What are the cheapest airlines flying from San Francisco to Knoxville round-trip?

Flying on Frontier is currently your cheapest option to Knoxville, with prices starting at $243. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $309 and $339, respectively. Users have found that Frontier is 49% cheaper than the other options available to this destination.

What are the cheapest airlines to fly from San Francisco to Knoxville one-way?

One-way options have recently been found by users for as low as $80 on Frontier. Other airlines that offer cheap prices include Delta from $155 and United Airlines from $185 one-way.

What is the cheapest day to fly from San Francisco to Knoxville?

Travelers seeking maximum savings on their San Francisco to Knoxville flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What are the most popular airlines that fly from San Francisco to Knoxville?

The most popular airlines flying from San Francisco to Knoxville are American Airlines, Delta and Frontier. Something to consider prior to booking your flight.

Where are the most common layover locations when flying from San Francisco to Knoxville?

San Francisco to Knoxville flights have a layover in Dallas most often.

Where are the least popular layover locations for San Francisco to Knoxville flights?

Flights departing from San Francisco and landing in Knoxville layover in Charlotte least frequently.

What are some popular things to do or see while on a layover in Dallas?

Most Dallas visitors opt to spend their time experiencing American Airlines Center, Dallas World Aquarium, and Reunion Tower. Those on a layover in Dallas interested in visiting American Airlines Center, Dallas World Aquarium, or Reunion Tower can do so by traveling 15.0 mi, 15.5 mi, and 15.6 mi, respectively from Dallas/Fort Worth. Those looking to explore during their layover in Dallas can rent a car from Dallas/Fort Worth for about $53 per day.

What is the cheapest day to fly round-trip from San Francisco to Knoxville?

Leaving on a Monday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 30% on the overall cost on flights from San Francisco to Knoxville.

How far in advance should I book a flight from San Francisco to Knoxville?

To save on the cost of your flight from San Francisco to Knoxville, book at least 51 days before your planned departure. Booking around this time can save you about 75% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $458 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $550.

What is the cheapest month to fly from San Francisco to Knoxville?

Due to multiple factors, expect to potentially pay more when booking in December. For low rates, August can be a great choice for travel to Knoxville. Flights to Knoxville from San Francisco in August are about $482 on average during August, but can be found for as low as $256.

What airports do I use to fly from San Francisco to Knoxville?

If you book a flight from San Francisco to Knoxville, you will be flying from San Francisco to McGhee Tyson. Flights to Knoxville McGhee Tyson (TYS) from San Francisco (SFO) take 6h 39m for a nonstop flight. There is 1 flight from San Francisco to Knoxville per day from 4 airlines.

Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?

Yes. In addition to deals on San Francisco to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Francisco to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Knoxville.

Can I find deals for business class flights from San Francisco to Knoxville?

Yes. Cheapflights offers flight deals from San Francisco to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$80+ Flights from San Francisco to Knoxville

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Cheapflights Tip: The best prices from San Francisco to Knoxville McGhee Tyson are usually found in August or February, booked 82 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from San Francisco to Knoxville

Round-trip from	$243 (Priceline)
One-way from	$80 (Priceline)
Popular in	December
Cheapest in	August
Average price	$467

From San Francisco to Knoxville McGhee Tyson

Search Deals

One-way flight from San Francisco to Knoxville McGhee Tyson

Search Deals

Highest demand for flights based on searches. 7% potential increase in price ($40 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from San Francisco to Knoxville

Cheapest flights from San Francisco to Knoxville
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

Thu 7/106:37 amSFO - TYS

1 stop6h 52mFrontier

Sun 7/135:25 pmTYS - SFO

1 stop9h 54mFrontier

Deal found 6/30

$243

Sat 10/47:00 amSFO - TYS

1 stop8h 23mDelta

Thu 10/96:05 pmTYS - SFO

1 stop8h 44mDelta

Deal found 6/30

$309

Mon 7/1411:55 pmSFO - TYS

1 stop7h 22mUnited Airlines

Thu 7/177:35 pmTYS - SFO

1 stop8h 22mUnited Airlines

Deal found 6/30

$369

Sun 8/312:55 amSFO - TYS

1 stop9h 17mAmerican Airlines

Sat 8/96:39 pmTYS - SFO

1 stop7h 13mAmerican Airlines

Deal found 7/2

$383

Thu 10/3011:40 amSFO - TYS

1 stop22h 43mMultiple Airlines

Sun 11/27:00 amTYS - SFO

1 stop20h 14mMultiple Airlines

Deal found 7/2

$408

Best flights from San Francisco to Knoxville
Discover carefully curated flight deals from San Francisco to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 2, 2025.

