$164+ Cheap flights from Knoxville to San Francisco (TYS - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Sep 20 — Sep 271
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to San Francisco
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Best
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Cheapest flights from Knoxville to San FranciscoExplore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/158:55 am -
1 stop9h 54m
Tue 9/2211:37 am -
1 stop7h 07m
Deal found 8/20![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:00 am -
2 stops9h 15m
Sat 9/2611:05 pm -
1 stop8h 50m
Deal found 8/19![Southwest logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2612:04 pm -
2 stops34h 43m
Wed 11/44:00 pm -
1 stop25h 43m
Deal found 8/16![Multiple Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am -
1 stop8h 55m
Sat 9/512:25 pm -
1 stop7h 35m
Deal found 8/19![Delta logo]()
$363
This Southwest deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:55 pm -
2 stops10h 15m
Mon 9/2111:40 pm -
2 stops9h 25m
Deal found 8/20![Southwest logo]()
$368
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:00 am -
1 stop7h 30m
Mon 10/1211:30 pm -
1 stop7h 15m
Deal found 8/17![United Airlines logo]()
$370
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/254:50 pm -
2 stops9h 40m
Mon 9/2811:40 pm -
2 stops9h 25m
Deal found 8/18![Southwest logo]()
$373
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/208:20 am -
1 stop26h 54m
Fri 9/2510:05 pm -
2 stops11h 59m
Deal found 8/19![Multiple Airlines logo]()
$378
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop7h 30m
Sat 10/1011:30 pm -
1 stop7h 15m
Deal found 8/16![United Airlines logo]()
$383
Best flights from Knoxville to San FranciscoDiscover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
Discover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/287:55 am -
1 stop7h 36m
Wed 2/39:30 pm -
1 stop8h 42m
Deal found 8/16![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:55 am -
1 stop8h 55m
Sat 11/145:00 am -
2 stops9h 40m
Deal found 8/19![Southwest logo]()
$397
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:20 pm -
1 stop8h 39m
Wed 9/165:00 am -
1 stop8h 58m
Deal found 8/19![United Airlines logo]()
$468
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/114:00 pm -
1 stop8h 35m
Thu 2/46:00 am -
1 stop9h 13m
Deal found 8/20![Delta logo]()
$388
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:30 pm -
2 stops10h 05m
Sun 10/2511:40 pm -
2 stops9h 35m
Deal found 8/16![Southwest logo]()
$412
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:40 am -
2 stops10h 33m
Tue 9/2211:37 am -
1 stop7h 07m
Deal found 8/20![Delta logo]()
$405
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/254:50 pm -
2 stops9h 40m
Sun 9/277:50 pm -
2 stops14h 35m
Deal found 8/17![Southwest logo]()
$444
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2912:00 pm -
1 stop8h 11m
Thu 2/410:31 am -
2 stops9h 31m
Deal found 8/20![Delta logo]()
$431
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:25 pm -
1 stop7h 32m
Sat 10/1010:45 pm -
1 stop8h 32m
Deal found 8/18![Delta logo]()
$448
Last-minute flights from Knoxville to San FranciscoDiscover last-minute flight deals from Knoxville to San Francisco. Data last updated August 21, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Francisco. Data last updated August 21, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am -
1 stop8h 55m
Sat 9/512:25 pm -
1 stop7h 35m
Deal found 8/19![Delta logo]()
$363
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/158:55 am -
1 stop9h 54m
Tue 9/2211:37 am -
1 stop7h 07m
Deal found 8/20![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:55 pm -
2 stops10h 15m
Mon 9/2111:40 pm -
2 stops9h 25m
Deal found 8/20![Southwest logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/208:20 am -
1 stop26h 54m
Fri 9/2510:05 pm -
2 stops11h 59m
Deal found 8/19![Multiple Airlines logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:30 am -
1 stop9h 49m
Thu 9/246:04 am -
2 stops12h 52m
Deal found 8/16![Multiple Airlines logo]()
$393
This Southwest deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:00 am -
2 stops9h 15m
Sat 9/2611:05 pm -
1 stop8h 50m
Deal found 8/19![Southwest logo]()
$342
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/254:50 pm -
2 stops9h 40m
Mon 9/2811:40 pm -
2 stops9h 25m
Deal found 8/18![Southwest logo]()
$373
One-way flights from Knoxville to San FranciscoSearch for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.
