$102+ Cheap flights from South Carolina to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Sep 10 — Sep 171
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Knoxville with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to KnoxvilleExplore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:20 am -
1 stop3h 24m
Wed 9/166:15 am -
1 stop3h 32m
Deal found 8/10![American Airlines logo]()
$227
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:50 am -
1 stop5h 30m
Sun 9/66:10 pm -
1 stop3h 25m
Deal found 8/10![Southwest logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/249:44 pm -
1 stop11h 56m
Wed 8/2610:54 am -
1 stop21h 44m
Deal found 8/8![Multiple Airlines logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:46 am -
1 stop24h 18m
Mon 8/312:49 pm -
1 stop17h 12m
Deal found 8/10![Multiple Airlines logo]()
$236
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:00 am -
2 stops10h 55m
Sun 9/66:10 pm -
1 stop3h 25m
Deal found 8/10![Southwest logo]()
$236
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/87:48 pm -
1 stop3h 10m
Tue 9/156:15 am -
1 stop3h 32m
Deal found 8/11![American Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/289:46 am -
1 stop27h 18m
Mon 8/312:49 pm -
1 stop17h 12m
Deal found 8/10![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:57 pm -
1 stop17h 17m
Mon 9/217:04 pm -
1 stop17h 27m
Deal found 8/8![Multiple Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:02 pm -
1 stop14h 12m
Sun 10/256:00 am -
1 stop7h 47m
Deal found 8/6![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:05 am -
1 stop6h 02m
Wed 9/910:54 am -
1 stop5h 21m
Deal found 8/6![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:46 am -
1 stop24h 18m
Mon 8/312:49 pm -
1 stop17h 12m
Deal found 8/10![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/139:40 pm -
1 stop22h 59m
Sat 9/196:55 pm -
1 stop25h 00m
Deal found 8/9![Multiple Airlines logo]()
$267
Best flights from South Carolina to KnoxvilleDiscover carefully curated flight deals from South Carolina to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
Discover carefully curated flight deals from South Carolina to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:30 am -
1 stop5h 24m
Wed 10/146:23 pm -
1 stop5h 34m
Deal found 8/8![Delta logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/241:13 pm -
1 stop5h 52m
Thu 8/274:52 pm -
1 stop16h 58m
Deal found 8/10![Multiple Airlines logo]()
$292
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:45 am -
2 stops13h 10m
Wed 9/168:05 am -
1 stop4h 30m
Deal found 8/10![Southwest logo]()
$299
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:15 am -
1 stop3h 28m
Wed 9/97:30 am -
1 stop3h 50m
Deal found 8/9![American Airlines logo]()
$367
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:50 am -
1 stop14h 09m
Wed 10/289:45 am -
1 stop9h 45m
Deal found 8/10![United Airlines logo]()
$494
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/232:58 pm -
1 stop26h 39m
Sat 8/296:56 pm -
2 stops20h 18m
Deal found 8/10![Multiple Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/88:10 am -
2 stops10h 50m
Tue 9/158:05 am -
1 stop4h 30m
Deal found 8/11![Southwest logo]()
$328
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:25 am -
1 stop4h 04m
Tue 10/65:40 am -
1 stop3h 12m
Deal found 8/9![Delta logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:14 pm -
1 stop15h 01m
Sun 10/119:20 am -
1 stop11h 39m
Deal found 8/6![Multiple Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:45 pm -
2 stops5h 55m
Sat 10/242:55 pm -
1 stop3h 45m
Deal found 8/6![Southwest logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:56 am -
1 stop8h 25m
Mon 9/78:30 am -
1 stop23h 31m
Deal found 8/6![Multiple Airlines logo]()
$348
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:40 am -
2 stops10h 55m
Wed 9/97:00 am -
2 stops10h 40m
Deal found 8/6![Southwest logo]()
$349
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/308:11 pm -
1 stop3h 41m
Wed 9/24:38 pm -
1 stop5h 04m
Deal found 8/8![Delta logo]()
$387
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:48 pm -
1 stop3h 10m
Mon 9/75:15 am -
1 stop4h 24m
Deal found 8/8![American Airlines logo]()
$453
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:45 am -
1 stop5h 20m
Thu 9/37:10 am -
2 stops13h 40m
Deal found 8/6![Southwest logo]()
$358
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:18 pm -
1 stop4h 24m
Sun 11/86:23 pm -
1 stop5h 36m
Deal found 8/7![Delta logo]()
$400
