$174+ Cheap flights from Santa Ana, CA to Knoxville (SNA - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/8. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — TYS
Nov 13 — Nov 201
Round-trip
1 adult, Economy
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Find cheap flights from Santa Ana to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santa Ana to Knoxville
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Best
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Cheapest flights from Santa Ana to KnoxvilleExplore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2026.
Explore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/32:15 pm -
1 stop27h 10m
Mon 12/79:15 pm -
1 stop20h 48m
Deal found 10/11![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:30 am -
2 stops26h 49m
Sun 11/158:43 pm -
1 stop25h 28m
Deal found 10/11![Multiple Airlines logo]()
$324
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:07 am -
1 stop9h 25m
Sun 12/61:58 pm -
1 stop22h 24m
Deal found 10/12![Multiple Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/69:41 am -
2 stops26h 26m
Mon 11/910:09 pm -
1 stop19h 54m
Deal found 10/11![Multiple Airlines logo]()
$361
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/102:30 pm -
1 stop6h 27m
Tue 12/155:40 am -
1 stop9h 08m
Deal found 10/13![Delta logo]()
$363
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:05 am -
1 stop6h 55m
Sat 11/146:45 am -
2 stops9h 29m
Deal found 10/13![United Airlines logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:01 pm -
2 stops17h 34m
Mon 11/231:32 pm -
1 stop7h 27m
Deal found 10/12![Multiple Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/194:01 pm -
1 stop17h 41m
Mon 11/231:32 pm -
1 stop7h 27m
Deal found 10/10![Multiple Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:00 am -
2 stops9h 45m
Tue 12/154:15 pm -
1 stop8h 30m
Deal found 10/13![Southwest logo]()
$385
Best flights from Santa Ana to KnoxvilleDiscover carefully curated flight deals from Santa Ana to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 14, 2026.
Discover carefully curated flight deals from Santa Ana to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 14, 2026.
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/102:30 pm -
1 stop6h 27m
Sun 12/135:40 am -
1 stop9h 08m
Deal found 10/13![Delta logo]()
$398
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3010:29 am -
1 stop7h 36m
Wed 2/34:28 pm -
1 stop7h 16m
Deal found 10/11![United Airlines logo]()
$483
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/202:20 pm -
1 stop6h 30m
Fri 12/257:00 am -
1 stop6h 55m
Deal found 10/11![Delta logo]()
$481
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:45 am -
1 stop7h 14m
Mon 11/235:05 pm -
1 stop7h 55m
Deal found 10/13![United Airlines logo]()
$483
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1210:20 am -
1 stop7h 27m
Mon 12/144:43 pm -
1 stop7h 26m
Deal found 10/13![United Airlines logo]()
$483
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/137:50 pm -
2 stops11h 19m
Sat 2/206:15 am -
2 stops15h 29m
Deal found 10/10![United Airlines logo]()
$543
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/156:28 pm -
2 stops12h 41m
Fri 2/1912:11 pm -
1 stop11h 10m
Deal found 10/10![United Airlines logo]()
$573
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:50 am -
1 stop6h 14m
Wed 12/26:25 am -
2 stops18h 50m
Deal found 10/14![United Airlines logo]()
$584
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:45 am -
1 stop7h 14m
Thu 10/296:45 am -
2 stops9h 29m
Deal found 10/11![United Airlines logo]()
$612
Last-minute flights from Santa Ana to KnoxvilleDiscover last-minute flight deals from Santa Ana to Knoxville. Data last updated October 14, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Ana to Knoxville. Data last updated October 14, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:26 pm -
1 stop6h 52m
Sun 11/15:30 am -
1 stop8h 33m
Deal found 10/9![American Airlines logo]()
$415
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/69:41 am -
2 stops26h 26m
Mon 11/910:09 pm -
1 stop19h 54m
Deal found 10/11![Multiple Airlines logo]()
$361
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:45 am -
1 stop6h 57m
Sat 11/145:30 am -
1 stop10h 05m
Deal found 10/13![American Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:05 am -
1 stop6h 55m
Sat 11/146:45 am -
2 stops9h 29m
Deal found 10/13![United Airlines logo]()
$368
This Southwest deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:00 am -
2 stops7h 45m
Sat 11/147:10 am -
2 stops10h 00m
Deal found 10/13![Southwest logo]()
$407
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:30 am -
2 stops26h 49m
Sun 11/158:43 pm -
1 stop25h 28m
Deal found 10/11![Multiple Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:45 am -
1 stop6h 57m
Sun 11/155:30 am -
1 stop8h 33m
Deal found 10/11![American Airlines logo]()
$398
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:01 pm -
2 stops17h 34m
Mon 11/231:32 pm -
1 stop7h 27m
Deal found 10/12![Multiple Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/194:01 pm -
1 stop17h 41m
Mon 11/231:32 pm -
1 stop7h 27m
Deal found 10/10![Multiple Airlines logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/194:01 pm -
1 stop17h 41m
Sun 11/229:49 pm -
2 stops21h 16m
Deal found 10/9![Multiple Airlines logo]()
$419
One-way flights from Santa Ana to KnoxvilleSearch for one-way flight options from Santa Ana to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 14, 2026.
