$128+ Cheap flights from Myrtle Beach to Knoxville (MYR - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/3. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — TYS
Jul 10 — Jul 171
Round-trip
1 adult, Economy
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Cheapest flights from Myrtle Beach to KnoxvilleExplore the most affordable flight options available from Myrtle Beach to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
Explore the most affordable flight options available from Myrtle Beach to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:53 pm
MYR
- TYS
1 stop26h 06m
Multiple Airlines
Tue 7/145:00 pm
TYS
- MYR
1 stop26h 37m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$288
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:25 pm
MYR
- TYS
2 stops27h 35m
Multiple Airlines
Mon 8/37:20 pm
TYS
- MYR
1 stop14h 45m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/241:13 pm
MYR
- TYS
1 stop10h 20m
Multiple Airlines
Mon 7/271:36 pm
TYS
- MYR
1 stop20h 14m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$312
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:55 am
MYR
- TYS
1 stop10h 35m
Southwest
Tue 7/78:10 am
TYS
- MYR
1 stop10h 15m
Southwest
Deal found 6/6![Southwest logo]()
$327
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:59 pm
MYR
- TYS
1 stop3h 53m
Delta
Sat 7/255:37 pm
TYS
- MYR
1 stop4h 12m
Delta
Deal found 6/8![Delta logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/203:31 pm
MYR
- TYS
1 stop24h 39m
Multiple Airlines
Sat 7/255:59 pm
TYS
- MYR
2 stops16h 53m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$340
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/242:00 pm
MYR
- TYS
2 stops7h 15m
Southwest
Mon 7/272:20 pm
TYS
- MYR
2 stops8h 30m
Southwest
Deal found 6/8![Southwest logo]()
$347
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/232:00 pm
MYR
- TYS
2 stops7h 15m
Southwest
Sun 7/268:00 am
TYS
- MYR
1 stop9h 10m
Southwest
Deal found 6/5![Southwest logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/101:13 pm
MYR
- TYS
1 stop10h 20m
Multiple Airlines
Sun 7/129:20 pm
TYS
- MYR
1 stop12h 30m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/302:00 pm
MYR
- TYS
2 stops7h 15m
Southwest
Mon 8/36:40 am
TYS
- MYR
2 stops12h 50m
Southwest
Deal found 6/8![Southwest logo]()
$353
Best flights from Myrtle Beach to KnoxvilleDiscover carefully curated flight deals from Myrtle Beach to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
Discover carefully curated flight deals from Myrtle Beach to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:00 pm
MYR
- TYS
2 stops7h 10m
Southwest
Tue 7/78:10 am
TYS
- MYR
1 stop10h 15m
Southwest
Deal found 6/6![Southwest logo]()
$327
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:45 pm
MYR
- TYS
1 stop5h 01m
Delta
Sun 10/257:20 pm
TYS
- MYR
1 stop4h 15m
Delta
Deal found 6/7![Delta logo]()
$337
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:06 pm
MYR
- TYS
1 stop5h 41m
American Airlines
Tue 6/3011:01 am
TYS
- MYR
1 stop4h 31m
American Airlines
Deal found 6/6![American Airlines logo]()
$366
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/222:28 pm
MYR
- TYS
1 stop9h 10m
Multiple Airlines
Wed 6/241:02 pm
TYS
- MYR
1 stop6h 35m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$385
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:35 pm
MYR
- TYS
1 stop6h 40m
Southwest
Mon 10/127:10 am
TYS
- MYR
1 stop5h 30m
Southwest
Deal found 6/6![Southwest logo]()
$337
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/211:41 am
MYR
- TYS
1 stop3h 08m
Delta
Sun 7/57:46 pm
TYS
- MYR
1 stop4h 16m
Delta
Deal found 6/9![Delta logo]()
$377
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/242:00 pm
MYR
- TYS
2 stops7h 15m
Southwest
Mon 7/272:20 pm
TYS
- MYR
2 stops8h 30m
Southwest
Deal found 6/8![Southwest logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:34 pm
MYR
- TYS
2 stops28h 12m
Multiple Airlines
Wed 6/241:02 pm
TYS
- MYR
1 stop6h 35m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$419
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/232:00 pm
MYR
- TYS
2 stops7h 15m
Southwest
Sun 7/268:00 am
TYS
- MYR
1 stop9h 10m
Southwest
Deal found 6/5![Southwest logo]()
$348
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/52:00 pm
MYR
- TYS
1 stop8h 30m
Southwest
Sat 7/118:00 am
TYS
- MYR
1 stop5h 25m
Southwest
Deal found 6/8![Southwest logo]()
$422
Last-minute flights from Myrtle Beach to KnoxvilleDiscover last-minute flight deals from Myrtle Beach to Knoxville. Data last updated June 10, 2026 and is based on user searches.
