$140+ Cheap flights from Knoxville to San Diego (TYS - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAN
Nov 19 — Nov 261
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to San Diego
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Cheapest flights from Knoxville to San DiegoExplore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
Explore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:32 pm -
1 stop9h 24m
Sat 11/147:15 am -
1 stop8h 20m
Deal found 10/19![American Airlines logo]()
$279
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:00 am -
1 stop6h 59m
Sat 11/2110:20 pm -
1 stop9h 24m
Deal found 10/19![United Airlines logo]()
$310
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:40 am -
1 stop7h 09m
Wed 11/1811:39 am -
1 stop6h 50m
Deal found 10/19![Delta logo]()
$313
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:45 am -
1 stop7h 42m
Tue 11/246:45 am -
1 stop6h 19m
Deal found 10/19![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:40 am -
1 stop7h 09m
Sat 11/147:20 am -
2 stops11h 52m
Deal found 10/19![Delta logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:15 pm -
1 stop13h 47m
Thu 12/108:57 am -
2 stops25h 46m
Deal found 10/16![Multiple Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:15 pm -
1 stop8h 55m
Sun 12/611:05 am -
1 stop6h 30m
Deal found 10/19![Southwest logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/48:00 am -
2 stops29h 19m
Mon 12/78:57 am -
1 stop8h 28m
Deal found 10/15![Multiple Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:30 am -
1 stop9h 41m
Wed 11/186:15 am -
1 stop7h 33m
Deal found 10/15![American Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:05 am -
2 stops8h 55m
Sat 11/2110:35 pm -
1 stop10h 35m
Deal found 10/19![Southwest logo]()
$394
Best flights from Knoxville to San DiegoDiscover carefully curated flight deals from Knoxville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
Discover carefully curated flight deals from Knoxville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:15 pm -
1 stop8h 55m
Sun 12/611:05 am -
1 stop6h 30m
Deal found 10/19![Southwest logo]()
$378
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/124:01 pm -
1 stop6h 58m
Wed 12/168:00 am -
1 stop6h 30m
Deal found 10/19![Delta logo]()
$431
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:33 am -
2 stops9h 44m
Wed 11/188:45 am -
2 stops12h 14m
Deal found 10/15![United Airlines logo]()
$511
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/57:05 am -
2 stops7h 45m
Thu 1/146:55 am -
1 stop5h 50m
Deal found 10/16![Southwest logo]()
$441
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:00 am -
1 stop9h 08m
Mon 11/3010:30 pm -
1 stop8h 31m
Deal found 10/19![Delta logo]()
$465
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:05 am -
2 stops8h 05m
Mon 11/99:10 am -
2 stops8h 25m
Deal found 10/15![Southwest logo]()
$447
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:45 am -
1 stop7h 42m
Fri 11/610:30 pm -
1 stop8h 37m
Deal found 10/16![United Airlines logo]()
$534
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:10 am -
2 stops10h 00m
Sat 12/123:20 pm -
2 stops17h 50m
Deal found 10/18![Southwest logo]()
$453
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:00 pm -
1 stop7h 32m
Wed 12/168:40 am -
2 stops12h 19m
Deal found 10/18![United Airlines logo]()
$556
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/157:05 am -
2 stops9h 25m
Mon 12/212:00 pm -
1 stop5h 40m
Deal found 10/16![Southwest logo]()
$470
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:45 am -
2 stops11h 47m
Sat 11/2110:20 pm -
1 stop9h 24m
Deal found 10/15![United Airlines logo]()
$556
Last-minute flights from Knoxville to San DiegoDiscover last-minute flight deals from Knoxville to San Diego. Data last updated October 20, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Diego. Data last updated October 20, 2026 and is based on user searches.
