$160+ Cheap flights from Knoxville to San Francisco (TYS - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
Jun 21 — Jun 281
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to San Francisco with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
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Cheapest flights from Knoxville to San FranciscoExplore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 22, 2026.
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 22, 2026.
This CheapOair deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:32 pm
TYS
- SFO
1 stop27h 22m
Frontier
Wed 8/196:00 am
SFO
- TYS
1 stop10h 37m
Frontier
Deal found 5/18![Frontier logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/32:47 pm
TYS
- SFO
1 stop22h 43m
Multiple Airlines
Tue 8/1110:23 pm
SFO
- TYS
2 stops46h 14m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$337
This CheapOair deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:32 pm
TYS
- SFO
1 stop27h 26m
Frontier
Mon 7/66:00 am
SFO
- TYS
1 stop10h 36m
Frontier
Deal found 5/18![Frontier logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:32 pm
TYS
- SFO
2 stops28h 37m
Multiple Airlines
Sat 8/1512:33 pm
SFO
- TYS
1 stop22h 28m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:32 pm
TYS
- SFO
1 stop30h 46m
Multiple Airlines
Sat 8/87:11 pm
SFO
- TYS
1 stop25h 16m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$345
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/237:00 am
TYS
- SFO
2 stops41h 21m
Multiple Airlines
Sat 8/299:35 pm
SFO
- TYS
1 stop13h 14m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:32 pm
TYS
- SFO
2 stops28h 37m
Multiple Airlines
Wed 8/196:00 am
SFO
- TYS
1 stop28h 49m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:32 pm
TYS
- SFO
1 stop30h 46m
Multiple Airlines
Sun 8/210:56 pm
SFO
- TYS
1 stop12h 01m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:30 am
TYS
- SFO
2 stops39h 44m
Multiple Airlines
Thu 8/2710:50 pm
SFO
- TYS
1 stop19h 56m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$365
Best flights from Knoxville to San FranciscoDiscover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 22, 2026.
Discover carefully curated flight deals from Knoxville to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 22, 2026.
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:05 pm
TYS
- SFO
1 stop7h 44m
Delta
Sun 7/196:00 am
SFO
- TYS
1 stop8h 16m
Delta
Deal found 5/21![Delta logo]()
$389
This United Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:15 am
TYS
- SFO
1 stop7h 59m
United Airlines
Mon 8/3110:35 pm
SFO
- TYS
1 stop8h 13m
United Airlines
Deal found 5/19![United Airlines logo]()
$389
This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:00 am
TYS
- SFO
2 stops9h 15m
Southwest
Tue 9/111:40 pm
SFO
- TYS
2 stops9h 25m
Southwest
Deal found 5/19![Southwest logo]()
$399
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:40 am
TYS
- SFO
1 stop7h 40m
Delta
Tue 7/1410:55 pm
SFO
- TYS
1 stop8h 25m
Delta
Deal found 5/18![Delta logo]()
$389
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/243:54 pm
TYS
- SFO
1 stop7h 11m
Delta
Mon 8/310:10 pm
SFO
- TYS
1 stop8h 30m
Delta
Deal found 5/18![Delta logo]()
$389
This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:00 am
TYS
- SFO
2 stops9h 15m
Southwest
Wed 8/196:00 am
SFO
- TYS
2 stops9h 55m
Southwest
Deal found 5/19![Southwest logo]()
$433
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:43 pm
TYS
- SFO
1 stop7h 53m
Delta
Tue 7/215:40 am
SFO
- TYS
1 stop6h 38m
Delta
Deal found 5/21![Delta logo]()
$389
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/163:54 pm
TYS
- SFO
1 stop8h 54m
Delta
Sun 7/196:00 am
SFO
- TYS
1 stop8h 16m
Delta
Deal found 5/21![Delta logo]()
$389
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2411:41 am
TYS
- SFO
1 stop9h 33m
Delta
Wed 8/56:50 am
SFO
- TYS
2 stops13h 10m
Delta
Deal found 5/18![Delta logo]()
$422
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:55 am
TYS
- SFO
1 stop8h 12m
Delta
Sun 7/1210:59 pm
SFO
- TYS
1 stop9h 06m
Delta
Deal found 5/21![Delta logo]()
$434
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/163:54 pm
TYS
- SFO
1 stop9h 55m
Delta
Tue 6/2311:59 pm
SFO
- TYS
1 stop6h 54m
Delta
Deal found 5/20![Delta logo]()
$489
Last-minute flights from Knoxville to San FranciscoDiscover last-minute flight deals from Knoxville to San Francisco. Data last updated May 22, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Francisco. Data last updated May 22, 2026 and is based on user searches.
