$141+ Cheap flights from Knoxville to San Diego (TYS - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAN
Sep 18 — Sep 251
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to San Diego
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Cheapest flights from Knoxville to San DiegoExplore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2026.
Explore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:30 am -
1 stop20h 29m
Thu 11/58:32 pm -
1 stop23h 03m
Deal found 8/19![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:30 am -
1 stop20h 26m
Thu 10/299:57 am -
1 stop9h 13m
Deal found 8/15![Multiple Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/127:55 am -
1 stop7h 19m
Wed 12/168:00 am -
1 stop9h 09m
Deal found 8/19![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/174:50 pm -
1 stop8h 15m
Mon 9/2110:40 pm -
1 stop10h 25m
Deal found 8/16![Southwest logo]()
$322
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/64:20 pm -
2 stops8h 45m
Tue 10/139:35 am -
2 stops8h 25m
Deal found 8/18![Southwest logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Sun 11/16:30 am -
1 stop20h 29m
Wed 11/49:57 am -
2 stops31h 46m
Deal found 8/17![Multiple Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:05 am -
2 stops9h 35m
Sat 12/125:45 pm -
2 stops15h 25m
Deal found 8/17![Southwest logo]()
$339
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:35 am -
1 stop7h 03m
Sat 9/512:45 pm -
1 stop6h 54m
Deal found 8/14![Delta logo]()
$340
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:16 pm -
1 stop7h 32m
Thu 10/229:45 pm -
1 stop8h 49m
Deal found 8/17![Delta logo]()
$348
Best flights from Knoxville to San DiegoDiscover carefully curated flight deals from Knoxville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 19, 2026.
Discover carefully curated flight deals from Knoxville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 19, 2026.
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:45 pm -
2 stops7h 15m
Tue 9/297:20 am -
1 stop8h 40m
Deal found 8/14![Southwest logo]()
$322
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:16 pm -
1 stop7h 32m
Thu 10/229:45 pm -
1 stop8h 49m
Deal found 8/17![Delta logo]()
$348
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:43 am -
2 stops12h 41m
Mon 11/27:41 pm -
2 stops11h 12m
Deal found 8/18![United Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:40 am -
2 stops8h 40m
Fri 10/309:50 am -
2 stops9h 50m
Deal found 8/18![Southwest logo]()
$359
This Southwest deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:50 pm -
1 stop8h 15m
Fri 9/2510:40 pm -
1 stop10h 15m
Deal found 8/19![Southwest logo]()
$408
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:20 am -
1 stop10h 49m
Fri 10/3010:30 pm -
1 stop8h 37m
Deal found 8/15![United Airlines logo]()
$449
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2410:42 am -
2 stops13h 03m
Fri 10/3010:20 pm -
1 stop9h 24m
Deal found 8/17![United Airlines logo]()
$450
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:15 am -
2 stops8h 20m
Mon 10/511:40 am -
2 stops8h 00m
Deal found 8/18![Southwest logo]()
$435
Last-minute flights from Knoxville to San DiegoDiscover last-minute flight deals from Knoxville to San Diego. Data last updated August 19, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Diego. Data last updated August 19, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:35 am -
1 stop7h 03m
Sat 9/512:45 pm -
1 stop6h 54m
Deal found 8/14![Delta logo]()
$340
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:40 am -
1 stop7h 22m
Sat 9/512:01 pm -
1 stop6h 44m
Deal found 8/17![United Airlines logo]()
$387
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:00 pm -
2 stops9h 05m
Sat 9/56:20 am -
2 stops8h 25m
Deal found 8/17![Southwest logo]()
$397
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:00 am -
1 stop6h 10m
Sun 9/66:50 am -
2 stops8h 50m
Deal found 8/18![Southwest logo]()
$392
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/611:57 am -
1 stop6h 42m
Sat 9/191:50 pm -
1 stop6h 32m
Deal found 8/17![American Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1210:45 am -
2 stops9h 25m
Sat 9/1912:04 pm -
1 stop6h 41m
Deal found 8/15![United Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/124:55 pm -
2 stops9h 20m
Sat 9/196:20 am -
2 stops8h 25m
Deal found 8/15![Southwest logo]()
$398
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:55 pm -
2 stops9h 00m
Tue 9/227:05 am -
2 stops8h 55m
Deal found 8/18![Southwest logo]()
$358
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/174:50 pm -
1 stop8h 15m
Mon 9/2110:40 pm -
1 stop10h 25m
Deal found 8/16![Southwest logo]()
$322
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/174:50 pm -
1 stop8h 15m
Sun 9/2010:25 pm -
2 stops12h 00m
Deal found 8/16![Southwest logo]()
$403
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:20 pm -
1 stop8h 26m
Mon 10/510:20 pm -
1 stop8h 57m
Deal found 8/17![Delta logo]()
$317
One-way flights from Knoxville to San DiegoSearch for one-way flight options from Knoxville to San Diego. Find affordable one-way fares based on user searches. Data last updated August 19, 2026.
