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$109+ Cheap flights from Myrtle Beach to Knoxville (MYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/27. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — TYS
May 27 — Jun 31
Wed 5/27
Wed 6/3
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Knoxville

Cheapest flights from Myrtle Beach to Knoxville
Explore the most affordable flight options available from Myrtle Beach to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 27, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
MYR
-
TYS
1 stop14h 50m
Multiple Airlines
Thu 5/149:40 pm
TYS
-
MYR
1 stop22h 56m
Multiple Airlines
Deal found 4/22$224
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:00 am
MYR
-
TYS
1 stop14h 50m
Multiple Airlines
Thu 5/149:40 pm
TYS
-
MYR
1 stop22h 56m
Multiple Airlines
Deal found 4/26$236
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:30 am
MYR
-
TYS
1 stop9h 51m
Multiple Airlines
Sat 5/3010:57 am
TYS
-
MYR
1 stop9h 39m
Multiple Airlines
Deal found 4/25$244
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:17 pm
MYR
-
TYS
1 stop23h 40m
Multiple Airlines
Wed 6/171:02 pm
TYS
-
MYR
1 stop7h 34m
Multiple Airlines
Deal found 4/26$273
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:28 pm
MYR
-
TYS
1 stop26h 20m
Multiple Airlines
Sat 6/277:10 am
TYS
-
MYR
1 stop7h 09m
Multiple Airlines
Deal found 4/22$276
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:00 am
MYR
-
TYS
1 stop14h 50m
Multiple Airlines
Fri 5/151:15 pm
TYS
-
MYR
1 stop19h 50m
Multiple Airlines
Deal found 4/22$277
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/277:00 am
MYR
-
TYS
1 stop4h 49m
Multiple Airlines
Tue 6/305:02 pm
TYS
-
MYR
1 stop27h 05m
Multiple Airlines
Deal found 4/22$280
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
MYR
-
TYS
1 stop14h 50m
Multiple Airlines
Sat 5/911:56 am
TYS
-
MYR
1 stop8h 40m
Multiple Airlines
Deal found 4/25$281
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:00 am
MYR
-
TYS
1 stop14h 50m
Multiple Airlines
Wed 5/201:01 pm
TYS
-
MYR
1 stop7h 35m
Multiple Airlines
Deal found 4/25$289

Find flight deals from Myrtle Beach to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$224
(Kiwi.com)

One-way from

$109
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$438
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
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From Myrtle Beach Intl to Knoxville McGhee Tyson
Search Deals
One-way flight from Myrtle Beach Intl to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($73 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 5/7

6:00 am-8:50 pm

1 stop14h 50m

Knoxville McGhee Tyson

Thu 5/14

9:40 pm-8:36 pm

1 stop22h 56m

$224

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 9/21

2:41 pm-8:39 pm

1 stop5h 58m

Knoxville McGhee Tyson

Thu 9/24

5:17 pm-7:58 am

1 stop14h 41m

$292

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 6/10

10:25 am-8:20 pm

1 stop9h 55m

Knoxville McGhee Tyson

Wed 6/17

7:10 am-9:10 pm

2 stops14h 00m

$295
Quickest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 6/18

2:00 pm-9:10 pm

2 stops7h 10m

Knoxville McGhee Tyson

Sat 6/20

8:00 am-1:25 pm

1 stop5h 25m

$342

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 6/20

7:50 am-7:35 pm

2 stops11h 45m

Knoxville McGhee Tyson

Sat 6/27

7:00 am-4:10 pm

2 stops9h 10m

$347

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 7/31

2:00 pm-9:10 pm

2 stops7h 10m

Knoxville McGhee Tyson

Mon 8/3

2:20 pm-10:45 pm

2 stops8h 25m

$347

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 9/21

2:30 pm-6:35 pm

1 stop4h 05m

Knoxville McGhee Tyson

Thu 9/24

7:10 am-7:40 pm

2 stops12h 30m

$348

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 7/1

8:30 am-8:20 pm

2 stops11h 50m

Knoxville McGhee Tyson

Wed 7/8

7:10 am-6:25 pm

2 stops11h 15m

$359
Cheapest one-way

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 8/27

6:28 pm-6:35 pm

1 stop24h 07m

$109

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 5/23

6:30 am-4:21 pm

1 stop9h 51m

$109

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/25

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Compare providers for flights from Myrtle Beach to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Knoxville

What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $228). Flying from Myrtle Beach to Knoxville in March is currently the most expensive (average of $556). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Myrtle Beach to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 27, 2026.
Get a feel of what it's like to fly with American Airlines from Myrtle Beach to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,672 reviews

Food

6.4

Crew

7.9

Entertainment

6.9

Comfort

7.2

Overall

7.1

Boarding

7.5

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.
American Airlines
7.1
Good
11,672 reviews
American Airlines
7.1
Good
11,672 reviews

Food

6.4

Crew

7.9

Entertainment

6.9

Comfort

7.2

Overall

7.1

Boarding

7.5

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Knoxville?

    For as low as $295, Southwest can have you in Knoxville from Myrtle Beach in 9h 55m. The distance from Myrtle Beach to Knoxville is about 323 mi.

  • What is the cheapest airline to fly from Myrtle Beach to Knoxville round-trip?

    According to our current data, American Airlines ($283), offers the cheapest pricing from Myrtle Beach to Knoxville. American Airlines is priced at 25% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Myrtle Beach to Knoxville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Knoxville.

  • Can I find deals for business class flights from Myrtle Beach to Knoxville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

    Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $228). Flying from Myrtle Beach to Knoxville in March is currently the most expensive (average of $556). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Myrtle Beach to Knoxville

Discover the top airline that operate flights from Myrtle Beach to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$283Average$316FlexibilityNo cancel feeOn-time71%

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