$306+ Cheap flights from Knoxville to Columbia, MO (TYS - COU)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — COU
Oct 27 — Nov 31
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Columbia with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to ColumbiaExplore the most affordable flight options available from Knoxville to Columbia. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 27, 2026.
Explore the most affordable flight options available from Knoxville to Columbia. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 27, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:36 pm -
1 stop17h 38m
Mon 10/1912:29 pm -
1 stop8h 10m
Deal found 9/22![Allegiant Air logo]()
$306
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:06 pm -
1 stop5h 33m
Mon 10/196:24 pm -
1 stop4h 35m
Deal found 9/22![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
1 stop5h 39m
Mon 10/196:15 am -
2 stops7h 27m
Deal found 9/23![United Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:06 pm -
1 stop5h 33m
Tue 10/1310:40 am -
1 stop4h 22m
Deal found 9/24![American Airlines logo]()
$338
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/224:38 pm -
1 stop5h 17m
Thu 10/296:25 pm -
1 stop4h 34m
Deal found 9/24![American Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop5h 39m
Mon 10/196:15 am -
2 stops7h 27m
Deal found 9/22![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:38 pm -
1 stop5h 17m
Sun 10/186:00 am -
1 stop4h 05m
Deal found 9/22![American Airlines logo]()
$422
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:45 am -
2 stops10h 23m
Sun 10/183:19 pm -
1 stop4h 30m
Deal found 9/22![United Airlines logo]()
$506
Best flights from Knoxville to ColumbiaDiscover carefully curated flight deals from Knoxville to Columbia that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 27, 2026.
Discover carefully curated flight deals from Knoxville to Columbia that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 27, 2026.
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:49 pm -
1 stop6h 50m
Mon 10/196:24 pm -
1 stop4h 35m
Deal found 9/23![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
1 stop5h 39m
Mon 10/196:15 am -
2 stops7h 27m
Deal found 9/23![United Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/224:38 pm -
1 stop5h 17m
Thu 10/296:25 pm -
1 stop4h 34m
Deal found 9/24![American Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop5h 39m
Mon 10/196:15 am -
2 stops7h 27m
Deal found 9/22![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:38 pm -
1 stop5h 17m
Sun 10/186:00 am -
1 stop4h 05m
Deal found 9/22![American Airlines logo]()
$422
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:40 pm -
1 stop4h 43m
Wed 12/28:00 am -
2 stops12h 57m
Deal found 9/27![United Airlines logo]()
$439
Last-minute flights from Knoxville to ColumbiaDiscover last-minute flight deals from Knoxville to Columbia. Data last updated September 27, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Columbia. Data last updated September 27, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:06 pm -
1 stop5h 33m
Tue 10/1310:40 am -
1 stop4h 22m
Deal found 9/24![American Airlines logo]()
$338
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:36 pm -
1 stop17h 38m
Mon 10/1912:29 pm -
1 stop8h 10m
Deal found 9/22![Allegiant Air logo]()
$306
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
1 stop5h 39m
Mon 10/196:15 am -
2 stops7h 27m
Deal found 9/23![United Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:38 pm -
1 stop5h 17m
Sun 10/186:00 am -
1 stop4h 05m
Deal found 9/22![American Airlines logo]()
$422
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:45 am -
2 stops10h 23m
Sun 10/183:19 pm -
1 stop4h 30m
Deal found 9/22![United Airlines logo]()
$506
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:06 pm -
1 stop5h 33m
Mon 10/196:24 pm -
1 stop4h 35m
Deal found 9/22![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop5h 39m
Mon 10/196:15 am -
2 stops7h 27m
Deal found 9/22![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/224:38 pm -
1 stop5h 17m
Thu 10/296:25 pm -
1 stop4h 34m
Deal found 9/24![American Airlines logo]()
$343
Find flight deals from Knoxville to Columbia
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Columbia (COU). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $306 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Columbia that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 27, 2026.
Use the filters below to find and compare flights from Knoxville to Columbia that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleColumbia
TYS Knoxville McGhee Tyson - COU Columbia Regional
TYSCOU
Knoxville McGhee Tyson
Fri 10/16
4:49 pm-10:39 pm
1 stop6h 50m
Columbia Regional
Mon 10/19
6:24 pm-11:59 pm
1 stop4h 35m
$308
KnoxvilleColumbia
TYS Knoxville McGhee Tyson - COU Columbia Regional
TYSCOU
Knoxville McGhee Tyson
Thu 10/15
6:00 am-10:39 am
1 stop5h 39m
Columbia Regional
Mon 10/19
6:15 am-2:42 pm
2 stops7h 27m
$314
KnoxvilleColumbia
TYS Knoxville McGhee Tyson - COU Columbia Regional
TYSCOU
Knoxville McGhee Tyson
Thu 10/22
4:38 pm-8:55 pm
1 stop5h 17m
Columbia Regional
Thu 10/29
6:25 pm-11:59 pm
1 stop4h 34m
$343
KnoxvilleColumbia
TYS Knoxville McGhee Tyson - COU Columbia Regional
TYSCOU
Knoxville McGhee Tyson
Fri 10/16
6:00 am-10:39 am
1 stop5h 39m
Columbia Regional
Mon 10/19
6:15 am-2:42 pm
2 stops7h 27m
$374
Quickest round-trip
KnoxvilleColumbia
TYS Knoxville McGhee Tyson - COU Columbia Regional
TYSCOU
Knoxville McGhee Tyson
Thu 10/15
4:38 pm-8:55 pm
1 stop5h 17m
Columbia Regional
Sun 10/18
6:00 am-11:05 am
1 stop4h 05m
$422
KnoxvilleColumbia
TYS Knoxville McGhee Tyson - COU Columbia Regional
TYSCOU
Knoxville McGhee Tyson
Sat 11/21
5:40 pm-9:23 pm
1 stop4h 43m
Columbia Regional
Wed 12/2
8:00 am-9:57 pm
2 stops12h 57m
$439
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Knoxville-Columbia, Missouri flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Columbia, Missouri flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Columbia, Missouri flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Columbia, Missouri flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Columbia, Missouri flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Columbia
Have a flexible travel schedule? Discover the best time to fly to Columbia from Knoxville with our price prediction graph.
TYS-COU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Columbia
Get insights into the airlines that provide service to Columbia. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbia. Reviews last updated September 27, 2026.
Get a feel of what it's like to fly with American Airlines from Knoxville to Columbia by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.0
Comfort
7.2
Boarding
7.4
Crew
7.9
Entertainment
6.8
Food
6.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Overall
7.0
Comfort
7.2
Boarding
7.4
Crew
7.9
Entertainment
6.8
Food
6.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Columbia. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Columbia?
Book flights to Columbia if you plan to visit one of these locationsJefferson City
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Knoxville and Columbia flights
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Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 27, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Knoxville to Columbia
Discover the top airline that operate flights from Knoxville to Columbia. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$288 | Average$386 | FlexibilityNo cancel fee | On-time71% |