Search for one-way flight options from Knoxville to San Diego. Find affordable one-way fares based on user searches. Data last updated August 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:00 am -
2 stops53h 43m
Deal found 8/19![Multiple Airlines logo]()
$141
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:15 pm -
1 stop8h 50m
Deal found 8/16![Southwest logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/122:47 pm -
2 stops21h 55m
Deal found 8/15![Multiple Airlines logo]()
$162
This Southwest deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:55 pm -
2 stops9h 00m
Deal found 8/19![Southwest logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/281:55 pm -
2 stops28h 46m
Deal found 8/16![Multiple Airlines logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:28 am -
2 stops36h 21m
Deal found 8/16![Multiple Airlines logo]()
$193
Find flight deals from Knoxville to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $276 (Kiwi.com) |
One-way from | $141 (Kiwi.com) |
Popular in | July |
Cheapest in | February |
Average price | $405 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 19, 2026.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Thu 9/24
5:45 pm-10:00 pm
2 stops7h 15m
San Diego
Tue 9/29
7:20 am-7:00 pm
1 stop8h 40m
$322
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Thu 10/8
7:16 pm-11:48 pm
1 stop7h 32m
San Diego
Thu 10/22
9:45 pm-9:34 am
1 stop8h 49m
$348
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Sat 10/24
6:40 am-12:20 pm
2 stops8h 40m
San Diego
Fri 10/30
9:50 am-10:40 pm
2 stops9h 50m
$359
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Fri 9/18
4:50 pm-10:05 pm
1 stop8h 15m
San Diego
Fri 9/25
10:40 pm-11:55 am
1 stop10h 15m
$408
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Thu 10/29
10:43 am-8:24 pm
2 stops12h 41m
San Diego
Mon 11/2
7:41 pm-9:53 am
2 stops11h 12m
$427
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Thu 10/1
7:15 am-12:35 pm
2 stops8h 20m
San Diego
Mon 10/5
11:40 am-10:40 pm
2 stops8h 00m
$435
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Thu 10/29
11:20 am-7:09 pm
1 stop10h 49m
San Diego
Fri 10/30
10:30 pm-10:07 am
1 stop8h 37m
$449
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Sat 10/24
10:42 am-8:45 pm
2 stops13h 03m
San Diego
Fri 10/30
10:20 pm-10:44 am
1 stop9h 24m
$450
Cheapest one-way
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Thu 9/24
5:45 pm-11:30 pm
1 stop8h 45m
$159
Quickest one-way
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Tue 11/10
5:40 pm-10:40 pm
1 stop8h 00m
$159
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Diego in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Knoxville-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Knoxville with our price prediction graph.
TYS-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Diego
Prices
More
How far ahead should I book a flight from Knoxville to San Diego?
The best time to book flights from Knoxville to San Diego is 29 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Diego?
Currently, February is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $303). Flying from Knoxville to San Diego in July is currently the most expensive (average of $544). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to San Diego?
Airfare is below average for this route at the moment.
Knoxville to San Diego flights typically cost between $372 and $554 in November.The cheapest round-trip price found within the last 5 days was $276 on Multiple Airlines (Nov 1-Nov 5).
What’s the top layover airport for flights from Knoxville to San Diego?
Share of 1-stop round-trip flights from Knoxville to San Diego chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 55% of 1-stop itineraries from Knoxville to San Diego on Cheapflights.
What’s the cheapest layover airport for flights from Knoxville to San Diego?
Average round-trip fare for 1-stop flights from Knoxville to San Diego, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $250.
What’s the fastest layover option from Knoxville to San Diego?
Shortest average travel time for 1-stop one-way flights from Knoxville to San Diego, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 6h 56m.
Which airport typically offers the quickest layover for flights from Knoxville to San Diego?
Average layover duration for 1-stop one-way flights from Knoxville to San Diego, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 54m.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated August 19, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Knoxville to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
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San Ysidro
La Mesa
Santee
Julian
Lemon Grove
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Knoxville and San Diego flights
Browse other Knoxville and San Diego flight options. Last updated on August 19, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on August 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 19, 2026.
Top 6 airlines flying from Knoxville to San Diego
Discover the top 6 airlines that operate flights from Knoxville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$145 | Average$250 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$218 | Average$436 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$250 | Average$413 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$276 | Average$430 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$277 | Average$489 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$354 | Average$406 | FlexibilityNo cancel fee | On-time63% |