$106+ Cheap flights from Knoxville to St. Louis (TYS - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Aug 17 — Aug 241
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to St. Louis
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Best
Last-minute
One-way
Cheapest flights from Knoxville to St. LouisExplore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 18, 2026.
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 18, 2026.
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:25 pm
TYS
- STL
1 stop4h 30m
American Airlines
Mon 8/176:00 am
STL
- TYS
1 stop5h 51m
American Airlines
Deal found 7/13![American Airlines logo]()
$211
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:30 pm
TYS
- STL
1 stop5h 40m
Southwest
Mon 8/179:15 am
STL
- TYS
2 stops8h 20m
Southwest
Deal found 7/13![Southwest logo]()
$216
This American Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:06 pm
TYS
- STL
1 stop5h 36m
American Airlines
Mon 9/147:21 am
STL
- TYS
1 stop4h 09m
American Airlines
Deal found 7/17![American Airlines logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:00 am
TYS
- STL
1 stop13h 23m
Multiple Airlines
Sun 8/166:34 pm
STL
- TYS
2 stops26h 50m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$227
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:00 pm
TYS
- STL
2 stops7h 10m
Southwest
Mon 9/147:40 am
STL
- TYS
1 stop4h 45m
Southwest
Deal found 7/17![Southwest logo]()
$229
This Delta deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:00 pm
TYS
- STL
1 stop4h 33m
Delta
Sun 9/611:00 am
STL
- TYS
1 stop3h 30m
Delta
Deal found 7/17![Delta logo]()
$233
This American Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:52 pm
TYS
- STL
1 stop6h 22m
American Airlines
Sat 8/155:11 pm
STL
- TYS
1 stop5h 07m
American Airlines
Deal found 7/17![American Airlines logo]()
$237
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:45 pm
TYS
- STL
1 stop4h 41m
United Airlines
Tue 8/1112:59 pm
STL
- TYS
1 stop6h 54m
United Airlines
Deal found 7/16![United Airlines logo]()
$239
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1312:40 pm
TYS
- STL
2 stops7h 30m
Southwest
Sat 8/156:50 am
STL
- TYS
1 stop5h 25m
Southwest
Deal found 7/17![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:25 am
TYS
- STL
2 stops7h 35m
Southwest
Thu 10/291:00 pm
STL
- TYS
1 stop7h 30m
Southwest
Deal found 7/14![Southwest logo]()
$260
Best flights from Knoxville to St. LouisDiscover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 18, 2026.
Discover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 18, 2026.
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:30 pm
TYS
- STL
1 stop5h 40m
Southwest
Mon 8/179:15 am
STL
- TYS
2 stops8h 20m
Southwest
Deal found 7/13![Southwest logo]()
$216
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:45 pm
TYS
- STL
1 stop4h 41m
United Airlines
Tue 8/1112:59 pm
STL
- TYS
1 stop6h 54m
United Airlines
Deal found 7/16![United Airlines logo]()
$239
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:37 pm
TYS
- STL
1 stop4h 09m
Delta
Sun 10/187:20 pm
STL
- TYS
1 stop3h 39m
Delta
Deal found 7/15![Delta logo]()
$255
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:00 pm
TYS
- STL
2 stops7h 10m
Southwest
Mon 9/147:40 am
STL
- TYS
1 stop4h 45m
Southwest
Deal found 7/17![Southwest logo]()
$229
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1312:40 pm
TYS
- STL
2 stops7h 30m
Southwest
Sat 8/156:50 am
STL
- TYS
1 stop5h 25m
Southwest
Deal found 7/17![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/161:50 pm
TYS
- STL
1 stop6h 15m
Southwest
Sat 10/176:30 am
STL
- TYS
1 stop6h 45m
Southwest
Deal found 7/13![Southwest logo]()
$255
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:25 am
TYS
- STL
2 stops7h 35m
Southwest
Thu 10/291:00 pm
STL
- TYS
1 stop7h 30m
Southwest
Deal found 7/14![Southwest logo]()
$260
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:40 am
TYS
- STL
2 stops8h 00m
Southwest
Sun 10/186:20 am
STL
- TYS
1 stop8h 15m
Southwest
Deal found 7/15![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/512:30 pm
TYS
- STL
1 stop6h 40m
Southwest
Sun 9/68:30 am
STL
- TYS
2 stops9h 10m
Southwest
Deal found 7/17![Southwest logo]()
$295
Last-minute flights from Knoxville to St. LouisDiscover last-minute flight deals from Knoxville to St. Louis. Data last updated July 18, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to St. Louis. Data last updated July 18, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:45 pm
TYS
- STL
1 stop4h 41m
United Airlines
Tue 8/1112:59 pm
STL
- TYS
1 stop6h 54m
United Airlines
Deal found 7/16![United Airlines logo]()
$239
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:25 pm
TYS
- STL
1 stop4h 30m
American Airlines
Mon 8/176:00 am
STL
- TYS
1 stop5h 51m
American Airlines
Deal found 7/13![American Airlines logo]()
$211
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:30 pm
TYS
- STL
1 stop5h 40m
Southwest
Mon 8/179:15 am
STL
- TYS
2 stops8h 20m
Southwest
Deal found 7/13![Southwest logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:00 am
TYS
- STL
1 stop13h 23m
Multiple Airlines
Sun 8/166:34 pm
STL
- TYS
2 stops26h 50m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$227
This American Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:52 pm
TYS
- STL
1 stop6h 22m
American Airlines
Sat 8/155:11 pm
STL
- TYS
1 stop5h 07m
American Airlines
Deal found 7/17![American Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1312:40 pm
TYS
- STL
2 stops7h 30m
Southwest
Sat 8/156:50 am
STL
- TYS
1 stop5h 25m
Southwest
Deal found 7/17![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1312:40 pm
TYS
- STL
2 stops7h 30m
Southwest
Sun 8/1610:05 am
STL
- TYS
2 stops9h 40m
Southwest
Deal found 7/13![Southwest logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:29 pm
TYS
- STL
1 stop6h 30m
Multiple Airlines
Sun 8/166:34 pm
STL
- TYS
2 stops27h 10m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$273
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2910:40 am
TYS
- STL
1 stop5h 17m
United Airlines
Tue 9/18:50 am
STL
- TYS
1 stop7h 08m
United Airlines
Deal found 7/13![United Airlines logo]()
$281
One-way flights from Knoxville to St. LouisSearch for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated July 18, 2026.
