$116+ Cheap flights from Knoxville to San Francisco (TYS - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Apr 15 — Apr 221
Round-trip
1 adult, Economy
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Best
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Cheapest flights from Knoxville to San FranciscoExplore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.
This Frontier deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SFO
1 stop11h 03m
Frontier
Mon 4/136:00 am
SFO
- TYS
1 stop6h 28m
Frontier
Deal found 3/11![Frontier logo]()
$245
This CheapOair deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:32 pm
TYS
- SFO
1 stop18h 10m
Frontier
Mon 5/116:00 am
SFO
- TYS
1 stop10h 33m
Frontier
Deal found 3/14![Frontier logo]()
$252
This Frontier deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SFO
1 stop11h 03m
Frontier
Sun 4/129:00 pm
SFO
- TYS
1 stop15h 28m
Frontier
Deal found 3/13![Frontier logo]()
$266
This Expedia deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:28 pm
TYS
- SFO
1 stop19h 45m
Frontier
Sun 4/196:00 am
SFO
- TYS
1 stop6h 33m
Frontier
Deal found 3/13![Frontier logo]()
$285
This CheapOair deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:32 pm
TYS
- SFO
1 stop14h 29m
Frontier
Mon 5/256:00 am
SFO
- TYS
1 stop10h 33m
Frontier
Deal found 3/11![Frontier logo]()
$301
This Frontier deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SFO
1 stop11h 03m
Frontier
Thu 4/166:00 am
SFO
- TYS
1 stop6h 33m
Frontier
Deal found 3/11![Frontier logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:39 pm
TYS
- SFO
1 stop9h 25m
Multiple Airlines
Sat 9/59:58 pm
SFO
- TYS
1 stop21h 55m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$336
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:24 pm
TYS
- SFO
1 stop8h 12m
Delta
Wed 4/155:50 am
SFO
- TYS
1 stop7h 52m
Delta
Deal found 3/11![Delta logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:30 am
TYS
- SFO
2 stops26h 18m
Multiple Airlines
Sun 4/129:00 pm
SFO
- TYS
1 stop15h 28m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$350
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:15 pm
TYS
- SFO
2 stops30h 15m
Multiple Airlines
Mon 5/1111:36 am
SFO
- TYS
1 stop8h 15m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$353
Best flights from Knoxville to San FranciscoDiscover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 16, 2026.
Discover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 16, 2026.
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:24 pm
TYS
- SFO
1 stop8h 12m
Delta
Mon 4/1310:55 pm
SFO
- TYS
1 stop8h 26m
Delta
Deal found 3/11![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:15 am
TYS
- SFO
2 stops14h 40m
Southwest
Tue 6/96:00 am
SFO
- TYS
2 stops11h 20m
Southwest
Deal found 3/12![Southwest logo]()
$450
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:20 pm
TYS
- SFO
1 stop8h 57m
United Airlines
Sat 4/1810:50 am
SFO
- TYS
1 stop9h 51m
United Airlines
Deal found 3/11![United Airlines logo]()
$459
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:05 am
TYS
- SFO
2 stops11h 15m
Southwest
Tue 4/215:25 am
SFO
- TYS
2 stops11h 15m
Southwest
Deal found 3/14![Southwest logo]()
$483
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/54:38 pm
TYS
- SFO
1 stop9h 09m
Delta
Tue 5/128:30 pm
SFO
- TYS
2 stops10h 04m
Delta
Deal found 3/13![Delta logo]()
$491
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/67:20 pm
TYS
- SFO
1 stop8h 57m
United Airlines
Tue 4/215:00 am
SFO
- TYS
1 stop7h 06m
United Airlines
Deal found 3/12![United Airlines logo]()
$499
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:05 am
TYS
- SFO
1 stop8h 13m
United Airlines
Thu 4/95:00 am
SFO
- TYS
1 stop7h 06m
United Airlines
Deal found 3/11![United Airlines logo]()
$504
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:20 pm
TYS
- SFO
1 stop8h 59m
Delta
Mon 4/69:35 pm
SFO
- TYS
1 stop8h 41m
Delta
Deal found 3/12![Delta logo]()
$504
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/27:05 am
TYS
- SFO
1 stop8h 13m
United Airlines
Thu 4/95:00 am
SFO
- TYS
1 stop7h 06m
United Airlines
Deal found 3/11![United Airlines logo]()
$509
Last-minute flights from Knoxville to San FranciscoDiscover last-minute flight deals from Knoxville to San Francisco. Data last updated March 16, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Francisco. Data last updated March 16, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:30 am
TYS
- SFO
2 stops26h 18m
Multiple Airlines
Sun 4/129:00 pm
SFO
- TYS
1 stop15h 28m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$350
This Frontier deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SFO
1 stop11h 03m
Frontier
Mon 4/136:00 am
SFO
- TYS
1 stop6h 28m
Frontier
Deal found 3/11![Frontier logo]()
$245
This Frontier deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SFO
1 stop11h 03m
Frontier
Sun 4/129:00 pm
SFO
- TYS
1 stop15h 28m
Frontier
Deal found 3/13![Frontier logo]()
$266
This Frontier deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SFO
1 stop11h 03m
Frontier
Thu 4/166:00 am
SFO
- TYS
1 stop6h 33m
Frontier
Deal found 3/11![Frontier logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SFO