Search for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2610:42 am -
1 stop9h 38m
Deal found 8/16![United Airlines logo]()
$164
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:25 pm -
1 stop8h 34m
Deal found 8/17![United Airlines logo]()
$169
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:00 am -
2 stops10h 40m
Deal found 8/17![Southwest logo]()
$174
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:00 am -
1 stop9h 14m
Deal found 8/17![United Airlines logo]()
$182
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:00 am -
2 stops8h 35m
Deal found 8/17![Southwest logo]()
$187
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:20 pm -
1 stop9h 37m
Deal found 8/18![Delta logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
3 stops42h 12m
Deal found 8/19![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:13 pm -
2 stops16h 01m
Deal found 8/18![Multiple Airlines logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:58 pm -
3 stops55h 17m
Deal found 8/19![Multiple Airlines logo]()
$201
Find flight deals from Knoxville to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $337 (Delta) |
One-way from | $164 (United Airlines) |
Popular in | June |
Cheapest in | February |
Average price | $435 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 21, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Thu 1/28
7:55 am-12:31 pm
1 stop7h 36m
San Francisco
Wed 2/3
9:30 pm-9:12 am
1 stop8h 42m
$337
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Mon 1/11
4:00 pm-9:35 pm
1 stop8h 35m
San Francisco
Thu 2/4
6:00 am-6:13 pm
1 stop9h 13m
$388
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Tue 11/10
7:55 am-1:50 pm
1 stop8h 55m
San Francisco
Sat 11/14
5:00 am-5:40 pm
2 stops9h 40m
$397
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Tue 9/15
5:40 am-1:13 pm
2 stops10h 33m
San Francisco
Tue 9/22
11:37 am-9:44 pm
1 stop7h 07m
$405
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Thu 10/22
5:30 pm-12:35 am
2 stops10h 05m
San Francisco
Sun 10/25
11:40 pm-12:15 pm
2 stops9h 35m
$412
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Fri 1/29
12:00 pm-5:11 pm
1 stop8h 11m
San Francisco
Thu 2/4
10:31 am-11:02 pm
2 stops9h 31m
$431
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Fri 9/25
4:50 pm-11:30 pm
2 stops9h 40m
San Francisco
Sun 9/27
7:50 pm-1:25 pm
2 stops14h 35m
$444
Quickest round-trip
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Mon 10/5
7:25 pm-11:57 pm
1 stop7h 32m
San Francisco
Sat 10/10
10:45 pm-10:17 am
1 stop8h 32m
$448
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Mon 9/14
7:20 pm-12:59 am
1 stop8h 39m
San Francisco
Wed 9/16
5:00 am-4:58 pm
1 stop8h 58m
$468
Cheapest one-way
KnoxvilleSan Francisco
TYS Knoxville McGhee Tyson - SFO San Francisco
TYSSFO
Knoxville McGhee Tyson
Wed 10/21
6:23 pm-11:56 pm
1 stop8h 33m
$169
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Francisco in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Knoxville-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
TYS-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Francisco
How far ahead should I book a flight from Knoxville to San Francisco?
The best time to book flights from Knoxville to San Francisco is 26 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $329). Flying from Knoxville to San Francisco in June is currently the most expensive (average of $702). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to San Francisco?
Airfare is below average for this route at the moment.
Knoxville to San Francisco flights typically cost between $395 and $598 in September.The cheapest round-trip price found within the last 5 days was $337 on Delta (Sep 15-Sep 22).
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated August 21, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Crew
8.5
Entertainment
7.8
Comfort
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Crew
8.5
Entertainment
7.8
Comfort
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Crew
8.5
Entertainment
7.8
Comfort
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Crew
8.5
Entertainment
7.8
Comfort
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Crew
8.5
Entertainment
7.8
Comfort
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
San Bruno
Emeryville
Roseville
Burlingame
Rancho Cordova
Fairfield
Vallejo
Cupertino
Newark
Hayward
San Ramon
Redwood City
Manteca
San Carlos
Turlock
San Lorenzo
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Knoxville and San Francisco flights
Browse other Knoxville and San Francisco flight options. Last updated on August 21, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on August 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 21, 2026.
Top 4 airlines flying from Knoxville to San Francisco
Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$131 | Average$254 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$325 | Average$503 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$328 | Average$494 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$353 | Average$506 | FlexibilityNo cancel fee | On-timeN/A |