This WAYA deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WAYA is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:30 am -
1 stop20h 27m
Mon 11/98:20 am -
1 stop9h 59m
Deal found 10/15![Multiple Airlines logo]()
$415
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:32 pm -
1 stop9h 24m
Sat 11/147:15 am -
1 stop8h 20m
Deal found 10/19![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:40 am -
1 stop7h 09m
Wed 11/1811:39 am -
1 stop6h 50m
Deal found 10/19![Delta logo]()
$313
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:40 am -
1 stop7h 09m
Sat 11/147:20 am -
2 stops11h 52m
Deal found 10/19![Delta logo]()
$375
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:30 am -
1 stop9h 41m
Wed 11/186:15 am -
1 stop7h 33m
Deal found 10/15![American Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:00 am -
2 stops10h 55m
Sat 11/146:26 pm -
2 stops12h 27m
Deal found 10/19![United Airlines logo]()
$409
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:30 am -
1 stop20h 27m
Sun 11/221:02 pm -
2 stops31h 27m
Deal found 10/18![Multiple Airlines logo]()
$414
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:45 am -
1 stop7h 42m
Tue 11/246:45 am -
1 stop6h 19m
Deal found 10/19![United Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:00 am -
1 stop6h 59m
Sat 11/2110:20 pm -
1 stop9h 24m
Deal found 10/19![United Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:05 am -
2 stops8h 55m
Sat 11/2110:35 pm -
1 stop10h 35m
Deal found 10/19![Southwest logo]()
$394
One-way flights from Knoxville to San DiegoSearch for one-way flight options from Knoxville to San Diego. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
Search for one-way flight options from Knoxville to San Diego. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:45 am -
1 stop8h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![United Airlines logo]()
$140
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:15 pm -
1 stop8h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Southwest logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:00 am -
2 stops35h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$177
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:40 am -
1 stop20h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Multiple Airlines logo]()
$196
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:17 pm -
1 stop8h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Delta logo]()
$200
This Southwest deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/237:15 pm -
2 stops15h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Southwest logo]()
$227
Find flight deals from Knoxville to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $279 (American Airlines) |
One-way from | $140 (United Airlines) |
Popular in | July |
Cheapest in | February |
Average price | $481 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Thu 11/26
5:45 am-11:43 am
1 stop8h 58m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$140
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Tue 11/10
5:15 pm-11:10 pm
1 stop8h 55m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$174
Quickest round-trip
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Fri 12/11
6:17 pm-11:38 pm
1 stop8h 21m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$200
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Fri 11/6
7:00 am-9:19 pm
1 stop17h 19m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$214
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Wed 12/23
12:40 pm-8:55 pm
1 stop11h 15m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$221
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Mon 12/21
7:15 pm-7:15 am
2 stops15h 00m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$255
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Tue 11/24
6:40 am-7:55 am
3 stops28h 15m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$257
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Thu 12/3
5:15 pm-11:10 pm
1 stop8h 55m
San Diego
Sun 12/6
11:05 am-8:35 pm
1 stop6h 30m
$378
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Sat 12/12
4:01 pm-7:59 pm
1 stop6h 58m
San Diego
Wed 12/16
8:00 am-5:30 pm
1 stop6h 30m
$431
KnoxvilleSan Diego
TYS Knoxville McGhee Tyson - SAN San Diego
TYSSAN
Knoxville McGhee Tyson
Tue 1/5
7:05 am-11:50 am
2 stops7h 45m
San Diego
Thu 1/14
6:55 am-3:45 pm
1 stop5h 50m
$441
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Diego in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Knoxville-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Knoxville with our price prediction graph.
TYS-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Diego
Prices
More
How far ahead should I book a flight from Knoxville to San Diego?
The best time to book flights from Knoxville to San Diego is 29 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Diego?
Currently, February is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $303). Flying from Knoxville to San Diego in July is currently the most expensive (average of $544). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to San Diego?
Airfare is below average for this route at the moment.
Knoxville to San Diego flights typically cost between $385 and $564 in December.The cheapest round-trip price found within the last 5 days was $279 on Delta (Dec 12-Dec 15).
What’s the top layover airport for flights from Knoxville to San Diego?
Share of 1-stop round-trip flights from Knoxville to San Diego chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 75% of 1-stop itineraries from Knoxville to San Diego on Cheapflights.
What’s the cheapest layover airport for flights from Knoxville to San Diego?
Average round-trip fare for 1-stop flights from Knoxville to San Diego, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $250.
What’s the fastest layover option from Knoxville to San Diego?
Shortest average travel time for 1-stop one-way flights from Knoxville to San Diego, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 6h 56m.
Which airport typically offers the quickest layover for flights from Knoxville to San Diego?
Average layover duration for 1-stop one-way flights from Knoxville to San Diego, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 54m.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 20, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Knoxville to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Overall
7.9
Entertainment
7.4
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Overall
7.9
Entertainment
7.4
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Overall
7.9
Entertainment
7.4
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Overall
7.9
Entertainment
7.4
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Overall
7.9
Entertainment
7.4
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Overall
7.9
Entertainment
7.4
Comfort
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Knoxville and San Diego flights
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Top 6 airlines flying from Knoxville to San Diego
Discover the top 6 airlines that operate flights from Knoxville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$145 | Average$264 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$218 | Average$436 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$250 | Average$407 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$276 | Average$474 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$316 | Average$499 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$362 | Average$414 | FlexibilityNo cancel fee | On-time63% |