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$114+ Cheap flights from Knoxville to Santa Ana (TYS - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty are usually found in February or April, booked 89 days in advance, depart on a Saturday or Friday and return on a Saturday

Cheap flight deals from Knoxville to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 3, 2025.

Round-trip from

$277
(Mytrip)

One-way from

$114
(Mytrip)

Popular in

October

Cheapest in

February

Average price

$458
From Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
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One-way flight from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
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Highest demand for flights based on searches. 14% potential increase in price ($68 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Knoxville to Santa Ana

Cheapest flights from Knoxville to Santa Ana
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This Mytrip deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/299:09 pmTYS - SNA
3 stops27h 12mMultiple Airlines
Thu 9/46:45 amSNA - TYS
2 stops13h 23mMultiple Airlines
Deal found 7/2$277
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/254:02 pmTYS - SNA
1 stop9h 01mDelta
Sat 8/912:00 pmSNA - TYS
1 stop8h 59mDelta
Deal found 7/2$289
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/65:30 amTYS - SNA
2 stops9h 27mAmerican Airlines
Sat 8/910:00 amSNA - TYS
2 stops9h 15mAmerican Airlines
Deal found 7/1$299
This Alaska Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/162:21 pmTYS - SNA
2 stops22h 33mAlaska Airlines
Tue 10/286:45 amSNA - TYS
2 stops14h 38mAlaska Airlines
Deal found 7/1$439
This United Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/244:40 pmTYS - SNA
1 stop6h 53mUnited Airlines
Sun 8/318:05 amSNA - TYS
1 stop8h 48mUnited Airlines
Deal found 7/3$444

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Knoxville

Fly to

Santa Ana

Route

Depart

Return

Price

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 8/29

9:09 pm-9:21 pm

3 stops27h 12m

Santa Ana J. Wayne/Orange Cnty

Thu 9/4

6:45 am-11:08 pm

2 stops13h 23m

$277

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 7/25

5:30 am-10:50 am

1 stop8h 20m

Santa Ana J. Wayne/Orange Cnty

Mon 8/11

2:00 pm-11:48 pm

1 stop6h 48m

$289

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 8/6

5:30 am-11:57 am

2 stops9h 27m

Santa Ana J. Wayne/Orange Cnty

Sat 8/9

10:00 am-10:15 pm

2 stops9h 15m

$299

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 8/24

4:40 pm-8:33 pm

1 stop6h 53m

Santa Ana J. Wayne/Orange Cnty

Sun 8/31

8:05 am-7:53 pm

1 stop8h 48m

$444

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 8/17

5:25 pm-11:10 am

1 stop20h 45m

$114

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 7/29

4:55 pm-9:21 pm

3 stops31h 26m

$157

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 8/2

5:30 am-10:21 am

1 stop7h 51m

$237

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 7/22

5:46 pm-10:17 pm

1 stop7h 31m

$315

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sat 7/19

12:14 pm-5:57 pm

2 stops8h 43m

$438

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 7/18

2:02 pm-10:18 pm

2 stops11h 16m

$545

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Santa Ana. Price data was last updated on June 27, 2025.

Booking 72 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Santa Ana?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana (average of $298). Flying from Knoxville to Santa Ana in March is currently the most expensive (average of $377). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SNA?

Find hourly flight availability from Knoxville to Santa Ana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

When flying from Knoxville to Santa Ana, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 19% versus a flight in the afternoon.

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated July 3, 2025.
Get a feel of what it's like to fly with Alaska Airlines, Delta, and United Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,982 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,861 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
5.9
Fair
3,286 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Entertainment

7.1

Comfort

7.8

Food

7.1

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Santa Ana round-trip?

    Flying on Delta is currently your cheapest option to Santa Ana, with prices starting at $289. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $299 and $444, respectively. You may be able to fly from Knoxville to Santa Ana for 29% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Knoxville to Santa Ana one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $114. Delta flights start at $237 while deals on United Airlines start at $315 one-way.

  • Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.

  • Can I find deals for business class flights from Knoxville to Santa Ana?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Ana?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana (average of $298). Flying from Knoxville to Santa Ana in March is currently the most expensive (average of $377). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

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Top 3 airlines flying from Knoxville to Santa Ana

Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$242Average$414FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$256Average$518FlexibilityNo cancel feeOn-time69%
DeltaCheapest$282Average$418FlexibilityNo cancel feeOn-timeN/A

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