Discover last-minute flight deals from Myrtle Beach to Knoxville. Data last updated June 10, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:55 am
MYR
- TYS
1 stop10h 35m
Southwest
Tue 7/78:10 am
TYS
- MYR
1 stop10h 15m
Southwest
Deal found 6/6![Southwest logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:53 pm
MYR
- TYS
1 stop26h 06m
Multiple Airlines
Tue 7/145:00 pm
TYS
- MYR
1 stop26h 37m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$288
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/101:13 pm
MYR
- TYS
1 stop10h 20m
Multiple Airlines
Sun 7/129:20 pm
TYS
- MYR
1 stop12h 30m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:59 pm
MYR
- TYS
1 stop3h 53m
Delta
Sat 7/255:37 pm
TYS
- MYR
1 stop4h 12m
Delta
Deal found 6/8![Delta logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/203:31 pm
MYR
- TYS
1 stop24h 39m
Multiple Airlines
Sat 7/255:59 pm
TYS
- MYR
2 stops16h 53m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$340
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/232:00 pm
MYR
- TYS
2 stops7h 15m
Southwest
Sun 7/268:00 am
TYS
- MYR
1 stop9h 10m
Southwest
Deal found 6/5![Southwest logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/241:13 pm
MYR
- TYS
1 stop10h 20m
Multiple Airlines
Mon 7/271:36 pm
TYS
- MYR
1 stop20h 14m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$312
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/242:00 pm
MYR
- TYS
2 stops7h 15m
Southwest
Mon 7/272:20 pm
TYS
- MYR
2 stops8h 30m
Southwest
Deal found 6/8![Southwest logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:25 pm
MYR
- TYS
2 stops27h 35m
Multiple Airlines
Mon 8/37:20 pm
TYS
- MYR
1 stop14h 45m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$305
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/302:00 pm
MYR
- TYS
2 stops7h 15m
Southwest
Mon 8/36:40 am
TYS
- MYR
2 stops12h 50m
Southwest
Deal found 6/8![Southwest logo]()
$353
One-way flights from Myrtle Beach to KnoxvilleSearch for one-way flight options from Myrtle Beach to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
Search for one-way flight options from Myrtle Beach to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/38:41 pm
MYR
- TYS
1 stop26h 16m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/169:07 pm
MYR
- TYS
1 stop26h 12m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:53 pm
MYR
- TYS
1 stop26h 06m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/171:13 pm
MYR
- TYS
1 stop10h 20m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/189:58 pm
MYR
- TYS
2 stops40h 18m
Allegiant Air
Deal found 6/8![Allegiant Air logo]()
$142
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:00 am
MYR
- TYS
1 stop3h 38m
Delta
Deal found 6/8![Delta logo]()
$148
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:00 pm
MYR
- TYS
2 stops7h 10m
Southwest
Deal found 6/9![Southwest logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/153:17 pm
MYR
- TYS
1 stop23h 31m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/131:13 pm
MYR
- TYS
1 stop10h 20m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$158
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/308:30 am
MYR
- TYS
2 stops11h 50m
Southwest
Deal found 6/8![Southwest logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1611:42 am
MYR
- TYS
2 stops35h 37m
Allegiant Air
Deal found 6/8![Allegiant Air logo]()
$165
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:00 am
MYR
- TYS
1 stop3h 36m
Delta
Deal found 6/7![Delta logo]()
$169
Find flight deals from Myrtle Beach to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $288 (Kiwi.com) |
One-way from | $128 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $445 |
Cheapflights Fare Finder
Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Fri 7/3
2:00 pm-9:10 pm
2 stops7h 10m
Knoxville McGhee Tyson
Tue 7/7
8:10 am-6:25 pm
1 stop10h 15m
$327
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Fri 10/23
6:45 pm-11:46 pm
1 stop5h 01m
Knoxville McGhee Tyson
Sun 10/25
7:20 pm-11:35 pm
1 stop4h 15m
$337
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Tue 10/6
2:35 pm-9:15 pm
1 stop6h 40m
Knoxville McGhee Tyson
Mon 10/12
7:10 am-12:40 pm
1 stop5h 30m
$337
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Fri 7/24
2:00 pm-9:15 pm
2 stops7h 15m
Knoxville McGhee Tyson
Mon 7/27
2:20 pm-10:50 pm
2 stops8h 30m
$347
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Thu 7/23
2:00 pm-9:15 pm
2 stops7h 15m
Knoxville McGhee Tyson
Sun 7/26
8:00 am-5:10 pm
1 stop9h 10m
$348
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Tue 6/23
6:06 pm-11:47 pm
1 stop5h 41m
Knoxville McGhee Tyson
Tue 6/30
11:01 am-3:32 pm
1 stop4h 31m
$366
Quickest round-trip
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Thu 7/2
11:41 am-2:49 pm
1 stop3h 08m
Knoxville McGhee Tyson
Sun 7/5
7:46 pm-12:02 am
1 stop4h 16m
$377
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Mon 6/22
2:28 pm-11:38 pm
1 stop9h 10m
Knoxville McGhee Tyson
Wed 6/24
1:02 pm-7:37 pm
1 stop6h 35m
$385
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Sat 6/20
6:34 pm-10:46 pm
2 stops28h 12m
Knoxville McGhee Tyson
Wed 6/24
1:02 pm-7:37 pm
1 stop6h 35m
$419
Myrtle BeachKnoxville
MYR - TYS
MYRTYS
Myrtle Beach Intl
Sun 7/5
2:00 pm-10:30 pm
1 stop8h 30m
Knoxville McGhee Tyson
Sat 7/11
8:00 am-1:25 pm
1 stop5h 25m
$422
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Myrtle Beach to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Knoxville in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Myrtle Beach-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Myrtle Beach-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Myrtle Beach to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Myrtle Beach with our price prediction graph.
MYR-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Myrtle Beach to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 10, 2026.
Get a feel of what it's like to fly with American Airlines from Myrtle Beach to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.1
Entertainment
6.9
Food
6.4
Crew
7.9
Boarding
7.5
Comfort
7.2
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Overall
7.1
Entertainment
6.9
Food
6.4
Crew
7.9
Boarding
7.5
Comfort
7.2
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Related info for your journey
Find useful and relevant information for your journey from Myrtle Beach to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
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Top airline flying from Myrtle Beach to Knoxville
Discover the top airline that operate flights from Myrtle Beach to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$283 | Average$316 | FlexibilityNo cancel fee | On-time71% |