$189+ Cheap flights from Knoxville to Santa Ana, CA (TYS - SNA)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Nov 18 — Nov 251
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Santa Ana with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Santa Ana
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Best
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One-way
Cheapest flights from Knoxville to Santa AnaExplore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:30 am -
1 stop8h 33m
Mon 11/161:26 pm -
1 stop7h 06m
Deal found 10/15![American Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/29:42 pm -
1 stop20h 21m
Fri 11/67:30 am -
1 stop12h 05m
Deal found 10/18![Multiple Airlines logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:29 pm -
1 stop24h 42m
Thu 11/52:01 pm -
2 stops29h 34m
Deal found 10/16![Multiple Airlines logo]()
$401
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:30 am -
1 stop7h 16m
Thu 11/197:30 am -
1 stop26h 12m
Deal found 10/19![Multiple Airlines logo]()
$434
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:05 pm -
1 stop7h 14m
Sat 11/78:46 am -
2 stops10h 11m
Deal found 10/15![United Airlines logo]()
$436
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/53:40 pm -
2 stops9h 30m
Sat 11/77:00 am -
2 stops7h 45m
Deal found 10/15![Southwest logo]()
$478
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:52 am -
1 stop7h 13m
Sun 1/178:30 am -
1 stop8h 27m
Deal found 10/19![American Airlines logo]()
$487
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:55 am -
2 stops9h 15m
Wed 1/66:45 am -
1 stop6h 00m
Deal found 10/19![Southwest logo]()
$492
Best flights from Knoxville to Santa AnaDiscover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
Discover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/186:46 pm -
1 stop6h 44m
Sat 2/208:00 am -
1 stop6h 56m
Deal found 10/16![American Airlines logo]()
$417
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:55 am -
2 stops9h 15m
Wed 1/66:45 am -
1 stop6h 00m
Deal found 10/19![Southwest logo]()
$492
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:55 pm -
1 stop9h 33m
Mon 11/166:50 am -
1 stop6h 14m
Deal found 10/16![United Airlines logo]()
$537
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/182:40 pm -
2 stops9h 25m
Sat 2/206:45 am -
2 stops10h 55m
Deal found 10/16![Southwest logo]()
$531
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:45 am -
2 stops11h 41m
Mon 11/166:50 am -
1 stop6h 14m
Deal found 10/15![United Airlines logo]()
$542
This Southwest deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/225:35 pm -
1 stop7h 20m
Mon 12/286:45 am -
2 stops8h 55m
Deal found 10/17![Southwest logo]()
$542
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/511:53 am -
2 stops12h 16m
Sun 1/178:10 am -
1 stop7h 13m
Deal found 10/19![United Airlines logo]()
$549
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/305:30 am -
1 stop7h 34m
Tue 1/59:19 am -
1 stop9h 14m
Deal found 10/18![American Airlines logo]()
$607
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/182:20 pm -
1 stop8h 48m
Sat 2/206:28 pm -
2 stops12h 41m
Deal found 10/16![United Airlines logo]()
$560
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:00 am -
2 stops10h 14m
Tue 12/110:20 am -
1 stop7h 27m
Deal found 10/19![United Airlines logo]()
$612
Last-minute flights from Knoxville to Santa AnaDiscover last-minute flight deals from Knoxville to Santa Ana. Data last updated October 19, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santa Ana. Data last updated October 19, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:29 pm -
1 stop24h 42m
Thu 11/52:01 pm -
2 stops29h 34m
Deal found 10/16![Multiple Airlines logo]()
$401
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/13:43 pm -
1 stop9h 49m
Fri 11/61:26 pm -
1 stop7h 06m
Deal found 10/16![American Airlines logo]()
$522
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/29:42 pm -
1 stop20h 21m
Fri 11/67:30 am -
1 stop12h 05m
Deal found 10/18![Multiple Airlines logo]()
$384
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:45 am -
2 stops9h 29m
Sat 11/76:45 am -
1 stop7h 14m
Deal found 10/15![United Airlines logo]()
$527
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:05 am -
2 stops8h 10m
Sat 11/77:00 am -
2 stops7h 45m
Deal found 10/15![Southwest logo]()
$532
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:05 pm -
1 stop7h 14m
Sat 11/78:46 am -
2 stops10h 11m
Deal found 10/15![United Airlines logo]()
$436
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/53:40 pm -
2 stops9h 30m
Sat 11/77:00 am -
2 stops7h 45m
Deal found 10/15![Southwest logo]()
$478
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:30 am -
1 stop8h 33m
Mon 11/161:26 pm -
1 stop7h 06m
Deal found 10/15![American Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:30 am -
1 stop7h 16m
Thu 11/197:30 am -
1 stop26h 12m
Deal found 10/19![Multiple Airlines logo]()
$434
This Southwest deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:20 pm -
1 stop6h 40m
Sat 11/219:05 pm -
2 stops12h 05m
Deal found 10/17![Southwest logo]()
$528
One-way flights from Knoxville to Santa AnaSearch for one-way flight options from Knoxville to Santa Ana. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
