Knoxville

$80+ Cheap flights from San Francisco to Knoxville (SFO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — TYS
Jul 7 — Jul 141
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Cheapflights Tip: The best prices from San Francisco to Knoxville McGhee Tyson are usually found in August or February, booked 82 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from San Francisco to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 2, 2025.

Round-trip from

$243
(Priceline)

One-way from

$80
(Priceline)

Popular in

December

Cheapest in

August

Average price

$467
From San Francisco to Knoxville McGhee Tyson
One-way flight from San Francisco to Knoxville McGhee Tyson
Highest demand for flights based on searches. 7% potential increase in price ($40 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Average for round-trip flights in July 2025

Find flight deals from San Francisco to Knoxville

Cheapest flights from San Francisco to Knoxville
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

This Priceline deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/106:37 amSFO - TYS
1 stop6h 52mFrontier
Sun 7/135:25 pmTYS - SFO
1 stop9h 54mFrontier
Deal found 6/30$243
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/47:00 amSFO - TYS
1 stop8h 23mDelta
Thu 10/96:05 pmTYS - SFO
1 stop8h 44mDelta
Deal found 6/30$309
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1411:55 pmSFO - TYS
1 stop7h 22mUnited Airlines
Thu 7/177:35 pmTYS - SFO
1 stop8h 22mUnited Airlines
Deal found 6/30$369
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/312:55 amSFO - TYS
1 stop9h 17mAmerican Airlines
Sat 8/96:39 pmTYS - SFO
1 stop7h 13mAmerican Airlines
Deal found 7/2$383
This eDestinos deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3011:40 amSFO - TYS
1 stop22h 43mMultiple Airlines
Sun 11/27:00 amTYS - SFO
1 stop20h 14mMultiple Airlines
Deal found 7/2$408

Cheapflights Fare Finder

Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

San Francisco

Fly to

Knoxville

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 7/10

6:37 am-4:29 pm

1 stop6h 52m

Knoxville McGhee Tyson

Sun 7/13

5:25 pm-12:19 am

1 stop9h 54m

$243

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 7/30

7:13 am-6:02 pm

1 stop7h 49m

Knoxville McGhee Tyson

Wed 8/6

5:30 am-10:11 am

1 stop7h 41m

$309

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Tue 7/15

10:59 pm-9:50 am

1 stop7h 51m

Knoxville McGhee Tyson

Tue 7/22

5:30 am-11:34 am

1 stop9h 04m

$339

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 7/14

11:55 pm-10:17 am

1 stop7h 22m

Knoxville McGhee Tyson

Thu 7/17

7:35 pm-12:57 am

1 stop8h 22m

$369

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 7/25

11:59 pm-10:47 pm

2 stops19h 48m

Knoxville McGhee Tyson

Fri 8/1

11:01 am-10:53 pm

1 stop14h 52m

$503

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 8/21

6:26 am-7:41 pm

1 stop10h 15m

$80

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 8/10

11:59 pm-4:12 pm

1 stop13h 13m

$143

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 8/11

10:59 pm-11:03 am

1 stop9h 04m

$155

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 7/19

11:05 pm-10:27 am

1 stop8h 22m

$185

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 8/10

12:45 am-11:30 am

1 stop7h 45m

$346

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from San Francisco to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Knoxville

How far ahead should I book a flight from San Francisco to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Knoxville. Price data was last updated on June 27, 2025.

Booking 50 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Knoxville?

Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $296). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to TYS?

Find hourly flight availability from San Francisco to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2025.

It’s optimal to fly from San Francisco to Knoxville at noon. By choosing this option you can save up to 12% on the cost of your flight, compared to a flight in the morning.

Weekly flight availability from San Francisco to Knoxville

Explore weekly flight availability from San Francisco to Knoxville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 2, 2025.

The most flights from SFO to TYS are scheduled on a Monday (1 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 2, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from San Francisco to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
8.0
Very good

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
8.0
Very good
8.0
Very good

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
8.0
Very good

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
8.0
Very good

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
8.0
Very good

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airports do I use to fly from San Francisco to Knoxville?

    If you book a flight from San Francisco to Knoxville, you will be flying from San Francisco to McGhee Tyson. Flights to Knoxville McGhee Tyson (TYS) from San Francisco (SFO) take 6h 39m for a nonstop flight. There is 1 flight from San Francisco to Knoxville per day from 4 airlines.

  • What are the cheapest airlines flying from San Francisco to Knoxville round-trip?

    Flying on Frontier is currently your cheapest option to Knoxville, with prices starting at $243. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $309 and $339, respectively. Users have found that Frontier is 49% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from San Francisco to Knoxville one-way?

    One-way options have recently been found by users for as low as $80 on Frontier. Other airlines that offer cheap prices include Delta from $155 and United Airlines from $185 one-way.

  • Where are the most common layover locations when flying from San Francisco to Knoxville?

  • What are some popular things to do or see while on a layover in Dallas?

    Most Dallas visitors opt to spend their time experiencing American Airlines Center, Dallas World Aquarium, and Reunion Tower. Those on a layover in Dallas interested in visiting American Airlines Center, Dallas World Aquarium, or Reunion Tower can do so by traveling 15.0 mi, 15.5 mi, and 15.6 mi, respectively from Dallas/Fort Worth. Those looking to explore during their layover in Dallas can rent a car from Dallas/Fort Worth for about $53 per day.

  • Where are the least popular layover locations for San Francisco to Knoxville flights?

  • Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?

    Yes. In addition to deals on San Francisco to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Knoxville.

  • Can I find deals for business class flights from San Francisco to Knoxville?

    Yes. Cheapflights offers flight deals from San Francisco to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $296). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
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Alternative routes for San Francisco to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from San Francisco to Knoxville

Discover the top 4 airlines that operate flights from San Francisco to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$149Average$290FlexibilityNo cancel feeOn-time62%
DeltaCheapest$308Average$430FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$308Average$495FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$326Average$581FlexibilityNo cancel feeOn-time69%

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