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$144+ Cheap flights from Columbia, MO to Knoxville (COU - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/15. Fares are subject to change and may not be available on all flights or dates of travel.
COU — TYS
May 25 — Jun 11
Mon 5/25
Mon 6/1
1 adult, Economy
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Cheap flight deals from Columbia to Knoxville

Cheapest flights from Columbia to Knoxville
Explore the most affordable flight options available from Columbia to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 25, 2026.

This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:25 am
COU
-
TYS
1 stop6h 52m
American Airlines
Wed 5/136:00 am
TYS
-
COU
1 stop6h 35m
American Airlines
Deal found 4/24$308
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:30 am
COU
-
TYS
1 stop4h 38m
United Airlines
Sun 5/107:00 am
TYS
-
COU
1 stop4h 57m
United Airlines
Deal found 4/21$331
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:00 am
COU
-
TYS
2 stops7h 24m
American Airlines
Sun 5/106:00 am
TYS
-
COU
1 stop6h 35m
American Airlines
Deal found 4/21$344
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:30 am
COU
-
TYS
1 stop4h 24m
United Airlines
Mon 5/117:00 am
TYS
-
COU
1 stop4h 55m
United Airlines
Deal found 4/22$383
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:16 pm
COU
-
TYS
2 stops7h 39m
United Airlines
Wed 10/289:15 am
TYS
-
COU
2 stops12h 15m
United Airlines
Deal found 4/20$424
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:30 am
COU
-
TYS
1 stop4h 24m
United Airlines
Mon 5/47:00 am
TYS
-
COU
1 stop4h 55m
United Airlines
Deal found 4/21$438
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:25 am
COU
-
TYS
1 stop6h 54m
American Airlines
Mon 5/46:54 pm
TYS
-
COU
1 stop4h 59m
American Airlines
Deal found 4/23$449
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:05 pm
COU
-
TYS
1 stop4h 40m
American Airlines
Sat 12/2611:20 am
TYS
-
COU
1 stop4h 29m
American Airlines
Deal found 4/21$454

Find flight deals from Columbia to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$308
(American Airlines)

One-way from

$144
(Kiwi.com)
Provider with most accurate pricing for Columbia Regional-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Columbia Regional-Knoxville McGhee Tyson flights.
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From Columbia Regional to Knoxville McGhee Tyson
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One-way flight from Columbia Regional to Knoxville McGhee Tyson
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 25, 2026.
Use the filters below to find and compare flights from Columbia to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 5/9

7:25 am-3:17 pm

1 stop6h 52m

Knoxville McGhee Tyson

Wed 5/13

6:00 am-11:35 am

1 stop6h 35m

$308

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 5/6

11:30 am-5:08 pm

1 stop4h 38m

Knoxville McGhee Tyson

Sun 5/10

7:00 am-10:57 am

1 stop4h 57m

$331

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 5/6

6:00 am-2:24 pm

2 stops7h 24m

Knoxville McGhee Tyson

Sun 5/10

6:00 am-11:35 am

1 stop6h 35m

$344
Quickest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 5/7

11:30 am-4:54 pm

1 stop4h 24m

Knoxville McGhee Tyson

Mon 5/11

7:00 am-10:55 am

1 stop4h 55m

$383

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 5/18

5:21 pm-11:56 pm

1 stop5h 35m

Knoxville McGhee Tyson

Wed 5/20

1:20 pm-7:13 pm

1 stop6h 53m

$526

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 5/7

10:16 am-4:39 pm

1 stop5h 23m

Knoxville McGhee Tyson

Mon 5/11

2:06 pm-9:29 pm

2 stops8h 23m

$617
Cheapest one-way
Quickest one-way

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/15

11:29 am-3:06 pm

1 stop26h 37m

$144

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/20

Sorted by cheapest first

Compare providers for flights from Columbia to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Columbia, Missouri-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Columbia, Missouri-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Columbia to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Columbia to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Columbia, Missouri to Knoxville?

    For as low as $331, American Airlines can have you in Knoxville from Columbia, Missouri in 4h 38m. Columbia, Missouri and Knoxville are separated by a distance of 497 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Columbia to Knoxville that include hotel bookings?

    Yes. In addition to deals on Columbia to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Knoxville.

  • Can I find deals for business class flights from Columbia to Knoxville?

    Yes. Cheapflights offers flight deals from Columbia to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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