HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$259+ Cheap flights from Greenville, NC to Knoxville (PGV - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/5. Fares are subject to change and may not be available on all flights or dates of travel.
PGV — TYS
Mar 7 — Mar 141
Sat 3/7
Sat 3/14
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Greenville to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Greenville to Knoxville

Cheapest flights from Greenville to Knoxville
Explore the most affordable flight options available from Greenville to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.

This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:00 am
PGV
-
TYS
1 stop3h 53m
American Airlines
Sat 2/217:02 am
TYS
-
PGV
1 stop3h 38m
American Airlines
Deal found 2/2$407

Find flight deals from Greenville to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (PGV) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$407
(American Airlines)

One-way from

$259
(American Airlines)
Provider with most accurate pricing for Pitt-Greenville-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Pitt-Greenville-Knoxville McGhee Tyson flights.
Search Deals
From Pitt-Greenville to Knoxville McGhee Tyson
Search Deals
One-way flight from Pitt-Greenville to Knoxville McGhee Tyson
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Greenville to Knoxville that are best for you.

Fly from

Greenville

Fly to

Knoxville

Route

Depart

Return

Price

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Tue 2/17

6:00 am-9:53 am

1 stop3h 53m

Knoxville McGhee Tyson

Sat 2/21

7:02 am-10:40 am

1 stop3h 38m

$407

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Thu 3/5

5:05 am-8:42 am

1 stop3h 37m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/3

Compare providers for flights from Greenville to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Knoxville in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville, North Carolina-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville, North Carolina-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville, North Carolina-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville, North Carolina-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville, North Carolina-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Knoxville

What is the cheapest month to book a flight from Greenville, North Carolina to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Greenville, North Carolina to Knoxville (average of $113). Flying from Greenville, North Carolina to Knoxville in June is currently the most expensive (average of $250). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville, North Carolina to Knoxville?

    For as low as $407, American Airlines can have you in Knoxville from Greenville, North Carolina in 3h 53m. The distance from Greenville, North Carolina to Knoxville is about 371 mi.

  • Can I find deals for flights from Greenville to Knoxville that include hotel bookings?

    Yes. In addition to deals on Greenville to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Knoxville.

  • Can I find deals for business class flights from Greenville to Knoxville?

    Yes. Cheapflights offers flight deals from Greenville to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville, North Carolina to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Greenville, North Carolina to Knoxville (average of $113). Flying from Greenville, North Carolina to Knoxville in June is currently the most expensive (average of $250). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.