$105+ Cheap flights from St. Louis to Knoxville (STL - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Jun 4 — Jun 111
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Knoxville
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Best
Last-minute
One-way
Cheapest flights from St. Louis to KnoxvilleExplore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:33 pm
STL
- TYS
2 stops21h 07m
Multiple Airlines
Thu 6/43:42 pm
TYS
- STL
1 stop9h 15m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:19 pm
STL
- TYS
1 stop6h 20m
Multiple Airlines
Mon 6/812:49 pm
TYS
- STL
2 stops29h 41m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:19 pm
STL
- TYS
1 stop6h 18m
Multiple Airlines
Fri 6/512:40 pm
TYS
- STL
2 stops21h 15m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$234
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:13 pm
STL
- TYS
1 stop4h 34m
American Airlines
Tue 6/236:12 am
TYS
- STL
1 stop5h 25m
American Airlines
Deal found 5/1![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:35 am
STL
- TYS
2 stops8h 15m
Southwest
Tue 6/95:40 pm
TYS
- STL
1 stop7h 15m
Southwest
Deal found 5/3![Southwest logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/84:19 pm
STL
- TYS
1 stop6h 20m
Multiple Airlines
Fri 6/1212:49 pm
TYS
- STL
2 stops21h 03m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$258
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:15 pm
STL
- TYS
1 stop6h 35m
Southwest
Mon 6/87:45 pm
TYS
- STL
1 stop4h 00m
Southwest
Deal found 5/1![Southwest logo]()
$263
Best flights from St. Louis to KnoxvilleDiscover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
Discover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:05 am
STL
- TYS
1 stop8h 00m
Southwest
Wed 6/106:55 pm
TYS
- STL
1 stop5h 05m
Southwest
Deal found 5/2![Southwest logo]()
$263
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:20 am
STL
- TYS
1 stop6h 00m
Southwest
Sat 6/61:35 pm
TYS
- STL
1 stop4h 50m
Southwest
Deal found 5/2![Southwest logo]()
$277
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:40 am
STL
- TYS
1 stop4h 45m
Southwest
Thu 9/175:45 pm
TYS
- STL
1 stop5h 20m
Southwest
Deal found 5/4![Southwest logo]()
$277
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1212:50 pm
STL
- TYS
2 stops5h 05m
Southwest
Sat 8/151:55 pm
TYS
- STL
1 stop8h 40m
Southwest
Deal found 4/30![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/62:30 pm
STL
- TYS
1 stop5h 50m
Southwest
Thu 6/114:20 pm
TYS
- STL
1 stop8h 35m
Southwest
Deal found 4/30![Southwest logo]()
$288
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2811:40 am
STL
- TYS
1 stop7h 15m
Southwest
Mon 8/312:05 pm
TYS
- STL
1 stop7h 05m
Southwest
Deal found 4/30![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:20 am
STL
- TYS
1 stop2h 45m
Southwest
Sun 10/116:25 am
TYS
- STL
2 stops8h 50m
Southwest
Deal found 5/1![Southwest logo]()
$300
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2910:20 am
STL
- TYS
2 stops9h 00m
Southwest
Sat 8/11:35 pm
TYS
- STL
1 stop4h 50m
Southwest
Deal found 5/4![Southwest logo]()
$304
Last-minute flights from St. Louis to KnoxvilleDiscover last-minute flight deals from St. Louis to Knoxville. Data last updated May 5, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Knoxville. Data last updated May 5, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:33 pm
STL
- TYS
2 stops21h 07m
Multiple Airlines
Thu 6/43:42 pm
TYS
- STL
1 stop9h 15m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:19 pm
STL
- TYS
1 stop6h 18m
Multiple Airlines
Fri 6/512:40 pm
TYS
- STL
2 stops21h 15m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$234
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:35 am
STL
- TYS
2 stops8h 15m
Southwest
Tue 6/95:40 pm
TYS
- STL
1 stop7h 15m
Southwest
Deal found 5/3![Southwest logo]()
$254
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:15 pm
STL
- TYS
1 stop6h 35m
Southwest
Mon 6/87:45 pm
TYS
- STL
1 stop4h 00m
Southwest
Deal found 5/1![Southwest logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:19 pm
STL
- TYS
1 stop6h 20m
Multiple Airlines
Mon 6/812:49 pm
TYS
- STL
2 stops29h 41m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/84:19 pm
STL
- TYS
1 stop6h 20m
Multiple Airlines
Fri 6/1212:49 pm
TYS
- STL
2 stops21h 03m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$258
