$98+ Cheap flights from Knoxville (TYS) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Jul 23 — Jul 301
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to South Carolina with Cheapflights
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Cheapest flights from Knoxville to South CarolinaExplore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 23, 2026.
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/151:05 pm
TYS
- CLT
1 stop8h 02m
Multiple Airlines
Wed 7/226:41 pm
CLT
- TYS
1 stop20h 07m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1511:16 am
TYS
- SAV
1 stop6h 39m
Multiple Airlines
Sat 8/2212:19 pm
SAV
- TYS
1 stop21h 45m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$220
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/512:56 pm
TYS
- SAV
1 stop24h 59m
Multiple Airlines
Thu 8/1310:05 am
SAV
- TYS
1 stop22h 31m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:05 pm
TYS
- SAV
1 stop24h 50m
Multiple Airlines
Wed 7/2912:19 pm
SAV
- TYS
1 stop26h 29m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:05 pm
TYS
- CLT
1 stop8h 02m
Multiple Airlines
Tue 7/286:41 pm
CLT
- TYS
1 stop23h 18m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$242
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:16 pm
TYS
- CLT
1 stop25h 33m
American Airlines
Sat 8/110:40 pm
CLT
- TYS
Nonstop1h 11m
American Airlines
Deal found 6/21![American Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/267:15 am
TYS
- SAV
1 stop6h 40m
Multiple Airlines
Thu 7/301:52 pm
SAV
- TYS
1 stop26h 50m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:15 am
TYS
- CLT
1 stop13h 52m
Multiple Airlines
Sat 7/186:41 pm
CLT
- TYS
1 stop17h 28m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:05 pm
TYS
- CHS
1 stop23h 59m
Multiple Airlines
Wed 7/298:56 pm
CHS
- TYS
2 stops39h 50m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:05 pm
TYS
- SAV
1 stop24h 50m
Multiple Airlines
Mon 7/2710:56 am
SAV
- TYS
2 stops11h 04m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:15 am
TYS
- SAV
1 stop6h 40m
Multiple Airlines
Sun 7/267:16 pm
SAV
- TYS
1 stop21h 26m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$264
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/188:05 pm
TYS
- MYR
1 stop3h 46m
American Airlines
Sat 7/258:44 pm
MYR
- TYS
1 stop3h 07m
American Airlines
Deal found 6/20![American Airlines logo]()
$265
Best flights from Knoxville to South CarolinaDiscover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 23, 2026.
Discover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/151:05 pm
TYS
- CLT
1 stop8h 02m
Multiple Airlines
Wed 7/226:41 pm
CLT
- TYS
1 stop20h 07m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$209
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:05 pm
TYS
- CHS
1 stop3h 43m
American Airlines
Wed 7/291:00 pm
CHS
- TYS
1 stop4h 37m
American Airlines
Deal found 6/22![American Airlines logo]()
$265
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:10 am
TYS
- CLT
1 stop5h 30m
Southwest
Wed 7/2210:40 am
CLT
- TYS
2 stops9h 45m
Southwest
Deal found 6/18![Southwest logo]()
$270
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:12 pm
TYS
- MYR
1 stop5h 18m
Delta
Thu 8/137:02 pm
MYR
- TYS
1 stop4h 50m
Delta
Deal found 6/19![Delta logo]()
$281
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:00 am
TYS
- SAV
2 stops12h 15m
Southwest
Sat 9/191:10 pm
SAV
- TYS
1 stop6h 10m
Southwest
Deal found 6/21![Southwest logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/27:15 am
TYS
- CHS
1 stop5h 49m
