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Knoxville

$176+ Cheap flights from Columbia, MO to Knoxville (COU - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/15. Fares are subject to change and may not be available on all flights or dates of travel.
COU — TYS
Aug 6 — Aug 131
Thu 8/6
Thu 8/13
1 adult, Economy
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Cheap flight deals from Columbia to Knoxville

Cheapest flights from Columbia to Knoxville
Explore the most affordable flight options available from Columbia to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 7, 2026.

This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:59 pm
COU
-
TYS
1 stop7h 42m
Allegiant Air
Sun 11/82:09 pm
TYS
-
COU
1 stop27h 09m
Allegiant Air
Deal found 7/6$276
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/612:43 pm
COU
-
TYS
1 stop4h 39m
American Airlines
Wed 8/126:03 am
TYS
-
COU
1 stop6h 13m
American Airlines
Deal found 7/2$278
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2611:33 am
COU
-
TYS
1 stop9h 11m
Allegiant Air
Sun 11/82:09 pm
TYS
-
COU
1 stop27h 09m
Allegiant Air
Deal found 7/6$282
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/311:45 am
COU
-
TYS
1 stop6h 45m
American Airlines
Sun 8/96:03 am
TYS
-
COU
1 stop6h 13m
American Airlines
Deal found 7/3$313
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2611:33 am
COU
-
TYS
1 stop9h 11m
Allegiant Air
Thu 11/122:09 pm
TYS
-
COU
1 stop27h 01m
Allegiant Air
Deal found 7/6$320
This United Airlines deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2910:55 am
COU
-
TYS
1 stop5h 03m
United Airlines
Wed 9/27:00 am
TYS
-
COU
1 stop4h 16m
United Airlines
Deal found 7/6$348
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/161:04 pm
COU
-
TYS
1 stop9h 01m
Allegiant Air
Sun 10/184:59 pm
TYS
-
COU
1 stop27h 20m
Allegiant Air
Deal found 7/5$357
This United Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:25 pm
COU
-
TYS
1 stop4h 14m
United Airlines
Sat 7/115:50 pm
TYS
-
COU
1 stop6h 43m
United Airlines
Deal found 7/2$358
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:45 am
COU
-
TYS
1 stop6h 43m
American Airlines
Fri 7/101:00 pm
TYS
-
COU
1 stop6h 01m
American Airlines
Deal found 7/2$363
This United Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/38:00 am
COU
-
TYS
2 stops11h 34m
United Airlines
Fri 7/106:00 am
TYS
-
COU
1 stop5h 13m
United Airlines
Deal found 7/2$364

Find flight deals from Columbia to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$276
(Kiwi.com)

One-way from

$176
(Kiwi.com)
Provider with most accurate pricing for Columbia Regional-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-Knoxville McGhee Tyson flights.
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From Columbia Regional to Knoxville McGhee Tyson
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One-way flight from Columbia Regional to Knoxville McGhee Tyson
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 7, 2026.
Use the filters below to find and compare flights from Columbia to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 8/6

12:43 pm-6:22 pm

1 stop4h 39m

Knoxville McGhee Tyson

Wed 8/12

6:03 am-11:16 am

1 stop6h 13m

$278

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 8/3

11:45 am-7:30 pm

1 stop6h 45m

Knoxville McGhee Tyson

Sun 8/9

6:03 am-11:16 am

1 stop6h 13m

$313
Quickest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 8/29

10:55 am-4:58 pm

1 stop5h 03m

Knoxville McGhee Tyson

Wed 9/2

7:00 am-10:16 am

1 stop4h 16m

$348

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 10/16

1:04 pm-11:05 pm

1 stop9h 01m

Knoxville McGhee Tyson

Sun 10/18

4:59 pm-7:19 pm

1 stop27h 20m

$357
Cheapest one-way

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 7/15

11:44 am-12:46 pm

2 stops48h 02m

$202
Quickest one-way

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 11/19

5:58 pm-11:52 pm

1 stop4h 54m

$253

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sun 7/12

6:20 am-12:30 pm

1 stop5h 10m

$363

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 7/14

7:20 am-3:42 pm

1 stop7h 22m

$363

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 7/13

10:49 am-11:54 pm

2 stops12h 05m

$369

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 7/13

11:45 am-11:59 pm

2 stops11h 14m

$369

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

Compare providers for flights from Columbia to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to Knoxville in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Columbia, Missouri-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Columbia, Missouri-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Columbia to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 7, 2026.
See what other customers who have flown with American Airlines from Columbia to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,784 reviews

Food

6.4

Crew

7.9

Entertainment

6.8

Boarding

7.5

Comfort

7.2

Overall

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!
American Airlines
7.1
Good
11,784 reviews
American Airlines
7.1
Good
11,784 reviews

Food

6.4

Crew

7.9

Entertainment

6.8

Boarding

7.5

Comfort

7.2

Overall

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!

Related info for your journey

Find useful and relevant information for your journey from Columbia to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Columbia, Missouri to Knoxville?

    For as low as $278, American Airlines can have you in Knoxville from Columbia, Missouri in 4h 39m. Columbia, Missouri and Knoxville are separated by a distance of 497 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Columbia, Missouri to Knoxville round-trip?

    Our cheapest airline available from Columbia, Missouri to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $383 on this airline.

  • Can I find deals for flights from Columbia to Knoxville that include hotel bookings?

    Yes. In addition to deals on Columbia to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Knoxville.

  • Can I find deals for business class flights from Columbia to Knoxville?

    Yes. Cheapflights offers flight deals from Columbia to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Columbia to Knoxville

Discover the top airline that operate flights from Columbia to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$383Average$529FlexibilityNo cancel feeOn-time71%

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