What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $229. Other airlines that can offer you cheap pricing are American Airlines, from $329, and United Airlines, from $446. These flights start at 26% lower than the current average price 3 months from now.

What is the cheapest day to fly from Knoxville to St. Louis?

Travelers seeking maximum savings on their Knoxville to St. Louis flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the most popular airlines that fly from Knoxville to St. Louis?

Consider American Airlines, Delta or United Airlines when booking your flight. These represent the most popular airlines when flying from Knoxville to St. Louis.

What is the cheapest day to fly round-trip from Knoxville to St. Louis?

Sunday flights are found to be more expensive to fly from Knoxville to St. Louis. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to St. Louis.

What is the cheapest month to fly from Knoxville to St. Louis?

The best pricing can be found in the month of July. Prices to St. Louis from Knoxville average $313. You can even find prices in July for less than $313, as users have found deals to St. Louis from as low as $198. The month of March appears to be one of the more expensive times to travel to St. Louis from Knoxville. Flying in the targeted month can save you up to 73%.

Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.

Can I find deals for business class flights from Knoxville to St. Louis?

Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$145+ Flights from Knoxville to St. Louis

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Cheap flight deals from Knoxville to St. Louis

Round-trip from	$229 (Delta)
One-way from	$145 (FlightHub)
Popular in	March
Cheapest in	July
Average price	$238

From Knoxville McGhee Tyson to Lambert-St Louis

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One-way flight from Knoxville McGhee Tyson to Lambert-St Louis

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Highest demand for flights based on searches. 16% potential increase in price ($61 potential increase over avg. RT price).

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Cheapest flight prices on average. 7% potential price decrease ($22 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Knoxville to St. Louis

Cheapest flights from Knoxville to St. Louis
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Fri 8/15:57 pmTYS - STL

1 stop4h 45mDelta

Sun 8/36:00 amSTL - TYS

1 stop4h 08mDelta

Deal found 7/1

$229

Thu 7/36:39 pmTYS - STL

1 stop6h 11mAmerican Airlines

Wed 7/165:27 pmSTL - TYS

1 stop5h 25mAmerican Airlines

Deal found 7/2

$264

Thu 7/35:25 pmTYS - STL

1 stop16h 47mFrontier

Wed 7/167:29 pmSTL - TYS

1 stop20h 00mFrontier

Deal found 7/2

$332

Sat 7/198:10 amTYS - STL

2 stops26h 42mMultiple Airlines

Sun 7/205:26 pmSTL - TYS

1 stop13h 36mMultiple Airlines

Deal found 7/1

$349

Wed 9/177:25 pmTYS - STL

2 stops19h 54mUnited Airlines

Sun 9/216:15 amSTL - TYS

1 stop6h 23mUnited Airlines

Deal found 7/1

$446

Best flights from Knoxville to St. Louis
Discover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 3, 2025.

Fri 8/15:57 pmTYS - STL

1 stop4h 45mDelta

Sun 8/36:00 amSTL - TYS

1 stop4h 08mDelta

Deal found 7/1

$229

Sat 9/138:23 amTYS - STL

2 stops6h 08mAmerican Airlines

Sun 9/147:23 amSTL - TYS

1 stop6h 20mAmerican Airlines

Deal found 7/3

$329

Sat 7/198:10 amTYS - STL

2 stops26h 42mMultiple Airlines

Sun 7/205:26 pmSTL - TYS

1 stop13h 36mMultiple Airlines

Deal found 7/1

$349

Wed 9/177:25 pmTYS - STL

2 stops19h 54mUnited Airlines

Sun 9/216:15 amSTL - TYS

1 stop6h 23mUnited Airlines

Deal found 7/1

$446

Last-minute flights from Knoxville to St. Louis
Discover last-minute flight deals from Knoxville to St. Louis. Data last updated July 3, 2025 and is based on user searches.

