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Knoxville

$138+ Cheap flights from Santa Ana, CA to Knoxville (SNA - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/1. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — TYS
Aug 22 — Aug 291
Sat 8/22
Sat 8/29
1 adult, Economy
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Cheap flight deals from Santa Ana to Knoxville

Cheapest flights from Santa Ana to Knoxville
Explore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.

This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:30 am
SNA
-
TYS
1 stop10h 22m
Multiple Airlines
Sun 11/812:29 pm
TYS
-
SNA
1 stop28h 03m
Multiple Airlines
Deal found 7/22$298
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/179:03 am
SNA
-
TYS
1 stop7h 21m
Multiple Airlines
Mon 8/248:30 am
TYS
-
SNA
2 stops33h 31m
Multiple Airlines
Deal found 7/18$344
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:45 am
SNA
-
TYS
1 stop6h 57m
American Airlines
Wed 9/166:00 am
TYS
-
SNA
1 stop6h 45m
American Airlines
Deal found 7/22$355
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:45 am
SNA
-
TYS
1 stop6h 09m
United Airlines
Tue 8/257:15 am
TYS
-
SNA
2 stops10h 57m
United Airlines
Deal found 7/21$360
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:03 pm
SNA
-
TYS
2 stops26h 09m
Multiple Airlines
Wed 8/128:19 pm
TYS
-
SNA
1 stop17h 09m
Multiple Airlines
Deal found 7/20$361
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:27 pm
SNA
-
TYS
1 stop28h 38m
Multiple Airlines
Mon 10/56:40 am
TYS
-
SNA
1 stop9h 52m
Multiple Airlines
Deal found 7/21$365
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:45 am
SNA
-
TYS
2 stops9h 10m
Southwest
Tue 8/257:00 am
TYS
-
SNA
2 stops10h 00m
Southwest
Deal found 7/21$366

Find flight deals from Santa Ana to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$344
(Kiwi.com)

One-way from

$138
(Kiwi.com)

Popular in

June

Cheapest in

November

Average price

$609
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flights.
Search Deals
From Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
Search Deals
One-way flight from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($132 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 8/27

12:06 pm-9:45 pm

1 stop6h 39m

Knoxville McGhee Tyson

Tue 9/1

7:15 am-11:02 am

1 stop6h 47m

$355

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 8/19

6:45 am-3:54 pm

1 stop6h 09m

Knoxville McGhee Tyson

Tue 8/25

7:15 am-3:12 pm

2 stops10h 57m

$360

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 8/27

8:45 pm-12:00 pm

2 stops12h 15m

Knoxville McGhee Tyson

Tue 9/1

7:00 am-2:00 pm

2 stops10h 00m

$371

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 8/12

6:45 am-6:55 pm

2 stops9h 10m

Knoxville McGhee Tyson

Wed 9/2

3:00 pm-6:35 pm

1 stop6h 35m

$372

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 8/26

6:45 am-6:55 pm

2 stops9h 10m

Knoxville McGhee Tyson

Mon 8/31

4:50 pm-10:05 pm

2 stops8h 15m

$378

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 8/18

12:03 pm-9:45 pm

1 stop6h 42m

Knoxville McGhee Tyson

Mon 8/24

3:40 pm-10:17 pm

2 stops9h 37m

$384

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 9/9

6:45 am-3:54 pm

1 stop6h 09m

Knoxville McGhee Tyson

Mon 9/14

6:02 pm-10:25 pm

1 stop7h 23m

$407

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 8/18

6:45 am-6:55 pm

2 stops9h 10m

Knoxville McGhee Tyson

Mon 8/24

4:50 pm-10:05 pm

2 stops8h 15m

$428

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 8/17

8:45 pm-12:05 pm

2 stops12h 20m

Knoxville McGhee Tyson

Mon 8/24

4:50 pm-10:05 pm

2 stops8h 15m

$434

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 9/16

7:30 am-1:44 pm

2 stops27h 14m

Knoxville McGhee Tyson

Sun 9/20

8:20 am-5:35 pm

1 stop12h 15m

$458

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/22

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Compare providers for flights from Santa Ana to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Knoxville in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santa Ana, California-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana, California-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana, California-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Knoxville

How far ahead should I book a flight from Santa Ana, California to Knoxville?

Booking 30 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santa Ana, California to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Santa Ana, California to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Santa Ana, California to Knoxville (average of $362). Flying from Santa Ana, California to Knoxville in June is currently the most expensive (average of $727). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Santa Ana, California to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 23, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Santa Ana to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.
Southwest
8.0
Very good
4,238 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.
Delta
7.8
Good
8,479 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.
United Airlines
7.4
Good
10,024 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.
American Airlines
7.1
Good
11,832 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Ana, California to Knoxville?

    Airlines like United Airlines and Southwest fly from Santa Ana, California to Knoxville in about 6h 39m. The time it takes to get you to your destination can typically vary by up to 5h 36m. The distance from Santa Ana, California to Knoxville is about 1918 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Santa Ana, California to Knoxville round-trip?

    Delta, at $174, was found to be the cheapest airline from Santa Ana, California to Knoxville.Alternate airlines to your destination round-trip include American Airlines and United Airlines. Delta is priced at 65% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Santa Ana, California to Knoxville one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $149. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Santa Ana, California to Knoxville for a low price.

  • Can I find deals for flights from Santa Ana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Knoxville.

  • Can I find deals for business class flights from Santa Ana to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Ana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana, California to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Santa Ana, California to Knoxville (average of $362). Flying from Santa Ana, California to Knoxville in June is currently the most expensive (average of $727). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

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Top 4 airlines flying from Santa Ana to Knoxville

Discover the top 4 airlines that operate flights from Santa Ana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$174Average$428FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$288Average$536FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$288Average$485FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$412Average$569FlexibilityNo cancel feeOn-time63%

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