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:50 am -
2 stops9h 10m
Wed 9/167:00 am -
2 stops6h 50m
Deal found 8/11![Southwest logo]()
$377
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:23 am -
2 stops23h 30m
Sat 10/315:45 am -
1 stop8h 43m
Deal found 8/10![United Airlines logo]()
$566
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:16 pm -
1 stop3h 43m
Tue 8/2512:09 pm -
1 stop4h 29m
Deal found 8/11![American Airlines logo]()
$522
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:45 pm -
1 stop5h 07m
Sun 8/304:38 pm -
1 stop4h 06m
Deal found 8/10![Delta logo]()
$447
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/199:40 pm -
Nonstop1h 10m
Sat 9/262:00 pm -
Nonstop1h 23m
Deal found 8/6![American Airlines logo]()
$525
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/221:40 pm -
1 stop8h 00m
Fri 11/277:25 pm -
2 stops14h 10m
Deal found 8/11![Southwest logo]()
$403
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:17 pm -
1 stop3h 02m
Sun 8/305:40 am -
1 stop3h 18m
Deal found 8/10![Delta logo]()
$447
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1210:25 am -
2 stops12h 24m
Mon 9/145:45 am -
1 stop18h 14m
Deal found 8/6![United Airlines logo]()
$626
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:30 pm -
1 stop4h 05m
Tue 9/87:00 am -
2 stops6h 50m
Deal found 8/11![Southwest logo]()
$408
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:15 pm -
1 stop3h 51m
Fri 9/256:06 pm -
2 stops16h 31m
Deal found 8/10![American Airlines logo]()
$561
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:55 pm -
1 stop14h 42m
Wed 9/96:00 pm -
2 stops20h 18m
Deal found 8/6![United Airlines logo]()
$628
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:10 am -
1 stop4h 26m
Mon 9/75:40 am -
1 stop4h 28m
Deal found 8/7![Delta logo]()
$492
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:15 pm -
1 stop5h 35m
Mon 9/148:15 pm -
2 stops16h 00m
Deal found 8/11![American Airlines logo]()
$573
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:05 pm -
1 stop7h 05m
Tue 9/295:30 pm -
1 stop4h 00m
Deal found 8/8![Southwest logo]()
$447
Last-minute flights from South Carolina to KnoxvilleDiscover last-minute flight deals from South Carolina to Knoxville. Data last updated August 11, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Knoxville. Data last updated August 11, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/249:44 pm -
1 stop11h 56m
Wed 8/2610:54 am -
1 stop21h 44m
Deal found 8/8![Multiple Airlines logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:46 am -
1 stop24h 18m
Mon 8/312:49 pm -
1 stop17h 12m
Deal found 8/10![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/289:46 am -
1 stop27h 18m
Mon 8/312:49 pm -
1 stop17h 12m
Deal found 8/10![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:46 am -
1 stop24h 18m
Mon 8/312:49 pm -
1 stop17h 12m
Deal found 8/10![Multiple Airlines logo]()
$236
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:50 am -
1 stop5h 30m
Sun 9/66:10 pm -
1 stop3h 25m
Deal found 8/10![Southwest logo]()
$231
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:00 am -
2 stops10h 55m
Sun 9/66:10 pm -
1 stop3h 25m
Deal found 8/10![Southwest logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:05 am -
1 stop6h 02m
Wed 9/910:54 am -
1 stop5h 21m
Deal found 8/6![Multiple Airlines logo]()
$251
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/87:48 pm -
1 stop3h 10m
Tue 9/156:15 am -
1 stop3h 32m
Deal found 8/11![American Airlines logo]()
$239
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:20 am -
1 stop3h 24m
Wed 9/166:15 am -
1 stop3h 32m
Deal found 8/10![American Airlines logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:59 am -
1 stop22h 05m
Wed 9/1610:54 am -
2 stops25h 20m
Deal found 8/11![Multiple Airlines logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/139:40 pm -
1 stop22h 59m
Sat 9/196:55 pm -
1 stop25h 00m
Deal found 8/9![Multiple Airlines logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:57 pm -
1 stop17h 17m
Mon 9/217:04 pm -
1 stop17h 27m
Deal found 8/8![Multiple Airlines logo]()
$243
One-way flights from South Carolina to KnoxvilleSearch for one-way flight options from South Carolina to Knoxville. Find affordable one-way fares based on user searches. Data last updated August 11, 2026.
Search for one-way flight options from South Carolina to Knoxville. Find affordable one-way fares based on user searches. Data last updated August 11, 2026.
