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Santa Ana

$146+ Cheap flights from Knoxville to Santa Ana, CA (TYS - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Aug 24 — Aug 311
Mon 8/24
Mon 8/31
1 adult, Economy
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Cheap flight deals from Knoxville to Santa Ana

Cheapest flights from Knoxville to Santa Ana
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 25, 2026.

This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:39 pm
TYS
-
SNA
1 stop26h 03m
Multiple Airlines
Mon 8/247:30 am
SNA
-
TYS
1 stop11h 16m
Multiple Airlines
Deal found 7/21$307
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:29 pm
TYS
-
SNA
1 stop20h 46m
Multiple Airlines
Mon 8/247:30 am
SNA
-
TYS
1 stop11h 16m
Multiple Airlines
Deal found 7/21$333
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:03 am
TYS
-
SNA
1 stop6h 39m
American Airlines
Sat 8/221:34 pm
SNA
-
TYS
1 stop6h 44m
American Airlines
Deal found 7/22$355
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:02 pm
TYS
-
SNA
1 stop7h 23m
United Airlines
Tue 8/2511:10 am
SNA
-
TYS
2 stops9h 49m
United Airlines
Deal found 7/21$360
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:03 am
TYS
-
SNA
1 stop6h 39m
American Airlines
Mon 8/241:34 pm
SNA
-
TYS
1 stop6h 44m
American Airlines
Deal found 7/24$363
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/181:55 pm
TYS
-
SNA
2 stops8h 20m
Southwest
Tue 8/256:45 am
SNA
-
TYS
2 stops9h 10m
Southwest
Deal found 7/21$366
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/244:38 pm
TYS
-
SNA
1 stop8h 18m
Delta
Wed 9/96:45 am
SNA
-
TYS
1 stop6h 58m
Delta
Deal found 7/20$367
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:50 pm
TYS
-
SNA
2 stops8h 20m
Southwest
Mon 8/248:45 pm
SNA
-
TYS
2 stops12h 20m
Southwest
Deal found 7/21$371
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:00 am
TYS
-
SNA
1 stop10h 32m
Multiple Airlines
Sun 10/183:07 pm
SNA
-
TYS
1 stop21h 31m
Multiple Airlines
Deal found 7/21$372
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:50 pm
TYS
-
SNA
1 stop8h 05m
Southwest
Mon 9/147:45 pm
SNA
-
TYS
2 stops13h 20m
Southwest
Deal found 7/24$375

Find flight deals from Knoxville to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$307
(Kiwi.com)

One-way from

$146
(Kiwi.com)

Popular in

January

Cheapest in

May

Average price

$533
Provider with most accurate pricing for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flights.
Search Deals
From Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
One-way flight from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($62 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 10/14

4:20 pm-9:50 pm

2 stops8h 30m

Santa Ana J. Wayne/Orange Cnty

Sun 10/18

9:35 am-10:40 pm

2 stops10h 05m

$428

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 11/12

3:55 pm-10:29 pm

1 stop9h 34m

Santa Ana J. Wayne/Orange Cnty

Mon 11/16

2:00 pm-11:46 pm

1 stop6h 46m

$428

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 9/16

3:00 pm-8:55 pm

1 stop8h 55m

Santa Ana J. Wayne/Orange Cnty

Sun 9/20

8:45 pm-1:25 pm

2 stops13h 40m

$429

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 9/14

6:02 pm-10:25 pm

1 stop7h 23m

Santa Ana J. Wayne/Orange Cnty

Wed 9/16

6:45 am-11:59 pm

2 stops14h 14m

$510

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 9/10

6:02 pm-10:25 pm

1 stop7h 23m

Santa Ana J. Wayne/Orange Cnty

Mon 9/14

6:32 pm-9:58 am

2 stops12h 26m

$510
Quickest round-trip

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 8/14

7:15 am-11:02 am

1 stop6h 47m

Santa Ana J. Wayne/Orange Cnty

Mon 8/17

1:08 pm-10:29 pm

1 stop6h 21m

$529

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 9/16

4:50 pm-10:17 pm

1 stop8h 27m

Santa Ana J. Wayne/Orange Cnty

Sun 9/20

6:32 pm-9:58 am

2 stops12h 26m

$546

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 8/16

4:50 pm-10:17 pm

1 stop8h 27m

Santa Ana J. Wayne/Orange Cnty

Thu 8/20

6:45 am-9:45 pm

2 stops12h 00m

$546
Cheapest one-way

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 11/11

5:01 pm-9:01 pm

1 stop7h 00m

$178

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 9/9

4:50 pm-8:44 pm

1 stop6h 54m

$182

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/21

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Santa Ana

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
BudgetAirPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana, California flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana, California?

Booking 10 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana, California. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $338). Flying from Knoxville to Santa Ana, California in January is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Santa Ana, California?

Airfare is below average for this route at the moment.

Knoxville to Santa Ana, California flights typically cost between $397 and $602 in August.
The cheapest round-trip price found within the last 5 days was $307 on Multiple Airlines (Aug 20-Aug 24).

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated July 25, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,233 reviews

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Walter,May 2026

LAS - BUR

Short but excellent flight. Everyone was friendly and professional it was a great flight!
Southwest
8.0
Very good
4,233 reviews
Southwest
8.0
Very good
4,233 reviews

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Walter,May 2026

LAS - BUR

Short but excellent flight. Everyone was friendly and professional it was a great flight!
Delta
7.8
Good
8,486 reviews
Southwest
8.0
Very good
4,233 reviews

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Walter,May 2026

LAS - BUR

Short but excellent flight. Everyone was friendly and professional it was a great flight!
United Airlines
7.4
Good
10,034 reviews
Southwest
8.0
Very good
4,233 reviews

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Walter,May 2026

LAS - BUR

Short but excellent flight. Everyone was friendly and professional it was a great flight!
American Airlines
7.1
Good
11,848 reviews
Southwest
8.0
Very good
4,233 reviews

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Walter,May 2026

LAS - BUR

Short but excellent flight. Everyone was friendly and professional it was a great flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santa Ana, California?

    Departing from Knoxville to Santa Ana, California will take you 7h 23m. There are 1918 mi between Knoxville and Santa Ana, California. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Santa Ana, California round-trip?

    Currently priced at $228, Delta will fly you from Knoxville to Santa Ana, California and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $288 and $288, respectively. You may be able to fly from Knoxville to Santa Ana, California for 58% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Knoxville to Santa Ana, California one-way?

    The cheapest airlines for a one-way flight from Knoxville to Santa Ana, California are American Airlines ($174), United Airlines ($188), and Delta ($269).

  • Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.

  • Can I find deals for business class flights from Knoxville to Santa Ana?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $338). Flying from Knoxville to Santa Ana, California in January is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Tustin

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Top 4 airlines flying from Knoxville to Santa Ana

Discover the top 4 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$228Average$398FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$288Average$498FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$288Average$567FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$378Average$593FlexibilityNo cancel feeOn-time63%

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