$140+ Cheap flights from South Carolina to Knoxville (TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Dec 9 — Dec 161
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to KnoxvilleExplore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 9, 2026.
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/74:57 pm -
1 stop20h 10m
Mon 12/149:00 am -
1 stop23h 38m
Deal found 11/9![Multiple Airlines logo]()
$272
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:01 pm -
1 stop4h 13m
Sat 12/125:40 am -
1 stop3h 50m
Deal found 11/5![Delta logo]()
$287
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/32:07 pm -
1 stop4h 23m
Mon 12/77:26 pm -
1 stop2h 56m
Deal found 11/5![Delta logo]()
$287
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:34 pm -
1 stop3h 25m
Thu 12/108:00 pm -
1 stop3h 58m
Deal found 11/5![American Airlines logo]()
$290
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:40 am -
2 stops13h 05m
Sat 12/127:10 am -
1 stop6h 05m
Deal found 11/5![Southwest logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:10 pm -
1 stop12h 17m
Thu 12/1011:00 am -
2 stops21h 03m
Deal found 11/5![Multiple Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:11 pm -
1 stop3h 15m
Sun 12/136:50 am -
1 stop3h 40m
Deal found 11/6![American Airlines logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/194:10 pm -
2 stops25h 33m
Wed 12/236:12 pm -
1 stop14h 26m
Deal found 11/6![Multiple Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/193:20 pm -
1 stop6h 20m
Wed 12/237:15 pm -
1 stop5h 00m
Deal found 11/6![Southwest logo]()
$363
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:35 am -
1 stop5h 45m
Sun 12/137:25 pm -
2 stops14h 55m
Deal found 11/6![Southwest logo]()
$364
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/218:02 pm -
1 stop3h 51m
Mon 12/288:01 pm -
1 stop3h 58m
Deal found 11/6![American Airlines logo]()
$368
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/171:40 pm -
1 stop8h 05m
Sun 12/207:15 pm -
2 stops14h 45m
Deal found 11/9![Southwest logo]()
$377
Best flights from South Carolina to KnoxvilleDiscover carefully curated flight deals from South Carolina to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 9, 2026.
Discover carefully curated flight deals from South Carolina to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 9, 2026.
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:01 pm -
1 stop4h 13m
Sat 12/125:40 am -
1 stop3h 50m
Deal found 11/5![Delta logo]()
$287
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/218:02 pm -
1 stop3h 51m
Mon 12/288:01 pm -
1 stop3h 58m
Deal found 11/6![American Airlines logo]()
$368
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:00 am -
2 stops11h 50m
Sun 12/137:25 pm -
2 stops14h 55m
Deal found 11/6![Southwest logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:07 pm -
1 stop25h 07m
Tue 11/249:51 pm -
1 stop15h 52m
Deal found 11/5![Allegiant Air logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/232:42 pm -
2 stops31h 24m
Fri 11/275:33 pm -
1 stop14h 21m
Deal found 11/8![Multiple Airlines logo]()
$480
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/32:07 pm -
1 stop4h 23m
Mon 12/77:26 pm -
1 stop2h 56m
Deal found 11/5![Delta logo]()
$287
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/316:20 am -
1 stop5h 35m
Mon 2/16:45 am -
2 stops8h 35m
Deal found 11/9![Southwest logo]()
$373
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/216:29 pm -
3 stops20h 18m
Mon 1/255:55 pm -
2 stops23h 53m
Deal found 11/5![United Airlines logo]()
$769
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:07 pm -
1 stop18h 10m
Sun 11/229:49 pm -
1 stop15h 54m
Deal found 11/5![Allegiant Air logo]()
$392
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:40 am -
2 stops13h 05m
Sat 12/127:10 am -
2 stops12h 55m
Deal found 11/5![Southwest logo]()
$374
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/171:40 pm -
1 stop8h 05m
Sun 12/207:15 pm -
2 stops14h 45m
Deal found 11/9![Southwest logo]()
$377
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:09 am -
1 stop3h 40m
Sat 11/288:04 pm -
1 stop3h 50m
Deal found 11/9![American Airlines logo]()
$473
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/232:00 pm -
1 stop4h 49m
Fri 11/277:00 am -
1 stop3h 47m
Deal found 11/8![Delta logo]()
$497
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:44 pm -
1 stop3h 15m
Fri 11/276:50 am -
1 stop3h 30m
Deal found 11/9![American Airlines logo]()
$497
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:20 am -
1 stop6h 08m
Wed 11/256:10 pm -
