$126+ Cheap flights from St. Louis to Knoxville (STL - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Oct 6 — Oct 131
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Knoxville
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One-way
Cheapest flights from St. Louis to KnoxvilleExplore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:00 am -
1 stop5h 05m
Wed 10/216:00 am -
1 stop7h 03m
Deal found 9/3![American Airlines logo]()
$243
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/148:30 am -
2 stops10h 40m
Wed 10/211:00 pm -
1 stop8h 00m
Deal found 9/3![Southwest logo]()
$254
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:00 am -
1 stop5h 40m
Mon 10/127:45 pm -
1 stop5h 09m
Deal found 9/1![Delta logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:44 pm -
2 stops15h 45m
Sat 10/3112:00 pm -
1 stop12h 16m
Deal found 9/5![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:29 pm -
2 stops40h 44m
Fri 10/910:07 pm -
1 stop26h 06m
Deal found 9/4![Multiple Airlines logo]()
$263
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:05 am -
1 stop4h 35m
Fri 10/96:23 pm -
1 stop6h 31m
Deal found 9/2![Delta logo]()
$272
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:10 pm -
1 stop4h 33m
Sat 10/104:38 pm -
1 stop5h 35m
Deal found 9/3![American Airlines logo]()
$276
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:50 pm -
1 stop3h 55m
Sun 11/17:25 pm -
1 stop5h 30m
Deal found 9/3![Southwest logo]()
$286
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2910:21 am -
1 stop4h 01m
Sat 10/38:14 pm -
1 stop5h 13m
Deal found 9/5![American Airlines logo]()
$289
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:55 am -
2 stops8h 50m
Tue 12/82:40 pm -
1 stop7h 25m
Deal found 9/6![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:25 pm -
2 stops5h 40m
Sat 10/316:40 am -
2 stops9h 25m
Deal found 9/5![Southwest logo]()
$299
Best flights from St. Louis to KnoxvilleDiscover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
Discover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/148:30 am -
2 stops10h 40m
Wed 10/211:00 pm -
2 stops7h 00m
Deal found 9/3![Southwest logo]()
$259
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:20 pm -
1 stop3h 39m
Fri 10/164:57 pm -
1 stop5h 26m
Deal found 9/2![Delta logo]()
$272
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:00 am -
1 stop5h 53m
Sat 9/128:15 pm -
1 stop5h 12m
Deal found 9/1![American Airlines logo]()
$327
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:55 am -
2 stops8h 50m
Tue 12/87:05 am -
2 stops7h 00m
Deal found 9/6![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:00 am -
1 stop3h 45m
Sun 11/87:45 pm -
1 stop5h 09m
Deal found 9/1![Delta logo]()
$320
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1012:40 pm -
1 stop7h 05m
Fri 11/207:05 am -
2 stops8h 35m
Deal found 9/5![Southwest logo]()
$323
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:31 pm -
1 stop5h 26m
Wed 12/95:40 am -
1 stop6h 49m
Deal found 9/6![Delta logo]()
$327
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:03 am -
1 stop3h 24m
Tue 12/810:41 am -
1 stop3h 47m
Deal found 9/6![Delta logo]()
$327
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:55 am -
1 stop5h 00m
Wed 10/211:00 pm -
2 stops7h 00m
Deal found 9/4![Southwest logo]()
$333
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:40 am -
2 stops8h 50m
Sun 11/87:25 pm -
1 stop5h 30m
Deal found 9/1![Southwest logo]()
$336
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:05 am -
2 stops8h 55m
Sat 9/127:50 am -
2 stops6h 45m
Deal found 9/1![Southwest logo]()
$337
Last-minute flights from St. Louis to KnoxvilleDiscover last-minute flight deals from St. Louis to Knoxville. Data last updated September 6, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Knoxville. Data last updated September 6, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:54 pm -
1 stop6h 12m
Sat 9/128:18 am -
1 stop5h 45m
Deal found 9/1![American Airlines logo]()
$327
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2910:21 am -
1 stop4h 01m
Sat 10/38:14 pm -
1 stop5h 13m
Deal found 9/5![American Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:29 pm -
2 stops40h 44m
Fri 10/910:07 pm -
1 stop26h 06m
Deal found 9/4![Multiple Airlines logo]()
$263
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:10 pm -
1 stop4h 33m
Sat 10/104:38 pm -
1 stop5h 35m
Deal found 9/3![American Airlines logo]()
$276
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:05 am -
1 stop4h 35m
Fri 10/96:23 pm -
1 stop6h 31m
Deal found 9/2![Delta logo]()
$272
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:00 am -
1 stop5h 40m
Mon 10/127:45 pm -
1 stop5h 09m
Deal found 9/1![Delta logo]()
$259
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:00 am -
