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$415+ Cheap flights from Medford to Knoxville (MFR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — TYS
May 23 — May 301
Sat 5/23
Sat 5/30
1 adult, Economy
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Cheap flight deals from Medford to Knoxville

Cheapest flights from Medford to Knoxville
Explore the most affordable flight options available from Medford to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.

This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:26 pm
MFR
-
TYS
2 stops13h 10m
United Airlines
Tue 9/154:56 pm
TYS
-
MFR
1 stop7h 20m
United Airlines
Deal found 4/20$459
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:35 pm
MFR
-
TYS
2 stops11h 58m
United Airlines
Tue 8/255:45 am
TYS
-
MFR
2 stops15h 00m
United Airlines
Deal found 4/22$477
This Expedia deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:08 am
MFR
-
TYS
2 stops13h 48m
Alaska Airlines
Thu 5/2811:29 am
TYS
-
MFR
2 stops10h 10m
Alaska Airlines
Deal found 4/21$533
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:15 am
MFR
-
TYS
2 stops9h 05m
American Airlines
Tue 9/151:40 pm
TYS
-
MFR
2 stops12h 10m
American Airlines
Deal found 4/20$535
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:15 am
MFR
-
TYS
2 stops13h 55m
American Airlines
Thu 9/174:01 pm
TYS
-
MFR
2 stops9h 49m
American Airlines
Deal found 4/20$548
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:00 am
MFR
-
TYS
1 stop7h 53m
United Airlines
Thu 5/284:56 pm
TYS
-
MFR
1 stop7h 20m
United Airlines
Deal found 4/21$560
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:35 pm
MFR
-
TYS
2 stops11h 58m
United Airlines
Mon 8/34:56 pm
TYS
-
MFR
1 stop7h 20m
United Airlines
Deal found 4/22$626
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1912:52 pm
MFR
-
TYS
1 stop6h 31m
United Airlines
Sun 5/244:56 pm
TYS
-
MFR
1 stop7h 20m
United Airlines
Deal found 4/21$636
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:15 am
MFR
-
TYS
2 stops11h 15m
American Airlines
Sat 7/255:03 am
TYS
-
MFR
2 stops10h 47m
American Airlines
Deal found 4/18$646
This Expedia deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:08 am
MFR
-
TYS
2 stops13h 48m
Alaska Airlines
Fri 6/121:53 pm
TYS
-
MFR
2 stops13h 11m
Alaska Airlines
Deal found 4/23$651

Find flight deals from Medford to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$459
(United Airlines)

One-way from

$415
(Delta)

Popular in

January

Cheapest in

November

Average price

$544
Provider with most accurate pricing for Medford-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Medford-Knoxville McGhee Tyson flights.
Search Deals
From Medford to Knoxville McGhee Tyson
Search Deals
One-way flight from Medford to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($58 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from Medford to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 9/12

6:26 pm-10:36 am

2 stops13h 10m

Knoxville McGhee Tyson

Tue 9/15

4:56 pm-9:16 pm

1 stop7h 20m

$459

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/8

6:35 pm-9:33 am

2 stops11h 58m

Knoxville McGhee Tyson

Tue 8/25

5:45 am-5:45 pm

2 stops15h 00m

$477

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Thu 9/10

7:15 am-12:10 am

2 stops13h 55m

Knoxville McGhee Tyson

Thu 9/17

4:01 pm-10:50 pm

2 stops9h 49m

$548

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 5/23

5:00 am-3:53 pm

1 stop7h 53m

Knoxville McGhee Tyson

Thu 5/28

4:56 pm-9:16 pm

1 stop7h 20m

$560
Quickest round-trip

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 5/19

12:52 pm-10:23 pm

1 stop6h 31m

Knoxville McGhee Tyson

Sun 5/24

4:56 pm-9:16 pm

1 stop7h 20m

$636

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 7/14

6:35 pm-10:42 am

2 stops13h 07m

Knoxville McGhee Tyson

Sat 7/25

4:56 pm-9:17 pm

1 stop7h 21m

$655

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 7/28

5:00 am-3:53 pm

1 stop7h 53m

Knoxville McGhee Tyson

Mon 8/3

4:56 pm-9:16 pm

1 stop7h 20m

$671

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 5/30

5:00 am-3:53 pm

1 stop7h 53m

Knoxville McGhee Tyson

Fri 6/12

4:56 pm-9:16 pm

1 stop7h 20m

$753
Cheapest one-way

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 6/16

6:01 am-9:41 pm

2 stops12h 40m

$415
Quickest one-way

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 6/16

1:10 pm-10:19 pm

1 stop6h 09m

$488

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/21

Sorted by cheapest first

Compare providers for flights from Medford to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Medford-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Medford-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Medford to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to Knoxville

How much does it cost to fly round-trip from Medford to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 23, 2026.
See what other customers who have flown with United Airlines from Medford to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,637 reviews

Crew

8.1

Food

6.6

Comfort

7.3

Overall

7.4

Entertainment

7.1

Boarding

7.7

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.
United Airlines
7.4
Good
9,637 reviews
United Airlines
7.4
Good
9,637 reviews

Crew

8.1

Food

6.6

Comfort

7.3

Overall

7.4

Entertainment

7.1

Boarding

7.7

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.

Related info for your journey

Find useful and relevant information for your journey from Medford to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to Knoxville?

    Departing from Medford to Knoxville will take you 13h 10m. There are 2113 mi between Medford and Knoxville. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Medford to Knoxville round-trip?

    United Airlines, at $317, was found to be the cheapest airline from Medford to Knoxville.. This flight start at 42% lower than the current average price 3 months from now.

  • Can I find deals for flights from Medford to Knoxville that include hotel bookings?

    Yes. In addition to deals on Medford to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Knoxville.

  • Can I find deals for business class flights from Medford to Knoxville?

    Yes. Cheapflights offers flight deals from Medford to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Medford to Knoxville

Discover the top airline that operate flights from Medford to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$317Average$566FlexibilityNo cancel feeOn-time69%

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