1 stop3h 03m
Deal found 11/5![Delta logo]()
$497
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:47 pm -
1 stop3h 54m
Fri 11/276:50 am -
1 stop3h 46m
Deal found 11/8![American Airlines logo]()
$507
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/243:51 pm -
1 stop7h 32m
Sat 11/286:44 pm -
2 stops37h 29m
Deal found 11/9![Multiple Airlines logo]()
$629
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/184:55 pm -
1 stop4h 50m
Sat 12/267:45 pm -
1 stop4h 30m
Deal found 11/8![Southwest logo]()
$483
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:05 pm -
1 stop4h 17m
Thu 11/264:00 pm -
1 stop4h 10m
Deal found 11/7![Delta logo]()
$507
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:07 am -
1 stop6h 28m
Sat 11/288:04 pm -
1 stop3h 27m
Deal found 11/9![American Airlines logo]()
$527
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/214:55 pm -
1 stop4h 50m
Sun 12/277:15 pm -
1 stop5h 00m
Deal found 11/6![Southwest logo]()
$512
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/232:00 pm -
1 stop4h 49m
Sat 11/285:40 am -
1 stop4h 07m
Deal found 11/8![Delta logo]()
$547
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/221:40 pm -
1 stop8h 05m
Thu 11/266:45 am -
1 stop6h 15m
Deal found 11/7![Southwest logo]()
$521
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/232:51 pm -
2 stops19h 02m
Sat 11/285:45 am -
1 stop13h 16m
Deal found 11/7![United Airlines logo]()
$866
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:55 am -
2 stops11h 05m
Wed 11/257:15 pm -
2 stops15h 00m
Deal found 11/5![Southwest logo]()
$532
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:44 pm -
1 stop3h 15m
Sat 11/2111:01 am -
1 stop4h 40m
Deal found 11/7![American Airlines logo]()
$653
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:54 pm -
1 stop18h 54m
Wed 11/255:45 am -
1 stop13h 23m
Deal found 11/6![United Airlines logo]()
$887
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/241:59 pm -
1 stop3h 23m
Sat 11/285:40 am -
1 stop3h 45m
Deal found 11/9![Delta logo]()
$607
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:54 pm -
1 stop23h 42m
Fri 11/275:45 am -
1 stop13h 23m
Deal found 11/8![United Airlines logo]()
$887
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:53 am -
1 stop3h 40m
Thu 11/2611:28 am -
2 stops24h 49m
Deal found 11/7![American Airlines logo]()
$796
Last-minute flights from South Carolina to KnoxvilleDiscover last-minute flight deals from South Carolina to Knoxville. Data last updated November 9, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Knoxville. Data last updated November 9, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/32:07 pm -
1 stop4h 23m
Mon 12/77:26 pm -
1 stop2h 56m
Deal found 11/5![Delta logo]()
$287
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:34 pm -
1 stop3h 25m
Thu 12/108:00 pm -
1 stop3h 58m
Deal found 11/5![American Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:10 pm -
1 stop12h 17m
Thu 12/1011:00 am -
2 stops21h 03m
Deal found 11/5![Multiple Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:01 pm -
1 stop4h 13m
Sat 12/125:40 am -
1 stop3h 50m
Deal found 11/5![Delta logo]()
$287
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:40 am -
2 stops13h 05m
Sat 12/127:10 am -
1 stop6h 05m
Deal found 11/5![Southwest logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/74:57 pm -
1 stop20h 10m
Mon 12/149:00 am -
1 stop23h 38m
Deal found 11/9![Multiple Airlines logo]()
$272
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:11 pm -
1 stop3h 15m
Sun 12/136:50 am -
1 stop3h 40m
Deal found 11/6![American Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:35 am -
1 stop5h 45m
Sun 12/137:25 pm -
2 stops14h 55m
Deal found 11/6![Southwest logo]()
$364
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/171:40 pm -
1 stop8h 05m
Sun 12/207:15 pm -
2 stops14h 45m
Deal found 11/9![Southwest logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/194:10 pm -
2 stops25h 33m
Wed 12/236:12 pm -
1 stop14h 26m
Deal found 11/6![Multiple Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/193:20 pm -
1 stop6h 20m
Wed 12/237:15 pm -
1 stop5h 00m
Deal found 11/6![Southwest logo]()
$363
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/218:02 pm -
1 stop3h 51m
Mon 12/288:01 pm -
1 stop3h 58m
Deal found 11/6![American Airlines logo]()
$368
One-way flights from South Carolina to KnoxvilleSearch for one-way flight options from South Carolina to Knoxville. Find affordable one-way fares based on user searches. Data last updated November 9, 2026.
