$143+ Cheap flights from Knoxville to St. Louis (TYS - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Nov 18 — Nov 251
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to St. LouisExplore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/117:26 pm -
1 stop5h 39m
Mon 12/146:00 am -
1 stop4h 27m
Deal found 10/15![Delta logo]()
$243
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:30 pm -
1 stop7h 05m
Tue 11/245:00 am -
1 stop4h 58m
Deal found 10/15![American Airlines logo]()
$275
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:59 pm -
1 stop6h 16m
Mon 11/91:20 pm -
1 stop4h 26m
Deal found 10/16![American Airlines logo]()
$285
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:25 pm -
1 stop5h 30m
Wed 11/1110:55 am -
2 stops8h 55m
Deal found 10/15![Southwest logo]()
$290
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/257:00 am -
1 stop8h 20m
Fri 1/16:00 am -
1 stop4h 02m
Deal found 10/16![American Airlines logo]()
$292
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:59 pm -
1 stop6h 16m
Sun 11/1511:35 am -
1 stop3h 54m
Deal found 10/16![American Airlines logo]()
$296
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:34 pm -
1 stop4h 49m
Mon 11/235:30 pm -
1 stop3h 52m
Deal found 10/19![Delta logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:45 am -
2 stops28h 34m
Sun 11/154:26 pm -
1 stop26h 33m
Deal found 10/16![Multiple Airlines logo]()
$347
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:04 am -
1 stop5h 38m
Fri 1/19:35 am -
1 stop6h 40m
Deal found 10/15![United Airlines logo]()
$355
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:00 am -
1 stop5h 42m
Sun 12/208:22 am -
1 stop5h 20m
Deal found 10/16![United Airlines logo]()
$363
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:50 pm -
1 stop4h 11m
Sat 11/285:00 am -
1 stop4h 33m
Deal found 10/18![American Airlines logo]()
$364
Best flights from Knoxville to St. LouisDiscover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
Discover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/117:26 pm -
1 stop5h 39m
Mon 12/146:00 am -
1 stop4h 27m
Deal found 10/15![Delta logo]()
$243
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:00 am -
1 stop5h 42m
Sun 12/208:22 am -
1 stop5h 20m
Deal found 10/16![United Airlines logo]()
$363
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/218:55 am -
1 stop7h 55m
Tue 11/2410:10 am -
2 stops10h 35m
Deal found 10/15![Southwest logo]()
$437
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:34 pm -
1 stop4h 49m
Mon 11/235:30 pm -
1 stop3h 52m
Deal found 10/19![Delta logo]()
$298
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:00 am -
1 stop5h 42m
Sat 12/199:35 am -
1 stop6h 40m
Deal found 10/16![United Airlines logo]()
$459
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:40 pm -
2 stops9h 05m
Sat 11/285:25 am -
1 stop8h 05m
Deal found 10/18![Southwest logo]()
$479
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:25 am -
2 stops6h 20m
Wed 11/48:30 am -
2 stops10h 20m
Deal found 10/16![Southwest logo]()
$497
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:45 am -
1 stop6h 25m
Fri 10/302:55 pm -
1 stop6h 02m
Deal found 10/14![United Airlines logo]()
$577
Last-minute flights from Knoxville to St. LouisDiscover last-minute flight deals from Knoxville to St. Louis. Data last updated October 19, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to St. Louis. Data last updated October 19, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:59 pm -
1 stop6h 16m
Mon 11/91:20 pm -
1 stop4h 26m
Deal found 10/16![American Airlines logo]()
$285
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:25 pm -
1 stop5h 30m
Mon 11/91:05 pm -
2 stops6h 30m
Deal found 10/16![Southwest logo]()
$376
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:25 pm -
1 stop5h 30m
Wed 11/1110:55 am -
2 stops8h 55m
Deal found 10/15![Southwest logo]()
$290
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:59 pm -
1 stop6h 16m
Sun 11/1511:35 am -
1 stop3h 54m
Deal found 10/16![American Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:45 am -
2 stops28h 34m
Sun 11/154:26 pm -
1 stop26h 33m
Deal found 10/16![Multiple Airlines logo]()
$347
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:52 pm -
1 stop4h 07m
Tue 11/241:14 pm -
1 stop4h 38m
Deal found 10/18![American Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:08 pm -
2 stops24h 34m
Tue 11/246:05 pm -
1 stop15h 43m
Deal found 10/18![Multiple Airlines logo]()
$372
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:34 pm -
1 stop4h 49m
Mon 11/235:30 pm -
1 stop3h 52m
Deal found 10/19![Delta logo]()
$298
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:30 pm -
1 stop7h 05m
Tue 11/245:00 am -
1 stop4h 58m
Deal found 10/15![American Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:20 am -
1 stop29h 43m
Tue 11/246:05 pm -
1 stop15h 43m