This Mytrip deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/610:07 am -
1 stop9h 29m
Deal found 8/7![Avelo Airlines logo]()
$102
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/61:00 pm -
1 stop4h 35m
Deal found 8/11![American Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:05 am -
1 stop5h 57m
Deal found 8/6![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:46 am -
1 stop24h 18m
Deal found 8/7![Multiple Airlines logo]()
$110
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/68:10 am -
1 stop3h 58m
Deal found 8/10![American Airlines logo]()
$114
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:30 pm -
1 stop6h 25m
Deal found 8/9![Southwest logo]()
$114
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:12 pm -
1 stop3h 43m
Deal found 8/11![American Airlines logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:14 pm -
1 stop6h 07m
Deal found 8/6![Multiple Airlines logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:53 pm -
1 stop28h 12m
Deal found 8/6![Multiple Airlines logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/89:46 am -
1 stop24h 18m
Deal found 8/8![Multiple Airlines logo]()
$118
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:25 am -
1 stop6h 25m
Deal found 8/9![Southwest logo]()
$122
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:33 pm -
1 stop5h 22m
Deal found 8/8![American Airlines logo]()
$124
Find flight deals from South Carolina to Knoxville
Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated August 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $227 (American Airlines) |
One-way from | $102 (Mytrip) |
Popular in | March |
Cheapest in | September |
Average price | $329 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SavannahKnoxville
SAV Savannah/Hilton Head - TYS Knoxville McGhee Tyson
SAVTYS
Savannah/Hilton Head
Wed 10/14
5:30 am-10:54 am
1 stop5h 24m
Knoxville McGhee Tyson
Wed 10/14
6:23 pm-11:57 pm
1 stop5h 34m
$269
Myrtle BeachKnoxville
MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson
MYRTYS
Myrtle Beach Intl
Mon 8/24
1:13 pm-7:05 pm
1 stop5h 52m
Knoxville McGhee Tyson
Thu 8/27
4:52 pm-9:50 am
1 stop16h 58m
$292
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Wed 9/9
6:45 am-7:55 pm
2 stops13h 10m
Knoxville McGhee Tyson
Wed 9/16
8:05 am-12:35 pm
1 stop4h 30m
$299
Myrtle BeachKnoxville
MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson
MYRTYS
Myrtle Beach Intl
Sun 8/23
2:58 pm-5:37 pm
1 stop26h 39m
Knoxville McGhee Tyson
Sat 8/29
6:56 pm-3:14 pm
2 stops20h 18m
$310
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Tue 9/8
8:10 am-7:00 pm
2 stops10h 50m
Knoxville McGhee Tyson
Tue 9/15
8:05 am-12:35 pm
1 stop4h 30m
$328
SavannahKnoxville
SAV Savannah/Hilton Head - TYS Knoxville McGhee Tyson
SAVTYS
Savannah/Hilton Head
Thu 10/8
5:14 pm-8:15 am
1 stop15h 01m
Knoxville McGhee Tyson
Sun 10/11
9:20 am-8:59 pm
1 stop11h 39m
$341
CharlotteKnoxville
CLT Charlotte Douglas - TYS Knoxville McGhee Tyson
CLTTYS
Charlotte Douglas
Thu 9/3
8:56 am-5:21 pm
1 stop8h 25m
Knoxville McGhee Tyson
Mon 9/7
8:30 am-8:01 am
1 stop23h 31m
$348
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Mon 10/19
4:45 pm-10:40 pm
2 stops5h 55m
Knoxville McGhee Tyson
Sat 10/24
2:55 pm-6:40 pm
1 stop3h 45m
$349
SavannahKnoxville
SAV Savannah/Hilton Head - TYS Knoxville McGhee Tyson
SAVTYS
Savannah/Hilton Head
Thu 9/3
7:40 am-6:35 pm
2 stops10h 55m
Knoxville McGhee Tyson
Wed 9/9
7:00 am-5:40 pm
2 stops10h 40m
$349
SavannahKnoxville
SAV Savannah/Hilton Head - TYS Knoxville McGhee Tyson
SAVTYS
Savannah/Hilton Head
Tue 8/25
6:45 am-12:05 pm
1 stop5h 20m
Knoxville McGhee Tyson
Thu 9/3
7:10 am-8:50 pm
2 stops13h 40m
$358
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
CHS-TYS
SAV-TYS
CLT-TYS
MYR-TYS
HHH-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Knoxville
USSC-TYS
CHS-TYS
SAV-TYS
CLT-TYS
MYR-TYS
What is the cheapest month to book a flight from South Carolina to Knoxville?
Currently, October is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $316). Flying from South Carolina to Knoxville in August is currently the most expensive (average of $637). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to Knoxville
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Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Knoxville by cabin class
Find flights from South Carolina to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 11, 2026.
South Carolina and Knoxville flights
Browse other South Carolina and Knoxville flight options. Last updated on August 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Knoxville flights
Consider these flights traveling from South Carolina to Knoxville.
Top 2 airlines flying from South Carolina to Knoxville
Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$254 | Average$508 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$283 | Average$316 | FlexibilityNo cancel fee | On-time71% |