$102+ Cheap flights from St. Louis to Knoxville (STL - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/13. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Aug 23 — Aug 301
Round-trip
1 adult, Economy
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Cheapest flights from St. Louis to KnoxvilleExplore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 24, 2026.
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 24, 2026.
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:36 am
STL
- TYS
1 stop5h 22m
American Airlines
Sat 9/128:15 pm
TYS
- STL
1 stop5h 12m
American Airlines
Deal found 7/22![American Airlines logo]()
$210
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/39:15 am
STL
- TYS
1 stop6h 55m
Southwest
Thu 9/102:05 pm
TYS
- STL
1 stop4h 50m
Southwest
Deal found 7/22![Southwest logo]()
$211
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/39:15 am
STL
- TYS
1 stop6h 55m
Southwest
Tue 9/88:05 am
TYS
- STL
2 stops8h 05m
Southwest
Deal found 7/22![Southwest logo]()
$216
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:45 am
STL
- TYS
2 stops8h 05m
Southwest
Wed 8/268:05 am
TYS
- STL
2 stops9h 40m
Southwest
Deal found 7/22![Southwest logo]()
$221
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/138:30 am
STL
- TYS
2 stops10h 35m
Southwest
Sat 10/176:40 am
TYS
- STL
1 stop3h 35m
Southwest
Deal found 7/23![Southwest logo]()
$222
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
STL
- TYS
1 stop5h 51m
American Airlines
Mon 8/247:25 pm
TYS
- STL
1 stop4h 15m
American Airlines
Deal found 7/19![American Airlines logo]()
$224
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:05 am
STL
- TYS
1 stop6h 15m
Southwest
Mon 8/2412:40 pm
TYS
- STL
2 stops7h 30m
Southwest
Deal found 7/19![Southwest logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1810:35 am
STL
- TYS
2 stops11h 55m
Multiple Airlines
Thu 10/226:30 am
TYS
- STL
1 stop13h 45m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$235
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:10 am
STL
- TYS
1 stop5h 30m
Delta
Sat 10/176:00 am
TYS
- STL
1 stop5h 51m
Delta
Deal found 7/22![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:15 am
STL
- TYS
2 stops7h 40m
Southwest
Tue 8/257:00 am
TYS
- STL
2 stops8h 50m
Southwest
Deal found 7/19![Southwest logo]()
$238
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:00 am
STL
- TYS
1 stop3h 20m
Southwest
Mon 8/2412:40 pm
TYS
- STL
2 stops7h 30m
Southwest
Deal found 7/20![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/54:30 pm
STL
- TYS
1 stop3h 00m
Southwest
Mon 11/97:25 pm
TYS
- STL
1 stop5h 30m
Southwest
Deal found 7/23![Southwest logo]()
$246
Best flights from St. Louis to KnoxvilleDiscover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 24, 2026.
Discover carefully curated flight deals from St. Louis to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 24, 2026.
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/39:15 am
STL
- TYS
1 stop6h 55m
Southwest
Thu 9/107:10 am
TYS
- STL
1 stop4h 00m
Southwest
Deal found 7/21![Southwest logo]()
$211
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:00 am
STL
- TYS
1 stop5h 58m
Delta
Tue 9/227:50 am
TYS
- STL
1 stop6h 33m
Delta
Deal found 7/19![Delta logo]()
$237
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:25 am
STL
- TYS
1 stop4h 53m
United Airlines
Wed 8/126:02 pm
TYS
- STL
1 stop5h 57m
United Airlines
Deal found 7/19![United Airlines logo]()
$237
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1312:00 pm
STL
- TYS
1 stop4h 36m
Delta
Sat 10/176:00 am
TYS
- STL
1 stop4h 37m
Delta
Deal found 7/19![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/54:30 pm
STL
- TYS
1 stop3h 00m
Southwest
Mon 11/97:25 pm
TYS
- STL
1 stop5h 30m
Southwest
Deal found 7/23![Southwest logo]()
$246
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:59 pm
STL
- TYS
1 stop3h 47m
Delta
Sat 11/212:30 pm
TYS
- STL
1 stop4h 31m
Delta
Deal found 7/23![Delta logo]()
$260
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/82:30 pm
STL
- TYS
1 stop7h 10m
Southwest
Sat 10/106:40 am
TYS
- STL
1 stop3h 35m
Southwest
Deal found 7/20![Southwest logo]()
$260
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:10 am
STL
- TYS
1 stop6h 00m
Southwest
Mon 9/281:00 pm
TYS
- STL
1 stop8h 00m
Southwest
Deal found 7/23![Southwest logo]()
$270
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:40 am
STL
- TYS
1 stop8h 20m
Southwest
Fri 11/137:05 am
TYS
- STL
2 stops8h 35m
Southwest
Deal found 7/22![Southwest logo]()
$271
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:10 am
STL
- TYS
2 stops7h 25m
Southwest
Mon 8/2412:40 pm
TYS
- STL
2 stops7h 30m
Southwest
Deal found 7/20![Southwest logo]()
$278
Last-minute flights from St. Louis to KnoxvilleDiscover last-minute flight deals from St. Louis to Knoxville. Data last updated July 24, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Knoxville. Data last updated July 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:25 pm
STL
- TYS
1 stop4h 34m
American Airlines
Mon 8/245:15 am
TYS
- STL
1 stop5h 17m
American Airlines
Deal found 7/20![American Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:00 am
STL
- TYS
1 stop3h 20m
Southwest
Mon 8/2412:40 pm
TYS
- STL
2 stops7h 30m
Southwest
Deal found 7/20![Southwest logo]()
$242
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1812:59 pm
STL
- TYS
1 stop6h 54m
United Airlines
Tue 8/256:02 pm
TYS
- STL
1 stop4h 58m
United Airlines
Deal found 7/19![United Airlines logo]()
$211
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/181:40 pm
STL
- TYS
1 stop5h 10m
Southwest
Tue 8/257:00 am
TYS
- STL
2 stops8h 50m
Southwest
Deal found 7/19![Southwest logo]()
$216
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
STL
- TYS
1 stop5h 51m
American Airlines
Mon 8/247:25 pm
TYS
- STL
1 stop4h 15m
American Airlines
Deal found 7/19![American Airlines logo]()
$224
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:05 am
STL
- TYS
1 stop6h 15m
Southwest
Mon 8/2412:40 pm
TYS
- STL
2 stops7h 30m
Southwest
Deal found 7/19![Southwest logo]()
$229
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:45 am
STL
- TYS
2 stops8h 05m
Southwest
Wed 8/268:05 am
TYS
- STL
2 stops9h 40m
Southwest
Deal found 7/22![Southwest logo]()
$221
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:45 am
STL
- TYS
1 stop6h 40m
Southwest
Fri 8/215:45 pm
TYS
- STL
1 stop5h 20m
Southwest
Deal found 7/20![Southwest logo]()
$255
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/289:15 am
STL
- TYS
2 stops8h 20m
Southwest
Mon 8/311:00 pm
TYS
- STL
1 stop8h 00m
Southwest
Deal found 7/22![Southwest logo]()
$265
One-way flights from St. Louis to KnoxvilleSearch for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated July 24, 2026.
