$129+ Cheap flights from Knoxville (TYS) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Oct 26 — Nov 21
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to South CarolinaExplore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 26, 2026.
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:28 pm -
2 stops22h 16m
Fri 10/303:09 pm -
1 stop26h 19m
Deal found 9/25![Multiple Airlines logo]()
$270
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:40 am -
1 stop4h 27m
Wed 10/286:58 pm -
1 stop3h 24m
Deal found 9/23![Delta logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 pm -
1 stop14h 03m
Mon 11/21:53 pm -
1 stop27h 21m
Deal found 9/25![Multiple Airlines logo]()
$277
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:25 pm -
2 stops14h 40m
Wed 11/43:25 pm -
1 stop5h 25m
Deal found 9/24![Southwest logo]()
$284
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/203:46 pm -
1 stop5h 24m
Tue 10/273:33 pm -
1 stop3h 10m
Deal found 9/22![American Airlines logo]()
$287
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:40 am -
1 stop4h 21m
Tue 11/1012:12 pm -
1 stop3h 03m
Deal found 9/21![Delta logo]()
$287
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:13 am -
1 stop3h 19m
Thu 11/195:10 am -
1 stop3h 39m
Deal found 9/24![American Airlines logo]()
$301
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:40 am -
1 stop4h 27m
Fri 11/136:00 am -
1 stop5h 28m
Deal found 9/23![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:15 am -
1 stop6h 15m
Wed 10/281:35 pm -
2 stops7h 30m
Deal found 9/23![Southwest logo]()
$313
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:55 am -
1 stop10h 30m
Sat 1/98:10 am -
2 stops9h 30m
Deal found 9/23![Southwest logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:05 am -
1 stop22h 58m
Thu 10/292:46 pm -
1 stop21h 28m
Deal found 9/24![Multiple Airlines logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/99:35 pm -
1 stop11h 38m
Tue 10/134:03 pm -
1 stop18h 02m
Deal found 9/22![Multiple Airlines logo]()
$327
Best flights from Knoxville to South CarolinaDiscover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 26, 2026.
Discover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:28 pm -
2 stops22h 16m
Fri 10/303:09 pm -
1 stop26h 19m
Deal found 9/25![Multiple Airlines logo]()
$270
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:40 am -
1 stop4h 30m
Tue 10/275:30 am -
1 stop5h 24m
Deal found 9/22![Delta logo]()
$287
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:15 am -
1 stop6h 15m
Wed 10/281:35 pm -
2 stops7h 30m
Deal found 9/23![Southwest logo]()
$313
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:14 pm -
1 stop3h 15m
Thu 11/58:35 pm -
1 stop3h 23m
Deal found 9/26![American Airlines logo]()
$410
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:40 am -
1 stop4h 21m
Tue 11/1012:12 pm -
1 stop3h 03m
Deal found 9/21![Delta logo]()
$287
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/610:16 am -
1 stop8h 33m
Wed 2/1010:12 am -
1 stop13h 53m
Deal found 9/25![United Airlines logo]()
$675
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:20 am -
1 stop5h 15m
Tue 10/276:40 am -
2 stops10h 00m
Deal found 9/22![Southwest logo]()
$352
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:04 pm -
2 stops25h 40m
Tue 11/1011:28 am -
1 stop26h 17m
Deal found 9/21![Multiple Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/134:00 pm -
1 stop4h 13m
Sun 11/155:20 am -
1 stop4h 35m
Deal found 9/26![Delta logo]()
$338
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:15 am -
2 stops13h 10m
Tue 10/276:40 am -
2 stops10h 00m
Deal found 9/22![Southwest logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:36 pm -
1 stop14h 02m
Sun 11/157:00 am -
2 stops13h 43m
Deal found 9/26![Multiple Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:58 pm -
1 stop3h 23m
Mon 10/268:33 pm -
1 stop3h 22m
Deal found 9/21![American Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:00 am -
1 stop26h 38m
Tue 10/131:21 pm -
2 stops20h 44m
Deal found 9/24![Multiple Airlines logo]()
$381
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:23 pm -
1 stop4h 28m
Sun 10/255:40 am -
1 stop5h 14m
Deal found 9/22![Delta logo]()
$413
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:15 am -
2 stops14h 15m
Mon 11/28:20 am -
2 stops12h 10m
Deal found 9/25![Southwest logo]()
$415
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:56 am -
