$98+ Cheap flights from South Carolina to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/22. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Jul 24 — Jul 311
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Knoxville with Cheapflights
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Cheapest flights from South Carolina to KnoxvilleExplore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 24, 2026.
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:41 pm
CLT
- TYS
1 stop13h 51m
Multiple Airlines
Sun 8/27:15 am
TYS
- CLT
1 stop13h 52m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/231:52 pm
SAV
- TYS
1 stop26h 50m
Multiple Airlines
Thu 7/309:11 pm
TYS
- SAV
2 stops47h 08m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/203:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Mon 7/277:20 pm
TYS
- CHS
1 stop13h 18m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2912:19 pm
SAV
- TYS
1 stop26h 29m
Multiple Airlines
Wed 8/512:56 pm
TYS
- SAV
1 stop24h 59m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:41 pm
CLT
- TYS
1 stop13h 55m
Multiple Airlines
Mon 8/106:29 pm
TYS
- CLT
2 stops23h 17m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/173:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Fri 7/247:20 pm
TYS
- CHS
1 stop13h 28m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$259
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/257:50 pm
CHS
- TYS
1 stop4h 01m
American Airlines
Tue 7/2810:00 am
TYS
- CHS
1 stop4h 41m
American Airlines
Deal found 6/20![American Airlines logo]()
$265
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:50 am
CLT
- TYS
1 stop5h 15m
Southwest
Wed 7/298:10 am
TYS
- CLT
1 stop6h 25m
Southwest
Deal found 6/23![Southwest logo]()
$265
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:10 pm
MYR
- TYS
1 stop5h 41m
American Airlines
Tue 7/286:10 pm
TYS
- MYR
1 stop3h 33m
American Airlines
Deal found 6/21![American Airlines logo]()
$265
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:00 am
SAV
- TYS
1 stop5h 38m
American Airlines
Wed 7/2910:00 am
TYS
- SAV
1 stop4h 27m
American Airlines
Deal found 6/24![American Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/243:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Tue 7/2811:31 am
TYS
- CHS
1 stop27h 57m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$267
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:30 am
CHS
- TYS
2 stops7h 35m
Southwest
Tue 7/287:10 am
TYS
- CHS
1 stop6h 00m
Southwest
Deal found 6/20![Southwest logo]()
$270
Best flights from South Carolina to KnoxvilleDiscover carefully curated flight deals from South Carolina to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 24, 2026.
Discover carefully curated flight deals from South Carolina to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/173:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Fri 7/247:20 pm
TYS
- CHS
1 stop13h 28m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$259
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:50 am
CLT
- TYS
1 stop5h 15m
Southwest
Wed 7/298:10 am
TYS
- CLT
1 stop6h 25m
Southwest
Deal found 6/23![Southwest logo]()
$265
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:10 pm
MYR
- TYS
1 stop5h 41m
American Airlines
Tue 7/286:10 pm
TYS
- MYR
1 stop3h 33m
American Airlines
Deal found 6/20![American Airlines logo]()
$265
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1511:42 am
MYR
- TYS
1 stop3h 06m
Delta
Wed 7/157:43 pm
TYS
- MYR
1 stop4h 12m
Delta
Deal found 6/23![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:45 am
SAV
- TYS
1 stop5h 20m
Southwest
Sat 9/56:50 am
TYS
- SAV
1 stop5h 40m
Southwest