Search for one-way flight options from St. Louis to Knoxville. Find affordable one-way fares based on user searches. Data last updated July 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:34 pm
STL
- TYS
2 stops26h 50m
Multiple Airlines
Deal found 7/21![Multiple Airlines logo]()
$102
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:36 am
STL
- TYS
1 stop5h 20m
American Airlines
Deal found 7/21![American Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/306:17 pm
STL
- TYS
2 stops22h 48m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$109
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:50 am
STL
- TYS
2 stops9h 50m
Southwest
Deal found 7/23![Southwest logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/144:57 pm
STL
- TYS
2 stops28h 06m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2510:35 am
STL
- TYS
2 stops31h 17m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$116
This Trip.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:08 pm
STL
- TYS
1 stop22h 16m
Frontier
Deal found 7/22![Frontier logo]()
$149
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/306:40 am
STL
- TYS
1 stop4h 45m
Southwest
Deal found 7/23![Southwest logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:35 am
STL
- TYS
3 stops26h 23m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$167
Find flight deals from St. Louis to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $210 (American Airlines) |
One-way from | $102 (Kiwi.com) |
Popular in | June |
Cheapest in | August |
Average price | $312 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 24, 2026.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 9/3
9:15 am-5:10 pm
1 stop6h 55m
Knoxville McGhee Tyson
Thu 9/10
7:10 am-10:10 am
1 stop4h 00m
$211
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Sat 9/19
6:00 am-12:58 pm
1 stop5h 58m
Knoxville McGhee Tyson
Tue 9/22
7:50 am-1:23 pm
1 stop6h 33m
$237
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Wed 8/12
7:25 am-1:18 pm
1 stop4h 53m
Knoxville McGhee Tyson
Wed 8/12
6:02 pm-10:59 pm
1 stop5h 57m
$237
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Tue 10/13
12:00 pm-5:36 pm
1 stop4h 36m
Knoxville McGhee Tyson
Sat 10/17
6:00 am-9:37 am
1 stop4h 37m
$237
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 11/5
4:30 pm-8:30 pm
1 stop3h 00m
Knoxville McGhee Tyson
Mon 11/9
7:25 pm-11:55 pm
1 stop5h 30m
$246
Quickest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Tue 11/17
6:59 pm-11:46 pm
1 stop3h 47m
Knoxville McGhee Tyson
Sat 11/21
2:30 pm-6:01 pm
1 stop4h 31m
$260
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 10/8
2:30 pm-10:40 pm
1 stop7h 10m
Knoxville McGhee Tyson
Sat 10/10
6:40 am-9:15 am
1 stop3h 35m
$260
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Fri 9/25
10:10 am-5:10 pm
1 stop6h 00m
Knoxville McGhee Tyson
Mon 9/28
1:00 pm-8:00 pm
1 stop8h 00m
$270
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Mon 11/9
5:40 am-3:00 pm
1 stop8h 20m
Knoxville McGhee Tyson
Fri 11/13
7:05 am-2:40 pm
2 stops8h 35m
$271
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Mon 8/17
10:10 am-6:35 pm
2 stops7h 25m
Knoxville McGhee Tyson
Mon 8/24
12:40 pm-7:10 pm
2 stops7h 30m
$278
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Knoxville in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
STL-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Knoxville
What is the cheapest month to book a flight from St. Louis to Knoxville?
Currently, August is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $298). Flying from St. Louis to Knoxville in June is currently the most expensive (average of $566). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Knoxville?
Airfare is below average for this route at the moment.
St. Louis to Knoxville flights typically cost between $280 and $358 in September.The cheapest round-trip price found within the last 5 days was $210 on American Airlines (Sep 5-Sep 12).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 24, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from St. Louis to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 24, 2026.
St. Louis and Knoxville flights
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Top 3 airlines flying from St. Louis to Knoxville
Discover the top 3 airlines that operate flights from St. Louis to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$378 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$235 | Average$333 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$278 | Average$326 | FlexibilityNo cancel fee | On-time63% |