$241+ Cheap flights from Knoxville to Medford (TYS - MFR)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/5. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MFR
Nov 23 — Nov 301
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Medford with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Medford
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MedfordExplore the most affordable flight options available from Knoxville to Medford. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
Explore the most affordable flight options available from Knoxville to Medford. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/184:55 pm -
1 stop7h 30m
Tue 1/126:00 am -
2 stops14h 59m
Deal found 10/22![United Airlines logo]()
$480
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1811:49 am -
2 stops14h 47m
Tue 1/125:21 pm -
2 stops12h 51m
Deal found 10/23![Delta logo]()
$509
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:38 pm -
2 stops11h 40m
Tue 10/276:11 am -
2 stops12h 26m
Deal found 10/20![Delta logo]()
$627
Best flights from Knoxville to MedfordDiscover carefully curated flight deals from Knoxville to Medford that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
Discover carefully curated flight deals from Knoxville to Medford that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/184:55 pm -
1 stop7h 30m
Tue 1/126:00 am -
2 stops14h 59m
Deal found 10/22![United Airlines logo]()
$480
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1811:49 am -
2 stops14h 47m
Tue 1/125:21 pm -
2 stops12h 51m
Deal found 10/23![Delta logo]()
$509
Last-minute flights from Knoxville to MedfordDiscover last-minute flight deals from Knoxville to Medford. Data last updated October 24, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Medford. Data last updated October 24, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:38 pm -
2 stops11h 40m
Tue 10/276:11 am -
2 stops12h 26m
Deal found 10/20![Delta logo]()
$627
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:00 am -
1 stop7h 02m
Tue 10/271:00 pm -
1 stop6h 32m
Deal found 10/21![United Airlines logo]()
$747
One-way flights from Knoxville to MedfordSearch for one-way flight options from Knoxville to Medford. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
Search for one-way flight options from Knoxville to Medford. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:33 pm -
1 stop20h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Allegiant Air logo]()
$241
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:40 am -
2 stops10h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Delta logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:30 am -
3 stops35h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$332
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/299:55 pm -
1 stop20h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Allegiant Air logo]()
$421
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/299:55 pm -
2 stops25h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$492
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/305:40 pm -
2 stops29h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![United Airlines logo]()
$632
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/302:50 pm -
3 stops21h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$634
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2612:56 pm -
3 stops38h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$677
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/269:00 am -
1 stop7h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![United Airlines logo]()
$804
Find flight deals from Knoxville to Medford
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Medford (MFR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $404 (United Airlines) |
One-way from | $241 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Medford that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
Use the filters below to find and compare flights from Knoxville to Medford that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Thu 11/26
5:40 am-12:51 pm
2 stops10h 11m
Medford
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$303
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Thu 11/5
6:30 am-3:21 pm
3 stops35h 51m
Medford
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$332
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Fri 12/18
4:55 pm-9:25 pm
1 stop7h 30m
Medford
Tue 1/12
6:00 am-11:59 pm
2 stops14h 59m
$480
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Fri 12/18
11:49 am-11:36 pm
2 stops14h 47m
Medford
Tue 1/12
5:21 pm-9:12 am
2 stops12h 51m
$509
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Mon 11/30
5:40 pm-8:13 pm
2 stops29h 33m
Medford
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$632
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Thu 11/26
12:56 pm-11:59 pm
3 stops38h 03m
Medford
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$677
Quickest round-trip
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Thu 11/26
9:00 am-1:09 pm
1 stop7h 09m
Medford
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$804
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Sun 11/29
2:54 pm-11:24 pm
2 stops11h 30m
Medford
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$1,059
Sorted by cheapest first
Compare providers for flights from Knoxville to Medford
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Medford in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Medford flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Medford flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Medford flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Medford flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Medford flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Medford
Have a flexible travel schedule? Discover the best time to fly to Medford from Knoxville with our price prediction graph.
TYS-MFR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Medford
Get insights into the airlines that provide service to Medford. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Medford. Reviews last updated October 24, 2026.
Read reviews from past customers who have flown United Airlines from Knoxville to Medford. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Entertainment
7.1
Overall
7.3
Comfort
7.3
Food
6.7
Boarding
7.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Crew
8.1
Entertainment
7.1
Overall
7.3
Comfort
7.3
Food
6.7
Boarding
7.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Medford. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Medford?
Book flights to Medford if you plan to visit one of these locationsYreka
Ashland
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Top airline flying from Knoxville to Medford
Discover the top airline that operate flights from Knoxville to Medford. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$323 | Average$733 | FlexibilityNo cancel fee | On-time69% |