$138+ Cheap flights from Knoxville to St. Louis (TYS - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Jun 19 — Jun 261
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to St. Louis
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Best
Last-minute
One-way
Cheapest flights from Knoxville to St. LouisExplore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 20, 2026.
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:05 pm
TYS
- STL
1 stop26h 44m
Multiple Airlines
Thu 7/96:33 pm
STL
- TYS
2 stops26h 27m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2312:55 pm
TYS
- STL
2 stops20h 57m
Multiple Airlines
Tue 8/258:08 pm
STL
- TYS
1 stop22h 29m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2912:40 pm
TYS
- STL
2 stops29h 50m
Multiple Airlines
Mon 7/64:09 pm
STL
- TYS
1 stop6h 24m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:40 pm
TYS
- STL
2 stops29h 50m
Multiple Airlines
Mon 6/154:17 pm
STL
- TYS
1 stop6h 17m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/184:20 pm
TYS
- STL
1 stop8h 35m
Southwest
Tue 6/231:20 pm
STL
- TYS
1 stop6h 55m
Southwest
Deal found 5/17![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:20 pm
TYS
- STL
1 stop8h 35m
Southwest
Thu 7/95:35 pm
STL
- TYS
1 stop2h 35m
Southwest
Deal found 5/18![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/231:15 pm
TYS
- STL
2 stops8h 50m
Southwest
Tue 8/2510:45 am
STL
- TYS
2 stops7h 10m
Southwest
Deal found 5/18![Southwest logo]()
$295
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:45 pm
TYS
- STL
1 stop4h 00m
Southwest
Sun 6/288:25 am
STL
- TYS
1 stop7h 45m
Southwest
Deal found 5/17![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:40 am
TYS
- STL
2 stops9h 05m
Southwest
Fri 7/105:35 pm
STL
- TYS
1 stop2h 35m
Southwest
Deal found 5/19![Southwest logo]()
$300
Best flights from Knoxville to St. LouisDiscover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 20, 2026.
Discover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:05 pm
TYS
- STL
1 stop26h 44m
Multiple Airlines
Thu 7/96:33 pm
STL
- TYS
2 stops26h 27m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$254
This Southwest deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/235:55 pm
TYS
- STL
1 stop4h 10m
Southwest
Tue 8/257:15 am
STL
- TYS
1 stop3h 50m
Southwest
Deal found 5/18![Southwest logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2912:40 pm
TYS
- STL
2 stops29h 50m
Multiple Airlines
Mon 7/64:09 pm
STL
- TYS
1 stop6h 24m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$278
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:40 am
TYS
- STL
2 stops7h 05m
Southwest
Tue 6/231:20 pm
STL
- TYS
1 stop6h 55m
Southwest
Deal found 5/17![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:20 pm
TYS
- STL
1 stop8h 35m
Southwest
Thu 7/95:35 pm
STL
- TYS
1 stop2h 35m
Southwest
Deal found 5/18![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/297:45 pm
TYS
- STL
1 stop4h 00m
Southwest
Mon 7/65:35 pm
STL
- TYS
1 stop2h 35m
Southwest
Deal found 5/15![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:45 pm
TYS
- STL
1 stop4h 00m
Southwest
Sun 6/288:25 am
STL
- TYS
1 stop7h 45m
Southwest
Deal found 5/17![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/201:35 pm
TYS
- STL
1 stop4h 50m
Southwest
Mon 6/223:35 pm
STL
- TYS
2 stops5h 55m
Southwest
Deal found 5/19![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:40 am
TYS
- STL
2 stops7h 55m
Southwest
Tue 6/168:25 am
STL
- TYS
1 stop8h 55m
Southwest
Deal found 5/17![Southwest logo]()
$328
Last-minute flights from Knoxville to St. LouisDiscover last-minute flight deals from Knoxville to St. Louis. Data last updated May 20, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to St. Louis. Data last updated May 20, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:40 pm
TYS
- STL
2 stops29h 50m
Multiple Airlines
Mon 6/154:17 pm
STL
- TYS
1 stop6h 17m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$279
This Frontier deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/88:32 pm
TYS
- STL
1 stop23h 51m
Frontier
Tue 6/168:08 pm
STL
- TYS
1 stop22h 29m
Frontier
Deal found 5/17![Frontier logo]()
$314
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:40 am
TYS
- STL
2 stops7h 55m
Southwest
Tue 6/168:25 am
STL
- TYS
1 stop8h 55m
Southwest
Deal found 5/17![Southwest logo]()
$328
This Southwest deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:45 pm
TYS
- STL
1 stop4h 00m
Southwest
Thu 6/1811:30 am
STL
- TYS
1 stop6h 40m
Southwest
Deal found 5/16![Southwest logo]()
$338
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/184:20 pm
TYS
- STL
1 stop8h 35m
Southwest
Tue 6/231:20 pm
STL
- TYS
1 stop6h 55m
Southwest
Deal found 5/17![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/201:35 pm
TYS
- STL
1 stop4h 50m
Southwest
Mon 6/225:35 pm
STL
- TYS
1 stop2h 35m
Southwest
Deal found 5/19![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:45 pm
TYS
- STL
1 stop4h 00m
Southwest
Sun 6/288:25 am
STL
- TYS
1 stop7h 45m
Southwest
Deal found 5/17![Southwest logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2912:40 pm
TYS
- STL
2 stops29h 50m
Multiple Airlines
Mon 7/64:09 pm
STL
- TYS
1 stop6h 24m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$278
One-way flights from Knoxville to St. LouisSearch for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated May 20, 2026.
