What are the cheapest airlines flying from St. Louis to Knoxville round-trip?

According to our current data, Delta ($309), and American Airlines ($376) offers the cheapest pricing from St. Louis to Knoxville. Delta is priced at 36% lower than the current average price of a flight leaving 3 months from now.

Can I find flights from St. Louis to Knoxville for under $300 on Cheapflights?

Yes, there are multiple flights from St. Louis to Knoxville for under $300. The cheapest flight booked recently is on Multiple Airlines for just $270, but on average you can expect to pay $366.

Are there last-minute flights available from St. Louis to Knoxville for under $400?

There are currently 5+ open flights from St. Louis to Knoxville within the next 7 days for less than $400.

Which airlines flying from Lambert-St Louis to Knoxville McGhee Tyson have flexible cancellations due to COVID-19?

Some of our airline partners flying from Lambert-St Louis to Knoxville McGhee Tyson have new flexible policies in place due to COVID-19. American Airlines and Delta are some of the carriers where you may find flexible cancellation policies. You can use our site to filter for airlines like American Airlines with this kind of flexibility.

What is the cheapest day to fly round-trip from St. Louis to Knoxville?

Monday is generally a great day to depart. Flying on this day could help you save up to 72%.

How far in advance should I book a flight from St. Louis to Knoxville?

Find a great deal and save up to 45% by booking at least 61 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from St. Louis to Knoxville within the next two weeks, with the cheapest ticket starting at $527.

What is the cheapest month to fly from St. Louis to Knoxville?

February is one of the best times of the year to fly to Knoxville from St. Louis. Prices for February average $487 per person but you can even find prices for as low as $278. The most expensive prices can be found in the month of October. Opting for a February flight can save you 68% on your journey compared to booking in October

When is the cheapest time to fly from St. Louis to Knoxville (STL - TYS)?

When flying from St. Louis to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 38% versus a flight at noon.

What does STL to TYS mean?

Great question - STL to TYS just means Lambert-St Louis Airport to Knoxville McGhee Tyson Airport. Now you’ll know what these unique codes when you look for flights!

Flights from St. Louis, MO to Knoxville, TN from $129

How to find the cheapest flight from St. Louis (STL) to Knoxville (TYS)

Popular in	October
Cheapest in	February
Round-trip from	$306
One-way from	$160

High demand for flights, 41% potential price rise

Search Deals

Best time to find cheap flights, 23% potential price drop

Search Deals

From Lambert-St Louis to Knoxville McGhee Tyson

Search Deals

One-way flight from Lambert-St Louis to Knoxville McGhee Tyson

Search Deals

STL - TYS Price	$306 - $520
TYS Temperature	39.2 - 78.8 °F
TYS Rainfall	2.7 - 4.8 inches

STL - TYS

Price

$306 - $520

TYS

Temperature

39.2 - 78.8 °F

TYS

Rainfall

2.7 - 4.8 inches

Cheap flights from St. Louis to Knoxville in June, July 2023

The lowest fares we've come across on flights traveling from St. Louis to Knoxville in June and July 2023. Check back soon for alternative fares.

Jun 9 - Jun 11

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

27h 17m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

25h 07m

$330

Multiple Airlines

Deal found 5/31

Jun 9 - Jun 11

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

27h 17m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

17h 28m

$334

Multiple Airlines

Deal found 5/31

Jun 14 - Jun 18

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

2 stops

34h 08m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

16h 29m

$353

Multiple Airlines

Deal found 5/31

Jun 14 - Jun 18

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

3 stops

54h 01m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

24h 52m

$370

Multiple Airlines

Deal found 5/31

Jun 14 - Jun 18

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

7h 22m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

27h 03m

$400

Multiple Airlines

Deal found 5/31

Jun 13 - Jun 20

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

4h 07m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

4h 20m

$416

American Airlines

Deal found 5/30

Jun 14 - Jun 17

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

7h 22m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

38h 52m

$417

Multiple Airlines

Deal found 6/1

Jun 13 - Jun 20

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

4h 07m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

7h 31m

$421

American Airlines

Deal found 5/30

Jun 14 - Jun 17

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

7h 22m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

3 stops

49h 47m

$423

Multiple Airlines

Deal found 6/1

St. Louis to Knoxville 2023 flight deals

The lowest fares we've come across on flights traveling from St. Louis to Knoxville in June and July 2023. Check back soon for alternative fares.

