$115+ Cheap flights from Santa Ana to Knoxville (SNA - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/2. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — TYS
May 23 — May 301
Round-trip
1 adult, Economy
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Cheapest flights from Santa Ana to KnoxvilleExplore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
Explore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:00 pm
SNA
- TYS
1 stop6h 47m
Delta
Tue 8/255:57 pm
TYS
- SNA
1 stop7h 17m
Delta
Deal found 4/20![Delta logo]()
$277
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:30 pm
SNA
- TYS
1 stop6h 26m
American Airlines
Sat 5/305:36 am
TYS
- SNA
1 stop8h 20m
American Airlines
Deal found 4/21![American Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:00 am
SNA
- TYS
1 stop8h 31m
American Airlines
Fri 6/51:00 pm
TYS
- SNA
1 stop10h 05m
American Airlines
Deal found 4/22![American Airlines logo]()
$296
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:00 pm
SNA
- TYS
1 stop6h 47m
Delta
Tue 8/255:57 pm
TYS
- SNA
1 stop7h 17m
Delta
Deal found 4/20![Delta logo]()
$298
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/242:00 pm
SNA
- TYS
1 stop6h 56m
Delta
Thu 5/286:36 am
TYS
- SNA
1 stop9h 09m
Delta
Deal found 4/21![Delta logo]()
$313
This Trip.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:11 am
SNA
- TYS
1 stop8h 40m
Multiple Airlines
Fri 5/88:32 pm
TYS
- SNA
1 stop15h 37m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$323
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:45 am
SNA
- TYS
1 stop8h 32m
Delta
Tue 8/255:57 pm
TYS
- SNA
1 stop7h 17m
Delta
Deal found 4/20![Delta logo]()
$328
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:45 am
SNA
- TYS
1 stop12h 06m
Multiple Airlines
Mon 5/257:24 pm
TYS
- SNA
2 stops47h 14m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$337
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2910:20 am
SNA
- TYS
1 stop8h 59m
United Airlines
Fri 6/54:56 pm
TYS
- SNA
1 stop8h 05m
United Airlines
Deal found 4/22![United Airlines logo]()
$346
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:45 am
SNA
- TYS
1 stop8h 46m
American Airlines
Thu 5/285:36 am
TYS
- SNA
1 stop7h 04m
American Airlines
Deal found 4/20![American Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:14 pm
SNA
- TYS
1 stop23h 37m
Multiple Airlines
Mon 5/257:24 pm
TYS
- SNA
2 stops47h 14m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$352
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:45 am
SNA
- TYS
2 stops8h 45m
Southwest
Tue 10/271:50 pm
TYS
- SNA
1 stop8h 15m
Southwest
Deal found 4/20![Southwest logo]()
$354
Best flights from Santa Ana to KnoxvilleDiscover carefully curated flight deals from Santa Ana to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
Discover carefully curated flight deals from Santa Ana to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/242:00 pm
SNA
- TYS
1 stop6h 56m
Delta
Thu 5/286:36 am
TYS
- SNA
1 stop9h 09m
Delta
Deal found 4/21![Delta logo]()
$313
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/2410:20 am
SNA
- TYS
2 stops9h 52m
United Airlines
Thu 5/288:48 am
TYS
- SNA
1 stop9h 08m
United Airlines
Deal found 4/18![United Airlines logo]()
$454
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/137:55 pm
SNA
- TYS
2 stops13h 10m
Southwest
Wed 6/177:10 am
TYS
- SNA
2 stops10h 35m
Southwest
Deal found 4/20![Southwest logo]()
$493
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:26 pm
SNA
- TYS
2 stops13h 16m
United Airlines
Sat 5/306:02 pm
TYS
- SNA
1 stop7h 30m
United Airlines
Deal found 4/19![United Airlines logo]()
$538
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:35 am
SNA
- TYS
2 stops8h 45m
Southwest
Sun 7/124:20 pm
TYS
- SNA
2 stops8h 55m
Southwest
Deal found 4/18![Southwest logo]()
$575
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/192:00 pm
SNA
- TYS
1 stop6h 54m
Delta
Sun 6/216:05 pm
TYS
- SNA
1 stop7h 23m
Delta
Deal found 4/19![Delta logo]()
$588
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/69:00 am
SNA
- TYS
2 stops7h 40m
Southwest
