$285+ Cheap flights from Madison to Knoxville (MSN - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
MSN — TYS
Nov 23 — Nov 301
Round-trip
1 adult, Economy
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Find cheap flights from Madison to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Madison to Knoxville
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Best
Last-minute
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Cheapest flights from Madison to KnoxvilleExplore the most affordable flight options available from Madison to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
Explore the most affordable flight options available from Madison to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:23 pm -
1 stop5h 21m
Sat 11/214:32 pm -
1 stop4h 29m
Deal found 10/19![American Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:29 pm -
1 stop4h 30m
Fri 11/276:14 pm -
1 stop5h 12m
Deal found 10/20![American Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:30 pm -
1 stop4h 29m
Thu 11/2611:34 am -
1 stop5h 46m
Deal found 10/19![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:38 pm -
1 stop4h 20m
Mon 11/168:52 pm -
1 stop3h 51m
Deal found 10/23![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:05 pm -
1 stop3h 54m
Thu 11/266:50 am -
1 stop6h 03m
Deal found 10/21![American Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:24 pm -
1 stop7h 25m
Tue 11/36:48 am -
1 stop6h 05m
Deal found 10/20![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1912:20 pm -
1 stop6h 14m
Thu 11/266:50 am -
1 stop6h 03m
Deal found 10/21![American Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:00 am -
1 stop4h 07m
Wed 11/116:45 am -
1 stop6h 10m
Deal found 10/23![United Airlines logo]()
$469
Best flights from Madison to KnoxvilleDiscover carefully curated flight deals from Madison to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
Discover carefully curated flight deals from Madison to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/301:32 pm -
1 stop6h 33m
Wed 2/31:55 pm -
1 stop3h 51m
Deal found 10/23![United Airlines logo]()
$435
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:00 am -
1 stop4h 55m
Thu 11/126:07 pm -
1 stop6h 52m
Deal found 10/23![American Airlines logo]()
$469
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/189:55 am -
1 stop5h 54m
Tue 12/224:52 pm -
1 stop5h 41m
Deal found 10/19![Delta logo]()
$524
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/88:15 am -
1 stop3h 58m
Thu 11/126:45 am -
1 stop4h 16m
Deal found 10/24![United Airlines logo]()
$569
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/185:24 am -
1 stop6h 10m
Mon 12/216:38 am -
2 stops7h 44m
Deal found 10/19![American Airlines logo]()
$654
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:00 pm -
1 stop4h 54m
Sat 11/285:40 pm -
1 stop6h 27m
Deal found 10/21![United Airlines logo]()
$628
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/283:00 pm -
2 stops8h 15m
Mon 1/45:57 pm -
1 stop4h 44m
Deal found 10/19![United Airlines logo]()
$646
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/243:40 pm -
1 stop4h 42m
Sat 3/271:50 pm -
1 stop6h 10m
Deal found 10/23![United Airlines logo]()
$658
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:00 am -
2 stops9h 52m
Fri 11/276:45 am -
1 stop4h 16m
Deal found 10/21![United Airlines logo]()
$671
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:00 am -
1 stop4h 07m
Sat 11/285:40 pm -
1 stop6h 27m
Deal found 10/24![United Airlines logo]()
$689
Last-minute flights from Madison to KnoxvilleDiscover last-minute flight deals from Madison to Knoxville. Data last updated October 24, 2026 and is based on user searches.
Discover last-minute flight deals from Madison to Knoxville. Data last updated October 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:05 pm -
1 stop3h 54m
Thu 11/266:50 am -
1 stop6h 03m
Deal found 10/21![American Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:24 pm -
1 stop7h 25m
Tue 11/36:48 am -
1 stop6h 05m
Deal found 10/20![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:00 am -
1 stop4h 07m
Wed 11/116:45 am -
1 stop6h 10m
Deal found 10/23![United Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:38 pm -
1 stop4h 20m
Mon 11/168:52 pm -
1 stop3h 51m
Deal found 10/23![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:23 pm -
1 stop5h 21m
Sat 11/214:32 pm -
1 stop4h 29m
Deal found 10/19![American Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1912:20 pm -
1 stop6h 14m
Thu 11/266:50 am -
1 stop6h 03m
Deal found 10/21![American Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:29 pm -
1 stop4h 30m
Fri 11/276:14 pm -
1 stop5h 12m
Deal found 10/20![American Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:30 pm -
1 stop4h 29m
Thu 11/2611:34 am -
1 stop5h 46m
Deal found 10/19![American Airlines logo]()
$339
One-way flights from Madison to KnoxvilleSearch for one-way flight options from Madison to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
Search for one-way flight options from Madison to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:15 am -
