$122+ Cheap flights from Knoxville (TYS) to Missouri
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Oct 30 — Nov 61
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to MissouriExplore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 30, 2026.
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 30, 2026.
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:32 pm -
1 stop7h 01m
Mon 11/911:35 am -
1 stop6h 11m
Deal found 9/28![American Airlines logo]()
$243
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/42:40 pm -
1 stop7h 30m
Mon 11/92:40 pm -
2 stops4h 55m
Deal found 9/28![Southwest logo]()
$248
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:32 pm -
1 stop7h 02m
Mon 12/145:02 am -
1 stop5h 00m
Deal found 9/29![American Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:01 pm -
1 stop25h 15m
Mon 11/211:33 am -
1 stop9h 11m
Deal found 9/29![Allegiant Air logo]()
$257
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:10 am -
1 stop7h 30m
Sat 11/148:40 am -
2 stops8h 05m
Deal found 9/29![Southwest logo]()
$259
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2512:16 pm -
1 stop4h 47m
Fri 1/16:00 am -
1 stop6h 39m
Deal found 9/29![Delta logo]()
$265
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 pm -
2 stops6h 15m
Fri 10/301:00 pm -
1 stop7h 35m
Deal found 9/25![Southwest logo]()
$270
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:25 pm -
1 stop6h 51m
Sun 1/102:38 pm -
1 stop5h 08m
Deal found 9/26![American Airlines logo]()
$276
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:25 pm -
2 stops6h 15m
Wed 11/47:35 am -
1 stop3h 45m
Deal found 9/25![Southwest logo]()
$281
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/271:00 pm -
2 stops7h 00m
Tue 11/37:35 am -
1 stop3h 45m
Deal found 9/29![Southwest logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:45 am -
2 stops34h 55m
Wed 11/44:18 pm -
1 stop20h 01m
Deal found 9/29![Multiple Airlines logo]()
$287
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:00 am -
1 stop5h 26m
Tue 10/205:46 pm -
1 stop5h 13m
Deal found 9/26![United Airlines logo]()
$287
Best flights from Knoxville to MissouriDiscover carefully curated flight deals from Knoxville to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 30, 2026.
Discover carefully curated flight deals from Knoxville to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 30, 2026.
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:10 am -
1 stop7h 30m
Sat 11/148:40 am -
2 stops8h 05m
Deal found 9/29![Southwest logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:45 am -
2 stops34h 55m
Wed 11/44:18 pm -
1 stop20h 01m
Deal found 9/29![Multiple Airlines logo]()
$287
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:49 pm -
1 stop6h 50m
Mon 10/195:14 pm -
1 stop5h 04m
Deal found 9/25![American Airlines logo]()
$308
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:09 am -
1 stop4h 42m
Thu 11/56:00 am -
1 stop6h 31m
Deal found 9/29![Delta logo]()
$321
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:15 am -
1 stop7h 55m
Mon 10/261:08 pm -
1 stop6h 46m
Deal found 9/26![United Airlines logo]()
$333
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/241:00 pm -
1 stop5h 40m
Sun 1/106:05 am -
2 stops6h 55m
Deal found 9/26![Southwest logo]()
$292
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:00 pm -
1 stop7h 10m
Sun 11/1510:32 am -
1 stop5h 50m
Deal found 9/30![Delta logo]()
$327
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:50 pm -
2 stops9h 30m
Sun 11/85:10 am -
2 stops8h 50m
Deal found 9/25![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
1 stop5h 39m
Sat 10/173:19 pm -
1 stop4h 30m
Deal found 9/28![United Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:06 pm -
1 stop6h 29m
Sun 10/255:40 am -
1 stop4h 14m
Deal found 9/27![Delta logo]()
$347
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:35 pm -
1 stop6h 20m
Fri 11/271:05 pm -
2 stops6h 30m
Deal found 9/28![Southwest logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:40 pm -
1 stop6h 18m
Mon 11/23:00 pm -
2 stops7h 59m
Deal found 9/29![United Airlines logo]()
$372
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/56:40 am -
1 stop6h 44m
Wed 1/69:43 am -
1 stop6h 20m
Deal found 9/29![United Airlines logo]()
$387
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:15 am -
2 stops8h 45m
Mon 11/212:40 pm -
2 stops6h 50m