1 stop5h 05m
Wed 10/216:00 am -
1 stop7h 03m
Deal found 9/3![American Airlines logo]()
$243
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/148:30 am -
2 stops10h 40m
Wed 10/211:00 pm -
1 stop8h 00m
Deal found 9/3![Southwest logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:44 pm -
2 stops15h 45m
Sat 10/3112:00 pm -
1 stop12h 16m
Deal found 9/5![Multiple Airlines logo]()
$261
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:25 pm -
2 stops5h 40m
Sat 10/316:40 am -
2 stops9h 25m
Deal found 9/5![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:50 pm -
1 stop3h 55m
Sun 11/17:25 pm -
1 stop5h 30m
Deal found 9/3![Southwest logo]()
$286
One-way flights from St. Louis to KnoxvilleSearch for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
Search for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:35 pm -
2 stops40h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![Multiple Airlines logo]()
$126
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:25 am -
1 stop7h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Southwest logo]()
$127
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
1 stop3h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Delta logo]()
$130
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:25 am -
1 stop8h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Southwest logo]()
$135
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/610:20 am -
1 stop5h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Southwest logo]()
$145
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1710:05 am -
2 stops8h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Southwest logo]()
$158
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1912:29 pm -
1 stop4h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Delta logo]()
$161
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:45 am -
1 stop6h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Southwest logo]()
$164
Find flight deals from St. Louis to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $243 (American Airlines) |
One-way from | $126 (Kiwi.com) |
Popular in | June |
Cheapest in | August |
Average price | $364 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Wed 10/14
11:25 am-8:10 pm
1 stop7h 45m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$127
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Sat 10/17
7:00 am-1:31 pm
1 stop5h 31m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$130
Quickest round-trip
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Tue 10/6
6:00 am-10:54 am
1 stop3h 54m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$130
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Wed 10/21
1:29 pm-8:49 pm
1 stop6h 20m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$145
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Sat 10/17
10:05 am-7:40 pm
2 stops8h 35m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$158
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Thu 11/19
12:29 pm-6:27 pm
1 stop4h 58m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$161
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Thu 9/10
5:45 am-1:25 pm
1 stop6h 40m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$164
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Sat 11/21
1:40 pm-10:40 pm
2 stops8h 00m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$170
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Tue 10/6
8:10 am-4:40 pm
2 stops7h 30m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$179
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Sat 10/17
7:42 pm-8:08 pm
3 stops47h 26m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$200
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
STL-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Knoxville
What is the cheapest month to book a flight from St. Louis to Knoxville?
Currently, August is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $278). Flying from St. Louis to Knoxville in June is currently the most expensive (average of $566). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Knoxville?
Airfare is below average for this route at the moment.
St. Louis to Knoxville flights typically cost between $256 and $392 in October.The cheapest round-trip price found within the last 5 days was $243 on American Airlines (Oct 14-Oct 21).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 6, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Top 3 airlines flying from St. Louis to Knoxville
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$210 | Average$326 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$217 | Average$378 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$325 | FlexibilityNo cancel fee | On-time63% |