$288+ Cheap flights from Columbia, MO to Knoxville (COU - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
COU — TYS
Oct 4 — Oct 111
Round-trip
1 adult, Economy
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Find cheap flights from Columbia to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to Knoxville
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Best
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Cheapest flights from Columbia to KnoxvilleExplore the most affordable flight options available from Columbia to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
Explore the most affordable flight options available from Columbia to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 4, 2026.
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:24 pm -
1 stop4h 35m
Sat 10/244:38 pm -
1 stop5h 17m
Deal found 9/2![American Airlines logo]()
$288
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:59 pm -
1 stop7h 42m
Sun 10/254:42 pm -
1 stop22h 20m
Deal found 9/2![Allegiant Air logo]()
$310
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:20 am -
1 stop4h 38m
Sat 9/196:00 am -
1 stop5h 38m
Deal found 8/31![United Airlines logo]()
$318
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:25 pm -
1 stop4h 34m
Sun 11/15:30 am -
1 stop7h 05m
Deal found 9/3![American Airlines logo]()
$323
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:28 pm -
1 stop4h 22m
Wed 11/255:30 pm -
1 stop5h 13m
Deal found 9/2![American Airlines logo]()
$351
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:20 am -
1 stop4h 38m
Sun 9/206:00 am -
1 stop5h 39m
Deal found 9/2![United Airlines logo]()
$360
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:17 pm -
1 stop5h 01m
Sun 9/136:00 am -
1 stop6h 29m
Deal found 8/31![American Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:12 pm -
2 stops7h 47m
Sun 9/136:00 am -
1 stop5h 39m
Deal found 8/31![United Airlines logo]()
$374
Best flights from Columbia to KnoxvilleDiscover carefully curated flight deals from Columbia to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
Discover carefully curated flight deals from Columbia to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 4, 2026.
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:20 am -
1 stop4h 38m
Sat 9/196:00 am -
1 stop5h 38m
Deal found 8/31![United Airlines logo]()
$318
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/303:00 pm -
1 stop4h 59m
Wed 2/36:40 am -
1 stop5h 15m
Deal found 8/31![United Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:15 am -
2 stops7h 22m
Sun 9/206:00 am -
1 stop5h 39m
Deal found 9/2![United Airlines logo]()
$365
Last-minute flights from Columbia to KnoxvilleDiscover last-minute flight deals from Columbia to Knoxville. Data last updated September 4, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to Knoxville. Data last updated September 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:17 pm -
1 stop5h 01m
Sun 9/136:00 am -
1 stop6h 29m
Deal found 8/31![American Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:12 pm -
2 stops7h 47m
Sun 9/136:00 am -
1 stop5h 39m
Deal found 8/31![United Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:20 am -
1 stop4h 38m
Sat 9/196:00 am -
1 stop5h 38m
Deal found 8/31![United Airlines logo]()
$318
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:20 am -
1 stop4h 38m
Sun 9/206:00 am -
1 stop5h 39m
Deal found 9/2![United Airlines logo]()
$360
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:17 am -
1 stop4h 41m
Sun 10/46:00 am -
1 stop5h 39m
Deal found 8/30![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:24 pm -
1 stop4h 35m
Sat 10/244:38 pm -
1 stop5h 17m
Deal found 9/2![American Airlines logo]()
$288
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:59 pm -
1 stop7h 42m
Sun 10/254:42 pm -
1 stop22h 20m
Deal found 9/2![Allegiant Air logo]()
$310
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:25 pm -
1 stop4h 34m
Sun 11/15:30 am -
1 stop7h 05m
Deal found 9/3![American Airlines logo]()
$323
One-way flights from Columbia to KnoxvilleSearch for one-way flight options from Columbia to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 4, 2026.
Search for one-way flight options from Columbia to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 4, 2026.
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:28 pm -
1 stop4h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![American Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/285:25 pm -
3 stops52h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Allegiant Air logo]()
$399
Find flight deals from Columbia to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $288 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
Use the filters below to find and compare flights from Columbia to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaKnoxville
COU Columbia Regional - TYS Knoxville McGhee Tyson
COUTYS
Columbia Regional
Tue 9/15
11:20 am-4:58 pm
1 stop4h 38m
Knoxville McGhee Tyson
Sat 9/19
6:00 am-10:38 am
1 stop5h 38m
$318
Quickest round-trip
ColumbiaKnoxville
COU Columbia Regional - TYS Knoxville McGhee Tyson
COUTYS
Columbia Regional
Sat 11/28
6:28 pm-11:50 pm
1 stop4h 22m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$343
ColumbiaKnoxville
COU Columbia Regional - TYS Knoxville McGhee Tyson
COUTYS
Columbia Regional
Sat 1/30
3:00 pm-8:59 pm
1 stop4h 59m
Knoxville McGhee Tyson
Wed 2/3
6:40 am-10:55 am
1 stop5h 15m
$358
ColumbiaKnoxville
COU Columbia Regional - TYS Knoxville McGhee Tyson
COUTYS
Columbia Regional
Wed 9/16
6:15 am-2:37 pm
2 stops7h 22m
Knoxville McGhee Tyson
Sun 9/20
6:00 am-10:39 am
1 stop5h 39m
$365
Sorted by cheapest first
Compare providers for flights from Columbia to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Columbia, Missouri-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Columbia, Missouri-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Columbia to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbia with our price prediction graph.
COU-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 4, 2026.
See what other customers who have flown with American Airlines from Columbia to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.4
Boarding
7.5
Comfort
7.2
Crew
7.9
Overall
7.1
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Food
6.4
Boarding
7.5
Comfort
7.2
Crew
7.9
Overall
7.1
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Columbia to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Top airline flying from Columbia to Knoxville
Discover the top airline that operate flights from Columbia to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$288 | Average$497 | FlexibilityNo cancel fee | On-time71% |