$127+ Cheap flights from Knoxville to Myrtle Beach (TYS - MYR)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MYR
Oct 22 — Oct 291
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Myrtle Beach with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Myrtle Beach
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to Myrtle BeachExplore the most affordable flight options available from Knoxville to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from Knoxville to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:04 pm -
1 stop14h 09m
Tue 10/274:03 pm -
1 stop18h 02m
Deal found 9/20![Multiple Airlines logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 pm -
1 stop14h 03m
Mon 11/21:53 pm -
1 stop27h 21m
Deal found 9/18![Multiple Airlines logo]()
$271
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:40 am -
1 stop4h 27m
Wed 1/66:00 am -
1 stop3h 12m
Deal found 9/19![Delta logo]()
$273
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:49 pm -
1 stop5h 13m
Mon 10/268:12 pm -
1 stop3h 43m
Deal found 9/21![American Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:37 pm -
1 stop14h 26m
Sat 11/145:58 pm -
1 stop22h 27m
Deal found 9/17![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:28 pm -
1 stop14h 35m
Fri 10/306:12 pm -
2 stops15h 53m
Deal found 9/19![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:43 pm -
1 stop15h 07m
Fri 10/236:12 pm -
1 stop15h 31m
Deal found 9/19![Multiple Airlines logo]()
$306
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/68:04 pm -
1 stop3h 51m
Sat 12/1212:02 pm -
1 stop3h 21m
Deal found 9/18![American Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:50 am -
1 stop7h 30m
Thu 12/313:25 pm -
1 stop5h 20m
Deal found 9/17![Southwest logo]()
$318
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/53:43 pm -
1 stop6h 21m
Thu 12/316:18 pm -
1 stop3h 39m
Deal found 9/17![American Airlines logo]()
$319
Best flights from Knoxville to Myrtle BeachDiscover carefully curated flight deals from Knoxville to Myrtle Beach that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from Knoxville to Myrtle Beach that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/67:25 pm -
2 stops14h 40m
Sat 12/1210:35 am -
1 stop7h 05m
Deal found 9/18![Southwest logo]()
$336
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:40 am -
1 stop4h 27m
Tue 10/276:58 pm -
1 stop3h 24m
Deal found 9/19![Delta logo]()
$376
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:58 pm -
1 stop3h 49m
Mon 10/268:12 pm -
1 stop3h 43m
Deal found 9/20![American Airlines logo]()
$410
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:56 pm -
1 stop13h 48m
Tue 10/610:45 am -
1 stop27h 57m
Deal found 9/17![Multiple Airlines logo]()
$411
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:15 am -
2 stops14h 15m
Mon 11/28:20 am -
2 stops12h 10m
Deal found 9/18![Southwest logo]()
$437
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:15 am -
2 stops9h 00m
Fri 10/233:55 pm -
1 stop6h 50m
Deal found 9/21![Southwest logo]()
$447
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:25 am -
2 stops15h 40m
Sat 10/1711:40 am -
1 stop8h 00m
Deal found 9/22![Southwest logo]()
$455
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:54 am -
2 stops24h 50m
Sun 9/272:46 pm -
1 stop25h 57m
Deal found 9/21![Multiple Airlines logo]()
$585
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:25 pm -
2 stops14h 25m
Wed 10/148:40 am -
2 stops12h 25m
Deal found 9/21![Southwest logo]()
$606
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:25 pm -
2 stops14h 20m
Fri 10/91:25 pm -
1 stop8h 10m
Deal found 9/19![Southwest logo]()
$624
Last-minute flights from Knoxville to Myrtle BeachDiscover last-minute flight deals from Knoxville to Myrtle Beach. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Myrtle Beach. Data last updated September 22, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:15 am -
1 stop25h 48m
Tue 10/134:03 pm -
1 stop18h 02m
Deal found 9/19![Multiple Airlines logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:15 am -
1 stop11h 10m
Sun 10/182:46 pm -
1 stop20h 28m
Deal found 9/20![Multiple Airlines logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/169:24 pm -
1 stop11h 49m
Mon 10/191:53 pm -
1 stop28h 21m
Deal found 9/21![Multiple Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:43 pm -
1 stop15h 07m
Fri 10/236:12 pm -
1 stop15h 31m
Deal found 9/19![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:43 pm -
1 stop15h 07m
Thu 10/222:46 pm -
1 stop21h 28m
Deal found 9/19![Multiple Airlines logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:04 pm -
1 stop14h 09m
Tue 10/274:03 pm -
1 stop18h 02m
Deal found 9/20![Multiple Airlines logo]()
$262
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:49 pm -
1 stop5h 13m
Mon 10/268:12 pm -
1 stop3h 43m
Deal found 9/21![American Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:28 pm -
1 stop14h 35m
Fri 10/306:12 pm -
2 stops15h 53m
Deal found 9/19![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 pm -
1 stop14h 03m
Mon 11/21:53 pm -
1 stop27h 21m
Deal found 9/18![Multiple Airlines logo]()
$271
One-way flights from Knoxville to Myrtle BeachSearch for one-way flight options from Knoxville to Myrtle Beach. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
