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$127+ Cheap flights from Knoxville to San Francisco (TYS - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/21. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SFO
may. 28 — jun. 41
mié. 5/28
mié. 6/4
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Francisco are usually found in September or January, booked 89 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from Knoxville to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated mayo 23, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$288
(Priceline)

One-way from

$201
(Mytrip)

Popular in

July

Cheapest in

September

Average price

$408
Provider with most accurate pricing for Knoxville McGhee Tyson-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Francisco flights.
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From Knoxville McGhee Tyson to San Francisco
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One-way flight from Knoxville McGhee Tyson to San Francisco
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Highest demand for flights based on searches. 18% potential increase in price ($100 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Knoxville to San Francisco

Cheapest flights from Knoxville to San Francisco
Explore the most affordable flight options available from Knoxville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on mayo 23, 2025.

This Priceline deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/315:25 pmTYS - SFO
1 stop9h 54mFrontier
jue. 8/76:37 amSFO - TYS
1 stop6h 52mFrontier
Deal found 5/21$288
This United Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/317:35 pmTYS - SFO
1 stop8h 22mUnited Airlines
lun. 8/411:55 pmSFO - TYS
1 stop7h 22mUnited Airlines
Deal found 5/21$309
This American Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/251:56 pmTYS - SFO
1 stop9h 19mAmerican Airlines
vie. 7/49:15 amSFO - TYS
2 stops8h 52mAmerican Airlines
Deal found 5/22$314
This Mytrip deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/263:09 pmTYS - SFO
2 stops19h 59mMultiple Airlines
dom. 6/2911:59 pmSFO - TYS
1 stop13h 12mMultiple Airlines
Deal found 5/23$366
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/32:04 pmTYS - SFO
1 stop9h 05mDelta
lun. 6/911:59 pmSFO - TYS
1 stop8h 09mDelta
Deal found 5/22$412
This Alaska Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/156:00 amTYS - SFO
2 stops15h 28mAlaska Airlines
sáb. 7/199:45 amSFO - TYS
1 stop9h 07mAlaska Airlines
Deal found 5/22$657

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated mayo 23, 2025.
Use the filters below to find and compare flights from Knoxville to San Francisco that are best for you.

Fly from

Knoxville

Fly to

San Francisco

Route

Depart

Return

Price

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

jue. 7/31

5:25 pm-12:19 am

1 stop9h 54m

San Francisco

jue. 8/7

6:37 am-4:29 pm

1 stop6h 52m

$288

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

vie. 7/4

7:00 am-11:29 am

1 stop7h 29m

San Francisco

lun. 7/7

10:55 pm-10:17 am

1 stop8h 22m

$293

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

vie. 7/4

2:48 pm-8:58 pm

2 stops9h 10m

San Francisco

lun. 7/7

11:47 pm-12:34 pm

1 stop9h 47m

$298

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

jue. 6/26

3:09 pm-8:08 am

2 stops19h 59m

San Francisco

dom. 6/29

11:59 pm-4:11 pm

1 stop13h 12m

$366

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

mar. 6/3

2:04 pm-8:09 pm

1 stop9h 05m

San Francisco

lun. 6/9

11:59 pm-11:08 am

1 stop8h 09m

$412

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

jue. 7/24

6:22 pm-8:00 am

2 stops16h 38m

San Francisco

mar. 7/29

7:20 am-11:52 pm

2 stops13h 32m

$680

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

lun. 7/21

11:01 am-5:11 pm

1 stop9h 10m

$127

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

dom. 8/17

5:25 pm-12:19 am

1 stop9h 54m

$138

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

mié. 7/9

6:22 pm-12:08 am

1 stop8h 46m

$270

KnoxvilleSan Francisco

TYS - SFO

TYSSFO

Knoxville McGhee Tyson

sáb. 6/21

7:25 am-12:16 pm

1 stop7h 51m

$320

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/21

Compare providers for flights from Knoxville to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Francisco in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Francisco

How far ahead should I book a flight from Knoxville to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Francisco. Price data was last updated on May 16, 2025.

The best time to book flights from Knoxville to San Francisco is 89 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $276). Flying from Knoxville to San Francisco in June is currently the most expensive (average of $375). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SFO?

Find hourly flight availability from Knoxville to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated mayo 23, 2025.

One of the essential ways to save on airfare from Knoxville to San Francisco is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 30% on airfare.

What is the cheapest day to fly from Knoxville to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to San Francisco. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to San Francisco flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated mayo 23, 2025.
Read reviews from past customers who have flown Alaska Airlines, Delta and United Airlines from Knoxville to San Francisco. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Food

7.1

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Food

7.1

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,950 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Food

7.1

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,745 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Food

7.1

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Food

7.1

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
6.0
Okay
3,288 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Food

7.1

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to San Francisco round-trip?

    Flying on Frontier is currently your cheapest option to San Francisco, with prices starting at $288. Additional round-trip tickets that might be worth considering are offered by Delta and American Airlines, with the lowest prices starting at $309 and $314, respectively. Frontier is priced at 35% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Knoxville to San Francisco that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Francisco.

  • Can I find deals for business class flights from Knoxville to San Francisco?

    Yes. Cheapflights offers flight deals from Knoxville to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to San Francisco (average of $276). Flying from Knoxville to San Francisco in June is currently the most expensive (average of $375). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Roseville
Mountain View
Santa Cruz
Livermore
South San Francisco
Turlock
Watsonville
Manteca
Fairfield
Newark
Antioch
Hollister
Milpitas
Richmond
Hayward
Alameda
Sunnyvale
Daly City
Campbell
Union City

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Top 4 airlines flying from Knoxville to San Francisco

Discover the top 4 airlines that operate flights from Knoxville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated mayo 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$155Average$188FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$248Average$523FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$308Average$447FlexibilityNo cancel feeOn-time71%
DeltaCheapest$308Average$420FlexibilityNo cancel feeOn-timeN/A

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