Thu 7/106:37 amSFO - TYS

1 stop6h 52mFrontier

Sun 7/135:25 pmTYS - SFO

1 stop9h 54mFrontier

Deal found 6/30

$243

Wed 7/307:13 amSFO - TYS

1 stop7h 49mAmerican Airlines

Wed 8/65:30 amTYS - SFO

1 stop7h 41mAmerican Airlines

Deal found 6/30

$309

Tue 7/1510:59 pmSFO - TYS

1 stop7h 51mDelta

Tue 7/225:30 amTYS - SFO

1 stop9h 04mDelta

Deal found 7/2

$339

Mon 7/1411:55 pmSFO - TYS

1 stop7h 22mUnited Airlines

Thu 7/177:35 pmTYS - SFO

1 stop8h 22mUnited Airlines

Deal found 6/30

$369

Thu 7/3111:59 pmSFO - TYS

1 stop13h 13mMultiple Airlines

Mon 8/111:12 pmTYS - SFO

2 stops25h 36mMultiple Airlines

Deal found 7/2

$461

Last-minute flights from San Francisco to Knoxville
Discover last-minute flight deals from San Francisco to Knoxville. Data last updated July 2, 2025 and is based on user searches.

Mon 7/712:55 amSFO - TYS

1 stop9h 17mAmerican Airlines

Wed 7/166:00 amTYS - SFO

1 stop7h 28mAmerican Airlines

Deal found 7/2

$412

Mon 7/712:30 amSFO - TYS

1 stop10h 11mUnited Airlines

Wed 7/165:46 pmTYS - SFO

2 stops16h 51mUnited Airlines

Deal found 7/2

$600

Tue 7/811:35 amSFO - TYS

1 stop6h 41mDelta

Wed 7/165:12 pmTYS - SFO

1 stop8h 16mDelta

Deal found 7/2

$407

Mon 7/1411:55 pmSFO - TYS

1 stop7h 22mUnited Airlines

Thu 7/177:35 pmTYS - SFO

1 stop8h 22mUnited Airlines

Deal found 6/30

$369

Tue 7/1510:59 pmSFO - TYS

1 stop7h 51mDelta

Tue 7/225:30 amTYS - SFO

1 stop9h 04mDelta

Deal found 7/2

$339

Wed 7/305:23 amSFO - TYS

1 stop9h 39mAmerican Airlines

Wed 8/65:30 amTYS - SFO

1 stop7h 41mAmerican Airlines

Deal found 7/1

$309

Thu 7/3111:59 pmSFO - TYS

1 stop13h 13mMultiple Airlines

Mon 8/111:12 pmTYS - SFO

2 stops25h 36mMultiple Airlines

Deal found 7/2

$461

Thu 8/216:26 amSFO - TYS

1 stop10h 15mFrontier

Thu 8/288:36 pmTYS - SFO

1 stop6h 43mFrontier

Deal found 7/1

$322

One-way flights from San Francisco to Knoxville
Search for one-way flight options from San Francisco to Knoxville. Find affordable one-way fares based on user searches. Data last updated July 2, 2025.

Thu 8/216:26 amSFO - TYS

1 stop10h 15mFrontier

Deal found 6/30

$80

Sun 8/1011:59 pmSFO - TYS

1 stop13h 13mMultiple Airlines

Deal found 7/1

$143

Mon 8/1110:59 pmSFO - TYS

1 stop9h 04mDelta

Deal found 7/2

$155

Sat 7/1911:05 pmSFO - TYS

1 stop8h 22mUnited Airlines

Deal found 7/1

$185

Sun 8/1012:45 amSFO - TYS

1 stop7h 45mAmerican Airlines

Deal found 7/2

$346

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 7/10

6:37 am-4:29 pm

1 stop6h 52m

Knoxville McGhee Tyson

Sun 7/13

5:25 pm-12:19 am

1 stop9h 54m

$243

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 7/30

7:13 am-6:02 pm

1 stop7h 49m

Knoxville McGhee Tyson

Wed 8/6

5:30 am-10:11 am

1 stop7h 41m

$309

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Tue 7/15

10:59 pm-9:50 am

1 stop7h 51m

Knoxville McGhee Tyson

Tue 7/22

5:30 am-11:34 am

1 stop9h 04m

$339

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 7/14

11:55 pm-10:17 am

1 stop7h 22m

Knoxville McGhee Tyson

Thu 7/17

7:35 pm-12:57 am

1 stop8h 22m

$369

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 7/25

11:59 pm-10:47 pm

2 stops19h 48m

Knoxville McGhee Tyson

Fri 8/1

11:01 am-10:53 pm

1 stop14h 52m

$503

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 8/21

6:26 am-7:41 pm

1 stop10h 15m

$80

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 8/10

11:59 pm-4:12 pm

1 stop13h 13m

$143

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 8/11

10:59 pm-11:03 am

1 stop9h 04m

$155

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 7/19

11:05 pm-10:27 am

1 stop8h 22m

$185

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 8/10

12:45 am-11:30 am

1 stop7h 45m

$346

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from San Francisco to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Knoxville

How far ahead should I book a flight from San Francisco to Knoxville?

