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$245+ Cheap flights from Columbia, MO to Knoxville (COU - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
COU — TYS
Jul 11 — Jul 181
Sat 7/11
Sat 7/18
1 adult, Economy
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Cheap flight deals from Columbia to Knoxville

Cheapest flights from Columbia to Knoxville
Explore the most affordable flight options available from Columbia to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 11, 2026.

This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:04 pm
COU
-
TYS
1 stop8h 54m
Allegiant Air
Thu 10/87:36 pm
TYS
-
COU
1 stop19h 45m
Allegiant Air
Deal found 6/9$245
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:47 pm
COU
-
TYS
1 stop6h 33m
Allegiant Air
Thu 10/87:36 pm
TYS
-
COU
1 stop19h 45m
Allegiant Air
Deal found 6/9$259
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/811:44 am
COU
-
TYS
1 stop5h 41m
Allegiant Air
Tue 7/144:20 pm
TYS
-
COU
1 stop19h 34m
Allegiant Air
Deal found 6/10$275
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/113:25 pm
COU
-
TYS
1 stop4h 19m
United Airlines
Sat 7/256:00 am
TYS
-
COU
1 stop5h 13m
United Airlines
Deal found 6/10$278
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:22 pm
COU
-
TYS
1 stop19h 09m
Allegiant Air
Mon 9/219:00 am
TYS
-
COU
1 stop9h 32m
Allegiant Air
Deal found 6/7$284
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:04 pm
COU
-
TYS
1 stop8h 54m
Allegiant Air
Sun 10/43:08 pm
TYS
-
COU
1 stop23h 49m
Allegiant Air
Deal found 6/9$331
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:00 am
COU
-
TYS
1 stop5h 43m
American Airlines
Sat 6/275:33 pm
TYS
-
COU
1 stop5h 47m
American Airlines
Deal found 6/8$338
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:20 am
COU
-
TYS
1 stop4h 14m
American Airlines
Wed 8/51:21 pm
TYS
-
COU
1 stop5h 42m
American Airlines
Deal found 6/7$346
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/293:19 pm
COU
-
TYS
1 stop4h 41m
United Airlines
Wed 10/76:00 am
TYS
-
COU
1 stop5h 37m
United Airlines
Deal found 6/9$358

Find flight deals from Columbia to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$245
(Kiwi.com)
Provider with most accurate pricing for Columbia Regional-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-Knoxville McGhee Tyson flights.
Search Deals
From Columbia Regional to Knoxville McGhee Tyson
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
Use the filters below to find and compare flights from Columbia to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 7/11

10:49 am-11:54 pm

2 stops12h 05m

Knoxville McGhee Tyson

Sat 7/25

6:00 am-10:13 am

1 stop5h 13m

$292

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 6/23

6:00 am-12:43 pm

1 stop5h 43m

Knoxville McGhee Tyson

Sat 6/27

5:33 pm-10:20 pm

1 stop5h 47m

$338

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 7/29

10:32 am-9:33 pm

2 stops10h 01m

Knoxville McGhee Tyson

Wed 8/5

6:03 am-11:16 am

1 stop6h 13m

$400

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 7/17

3:25 pm-8:44 pm

1 stop4h 19m

Knoxville McGhee Tyson

Sun 7/19

6:00 am-10:13 am

1 stop5h 13m

$433

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 7/29

10:49 am-8:34 pm

2 stops8h 45m

Knoxville McGhee Tyson

Wed 8/5

5:45 am-2:50 pm

2 stops10h 05m

$489

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 6/25

10:49 am-11:54 pm

2 stops12h 05m

Knoxville McGhee Tyson

Mon 6/29

6:00 am-10:13 am

1 stop5h 13m

$515

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Fri 7/17

5:19 pm-11:51 pm

1 stop5h 32m

Knoxville McGhee Tyson

Sun 7/19

10:00 am-6:01 pm

2 stops9h 01m

$588

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Mon 6/22

3:25 pm-8:56 pm

1 stop4h 31m

Knoxville McGhee Tyson

Fri 6/26

7:19 pm-8:58 am

2 stops14h 39m

$681
Quickest round-trip

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sun 6/21

6:47 pm-11:53 pm

1 stop4h 06m

Knoxville McGhee Tyson

Thu 6/25

7:01 am-11:14 am

1 stop5h 13m

$686
Cheapest one-way
Quickest one-way

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sun 6/28

6:00 am-12:43 pm

1 stop5h 43m

$258

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/7

Sorted by cheapest first

Compare providers for flights from Columbia to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to Knoxville in June.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Columbia, Missouri-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Columbia, Missouri-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Columbia to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Columbia to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Columbia, Missouri to Knoxville?

    For as low as $338, United Airlines can have you in Knoxville from Columbia, Missouri in 5h 43m. Columbia, Missouri and Knoxville are separated by a distance of 497 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Columbia to Knoxville that include hotel bookings?

    Yes. In addition to deals on Columbia to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to Knoxville.

  • Can I find deals for business class flights from Columbia to Knoxville?

    Yes. Cheapflights offers flight deals from Columbia to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

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