Search for one-way flight options from Knoxville to Santa Ana. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:29 pm -
1 stop8h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:20 am -
1 stop7h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop7h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/39:00 pm -
3 stops21h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Multiple Airlines logo]()
$236
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/215:30 am -
1 stop7h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![American Airlines logo]()
$244
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/242:40 pm -
2 stops9h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Southwest logo]()
$249
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:00 am -
2 stops8h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Southwest logo]()
$269
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/235:35 pm -
1 stop7h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Southwest logo]()
$282
Find flight deals from Knoxville to Santa Ana
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $363 (American Airlines) |
One-way from | $189 (Kiwi.com) |
Popular in | January |
Cheapest in | May |
Average price | $653 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Sun 11/22
6:20 am-10:57 am
1 stop7h 37m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$224
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Thu 10/29
6:30 am-10:46 am
1 stop7h 16m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$231
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Wed 12/23
5:35 pm-9:55 pm
1 stop7h 20m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$282
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Mon 12/21
7:00 am-12:35 pm
2 stops8h 35m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$287
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Fri 11/13
2:38 pm-1:17 pm
3 stops49h 39m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$291
Quickest round-trip
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Sun 11/22
5:05 pm-9:19 pm
1 stop7h 14m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$327
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Tue 12/22
3:45 pm-10:15 pm
2 stops9h 30m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$336
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Fri 2/12
3:30 pm-9:15 am
1 stop20h 45m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$376
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Thu 2/18
6:46 pm-10:30 pm
1 stop6h 44m
Santa Ana J. Wayne/Orange Cnty
Sat 2/20
8:00 am-5:56 pm
1 stop6h 56m
$417
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Wed 12/30
6:55 am-1:10 pm
2 stops9h 15m
Santa Ana J. Wayne/Orange Cnty
Wed 1/6
6:45 am-3:45 pm
1 stop6h 00m
$492
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Santa Ana
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana, California flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santa Ana
Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
TYS-SNA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Santa Ana
What is the cheapest month to book a flight from Knoxville to Santa Ana, California?
Currently, May is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $448). Flying from Knoxville to Santa Ana, California in January is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Santa Ana, California?
Airfare is below average for this route at the moment.
Knoxville to Santa Ana, California flights typically cost between $524 and $816 in November.The cheapest round-trip price found within the last 5 days was $363 on American Airlines (Nov 12-Nov 16).
Reviews of airlines servicing Santa Ana
Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated October 19, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Overall
7.9
Entertainment
7.4
Crew
8.6
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Overall
7.9
Entertainment
7.4
Crew
8.6
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Overall
7.9
Entertainment
7.4
Crew
8.6
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Overall
7.9
Entertainment
7.4
Crew
8.6
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Overall
7.9
Entertainment
7.4
Crew
8.6
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Book flights to Santa Ana if you plan to visit one of these locationsTustin
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Knoxville and Santa Ana flights
Browse other Knoxville and Santa Ana flight options. Last updated on October 19, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on October 19, 2026.
Popular flight searches
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Other flights to Santa Ana
Explore flights to Santa Ana departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 19, 2026.
Top 4 airlines flying from Knoxville to Santa Ana
Discover the top 4 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$457 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$524 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$356 | Average$596 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$378 | Average$593 | FlexibilityNo cancel fee | On-time63% |