$133+ Cheap flights from Knoxville (TYS) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Dec 10 — Dec 171
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to South Carolina with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to South CarolinaExplore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am -
2 stops25h 38m
Mon 11/233:27 pm -
1 stop8h 02m
Deal found 11/5![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:49 pm -
1 stop12h 16m
Mon 12/141:53 pm -
1 stop23h 14m
Deal found 11/9![Multiple Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/82:13 pm -
1 stop4h 32m
Tue 12/158:02 am -
1 stop3h 49m
Deal found 11/8![American Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:55 am -
1 stop4h 50m
Tue 12/1511:00 am -
2 stops9h 50m
Deal found 11/8![Southwest logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am -
2 stops37h 07m
Tue 11/243:51 pm -
1 stop7h 32m
Deal found 11/5![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:42 pm -
1 stop21h 48m
Mon 11/303:04 pm -
1 stop19h 08m
Deal found 11/5![Allegiant Air logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/68:00 am -
1 stop24h 45m
Sun 12/136:25 pm -
1 stop26h 22m
Deal found 11/8![Multiple Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/209:08 pm -
1 stop10h 55m
Mon 12/211:53 pm -
1 stop9h 21m
Deal found 11/8![Multiple Airlines logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am -
2 stops25h 38m
Tue 11/244:50 pm -
1 stop17h 58m
Deal found 11/5![Multiple Airlines logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:42 pm -
1 stop21h 48m
Mon 11/308:52 pm -
2 stops18h 50m
Deal found 11/5![Multiple Airlines logo]()
$360
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:20 am -
2 stops25h 18m
Mon 11/164:57 pm -
1 stop24h 21m
Deal found 11/4![Multiple Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:13 pm -
1 stop12h 00m
Tue 11/249:13 pm -
1 stop13h 35m
Deal found 11/5![Multiple Airlines logo]()
$404
Best flights from Knoxville to South CarolinaDiscover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
Discover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/255:40 am -
1 stop3h 49m
Mon 3/17:02 pm -
1 stop4h 55m
Deal found 11/5![Delta logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am -
2 stops37h 07m
Tue 11/243:51 pm -
1 stop7h 32m
Deal found 11/5![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:42 pm -
1 stop21h 48m
Mon 11/303:04 pm -
1 stop19h 08m
Deal found 11/5![Allegiant Air logo]()
$318
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/76:45 am -
2 stops8h 35m
Tue 1/126:40 am -
1 stop5h 35m
Deal found 11/7![Southwest logo]()
$329
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/55:15 pm -
1 stop3h 58m
Sun 2/76:05 am -
1 stop3h 42m
Deal found 11/6![American Airlines logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:30 am -
1 stop25h 08m
Mon 11/233:27 pm -
1 stop8h 02m
Deal found 11/5![Multiple Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/44:43 pm -
1 stop3h 10m
Wed 2/1011:00 am -
1 stop4h 49m
Deal found 11/7![Delta logo]()
$324
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/47:40 am -
1 stop10h 40m
Wed 2/106:40 am -
2 stops13h 05m
Deal found 11/7![Southwest logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/68:00 am -
1 stop24h 45m
Sun 12/136:25 pm -
2 stops24h 17m
Deal found 11/8![Multiple Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/76:01 am -
2 stops11h 47m
Mon 1/116:29 pm -
3 stops20h 18m
Deal found 11/5![United Airlines logo]()
$769
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2110:05 am -
1 stop4h 50m
Sun 4/251:05 pm -
1 stop4h 08m
Deal found 11/9![Delta logo]()
$377
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/156:40 am -
2 stops11h 40m
Tue 1/196:40 am -
2 stops10h 25m
Deal found 11/5![Southwest logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:42 pm -
1 stop21h 48m
Mon 11/308:52 pm -
2 stops18h 50m
Deal found 11/5![Multiple Airlines logo]()
$360
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:31 am -
1 stop5h 13m
Mon 11/304:59 pm -
1 stop4h 42m
Deal found 11/5![American Airlines logo]()
$467
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/128:20 am -
1 stop6h 02m
Mon 2/155:37 am -
1 stop3h 40m
Deal found 11/9![Delta logo]()
$397
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/306:55 am -
2 stops9h 15m
Fri 4/91:25 pm -
2 stops9h 25m
Deal found 11/5![Southwest logo]()
$423
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:01 pm -
1 stop2h 53m
Mon 11/308:35 pm -
1 stop3h 24m
