$264+ Cheap flights from Knoxville to Medford (TYS - MFR)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MFR
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Medford with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Medford
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to MedfordExplore the most affordable flight options available from Knoxville to Medford. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Knoxville to Medford. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:40 am -
2 stops10h 00m
Tue 10/275:25 pm -
2 stops13h 09m
Deal found 9/9![Delta logo]()
$393
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:00 am -
1 stop7h 10m
Wed 11/111:00 pm -
1 stop6h 32m
Deal found 9/9![United Airlines logo]()
$477
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:42 am -
2 stops15h 05m
Tue 10/275:01 am -
1 stop7h 00m
Deal found 9/9![United Airlines logo]()
$488
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2312:15 pm -
2 stops13h 30m
Sun 9/275:00 am -
1 stop7h 49m
Deal found 9/8![United Airlines logo]()
$501
Best flights from Knoxville to MedfordDiscover carefully curated flight deals from Knoxville to Medford that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Knoxville to Medford that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:40 am -
2 stops10h 00m
Tue 10/275:25 pm -
2 stops13h 09m
Deal found 9/9![Delta logo]()
$393
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:00 am -
1 stop7h 10m
Wed 11/111:00 pm -
1 stop6h 32m
Deal found 9/9![United Airlines logo]()
$477
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2312:15 pm -
2 stops13h 30m
Sun 9/275:00 am -
1 stop7h 49m
Deal found 9/8![United Airlines logo]()
$501
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:42 am -
2 stops15h 05m
Tue 10/275:01 am -
1 stop7h 00m
Deal found 9/6![United Airlines logo]()
$508
Last-minute flights from Knoxville to MedfordDiscover last-minute flight deals from Knoxville to Medford. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Medford. Data last updated September 10, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2312:15 pm -
2 stops13h 30m
Sun 9/275:00 am -
1 stop7h 49m
Deal found 9/8![United Airlines logo]()
$501
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:40 am -
2 stops10h 06m
Sun 9/275:29 pm -
2 stops14h 49m
Deal found 9/8![Delta logo]()
$617
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:40 am -
2 stops10h 00m
Tue 10/275:25 pm -
2 stops13h 09m
Deal found 9/9![Delta logo]()
$393
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:42 am -
2 stops15h 05m
Tue 10/275:01 am -
1 stop7h 00m
Deal found 9/9![United Airlines logo]()
$488
One-way flights from Knoxville to MedfordSearch for one-way flight options from Knoxville to Medford. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Knoxville to Medford. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:04 pm -
3 stops47h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$264
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:40 am -
2 stops10h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Delta logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:28 am -
3 stops32h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$310
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:53 pm -
1 stop7h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/134:53 pm -
1 stop7h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$1,332
Find flight deals from Knoxville to Medford
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Medford (MFR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $393 (Delta) |
One-way from | $264 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Medford that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Knoxville to Medford that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Wed 10/7
5:40 am-12:40 pm
2 stops10h 00m
Medford
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$294
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Tue 10/13
7:09 am-4:45 pm
2 stops12h 36m
Medford
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$294
Quickest round-trip
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Wed 10/7
4:53 pm-9:14 pm
1 stop7h 21m
Medford
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$389
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Fri 10/23
5:40 am-12:40 pm
2 stops10h 00m
Medford
Tue 10/27
5:25 pm-9:34 am
2 stops13h 09m
$393
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Sat 11/7
9:00 am-1:10 pm
1 stop7h 10m
Medford
Wed 11/11
1:00 pm-10:32 pm
1 stop6h 32m
$477
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Wed 9/23
12:15 pm-10:45 pm
2 stops13h 30m
Medford
Sun 9/27
5:00 am-3:49 pm
1 stop7h 49m
$501
KnoxvilleMedford
TYS Knoxville McGhee Tyson - MFR Medford
TYSMFR
Knoxville McGhee Tyson
Fri 10/23
10:42 am-10:47 pm
2 stops15h 05m
Medford
Tue 10/27
5:01 am-3:01 pm
1 stop7h 00m
$508
Sorted by cheapest first
Compare providers for flights from Knoxville to Medford
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Medford in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Medford flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Medford flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Medford flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Medford flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Medford flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Medford
Have a flexible travel schedule? Discover the best time to fly to Medford from Knoxville with our price prediction graph.
TYS-MFR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Medford
Get insights into the airlines that provide service to Medford. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Medford. Reviews last updated September 10, 2026.
Read reviews from past customers who have flown United Airlines from Knoxville to Medford. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Boarding
7.7
Food
6.7
Comfort
7.3
Entertainment
7.1
Overall
7.4
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Crew
8.1
Boarding
7.7
Food
6.7
Comfort
7.3
Entertainment
7.1
Overall
7.4
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Medford. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Medford?
Book flights to Medford if you plan to visit one of these locationsYreka
Ashland
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Top airline flying from Knoxville to Medford
Discover the top airline that operate flights from Knoxville to Medford. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$323 | Average$733 | FlexibilityNo cancel fee | On-time69% |