Fri 5/86:35 am
TYS
- SNA
2 stops8h 20m
Southwest
Deal found 4/21![Southwest logo]()
$587
Last-minute flights from Santa Ana to KnoxvilleDiscover last-minute flight deals from Santa Ana to Knoxville. Data last updated April 23, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Ana to Knoxville. Data last updated April 23, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:11 am
SNA
- TYS
1 stop8h 40m
Multiple Airlines
Fri 5/88:32 pm
TYS
- SNA
1 stop15h 37m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:14 pm
SNA
- TYS
1 stop23h 37m
Multiple Airlines
Mon 5/257:24 pm
TYS
- SNA
2 stops47h 14m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$352
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:14 pm
SNA
- TYS
1 stop23h 37m
Multiple Airlines
Fri 5/2210:03 pm
TYS
- SNA
2 stops39h 16m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:45 am
SNA
- TYS
1 stop12h 06m
Multiple Airlines
Mon 5/257:24 pm
TYS
- SNA
2 stops47h 14m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:45 am
SNA
- TYS
1 stop12h 06m
Multiple Airlines
Sat 5/2312:54 pm
TYS
- SNA
2 stops24h 25m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$386
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2211:14 am
SNA
- TYS
2 stops19h 48m
Multiple Airlines
Thu 5/287:00 am
TYS
- SNA
1 stop29h 09m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/242:00 pm
SNA
- TYS
1 stop6h 56m
Delta
Thu 5/286:36 am
TYS
- SNA
1 stop9h 09m
Delta
Deal found 4/21![Delta logo]()
$313
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:45 am
SNA
- TYS
1 stop8h 46m
American Airlines
Thu 5/285:36 am
TYS
- SNA
1 stop7h 04m
American Airlines
Deal found 4/20![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:30 pm
SNA
- TYS
1 stop6h 26m
American Airlines
Sat 5/305:36 am
TYS
- SNA
1 stop8h 20m
American Airlines
Deal found 4/21![American Airlines logo]()
$289
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2910:20 am
SNA
- TYS
1 stop8h 59m
United Airlines
Fri 6/54:56 pm
TYS
- SNA
1 stop8h 05m
United Airlines
Deal found 4/22![United Airlines logo]()
$346
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:00 am
SNA
- TYS
1 stop8h 31m
American Airlines
Fri 6/51:00 pm
TYS
- SNA
1 stop10h 05m
American Airlines
Deal found 4/22![American Airlines logo]()
$296
One-way flights from Santa Ana to KnoxvilleSearch for one-way flight options from Santa Ana to Knoxville. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
Search for one-way flight options from Santa Ana to Knoxville. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:34 pm
SNA
- TYS
1 stop6h 44m
American Airlines
Deal found 4/21![American Airlines logo]()
$115
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:00 pm
SNA
- TYS
1 stop6h 47m
Delta
Deal found 4/21![Delta logo]()
$160
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/812:15 pm
SNA
- TYS
1 stop6h 43m
Delta
Deal found 4/19![Delta logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:55 am
SNA
- TYS
2 stops55h 20m
Allegiant Air
Deal found 4/19![Allegiant Air logo]()
$184
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/711:26 am
SNA
- TYS
1 stop7h 38m
American Airlines
Deal found 4/19![American Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:23 pm
SNA
- TYS
3 stops50h 12m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$202
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:38 pm
SNA
- TYS
3 stops45h 04m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:38 pm
SNA
- TYS
2 stops22h 47m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$219
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/78:00 am
SNA
- TYS
2 stops9h 20m
Southwest
Deal found 4/19![Southwest logo]()
$225
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:50 am
SNA
- TYS
2 stops11h 40m
United Airlines
Deal found 4/21![United Airlines logo]()
$229
Find flight deals from Santa Ana to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $277 (Delta) |
One-way from | $115 (American Airlines) |
Popular in | March |
Cheapest in | August |
Average price | $488 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santa AnaKnoxville