Deal found 9/28![Southwest logo]()
$389
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:53 pm -
1 stop7h 51m
Wed 10/286:10 am -
1 stop8h 42m
Deal found 9/29![United Airlines logo]()
$401
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:40 am -
1 stop4h 29m
Sun 11/16:00 am -
1 stop6h 31m
Deal found 9/26![Delta logo]()
$464
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:45 am -
2 stops9h 33m
Tue 11/33:00 pm -
1 stop4h 54m
Deal found 9/29![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:45 am -
2 stops9h 48m
Sat 11/147:35 am -
2 stops11h 01m
Deal found 9/26![United Airlines logo]()
$408
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:55 pm -
2 stops6h 05m
Wed 10/144:30 pm -
1 stop3h 35m
Deal found 9/25![Southwest logo]()
$472
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:45 am -
2 stops9h 33m
Sat 10/318:00 am -
2 stops10h 36m
Deal found 9/29![United Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/134:20 pm -
1 stop7h 55m
Sat 10/178:55 am -
2 stops8h 00m
Deal found 9/28![Southwest logo]()
$472
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:45 am -
2 stops8h 45m
Sun 11/157:36 am -
1 stop4h 37m
Deal found 9/28![United Airlines logo]()
$432
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2212:11 pm -
2 stops12h 17m
Sat 2/2711:30 am -
1 stop4h 18m
Deal found 9/29![United Airlines logo]()
$432
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:40 pm -
1 stop4h 43m
Wed 12/28:00 am -
2 stops12h 57m
Deal found 9/27![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/812:00 pm -
1 stop5h 03m
Mon 1/113:10 pm -
1 stop6h 04m
Deal found 9/27![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:20 am -
2 stops11h 35m
Mon 11/22:55 pm -
1 stop6h 02m
Deal found 9/29![United Airlines logo]()
$444
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/126:15 am -
2 stops9h 19m
Sat 1/167:35 am -
2 stops11h 16m
Deal found 9/26![United Airlines logo]()
$449
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:40 pm -
1 stop4h 43m
Tue 12/13:04 pm -
2 stops7h 55m
Deal found 9/27![United Airlines logo]()
$467
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop5h 39m
Mon 10/196:15 am -
2 stops7h 27m
Deal found 9/25![United Airlines logo]()
$484
Last-minute flights from Knoxville to MissouriDiscover last-minute flight deals from Knoxville to Missouri. Data last updated September 30, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Missouri. Data last updated September 30, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:45 pm -
1 stop5h 09m
Fri 10/3012:00 pm -
1 stop4h 28m
Deal found 9/25![Delta logo]()
$265
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 pm -
2 stops6h 15m
Fri 10/301:00 pm -
1 stop7h 35m
Deal found 9/25![Southwest logo]()
$270
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:00 am -
1 stop5h 26m
Tue 10/205:46 pm -
1 stop5h 13m
Deal found 9/26![United Airlines logo]()
$287
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:42 am -
1 stop4h 36m
Sat 10/243:14 pm -
2 stops7h 45m
Deal found 9/27![United Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:35 am -
1 stop6h 18m
Tue 11/31:20 pm -
1 stop4h 26m
Deal found 9/29![American Airlines logo]()
$243
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/271:00 pm -
2 stops7h 00m
Tue 11/37:35 am -
1 stop3h 45m
Deal found 9/29![Southwest logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:01 pm -
1 stop25h 15m
Mon 11/211:33 am -
1 stop9h 11m
Deal found 9/29![Allegiant Air logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:45 am -
2 stops34h 55m
Wed 11/44:18 pm -
1 stop20h 01m
Deal found 9/29![Multiple Airlines logo]()
$287
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:45 am -
2 stops7h 38m
Mon 11/25:50 pm -
1 stop5h 09m
Deal found 9/28![United Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop14h 17m
Sat 10/318:43 pm -
1 stop16h 28m
Deal found 9/28![Multiple Airlines logo]()
$295
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:26 pm -
1 stop5h 33m
Wed 11/410:35 am -
1 stop5h 13m
Deal found 9/25![American Airlines logo]()
$254
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:25 pm -
2 stops6h 15m
Wed 11/47:35 am -
1 stop3h 45m
Deal found 9/25![Southwest logo]()
$281
One-way flights from Knoxville to MissouriSearch for one-way flight options from Knoxville to Missouri. Find affordable one-way fares based on user searches. Data last updated September 30, 2026.