Sep 2 - Sep 5

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

15h 02m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

3 stops

48h 45m

$270

Multiple Airlines

Deal found 5/31

Aug 16 - Aug 18

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

15h 32m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

27h 54m

$308

Multiple Airlines

Deal found 5/31

Sep 2 - Sep 5

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

5h 28m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

3h 26m

$309

Delta

Deal found 5/31

Jun 9 - Jun 11

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

27h 17m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

25h 07m

$330

Multiple Airlines

Deal found 5/31

Jun 9 - Jun 11

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

27h 17m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

17h 28m

$334

Multiple Airlines

Deal found 5/31

Sep 2 - Sep 5

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

15h 02m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

26h 43m

$342

Multiple Airlines

Deal found 5/31

Jul 11 - Jul 18

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

24h 41m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

21h 46m

$349

Multiple Airlines

Deal found 5/31

Jul 11 - Jul 18

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

3 stops

24h 37m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

21h 46m

$351

Multiple Airlines

Deal found 5/31

Jun 14 - Jun 18

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

2 stops

34h 08m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

16h 29m

$353

Multiple Airlines

Deal found 5/31

Cheap American Airlines flights from St. Louis to Knoxville

Take a peek at the cheapest American Airlines flights we've detected traveling from St. Louis to Knoxville. Come back soon if you're not finding the exact deal you're looking for.

Jul 2 - Jul 5

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

4h 07m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

4h 19m

$376

American Airlines

Deal found 5/31

Aug 26 - Aug 29

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

2 stops

6h 42m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

4h 32m

$377

American Airlines

Deal found 5/31

Jul 2 - Jul 5

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

4h 07m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

9h 22m

$381

American Airlines

Deal found 5/31

Jul 18 - Jul 23

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

5h 51m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

5h 07m

$396

American Airlines

Deal found 5/31

Jul 30 - Aug 5

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

4h 04m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

9h 38m

$401

American Airlines

Deal found 5/31

Jun 13 - Jun 20

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

4h 07m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

4h 20m

$416

American Airlines

Deal found 5/30

Jun 13 - Jun 20

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

4h 07m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

7h 31m

$421

American Airlines

Deal found 5/30

Nov 3 - Nov 5

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

3h 31m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

10h 15m

$422

American Airlines

Deal found 5/31

Nov 3 - Nov 5

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

2 stops

9h 16m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

10h 15m

$428

American Airlines

Deal found 5/31

Cheap Delta flights from St. Louis to Knoxville

Have a look at some of the cheapest available Delta flights departing from St. Louis and landing in Knoxville. Deals are refreshing constantly so come back soon for more options.

Sep 2 - Sep 5

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

5h 28m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

3h 26m

$309

Delta

Deal found 5/31

Jul 20 - Jul 23

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

5h 17m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

6h 24m

$419

Delta

Deal found 5/31

Last minute flights from St. Louis to Knoxville

Check out these flights departing soon from St. Louis to Knoxville. Users should examine the flight details to ensure there are no surprises.

Jun 9 - Jun 11

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

27h 17m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

25h 07m

$330

Multiple Airlines

Deal found 5/31

Jun 9 - Jun 11

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

27h 17m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

1 stop

17h 28m

$334

Multiple Airlines

Deal found 5/31

Jun 9 - Jun 11

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

3 stops

51h 57m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

25h 07m

$516

Multiple Airlines

Deal found 5/31

Jun 9 - Jun 11

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

2 stops

23h 49m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

2 stops

25h 07m

$518

Multiple Airlines

Deal found 5/31

Jun 9 - Jun 11

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

3 stops

21h 07m

TYS

Knoxville McGhee Tyson

STL

Lambert-St Louis

3 stops

22h 55m

$694

Multiple Airlines

Deal found 5/31

One-way flights to Knoxville from St. Louis

Take a look at some of the best available options we've come across on one-way flights from St. Louis to Knoxville. Those seeking round-trip flights from St. Louis to Knoxville should utilize the search form at the the top of the page.

