$97+ Cheap flights from Knoxville to San Francisco (TYS - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Nov 2 — Nov 91
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to San Francisco
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Cheapest flights from Knoxville to San FranciscoExplore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 3, 2026.
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop20h 50m
Tue 11/311:52 pm -
2 stops32h 46m
Deal found 9/30![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:29 pm -
1 stop13h 44m
Tue 10/2711:52 pm -
2 stops32h 37m
Deal found 9/30![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:29 pm -
1 stop13h 44m
Wed 10/287:14 pm -
1 stop22h 25m
Deal found 10/2![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
2 stops10h 06m
Thu 11/52:21 pm -
1 stop29h 14m
Deal found 9/30![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1610:09 pm -
1 stop13h 10m
Sat 11/219:23 pm -
1 stop12h 49m
Deal found 9/30![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:29 pm -
1 stop13h 44m
Sun 10/2510:19 pm -
2 stops17h 36m
Deal found 9/30![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:59 pm -
1 stop13h 14m
Thu 10/222:17 pm -
2 stops24h 20m
Deal found 9/30![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:49 pm -
1 stop28h 31m
Sun 11/110:23 pm -
1 stop19h 29m
Deal found 10/1![Multiple Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop20h 50m
Mon 11/210:17 pm -
2 stops32h 48m
Deal found 10/1![Multiple Airlines logo]()
$338
Best flights from Knoxville to San FranciscoDiscover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 3, 2026.
Discover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 3, 2026.
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:10 am -
1 stop10h 16m
Tue 11/176:00 am -
1 stop6h 15m
Deal found 10/1![Delta logo]()
$377
This Southwest deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:10 am -
2 stops10h 20m
Tue 11/176:10 am -
2 stops10h 40m
Deal found 10/1![Southwest logo]()
$387
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:09 am -
1 stop7h 11m
Thu 11/126:00 am -
1 stop6h 15m
Deal found 9/29![Delta logo]()
$377
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/277:00 am -
2 stops9h 55m
Thu 2/46:35 am -
1 stop6h 10m
Deal found 10/2![Southwest logo]()
$426
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:10 pm -
1 stop8h 48m
Sun 11/156:00 am -
1 stop8h 22m
Deal found 9/29![Delta logo]()
$422
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:05 am -
2 stops9h 55m
Sun 12/138:00 am -
1 stop7h 45m
Deal found 9/28![Southwest logo]()
$427
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:30 pm -
2 stops10h 15m
Mon 11/25:05 am -
2 stops10h 40m
Deal found 10/2![Southwest logo]()
$468
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:40 am -
2 stops10h 35m
Wed 11/186:00 am -
1 stop6h 15m
Deal found 9/30![Delta logo]()
$469
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/117:05 am -
2 stops10h 20m
Sun 12/136:50 am -
2 stops10h 40m
Deal found 10/2![Southwest logo]()
$473
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:35 pm -
2 stops9h 55m
Mon 11/309:00 am -
2 stops10h 40m
Deal found 10/2![Southwest logo]()
$538
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:15 pm -
2 stops8h 15m
Fri 12/46:10 am -
1 stop6h 20m
Deal found 9/29![Southwest logo]()
$553
Last-minute flights from Knoxville to San FranciscoDiscover last-minute flight deals from Knoxville to San Francisco. Data last updated October 3, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Francisco. Data last updated October 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:59 pm -
1 stop13h 14m
Thu 10/222:17 pm -
2 stops24h 20m
Deal found 9/30![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:29 pm -
1 stop13h 44m
Tue 10/2711:52 pm -
2 stops32h 37m
Deal found 9/30![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:29 pm -
1 stop13h 44m
Wed 10/287:14 pm -
1 stop22h 25m
Deal found 10/2![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:29 pm -
1 stop13h 44m
Sun 10/2510:19 pm -
2 stops17h 36m
Deal found 9/30![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop20h 50m
Tue 11/311:52 pm -
2 stops32h 46m
Deal found 9/30![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
2 stops10h 06m
Thu 11/52:21 pm -
1 stop29h 14m
Deal found 9/30![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop20h 50m
Mon 11/210:17 pm -
2 stops32h 48m
Deal found 10/1![Multiple Airlines logo]()
$338
This Kiwi.com deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:49 pm -
1 stop28h 31m
Sun 11/110:23 pm -
1 stop19h 29m
Deal found 10/1![Multiple Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1610:09 pm -
1 stop13h 10m
Sat 11/219:23 pm -
1 stop12h 49m
Deal found 9/30![Multiple Airlines logo]()
$281
One-way flights from Knoxville to San FranciscoSearch for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 3, 2026.