Deal found 6/21![Southwest logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/101:13 pm
MYR
- TYS
1 stop9h 31m
Multiple Airlines
Thu 8/138:29 pm
TYS
- MYR
1 stop13h 21m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$280
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:30 am
CHS
- TYS
2 stops7h 35m
Southwest
Tue 7/287:10 am
TYS
- CHS
1 stop6h 00m
Southwest
Deal found 6/20![Southwest logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/63:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Fri 7/107:20 pm
TYS
- CHS
1 stop13h 28m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$282
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/291:25 pm
SAV
- TYS
2 stops7h 00m
Southwest
Wed 8/57:00 am
TYS
- SAV
1 stop5h 30m
Southwest
Deal found 6/21![Southwest logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/101:13 pm
MYR
- TYS
1 stop10h 20m
Multiple Airlines
Thu 7/169:11 pm
TYS
- MYR
1 stop12h 39m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$282
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:45 am
CLT
- TYS
1 stop5h 30m
Southwest
Sat 12/57:10 am
TYS
- CLT
1 stop5h 50m
Southwest
Deal found 6/23![Southwest logo]()
$273
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/22:48 pm
HHH
- TYS
1 stop26h 10m
United Airlines
Sat 9/56:02 pm
TYS
- HHH
1 stop20h 01m
United Airlines
Deal found 6/23![United Airlines logo]()
$757
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:50 pm
CHS
- TYS
1 stop4h 01m
American Airlines
Thu 7/168:05 pm
TYS
- CHS
1 stop3h 54m
American Airlines
Deal found 6/21![American Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:45 pm
CHS
- TYS
1 stop5h 07m
Delta
Mon 9/75:40 am
TYS
- CHS
1 stop4h 28m
Delta
Deal found 6/22![Delta logo]()
$415
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:40 am
MYR
- TYS
2 stops11h 55m
Southwest
Thu 8/138:25 am
TYS
- MYR
1 stop5h 25m
Southwest
Deal found 6/21![Southwest logo]()
$292
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2411:47 am
HHH
- TYS
1 stop5h 50m
American Airlines
Tue 7/2811:03 am
TYS
- HHH
1 stop3h 13m
American Airlines
Deal found 6/24![American Airlines logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:53 pm
MYR
- TYS
1 stop26h 06m
Multiple Airlines
Sat 7/118:40 pm
TYS
- MYR
1 stop21h 05m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:45 am
SAV
- TYS
1 stop5h 20m
Southwest
Sun 8/307:35 am
TYS
- SAV
1 stop5h 40m
Southwest
Deal found 6/22![Southwest logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/112:19 pm
SAV
- TYS
1 stop7h 31m
Multiple Airlines
Mon 8/36:30 am
TYS
- SAV
2 stops15h 57m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$356
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/193:25 pm
MYR
- TYS
1 stop4h 25m
Southwest
Mon 11/237:05 am
TYS
- MYR
1 stop5h 55m
Southwest
Deal found 6/24![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1912:11 pm
HHH
- TYS
1 stop5h 05m
Delta
Tue 7/2110:26 am
TYS
- HHH
1 stop5h 03m
Delta
Deal found 6/20![Delta logo]()
$527
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:50 am
SAV
- TYS
1 stop5h 10m
Southwest
Fri 8/75:45 pm
TYS
- SAV
1 stop4h 10m
Southwest
Deal found 6/22![Southwest logo]()
$309
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:10 am
MYR
- TYS
2 stops10h 25m
Southwest
Sat 8/156:50 am
TYS
- MYR
1 stop5h 55m
Southwest
Deal found 6/23![Southwest logo]()
$312
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:15 am
CHS
- TYS
1 stop3h 23m
Delta
Sun 7/55:40 am
TYS
- CHS
1 stop3h 20m
Delta
Deal found 6/22![Delta logo]()
$567
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/204:55 pm
HHH
- TYS
1 stop5h 28m
American Airlines
Mon 7/278:05 pm
TYS
- HHH
2 stops14h 32m
American Airlines
