$124+ Cheap flights from San Diego to Knoxville (SAN - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — TYS
Oct 6 — Oct 131
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Diego to Knoxville
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Best
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Cheapest flights from San Diego to KnoxvilleExplore the most affordable flight options available from San Diego to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
Explore the most affordable flight options available from San Diego to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:03 pm -
1 stop21h 11m
Mon 10/59:54 pm -
1 stop22h 05m
Deal found 9/1![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:25 am -
1 stop27h 46m
Sun 11/16:30 am -
1 stop12h 38m
Deal found 9/6![Multiple Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:53 pm -
1 stop17h 18m
Mon 10/269:42 pm -
2 stops23h 56m
Deal found 9/6![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:01 pm -
1 stop21h 17m
Fri 10/232:54 pm -
2 stops28h 55m
Deal found 9/2![Multiple Airlines logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:14 pm -
2 stops26h 25m
Sun 11/16:30 am -
1 stop12h 38m
Deal found 9/6![Multiple Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:53 pm -
1 stop17h 18m
Fri 10/3012:49 pm -
1 stop9h 58m
Deal found 9/6![Multiple Airlines logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:34 pm -
2 stops46h 36m
Fri 10/3012:49 pm -
1 stop9h 58m
Deal found 9/3![Multiple Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/179:25 pm -
1 stop8h 07m
Sat 10/248:02 pm -
1 stop6h 36m
Deal found 9/2![American Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:34 pm -
1 stop22h 15m
Mon 10/269:42 pm -
2 stops23h 56m
Deal found 9/2![Multiple Airlines logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:53 pm -
1 stop17h 18m
Thu 10/299:29 pm -
2 stops21h 39m
Deal found 9/6![Multiple Airlines logo]()
$366
Best flights from San Diego to KnoxvilleDiscover carefully curated flight deals from San Diego to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
Discover carefully curated flight deals from San Diego to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:35 am -
1 stop11h 10m
Sun 11/227:25 pm -
1 stop7h 55m
Deal found 9/2![Southwest logo]()
$420
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:30 pm -
1 stop8h 15m
Fri 10/306:45 am -
1 stop7h 42m
Deal found 9/3![United Airlines logo]()
$421
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:38 pm -
1 stop6h 44m
Mon 10/266:23 pm -
1 stop8h 01m
Deal found 9/6![Delta logo]()
$517
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:35 am -
1 stop5h 55m
Fri 11/203:40 pm -
2 stops8h 40m
Deal found 9/1![Southwest logo]()
$420
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:40 pm -
1 stop10h 35m
Mon 10/267:25 pm -
1 stop8h 10m
Deal found 9/1![Southwest logo]()
$440
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:30 am -
1 stop6h 24m
Sat 9/266:00 am -
1 stop8h 25m
Deal found 9/4![United Airlines logo]()
$503
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2212:52 pm -
1 stop8h 03m
Fri 9/255:20 pm -
1 stop8h 34m
Deal found 9/4![Delta logo]()
$528
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:45 pm -
1 stop8h 44m
Sat 9/267:33 am -
1 stop9h 36m
Deal found 9/4![Delta logo]()
$531
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2610:20 pm -
1 stop9h 24m
Fri 10/307:00 am -
1 stop6h 59m
Deal found 9/4![United Airlines logo]()
$535
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:45 am -
2 stops9h 00m
Mon 11/307:15 pm -
1 stop9h 10m
Deal found 9/3![Southwest logo]()
$532
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:57 pm -
2 stops12h 42m
Fri 11/62:38 pm -
2 stops11h 13m
Deal found 9/2![Delta logo]()
$539
Last-minute flights from San Diego to KnoxvilleDiscover last-minute flight deals from San Diego to Knoxville. Data last updated September 6, 2026 and is based on user searches.
Discover last-minute flight deals from San Diego to Knoxville. Data last updated September 6, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:03 pm -
1 stop21h 11m
Mon 10/59:54 pm -
1 stop22h 05m
Deal found 9/1![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:01 pm -
1 stop21h 17m
Fri 10/232:54 pm -
2 stops28h 55m
Deal found 9/2![Multiple Airlines logo]()
$320
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/179:25 pm -
1 stop8h 07m
Sat 10/248:02 pm -
1 stop6h 36m
Deal found 9/2![American Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:14 pm -
2 stops26h 25m
Sun 11/16:30 am -
1 stop12h 38m
Deal found 9/6![Multiple Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:34 pm -
1 stop22h 15m
Mon 10/269:42 pm -
2 stops23h 56m
Deal found 9/2![Multiple Airlines logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:34 pm -
2 stops46h 36m
Fri 10/3012:49 pm -
1 stop9h 58m
Deal found 9/3![Multiple Airlines logo]()
$362
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:25 am -
1 stop27h 46m
Sun 11/16:30 am -
1 stop12h 38m
Deal found 9/6![Multiple Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:53 pm -
1 stop17h 18m
Mon 10/269:42 pm -
2 stops23h 56m
Deal found 9/6![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:53 pm -
1 stop17h 18m
Fri 10/3012:49 pm -
1 stop9h 58m
Deal found 9/6![Multiple Airlines logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:53 pm -
1 stop17h 18m
Thu 10/299:29 pm -
2 stops21h 39m
Deal found 9/6![Multiple Airlines logo]()
$366
One-way flights from San Diego to KnoxvilleSearch for one-way flight options from San Diego to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
Search for one-way flight options from San Diego to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:54 pm -
1 stop26h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:03 pm -
