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Knoxville

$112+ Cheap flights from San Francisco to Knoxville (SFO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/10. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — TYS
Jul 16 — Jul 231
Wed 7/16
Wed 7/23
1 adult, Economy
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Cheapflights Tip: The best prices from San Francisco to Knoxville McGhee Tyson are usually found in August or February, booked 82 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from San Francisco to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 11, 2025.

Round-trip from

$207
(Priceline)

One-way from

$112
(Priceline)

Popular in

December

Cheapest in

August

Average price

$467
From San Francisco to Knoxville McGhee Tyson
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One-way flight from San Francisco to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 7% potential increase in price ($40 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from San Francisco to Knoxville

Cheapest flights from San Francisco to Knoxville
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 11, 2025.

This Priceline deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/146:37 amSFO - TYS
1 stop6h 52mFrontier
Sun 8/175:25 pmTYS - SFO
1 stop9h 54mFrontier
Deal found 7/8$207
This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/136:00 amSFO - TYS
1 stop12h 00mAmerican Airlines
Thu 9/183:13 pmTYS - SFO
1 stop10h 56mAmerican Airlines
Deal found 7/10$283
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/291:41 pmSFO - TYS
1 stop7h 07mDelta
Wed 9/31:53 pmTYS - SFO
1 stop7h 59mDelta
Deal found 7/10$309
This Mytrip deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/711:59 pmSFO - TYS
1 stop13h 13mMultiple Airlines
Thu 8/148:52 pmTYS - SFO
2 stops29h 01mMultiple Airlines
Deal found 7/8$327
This United Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/115:00 amSFO - TYS
1 stop7h 04mUnited Airlines
Mon 8/117:35 pmTYS - SFO
1 stop8h 22mUnited Airlines
Deal found 7/9$405

Cheapflights Fare Finder

Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 11, 2025.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

San Francisco

Fly to

Knoxville

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 8/14

6:37 am-4:29 pm

1 stop6h 52m

Knoxville McGhee Tyson

Sun 8/17

5:25 pm-12:19 am

1 stop9h 54m

$207

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 9/13

6:00 am-9:00 pm

1 stop12h 00m

Knoxville McGhee Tyson

Thu 9/18

3:13 pm-11:09 pm

1 stop10h 56m

$283

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 8/29

1:41 pm-11:48 pm

1 stop7h 07m

Knoxville McGhee Tyson

Thu 9/4

11:54 am-6:52 pm

1 stop9h 58m

$309

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 8/7

11:59 pm-4:12 pm

1 stop13h 13m

Knoxville McGhee Tyson

Thu 8/14

8:52 pm-10:53 pm

2 stops29h 01m

$327

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 8/11

5:00 am-3:04 pm

1 stop7h 04m

Knoxville McGhee Tyson

Mon 8/11

7:35 pm-12:57 am

1 stop8h 22m

$405

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 8/10

6:37 am-4:29 pm

1 stop6h 52m

$112

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 8/11

9:35 pm-9:30 am

1 stop8h 55m

$155

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 8/10

11:59 pm-10:15 pm

2 stops19h 16m

$199

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 8/8

5:00 am-6:11 pm

1 stop10h 11m

$205

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 8/9

12:15 pm-8:50 am

2 stops17h 35m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/9

Showing 1-10 of 11 results
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Best time to book a flight from San Francisco to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Knoxville

How far ahead should I book a flight from San Francisco to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Knoxville. Price data was last updated on June 27, 2025.

Booking 50 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Knoxville?

Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $296). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to TYS?

Find hourly flight availability from San Francisco to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 11, 2025.

It’s optimal to fly from San Francisco to Knoxville at noon. By choosing this option you can save up to 12% on the cost of your flight, compared to a flight in the morning.

Weekly flight availability from San Francisco to Knoxville

Explore weekly flight availability from San Francisco to Knoxville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 11, 2025.

The most flights from SFO to TYS are scheduled on a Monday (1 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 11, 2025.
Peruse reviews from past customers who have flown with Alaska Airlines, Delta, and United Airlines from San Francisco to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,951 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,846 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
5.9
Fair
3,271 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Comfort

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from San Francisco to Knoxville?

    If you book a flight from San Francisco to Knoxville, you will be flying from San Francisco to McGhee Tyson. Flights to Knoxville McGhee Tyson (TYS) from San Francisco (SFO) take 7h 34m for a nonstop flight. There is 1 flight from San Francisco to Knoxville per day from 4 airlines.

  • What are the cheapest airlines flying from San Francisco to Knoxville round-trip?

    Flying on Frontier is currently your cheapest option to Knoxville, with prices starting at $207. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $283 and $309, respectively. Users have found that Frontier is 57% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from San Francisco to Knoxville one-way?

    One-way options have recently been found by users for as low as $112 on Frontier. Other airlines that offer cheap prices include Delta from $155 and United Airlines from $205 one-way.

  • Where are the most common layover locations when flying from San Francisco to Knoxville?

    San Francisco to Knoxville flights have a layover in Dallas most often.

  • What are some popular things to do or see while on a layover in Dallas?

    Most Dallas visitors opt to spend their time experiencing American Airlines Center, Dallas World Aquarium, and Reunion Tower. Those on a layover in Dallas interested in visiting American Airlines Center, Dallas World Aquarium, or Reunion Tower can do so by traveling 15.0 mi, 15.5 mi, and 15.6 mi, respectively from Dallas/Fort Worth. Those looking to explore during their layover in Dallas can rent a car from Dallas/Fort Worth for about $51 per day.

  • Where are the least popular layover locations for San Francisco to Knoxville flights?

    Flights departing from San Francisco and landing in Knoxville layover in Charlotte least frequently.

  • Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?

    Yes. In addition to deals on San Francisco to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Knoxville.

  • Can I find deals for business class flights from San Francisco to Knoxville?

    Yes. Cheapflights offers flight deals from San Francisco to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $296). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Morristown
Corbin
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Alcoa
Oak Ridge
Murphy

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Top 4 airlines flying from San Francisco to Knoxville

Discover the top 4 airlines that operate flights from San Francisco to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$149Average$276FlexibilityNo cancel feeOn-time62%
DeltaCheapest$308Average$429FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$308Average$491FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$338Average$580FlexibilityNo cancel feeOn-time69%

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