Deal found 6/20![American Airlines logo]()
$581
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/202:00 pm
MYR
- TYS
2 stops7h 15m
Southwest
Tue 7/218:10 am
TYS
- MYR
1 stop10h 15m
Southwest
Deal found 6/20![Southwest logo]()
$312
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/711:47 am
HHH
- TYS
1 stop3h 55m
American Airlines
Sat 7/1111:03 am
TYS
- HHH
1 stop6h 05m
American Airlines
Deal found 6/22![American Airlines logo]()
$591
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:30 am
MYR
- TYS
2 stops11h 55m
Southwest
Tue 7/287:10 am
TYS
- MYR
2 stops11h 15m
Southwest
Deal found 6/21![Southwest logo]()
$322
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:30 am
CLT
- TYS
1 stop5h 35m
Southwest
Tue 7/146:55 pm
TYS
- CLT
1 stop3h 15m
Southwest
Deal found 6/21![Southwest logo]()
$337
This United Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/63:05 pm
HHH
- TYS
1 stop18h 38m
United Airlines
Fri 7/107:19 pm
TYS
- HHH
2 stops19h 02m
United Airlines
Deal found 6/21![United Airlines logo]()
$997
Last-minute flights from South Carolina to KnoxvilleDiscover last-minute flight deals from South Carolina to Knoxville. Data last updated June 24, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Knoxville. Data last updated June 24, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/173:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Fri 7/247:20 pm
TYS
- CHS
1 stop13h 28m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/203:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Mon 7/277:20 pm
TYS
- CHS
1 stop13h 18m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$249
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:10 pm
MYR
- TYS
1 stop5h 41m
American Airlines
Tue 7/286:10 pm
TYS
- MYR
1 stop3h 33m
American Airlines
Deal found 6/21![American Airlines logo]()
$265
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:00 am
SAV
- TYS
1 stop5h 38m
American Airlines
Wed 7/2910:00 am
TYS
- SAV
1 stop4h 27m
American Airlines
Deal found 6/23![American Airlines logo]()
$265
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:50 am
CLT
- TYS
1 stop5h 15m
Southwest
Wed 7/298:10 am
TYS
- CLT
1 stop6h 25m
Southwest
Deal found 6/23![Southwest logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/231:52 pm
SAV
- TYS
1 stop26h 50m
Multiple Airlines
Thu 7/309:11 pm
TYS
- SAV
2 stops47h 08m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/243:23 pm
CHS
- TYS
1 stop8h 10m
Multiple Airlines
Tue 7/2811:31 am
TYS
- CHS
1 stop27h 57m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$267
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/257:50 pm
CHS
- TYS
1 stop4h 01m
American Airlines
Tue 7/2810:00 am
TYS
- CHS
1 stop4h 41m
American Airlines
Deal found 6/20![American Airlines logo]()
$265
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:30 am
CHS
- TYS
2 stops7h 35m
Southwest
Tue 7/287:10 am
TYS
- CHS
1 stop6h 00m
Southwest
Deal found 6/20![Southwest logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2912:19 pm
SAV
- TYS
1 stop26h 29m
Multiple Airlines
Wed 8/512:56 pm
TYS
- SAV
1 stop24h 59m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$253
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/291:25 pm
SAV
- TYS
2 stops7h 00m
Southwest
Wed 8/57:00 am
TYS
- SAV
1 stop5h 30m
Southwest
Deal found 6/21![Southwest logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:41 pm
CLT
- TYS
1 stop13h 51m
Multiple Airlines
Sun 8/27:15 am
TYS
- CLT
1 stop13h 52m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$236
One-way flights from South Carolina to KnoxvilleSearch for one-way flight options from South Carolina to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 24, 2026.