Deal found 11/6![American Airlines logo]()
$467
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/127:00 am -
1 stop10h 57m
Mon 2/153:30 pm -
1 stop26h 24m
Deal found 11/6![Multiple Airlines logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:13 pm -
1 stop12h 00m
Tue 11/249:13 pm -
1 stop13h 35m
Deal found 11/5![Multiple Airlines logo]()
$404
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/266:38 am -
1 stop4h 00m
Sat 12/267:05 pm -
1 stop4h 48m
Deal found 11/9![American Airlines logo]()
$535
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/202:47 pm -
1 stop3h 12m
Sun 11/225:34 pm -
1 stop4h 48m
Deal found 11/4![Delta logo]()
$497
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/207:00 am -
2 stops11h 40m
Mon 12/218:05 am -
2 stops14h 35m
Deal found 11/8![Southwest logo]()
$534
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:40 am -
1 stop4h 34m
Sun 11/299:23 am -
1 stop4h 32m
Deal found 11/7![Delta logo]()
$497
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/312:20 pm -
1 stop9h 22m
Sat 4/37:35 pm -
1 stop14h 25m
Deal found 11/7![United Airlines logo]()
$785
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:40 am -
1 stop4h 33m
Thu 11/262:28 pm -
1 stop4h 55m
Deal found 11/9![Delta logo]()
$497
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:40 am -
1 stop3h 03m
Sun 11/297:04 pm -
1 stop4h 53m
Deal found 11/6![Delta logo]()
$497
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:53 am -
3 stops26h 01m
Sun 12/610:00 am -
1 stop9h 47m
Deal found 11/6![United Airlines logo]()
$831
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:40 am -
1 stop3h 41m
Tue 11/241:59 pm -
1 stop4h 50m
Deal found 11/5![Delta logo]()
$507
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/129:40 am -
2 stops11h 34m
Mon 2/156:00 am -
1 stop14h 22m
Deal found 11/9![United Airlines logo]()
$905
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:35 pm -
2 stops18h 05m
Mon 11/307:43 pm -
2 stops21h 17m
Deal found 11/9![United Airlines logo]()
$945
Last-minute flights from Knoxville to South CarolinaDiscover last-minute flight deals from Knoxville to South Carolina. Data last updated November 10, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South Carolina. Data last updated November 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:20 am -
2 stops25h 18m
Mon 11/164:57 pm -
1 stop24h 21m
Deal found 11/4![Multiple Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am -
2 stops25h 38m
Mon 11/233:27 pm -
1 stop8h 02m
Deal found 11/5![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am -
2 stops37h 07m
Tue 11/243:51 pm -
1 stop7h 32m
Deal found 11/5![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am -
2 stops25h 38m
Tue 11/244:50 pm -
1 stop17h 58m
Deal found 11/5![Multiple Airlines logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:13 pm -
1 stop12h 00m
Tue 11/249:13 pm -
1 stop13h 35m
Deal found 11/5![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:42 pm -
1 stop21h 48m
Mon 11/303:04 pm -
1 stop19h 08m
Deal found 11/5![Allegiant Air logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:42 pm -
1 stop21h 48m
Mon 11/308:52 pm -
2 stops18h 50m
Deal found 11/5![Multiple Airlines logo]()
$360
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/68:00 am -
1 stop24h 45m
Sun 12/136:25 pm -
1 stop26h 22m
Deal found 11/8![Multiple Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:49 pm -
1 stop12h 16m
Mon 12/141:53 pm -
1 stop23h 14m
Deal found 11/9![Multiple Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/82:13 pm -
1 stop4h 32m
Tue 12/158:02 am -
1 stop3h 49m
Deal found 11/8![American Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:55 am -
1 stop4h 50m
Tue 12/1511:00 am -
2 stops9h 50m
Deal found 11/8![Southwest logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/209:08 pm -
1 stop10h 55m
Mon 12/211:53 pm -
1 stop9h 21m
Deal found 11/8![Multiple Airlines logo]()
$337
One-way flights from Knoxville to South CarolinaSearch for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
Search for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:42 pm -
1 stop21h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Allegiant Air logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:32 pm -
1 stop26h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/234:31 pm -
1 stop27h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Multiple Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:51 pm -
1 stop22h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![Allegiant Air logo]()