1 stop6h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![American Airlines logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:00 pm -
3 stops24h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$621
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:00 am -
2 stops8h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![United Airlines logo]()
$697
Find flight deals from Madison to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Madison (MSN) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $335 (American Airlines) |
One-way from | $285 (American Airlines) |
Popular in | February |
Cheapest in | March |
Average price | $470 |
Cheapflights Fare Finder
Customize your flight search to find flights from Madison to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
Use the filters below to find and compare flights from Madison to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
MadisonKnoxville
MSN Madison Truax Field - TYS Knoxville McGhee Tyson
MSNTYS
Madison Truax Field
Sun 11/1
6:15 am-1:17 pm
1 stop6h 02m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$285
MadisonKnoxville
MSN Madison Truax Field - TYS Knoxville McGhee Tyson
MSNTYS
Madison Truax Field
Sat 1/30
1:32 pm-9:05 pm
1 stop6h 33m
Knoxville McGhee Tyson
Wed 2/3
1:55 pm-4:46 pm
1 stop3h 51m
$435
MadisonKnoxville
MSN Madison Truax Field - TYS Knoxville McGhee Tyson
MSNTYS
Madison Truax Field
Sun 11/8
5:00 am-10:55 am
1 stop4h 55m
Knoxville McGhee Tyson
Thu 11/12
6:07 pm-11:59 pm
1 stop6h 52m
$469
MadisonKnoxville
MSN Madison Truax Field - TYS Knoxville McGhee Tyson
MSNTYS
Madison Truax Field
Fri 12/18
9:55 am-4:49 pm
1 stop5h 54m
Knoxville McGhee Tyson
Tue 12/22
4:52 pm-9:33 pm
1 stop5h 41m
$524
MadisonKnoxville
MSN Madison Truax Field - TYS Knoxville McGhee Tyson
MSNTYS
Madison Truax Field
Sun 11/8
8:15 am-1:13 pm
1 stop3h 58m
Knoxville McGhee Tyson
Thu 11/12
6:45 am-10:01 am
1 stop4h 16m
$569
MadisonKnoxville
MSN Madison Truax Field - TYS Knoxville McGhee Tyson
MSNTYS
Madison Truax Field
Mon 11/23
3:00 pm-8:54 pm
1 stop4h 54m
Knoxville McGhee Tyson
Sat 11/28
5:40 pm-11:07 pm
1 stop6h 27m
$628
MadisonKnoxville
MSN Madison Truax Field - TYS Knoxville McGhee Tyson
MSNTYS
Madison Truax Field
Mon 12/28
3:00 pm-12:15 am
2 stops8h 15m
Knoxville McGhee Tyson
Mon 1/4
5:57 pm-9:41 pm
1 stop4h 44m
$646
MadisonKnoxville
MSN Madison Truax Field - TYS Knoxville McGhee Tyson
MSNTYS
Madison Truax Field
Fri 12/18
5:24 am-12:34 pm
1 stop6h 10m
Knoxville McGhee Tyson
Mon 12/21
6:38 am-1:22 pm
2 stops7h 44m
$654
MadisonKnoxville
MSN Madison Truax Field - TYS Knoxville McGhee Tyson
MSNTYS
Madison Truax Field
Wed 3/24
3:40 pm-9:22 pm
1 stop4h 42m
Knoxville McGhee Tyson
Sat 3/27
1:50 pm-7:00 pm
1 stop6h 10m
$658
MadisonKnoxville
MSN Madison Truax Field - TYS Knoxville McGhee Tyson
MSNTYS
Madison Truax Field
Sat 11/21
5:00 am-3:52 pm
2 stops9h 52m
Knoxville McGhee Tyson
Fri 11/27
6:45 am-10:01 am
1 stop4h 16m
$671
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Madison to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Madison to Knoxville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Madison-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Madison-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Madison-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Madison-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Madison-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Madison to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Madison with our price prediction graph.
MSN-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Madison to Knoxville
What is the cheapest month to book a flight from Madison to Knoxville?
Currently, March is the cheapest month in which you can book a flight from Madison to Knoxville (average of $326). Flying from Madison to Knoxville in February is currently the most expensive (average of $533). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Madison to Knoxville?
Airfare is typical for this route at the moment.
Madison to Knoxville flights typically cost between $322 and $476 in November.The cheapest round-trip price found within the last 5 days was $335 on American Airlines (Nov 18-Nov 21).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 24, 2026.
Read through reviews of airlines operating flights from Madison to Knoxville, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Madison to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Newport
Bryson City
Murphy
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 24, 2026.
Madison and Knoxville flights
Browse other Madison and Knoxville flight options. Last updated on October 24, 2026.
Other flights from Madison
Browse through other flights departing from Madison. Flights are based on user searches made on Cheapflights and were last updated on October 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Madison to Knoxville
Discover the top 3 airlines that operate flights from Madison to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$249 | Average$333 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$299 | Average$428 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$310 | Average$420 | FlexibilityNo cancel fee | On-time69% |