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$92+ Cheap flights from Knoxville to San Francisco (TYS - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Francisco are usually found in September or January, booked 89 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from Knoxville to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 3, 2025.

Round-trip from

$178
(Priceline)

One-way from

$92
(Priceline)

Popular in

December

Cheapest in

September

Average price

$420
From Knoxville McGhee Tyson to San Francisco
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One-way flight from Knoxville McGhee Tyson to San Francisco
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Highest demand for flights based on searches. 1% potential increase in price ($5 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Knoxville to San Francisco

Cheapest flights from Knoxville to San Francisco
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This Priceline deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/257:10 pmTYS - SFO
1 stop8h 09mFrontier
Sun 8/319:21 amSFO - TYS
1 stop7h 20mFrontier
Deal found 6/30$178
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/311:54 amTYS - SFO
1 stop9h 58mDelta
Sat 9/67:00 amSFO - TYS
1 stop8h 22mDelta
Deal found 7/2$309
This Trip.com deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/12:28 pmTYS - SFO
1 stop9h 53mMultiple Airlines
Sun 8/310:33 amSFO - TYS
1 stop24h 05mMultiple Airlines
Deal found 7/3$328
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/212:02 pmTYS - SFO
1 stop9h 53mAmerican Airlines
Sat 7/265:41 amSFO - TYS
1 stop8h 51mAmerican Airlines
Deal found 7/3$394
This United Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/37:20 amTYS - SFO
1 stop7h 59mUnited Airlines
Fri 9/512:43 amSFO - TYS
1 stop9h 55mUnited Airlines
Deal found 7/3$409

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Knoxville

Fly to

San Francisco

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 8/25

7:10 pm-12:19 am

1 stop8h 09m

San Francisco

Sun 8/31

9:21 am-7:41 pm

1 stop7h 20m

$178

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 9/3

11:54 am-6:52 pm

1 stop9h 58m

San Francisco

Sat 9/6

7:00 am-6:22 pm

1 stop8h 22m

$309

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Fri 8/1

2:28 pm-9:21 pm

1 stop9h 53m

San Francisco

Sun 8/3

10:33 am-1:38 pm

1 stop24h 05m

$328

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Mon 7/21

2:02 pm-8:55 pm

1 stop9h 53m

San Francisco

Sat 7/26

5:41 am-5:32 pm

1 stop8h 51m

$394

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 9/3

7:20 am-12:19 pm

1 stop7h 59m

San Francisco

Fri 9/5

12:43 am-1:38 pm

1 stop9h 55m

$409

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sun 8/17

5:25 pm-12:19 am

1 stop9h 54m

$92

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Thu 8/14

7:16 pm-12:35 am

1 stop8h 19m

$155

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 8/13

5:00 pm-10:01 pm

1 stop8h 01m

$205

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Wed 8/13

4:15 pm-4:56 pm

3 stops27h 41m

$218

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

Sun 7/27

12:14 pm-5:52 pm

1 stop8h 38m

$487

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Best time to book a flight from Knoxville to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Francisco

How far ahead should I book a flight from Knoxville to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Francisco. Price data was last updated on June 27, 2025.

The best time to book flights from Knoxville to San Francisco is 89 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $276). Flying from Knoxville to San Francisco in June is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SFO?

Find hourly flight availability from Knoxville to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

One of the essential ways to save on airfare from Knoxville to San Francisco is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 30% on airfare.

What is the cheapest day to fly from Knoxville to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to San Francisco. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to San Francisco flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated July 3, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,861 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
5.9
Fair
3,286 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to San Francisco round-trip?

    Flying on Frontier is currently your cheapest option to San Francisco, with prices starting at $178. Additional round-trip tickets that might be worth considering are offered by Delta and United Airlines, with the lowest prices starting at $309 and $409, respectively. Frontier is priced at 57% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Knoxville to San Francisco one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $92. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Knoxville to San Francisco for a low price.

  • Can I find deals for flights from Knoxville to San Francisco that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Francisco.

  • Can I find deals for business class flights from Knoxville to San Francisco?

    Yes. Cheapflights offers flight deals from Knoxville to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $276). Flying from Knoxville to San Francisco in June is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Roseville
Mountain View
South San Francisco
Livermore
Santa Cruz
Turlock
Manteca
Watsonville
Antioch
Hollister
Newark
Alameda
Hayward
Milpitas
Sunnyvale
Daly City
Campbell
Foster City
Capitola
Richmond

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Top 4 airlines flying from Knoxville to San Francisco

Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$155Average$188FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$248Average$520FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$308Average$419FlexibilityNo cancel feeOn-time71%
DeltaCheapest$308Average$420FlexibilityNo cancel feeOn-timeN/A

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