$159
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/42:36 pm -
1 stop5h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Delta logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:32 pm -
2 stops16h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![Multiple Airlines logo]()
$186
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/236:55 am -
2 stops9h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Southwest logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:00 am -
2 stops46h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am -
2 stops28h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:00 am -
2 stops8h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/249:51 pm -
2 stops39h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Multiple Airlines logo]()
$235
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:40 am -
1 stop6h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Delta logo]()
$249
Find flight deals from Knoxville to South Carolina
Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated November 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $265 (Kiwi.com) |
One-way from | $133 (Kiwi.com) |
Popular in | March |
Cheapest in | July |
Average price | $515 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 10, 2026.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleGreenville
TYS Knoxville McGhee Tyson - GSP Greenville
TYSGSP
Knoxville McGhee Tyson
Mon 11/23
7:42 pm-5:30 pm
1 stop21h 48m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$133
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Tue 3/23
4:31 pm-7:54 pm
1 stop27h 23m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$159
KnoxvilleGreenville
TYS Knoxville McGhee Tyson - GSP Greenville
TYSGSP
Knoxville McGhee Tyson
Sat 11/21
4:51 pm-2:52 pm
1 stop22h 01m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$159
KnoxvilleGreenville
TYS Knoxville McGhee Tyson - GSP Greenville
TYSGSP
Knoxville McGhee Tyson
Fri 12/4
2:36 pm-7:57 pm
1 stop5h 21m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$180
KnoxvilleGreenville
TYS Knoxville McGhee Tyson - GSP Greenville
TYSGSP
Knoxville McGhee Tyson
Fri 12/4
6:02 pm-11:25 pm
1 stop5h 23m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$180
KnoxvilleGreenville
TYS Knoxville McGhee Tyson - GSP Greenville
TYSGSP
Knoxville McGhee Tyson
Sat 11/21
5:32 pm-9:32 am
2 stops16h 00m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$186
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Tue 12/1
4:32 pm-2:05 pm
2 stops21h 33m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$187
KnoxvilleCharleston
TYS Knoxville McGhee Tyson - CHS Charleston
TYSCHS
Knoxville McGhee Tyson
Tue 3/23
6:55 am-4:00 pm
2 stops9h 05m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$204
KnoxvilleGreenville
TYS Knoxville McGhee Tyson - GSP Greenville
TYSGSP
Knoxville McGhee Tyson
Fri 12/4
11:00 am-9:32 am
2 stops46h 32m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$205
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Fri 11/20
7:00 am-11:44 am
2 stops28h 44m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$214
Showing 1-10 of 46 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
TYS-GSP
TYS-CHS
TYS-MYR
TYS-HHH
TYS-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South Carolina
TYS-USSC
TYS-GSP
TYS-CHS
TYS-MYR
TYS-HHH
What is the cheapest month to book a flight from Knoxville to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $321). Flying from Knoxville to South Carolina in January is currently the most expensive (average of $601). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 10, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Food
7.2
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Food
7.2
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to South Carolina
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Complete your trip
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Knoxville and South Carolina flights
Browse other Knoxville and South Carolina flight options. Last updated on November 10, 2026.
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Knoxville to South Carolina flights
Consider these flights traveling from Knoxville to South Carolina.
Top 2 airlines flying from Knoxville to South Carolina
Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$236 | Average$367 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$273 | Average$475 | FlexibilityNo cancel fee | On-time71% |