$115+ Cheap flights from Knoxville to San Diego (TYS - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAN
Jun 8 — Jun 151
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to San DiegoExplore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 9, 2026.
Explore the most affordable flight options available from Knoxville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 9, 2026.
This Frontier deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- SAN
1 stop15h 10m
Frontier
Tue 6/91:28 pm
SAN
- TYS
1 stop27h 09m
Frontier
Deal found 5/7![Frontier logo]()
$247
This CheapOair deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:32 pm
TYS
- SAN
1 stop15h 33m
Frontier
Fri 8/1410:04 am
SAN
- TYS
1 stop6h 32m
Frontier
Deal found 5/8![Frontier logo]()
$254
This CheapOair deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:32 pm
TYS
- SAN
1 stop15h 10m
Frontier
Mon 6/226:25 am
SAN
- TYS
1 stop10h 12m
Frontier
Deal found 5/8![Frontier logo]()
$260
This Frontier deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
TYS
- SAN
1 stop6h 31m
Frontier
Fri 6/56:25 am
SAN
- TYS
1 stop10h 08m
Frontier
Deal found 5/7![Frontier logo]()
$270
This CheapOair deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:32 pm
TYS
- SAN
1 stop15h 10m
Frontier
Fri 6/126:25 am
SAN
- TYS
1 stop10h 12m
Frontier
Deal found 5/8![Frontier logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:00 am
TYS
- SAN
2 stops29h 42m
Multiple Airlines
Tue 6/91:28 pm
SAN
- TYS
1 stop27h 09m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:47 pm
TYS
- SAN
1 stop7h 44m
Multiple Airlines
Thu 8/134:17 pm
SAN
- TYS
2 stops18h 40m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/287:00 am
TYS
- SAN
1 stop29h 09m
Multiple Airlines
Wed 7/89:53 pm
SAN
- TYS
2 stops35h 10m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:46 pm
TYS
- SAN
1 stop21h 02m
Multiple Airlines
Wed 6/179:43 am
SAN
- TYS
2 stops47h 16m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:00 am
TYS
- SAN
1 stop28h 42m
Multiple Airlines
Sun 6/146:25 am
SAN
- TYS
2 stops26h 34m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:32 pm
TYS
- SAN
1 stop15h 37m
Multiple Airlines
Wed 6/179:43 am
SAN
- TYS
2 stops47h 16m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/287:00 am
TYS
- SAN
1 stop29h 09m
Multiple Airlines
Sat 7/44:17 pm
SAN
- TYS
1 stop27h 39m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$317
Best flights from Knoxville to San DiegoDiscover carefully curated flight deals from Knoxville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 9, 2026.
Discover carefully curated flight deals from Knoxville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 9, 2026.
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/124:38 pm
TYS
- SAN
1 stop9h 22m
Delta
Tue 8/181:58 pm
SAN
- TYS
1 stop6h 54m
Delta
Deal found 5/8![Delta logo]()
$347
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:00 am
TYS
- SAN
2 stops13h 26m
United Airlines
Tue 8/1811:00 am
SAN
- TYS
1 stop8h 44m
United Airlines
Deal found 5/9![United Airlines logo]()
$442
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:50 pm
TYS
- SAN
1 stop9h 45m
Southwest
Tue 6/96:40 am
SAN
- TYS
2 stops8h 40m
Southwest
Deal found 5/4![Southwest logo]()
$444
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:51 am
TYS
- SAN
1 stop9h 29m
Delta
Wed 6/106:15 am
SAN
- TYS
1 stop8h 47m
Delta
Deal found 5/6![Delta logo]()
$368
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:30 am
TYS
- SAN
2 stops13h 56m
United Airlines
Sat 8/156:55 pm
SAN
- TYS
2 stops12h 41m
United Airlines
Deal found 5/5![United Airlines logo]()
$457
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:00 am
TYS
- SAN
1 stop8h 21m
United Airlines
Wed 6/37:41 pm
SAN
- TYS
2 stops11h 02m
United Airlines
Deal found 5/7![United Airlines logo]()
$462
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:45 am
TYS
- SAN
1 stop8h 04m
United Airlines
Sat 8/88:42 pm
SAN
- TYS
2 stops10h 01m
United Airlines
Deal found 5/8![United Airlines logo]()
$497
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:45 am
TYS
- SAN
1 stop8h 04m
United Airlines
Wed 7/229:59 pm
SAN
- TYS
1 stop9h 43m
United Airlines
Deal found 5/6![United Airlines logo]()
$502
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/31:35 pm
TYS
- SAN
1 stop9h 48m
United Airlines
Tue 7/78:32 pm
SAN
- TYS
2 stops10h 11m
United Airlines