Search for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated July 18, 2026.
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:00 am
TYS
- STL
1 stop7h 11m
United Airlines
Deal found 7/14![United Airlines logo]()
$106
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:50 am
TYS
- STL
2 stops7h 25m
Southwest
Deal found 7/14![Southwest logo]()
$111
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/201:00 pm
TYS
- STL
1 stop8h 00m
Southwest
Deal found 7/17![Southwest logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:45 am
TYS
- STL
2 stops26h 12m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:11 pm
TYS
- STL
2 stops16h 29m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$138
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:00 am
TYS
- STL
1 stop7h 11m
United Airlines
Deal found 7/15![United Airlines logo]()
$140
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:40 pm
TYS
- STL
1 stop5h 15m
Southwest
Deal found 7/13![Southwest logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/221:54 pm
TYS
- STL
3 stops50h 34m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$221
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/47:00 am
TYS
- STL
2 stops9h 10m
Southwest
Deal found 7/15![Southwest logo]()
$224
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1110:42 am
TYS
- STL
1 stop5h 39m
United Airlines
Deal found 7/13![United Airlines logo]()
$288
Find flight deals from Knoxville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $211 (United Airlines) |
One-way from | $106 (United Airlines) |
Popular in | November |
Cheapest in | January |
Average price | $350 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 18, 2026.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Tue 8/11
5:30 pm-10:10 pm
1 stop5h 40m
Lambert-St Louis
Mon 8/17
9:15 am-6:35 pm
2 stops8h 20m
$216
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Fri 9/11
1:00 pm-7:10 pm
2 stops7h 10m
Lambert-St Louis
Mon 9/14
7:40 am-1:25 pm
1 stop4h 45m
$229
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Tue 8/4
5:45 pm-9:26 pm
1 stop4h 41m
Lambert-St Louis
Tue 8/11
12:59 pm-8:53 pm
1 stop6h 54m
$239
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Thu 8/13
12:40 pm-7:10 pm
2 stops7h 30m
Lambert-St Louis
Sat 8/15
6:50 am-1:15 pm
1 stop5h 25m
$242
Quickest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sat 10/17
4:37 pm-7:46 pm
1 stop4h 09m
Lambert-St Louis
Sun 10/18
7:20 pm-11:59 pm
1 stop3h 39m
$255
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Fri 10/16
1:50 pm-7:05 pm
1 stop6h 15m
Lambert-St Louis
Sat 10/17
6:30 am-2:15 pm
1 stop6h 45m
$255
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sun 10/25
6:25 am-1:00 pm
2 stops7h 35m
Lambert-St Louis
Thu 10/29
1:00 pm-9:30 pm
1 stop7h 30m
$260
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sat 10/17
6:40 am-1:40 pm
2 stops8h 00m
Lambert-St Louis
Sun 10/18
6:20 am-3:35 pm
1 stop8h 15m
$294
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Sat 9/5
12:30 pm-6:10 pm
1 stop6h 40m
Lambert-St Louis
Sun 9/6
8:30 am-6:40 pm
2 stops9h 10m
$295
Cheapest one-way
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Tue 9/15
5:30 pm-10:10 pm
1 stop5h 40m
$106
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Knoxville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
TYS-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to St. Louis
What is the cheapest month to book a flight from Knoxville to St. Louis?
Currently, January is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $294). Flying from Knoxville to St. Louis in November is currently the most expensive (average of $557). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated July 18, 2026.
Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Southwest,Delta, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreAnonymous,Feb 2025
MCO - STL
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreAnonymous,Feb 2025
MCO - STL
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreAnonymous,Feb 2025
MCO - STL
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreAnonymous,Feb 2025
MCO - STL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Alton
Farmington
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$363 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$337 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$248 | Average$303 | FlexibilityNo cancel fee | On-timeN/A |