HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$72+ Cheap flights from San Diego to Knoxville (SAN - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — TYS
déc. 17 — déc. 241
mer. 12/17
mer. 12/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from San Diego to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from San Diego to Knoxville McGhee Tyson are usually found in July or January, booked 62 days in advance, depart on a Wednesday or Tuesday and return on a Wednesday

Find flight deals from San Diego to Knoxville

Cheapest flights from San Diego to Knoxville
Explore the most affordable flight options available from San Diego to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on novembre 17, 2025.

This Expedia deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/156:34 amSAN - TYS
1 stop6h 23mFrontier
lun. 12/224:46 pmTYS - SAN
1 stop29h 29mFrontier
Deal found 11/16$142
This Kiwi.com deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 12/176:34 amSAN - TYS
1 stop27h 37mMultiple Airlines
lun. 1/511:22 amTYS - SAN
1 stop10h 04mMultiple Airlines
Deal found 11/15$211
This Kiwi.com deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 12/134:47 pmSAN - TYS
1 stop20h 10mMultiple Airlines
sam. 12/208:30 amTYS - SAN
2 stops37h 45mMultiple Airlines
Deal found 11/15$243
This Frontier deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 12/146:34 amSAN - TYS
1 stop6h 23mFrontier
dim. 12/214:26 pmTYS - SAN
1 stop10h 33mFrontier
Deal found 11/17$245
This Kiwi.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/151:33 pmSAN - TYS
2 stops23h 29mMultiple Airlines
lun. 12/224:46 pmTYS - SAN
1 stop29h 29mMultiple Airlines
Deal found 11/16$268
This Kiwi.com deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 12/2811:08 amSAN - TYS
2 stops25h 43mMultiple Airlines
lun. 1/511:22 amTYS - SAN
1 stop10h 04mMultiple Airlines
Deal found 11/15$305
This Expedia deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 12/284:47 pmSAN - TYS
1 stop20h 04mFrontier
lun. 1/54:46 pmTYS - SAN
1 stop24h 48mFrontier
Deal found 11/15$310
This eDestinos deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 12/144:33 pmSAN - TYS
1 stop23h 41mMultiple Airlines
dim. 12/216:30 amTYS - SAN
2 stops33h 08mMultiple Airlines
Deal found 11/17$335
This Expedia deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 12/146:34 amSAN - TYS
1 stop6h 23mMultiple Airlines
mer. 12/175:24 amTYS - SAN
1 stop7h 30mMultiple Airlines
Deal found 11/15$338

Cheap flight deals from San Diego to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated novembre 17, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$142
(Expedia)

One-way from

$72
(Frontier)

Popular in

December

Cheapest in

July

Average price

$537
Provider with most accurate pricing for San Diego-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Diego-Knoxville McGhee Tyson flights.
Search Deals
From San Diego to Knoxville McGhee Tyson
Search Deals
One-way flight from San Diego to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($53 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated novembre 17, 2025.
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.

Fly from

San Diego

Fly to

Knoxville

Route

Depart

Return

Price

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

mar. 2/24

12:03 pm-11:14 pm

1 stop8h 11m

Knoxville McGhee Tyson

sam. 2/28

6:20 am-1:50 pm

1 stop10h 30m

$277

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

sam. 5/2

12:48 pm-11:47 pm

1 stop7h 59m

Knoxville McGhee Tyson

mar. 5/5

5:56 am-11:08 am

1 stop8h 12m

$277

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

dim. 12/28

11:08 am-3:51 pm

2 stops25h 43m

Knoxville McGhee Tyson

lun. 1/5

11:22 am-6:26 pm

1 stop10h 04m

$305

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

ven. 1/9

2:24 pm-5:09 pm

2 stops23h 45m

Knoxville McGhee Tyson

lun. 1/12

7:35 am-12:14 pm

1 stop7h 39m

$315

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

dim. 12/14

4:33 pm-7:14 pm

1 stop23h 41m

Knoxville McGhee Tyson

dim. 12/21

6:30 am-12:38 pm

2 stops33h 08m

$335

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

mer. 12/24

11:52 am-11:13 pm

1 stop8h 21m

Knoxville McGhee Tyson

mar. 1/13

5:40 am-9:58 am

1 stop7h 18m

$338

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

dim. 12/14

6:34 am-3:57 pm

1 stop6h 23m

Knoxville McGhee Tyson

mer. 12/17

1:14 pm-10:47 pm

2 stops12h 33m

$343

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

sam. 4/11

10:25 pm-10:08 am

1 stop8h 43m

Knoxville McGhee Tyson

jeu. 4/16

9:15 am-1:38 pm

1 stop7h 23m

$354

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

ven. 2/20

7:02 am-5:30 pm

1 stop7h 28m

Knoxville McGhee Tyson

ven. 2/27

12:19 pm-6:14 pm

1 stop8h 55m

$354

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

jeu. 12/25

6:25 am-3:31 pm

1 stop6h 06m

$72

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/15

Showing 1-10 of 18 results
1
2

Compare providers for flights from San Diego to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to Knoxville in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Diego-Knoxville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on San Diego-Knoxville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from San Diego-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Diego-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Diego to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Knoxville

How far ahead should I book a flight from San Diego to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Diego to Knoxville. Price data was last updated on November 14, 2025.

