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$169+ Cheap flights from Knoxville to San Diego (TYS - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAN
Jul 7 — Jul 141
Mon 7/7
Mon 7/14
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Diego are usually found in January or February, booked 75 days in advance, depart on a Wednesday or Thursday and return on a Wednesday

Cheap flight deals from Knoxville to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 2, 2025.

Round-trip from

$252
(FlightHub)

One-way from

$169
(Mytrip)

Popular in

April

Cheapest in

January

Average price

$391
From Knoxville McGhee Tyson to San Diego
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One-way flight from Knoxville McGhee Tyson to San Diego
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Highest demand for flights based on searches. 14% potential increase in price ($70 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Knoxville to San Diego

Cheapest flights from Knoxville to San Diego
Explore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

This FlightHub deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/188:26 pmTYS - SAN
1 stop6h 27mFrontier
Sun 9/219:03 pmSAN - TYS
1 stop19h 38mFrontier
Deal found 6/30$252
This Mytrip deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:30 amTYS - SAN
1 stop10h 41mMultiple Airlines
Thu 10/165:29 pmSAN - TYS
2 stops16h 54mMultiple Airlines
Deal found 7/1$267
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/127:00 amTYS - SAN
1 stop7h 33mUnited Airlines
Tue 8/1912:01 pmSAN - TYS
1 stop8h 43mUnited Airlines
Deal found 6/30$277
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/612:56 pmTYS - SAN
1 stop9h 20mAmerican Airlines
Mon 8/117:15 amSAN - TYS
1 stop7h 34mAmerican Airlines
Deal found 6/30$283
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/94:02 pmTYS - SAN
1 stop6h 54mDelta
Tue 7/1510:15 pmSAN - TYS
1 stop8h 59mDelta
Deal found 6/30$353

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.

Fly from

Knoxville

Fly to

San Diego

Route

Depart

Return

Price

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 9/18

8:26 pm-11:53 pm

1 stop6h 27m

San Diego

Sun 9/21

9:03 pm-7:41 pm

1 stop19h 38m

$252

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 7/29

4:55 pm-9:55 am

2 stops20h 00m

San Diego

Thu 7/31

9:40 pm-1:38 pm

1 stop12h 58m

$269

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 8/12

7:00 am-11:33 am

1 stop7h 33m

San Diego

Tue 8/19

12:01 pm-11:44 pm

1 stop8h 43m

$277

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 8/6

12:56 pm-7:16 pm

1 stop9h 20m

San Diego

Mon 8/11

7:15 am-5:49 pm

1 stop7h 34m

$283

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Tue 7/22

6:19 pm-9:35 pm

1 stop6h 16m

San Diego

Mon 7/28

10:15 pm-10:14 am

1 stop8h 59m

$289

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Wed 8/6

2:23 pm-12:05 am

2 stops12h 42m

San Diego

Mon 8/11

6:15 am-5:49 pm

1 stop8h 34m

$403

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 7/10

5:25 pm-11:52 pm

1 stop9h 27m

$198

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 9/6

8:23 am-2:11 pm

1 stop8h 48m

$216

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Sat 7/5

11:41 am-6:05 pm

1 stop9h 24m

$221

KnoxvilleSan Diego

TYS - SAN

TYSSAN

Knoxville McGhee Tyson

Thu 7/10

6:00 am-12:04 pm

2 stops33h 04m

$251

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 12 results
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Best time to book a flight from Knoxville to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Diego

How far ahead should I book a flight from Knoxville to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Diego. Price data was last updated on June 27, 2025.

The best time to book flights from Knoxville to San Diego is 75 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Diego?

Currently, August is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $286). Flying from Knoxville to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SAN?

Find hourly flight availability from Knoxville to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to San Diego in the evening. If you’re flexible enough to do this you can expect to save up to 17% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Knoxville to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to San Diego flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated July 2, 2025.
Get a feel of what it's like to fly with Alaska Airlines, Delta, and United Airlines from Knoxville to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,983 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,861 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
5.9
Fair
3,290 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to San Diego round-trip?

    Frontier, at $252, was found to be the cheapest airline from Knoxville to San Diego.Alternate airlines to your destination round-trip include United Airlines and American Airlines. Frontier is priced at 36% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Knoxville to San Diego one-way?

    One-way options have recently been found by users for as low as $198 on Frontier. Other airlines that offer cheap prices include American Airlines from $216 and Delta from $240 one-way.

  • Can I find deals for flights from Knoxville to San Diego that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Diego.

  • Can I find deals for business class flights from Knoxville to San Diego?

    Yes. Cheapflights offers flight deals from Knoxville to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $286). Flying from Knoxville to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
National City
Lemon Grove
Imperial Beach
La Mesa
Poway
Alpine
Santee

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Top 5 airlines flying from Knoxville to San Diego

Discover the top 5 airlines that operate flights from Knoxville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$150Average$204FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$258Average$446FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$262Average$415FlexibilityNo cancel feeOn-time71%
DeltaCheapest$276Average$374FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$366Average$503FlexibilityNo cancel feeOn-time75%

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