$127+ Cheap flights from South Carolina to Knoxville (TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Oct 26 — Nov 21
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Knoxville
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Cheapest flights from South Carolina to KnoxvilleExplore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 26, 2026.
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 26, 2026.
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/212:02 pm -
1 stop4h 46m
Sat 12/54:12 pm -
1 stop4h 53m
Deal found 9/22![American Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:43 pm -
1 stop6h 50m
Tue 11/36:04 pm -
2 stops25h 40m
Deal found 9/22![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/264:57 pm -
1 stop24h 17m
Mon 11/27:00 am -
1 stop25h 38m
Deal found 9/26![Multiple Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:43 pm -
1 stop6h 50m
Sun 11/17:00 am -
1 stop7h 28m
Deal found 9/22![Allegiant Air logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 am -
1 stop24h 24m
Tue 11/36:04 pm -
2 stops25h 40m
Deal found 9/22![Multiple Airlines logo]()
$291
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:44 pm -
1 stop3h 15m
Fri 11/276:50 am -
1 stop3h 30m
Deal found 9/21![American Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:20 am -
1 stop4h 35m
Fri 11/134:00 pm -
1 stop6h 04m
Deal found 9/26![Delta logo]()
$298
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:10 pm -
1 stop7h 25m
Mon 11/27:25 pm -
1 stop3h 30m
Deal found 9/22![Southwest logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:09 pm -
1 stop5h 42m
Sun 11/17:00 am -
1 stop7h 28m
Deal found 9/24![Allegiant Air logo]()
$304
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:35 am -
1 stop5h 45m
Fri 11/137:25 pm -
2 stops14h 40m
Deal found 9/26![Southwest logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:52 pm -
2 stops13h 13m
Sun 11/17:00 am -
1 stop7h 28m
Deal found 9/22![Multiple Airlines logo]()
$310
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:52 am -
1 stop4h 34m
Wed 10/285:40 am -
1 stop4h 27m
Deal found 9/21![Delta logo]()
$310
Best flights from South Carolina to KnoxvilleDiscover carefully curated flight deals from South Carolina to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 26, 2026.
Discover carefully curated flight deals from South Carolina to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 26, 2026.
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:44 pm -
1 stop3h 15m
Fri 11/276:50 am -
1 stop3h 30m
Deal found 9/21![American Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:52 pm -
2 stops13h 13m
Sun 11/17:00 am -
1 stop7h 28m
Deal found 9/24![Multiple Airlines logo]()
$313
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:05 pm -
1 stop4h 54m
Fri 10/237:45 pm -
1 stop3h 06m
Deal found 9/21![Delta logo]()
$314
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:10 pm -
1 stop7h 25m
Mon 11/27:25 pm -
1 stop3h 30m
Deal found 9/24![Southwest logo]()
$328
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:30 pm -
1 stop5h 22m
Wed 10/141:51 pm -
1 stop18h 18m
Deal found 9/25![Allegiant Air logo]()
$440
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:12 am -
2 stops12h 12m
Sun 11/17:00 am -
1 stop7h 28m
Deal found 9/22![Multiple Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:10 pm -
1 stop6h 00m
Wed 10/287:15 am -
2 stops9h 00m
Deal found 9/21![Southwest logo]()
$363
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:08 am -
1 stop5h 18m
Tue 11/37:09 am -
1 stop2h 52m
Deal found 9/22![Delta logo]()
$373
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 am -
1 stop24h 24m
Mon 11/28:15 am -
2 stops11h 57m
Deal found 9/24![Multiple Airlines logo]()
$352
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:43 pm -
2 stops21h 16m
Mon 11/25:40 pm -
2 stops16h 11m
Deal found 9/24![United Airlines logo]()
$805
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:40 am -
1 stop3h 54m
Tue 11/37:09 am -
1 stop2h 52m
Deal found 9/22![Delta logo]()
$383
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/118:20 am -
2 stops12h 10m
Sat 12/197:45 pm -
2 stops14h 15m
Deal found 9/21![Southwest logo]()
$409
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:12 pm -
2 stops15h 53m
Mon 10/268:14 pm -
1 stop13h 41m
Deal found 9/25![Multiple Airlines logo]()
$372
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:28 am -
1 stop6h 00m
Sun 11/15:40 am -
1 stop3h 50m
Deal found 9/26![Delta logo]()
$397