Deal found 10/15![Multiple Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:50 pm -
1 stop4h 11m
Sat 11/285:00 am -
1 stop4h 33m
Deal found 10/18![American Airlines logo]()
$364
One-way flights from Knoxville to St. LouisSearch for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
Search for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/168:00 am -
1 stop6h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Southwest logo]()
$143
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/174:45 pm -
1 stop6h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Southwest logo]()
$154
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:40 am -
1 stop4h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Delta logo]()
$240
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:30 pm -
1 stop7h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![Southwest logo]()
$244
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:58 pm -
1 stop5h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![American Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:00 am -
2 stops11h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$282
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:15 am -
2 stops6h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Southwest logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/178:30 am -
3 stops53h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$287
Find flight deals from Knoxville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $243 (Delta) |
One-way from | $143 (Southwest) |
Popular in | September |
Cheapest in | January |
Average price | $374 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Sat 1/16
8:00 am-1:35 pm
1 stop6h 35m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$143
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Sun 1/17
7:00 am-3:05 pm
2 stops9h 05m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$159
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Fri 12/11
7:26 pm-12:05 am
1 stop5h 39m
Lambert-St Louis
Mon 12/14
6:00 am-11:27 am
1 stop4h 27m
$243
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Fri 10/30
5:30 pm-11:50 pm
1 stop7h 20m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$244
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Sat 11/7
12:35 pm-8:10 pm
2 stops8h 35m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$249
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Sat 10/24
7:58 pm-11:59 pm
1 stop5h 01m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$281
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Tue 10/27
7:30 am-12:35 pm
1 stop6h 05m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$281
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Mon 10/26
7:00 am-5:40 pm
2 stops11h 40m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$282
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Tue 10/27
7:15 am-1:05 pm
2 stops6h 50m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$286
Quickest round-trip
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Sat 10/24
4:11 pm-7:56 pm
1 stop4h 45m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$298
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Knoxville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
TYS-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to St. Louis
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 19, 2026.
Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Southwest,Delta, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Comfort
8.0
Overall
7.9
Boarding
8.1
Food
7.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Crew
8.6
Comfort
8.0
Overall
7.9
Boarding
8.1
Food
7.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Crew
8.6
Comfort
8.0
Overall
7.9
Boarding
8.1
Food
7.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Crew
8.6
Comfort
8.0
Overall
7.9
Boarding
8.1
Food
7.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Maryland Heights
Chesterfield
Collinsville
Edwardsville
Glencoe
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Knoxville
Popular flights
St. Louis flight routes
Alternative routes for Knoxville to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to St. Louis by cabin class
Find flights from Knoxville to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and St. Louis flights
Browse other Knoxville and St. Louis flight options. Last updated on October 19, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on October 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 19, 2026.
Top 3 airlines flying from Knoxville to St. Louis
Discover the top 3 airlines that operate flights from Knoxville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$167 | Average$382 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$337 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$258 | Average$350 | FlexibilityNo cancel fee | On-timeN/A |