Deal found 5/8![United Airlines logo]()
$502
Last-minute flights from Knoxville to San DiegoDiscover last-minute flight deals from Knoxville to San Diego. Data last updated May 9, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Diego. Data last updated May 9, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
TYS
- SAN
1 stop6h 31m
Frontier
Fri 6/56:25 am
SAN
- TYS
1 stop10h 08m
Frontier
Deal found 5/7![Frontier logo]()
$270
This Frontier deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- SAN
1 stop15h 10m
Frontier
Tue 6/91:28 pm
SAN
- TYS
1 stop27h 09m
Frontier
Deal found 5/7![Frontier logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:00 am
TYS
- SAN
2 stops29h 42m
Multiple Airlines
Tue 6/91:28 pm
SAN
- TYS
1 stop27h 09m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:00 am
TYS
- SAN
1 stop19h 50m
Multiple Airlines
Thu 6/119:43 am
SAN
- TYS
2 stops27h 57m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$319
This CheapOair deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:32 pm
TYS
- SAN
1 stop15h 10m
Frontier
Fri 6/126:25 am
SAN
- TYS
1 stop10h 12m
Frontier
Deal found 5/8![Frontier logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:25 am
TYS
- SAN
2 stops43h 25m
Multiple Airlines
Fri 6/126:25 am
SAN
- TYS
1 stop10h 12m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:00 am
TYS
- SAN
1 stop28h 42m
Multiple Airlines
Sun 6/146:25 am
SAN
- TYS
2 stops26h 34m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:46 pm
TYS
- SAN
1 stop21h 02m
Multiple Airlines
Wed 6/179:43 am
SAN
- TYS
2 stops47h 16m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:32 pm
TYS
- SAN
1 stop15h 37m
Multiple Airlines
Wed 6/179:43 am
SAN
- TYS
2 stops47h 16m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$307
This CheapOair deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:32 pm
TYS
- SAN
1 stop15h 10m
Frontier
Mon 6/226:25 am
SAN
- TYS
1 stop10h 12m
Frontier
Deal found 5/8![Frontier logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/287:00 am
TYS
- SAN
1 stop29h 09m
Multiple Airlines
Wed 7/89:53 pm
SAN
- TYS
2 stops35h 10m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/287:00 am
TYS
- SAN
1 stop29h 09m
Multiple Airlines
Sat 7/44:17 pm
SAN
- TYS
1 stop27h 39m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$317
One-way flights from Knoxville to San DiegoSearch for one-way flight options from Knoxville to San Diego. Find affordable one-way fares based on user searches. Data last updated May 9, 2026.
Search for one-way flight options from Knoxville to San Diego. Find affordable one-way fares based on user searches. Data last updated May 9, 2026.
This Mytrip deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:32 pm
TYS
- SAN
1 stop15h 37m
Frontier
Deal found 5/8![Frontier logo]()
$115
This CheapOair deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:32 pm
TYS
- SAN
1 stop15h 33m
Frontier
Deal found 5/5![Frontier logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:54 pm
TYS
- SAN
1 stop11h 04m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$125
This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:32 pm
TYS
- SAN
1 stop15h 37m
Frontier
Deal found 5/6![Frontier logo]()
$135
This CheapOair deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/268:32 pm
TYS
- SAN
1 stop15h 10m
Frontier
Deal found 5/9![Frontier logo]()
$136
This Booking.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:32 pm
TYS
- SAN
1 stop15h 33m
Frontier
Deal found 5/6![Frontier logo]()
$137
This Mytrip deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/258:19 pm
TYS
- SAN
1 stop15h 23m
Frontier
Deal found 5/7![Frontier logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/287:00 am
TYS
- SAN
1 stop29h 09m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:32 pm
TYS
- SAN
1 stop15h 37m
Frontier
Deal found 5/4![Frontier logo]()
$148
This Mytrip deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:32 pm
TYS
- SAN
1 stop15h 10m
Frontier
Deal found 5/8![Frontier logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/225:43 pm
TYS
- SAN
2 stops24h 49m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$161
Find flight deals from Knoxville to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $247 (Frontier) |
One-way from | $115 (Mytrip) |
Popular in | March |
Cheapest in | February |
Average price | $396 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 9, 2026.