1 stop21h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Multiple Airlines logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:53 pm -
1 stop17h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:14 pm -
2 stops26h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:01 pm -
1 stop21h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$175
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/309:45 pm -
1 stop9h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![United Airlines logo]()
$182
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:27 pm -
1 stop8h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![American Airlines logo]()
$206
Find flight deals from San Diego to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $271 (Kiwi.com) |
One-way from | $124 (Kiwi.com) |
Popular in | November |
Cheapest in | May |
Average price | $491 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Diego to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San DiegoKnoxville
SAN San Diego - TYS Knoxville McGhee Tyson
SANTYS
San Diego
Wed 9/30
5:54 pm-11:01 pm
1 stop26h 07m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$124
San DiegoKnoxville
SAN San Diego - TYS Knoxville McGhee Tyson
SANTYS
San Diego
Thu 10/1
9:03 pm-9:14 pm
1 stop21h 11m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$134
San DiegoKnoxville
SAN San Diego - TYS Knoxville McGhee Tyson
SANTYS
San Diego
Wed 9/30
9:45 pm-10:37 am
1 stop9h 52m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$182
San DiegoKnoxville
SAN San Diego - TYS Knoxville McGhee Tyson
SANTYS
San Diego
Mon 9/28
9:45 pm-10:37 am
1 stop9h 52m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$218
San DiegoKnoxville
SAN San Diego - TYS Knoxville McGhee Tyson
SANTYS
San Diego
Tue 10/13
7:41 pm-9:45 am
2 stops11h 04m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$223
San DiegoKnoxville
SAN San Diego - TYS Knoxville McGhee Tyson
SANTYS
San Diego
Sun 12/6
6:45 am-6:45 pm
2 stops9h 00m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$239
Quickest round-trip
San DiegoKnoxville
SAN San Diego - TYS Knoxville McGhee Tyson
SANTYS
San Diego
Thu 10/22
8:00 am-5:28 pm
1 stop6h 28m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$240
San DiegoKnoxville
SAN San Diego - TYS Knoxville McGhee Tyson
SANTYS
San Diego
Thu 11/19
6:35 am-8:45 pm
1 stop11h 10m
Knoxville McGhee Tyson
Sun 11/22
7:25 pm-12:20 am
1 stop7h 55m
$420
San DiegoKnoxville
SAN San Diego - TYS Knoxville McGhee Tyson
SANTYS
San Diego
Mon 11/16
6:35 am-3:30 pm
1 stop5h 55m
Knoxville McGhee Tyson
Fri 11/20
3:40 pm-9:20 pm
2 stops8h 40m
$420
San DiegoKnoxville
SAN San Diego - TYS Knoxville McGhee Tyson
SANTYS
San Diego
Fri 10/23
10:30 pm-9:45 am
1 stop8h 15m
Knoxville McGhee Tyson
Fri 10/30
6:45 am-11:27 am
1 stop7h 42m
$421
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from San Diego to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Diego-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Diego-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Diego-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Diego-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Diego to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Diego with our price prediction graph.
SAN-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Diego to Knoxville
How far ahead should I book a flight from San Diego to Knoxville?
Booking 32 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Diego to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from San Diego to Knoxville?
Currently, May is the cheapest month in which you can book a flight from San Diego to Knoxville (average of $414). Flying from San Diego to Knoxville in November is currently the most expensive (average of $542). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Diego to Knoxville?
Airfare is below average for this route at the moment.
San Diego to Knoxville flights typically cost between $399 and $546 in October.The cheapest round-trip price found within the last 5 days was $296 on Multiple Airlines (Oct 24-Nov 1).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 6, 2026.
See what other customers who have flown with Alaska Airlines,Delta, andUnited Airlines from San Diego to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.0
Overall
7.9
Food
7.0
Comfort
7.8
Crew
8.5
Reviews
1 / 20
2.0
MediocreArt,Dec 2025
SAN - OGG
Boarding
8.1
Entertainment
7.0
Overall
7.9
Food
7.0
Comfort
7.8
Crew
8.5
Reviews
1 / 20
2.0
MediocreArt,Dec 2025
SAN - OGG
Boarding
8.1
Entertainment
7.0
Overall
7.9
Food
7.0
Comfort
7.8
Crew
8.5
Reviews
1 / 20
2.0
MediocreArt,Dec 2025
SAN - OGG
Boarding
8.1
Entertainment
7.0
Overall
7.9
Food
7.0
Comfort
7.8
Crew
8.5
Reviews
1 / 20
2.0
MediocreArt,Dec 2025
SAN - OGG
Boarding
8.1
Entertainment
7.0
Overall
7.9
Food
7.0
Comfort
7.8
Crew
8.5
Reviews
1 / 20
2.0
MediocreArt,Dec 2025
SAN - OGG
Boarding
8.1
Entertainment
7.0
Overall
7.9
Food
7.0
Comfort
7.8
Crew
8.5
Reviews
1 / 20
2.0
MediocreArt,Dec 2025
SAN - OGG
Related info for your journey
Find useful and relevant information for your journey from San Diego to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Top 6 airlines flying from San Diego to Knoxville
Discover the top 6 airlines that operate flights from San Diego to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$65 | Average$270 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$276 | Average$471 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$277 | Average$491 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$307 | Average$486 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$336 | Average$454 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$496 | Average$798 | FlexibilityNo cancel fee | On-time75% |