HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Ana

$173+ Cheap flights from Knoxville to Santa Ana, CA (TYS - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Jun 25 — Jul 21
Thu 6/25
Thu 7/2
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Santa Ana with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Santa Ana

Cheapest flights from Knoxville to Santa Ana
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 26, 2026.

This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:30 am
TYS
-
SNA
1 stop8h 26m
American Airlines
Wed 9/239:03 am
SNA
-
TYS
1 stop7h 17m
American Airlines
Deal found 5/21$349
This Southwest deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/163:00 pm
TYS
-
SNA
1 stop8h 55m
Southwest
Wed 9/236:45 am
SNA
-
TYS
2 stops9h 10m
Southwest
Deal found 5/21$364
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:08 pm
TYS
-
SNA
1 stop7h 20m
Delta
Fri 7/102:00 pm
SNA
-
TYS
1 stop6h 52m
Delta
Deal found 5/25$403
This Booking.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:32 pm
TYS
-
SNA
1 stop15h 57m
Frontier
Mon 6/158:55 am
SNA
-
TYS
1 stop7h 42m
Frontier
Deal found 5/21$413
This Southwest deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:40 pm
TYS
-
SNA
1 stop7h 15m
Southwest
Tue 7/147:00 am
SNA
-
TYS
2 stops8h 20m
Southwest
Deal found 5/24$418
This Southwest deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/42:30 pm
TYS
-
SNA
2 stops7h 25m
Southwest
Mon 7/138:35 am
SNA
-
TYS
2 stops9h 40m
Southwest
Deal found 5/25$433
This Southwest deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/214:50 pm
TYS
-
SNA
2 stops8h 15m
Southwest
Mon 8/246:45 am
SNA
-
TYS
1 stop6h 10m
Southwest
Deal found 5/24$438
This Southwest deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:10 am
TYS
-
SNA
2 stops8h 35m
Southwest
Mon 7/67:00 am
SNA
-
TYS
1 stop9h 10m
Southwest
Deal found 5/24$453
This United Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:15 am
TYS
-
SNA
1 stop9h 47m
United Airlines
Sat 8/296:25 pm
SNA
-
TYS
2 stops13h 12m
United Airlines
Deal found 5/25$454

Find flight deals from Knoxville to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$349
(American Airlines)

One-way from

$173
(Kiwi.com)

Popular in

January

Cheapest in

September

Average price

$448
Provider with most accurate pricing for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flights.
Search Deals
From Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
One-way flight from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($64 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 26, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 8/17

4:50 pm-10:17 pm

1 stop8h 27m

Santa Ana J. Wayne/Orange Cnty

Thu 8/20

11:10 am-10:29 pm

1 stop8h 19m

$557

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 6/23

7:15 am-2:03 pm

1 stop9h 48m

Santa Ana J. Wayne/Orange Cnty

Tue 6/30

6:26 pm-10:42 am

2 stops13h 16m

$592

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 6/19

4:20 pm-10:20 pm

2 stops9h 00m

Santa Ana J. Wayne/Orange Cnty

Fri 6/26

8:35 am-9:10 pm

2 stops9h 35m

$605

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 6/28

6:00 am-9:07 am

2 stops30h 07m

Santa Ana J. Wayne/Orange Cnty

Sat 7/4

6:45 am-3:53 pm

1 stop6h 08m

$652
Cheapest one-way

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-12:15 pm

1 stop20h 46m

$173

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 8/26

6:03 am-10:50 am

1 stop7h 47m

$175

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 11/11

7:00 am-1:55 pm

2 stops9h 55m

$180

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 8/26

7:00 am-2:00 pm

2 stops10h 00m

$180

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 6/25

4:20 pm-10:25 pm

2 stops9h 05m

$234
Quickest one-way

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 6/26

4:20 pm-8:25 pm

1 stop7h 05m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/22

Sorted by cheapest first

Compare providers for flights from Knoxville to Santa Ana

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana, California flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana, California?

Booking 10 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana, California. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $378). Flying from Knoxville to Santa Ana, California in January is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Santa Ana, California?

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated May 26, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,425 reviews

Food

7.2

Boarding

8.1

Comfort

7.8

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,425 reviews
Delta
7.9
Good
8,425 reviews

Food

7.2

Boarding

8.1

Comfort

7.8

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
9,749 reviews
Delta
7.9
Good
8,425 reviews

Food

7.2

Boarding

8.1

Comfort

7.8

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.1
Good
11,629 reviews
Delta
7.9
Good
8,425 reviews

Food

7.2

Boarding

8.1

Comfort

7.8

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santa Ana, California?

    Departing from Knoxville to Santa Ana, California will take you 8h 27m. There are 1918 mi between Knoxville and Santa Ana, California. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Santa Ana, California round-trip?

    Currently priced at $274, Delta will fly you from Knoxville to Santa Ana, California and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $288 and $288, respectively. You may be able to fly from Knoxville to Santa Ana, California for 46% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.

  • Can I find deals for business class flights from Knoxville to Santa Ana?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $378). Flying from Knoxville to Santa Ana, California in January is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Tustin

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Santa Ana

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Las Vegas flights
Nashville to Los Angeles flights
Chattanooga to Las Vegas flights
Memphis to Las Vegas flights
Memphis to Los Angeles flights
Nashville to San Francisco flights
Nashville to San Diego flights
Nashville to Ontario flights
Nashville to Sacramento flights
Knoxville to Las Vegas flights
Memphis to San Diego flights
Nashville to Santa Ana flights
Knoxville to Los Angeles flights
Memphis to Ontario flights
Memphis to San Francisco flights
Chattanooga to San Francisco flights
Chattanooga to Los Angeles flights
Nashville to San Jose flights
Knoxville to San Francisco flights
Nashville to Burbank flights
Nashville to Reno flights
Chattanooga to San Diego flights
Knoxville to San Diego flights
Nashville to Medford flights
Nashville to Long Beach flights
Nashville to Fresno flights
Knoxville to Ontario flights
Knoxville to Reno flights
Memphis to Burbank flights
Nashville to Oakland flights
Chattanooga to Reno flights
Blountville to Las Vegas flights
Chattanooga to Sacramento flights
Blountville to San Francisco flights
Knoxville to Sacramento flights
Nashville to Monterey flights
Chattanooga to Ontario flights
Blountville to Fresno flights
Chattanooga to Santa Ana flights
Knoxville to Fresno flights
Memphis to Sacramento flights
Memphis to Santa Ana flights
Nashville to San Luis Obispo flights
Knoxville to San Jose flights
Knoxville to Santa Barbara flights
Chattanooga to Fresno flights
Memphis to Reno flights
Memphis to San Jose flights
Knoxville to Burbank flights

Top 3 airlines flying from Knoxville to Santa Ana

Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$274Average$398FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$288Average$498FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$288Average$497FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.