Thu 7/36:39 pmTYS - STL

1 stop6h 11mAmerican Airlines

Wed 7/165:27 pmSTL - TYS

1 stop5h 25mAmerican Airlines

Deal found 7/2

$264

Thu 7/35:25 pmTYS - STL

1 stop16h 47mFrontier

Wed 7/167:29 pmSTL - TYS

1 stop20h 00mFrontier

Deal found 7/2

$332

Fri 7/116:22 pmTYS - STL

1 stop5h 35mAmerican Airlines

Sun 7/135:20 amSTL - TYS

1 stop4h 08mAmerican Airlines

Deal found 7/2

$524

Fri 7/116:00 amTYS - STL

3 stops13h 41mMultiple Airlines

Sun 7/135:26 pmSTL - TYS

1 stop13h 36mMultiple Airlines

Deal found 7/2

$538

Fri 7/112:30 pmTYS - STL

1 stop5h 30mUnited Airlines

Sun 7/135:30 pmSTL - TYS

2 stops15h 57mUnited Airlines

Deal found 7/2

$847

Sat 7/198:10 amTYS - STL

2 stops26h 42mMultiple Airlines

Sun 7/205:26 pmSTL - TYS

1 stop13h 36mMultiple Airlines

Deal found 7/1

$349

Fri 8/15:57 pmTYS - STL

1 stop4h 45mDelta

Sun 8/36:00 amSTL - TYS

1 stop4h 08mDelta

Deal found 7/1

$229

Mon 8/47:00 amTYS - STL

1 stop6h 27mUnited Airlines

Wed 8/68:00 amSTL - TYS

2 stops14h 59mUnited Airlines

Deal found 7/1

$537

One-way flights from Knoxville to St. Louis
Search for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated July 3, 2025.

Thu 7/175:25 pmTYS - STL

1 stop16h 46mFrontier

Deal found 7/1

$145

Thu 7/173:11 pmTYS - STL

3 stops19h 41mMultiple Airlines

Deal found 7/1

$203

Tue 7/84:02 pmTYS - STL

1 stop3h 45mDelta

Deal found 7/2

$369

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 8/1

5:57 pm-9:42 pm

1 stop4h 45m

Lambert-St Louis

Sun 8/3

6:00 am-11:08 am

1 stop4h 08m

$229

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Sat 7/19

8:10 am-9:52 am

2 stops26h 42m

Lambert-St Louis

Sun 7/20

5:26 pm-8:02 am

1 stop13h 36m

$349

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 9/17

7:25 pm-2:19 pm

2 stops19h 54m

Lambert-St Louis

Sun 9/21

6:15 am-1:38 pm

1 stop6h 23m

$446

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 7/17

5:25 pm-9:11 am

1 stop16h 46m

$145

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 7/17

3:11 pm-9:52 am

3 stops19h 41m

$203

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 7/8

4:02 pm-6:47 pm

1 stop3h 45m

$369

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to St. Louis

What is the cheapest month to book a flight from Knoxville to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $311). Flying from Knoxville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to STL?

A simple way to save on the total cost of your ticket is to fly from Knoxville to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 8% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing St. Louis

Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,982 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,861 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Frontier

5.9

Fair

3,286 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Knoxville to St. Louis round-trip?
Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $229. Other airlines that can offer you cheap pricing are American Airlines, from $329, and United Airlines, from $446. These flights start at 26% lower than the current average price 3 months from now.
Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?
Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.
Can I find deals for business class flights from Knoxville to St. Louis?
Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $311). Flying from Knoxville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

O'Fallon

Maryland Heights

Fairview Heights

Collinsville

Eureka

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Glencoe

Alton

Festus

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Farmington

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Top 3 airlines flying from Knoxville to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$198	Average$287	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$213	Average$288	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$228	Average$288	FlexibilityNo cancel fee	On-timeN/A

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$145+ Cheap flights from Knoxville to St. Louis (TYS - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/17. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Knoxville to St. Louis

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Knoxville to St. Louis

Cheapest flights from Knoxville to St. LouisExplore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.

Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to St. Louis

What is the cheapest month to book a flight from Knoxville to St. Louis?

What is the cheapest time of day to fly from TYS to STL?

Find hourly flight availability from Knoxville to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

Reviews of airlines servicing St. Louis

Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

How can I find direct flights from Knoxville to St. Louis?

Can I find deals for business class flights from Knoxville to St. Louis?

What is the cheapest month to book a flight from Knoxville to St. Louis?

Traveling to a place near Knoxville?

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Alternative routes for Knoxville to St. Louis

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Top 3 airlines flying from Knoxville to St. Louis

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Cheapest flights from Knoxville to St. Louis
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.