach
TYS - MYR
TYSMYR
Knoxville McGhee Tyson
Sat 7/11
8:00 am-1:25 pm
1 stop5h 25m
Myrtle Beach Intl
Wed 7/15
2:10 pm-9:15 pm
1 stop7h 05m
$316
KnoxvilleMyrtle Beach
TYS - MYR
TYSMYR
Knoxville McGhee Tyson
Tue 6/2
8:15 am-3:25 pm
1 stop7h 10m
Myrtle Beach Intl
Tue 6/9
8:30 am-8:20 pm
2 stops11h 50m
$319
KnoxvilleSavannah
TYS - SAV
TYSSAV
Knoxville McGhee Tyson
Thu 6/4
7:59 pm-11:59 pm
1 stop4h 00m
Savannah/Hilton Head
Mon 6/8
6:26 pm-11:59 pm
1 stop5h 33m
$321
KnoxvilleSavannah
TYS - SAV
TYSSAV
Knoxville McGhee Tyson
Fri 8/7
5:45 pm-9:55 pm
1 stop4h 10m
Savannah/Hilton Head
Tue 8/11
8:00 am-6:55 pm
2 stops10h 55m
$321
KnoxvilleMyrtle Beach
TYS - MYR
TYSMYR
Knoxville McGhee Tyson
Mon 6/8
7:46 pm-11:59 pm
1 stop4h 13m
Myrtle Beach Intl
Mon 6/15
7:57 pm-11:54 pm
1 stop3h 57m
$321
KnoxvilleCharlotte
TYS - CLT
TYSCLT
Knoxville McGhee Tyson
Tue 6/9
6:55 pm-10:05 pm
1 stop3h 10m
Charlotte Douglas
Tue 6/16
10:40 am-8:20 pm
2 stops9h 40m
$321
KnoxvilleCharlotte
TYS - CLT
TYSCLT
Knoxville McGhee Tyson
Sat 7/18
7:00 am-12:25 pm
1 stop5h 25m
Charlotte Douglas
Tue 7/21
11:50 am-8:20 pm
1 stop8h 30m
$321
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
TYS-CLT
TYS-CHS
TYS-SAV
TYS-MYR
TYS-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South Carolina
TYS-USSC
TYS-CLT
TYS-CHS
TYS-SAV
TYS-MYR
What is the cheapest month to book a flight from Knoxville to South Carolina?
Currently, June is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $125). Flying from Knoxville to South Carolina in January is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 13, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Crew
8.5
Overall
7.9
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Crew
8.5
Overall
7.9
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Crew
8.5
Overall
7.9
Food
7.2
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and South Carolina flights
Browse other Knoxville and South Carolina flight options. Last updated on May 13, 2026.
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Knoxville to South Carolina flights
Consider these flights traveling from Knoxville to South Carolina.
Top 2 airlines flying from Knoxville to South Carolina
Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$401 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$238 | Average$382 | FlexibilityNo cancel fee | On-timeN/A |