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:13 pm
STL
- TYS
1 stop4h 34m
American Airlines
Tue 6/236:12 am
TYS
- STL
1 stop5h 25m
American Airlines
Deal found 5/1![American Airlines logo]()
$249
One-way flights from St. Louis to KnoxvilleSearch for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
Search for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:31 pm
STL
- TYS
2 stops26h 19m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:19 pm
STL
- TYS
1 stop6h 18m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$127
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:12 pm
STL
- TYS
1 stop4h 35m
American Airlines
Deal found 4/30![American Airlines logo]()
$150
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:10 pm
STL
- TYS
2 stops6h 05m
Southwest
Deal found 5/2![Southwest logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/207:19 pm
STL
- TYS
3 stops44h 34m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:33 pm
STL
- TYS
2 stops15h 03m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:33 pm
STL
- TYS
1 stop6h 35m
American Airlines
Deal found 5/1![American Airlines logo]()
$314
Find flight deals from St. Louis to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $216 (Kiwi.com) |
One-way from | $105 (Kiwi.com) |
Popular in | January |
Cheapest in | August |
Average price | $322 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Sat 6/6
5:05 am-2:05 pm
1 stop8h 00m
Knoxville McGhee Tyson
Wed 6/10
6:55 pm-11:00 pm
1 stop5h 05m
$263
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Sat 5/30
6:20 am-1:20 pm
1 stop6h 00m
Knoxville McGhee Tyson
Sat 6/6
1:35 pm-5:25 pm
1 stop4h 50m
$277
Quickest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Mon 9/14
7:40 am-1:25 pm
1 stop4h 45m
Knoxville McGhee Tyson
Thu 9/17
5:45 pm-10:05 pm
1 stop5h 20m
$277
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Wed 8/12
12:50 pm-6:55 pm
2 stops5h 05m
Knoxville McGhee Tyson
Sat 8/15
1:55 pm-9:35 pm
1 stop8h 40m
$279
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Sat 6/6
2:30 pm-9:20 pm
1 stop5h 50m
Knoxville McGhee Tyson
Thu 6/11
4:20 pm-11:55 pm
1 stop8h 35m
$288
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Fri 8/28
11:40 am-7:55 pm
1 stop7h 15m
Knoxville McGhee Tyson
Mon 8/31
2:05 pm-8:10 pm
1 stop7h 05m
$299
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Wed 10/7
8:20 am-12:05 pm
1 stop2h 45m
Knoxville McGhee Tyson
Sun 10/11
6:25 am-2:15 pm
2 stops8h 50m
$300
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Wed 7/29
10:20 am-8:20 pm
2 stops9h 00m
Knoxville McGhee Tyson
Sat 8/1
1:35 pm-5:25 pm
1 stop4h 50m
$304
Cheapest one-way
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Fri 5/29
4:19 pm-11:37 pm
1 stop6h 18m
$127
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Sun 6/21
8:25 am-5:10 pm
1 stop7h 45m
$150
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Knoxville in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
STL-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Knoxville
What is the cheapest month to book a flight from St. Louis to Knoxville?
Currently, August is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $277). Flying from St. Louis to Knoxville in January is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Knoxville?
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 5, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Food
7.0
Overall
7.9
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Food
7.0
Overall
7.9
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Food
7.0
Overall
7.9
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Food
7.0
Overall
7.9
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 5, 2026.
St. Louis and Knoxville flights
Browse other St. Louis and Knoxville flight options. Last updated on May 5, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on May 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from St. Louis to Knoxville
Discover the top 3 airlines that operate flights from St. Louis to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$213 | Average$288 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$228 | Average$337 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$326 | FlexibilityNo cancel fee | On-time63% |