$100+ Cheap flights from St. Louis to Knoxville (STL - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
May 24 — May 311
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Knoxville
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Cheapest flights from St. Louis to KnoxvilleExplore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:05 am
STL
- TYS
1 stop5h 05m
Delta
Mon 6/811:55 am
TYS
- STL
1 stop3h 57m
Delta
Deal found 4/23![Delta logo]()
$245
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:15 am
STL
- TYS
1 stop3h 50m
Southwest
Sun 8/301:15 pm
TYS
- STL
1 stop7h 45m
Southwest
Deal found 4/21![Southwest logo]()
$249
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2111:40 am
STL
- TYS
1 stop7h 15m
Southwest
Mon 8/247:10 am
TYS
- STL
1 stop4h 00m
Southwest
Deal found 4/22![Southwest logo]()
$255
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/53:35 pm
STL
- TYS
2 stops5h 55m
Southwest
Mon 6/87:45 pm
TYS
- STL
1 stop5h 20m
Southwest
Deal found 4/22![Southwest logo]()
$261
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:05 pm
STL
- TYS
1 stop3h 42m
Delta
Fri 9/257:20 pm
TYS
- STL
1 stop5h 17m
Delta
Deal found 4/21![Delta logo]()
$265
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:20 am
STL
- TYS
1 stop6h 10m
American Airlines
Sun 5/245:33 pm
TYS
- STL
1 stop7h 26m
American Airlines
Deal found 4/23![American Airlines logo]()
$272
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/252:10 pm
STL
- TYS
1 stop5h 10m
Southwest
Fri 5/296:45 pm
TYS
- STL
1 stop5h 30m
Southwest
Deal found 4/23![Southwest logo]()
$275
Best flights from St. Louis to KnoxvilleDiscover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 24, 2026.
Discover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 24, 2026.
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:15 am
STL
- TYS
1 stop3h 50m
Southwest
Sun 8/301:15 pm
TYS
- STL
1 stop7h 45m
Southwest
Deal found 4/21![Southwest logo]()
$249
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:40 am
STL
- TYS
2 stops9h 55m
Southwest
Mon 8/247:10 am
TYS
- STL
1 stop4h 00m
Southwest
Deal found 4/22![Southwest logo]()
$261
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:35 pm
STL
- TYS
1 stop2h 35m
Southwest
Mon 6/87:45 pm
TYS
- STL
1 stop5h 20m
Southwest
Deal found 4/19![Southwest logo]()
$263
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/252:10 pm
STL
- TYS
1 stop5h 10m
Southwest
Fri 5/296:45 pm
TYS
- STL
1 stop5h 30m
Southwest
Deal found 4/23![Southwest logo]()
$275
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:45 am
STL
- TYS
1 stop6h 40m
Southwest
Fri 8/215:45 pm
TYS
- STL
2 stops6h 20m
Southwest
Deal found 4/22![Southwest logo]()
$292
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:35 pm
STL
- TYS
1 stop2h 35m
Southwest
Mon 7/137:45 pm
TYS
- STL
1 stop5h 20m
Southwest
Deal found 4/21![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:10 pm
STL
- TYS
1 stop5h 10m
Southwest
Sun 5/317:35 pm
TYS
- STL
1 stop5h 10m
Southwest
Deal found 4/21![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:40 am
STL
- TYS
1 stop7h 15m
Southwest
Sun 9/131:15 pm
TYS
- STL
1 stop7h 45m
Southwest
Deal found 4/23![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2511:40 am
STL
- TYS
1 stop7h 15m
Southwest
Sun 9/271:15 pm
TYS
- STL
1 stop7h 45m
Southwest
Deal found 4/23![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/163:10 pm
STL
- TYS
1 stop4h 10m
Southwest
Tue 6/235:40 pm
TYS
- STL
1 stop7h 15m
Southwest
Deal found 4/21![Southwest logo]()
$299
Last-minute flights from St. Louis to KnoxvilleDiscover last-minute flight deals from St. Louis to Knoxville. Data last updated April 24, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Knoxville. Data last updated April 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:55 pm
STL
- TYS
1 stop4h 00m
American Airlines
Wed 6/106:12 am
TYS
- STL
1 stop5h 25m
American Airlines
Deal found 4/22![American Airlines logo]()
$318
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:54 pm
STL
- TYS
1 stop4h 01m
American Airlines
Tue 5/121:20 pm
TYS
- STL
1 stop7h 10m
American Airlines
Deal found 4/21![American Airlines logo]()
$292
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:20 am
STL
- TYS
1 stop6h 10m
American Airlines
Sun 5/245:33 pm
TYS
- STL
1 stop7h 26m
American Airlines
Deal found 4/23![American Airlines logo]()
$272
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:35 am
STL
- TYS
1 stop3h 05m
Southwest
Thu 5/286:45 pm
TYS
- STL
1 stop5h 30m
Southwest
Deal found 4/22![Southwest logo]()
$307
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/221:45 pm
STL
- TYS
2 stops5h 35m
Southwest
Mon 5/256:45 pm
TYS
- STL
1 stop5h 30m
Southwest
Deal found 4/19![Southwest logo]()
$314
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/252:10 pm
STL
- TYS
1 stop5h 10m
Southwest
Fri 5/296:45 pm
TYS
- STL
1 stop5h 30m
Southwest
Deal found 4/23![Southwest logo]()
$275
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:10 pm
STL
- TYS
1 stop5h 10m
Southwest
Sun 5/316:40 am
TYS
- STL
1 stop3h 25m
Southwest
Deal found 4/20![Southwest logo]()
$299
One-way flights from St. Louis to KnoxvilleSearch for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated April 24, 2026.