1 stop4h 17m
Wed 10/148:01 pm -
1 stop3h 54m
Deal found 9/25![American Airlines logo]()
$467
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:23 pm -
1 stop3h 00m
Sun 10/1811:28 am -
1 stop3h 28m
Deal found 9/24![Delta logo]()
$417
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:28 pm -
2 stops22h 16m
Sun 10/253:18 pm -
1 stop4h 22m
Deal found 9/21![Multiple Airlines logo]()
$417
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:25 pm -
2 stops14h 35m
Sat 10/246:15 am -
2 stops13h 25m
Deal found 9/25![Southwest logo]()
$418
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:56 am -
1 stop4h 09m
Wed 10/146:08 pm -
1 stop3h 41m
Deal found 9/25![American Airlines logo]()
$477
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:40 am -
2 stops13h 05m
Mon 10/194:45 pm -
2 stops6h 00m
Deal found 9/25![Southwest logo]()
$438
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/114:49 pm -
1 stop5h 13m
Sat 10/178:12 pm -
1 stop3h 43m
Deal found 9/24![American Airlines logo]()
$507
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:40 am -
1 stop4h 27m
Wed 10/1410:52 am -
1 stop4h 34m
Deal found 9/26![Delta logo]()
$467
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/99:35 pm -
1 stop11h 38m
Sun 10/112:46 pm -
1 stop20h 28m
Deal found 9/21![Multiple Airlines logo]()
$494
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:25 am -
2 stops15h 40m
Sat 10/1711:40 am -
1 stop8h 00m
Deal found 9/22![Southwest logo]()
$455
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:45 pm -
1 stop4h 14m
Thu 10/155:30 am -
1 stop4h 04m
Deal found 9/26![Delta logo]()
$467
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:25 pm -
2 stops21h 38m
Sun 10/256:20 am -
1 stop14h 34m
Deal found 9/22![United Airlines logo]()
$821
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:40 am -
1 stop3h 43m
Sun 10/117:14 pm -
1 stop2h 54m
Deal found 9/22![Delta logo]()
$467
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:40 am -
2 stops13h 05m
Sat 10/176:15 am -
2 stops13h 25m
Deal found 9/24![Southwest logo]()
$475
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:56 am -
1 stop4h 09m
Tue 10/132:13 pm -
1 stop3h 23m
Deal found 9/22![American Airlines logo]()
$589
Last-minute flights from Knoxville to South CarolinaDiscover last-minute flight deals from Knoxville to South Carolina. Data last updated September 26, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South Carolina. Data last updated September 26, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/99:35 pm -
1 stop11h 38m
Tue 10/134:03 pm -
1 stop18h 02m
Deal found 9/22![Multiple Airlines logo]()
$327
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/203:46 pm -
1 stop5h 24m
Tue 10/273:33 pm -
1 stop3h 10m
Deal found 9/22![American Airlines logo]()
$287
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:40 am -
1 stop4h 27m
Wed 10/286:58 pm -
1 stop3h 24m
Deal found 9/23![Delta logo]()
$273
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:15 am -
1 stop6h 15m
Wed 10/281:35 pm -
2 stops7h 30m
Deal found 9/23![Southwest logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:14 pm -
1 stop23h 57m
Tue 10/273:00 pm -
2 stops44h 29m
Deal found 9/22![Multiple Airlines logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:05 am -
1 stop22h 58m
Thu 10/292:46 pm -
1 stop21h 28m
Deal found 9/24![Multiple Airlines logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:33 pm -
1 stop15h 15m
Sat 10/246:00 am -
1 stop10h 48m
Deal found 9/25![Multiple Airlines logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:28 pm -
2 stops22h 16m
Fri 10/303:09 pm -
1 stop26h 19m
Deal found 9/25![Multiple Airlines logo]()
$270
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:40 am -
1 stop5h 50m
Thu 10/291:25 pm -
1 stop8h 10m
Deal found 9/23![Southwest logo]()
$341
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/284:14 pm -
1 stop22h 49m
Sun 11/82:46 pm -
1 stop22h 45m
Deal found 9/23![Multiple Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 pm -
1 stop14h 03m
Mon 11/21:53 pm -
1 stop27h 21m
Deal found 9/25![Multiple Airlines logo]()
$277
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:40 am -
1 stop4h 27m
Fri 11/136:00 am -
1 stop5h 28m
Deal found 9/23![Delta logo]()
$309
One-way flights from Knoxville to South CarolinaSearch for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 26, 2026.