Search for one-way flight options from Knoxville to Missouri. Find affordable one-way fares based on user searches. Data last updated September 30, 2026.
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:09 am -
1 stop4h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Delta logo]()
$122
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:04 pm -
1 stop4h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![American Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:15 am -
1 stop27h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Allegiant Air logo]()
$133
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:50 am -
2 stops10h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Southwest logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:45 am -
2 stops37h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$143
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:15 am -
1 stop8h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![United Airlines logo]()
$144
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:35 pm -
2 stops9h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![United Airlines logo]()
$149
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/248:35 am -
1 stop5h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Delta logo]()
$155
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:45 am -
2 stops9h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![United Airlines logo]()
$157
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:23 pm -
1 stop4h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Delta logo]()
$158
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:10 am -
2 stops12h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Southwest logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:41 pm -
2 stops23h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$169
Find flight deals from Knoxville to Missouri
Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated September 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $243 (American Airlines) |
One-way from | $122 (Delta) |
Popular in | November |
Cheapest in | January |
Average price | $419 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 30, 2026.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Sat 10/24
7:09 am-10:51 am
1 stop4h 42m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$122
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Thu 11/26
6:00 am-12:10 pm
1 stop7h 10m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$122
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Fri 11/27
8:04 pm-11:58 pm
1 stop4h 54m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$133
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Thu 11/26
7:50 am-4:55 pm
2 stops10h 05m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$138
KnoxvilleKansas City
TYS Knoxville McGhee Tyson - MCI Kansas City
TYSMCI
Knoxville McGhee Tyson
Wed 10/21
7:15 am-2:22 pm
1 stop8h 07m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$144
KnoxvilleKansas City
TYS Knoxville McGhee Tyson - MCI Kansas City
TYSMCI
Knoxville McGhee Tyson
Wed 10/21
2:38 pm-7:03 pm
1 stop5h 25m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$144
KnoxvilleKansas City
TYS Knoxville McGhee Tyson - MCI Kansas City
TYSMCI
Knoxville McGhee Tyson
Sat 10/24
6:56 am-1:05 pm
1 stop7h 09m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$144
KnoxvilleKansas City
TYS Knoxville McGhee Tyson - MCI Kansas City
TYSMCI
Knoxville McGhee Tyson
Tue 10/27
1:55 pm-7:55 pm
1 stop7h 00m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$144
KnoxvilleKansas City
TYS Knoxville McGhee Tyson - MCI Kansas City
TYSMCI
Knoxville McGhee Tyson
Tue 10/20
2:38 pm-7:03 pm
1 stop5h 25m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$144
KnoxvilleKansas City
TYS Knoxville McGhee Tyson - MCI Kansas City
TYSMCI
Knoxville McGhee Tyson
Thu 10/22
7:30 am-11:49 am
1 stop5h 19m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$144
Showing 1-10 of 52 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
TYS-STL
TYS-COU
TYS-MCI
TYS-SGF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Missouri
TYS-USMO
TYS-STL
TYS-COU
TYS-MCI
TYS-SGF
What is the cheapest month to book a flight from Knoxville to Missouri?
Currently, June is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $308). Flying from Knoxville to Missouri in February is currently the most expensive (average of $516). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Missouri?
Airfare is below average for this route at the moment.
Knoxville to Missouri flights typically cost between $278 and $532 in November.The cheapest round-trip price found within the last 5 days was $243 on American Airlines (Nov 4-Nov 9).
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated September 30, 2026.
See what other customers who have flown with Southwest,Delta, andAmerican Airlines from Knoxville to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Food
7.0
Overall
8.0
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Food
7.0
Overall
8.0
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Food
7.0
Overall
8.0
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Food
7.0
Overall
8.0
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Related info for your journey
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Complete your trip
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Knoxville and Missouri flights
Browse other Knoxville and Missouri flight options. Last updated on September 30, 2026.
Popular flight searches
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Knoxville to Missouri flights
Consider these flights traveling from Knoxville to Missouri.
Top 3 airlines flying from Knoxville to Missouri
Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$167 | Average$411 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$357 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$266 | Average$360 | FlexibilityNo cancel fee | On-timeN/A |