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Knoxville

$131+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/4. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Jun 8 — Jun 151
Mon 6/8
Mon 6/15
1 adult, Economy
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Cheap flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 9, 2026.

This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:56 pm
CHS
-
TYS
1 stop25h 27m
Multiple Airlines
Tue 7/74:20 pm
TYS
-
CHS
1 stop17h 18m
Multiple Airlines
Deal found 5/4$273
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:30 pm
MYR
-
TYS
1 stop3h 41m
Delta
Wed 6/105:40 am
TYS
-
MYR
1 stop5h 04m
Delta
Deal found 5/4$279
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/53:23 pm
CHS
-
TYS
1 stop8h 16m
Multiple Airlines
Fri 6/127:30 am
TYS
-
CHS
2 stops31h 58m
Multiple Airlines
Deal found 5/6$290
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/13:00 pm
CHS
-
TYS
1 stop6h 15m
Southwest
Tue 7/78:10 am
TYS
-
CHS
2 stops12h 15m
Southwest
Deal found 5/4$292
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:45 pm
CLT
-
TYS
1 stop7h 05m
Southwest
Tue 6/96:55 pm
TYS
-
CLT
1 stop3h 10m
Southwest
Deal found 5/5$295
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:00 am
SAV
-
TYS
1 stop5h 38m
American Airlines
Tue 7/216:10 pm
TYS
-
SAV
1 stop4h 01m
American Airlines
Deal found 5/6$295
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/41:00 pm
CLT
-
TYS
1 stop7h 30m
Multiple Airlines
Mon 6/87:27 pm
TYS
-
CLT
2 stops26h 08m
Multiple Airlines
Deal found 5/8$297
This Southwest deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:55 pm
SAV
-
TYS
1 stop4h 45m
Southwest
Tue 10/207:00 am
TYS
-
SAV
1 stop5h 20m
Southwest
Deal found 5/6$297
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:00 pm
CLT
-
TYS
1 stop4h 40m
Southwest
Thu 9/245:45 pm
TYS
-
CLT
1 stop4h 05m
Southwest
Deal found 5/5$299
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:50 am
CLT
-
TYS
1 stop5h 15m
Southwest
Wed 7/297:10 am
TYS
-
CLT
2 stops8h 30m
Southwest
Deal found 5/7$300
This Southwest deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/302:10 pm
MYR
-
TYS
1 stop7h 05m
Southwest
Tue 7/78:10 am
TYS
-
MYR
1 stop10h 15m
Southwest
Deal found 5/6$300
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:18 pm
CHS
-
TYS
1 stop27h 58m
Multiple Airlines
Sat 6/135:56 pm
TYS
-
CHS
1 stop14h 42m
Multiple Airlines
Deal found 5/8$301

Find flight deals from South Carolina to Knoxville

Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated May 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$273
(Kiwi.com)

One-way from

$131
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$470
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
Search Deals
From South Carolina to Knoxville McGhee Tyson
Search Deals
One-way flight from South Carolina to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($80 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 9, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 6/3

1:30 pm-5:11 pm

1 stop3h 41m

Knoxville McGhee Tyson

Wed 6/10

5:40 am-10:44 am

1 stop5h 04m

$279

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 6/6

6:18 pm-10:16 pm

1 stop27h 58m

Knoxville McGhee Tyson

Sat 6/13

5:56 pm-8:38 am

1 stop14h 42m

$301

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 6/4

7:55 pm-11:56 pm

1 stop4h 01m

Knoxville McGhee Tyson

Thu 6/11

7:46 pm-11:59 pm

1 stop4h 13m

$318

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 6/6

3:50 pm-9:20 pm

1 stop5h 30m

Knoxville McGhee Tyson

Fri 6/12

7:30 am-6:35 pm

1 stop11h 05m

$323
Quickest round-trip

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 6/10

6:15 am-9:53 am

1 stop3h 38m

Knoxville McGhee Tyson

Thu 6/11

5:40 am-9:00 am

1 stop3h 20m

$326

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 6/10

3:00 pm-9:15 pm

1 stop6h 15m

Knoxville McGhee Tyson

Thu 6/11

7:30 am-9:35 pm

2 stops14h 05m

$327

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 6/5

4:00 pm-9:10 pm

1 stop5h 10m

Knoxville McGhee Tyson

Fri 6/12

6:40 am-12:35 pm

1 stop5h 55m

$337

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 6/13

1:05 pm-9:20 pm

1 stop8h 15m

Knoxville McGhee Tyson

Sun 6/14

7:00 pm-11:25 pm

1 stop4h 25m

$342

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 6/6

6:30 am-2:05 pm

2 stops7h 35m

Knoxville McGhee Tyson

Sat 6/13

6:55 pm-10:10 am

2 stops15h 15m

$345

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 10/16

6:45 am-12:15 pm

1 stop5h 30m

Knoxville McGhee Tyson

Sun 10/18

6:25 am-12:30 pm

1 stop6h 05m

$347

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/5

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Knoxville

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $228). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $556). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from South Carolina to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from South Carolina to Knoxville?

    For as low as $279, Delta can have you in Knoxville from South Carolina in 3h 41m. The distance from South Carolina to Knoxville is about 323 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Charleston - Knoxville McGhee Tyson, Charlotte Douglas - Knoxville McGhee Tyson or Savannah/Hilton Head - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $228). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $556). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

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Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$254Average$498FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$283Average$336FlexibilityNo cancel feeOn-time71%

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