Multiple Airlines
Thu 8/67:47 pm
CHS
- TYS
1 stop12h 49m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$283
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:10 am
TYS
- MYR
2 stops10h 25m
Southwest
Wed 9/232:25 pm
MYR
- TYS
1 stop5h 25m
Southwest
Deal found 6/19![Southwest logo]()
$278
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:02 pm
TYS
- HHH
1 stop20h 01m
United Airlines
Wed 8/192:48 pm
HHH
- TYS
1 stop26h 10m
United Airlines
Deal found 6/22![United Airlines logo]()
$657
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/74:22 pm
TYS
- SAV
1 stop5h 22m
American Airlines
Sun 8/97:35 pm
SAV
- TYS
1 stop4h 24m
American Airlines
Deal found 6/23![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:50 am
TYS
- SAV
2 stops12h 45m
Southwest
Mon 8/312:00 pm
SAV
- TYS
1 stop5h 55m
Southwest
Deal found 6/22![Southwest logo]()
$284
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:40 am
TYS
- SAV
1 stop3h 36m
Delta
Sun 9/66:00 am
SAV
- TYS
1 stop3h 44m
Delta
Deal found 6/22![Delta logo]()
$357
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:10 am
TYS
- MYR
2 stops12h 30m
Southwest
Sat 9/1211:45 am
MYR
- TYS
1 stop7h 35m
Southwest
Deal found 6/20![Southwest logo]()
$289
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1510:28 am
TYS
- HHH
1 stop5h 01m
Delta
Sun 7/1912:11 pm
HHH
- TYS
1 stop5h 05m
Delta
Deal found 6/22![Delta logo]()
$368
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:10 am
TYS
- CHS
2 stops13h 20m
Southwest
Tue 9/158:10 am
CHS
- TYS
2 stops10h 45m
Southwest
Deal found 6/21![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:30 am
TYS
- CAE
1 stop3h 55m
Delta
Sun 10/256:50 pm
CAE
- TYS
1 stop4h 56m
Delta
Deal found 6/22![Delta logo]()
$407
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:55 am
TYS
- HHH
1 stop4h 15m
American Airlines
Fri 7/312:50 pm
HHH
- TYS
1 stop4h 47m
American Airlines
Deal found 6/19![American Airlines logo]()
$450
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:10 am
TYS
- SAV
2 stops8h 25m
Southwest
Sun 9/207:15 am
SAV
- TYS
1 stop5h 10m
Southwest
Deal found 6/19![Southwest logo]()
$314
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/307:35 am
TYS
- MYR
2 stops10h 35m
Southwest
Mon 8/312:30 pm
MYR
- TYS
1 stop4h 05m
Southwest
Deal found 6/20![Southwest logo]()
$320
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:00 am
TYS
- HHH
1 stop6h 17m
American Airlines
Sun 7/194:55 pm
HHH
- TYS
1 stop5h 28m
American Airlines
Deal found 6/19![American Airlines logo]()
$473
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:40 am
TYS
- CAE
1 stop5h 34m
Delta
Thu 7/167:39 pm
CAE
- TYS
1 stop4h 13m
Delta
Deal found 6/21![Delta logo]()
$447
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/211:55 pm
TYS
- CLT
1 stop5h 45m
Southwest
Sat 11/286:05 am
CLT
- TYS
1 stop6h 10m
Southwest
Deal found 6/22![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:28 am
TYS
- CAE
1 stop4h 38m
Delta
Sun 7/125:35 am
CAE
- TYS
1 stop5h 35m
Delta
Deal found 6/22![Delta logo]()
$447
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3012:15 pm
TYS
- CLT
1 stop18h 11m
American Airlines
Fri 7/319:15 am
CLT
- TYS
Nonstop1h 23m
American Airlines
Deal found 6/20![American Airlines logo]()
$497
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:10 am
TYS
- MYR
2 stops10h 25m
Southwest
Mon 8/316:40 am
MYR
- TYS
2 stops11h 55m
Southwest
Deal found 6/19![Southwest logo]()
$325
This United Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:19 pm
TYS
- CAE
1 stop14h 37m
United Airlines