Search for one-way flight options from Knoxville to Myrtle Beach. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:28 pm -
1 stop11h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$127
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:50 am -
1 stop7h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/199:54 pm -
1 stop13h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:14 pm -
2 stops20h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:05 am -
1 stop22h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$155
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:40 am -
2 stops10h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Southwest logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:54 am -
1 stop26h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$180
Find flight deals from Knoxville to Myrtle Beach
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Myrtle Beach (MYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $262 (Kiwi.com) |
One-way from | $127 (Kiwi.com) |
Popular in | March |
Cheapest in | July |
Average price | $495 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from Knoxville to Myrtle Beach that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Thu 11/26
7:50 am-3:20 pm
1 stop7h 30m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$135
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Sat 10/24
5:40 am-10:07 am
1 stop4h 27m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$137
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Fri 10/23
9:28 pm-11:44 am
2 stops14h 16m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$137
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Wed 10/21
5:40 am-10:07 am
1 stop4h 27m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$137
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Thu 10/22
5:40 am-10:07 am
1 stop4h 27m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$137
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Thu 11/26
5:40 am-10:07 am
1 stop4h 27m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$137
Quickest round-trip
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Sat 10/17
7:58 pm-11:47 pm
1 stop3h 49m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Thu 10/22
7:58 pm-11:47 pm
1 stop3h 49m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Thu 10/22
9:05 am-11:44 am
2 stops26h 39m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$166
KnoxvilleMyrtle Beach
TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl
TYSMYR
Knoxville McGhee Tyson
Sat 10/24
6:40 am-5:15 pm
2 stops10h 35m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$170
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Myrtle Beach
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Myrtle Beach in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Myrtle Beach flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Myrtle Beach flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Myrtle Beach flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Myrtle Beach flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Myrtle Beach flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Myrtle Beach
Have a flexible travel schedule? Discover the best time to fly to Myrtle Beach from Knoxville with our price prediction graph.
TYS-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Myrtle Beach
Reviews of airlines servicing Myrtle Beach
Get insights into the airlines that provide service to Myrtle Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Myrtle Beach. Reviews last updated September 22, 2026.
Read through reviews of airlines operating flights from Knoxville to Myrtle Beach, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Food
7.2
Comfort
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Overall
7.8
Food
7.2
Comfort
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Overall
7.8
Food
7.2
Comfort
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Myrtle Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Myrtle Beach?
Book flights to Myrtle Beach if you plan to visit one of these locationsConway
Pawleys Island
Sunset Beach
Surfside Beach
Garden City Beach
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Myrtle Beach flight routes
Other flight options
Other flights from Knoxville
Popular flights
Alternative routes for Knoxville to Myrtle Beach
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Myrtle Beach by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Myrtle Beach by cabin class
Find flights from Knoxville to Myrtle Beach, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Myrtle Beach
Explore flights to Myrtle Beach departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 22, 2026.
Knoxville and Myrtle Beach flights
Browse other Knoxville and Myrtle Beach flight options. Last updated on September 22, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Myrtle Beach
Discover the top 2 airlines that operate flights from Knoxville to Myrtle Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$236 | Average$331 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$273 | Average$420 | FlexibilityNo cancel fee | On-time71% |