$293+ Cheap flights from Medford to Knoxville (MFR - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — TYS
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from Medford to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Medford to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Medford to KnoxvilleExplore the most affordable flight options available from Medford to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from Medford to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:01 am -
1 stop8h 03m
Wed 12/24:43 pm -
1 stop7h 43m
Deal found 10/21![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:00 pm -
1 stop6h 32m
Thu 11/269:00 am -
1 stop7h 09m
Deal found 10/22![United Airlines logo]()
$502
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:00 am -
1 stop7h 49m
Tue 10/275:05 pm -
1 stop7h 13m
Deal found 10/21![United Airlines logo]()
$617
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/75:00 am -
1 stop6h 41m
Wed 12/304:55 pm -
1 stop7h 30m
Deal found 10/22![United Airlines logo]()
$660
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:04 am -
2 stops11h 30m
Thu 11/265:30 am -
2 stops14h 17m
Deal found 10/22![American Airlines logo]()
$734
Best flights from Medford to KnoxvilleDiscover carefully curated flight deals from Medford to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from Medford to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:01 am -
1 stop8h 03m
Wed 12/24:43 pm -
1 stop7h 43m
Deal found 10/21![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:00 pm -
1 stop6h 32m
Thu 11/266:00 am -
2 stops10h 09m
Deal found 10/22![United Airlines logo]()
$507
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/305:00 am -
1 stop6h 56m
Wed 2/36:15 am -
2 stops14h 58m
Deal found 10/24![United Airlines logo]()
$534
Last-minute flights from Medford to KnoxvilleDiscover last-minute flight deals from Medford to Knoxville. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from Medford to Knoxville. Data last updated October 25, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:00 am -
1 stop7h 49m
Tue 10/275:05 pm -
1 stop7h 13m
Deal found 10/21![United Airlines logo]()
$617
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:00 pm -
1 stop6h 32m
Thu 11/269:00 am -
1 stop7h 09m
Deal found 10/22![United Airlines logo]()
$502
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:04 am -
2 stops11h 30m
Thu 11/265:30 am -
2 stops14h 17m
Deal found 10/22![American Airlines logo]()
$734
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:01 am -
1 stop8h 03m
Wed 12/24:43 pm -
1 stop7h 43m
Deal found 10/21![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/275:01 am -
1 stop7h 58m
Mon 11/305:05 pm -
1 stop7h 13m
Deal found 10/23![United Airlines logo]()
$1,026
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/275:04 am -
2 stops13h 43m
Mon 11/303:47 pm -
2 stops10h 37m
Deal found 10/23![American Airlines logo]()
$1,046
One-way flights from Medford to KnoxvilleSearch for one-way flight options from Medford to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from Medford to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:04 am -
2 stops13h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Delta logo]()
$293
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:00 pm -
1 stop6h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![United Airlines logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:08 am -
3 stops37h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$684
Find flight deals from Medford to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $404 (United Airlines) |
One-way from | $293 (Delta) |
Popular in | October |
Cheapest in | April |
Average price | $912 |
Cheapflights Fare Finder
Customize your flight search to find flights from Medford to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Medford to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Mon 11/23
6:04 am-10:22 pm
2 stops13h 18m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$293
Quickest round-trip
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Mon 11/23
1:00 pm-10:32 pm
1 stop6h 32m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$389
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Tue 11/24
5:01 am-4:04 pm
1 stop8h 03m
Knoxville McGhee Tyson
Wed 12/2
4:43 pm-9:26 pm
1 stop7h 43m
$439
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Thu 11/19
1:00 pm-10:32 pm
1 stop6h 32m
Knoxville McGhee Tyson
Thu 11/26
6:00 am-1:09 pm
2 stops10h 09m
$507
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Sat 1/30
5:00 am-2:56 pm
1 stop6h 56m
Knoxville McGhee Tyson
Wed 2/3
6:15 am-6:13 pm
2 stops14h 58m
$534
MedfordKnoxville
MFR Medford - TYS Knoxville McGhee Tyson
MFRTYS
Medford
Mon 11/23
5:08 am-10:06 pm
3 stops37h 58m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$684
Sorted by cheapest first
Compare providers for flights from Medford to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to Knoxville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Medford-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Medford-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Medford to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Medford with our price prediction graph.
MFR-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 25, 2026.
See what other customers who have flown with United Airlines from Medford to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.3
Boarding
7.7
Food
6.7
Crew
8.1
Comfort
7.3
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Overall
7.3
Boarding
7.7
Food
6.7
Crew
8.1
Comfort
7.3
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Medford to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Newport
Bryson City
Murphy
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Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Medford to Knoxville
Discover the top airline that operate flights from Medford to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$357 | Average$577 | FlexibilityNo cancel fee | On-time69% |