Thu 7/167:45 pm
CAE
- TYS
2 stops24h 59m
United Airlines
Deal found 6/21![United Airlines logo]()
$732
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:25 pm
TYS
- MYR
2 stops14h 35m
Southwest
Fri 11/2010:45 am
MYR
- TYS
1 stop9h 45m
Southwest
Deal found 6/23![Southwest logo]()
$325
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2711:01 am
TYS
- HHH
1 stop5h 33m
American Airlines
Mon 6/292:43 pm
HHH
- TYS
1 stop4h 50m
American Airlines
Deal found 6/18![American Airlines logo]()
$546
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1010:00 am
TYS
- CAE
1 stop9h 09m
United Airlines
Thu 7/167:45 pm
CAE
- TYS
2 stops24h 59m
United Airlines
Deal found 6/20![United Airlines logo]()
$732
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/197:05 am
TYS
- CLT
2 stops10h 15m
Southwest
Wed 7/226:50 am
CLT
- TYS
1 stop5h 15m
Southwest
Deal found 6/23![Southwest logo]()
$326
This United Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/127:35 pm
TYS
- CAE
1 stop18h 35m
United Airlines
Wed 12/166:30 am
CAE
- TYS
1 stop27h 29m
United Airlines
Deal found 6/21![United Airlines logo]()
$734
Last-minute flights from Knoxville to South CarolinaDiscover last-minute flight deals from Knoxville to South Carolina. Data last updated June 23, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South Carolina. Data last updated June 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/151:05 pm
TYS
- CLT
1 stop8h 02m
Multiple Airlines
Wed 7/226:41 pm
CLT
- TYS
1 stop20h 07m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:15 am
TYS
- CLT
1 stop13h 52m
Multiple Airlines
Sat 7/186:41 pm
CLT
- TYS
1 stop17h 28m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$251
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/188:05 pm
TYS
- MYR
1 stop3h 46m
American Airlines
Sat 7/258:44 pm
MYR
- TYS
1 stop3h 07m
American Airlines
Deal found 6/20![American Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:05 pm
TYS
- SAV
1 stop24h 50m
Multiple Airlines
Wed 7/2912:19 pm
SAV
- TYS
1 stop26h 29m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:05 pm
TYS
- CLT
1 stop8h 02m
Multiple Airlines
Tue 7/286:41 pm
CLT
- TYS
1 stop23h 18m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:05 pm
TYS
- CHS
1 stop23h 59m
Multiple Airlines
Wed 7/298:56 pm
CHS
- TYS
2 stops39h 50m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/221:05 pm
TYS
- SAV
1 stop24h 50m
Multiple Airlines
Mon 7/2710:56 am
SAV
- TYS
2 stops11h 04m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$262
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:05 pm
TYS
- CHS
1 stop3h 43m
American Airlines
Wed 7/291:00 pm
CHS
- TYS
1 stop4h 37m
American Airlines
Deal found 6/22![American Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:15 am
TYS
- SAV
1 stop6h 40m
Multiple Airlines
Sun 7/267:16 pm
SAV
- TYS
1 stop21h 26m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/267:15 am
TYS
- SAV
1 stop6h 40m
Multiple Airlines
Thu 7/301:52 pm
SAV
- TYS
1 stop26h 50m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/309:11 pm
TYS
- CLT
1 stop23h 56m
Multiple Airlines
Mon 8/312:24 pm
CLT
- TYS
1 stop11h 09m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$268
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:16 pm
TYS
- CLT
1 stop25h 33m
American Airlines
Sat 8/110:40 pm
CLT
- TYS
Nonstop1h 11m
American Airlines
Deal found 6/21![American Airlines logo]()
$247
One-way flights from Knoxville to South CarolinaSearch for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 23, 2026.
