$129+ Cheap flights from Knoxville to St. Louis (TYS - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Oct 16 — Oct 231
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to St. Louis
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Best
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One-way
Cheapest flights from Knoxville to St. LouisExplore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
Explore the most affordable flight options available from Knoxville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:17 am -
1 stop6h 18m
Sat 10/1711:31 am -
1 stop5h 49m
Deal found 9/15![American Airlines logo]()
$205
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:04 pm -
1 stop4h 54m
Wed 11/186:00 am -
1 stop4h 01m
Deal found 9/15![American Airlines logo]()
$218
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:50 pm -
1 stop6h 50m
Wed 11/188:30 am -
2 stops10h 20m
Deal found 9/15![Southwest logo]()
$223
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:40 am -
1 stop6h 11m
Mon 10/196:00 am -
1 stop3h 54m
Deal found 9/14![Delta logo]()
$244
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:01 am -
1 stop4h 43m
Sun 11/225:02 am -
1 stop5h 09m
Deal found 9/15![American Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:25 pm -
1 stop5h 15m
Tue 10/137:05 am -
1 stop8h 35m
Deal found 9/13![Southwest logo]()
$269
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:32 pm -
1 stop7h 01m
Sun 11/85:00 am -
1 stop4h 55m
Deal found 9/15![American Airlines logo]()
$283
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am -
1 stop7h 02m
Sat 10/1711:31 am -
1 stop5h 49m
Deal found 9/11![American Airlines logo]()
$289
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:05 am -
2 stops9h 30m
Sun 11/224:30 pm -
1 stop3h 05m
Deal found 9/15![Southwest logo]()
$291
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 pm -
2 stops6h 15m
Mon 10/195:50 pm -
1 stop3h 55m
Deal found 9/14![Southwest logo]()
$294
Best flights from Knoxville to St. LouisDiscover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
Discover carefully curated flight deals from Knoxville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/92:15 pm -
1 stop5h 55m
Fri 1/155:35 am -
1 stop7h 25m
Deal found 9/15![Southwest logo]()
$239
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:40 am -
1 stop4h 15m
Fri 11/278:00 am -
1 stop6h 15m
Deal found 9/14![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:15 am -
1 stop7h 55m
Mon 10/261:08 pm -
1 stop6h 46m
Deal found 9/11![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
1 stop7h 03m
Wed 10/75:00 am -
1 stop4h 23m
Deal found 9/11![American Airlines logo]()
$387
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:05 am -
2 stops7h 40m
Sun 11/222:40 pm -
2 stops4h 55m
Deal found 9/15![Southwest logo]()
$306
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2410:35 am -
1 stop3h 48m
Sat 11/287:05 am -
1 stop3h 23m
Deal found 9/14![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:10 am -
2 stops12h 00m
Sun 11/85:10 am -
2 stops8h 50m
Deal found 9/15![Southwest logo]()
$318
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:40 am -
1 stop4h 15m
Sat 11/285:48 pm -
1 stop5h 09m
Deal found 9/14![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:00 am -
2 stops8h 50m
Mon 10/55:50 pm -
1 stop3h 55m
Deal found 9/13![Southwest logo]()
$382
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/68:20 am -
2 stops7h 35m
Wed 10/77:05 am -
1 stop8h 35m
Deal found 9/11![Southwest logo]()
$434
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:55 pm -
2 stops6h 05m
Sat 10/1710:05 am -
2 stops8h 35m
Deal found 9/11![Southwest logo]()
$450
Last-minute flights from Knoxville to St. LouisDiscover last-minute flight deals from Knoxville to St. Louis. Data last updated September 16, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to St. Louis. Data last updated September 16, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:25 pm -
1 stop5h 17m
Wed 10/77:00 am -
1 stop5h 40m
Deal found 9/15![Delta logo]()
$312
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:20 pm -
1 stop7h 55m
Sat 10/106:30 am -
1 stop6h 45m
Deal found 9/15![Southwest logo]()
$373
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:25 pm -
1 stop5h 15m
Tue 10/137:05 am -
1 stop8h 35m
Deal found 9/13![Southwest logo]()
$269
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am -
1 stop7h 02m
Sat 10/1711:31 am -
1 stop5h 49m
Deal found 9/11![American Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:17 am -
1 stop6h 18m
Sat 10/1711:31 am -
1 stop5h 49m
Deal found 9/15![American Airlines logo]()
$205
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:40 am -
1 stop6h 11m
Mon 10/196:00 am -
1 stop3h 54m
Deal found 9/14![Delta logo]()
$244
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 pm -
2 stops6h 15m
Mon 10/195:50 pm -
1 stop3h 55m
Deal found 9/14![Southwest logo]()
$294
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am -
1 stop7h 13m
Mon 10/262:55 pm -
1 stop6h 02m
Deal found 9/15![United Airlines logo]()
$328
One-way flights from Knoxville to St. LouisSearch for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
Search for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:26 pm -
1 stop7h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![American Airlines logo]()
$129
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
1 stop7h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![United Airlines logo]()
$145
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2410:35 am -
1 stop3h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Delta logo]()
$155
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:25 pm -
1 stop5h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Southwest logo]()
$160
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/68:20 am -
2 stops7h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Southwest logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/99:35 pm -
3 stops26h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$291
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:45 am -
2 stops13h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$483
Find flight deals from Knoxville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $205 (American Airlines) |
One-way from | $129 (American Airlines) |
Popular in | November |
Cheapest in | January |
Average price | $419 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
Use the filters below to find and compare flights from Knoxville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Fri 10/9
5:26 pm-11:42 pm
1 stop7h 16m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$129
Quickest round-trip
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Tue 11/24
10:35 am-1:23 pm
1 stop3h 48m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$155
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Fri 10/9
7:25 pm-12:40 am
2 stops6h 15m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$165
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Tue 10/6
8:20 am-3:00 pm
2 stops7h 40m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$209
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Sat 1/9
2:15 pm-7:10 pm
1 stop5h 55m
Lambert-St Louis
Fri 1/15
5:35 am-2:00 pm
1 stop7h 25m
$239
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Fri 10/9
9:35 pm-11:13 pm
3 stops26h 38m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$291
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Tue 11/17
7:05 am-1:45 pm
2 stops7h 40m
Lambert-St Louis
Sun 11/22
2:40 pm-8:35 pm
2 stops4h 55m
$306
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Sun 11/22
5:40 am-8:55 am
1 stop4h 15m
Lambert-St Louis
Fri 11/27
8:00 am-3:15 pm
1 stop6h 15m
$309
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Fri 11/6
8:10 am-7:10 pm
2 stops12h 00m
Lambert-St Louis
Sun 11/8
5:10 am-3:00 pm
2 stops8h 50m
$318
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Tue 11/24
10:35 am-1:23 pm
1 stop3h 48m
Lambert-St Louis
Sat 11/28
7:05 am-11:28 am
1 stop3h 23m
$329
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Knoxville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to St. Louis in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
TYS-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to St. Louis
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 16, 2026.
Read through reviews of airlines operating flights from Knoxville to St. Louis, such as Southwest,Delta, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Edwardsville
Glencoe
Chesterfield
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Knoxville and St. Louis flights
Browse other Knoxville and St. Louis flight options. Last updated on September 16, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 16, 2026.
Top 3 airlines flying from Knoxville to St. Louis
Discover the top 3 airlines that operate flights from Knoxville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$167 | Average$383 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$337 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$248 | Average$300 | FlexibilityNo cancel fee | On-timeN/A |