Use the filters below to find and compare flights from Knoxville to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Wed 8/12
4:38 pm-11:00 pm
1 stop9h 22m
San Diego
Tue 8/18
1:58 pm-11:52 pm
1 stop6h 54m
$347
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Wed 6/3
7:51 am-2:20 pm
1 stop9h 29m
San Diego
Wed 6/10
6:15 am-6:02 pm
1 stop8h 47m
$368
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Wed 8/12
7:00 am-5:26 pm
2 stops13h 26m
San Diego
Tue 8/18
11:00 am-10:44 pm
1 stop8h 44m
$442
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Tue 6/2
12:50 pm-7:35 pm
1 stop9h 45m
San Diego
Tue 6/9
6:40 am-6:20 pm
2 stops8h 40m
$444
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Tue 8/11
6:30 am-5:26 pm
2 stops13h 56m
San Diego
Sat 8/15
6:55 pm-10:36 am
2 stops12h 41m
$457
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Tue 6/2
6:00 am-11:21 am
1 stop8h 21m
San Diego
Wed 6/3
7:41 pm-9:43 am
2 stops11h 02m
$462
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Wed 8/5
5:45 am-10:49 am
1 stop8h 04m
San Diego
Sat 8/8
8:42 pm-9:43 am
2 stops10h 01m
$497
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Wed 7/22
5:45 am-10:49 am
1 stop8h 04m
San Diego
Wed 7/22
9:59 pm-10:42 am
1 stop9h 43m
$502
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Fri 7/3
1:35 pm-8:23 pm
1 stop9h 48m
San Diego
Tue 7/7
8:32 pm-9:43 am
2 stops10h 11m
$502
Cheapest one-way
KnoxvilleSan Diego
TYS - SAN
TYSSAN
Knoxville McGhee Tyson
Wed 6/10
8:32 pm-9:09 am
1 stop15h 37m
$148
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Diego in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Knoxville-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Knoxville with our price prediction graph.
TYS-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Diego
Prices
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How far ahead should I book a flight from Knoxville to San Diego?
The best time to book flights from Knoxville to San Diego is 10 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Diego?
Currently, July is the cheapest month in which you can book a flight from Knoxville to San Diego (average of $288). Flying from Knoxville to San Diego in March is currently the most expensive (average of $512). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to San Diego?
What’s the top layover airport for flights from Knoxville to San Diego?
Share of 1-stop round-trip flights from Knoxville to San Diego chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 55% of 1-stop itineraries from Knoxville to San Diego on Cheapflights.
What’s the cheapest layover airport for flights from Knoxville to San Diego?
Average round-trip fare for 1-stop flights from Knoxville to San Diego, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $250.
What’s the fastest layover option from Knoxville to San Diego?
Shortest average travel time for 1-stop one-way flights from Knoxville to San Diego, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 6h 56m.
Which airport typically offers the quickest layover for flights from Knoxville to San Diego?
Average layover duration for 1-stop one-way flights from Knoxville to San Diego, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 54m.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated May 9, 2026.
Get a feel of what it's like to fly with Alaska Airlines,Delta, andUnited Airlines from Knoxville to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Entertainment
7.0
Overall
7.9
Comfort
7.8
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Crew
8.5
Entertainment
7.0
Overall
7.9
Comfort
7.8
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Crew
8.5
Entertainment
7.0
Overall
7.9
Comfort
7.8
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Crew
8.5
Entertainment
7.0
Overall
7.9
Comfort
7.8
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Crew
8.5
Entertainment
7.0
Overall
7.9
Comfort
7.8
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Crew
8.5
Entertainment
7.0
Overall
7.9
Comfort
7.8
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove
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Knoxville and San Diego flights
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Top 5 airlines flying from Knoxville to San Diego
Discover the top 5 airlines that operate flights from Knoxville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$125 | Average$250 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$218 | Average$436 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$250 | Average$389 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$276 | Average$409 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$276 | Average$459 | FlexibilityNo cancel fee | On-time71% |