Search for one-way flight options from South Carolina to Knoxville. Find affordable one-way fares based on user searches. Data last updated November 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:21 pm -
2 stops26h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![Multiple Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:03 pm -
1 stop20h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Multiple Airlines logo]()
$140
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/114:00 pm -
1 stop5h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Southwest logo]()
$154
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:30 pm -
1 stop7h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![Southwest logo]()
$155
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1511:00 am -
2 stops9h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Southwest logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/118:58 pm -
2 stops13h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Multiple Airlines logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/244:50 pm -
2 stops23h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$220
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:58 pm -
1 stop13h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![Multiple Airlines logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:42 pm -
2 stops44h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$236
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:10 am -
2 stops11h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Southwest logo]()
$355
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/283:30 pm -
1 stop4h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![American Airlines logo]()
$398
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:21 pm -
1 stop3h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![American Airlines logo]()
$418
Find flight deals from South Carolina to Knoxville
Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated November 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $272 (Kiwi.com) |
One-way from | $140 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 9, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Tue 12/1
1:21 pm-4:19 pm
2 stops26h 58m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$140
Myrtle BeachKnoxville
MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson
MYRTYS
Myrtle Beach Intl
Tue 11/17
4:03 pm-12:06 pm
1 stop20h 03m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$140
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Fri 12/11
4:00 pm-9:45 pm
1 stop5h 45m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$154
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Tue 12/1
1:30 pm-8:50 pm
1 stop7h 20m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Tue 12/15
11:00 am-8:50 pm
2 stops9h 50m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$160
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Wed 11/18
3:42 pm-12:11 pm
2 stops44h 29m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$236
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Tue 12/15
3:00 pm-1:00 pm
3 stops46h 00m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$273
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Sat 12/5
4:01 pm-8:14 pm
1 stop4h 13m
Knoxville McGhee Tyson
Sat 12/12
5:40 am-9:30 am
1 stop3h 50m
$287
GreenvilleKnoxville
GSP Greenville - TYS Knoxville McGhee Tyson
GSPTYS
Greenville
Thu 12/3
2:07 pm-6:30 pm
1 stop4h 23m
Knoxville McGhee Tyson
Mon 12/7
7:26 pm-10:22 pm
1 stop2h 56m
$287
Myrtle BeachKnoxville
MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson
MYRTYS
Myrtle Beach Intl
Tue 11/17
8:10 am-7:50 pm
2 stops11h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$355
Showing 1-10 of 49 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
CHS-TYS
MYR-TYS
CAE-TYS
FLO-TYS
GSP-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Knoxville
USSC-TYS
CHS-TYS
MYR-TYS
CAE-TYS
FLO-TYS
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Newport
Bryson City
Crossville
Morristown
Murphy
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Alternative routes for South Carolina to Knoxville
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 9, 2026.
South Carolina and Knoxville flights
Browse other South Carolina and Knoxville flight options. Last updated on November 9, 2026.
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South Carolina to Knoxville flights
Consider these flights traveling from South Carolina to Knoxville.
Top 2 airlines flying from South Carolina to Knoxville
Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$254 | Average$511 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$317 | Average$435 | FlexibilityNo cancel fee | On-time71% |