Search for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/169:11 pm
TYS
- CLT
1 stop23h 56m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/149:26 am
TYS
- CLT
1 stop11h 47m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/151:05 pm
TYS
- CLT
1 stop8h 02m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:49 pm
TYS
- CLT
1 stop28h 54m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:20 pm
TYS
- CHS
1 stop13h 18m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/179:26 am
TYS
- CLT
1 stop28h 54m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:20 am
TYS
- CHS
1 stop24h 18m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:52 pm
TYS
- CLT
1 stop27h 51m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1712:53 pm
TYS
- CLT
2 stops32h 14m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/169:11 pm
TYS
- MYR
1 stop12h 39m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$131
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/217:43 pm
TYS
- MYR
1 stop4h 12m
Delta
Deal found 6/20![Delta logo]()
$133
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:10 am
TYS
- SAV
1 stop5h 30m
Southwest
Deal found 6/18![Southwest logo]()
$133
Find flight deals from Knoxville to South Carolina
Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated June 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $209 (Kiwi.com) |
One-way from | $98 (Kiwi.com) |
Popular in | March |
Cheapest in | August |
Average price | $317 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 23, 2026.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleCharlotte
TYS - CLT
TYSCLT
Knoxville McGhee Tyson
Wed 7/15
1:05 pm-9:07 pm
1 stop8h 02m
Charlotte Douglas
Wed 7/22
6:41 pm-2:48 pm
1 stop20h 07m
$209
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Wed 7/22
8:05 pm-11:48 pm
1 stop3h 43m
Charleston
Wed 7/29
1:00 pm-5:37 pm
1 stop4h 37m
$265
KnoxvilleCharlotte
TYS - CLT
TYSCLT
Knoxville McGhee Tyson
Wed 7/15
7:10 am-12:40 pm
1 stop5h 30m
Charlotte Douglas
Wed 7/22
10:40 am-8:25 pm
2 stops9h 45m
$270
KnoxvilleSavannah
TYS - SAV
TYSSAV
Knoxville McGhee Tyson
Tue 9/15
7:00 am-7:15 pm
2 stops12h 15m
Savannah/Hilton Head
Sat 9/19
1:10 pm-7:20 pm
1 stop6h 10m
$276
KnoxvilleMyrtle Beach
TYS - MYR
TYSMYR
Knoxville McGhee Tyson
Mon 9/21
7:10 am-5:35 pm
2 stops10h 25m
Myrtle Beach Intl
Wed 9/23
2:25 pm-7:50 pm
1 stop5h 25m
$278
KnoxvilleMyrtle Beach
TYS - MYR
TYSMYR
Knoxville McGhee Tyson
Thu 8/6
6:12 pm-11:30 pm
1 stop5h 18m
Myrtle Beach Intl
Thu 8/13
7:02 pm-11:52 pm
1 stop4h 50m
$281
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Sun 8/2
7:15 am-1:04 pm
1 stop5h 49m
Charleston
Thu 8/6
7:47 pm-8:36 am
1 stop12h 49m
$283
KnoxvilleSavannah
TYS - SAV
TYSSAV
Knoxville McGhee Tyson
Sat 8/29
6:50 am-7:35 pm
2 stops12h 45m
Savannah/Hilton Head
Mon 8/31
2:00 pm-7:55 pm
1 stop5h 55m
$284
KnoxvilleMyrtle Beach
TYS - MYR
TYSMYR
Knoxville McGhee Tyson
Thu 9/10
7:10 am-7:40 pm
2 stops12h 30m
Myrtle Beach Intl
Sat 9/12
11:45 am-7:20 pm
1 stop7h 35m
$289
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Thu 9/10
7:10 am-8:30 pm
2 stops13h 20m
Charleston
Tue 9/15
8:10 am-6:55 pm
2 stops10h 45m
$297
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
TYS-CLT
TYS-CHS
TYS-MYR
TYS-SAV
TYS-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South Carolina
TYS-USSC
TYS-CLT
TYS-CHS
TYS-MYR
TYS-SAV
What is the cheapest month to book a flight from Knoxville to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $196). Flying from Knoxville to South Carolina in January is currently the most expensive (average of $527). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 23, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to South Carolina
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Complete your trip
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Knoxville and South Carolina flights
Browse other Knoxville and South Carolina flight options. Last updated on June 23, 2026.
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Knoxville to South Carolina flights
Consider these flights traveling from Knoxville to South Carolina.
Top 2 airlines flying from Knoxville to South Carolina
Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$431 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$238 | Average$475 | FlexibilityNo cancel fee | On-timeN/A |