Booking 62 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Diego to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Diego to Knoxville?

Currently, January is the cheapest month in which you can book a flight from San Diego to Knoxville (average of $42). Flying from San Diego to Knoxville in March is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to TYS?

Find hourly flight availability from San Diego to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated novembre 17, 2025.

It’s typically best to fly out from San Diego to Knoxville at noon. Doing so could potentially save you 21% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from San Diego to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from San Diego to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Diego to Knoxville flight should consider departing on Saturday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated novembre 17, 2025.
See what other customers who have flown with Alaska Airlines, Delta, and United Airlines from San Diego to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
11,314 reviews

Food

7.1

Boarding

8.1

Overall

8.0

Comfort

7.8

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
11,314 reviews
Alaska Airlines
8.0
Very good
11,314 reviews

Food

7.1

Boarding

8.1

Overall

8.0

Comfort

7.8

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
7.9
Good
8,008 reviews
Alaska Airlines
8.0
Very good
11,314 reviews

Food

7.1

Boarding

8.1

Overall

8.0

Comfort

7.8

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
United Airlines
7.4
Good
9,015 reviews
Alaska Airlines
8.0
Very good
11,314 reviews

Food

7.1

Boarding

8.1

Overall

8.0

Comfort

7.8

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
11,048 reviews
Alaska Airlines
8.0
Very good
11,314 reviews

Food

7.1

Boarding

8.1

Overall

8.0

Comfort

7.8

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,103 reviews
Alaska Airlines
8.0
Very good
11,314 reviews

Food

7.1

Boarding

8.1

Overall

8.0

Comfort

7.8

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Diego to Knoxville?

    A quick flight from San Diego to Knoxville can take about 7h 59m. Delta provides one of the quickest options available for as low as $277. Airlines will cover a distance of 1897 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from San Diego to Knoxville round-trip?

    Cheapflights users have booked flights from San Diego to Knoxville round-trip from $84. Other airlines that can offer you cheap pricing are United Airlines, from $228, and American Airlines, from $276. These flights start at 80% lower than the current average price 3 months from now.

  • Can I find deals for flights from San Diego to Knoxville that include hotel bookings?

    Yes. In addition to deals on San Diego to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Knoxville.

  • Can I find deals for business class flights from San Diego to Knoxville?

    Yes. Cheapflights offers flight deals from San Diego to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from San Diego to Knoxville (average of $42). Flying from San Diego to Knoxville in March is currently the most expensive (average of $283). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Crossville
Corbin
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Diego to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to Nashville flights
Ontario to Nashville flights
San Francisco to Nashville flights
Santa Ana to Nashville flights
Los Angeles to Memphis flights
San Diego to Nashville flights
Los Angeles to Knoxville flights
Las Vegas to Nashville flights
Burbank to Nashville flights
Sacramento to Nashville flights
San Jose to Nashville flights
Ontario to Memphis flights
San Francisco to Knoxville flights
Fresno to Nashville flights
Long Beach to Nashville flights
Oakland to Nashville flights
San Francisco to Memphis flights
Bakersfield to Nashville flights
San Diego to Memphis flights
Reno to Nashville flights
Santa Ana to Memphis flights
Ontario to Knoxville flights
Palm Springs to Nashville flights
Las Vegas to Knoxville flights
Sacramento to Knoxville flights
San Jose to Knoxville flights
Burbank to Memphis flights
Las Vegas to Memphis flights
Los Angeles to Chattanooga flights
Long Beach to Memphis flights
Burbank to Knoxville flights
San Francisco to Chattanooga flights
Santa Ana to Knoxville flights
Santa Ana to Chattanooga flights
Reno to Memphis flights
San Jose to Memphis flights
San Luis Obispo to Nashville flights
Sacramento to Chattanooga flights
Medford to Nashville flights
Ontario to Chattanooga flights
Oakland to Memphis flights
San Luis Obispo to Knoxville flights
Santa Rosa to Nashville flights
Monterey to Nashville flights
San Diego to Chattanooga flights
Fresno to Knoxville flights
Sacramento to Memphis flights
San Diego to Blountville flights
Fresno to Chattanooga flights

Top 5 airlines flying from San Diego to Knoxville

Discover the top 5 airlines that operate flights from San Diego to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated novembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$84Average$324FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$228Average$501FlexibilityNo cancel feeOn-time69%
DeltaCheapest$276Average$399FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$276Average$457FlexibilityNo cancel feeOn-time71%
Alaska AirlinesCheapest$378Average$798FlexibilityNo cancel feeOn-time75%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.