$109+ Cheap flights from St. Louis to Knoxville (STL - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Nov 22 — Nov 291
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Knoxville
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Best
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One-way
Cheapest flights from St. Louis to KnoxvilleExplore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2026.
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2026.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:13 am -
1 stop3h 15m
Tue 11/246:10 pm -
1 stop4h 32m
Deal found 10/21![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:55 am -
2 stops8h 55m
Sat 11/148:15 am -
1 stop7h 05m
Deal found 10/22![Southwest logo]()
$222
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/99:40 am -
1 stop6h 19m
Fri 11/136:45 am -
1 stop6h 25m
Deal found 10/22![United Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:20 pm -
1 stop14h 51m
Mon 12/216:33 pm -
2 stops41h 20m
Deal found 10/21![Multiple Airlines logo]()
$283
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:18 pm -
1 stop3h 41m
Mon 11/236:10 pm -
1 stop6h 46m
Deal found 10/19![Delta logo]()
$293
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/237:15 pm -
1 stop3h 35m
Tue 12/2910:11 am -
1 stop5h 32m
Deal found 10/21![Delta logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:34 pm -
2 stops16h 04m
Sun 11/157:00 am -
1 stop17h 16m
Deal found 10/22![Multiple Airlines logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:34 pm -
2 stops21h 44m
Fri 11/138:25 am -
1 stop15h 51m
Deal found 10/22![Multiple Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:35 am -
1 stop3h 45m
Sun 11/227:25 pm -
1 stop5h 30m
Deal found 10/21![Southwest logo]()
$328
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1110:25 am -
1 stop5h 14m
Sun 1/102:49 pm -
1 stop6h 12m
Deal found 10/18![American Airlines logo]()
$329
Best flights from St. Louis to KnoxvilleDiscover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 23, 2026.
Discover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 23, 2026.
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:18 pm -
1 stop3h 41m
Mon 11/236:10 pm -
1 stop6h 46m
Deal found 10/19![Delta logo]()
$293
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/305:02 am -
1 stop7h 18m
Wed 2/310:45 am -
1 stop6h 33m
Deal found 10/20![United Airlines logo]()
$307
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:10 am -
2 stops8h 50m
Sun 1/102:40 pm -
1 stop6h 05m
Deal found 10/18![Southwest logo]()
$334
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:30 am -
1 stop4h 25m
Tue 11/247:39 am -
1 stop6h 05m
Deal found 10/18![American Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:30 am -
1 stop4h 43m
Tue 11/246:45 am -
1 stop6h 25m
Deal found 10/18![United Airlines logo]()
$348
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:30 am -
2 stops10h 15m
Tue 11/175:15 pm -
1 stop5h 45m
Deal found 10/20![Southwest logo]()
$357
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/126:00 am -
1 stop4h 06m
Mon 2/157:20 pm -
1 stop5h 19m
Deal found 10/21![Delta logo]()
$363
Last-minute flights from St. Louis to KnoxvilleDiscover last-minute flight deals from St. Louis to Knoxville. Data last updated October 23, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Knoxville. Data last updated October 23, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:00 am -
1 stop6h 12m
Tue 11/175:32 pm -
1 stop5h 27m
Deal found 10/20![American Airlines logo]()
$352
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/99:40 am -
1 stop6h 19m
Fri 11/136:45 am -
1 stop6h 25m
Deal found 10/22![United Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:34 pm -
2 stops21h 44m
Fri 11/138:25 am -
1 stop15h 51m
Deal found 10/22![Multiple Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:55 am -
2 stops8h 55m
Sat 11/148:15 am -
1 stop7h 05m
Deal found 10/22![Southwest logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:34 pm -
2 stops16h 04m
Sun 11/157:00 am -
1 stop17h 16m
Deal found 10/22![Multiple Airlines logo]()
$302
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:18 pm -
1 stop3h 41m
Mon 11/236:10 pm -
1 stop6h 46m
Deal found 10/19![Delta logo]()
$293
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1610:15 am -
1 stop5h 25m
Mon 11/2312:50 pm -
2 stops9h 30m
Deal found 10/19![Southwest logo]()
$351
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:13 am -
1 stop3h 15m
Tue 11/246:10 pm -
1 stop4h 32m
Deal found 10/21![Delta logo]()
$217
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:30 am -
1 stop4h 43m
Tue 11/246:45 am -
1 stop6h 25m
Deal found 10/18![United Airlines logo]()
$348
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:35 am -
1 stop3h 45m
Sun 11/227:25 pm -
1 stop5h 30m
Deal found 10/21![Southwest logo]()
$328
One-way flights from St. Louis to KnoxvilleSearch for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 23, 2026.