Search for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated May 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2312:55 pm
TYS
- STL
2 stops20h 57m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/49:20 pm
TYS
- STL
2 stops36h 35m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$140
This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/237:00 am
TYS
- STL
1 stop4h 12m
United Airlines
Deal found 5/18![United Airlines logo]()
$150
This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:05 am
TYS
- STL
2 stops6h 40m
Southwest
Deal found 5/19![Southwest logo]()
$155
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:43 pm
TYS
- STL
1 stop6h 33m
American Airlines
Deal found 5/18![American Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/158:43 pm
TYS
- STL
3 stops22h 11m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$306
Find flight deals from Knoxville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $254 (Kiwi.com) |
One-way from | $138 (Kiwi.com) |
Popular in | November |
Cheapest in | January |
Average price | $337 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 20, 2026.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Fri 7/3
10:05 pm-11:49 pm
1 stop26h 44m
Lambert-St Louis
Thu 7/9
6:33 pm-10:00 pm
2 stops26h 27m
$254
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Mon 6/29
12:40 pm-5:30 pm
2 stops29h 50m
Lambert-St Louis
Mon 7/6
4:09 pm-11:33 pm
1 stop6h 24m
$278
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sun 8/23
5:55 pm-9:05 pm
1 stop4h 10m
Lambert-St Louis
Tue 8/25
7:15 am-12:05 pm
1 stop3h 50m
$284
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Thu 6/18
6:40 am-12:45 pm
2 stops7h 05m
Lambert-St Louis
Tue 6/23
1:20 pm-9:15 pm
1 stop6h 55m
$289
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Fri 7/3
4:20 pm-11:55 pm
1 stop8h 35m
Lambert-St Louis
Thu 7/9
5:35 pm-9:10 pm
1 stop2h 35m
$294
Quickest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Mon 6/29
7:45 pm-10:45 pm
1 stop4h 00m
Lambert-St Louis
Mon 7/6
5:35 pm-9:10 pm
1 stop2h 35m
$294
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Thu 6/25
7:45 pm-10:45 pm
1 stop4h 00m
Lambert-St Louis
Sun 6/28
8:25 am-5:10 pm
1 stop7h 45m
$299
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sat 6/20
1:35 pm-5:25 pm
1 stop4h 50m
Lambert-St Louis
Mon 6/22
3:35 pm-10:30 pm
2 stops5h 55m
$304
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Mon 6/8
6:40 am-1:35 pm
2 stops7h 55m
Lambert-St Louis
Tue 6/16
8:25 am-6:20 pm
1 stop8h 55m
$328
Cheapest one-way
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sun 8/23
12:55 pm-8:52 am
2 stops20h 57m
$138
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Knoxville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
TYS-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to St. Louis
What is the cheapest month to book a flight from Knoxville to St. Louis?
Currently, January is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $294). Flying from Knoxville to St. Louis in November is currently the most expensive (average of $553). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated May 20, 2026.
Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Knoxville and St. Louis flights
Browse other Knoxville and St. Louis flight options. Last updated on May 20, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on May 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 20, 2026.
Top 2 airlines flying from Knoxville to St. Louis
Discover the top 2 airlines that operate flights from Knoxville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$363 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$302 | FlexibilityNo cancel fee | On-timeN/A |