Search for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop20h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Multiple Airlines logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:29 pm -
1 stop13h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:42 pm -
1 stop23h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Multiple Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 pm -
2 stops29h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Multiple Airlines logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:00 am -
3 stops53h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Multiple Airlines logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:59 pm -
1 stop13h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Multiple Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:49 pm -
1 stop22h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$142
Find flight deals from Knoxville to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $239 (Kiwi.com) |
One-way from | $97 (Kiwi.com) |
Popular in | June |
Cheapest in | February |
Average price | $433 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 3, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Sun 10/25
9:29 pm-5:07 pm
1 stop22h 38m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$183
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Sat 10/24
10:42 am-5:20 pm
1 stop9h 38m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$184
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Sat 10/24
6:23 pm-10:59 pm
1 stop7h 36m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$189
Quickest round-trip
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Tue 10/27
6:23 pm-10:40 pm
1 stop7h 17m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$189
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Wed 12/9
6:25 am-11:36 am
1 stop8h 11m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$189
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Thu 12/10
7:10 am-2:33 pm
1 stop10h 23m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$189
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Tue 10/20
1:55 pm-7:32 pm
1 stop8h 37m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$189
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Wed 10/21
7:09 am-12:34 pm
1 stop8h 25m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$189
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Sat 10/17
6:00 am-11:25 am
1 stop8h 25m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$192
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Sat 3/13
5:30 am-11:59 am
1 stop9h 29m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$192
Showing 1-10 of 23 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Francisco in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Knoxville-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
TYS-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Francisco
Prices
More
How far ahead should I book a flight from Knoxville to San Francisco?
The best time to book flights from Knoxville to San Francisco is 67 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $329). Flying from Knoxville to San Francisco in June is currently the most expensive (average of $702). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to San Francisco?
Airfare is below average for this route at the moment.
Knoxville to San Francisco flights typically cost between $328 and $552 in October.The cheapest round-trip price found within the last 5 days was $239 on Multiple Airlines (Oct 29-Nov 3).
What’s the top layover airport for flights from Knoxville to San Francisco?
Share of 1-stop round-trip flights from Knoxville to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Dallas (DFW) – chosen by Cheapflights users on 67% of 1-stop itineraries from Knoxville to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Knoxville to San Francisco?
Average round-trip fare for 1-stop flights from Knoxville to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Houston (IAH) is the most affordable 1-stop option, with an average round-trip price of $400.
What’s the fastest layover option from Knoxville to San Francisco?
Shortest average travel time for 1-stop one-way flights from Knoxville to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Dallas (DFW) have the shortest average one-way travel time for 1-stop routes: 7h 12m.
Which airport typically offers the quickest layover for flights from Knoxville to San Francisco?
Average layover duration for 1-stop one-way flights from Knoxville to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Houston (IAH) offer the fastest connection on this route, with an average layover time of 1h 11m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 3, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andJetBlue from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Overall
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.8
Overall
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.8
Overall
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.8
Overall
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.8
Overall
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.8
Overall
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Knoxville and San Francisco flights
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Top 5 airlines flying from Knoxville to San Francisco
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$131 | Average$231 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$317 | Average$586 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$325 | Average$509 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$326 | Average$494 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$328 | Average$483 | FlexibilityNo cancel fee | On-timeN/A |