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South Carolina

$98+ Cheap flights from Knoxville (TYS) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/11. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Aug 8 — Aug 151
Sat 8/8
Sat 8/15
1 adult, Economy
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Cheap flight deals from Knoxville to South Carolina

Cheapest flights from Knoxville to South Carolina
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 9, 2026.

This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:05 pm
TYS
-
MYR
1 stop4h 33m
American Airlines
Mon 8/107:33 pm
MYR
-
TYS
1 stop3h 25m
American Airlines
Deal found 7/8$179
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:25 pm
TYS
-
MYR
1 stop3h 17m
American Airlines
Fri 8/287:33 pm
MYR
-
TYS
1 stop3h 25m
American Airlines
Deal found 7/7$180
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:08 am
TYS
-
CHS
1 stop3h 08m
American Airlines
Sat 8/296:15 am
CHS
-
TYS
1 stop3h 28m
American Airlines
Deal found 7/7$195
This Delta deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:00 pm
TYS
-
MYR
1 stop4h 49m
Delta
Sat 8/296:00 am
MYR
-
TYS
1 stop3h 33m
Delta
Deal found 7/7$209
This Kiwi.com deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1212:56 pm
TYS
-
SAV
1 stop24h 59m
Multiple Airlines
Wed 8/1912:19 pm
SAV
-
TYS
1 stop21h 45m
Multiple Airlines
Deal found 7/7$210
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:52 pm
TYS
-
MYR
1 stop16h 58m
Multiple Airlines
Sun 8/237:14 pm
MYR
-
TYS
1 stop23h 21m
Multiple Airlines
Deal found 7/6$216
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:15 am
TYS
-
MYR
1 stop6h 09m
American Airlines
Mon 8/247:33 pm
MYR
-
TYS
1 stop3h 25m
American Airlines
Deal found 7/7$221
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:15 am
TYS
-
SAV
1 stop4h 44m
American Airlines
Wed 8/128:00 am
SAV
-
TYS
1 stop3h 44m
American Airlines
Deal found 7/7$221
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:15 am
TYS
-
CHS
1 stop4h 24m
American Airlines
Mon 8/104:06 pm
CHS
-
TYS
1 stop4h 53m
American Airlines
Deal found 7/7$221
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:45 pm
TYS
-
SAV
1 stop4h 10m
Southwest
Thu 8/276:50 am
SAV
-
TYS
1 stop5h 10m
Southwest
Deal found 7/7$222
This Southwest deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:30 pm
TYS
-
CLT
1 stop3h 55m
Southwest
Thu 9/101:05 pm
CLT
-
TYS
1 stop6h 50m
Southwest
Deal found 7/8$222
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:05 pm
TYS
-
SAV
1 stop3h 39m
American Airlines
Wed 8/1212:55 pm
SAV
-
TYS
1 stop4h 39m
American Airlines
Deal found 7/8$223

Find flight deals from Knoxville to South Carolina

Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated July 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$179
(American Airlines)

One-way from

$98
(Delta)

Popular in

March

Cheapest in

August

Average price

$366
Provider with most accurate pricing for Knoxville McGhee Tyson-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Myrtle Beach Intl flights.
Search Deals
From Knoxville McGhee Tyson to South Carolina
Search Deals
One-way flight from Knoxville McGhee Tyson to South Carolina
Search Deals
High demand for flights, 0% potential price rise
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 9, 2026.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Wed 9/9

5:30 pm-9:25 pm

1 stop3h 55m

Charlotte Douglas

Thu 9/10

1:05 pm-7:55 pm

1 stop6h 50m

$222

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 8/5

12:01 pm-4:00 pm

1 stop3h 59m

Charleston

Wed 8/12

9:48 am-3:30 pm

1 stop5h 42m

$223

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Wed 8/12

7:00 am-7:15 pm

2 stops12h 15m

Savannah/Hilton Head

Wed 8/19

6:45 am-12:05 pm

1 stop5h 20m

$233

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sat 9/19

6:50 am-7:20 pm

2 stops12h 30m

Charleston

Tue 9/29

6:45 am-12:05 pm

1 stop5h 20m

$233

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 8/5

8:05 am-7:45 pm

2 stops11h 40m

Charleston

Wed 8/12

6:45 am-12:05 pm

1 stop5h 20m

$245
Quickest round-trip

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 8/7

7:25 pm-10:38 pm

1 stop3h 13m

Myrtle Beach Intl

Sun 8/9

5:00 am-8:38 am

1 stop3h 38m

$258

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sun 9/6

6:00 am-10:47 am

1 stop4h 47m

Myrtle Beach Intl

Sun 9/13

6:59 pm-11:55 pm

1 stop4h 56m

$274

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 8/21

7:10 am-7:40 pm

2 stops12h 30m

Myrtle Beach Intl

Fri 8/28

3:20 pm-7:55 pm

1 stop4h 35m

$291

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 8/6

8:25 am-7:10 pm

2 stops10h 45m

Charleston

Mon 8/10

6:35 am-12:20 pm

1 stop5h 45m

$291

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Thu 9/10

6:00 am-9:14 am

1 stop3h 14m

Savannah/Hilton Head

Sun 9/13

5:30 am-11:23 am

1 stop5h 53m

$299

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/8

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Knoxville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South Carolina

What is the cheapest month to book a flight from Knoxville to South Carolina?

Currently, September is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $196). Flying from Knoxville to South Carolina in January is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 9, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,453 reviews

Comfort

7.8

Boarding

8.1

Food

7.2

Overall

7.8

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Delta
7.8
Good
8,453 reviews
Delta
7.8
Good
8,453 reviews

Comfort

7.8

Boarding

8.1

Food

7.2

Overall

7.8

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
American Airlines
7.1
Good
11,789 reviews
Delta
7.8
Good
8,453 reviews

Comfort

7.8

Boarding

8.1

Food

7.2

Overall

7.8

Entertainment

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South Carolina?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to South Carolina. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to South Carolina?

    Airlines like Southwest, Delta, and American Airlines fly from Knoxville to South Carolina in about 3h 13m. The time it takes to get you to your destination can typically vary by up to 46m. The distance between Knoxville and South Carolina is about 323 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to South Carolina?

    The most popular route from Knoxville to South Carolina is Knoxville McGhee Tyson - Myrtle Beach Intl. You may also consider Knoxville McGhee Tyson - Savannah/Hilton Head or Knoxville McGhee Tyson - Charlotte Douglas.

  • Can I find deals for flights from Knoxville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Knoxville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South Carolina.

  • Can I find deals for business class flights from Knoxville to South Carolina?

    Yes. Cheapflights offers flight deals from Knoxville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South Carolina?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $196). Flying from Knoxville to South Carolina in January is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to South Carolina

Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$224Average$424FlexibilityNo cancel feeOn-time71%
DeltaCheapest$238Average$397FlexibilityNo cancel feeOn-timeN/A

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