Sep 17

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

2 stops

20h 53m

$129

Multiple Airlines

Deal found 5/31

Sep 17

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

8h 45m

$160

Multiple Airlines

Deal found 5/31

Jun 26

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

2 stops

25h 59m

$161

Multiple Airlines

Deal found 5/31

Jun 26

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

3 stops

34h 06m

$179

Multiple Airlines

Deal found 5/31

Jun 7

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

17h 05m

$202

Multiple Airlines

Deal found 6/1

Jun 7

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

17h 05m

$212

Multiple Airlines

Deal found 5/31

Jun 26

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

1 stop

4h 21m

$248

American Airlines

Deal found 5/31

Jun 7

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

2 stops

19h 59m

$257

Multiple Airlines

Deal found 5/30

Sep 17

STL

Lambert-St Louis

TYS

Knoxville McGhee Tyson

3 stops

34h 32m

$286

Multiple Airlines

Deal found 5/31

Find flights from St. Louis to Knoxville within your budget

Fly from

Fly to

Budget

$270 - $419

Route

Depart

Return

Price

Lambert-St LouisKnoxville McGhee Tyson

STL - TYS

STLTYS

Lambert-St Louis

Sat 9/2

1 stop15h 02m

Knoxville McGhee Tyson

Tue 9/5

3 stops48h 45m

$270

Pick Dates

Lambert-St LouisKnoxville McGhee Tyson

STL - TYS

STLTYS

Lambert-St Louis

Wed 8/16

1 stop15h 32m

Knoxville McGhee Tyson

Fri 8/18

2 stops27h 54m

$308

Pick Dates

Lambert-St LouisKnoxville McGhee Tyson

STL - TYS

STLTYS

Lambert-St Louis

Sat 9/2

1 stop5h 28m

Knoxville McGhee Tyson

Tue 9/5

1 stop3h 26m

$309

Pick Dates

Lambert-St LouisKnoxville McGhee Tyson

STL - TYS

STLTYS

Lambert-St Louis

Sat 9/2

1 stop15h 02m

Knoxville McGhee Tyson

Tue 9/5

2 stops26h 43m

$342

Pick Dates

Lambert-St LouisKnoxville McGhee Tyson

STL - TYS

STLTYS

Lambert-St Louis

Tue 7/11

1 stop24h 41m

Knoxville McGhee Tyson

Tue 7/18

2 stops21h 46m

$349

Pick Dates

Lambert-St LouisKnoxville McGhee Tyson

STL - TYS

STLTYS

Lambert-St Louis

Sun 7/2

1 stop4h 07m

Knoxville McGhee Tyson

Wed 7/5

1 stop4h 19m

$376

Pick Dates

Lambert-St LouisKnoxville McGhee Tyson

STL - TYS

STLTYS

Lambert-St Louis

Sat 8/26

2 stops6h 42m

Knoxville McGhee Tyson

Tue 8/29

1 stop4h 32m

$377

Pick Dates

Lambert-St LouisKnoxville McGhee Tyson

STL - TYS

STLTYS

Lambert-St Louis

Sun 7/2

1 stop4h 07m

Knoxville McGhee Tyson

Wed 7/5

2 stops9h 22m

$381

Pick Dates

Lambert-St LouisKnoxville McGhee Tyson

STL - TYS

STLTYS

Lambert-St Louis

Thu 7/20

1 stop5h 17m

Knoxville McGhee Tyson

Sun 7/23

1 stop6h 24m

$419

Pick Dates

Flights are sorted by cheapest first

Deals found on 5/31

Reviews of Airlines Servicing Knoxville

To help decide which airline to fly from St. Louis to Knoxville, see what other customers have to say about American Airlines and Delta. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

2,369 reviews

Check prices

Reviews

1 / 10

Flights were on time with no delays, luggage arrived with the flight. I know the flights were short, but the only drinks offered were water, tea and coffee. It would’ve been nice to have the option to choose a soda, especially since I was in comfort class. The snacks were very small.

Delta

8.0

Very good

2,369 reviews

Delta

8.0

Very good

2,369 reviews

Check prices

Reviews

1 / 10

Flights were on time with no delays, luggage arrived with the flight. I know the flights were short, but the only drinks offered were water, tea and coffee. It would’ve been nice to have the option to choose a soda, especially since I was in comfort class. The snacks were very small.