Search for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:28 pm -
1 stop11h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$129
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:45 pm -
1 stop3h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Delta logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:00 am -
1 stop7h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Allegiant Air logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:05 am -
1 stop22h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$152
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:58 pm -
1 stop3h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![American Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/199:54 pm -
1 stop13h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$157
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:01 pm -
1 stop5h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![American Airlines logo]()
$165
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:45 am -
1 stop6h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Southwest logo]()
$172
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:10 am -
2 stops12h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Southwest logo]()
$176
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:40 am -
2 stops10h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Southwest logo]()
$177
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:40 am -
2 stops12h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Southwest logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
2 stops18h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Multiple Airlines logo]()
$191
Find flight deals from Knoxville to South Carolina
Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated September 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $270 (Kiwi.com) |
One-way from | $129 (Kiwi.com) |
Popular in | October |
Cheapest in | September |
Average price | $318 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 26, 2026.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Fri 10/23
9:28 pm-9:13 am
1 stop11h 45m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$129
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Tue 12/1
6:17 pm-10:47 pm
1 stop4h 30m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$137
KnoxvilleGreenville
TYS Knoxville McGhee Tyson - GSP Greenville
TYSGSP
Knoxville McGhee Tyson
Mon 11/2
7:25 pm-10:55 pm
1 stop3h 30m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$144
Quickest round-trip
KnoxvilleGreenville
TYS Knoxville McGhee Tyson - GSP Greenville
TYSGSP
Knoxville McGhee Tyson
Mon 10/26
7:45 pm-10:51 pm
1 stop3h 06m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$144
KnoxvilleGreenville
TYS Knoxville McGhee Tyson - GSP Greenville
TYSGSP
Knoxville McGhee Tyson
Sun 11/1
7:00 am-2:28 pm
1 stop7h 28m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$153
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Sat 10/17
7:58 pm-11:47 pm
1 stop3h 49m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Sat 11/14
7:10 am-7:35 pm
2 stops12h 25m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$176
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Sat 10/17
6:40 am-7:35 pm
2 stops12h 55m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$183
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Tue 10/6
6:04 pm-9:13 am
1 stop15h 09m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$184
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Fri 11/20
7:05 am-6:55 pm
2 stops11h 50m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$195
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
TYS-MYR
TYS-GSP
TYS-CHS
TYS-CAE
TYS-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South Carolina
TYS-USSC
TYS-MYR
TYS-GSP
TYS-CHS
TYS-CAE
What is the cheapest month to book a flight from Knoxville to South Carolina?
Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $336). Flying from Knoxville to South Carolina in January is currently the most expensive (average of $601). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to South Carolina?
Airfare is below average for this route at the moment.
Knoxville to South Carolina flights typically cost between $362 and $911 in October.The cheapest round-trip price found within the last 5 days was $287 on American Airlines (Oct 20-Oct 27).
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 26, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Overall
7.8
Boarding
8.1
Food
7.2
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Crew
8.5
Overall
7.8
Boarding
8.1
Food
7.2
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Crew
8.5
Overall
7.8
Boarding
8.1
Food
7.2
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Knoxville to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to South Carolina by cabin class
Find flights from Knoxville to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and South Carolina flights
Browse other Knoxville and South Carolina flight options. Last updated on September 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to South Carolina flights
Consider these flights traveling from Knoxville to South Carolina.
Top 2 airlines flying from Knoxville to South Carolina
Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$236 | Average$379 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$273 | Average$499 | FlexibilityNo cancel fee | On-time71% |