Search for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated April 24, 2026.
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:00 am
STL
- TYS
1 stop4h 42m
American Airlines
Deal found 4/23![American Airlines logo]()
$100
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:54 pm
STL
- TYS
1 stop4h 01m
American Airlines
Deal found 4/24![American Airlines logo]()
$139
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1810:15 am
STL
- TYS
2 stops9h 05m
Southwest
Deal found 4/24![Southwest logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/43:21 pm
STL
- TYS
2 stops42h 15m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$149
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/268:05 am
STL
- TYS
1 stop3h 00m
Southwest
Deal found 4/22![Southwest logo]()
$150
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2211:15 am
STL
- TYS
2 stops8h 05m
Southwest
Deal found 4/22![Southwest logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/184:19 pm
STL
- TYS
3 stops48h 40m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$177
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/212:10 pm
STL
- TYS
1 stop5h 10m
Southwest
Deal found 4/23![Southwest logo]()
$189
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:12 pm
STL
- TYS
1 stop4h 48m
American Airlines
Deal found 4/19![American Airlines logo]()
$219
Find flight deals from St. Louis to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $245 (Delta) |
One-way from | $100 (American Airlines) |
Popular in | January |
Cheapest in | August |
Average price | $328 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Wed 8/26
7:15 am-12:05 pm
1 stop3h 50m
Knoxville McGhee Tyson
Sun 8/30
1:15 pm-8:00 pm
1 stop7h 45m
$249
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Fri 8/21
7:40 am-6:35 pm
2 stops9h 55m
Knoxville McGhee Tyson
Mon 8/24
7:10 am-10:10 am
1 stop4h 00m
$261
Quickest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Fri 6/5
5:35 pm-9:10 pm
1 stop2h 35m
Knoxville McGhee Tyson
Mon 6/8
7:45 pm-12:05 am
1 stop5h 20m
$263
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Mon 5/25
2:10 pm-8:20 pm
1 stop5h 10m
Knoxville McGhee Tyson
Fri 5/29
6:45 pm-11:15 pm
1 stop5h 30m
$275
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Fri 8/21
5:45 am-1:25 pm
1 stop6h 40m
Knoxville McGhee Tyson
Fri 8/21
5:45 pm-11:05 pm
2 stops6h 20m
$292
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 7/9
5:35 pm-9:10 pm
1 stop2h 35m
Knoxville McGhee Tyson
Mon 7/13
7:45 pm-12:05 am
1 stop5h 20m
$294
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Fri 5/29
2:10 pm-8:20 pm
1 stop5h 10m
Knoxville McGhee Tyson
Sun 5/31
7:35 pm-11:45 pm
1 stop5h 10m
$299
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Fri 9/11
11:40 am-7:55 pm
1 stop7h 15m
Knoxville McGhee Tyson
Sun 9/13
1:15 pm-8:00 pm
1 stop7h 45m
$299
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Fri 9/25
11:40 am-7:55 pm
1 stop7h 15m
Knoxville McGhee Tyson
Sun 9/27
1:15 pm-8:00 pm
1 stop7h 45m
$299
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Tue 6/16
3:10 pm-8:20 pm
1 stop4h 10m
Knoxville McGhee Tyson
Tue 6/23
5:40 pm-11:55 pm
1 stop7h 15m
$299
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Knoxville in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
STL-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Knoxville
What is the cheapest month to book a flight from St. Louis to Knoxville?
Currently, August is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $277). Flying from St. Louis to Knoxville in January is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Knoxville?
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 24, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 24, 2026.
St. Louis and Knoxville flights
Browse other St. Louis and Knoxville flight options. Last updated on April 24, 2026.
Other flights from St. Louis
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Top 3 airlines flying from St. Louis to Knoxville
Discover the top 3 airlines that operate flights from St. Louis to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$213 | Average$288 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$228 | Average$328 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$278 | Average$326 | FlexibilityNo cancel fee | On-time63% |