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Knoxville

$373+ Cheap flights from Medford to Knoxville (MFR - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/19. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — TYS
Aug 26 — Sep 21
Wed 8/26
Wed 9/2
1 adult, Economy
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Cheap flight deals from Medford to Knoxville

Cheapest flights from Medford to Knoxville
Explore the most affordable flight options available from Medford to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 27, 2026.

This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:00 am
MFR
-
TYS
1 stop7h 54m
United Airlines
Wed 8/264:50 pm
TYS
-
MFR
1 stop7h 18m
United Airlines
Deal found 7/24$373
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2111:08 am
MFR
-
TYS
1 stop7h 38m
Multiple Airlines
Thu 8/277:00 am
TYS
-
MFR
2 stops28h 33m
Multiple Airlines
Deal found 7/25$381
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:13 am
MFR
-
TYS
2 stops14h 42m
Delta
Mon 9/285:40 am
TYS
-
MFR
2 stops10h 06m
Delta
Deal found 7/27$384
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:28 pm
MFR
-
TYS
2 stops13h 08m
Delta
Tue 8/255:22 pm
TYS
-
MFR
2 stops9h 33m
Delta
Deal found 7/27$389
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:00 am
MFR
-
TYS
1 stop7h 54m
United Airlines
Sat 9/269:00 am
TYS
-
MFR
2 stops12h 08m
United Airlines
Deal found 7/27$393
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/139:38 pm
MFR
-
TYS
1 stop13h 19m
Multiple Airlines
Thu 8/202:39 pm
TYS
-
MFR
2 stops22h 39m
Multiple Airlines
Deal found 7/24$414
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:00 am
MFR
-
TYS
1 stop7h 54m
United Airlines
Wed 8/194:50 pm
TYS
-
MFR
1 stop7h 18m
United Airlines
Deal found 7/24$419
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:13 am
MFR
-
TYS
2 stops14h 42m
Delta
Fri 9/255:28 pm
TYS
-
MFR
2 stops9h 27m
Delta
Deal found 7/27$423

Find flight deals from Medford to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$373
(United Airlines)

Popular in

October

Cheapest in

April

Average price

$875
Provider with most accurate pricing for Medford-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Medford-Knoxville McGhee Tyson flights.
Search Deals
From Medford to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($14 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 27, 2026.
Use the filters below to find and compare flights from Medford to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 8/28

1:00 pm-10:29 pm

1 stop6h 29m

Knoxville McGhee Tyson

Sat 8/29

7:00 am-6:08 pm

2 stops14h 08m

$378

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sun 8/16

6:28 pm-1:20 pm

2 stops15h 52m

Knoxville McGhee Tyson

Wed 8/26

9:00 am-5:58 pm

2 stops11h 58m

$493

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 8/21

6:28 pm-11:52 am

2 stops14h 24m

Knoxville McGhee Tyson

Wed 8/26

1:00 pm-9:08 pm

2 stops11h 08m

$493

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Wed 8/19

5:00 am-8:53 pm

2 stops12h 53m

Knoxville McGhee Tyson

Mon 8/24

4:50 pm-9:08 pm

1 stop7h 18m

$494

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sun 8/16

6:28 pm-1:20 pm

2 stops15h 52m

Knoxville McGhee Tyson

Mon 8/24

2:21 pm-10:13 pm

2 stops10h 52m

$499

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 8/21

6:28 pm-11:52 am

2 stops14h 24m

Knoxville McGhee Tyson

Mon 8/24

2:21 pm-10:13 pm

2 stops10h 52m

$499

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sun 8/16

6:28 pm-1:20 pm

2 stops15h 52m

Knoxville McGhee Tyson

Fri 8/28

9:45 am-9:08 pm

2 stops14h 23m

$499

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sun 8/16

6:15 am-6:52 pm

2 stops9h 37m

Knoxville McGhee Tyson

Sun 8/23

5:40 am-12:53 pm

2 stops10h 13m

$529

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Wed 8/12

5:00 am-3:54 pm

1 stop7h 54m

Knoxville McGhee Tyson

Sun 8/23

5:45 am-1:01 pm

2 stops10h 16m

$534

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 8/11

6:00 am-10:29 pm

2 stops13h 29m

Knoxville McGhee Tyson

Sat 8/22

9:00 am-6:08 pm

2 stops12h 08m

$539

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

Compare providers for flights from Medford to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Knoxville in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Medford-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Medford-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Medford to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 27, 2026.
See what other customers who have flown with United Airlines from Medford to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
10,041 reviews

Comfort

7.3

Entertainment

7.1

Food

6.6

Boarding

7.7

Overall

7.4

Crew

8.1

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
United Airlines
7.4
Good
10,041 reviews
United Airlines
7.4
Good
10,041 reviews

Comfort

7.3

Entertainment

7.1

Food

6.6

Boarding

7.7

Overall

7.4

Crew

8.1

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this

Related info for your journey

Find useful and relevant information for your journey from Medford to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to Knoxville?

    Departing from Medford to Knoxville will take you 6h 29m. There are 2113 mi between Medford and Knoxville.

  • What is the cheapest airline to fly from Medford to Knoxville round-trip?

    United Airlines, at $317, was found to be the cheapest airline from Medford to Knoxville.. This flight start at 52% lower than the current average price 3 months from now.

  • Can I find deals for flights from Medford to Knoxville that include hotel bookings?

    Yes. In addition to deals on Medford to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to Knoxville.

  • Can I find deals for business class flights from Medford to Knoxville?

    Yes. Cheapflights offers flight deals from Medford to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

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Top airline flying from Medford to Knoxville

Discover the top airline that operate flights from Medford to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$317Average$622FlexibilityNo cancel feeOn-time69%

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