$233+ Cheap flights from Medford to Knoxville (MFR - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — TYS
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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Find cheap flights from Medford to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Medford to Knoxville
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Best
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Cheapest flights from Medford to KnoxvilleExplore the most affordable flight options available from Medford to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Medford to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:00 am -
1 stop7h 54m
Sat 9/264:53 pm -
1 stop7h 21m
Deal found 9/6![United Airlines logo]()
$479
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:13 am -
2 stops12h 31m
Sat 9/265:40 am -
2 stops10h 06m
Deal found 9/6![Delta logo]()
$489
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:05 pm -
1 stop23h 23m
Thu 9/248:20 am -
1 stop27h 12m
Deal found 9/5![Allegiant Air logo]()
$501
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:29 pm -
2 stops13h 00m
Sat 9/1911:45 am -
2 stops14h 32m
Deal found 9/5![Delta logo]()
$579
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:05 pm -
2 stops21h 22m
Thu 9/248:20 am -
1 stop27h 12m
Deal found 9/5![Multiple Airlines logo]()
$599
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:00 am -
1 stop7h 54m
Sat 9/199:00 am -
1 stop7h 01m
Deal found 9/5![United Airlines logo]()
$639
Best flights from Medford to KnoxvilleDiscover carefully curated flight deals from Medford to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Medford to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:00 am -
1 stop7h 54m
Sat 9/264:53 pm -
1 stop7h 21m
Deal found 9/6![United Airlines logo]()
$479
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:13 am -
2 stops12h 31m
Sat 9/265:40 am -
2 stops10h 06m
Deal found 9/6![Delta logo]()
$489
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:05 pm -
1 stop23h 23m
Thu 9/248:20 am -
1 stop27h 12m
Deal found 9/5![Allegiant Air logo]()
$501
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/306:00 am -
2 stops10h 51m
Wed 2/34:25 pm -
1 stop7h 45m
Deal found 9/8![United Airlines logo]()
$528
Last-minute flights from Medford to KnoxvilleDiscover last-minute flight deals from Medford to Knoxville. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Medford to Knoxville. Data last updated September 10, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:29 pm -
2 stops13h 00m
Sat 9/1911:45 am -
2 stops14h 32m
Deal found 9/5![Delta logo]()
$579
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:00 am -
1 stop7h 54m
Sat 9/199:00 am -
1 stop7h 01m
Deal found 9/5![United Airlines logo]()
$639
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:05 pm -
1 stop23h 23m
Thu 9/248:20 am -
1 stop27h 12m
Deal found 9/5![Allegiant Air logo]()
$501
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:05 pm -
2 stops21h 22m
Thu 9/248:20 am -
1 stop27h 12m
Deal found 9/5![Multiple Airlines logo]()
$599
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:00 am -
1 stop7h 54m
Sat 9/264:53 pm -
1 stop7h 21m
Deal found 9/6![United Airlines logo]()
$479
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:13 am -
2 stops12h 31m
Sat 9/265:40 am -
2 stops10h 06m
Deal found 9/6![Delta logo]()
$489
One-way flights from Medford to KnoxvilleSearch for one-way flight options from Medford to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Medford to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:25 pm -
3 stops41h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:41 pm -
3 stops59h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$257
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:25 pm -
2 stops13h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Delta logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2510:53 am -
3 stops29h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/213:40 pm -
3 stops39h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$300
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:11 am -
2 stops14h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Delta logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:34 pm -
1 stop29h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Allegiant Air logo]()
$308
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:25 pm -
2 stops14h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Delta logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2510:53 am -
1 stop30h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Allegiant Air logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:34 pm -
3 stops19h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$361
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:08 pm -
3 stops16h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![United Airlines logo]()
$376
Find flight deals from Medford to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $393 (United Airlines) |
One-way from | $233 (Kiwi.com) |
Popular in | October |
Cheapest in | April |
Average price | $523 |
Cheapflights Fare Finder
Customize your flight search to find flights from Medford to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Medford to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Tue 10/27
6:11 am-9:37 pm
2 stops12h 26m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$294
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Sat 10/24
5:25 pm-9:34 am
2 stops13h 09m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$294
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Mon 10/26
5:25 pm-3:26 pm
2 stops19h 01m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$300
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Sun 10/25
5:25 pm-10:54 am
2 stops14h 29m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$322
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Wed 10/21
2:08 pm-9:45 am
3 stops16h 37m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$376
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Sat 10/24
2:08 pm-9:53 am
3 stops16h 45m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$376
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Tue 9/22
5:00 am-3:54 pm
1 stop7h 54m
Knoxville McGhee Tyson
Sat 9/26
4:53 pm-9:14 pm
1 stop7h 21m
$479
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Tue 9/22
6:13 am-9:44 pm
2 stops12h 31m
Knoxville McGhee Tyson
Sat 9/26
5:40 am-12:46 pm
2 stops10h 06m
$489
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Sun 9/20
1:05 pm-3:28 pm
1 stop23h 23m
Knoxville McGhee Tyson
Thu 9/24
8:20 am-8:32 am
1 stop27h 12m
$501
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Sat 1/30
6:00 am-7:51 pm
2 stops10h 51m
Knoxville McGhee Tyson
Wed 2/3
4:25 pm-9:10 pm
1 stop7h 45m
$528
Sorted by cheapest first
Compare providers for flights from Medford to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Medford-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Medford-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Medford to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Medford with our price prediction graph.
MFR-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 10, 2026.
See what other customers who have flown with United Airlines from Medford to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.3
Crew
8.1
Overall
7.4
Entertainment
7.1
Food
6.6
Boarding
7.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Comfort
7.3
Crew
8.1
Overall
7.4
Entertainment
7.1
Food
6.6
Boarding
7.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Related info for your journey
Find useful and relevant information for your journey from Medford to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
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Browse through other flights departing from Medford. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Medford to Knoxville
Discover the top airline that operate flights from Medford to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$317 | Average$569 | FlexibilityNo cancel fee | On-time69% |