SNA - TYS
SNATYS
Santa Ana J. Wayne/Orange Cnty
Sun 5/24
2:00 pm-11:56 pm
1 stop6h 56m
Knoxville McGhee Tyson
Thu 5/28
6:36 am-12:45 pm
1 stop9h 09m
$313
Santa AnaKnoxville
SNA - TYS
SNATYS
Santa Ana J. Wayne/Orange Cnty
Sun 5/24
10:20 am-11:12 pm
2 stops9h 52m
Knoxville McGhee Tyson
Thu 5/28
8:48 am-2:56 pm
1 stop9h 08m
$454
Santa AnaKnoxville
SNA - TYS
SNATYS
Santa Ana J. Wayne/Orange Cnty
Sat 6/13
7:55 pm-12:05 pm
2 stops13h 10m
Knoxville McGhee Tyson
Wed 6/17
7:10 am-2:45 pm
2 stops10h 35m
$493
Santa AnaKnoxville
SNA - TYS
SNATYS
Santa Ana J. Wayne/Orange Cnty
Wed 5/27
6:26 pm-10:42 am
2 stops13h 16m
Knoxville McGhee Tyson
Sat 5/30
6:02 pm-10:32 pm
1 stop7h 30m
$538
Santa AnaKnoxville
SNA - TYS
SNATYS
Santa Ana J. Wayne/Orange Cnty
Wed 7/8
8:35 am-8:20 pm
2 stops8h 45m
Knoxville McGhee Tyson
Sun 7/12
4:20 pm-10:15 pm
2 stops8h 55m
$575
Santa AnaKnoxville
SNA - TYS
SNATYS
Santa Ana J. Wayne/Orange Cnty
Wed 5/6
9:00 am-7:40 pm
2 stops7h 40m
Knoxville McGhee Tyson
Fri 5/8
6:35 am-11:55 am
2 stops8h 20m
$587
Quickest round-trip
Santa AnaKnoxville
SNA - TYS
SNATYS
Santa Ana J. Wayne/Orange Cnty
Fri 6/19
2:00 pm-11:54 pm
1 stop6h 54m
Knoxville McGhee Tyson
Sun 6/21
6:05 pm-10:28 pm
1 stop7h 23m
$588
Cheapest one-way
Santa AnaKnoxville
SNA - TYS
SNATYS
Santa Ana J. Wayne/Orange Cnty
Fri 8/21
2:00 pm-11:47 pm
1 stop6h 47m
$160
Quickest one-way
Santa AnaKnoxville
SNA - TYS
SNATYS
Santa Ana J. Wayne/Orange Cnty
Wed 7/8
2:23 pm-11:52 pm
1 stop6h 29m
$175
Santa AnaKnoxville
SNA - TYS
SNATYS
Santa Ana J. Wayne/Orange Cnty
Wed 5/27
7:20 am-7:40 pm
2 stops9h 20m
$225
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Santa Ana to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Knoxville in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Santa Ana, California-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana, California-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Ana, California-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Ana to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Ana with our price prediction graph.
SNA-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santa Ana to Knoxville
How far ahead should I book a flight from Santa Ana, California to Knoxville?
Use this chart to determine the optimal time to book a round-trip flight from Santa Ana to Knoxville. Price data was last updated on April 17, 2026.
Booking 51 days in advance of your planned departure date is, on average, the best time to get cheap flights from Santa Ana, California to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Santa Ana, California to Knoxville?
Currently, August is the cheapest month in which you can book a flight from Santa Ana, California to Knoxville (average of $338). Flying from Santa Ana, California to Knoxville in March is currently the most expensive (average of $569). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santa Ana, California to Knoxville?
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 23, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Santa Ana to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Boarding
8.1
Comfort
7.9
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Overall
7.9
Boarding
8.1
Comfort
7.9
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Overall
7.9
Boarding
8.1
Comfort
7.9
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Overall
7.9
Boarding
8.1
Comfort
7.9
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Related info for your journey
Find useful and relevant information for your journey from Santa Ana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 23, 2026.
Santa Ana and Knoxville flights
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Top 3 airlines flying from Santa Ana to Knoxville
Discover the top 3 airlines that operate flights from Santa Ana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$380 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$442 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$288 | Average$466 | FlexibilityNo cancel fee | On-time71% |