1 stop11h 03m
Multiple Airlines
Tue 4/1410:38 pm
SFO
- TYS
2 stops38h 03m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:20 pm
TYS
- SFO
1 stop11h 03m
Frontier
Fri 4/1711:16 pm
SFO
- TYS
2 stops37h 17m
Frontier
Deal found 3/11![Frontier logo]()
$378
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:24 pm
TYS
- SFO
1 stop8h 12m
Delta
Wed 4/155:50 am
SFO
- TYS
1 stop7h 52m
Delta
Deal found 3/11![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:24 pm
TYS
- SFO
1 stop8h 12m
Delta
Mon 4/1310:55 pm
SFO
- TYS
1 stop8h 26m
Delta
Deal found 3/11![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/144:30 pm
TYS
- SFO
1 stop9h 25m
United Airlines
Sun 4/1911:52 pm
SFO
- TYS
1 stop7h 16m
United Airlines
Deal found 3/12![United Airlines logo]()
$359
This Expedia deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:28 pm
TYS
- SFO
1 stop19h 45m
Frontier
Sun 4/196:00 am
SFO
- TYS
1 stop6h 33m
Frontier
Deal found 3/13![Frontier logo]()
$285
One-way flights from Knoxville to San FranciscoSearch for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 16, 2026.
Search for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 16, 2026.
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:28 pm
TYS
- SFO
1 stop19h 45m
Frontier
Deal found 3/15![Frontier logo]()
$116
This CheapOair deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:32 pm
TYS
- SFO
1 stop18h 10m
Frontier
Deal found 3/12![Frontier logo]()
$122
This CheapOair deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- SFO
1 stop18h 10m
Frontier
Deal found 3/12![Frontier logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:43 pm
TYS
- SFO
1 stop23h 58m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$163
This CheapOair deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/258:32 pm
TYS
- SFO
1 stop18h 10m
Frontier
Deal found 3/12![Frontier logo]()
$167
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/94:56 pm
TYS
- SFO
1 stop9h 00m
United Airlines
Deal found 3/12![United Airlines logo]()
$175
Find flight deals from Knoxville to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $245 (Frontier) |
One-way from | $116 (Expedia) |
Popular in | December |
Cheapest in | February |
Average price | $471 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Tue 4/7
5:24 pm-10:36 pm
1 stop8h 12m
San Francisco
Mon 4/13
10:55 pm-10:21 am
1 stop8h 26m
$369
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 6/3
8:15 am-7:55 pm
2 stops14h 40m
San Francisco
Tue 6/9
6:00 am-8:20 pm
2 stops11h 20m
$450
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 4/15
7:20 pm-1:17 am
1 stop8h 57m
San Francisco
Sat 4/18
10:50 am-11:41 pm
1 stop9h 51m
$459
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Tue 4/14
7:05 am-3:20 pm
2 stops11h 15m
San Francisco
Tue 4/21
5:25 am-7:40 pm
2 stops11h 15m
$483
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Tue 5/5
4:38 pm-10:47 pm
1 stop9h 09m
San Francisco
Tue 5/12
8:30 pm-9:34 am
2 stops10h 04m
$491
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Mon 4/6
7:20 pm-1:17 am
1 stop8h 57m
San Francisco
Tue 4/21
5:00 am-3:06 pm
1 stop7h 06m
$499
Quickest round-trip
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Tue 4/7
7:05 am-12:18 pm
1 stop8h 13m
San Francisco
Thu 4/9
5:00 am-3:06 pm
1 stop7h 06m
$504
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Sat 4/4
5:20 pm-11:19 pm
1 stop8h 59m
San Francisco
Mon 4/6
9:35 pm-9:16 am
1 stop8h 41m
$504
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Thu 4/2
7:05 am-12:18 pm
1 stop8h 13m
San Francisco
Thu 4/9
5:00 am-3:06 pm
1 stop7h 06m
$509
Cheapest one-way
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Tue 6/9
4:56 pm-10:56 pm
1 stop9h 00m
$175
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Francisco in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
TYS-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Francisco
How far ahead should I book a flight from Knoxville to San Francisco?
Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Francisco. Price data was last updated on March 13, 2026.
The best time to book flights from Knoxville to San Francisco is 27 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Francisco?
Currently, December is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $194). Flying from Knoxville to San Francisco in March is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated March 16, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
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Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Livermore
Roseville
Watsonville
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Knoxville and San Francisco flights
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Top 4 airlines flying from Knoxville to San Francisco
Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$184 | Average$254 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$302 | Average$449 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$308 | Average$471 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$308 | Average$429 | FlexibilityNo cancel fee | On-time71% |