Booking 50 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Knoxville?

Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $296). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to TYS?

It’s optimal to fly from San Francisco to Knoxville at noon. By choosing this option you can save up to 12% on the cost of your flight, compared to a flight in the morning.

Weekly flight availability from San Francisco to Knoxville

The most flights from SFO to TYS are scheduled on a Monday (1 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).

Reviews of airlines servicing Knoxville

Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from San Francisco to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,975 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Delta

8.0

Very good

7,975 reviews

Delta

8.0

Very good

7,975 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

United Airlines

7.4

Good

8,861 reviews

Delta

8.0

Very good

7,975 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,975 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Frontier

5.9

Fair

3,286 reviews

Delta

8.0

Very good

7,975 reviews

Reviews

1 / 20

10.0

Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

What airports do I use to fly from San Francisco to Knoxville?
If you book a flight from San Francisco to Knoxville, you will be flying from San Francisco to McGhee Tyson. Flights to Knoxville McGhee Tyson (TYS) from San Francisco (SFO) take 6h 39m for a nonstop flight. There is 1 flight from San Francisco to Knoxville per day from 4 airlines.
What are the cheapest airlines flying from San Francisco to Knoxville round-trip?
Flying on Frontier is currently your cheapest option to Knoxville, with prices starting at $243. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $309 and $339, respectively. Users have found that Frontier is 49% cheaper than the other options available to this destination.
What are the cheapest airlines to fly from San Francisco to Knoxville one-way?
One-way options have recently been found by users for as low as $80 on Frontier. Other airlines that offer cheap prices include Delta from $155 and United Airlines from $185 one-way.
Where are the most common layover locations when flying from San Francisco to Knoxville?
San Francisco to Knoxville flights have a layover in Dallas most often.
What are some popular things to do or see while on a layover in Dallas?
Most Dallas visitors opt to spend their time experiencing American Airlines Center, Dallas World Aquarium, and Reunion Tower. Those on a layover in Dallas interested in visiting American Airlines Center, Dallas World Aquarium, or Reunion Tower can do so by traveling 15.0 mi, 15.5 mi, and 15.6 mi, respectively from Dallas/Fort Worth. Those looking to explore during their layover in Dallas can rent a car from Dallas/Fort Worth for about $53 per day.
Where are the least popular layover locations for San Francisco to Knoxville flights?
Flights departing from San Francisco and landing in Knoxville layover in Charlotte least frequently.
Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?
Yes. In addition to deals on San Francisco to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Francisco to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Knoxville.
Can I find deals for business class flights from San Francisco to Knoxville?
Yes. Cheapflights offers flight deals from San Francisco to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Francisco to Knoxville?
Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $296). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Complete your trip

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Other flights to Knoxville

Top 4 airlines flying from San Francisco to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$149	Average$290	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$308	Average$430	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$308	Average$495	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$326	Average$581	FlexibilityNo cancel fee	On-time69%

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$80+ Cheap flights from San Francisco to Knoxville (SFO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Francisco to Knoxville with Cheapflights

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Cheapflights Tip: The best prices from San Francisco to Knoxville McGhee Tyson are usually found in August or February, booked 82 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from San Francisco to Knoxville

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from San Francisco to Knoxville

Cheapest flights from San Francisco to KnoxvilleExplore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Best time to book a flight from San Francisco to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Knoxville

How far ahead should I book a flight from San Francisco to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Knoxville. Price data was last updated on June 27, 2025.

What is the cheapest month to book a flight from San Francisco to Knoxville?

What is the cheapest time of day to fly from SFO to TYS?

Find hourly flight availability from San Francisco to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2025.

Weekly flight availability from San Francisco to Knoxville

Reviews of airlines servicing Knoxville

Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from San Francisco to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from San Francisco to Knoxville?

What are the cheapest airlines flying from San Francisco to Knoxville round-trip?

What are the cheapest airlines to fly from San Francisco to Knoxville one-way?

Where are the most common layover locations when flying from San Francisco to Knoxville?

What are some popular things to do or see while on a layover in Dallas?

Where are the least popular layover locations for San Francisco to Knoxville flights?

Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?

How can I find direct flights from San Francisco to Knoxville?

Can I find deals for business class flights from San Francisco to Knoxville?

What is the cheapest month to book a flight from San Francisco to Knoxville?

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Top 4 airlines flying from San Francisco to Knoxville

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Cheapest flights from San Francisco to Knoxville
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.