Search for one-way flight options from Santa Ana to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/88:33 pm -
2 stops20h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![Multiple Airlines logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:45 am -
1 stop9h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/13![Multiple Airlines logo]()
$176
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:47 am -
1 stop7h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/13![United Airlines logo]()
$182
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/177:45 am -
1 stop7h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![American Airlines logo]()
$217
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/512:04 pm -
1 stop6h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![United Airlines logo]()
$242
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/46:45 am -
1 stop8h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![American Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:30 am -
3 stops35h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/13![Multiple Airlines logo]()
$270
Find flight deals from Santa Ana to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $305 (Kiwi.com) |
One-way from | $174 (Kiwi.com) |
Popular in | November |
Cheapest in | January |
Average price | $518 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 14, 2026.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santa AnaKnoxville
SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson
SNATYS
Santa Ana J. Wayne/Orange Cnty
Sun 11/1
7:45 am-8:39 pm
1 stop9h 54m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$176
Santa AnaKnoxville
SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson
SNATYS
Santa Ana J. Wayne/Orange Cnty
Wed 11/18
11:10 am-11:59 pm
2 stops9h 49m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$187
Santa AnaKnoxville
SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson
SNATYS
Santa Ana J. Wayne/Orange Cnty
Sun 1/17
7:45 am-6:42 pm
1 stop7h 57m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$217
Santa AnaKnoxville
SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson
SNATYS
Santa Ana J. Wayne/Orange Cnty
Tue 1/5
6:49 am-9:05 pm
2 stops11h 16m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$247
Santa AnaKnoxville
SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson
SNATYS
Santa Ana J. Wayne/Orange Cnty
Sun 1/17
9:00 am-11:59 pm
2 stops11h 59m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$282
Santa AnaKnoxville
SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson
SNATYS
Santa Ana J. Wayne/Orange Cnty
Mon 1/4
6:30 pm-10:10 am
2 stops12h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$309
Quickest round-trip
Santa AnaKnoxville
SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson
SNATYS
Santa Ana J. Wayne/Orange Cnty
Sun 11/8
1:09 pm-10:32 pm
1 stop6h 23m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$327
Santa AnaKnoxville
SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson
SNATYS
Santa Ana J. Wayne/Orange Cnty
Mon 12/28
6:27 pm-11:04 am
2 stops13h 37m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$365
Santa AnaKnoxville
SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson
SNATYS
Santa Ana J. Wayne/Orange Cnty
Thu 12/10
2:30 pm-11:57 pm
1 stop6h 27m
Knoxville McGhee Tyson
Sun 12/13
5:40 am-11:48 am
1 stop9h 08m
$398
Santa AnaKnoxville
SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson
SNATYS
Santa Ana J. Wayne/Orange Cnty
Sun 12/20
2:20 pm-11:50 pm
1 stop6h 30m
Knoxville McGhee Tyson
Fri 12/25
7:00 am-10:55 am
1 stop6h 55m
$481
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Santa Ana to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Knoxville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Santa Ana, California-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana, California-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Ana, California-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Ana to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Ana with our price prediction graph.
SNA-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santa Ana to Knoxville
How far ahead should I book a flight from Santa Ana, California to Knoxville?
Booking 57 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santa Ana, California to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Santa Ana, California to Knoxville?
Currently, January is the cheapest month in which you can book a flight from Santa Ana, California to Knoxville (average of $452). Flying from Santa Ana, California to Knoxville in November is currently the most expensive (average of $837). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santa Ana, California to Knoxville?
Airfare is below average for this route at the moment.
Santa Ana, California to Knoxville flights typically cost between $374 and $566 in December.The cheapest round-trip price found within the last 5 days was $305 on Multiple Airlines (Dec 3-Dec 7).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 14, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Santa Ana to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Food
7.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Santa Ana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Newport
Bryson City
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 14, 2026.
Santa Ana and Knoxville flights
Browse other Santa Ana and Knoxville flight options. Last updated on October 14, 2026.
Other flights from Santa Ana
Browse through other flights departing from Santa Ana. Flights are based on user searches made on Cheapflights and were last updated on October 14, 2026.
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Top 4 airlines flying from Santa Ana to Knoxville
Discover the top 4 airlines that operate flights from Santa Ana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$229 | Average$428 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$289 | Average$569 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$328 | Average$536 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$412 | Average$556 | FlexibilityNo cancel fee | On-time63% |