This KAYAK deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2912:22 pm -
1 stop5h 09m
Wed 9/308:18 am -
1 stop3h 34m
Deal found 9/25![American Airlines logo]()
$556
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2112:45 pm -
1 stop8h 55m
Mon 11/237:05 am -
2 stops11h 50m
Deal found 9/26![Southwest logo]()
$468
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:30 am -
1 stop3h 04m
Sun 10/255:40 am -
1 stop4h 30m
Deal found 9/21![Delta logo]()
$432
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:13 pm -
1 stop10h 02m
Mon 10/56:30 am -
1 stop26h 08m
Deal found 9/22![Multiple Airlines logo]()
$451
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:09 am -
1 stop3h 23m
Tue 10/136:06 pm -
1 stop5h 06m
Deal found 9/24![American Airlines logo]()
$582
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:10 pm -
1 stop6h 00m
Sun 10/116:25 am -
2 stops15h 40m
Deal found 9/23![Southwest logo]()
$493
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:35 pm -
1 stop4h 47m
Thu 10/157:45 pm -
1 stop3h 06m
Deal found 9/26![Delta logo]()
$467
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/192:33 pm -
1 stop4h 59m
Wed 10/213:41 pm -
1 stop6h 10m
Deal found 9/22![American Airlines logo]()
$605
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:40 am -
2 stops13h 30m
Thu 10/157:15 am -
2 stops14h 30m
Deal found 9/26![Southwest logo]()
$508
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:57 pm -
1 stop15h 38m
Tue 10/137:04 pm -
2 stops18h 20m
Deal found 9/23![Multiple Airlines logo]()
$523
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/71:59 pm -
1 stop6h 09m
Tue 10/132:38 pm -
1 stop5h 32m
Deal found 9/24![Delta logo]()
$487
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:38 am -
2 stops13h 21m
Wed 10/289:45 am -
3 stops24h 36m
Deal found 9/21![United Airlines logo]()
$809
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:09 am -
1 stop3h 23m
Mon 10/128:57 am -
1 stop5h 12m
Deal found 9/23![American Airlines logo]()
$627
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/88:59 am -
1 stop14h 37m
Mon 10/129:33 pm -
1 stop19h 46m
Deal found 9/23![Multiple Airlines logo]()
$526
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:40 am -
2 stops10h 00m
Sun 10/116:25 am -
2 stops13h 55m
Deal found 9/22![Southwest logo]()
$533
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:00 pm -
2 stops18h 17m
Mon 10/267:35 pm -
3 stops14h 46m
Deal found 9/25![United Airlines logo]()
$825
Last-minute flights from South Carolina to KnoxvilleDiscover last-minute flight deals from South Carolina to Knoxville. Data last updated September 26, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Knoxville. Data last updated September 26, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:21 pm -
2 stops20h 44m
Thu 10/156:15 am -
1 stop9h 56m
Deal found 9/26![Multiple Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:52 am -
1 stop4h 34m
Wed 10/285:40 am -
1 stop4h 27m
Deal found 9/21![Delta logo]()
$310
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:30 am -
1 stop4h 04m
Fri 10/237:45 pm -
1 stop4h 14m
Deal found 9/24![Delta logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/264:57 pm -
1 stop24h 17m
Mon 11/27:00 am -
1 stop25h 38m
Deal found 9/26![Multiple Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:43 pm -
1 stop6h 50m
Tue 11/36:04 pm -
2 stops25h 40m
Deal found 9/22![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:43 pm -
1 stop6h 50m
Sun 11/17:00 am -
1 stop7h 28m
Deal found 9/22![Allegiant Air logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:43 pm -
1 stop6h 50m
Mon 11/28:14 pm -
2 stops19h 15m
Deal found 9/22![Multiple Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:12 am -
2 stops12h 12m
Sun 11/17:00 am -
1 stop7h 28m
Deal found 9/22![Multiple Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 am -
1 stop24h 24m
Tue 11/36:04 pm -
2 stops25h 40m
Deal found 9/22![Multiple Airlines logo]()
$291
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:10 pm -
1 stop7h 25m
Mon 11/27:25 pm -
1 stop3h 30m
Deal found 9/22![Southwest logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:09 pm -
1 stop5h 42m
Sun 11/17:00 am -
1 stop7h 28m
Deal found 9/24![Allegiant Air logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:52 pm -
2 stops13h 13m
Sun 11/17:00 am -
1 stop7h 28m
Deal found 9/22![Multiple Airlines logo]()
$310
One-way flights from South Carolina to KnoxvilleSearch for one-way flight options from South Carolina to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 26, 2026.