American Airlines

7.3

Good

2,149 reviews

Delta

8.0

Very good

2,369 reviews

Check prices

Reviews

1 / 10

Flights were on time with no delays, luggage arrived with the flight. I know the flights were short, but the only drinks offered were water, tea and coffee. It would’ve been nice to have the option to choose a soda, especially since I was in comfort class. The snacks were very small.

Related info for your journey

Top 2 airlines flying from St. Louis to Knoxville

Airline	Cheapest	Average	Flexibility	On-time	COVID-19 safety
American Airlines	Cheapest$331	Average$465	FlexibilityNo cancel fee	On-time71%	COVID-19 safety	Search American Airlines flights
Delta	Cheapest$357	Average$466	FlexibilityNo cancel fee	On-timeN/A	COVID-19 safety	Search Delta flights

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Cheap flights from St. Louis to Knoxville (STL - TYS) from $129

This is the cheapest one-way flight price, found on 5/31. Prices may vary by date and flight preferences.

The best prices from Lambert-St Louis to Knoxville McGhee Tyson are usually found in February or April, booked 60 days in advance, depart on a Tuesday or Saturday and return on a Monday

How to find the cheapest flight from St. Louis (STL) to Knoxville (TYS)

All the information you need to plan the best STL to TYS flight in 2023: compare St. Louis to Knoxville flight prices with the expected peak season, weather and rainfall in Knoxville.

Popular in

Cheapest in

Round-trip from

One-way from

What is the cheapest day to fly round-trip from St. Louis to Knoxville?

How far in advance should I book a flight from St. Louis to Knoxville?

What is the cheapest month to fly from St. Louis to Knoxville?

When is the cheapest time to fly from St. Louis to Knoxville (STL - TYS)?

Cheap flights from St. Louis to Knoxville in June, July 2023

The best prices found for STL to TYS flights for June, July

The lowest fares we've come across on flights traveling from St. Louis to Knoxville in June and July 2023. Check back soon for alternative fares.

St. Louis to Knoxville 2023 flight deals

Cheap flights to Knoxville from St. Louis found for this year

The lowest fares we've come across on flights traveling from St. Louis to Knoxville in June and July 2023. Check back soon for alternative fares.

Cheap American Airlines flights from St. Louis to Knoxville

Take a peek at the cheapest American Airlines flights we've detected traveling from St. Louis to Knoxville. Come back soon if you're not finding the exact deal you're looking for.

Cheap Delta flights from St. Louis to Knoxville

Have a look at some of the cheapest available Delta flights departing from St. Louis and landing in Knoxville. Deals are refreshing constantly so come back soon for more options.

Last minute flights from St. Louis to Knoxville

Late deals on return flights to Knoxville from St. Louis, departing today and this week

Check out these flights departing soon from St. Louis to Knoxville. Users should examine the flight details to ensure there are no surprises.

One-way flights to Knoxville from St. Louis

The cheapest one-way flights from St. Louis to Knoxville

Take a look at some of the best available options we've come across on one-way flights from St. Louis to Knoxville. Those seeking round-trip flights from St. Louis to Knoxville should utilize the search form at the the top of the page.

Find flights from St. Louis to Knoxville within your budget

Use the slider to find flights from St. Louis to Knoxville that fit your budget.

Reviews of Airlines Servicing Knoxville

Related info for your journey

Useful info, stats and facts about St. Louis to Knoxville flights.

Which airlines flying from Lambert-St Louis to Knoxville McGhee Tyson have flexible cancellations due to COVID-19?

Can I find flights from St. Louis to Knoxville for under $300 on Cheapflights?

Are there last-minute flights available from St. Louis to Knoxville for under $400?

What are the cheapest airlines flying from St. Louis to Knoxville round-trip?

What does STL to TYS mean?

Other flights from St. Louis

Other flights to Knoxville

Flights to Knoxville from St. Louis

Rent a Car

Top 2 airlines flying from St. Louis to Knoxville

The chart below displays the airlines Cheapflights users traveling from St. Louis to Knoxville choose most often. Cheapest and average prices are based on aggregated data from the past 12 months.

Popular flight searches

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