Search for one-way flight options from South Carolina to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/229:46 am
CLT
- TYS
1 stop24h 18m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:46 am
CLT
- TYS
1 stop24h 18m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:41 pm
CLT
- TYS
1 stop21h 32m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/199:46 am
CLT
- TYS
1 stop24h 18m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:56 pm
CHS
- TYS
1 stop13h 49m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:41 pm
CLT
- TYS
1 stop21h 29m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:38 pm
CLT
- TYS
1 stop23h 12m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:38 pm
CLT
- TYS
1 stop16h 36m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/219:46 am
CLT
- TYS
1 stop8h 18m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:41 pm
CLT
- TYS
1 stop23h 18m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$127
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/151:51 pm
MYR
- TYS
1 stop3h 25m
Delta
Deal found 6/23![Delta logo]()
$133
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:00 am
SAV
- TYS
1 stop6h 37m
American Airlines
Deal found 6/20![American Airlines logo]()
$133
Find flight deals from South Carolina to Knoxville
Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated June 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $236 (Kiwi.com) |
One-way from | $98 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $386 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 24, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Fri 7/17
3:23 pm-11:33 pm
1 stop8h 10m
Knoxville McGhee Tyson
Fri 7/24
7:20 pm-8:48 am
1 stop13h 28m
$259
CharlotteKnoxville
CLT - TYS
CLTTYS
Charlotte Douglas
Wed 7/22
6:50 am-12:05 pm
1 stop5h 15m
Knoxville McGhee Tyson
Wed 7/29
8:10 am-2:35 pm
1 stop6h 25m
$265
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Tue 7/21
6:10 pm-11:51 pm
1 stop5h 41m
Knoxville McGhee Tyson
Tue 7/28
6:10 pm-9:43 pm
1 stop3h 33m
$265
SavannahKnoxville
SAV - TYS
SAVTYS
Savannah/Hilton Head
Tue 9/1
6:45 am-12:05 pm
1 stop5h 20m
Knoxville McGhee Tyson
Sat 9/5
6:50 am-12:30 pm
1 stop5h 40m
$265
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Sat 7/25
6:30 am-2:05 pm
2 stops7h 35m
Knoxville McGhee Tyson
Tue 7/28
7:10 am-1:10 pm
1 stop6h 00m
$270
SavannahKnoxville
SAV - TYS
SAVTYS
Savannah/Hilton Head
Wed 7/29
1:25 pm-8:25 pm
2 stops7h 00m
Knoxville McGhee Tyson
Wed 8/5
7:00 am-12:30 pm
1 stop5h 30m
$270
CharlotteKnoxville
CLT - TYS
CLTTYS
Charlotte Douglas
Tue 12/1
6:45 am-12:15 pm
1 stop5h 30m
Knoxville McGhee Tyson
Sat 12/5
7:10 am-1:00 pm
1 stop5h 50m
$273
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Mon 8/10
1:13 pm-10:44 pm
1 stop9h 31m
Knoxville McGhee Tyson
Thu 8/13
8:29 pm-9:50 am
1 stop13h 21m
$280
CharlestonKnoxville
CHS - TYS
CHSTYS
Charleston
Mon 7/6
3:23 pm-11:33 pm
1 stop8h 10m
Knoxville McGhee Tyson
Fri 7/10
7:20 pm-8:48 am
1 stop13h 28m
$282
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Fri 7/10
1:13 pm-11:33 pm
1 stop10h 20m
Knoxville McGhee Tyson
Thu 7/16
9:11 pm-9:50 am
1 stop12h 39m
$282
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
CLT-TYS
CHS-TYS
MYR-TYS
SAV-TYS
HHH-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Knoxville
USSC-TYS
CLT-TYS
CHS-TYS
MYR-TYS
SAV-TYS
What is the cheapest month to book a flight from South Carolina to Knoxville?
Currently, September is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $228). Flying from South Carolina to Knoxville in April is currently the most expensive (average of $578). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to Knoxville
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Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Knoxville by cabin class
Find flights from South Carolina to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 24, 2026.
South Carolina and Knoxville flights
Browse other South Carolina and Knoxville flight options. Last updated on June 24, 2026.
Popular flight searches
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South Carolina to Knoxville flights
Consider these flights traveling from South Carolina to Knoxville.
Top 2 airlines flying from South Carolina to Knoxville
Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$254 | Average$498 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$283 | Average$316 | FlexibilityNo cancel fee | On-time71% |