Search for one-way flight options from South Carolina to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:09 pm -
1 stop26h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Allegiant Air logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/74:57 pm -
1 stop20h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Multiple Airlines logo]()
$136
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:51 pm -
1 stop5h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Delta logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:52 pm -
2 stops13h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$149
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:14 pm -
1 stop4h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Delta logo]()
$154
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:30 am -
1 stop5h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Delta logo]()
$155
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1410:35 am -
1 stop7h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Southwest logo]()
$160
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:10 am -
1 stop3h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![American Airlines logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:12 pm -
2 stops23h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:58 pm -
2 stops13h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:21 pm -
2 stops20h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Multiple Airlines logo]()
$177
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:13 pm -
1 stop10h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$195
Find flight deals from South Carolina to Knoxville
Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated September 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $273 (American Airlines) |
One-way from | $127 (Kiwi.com) |
Popular in | February |
Cheapest in | January |
Average price | $508 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 26, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleKnoxville
GSP Greenville - TYS Knoxville McGhee Tyson
GSPTYS
Greenville
Fri 10/30
3:09 pm-5:28 pm
1 stop26h 19m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$127
Myrtle BeachKnoxville
MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson
MYRTYS
Myrtle Beach Intl
Mon 11/16
6:51 pm-11:59 pm
1 stop5h 08m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$137
GreenvilleKnoxville
GSP Greenville - TYS Knoxville McGhee Tyson
GSPTYS
Greenville
Fri 10/30
8:52 pm-10:05 am
2 stops13h 13m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$149
GreenvilleKnoxville
GSP Greenville - TYS Knoxville McGhee Tyson
GSPTYS
Greenville
Fri 10/16
7:14 pm-11:59 pm
1 stop4h 45m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$154
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Mon 12/7
8:58 pm-1:07 pm
2 stops16h 09m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Fri 10/30
5:30 am-10:54 am
1 stop5h 24m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
Myrtle BeachKnoxville
MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson
MYRTYS
Myrtle Beach Intl
Sat 11/14
10:35 am-5:45 pm
1 stop7h 10m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$160
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Thu 10/15
7:50 am-1:40 pm
1 stop5h 50m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$163
Myrtle BeachKnoxville
MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson
MYRTYS
Myrtle Beach Intl
Thu 11/19
5:10 am-8:49 am
1 stop3h 39m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$165
CharlestonKnoxville
CHS Charleston - TYS Knoxville McGhee Tyson
CHSTYS
Charleston
Tue 10/13
1:21 pm-10:05 am
2 stops20h 44m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$177
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
MYR-TYS
GSP-TYS
CHS-TYS
CAE-TYS
FLO-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Knoxville
USSC-TYS
MYR-TYS
GSP-TYS
CHS-TYS
CAE-TYS
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 26, 2026.
South Carolina and Knoxville flights
Browse other South Carolina and Knoxville flight options. Last updated on September 26, 2026.
Popular flight searches
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South Carolina to Knoxville flights
Consider these flights traveling from South Carolina to Knoxville.
Top 2 airlines flying from South Carolina to Knoxville
Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$254 | Average$508 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$311 | Average$359 | FlexibilityNo cancel fee | On-time71% |