This Priceline deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:19 pm
TYS
- SFO
1 stop7h 04m
Frontier
Mon 6/16:00 am
SFO
- TYS
1 stop10h 33m
Frontier
Deal found 5/18![Frontier logo]()
$420
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:00 am
TYS
- SFO
2 stops14h 57m
Multiple Airlines
Wed 6/106:00 am
SFO
- TYS
1 stop10h 37m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:40 pm
TYS
- SFO
1 stop10h 09m
American Airlines
Mon 6/812:26 am
SFO
- TYS
1 stop9h 36m
American Airlines
Deal found 5/19![American Airlines logo]()
$429
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:00 am
TYS
- SFO
2 stops41h 16m
Multiple Airlines
Wed 6/106:00 am
SFO
- TYS
1 stop10h 37m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$405
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:30 pm
TYS
- SFO
2 stops21h 13m
Multiple Airlines
Wed 6/106:00 am
SFO
- TYS
1 stop10h 37m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$415
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:32 pm
TYS
- SFO
2 stops20h 44m
Frontier
Mon 6/156:00 am
SFO
- TYS
1 stop10h 37m
Frontier
Deal found 5/18![Frontier logo]()
$413
This CheapOair deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:32 pm
TYS
- SFO
1 stop18h 11m
Frontier
Mon 6/226:00 am
SFO
- TYS
1 stop10h 37m
Frontier
Deal found 5/18![Frontier logo]()
$400
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- SFO
1 stop9h 05m
Delta
Wed 7/1511:59 pm
SFO
- TYS
1 stop8h 06m
Delta
Deal found 5/19![Delta logo]()
$389
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- SFO
1 stop9h 05m
Delta
Sat 7/1811:59 pm
SFO
- TYS
1 stop6h 37m
Delta
Deal found 5/19![Delta logo]()
$414
One-way flights from Knoxville to San FranciscoSearch for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 22, 2026.
Search for one-way flight options from Knoxville to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/32:47 pm
TYS
- SFO
2 stops46h 38m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$160
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/168:11 pm
TYS
- SFO
1 stop7h 32m
American Airlines
Deal found 5/22![American Airlines logo]()
$195
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:40 am
TYS
- SFO
1 stop8h 53m
Delta
Deal found 5/20![Delta logo]()
$198
This CheapOair deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- SFO
1 stop18h 15m
Frontier
Deal found 5/18![Frontier logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:00 am
TYS
- SFO
2 stops14h 55m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:30 pm
TYS
- SFO
2 stops21h 13m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/302:06 pm
TYS
- SFO
3 stops45h 37m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/27:00 am
TYS
- SFO
2 stops38h 18m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$224
This Mytrip deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:32 pm
TYS
- SFO
1 stop14h 29m
Frontier
Deal found 5/21![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:04 pm
TYS
- SFO
2 stops28h 53m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$228
Find flight deals from Knoxville to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $320 (CheapOair) |
One-way from | $160 (Kiwi.com) |
Popular in | June |
Cheapest in | February |
Average price | $574 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 22, 2026.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 7/15
6:05 pm-10:49 pm
1 stop7h 44m
San Francisco
Sun 7/19
6:00 am-5:16 pm
1 stop8h 16m
$389
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Thu 8/27
7:15 am-12:14 pm
1 stop7h 59m
San Francisco
Mon 8/31
10:35 pm-9:48 am
1 stop8h 13m
$389
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Tue 7/14
5:40 am-10:20 am
1 stop7h 40m
San Francisco
Tue 7/14
10:55 pm-10:20 am
1 stop8h 25m
$389
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Fri 7/24
3:54 pm-8:05 pm
1 stop7h 11m
San Francisco
Mon 8/3
10:10 pm-9:40 am
1 stop8h 30m
$389
Quickest round-trip
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Thu 7/16
7:43 pm-12:36 am
1 stop7h 53m
San Francisco
Tue 7/21
5:40 am-3:18 pm
1 stop6h 38m
$389
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Thu 7/16
3:54 pm-9:48 pm
1 stop8h 54m
San Francisco
Sun 7/19
6:00 am-5:16 pm
1 stop8h 16m
$389
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Tue 8/25
7:00 am-1:15 pm
2 stops9h 15m
San Francisco
Tue 9/1
11:40 pm-12:05 pm
2 stops9h 25m
$399
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Fri 7/24
11:41 am-6:14 pm
1 stop9h 33m
San Francisco
Wed 8/5
6:50 am-11:00 pm
2 stops13h 10m
$422
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Wed 8/12
7:00 am-1:15 pm
2 stops9h 15m
San Francisco
Wed 8/19
6:00 am-6:55 pm
2 stops9h 55m
$433
KnoxvilleSan Francisco
TYS - SFO
TYSSFO
Knoxville McGhee Tyson
Fri 7/3
11:55 am-5:07 pm
1 stop8h 12m
San Francisco
Sun 7/12
10:59 pm-11:05 am
1 stop9h 06m
$434
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Francisco in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
TYS-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Francisco
How far ahead should I book a flight from Knoxville to San Francisco?
The best time to book flights from Knoxville to San Francisco is 26 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Knoxville to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $329). Flying from Knoxville to San Francisco in June is currently the most expensive (average of $621). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to San Francisco?
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated May 22, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Knoxville to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
San Bruno
Watsonville
San Ramon
Vacaville
Roseville
San Carlos
Redwood City
Sunnyvale
Turlock
Vallejo
San Lorenzo
Davis
Emeryville
Manteca
Elk Grove
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Knoxville and San Francisco flights
Browse other Knoxville and San Francisco flight options. Last updated on May 22, 2026.
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Top 4 airlines flying from Knoxville to San Francisco
Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$184 | Average$254 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$256 | Average$465 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$308 | Average$443 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$321 | Average$500 | FlexibilityNo cancel fee | On-time69% |