Search for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 23, 2026.
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:18 pm -
1 stop3h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Delta logo]()
$109
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:55 am -
2 stops8h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Southwest logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:34 pm -
2 stops21h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$124
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am -
1 stop4h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Delta logo]()
$193
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/122:40 pm -
2 stops4h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Southwest logo]()
$234
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/411:35 am -
1 stop6h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![American Airlines logo]()
$244
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:55 am -
2 stops8h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Southwest logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:00 pm -
3 stops51h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:18 pm -
3 stops43h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$271
Find flight deals from St. Louis to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $217 (Delta) |
One-way from | $109 (Delta) |
Popular in | June |
Cheapest in | August |
Average price | $398 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 23, 2026.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Wed 11/11
10:55 am-8:50 pm
2 stops8h 55m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$114
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Mon 11/9
6:34 pm-5:18 pm
2 stops21h 44m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$124
Quickest round-trip
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Thu 11/12
6:00 am-11:28 am
1 stop4h 28m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$193
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Thu 11/12
2:40 pm-8:35 pm
2 stops4h 55m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$234
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Thu 11/5
10:34 am-5:40 pm
1 stop6h 06m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$244
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Wed 11/4
10:55 am-8:50 pm
2 stops8h 55m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$249
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Thu 11/5
2:00 pm-6:35 pm
3 stops51h 35m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$250
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Wed 11/4
11:35 am-6:46 pm
1 stop6h 11m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$281
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Mon 11/16
7:18 pm-11:59 pm
1 stop3h 41m
Knoxville McGhee Tyson
Mon 11/23
6:10 pm-11:56 pm
1 stop6h 46m
$293
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Sat 1/30
5:02 am-1:20 pm
1 stop7h 18m
Knoxville McGhee Tyson
Wed 2/3
10:45 am-4:18 pm
1 stop6h 33m
$307
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Knoxville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
STL-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Knoxville
What is the cheapest month to book a flight from St. Louis to Knoxville?
Currently, August is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $278). Flying from St. Louis to Knoxville in June is currently the most expensive (average of $566). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Knoxville?
Airfare is below average for this route at the moment.
St. Louis to Knoxville flights typically cost between $276 and $434 in November.The cheapest round-trip price found within the last 5 days was $217 on Delta (Nov 17-Nov 24).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 23, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Food
7.0
Comfort
8.0
Entertainment
7.4
Overall
7.9
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Boarding
8.1
Crew
8.6
Food
7.0
Comfort
8.0
Entertainment
7.4
Overall
7.9
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Boarding
8.1
Crew
8.6
Food
7.0
Comfort
8.0
Entertainment
7.4
Overall
7.9
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Boarding
8.1
Crew
8.6
Food
7.0
Comfort
8.0
Entertainment
7.4
Overall
7.9
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Newport
Bryson City
Murphy
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Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on October 23, 2026.
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Top 3 airlines flying from St. Louis to Knoxville
Discover the top 3 airlines that operate flights from St. Louis to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$210 | Average$326 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$210 | Average$388 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$326 | FlexibilityNo cancel fee | On-time63% |