$103+ Cheap flights from Knoxville (TYS) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Sep 13 — Sep 201
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to MissouriExplore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2026.
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2026.
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:40 am -
1 stop5h 40m
Thu 9/107:00 am -
1 stop4h 53m
Deal found 8/12![American Airlines logo]()
$205
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:25 pm -
1 stop5h 30m
Tue 11/108:25 am -
1 stop4h 40m
Deal found 8/10![Southwest logo]()
$206
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:00 am -
1 stop6h 03m
Fri 9/1110:53 am -
1 stop5h 05m
Deal found 8/13![United Airlines logo]()
$208
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:15 am -
1 stop4h 05m
Tue 10/207:05 am -
1 stop8h 35m
Deal found 8/10![Southwest logo]()
$211
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:00 am -
1 stop3h 53m
Tue 11/105:37 pm -
1 stop3h 45m
Deal found 8/12![Delta logo]()
$213
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:15 am -
1 stop5h 17m
Sun 9/65:00 am -
1 stop5h 06m
Deal found 8/11![American Airlines logo]()
$231
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:50 pm -
2 stops9h 10m
Sat 10/176:30 am -
1 stop6h 45m
Deal found 8/12![Southwest logo]()
$236
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop7h 18m
Tue 9/298:02 am -
1 stop4h 51m
Deal found 8/13![American Airlines logo]()
$239
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop5h 40m
Wed 9/162:14 pm -
1 stop7h 28m
Deal found 8/13![American Airlines logo]()
$240
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:25 pm -
1 stop5h 30m
Thu 11/125:40 am -
1 stop8h 20m
Deal found 8/14![Southwest logo]()
$248
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:06 pm -
1 stop4h 08m
Tue 10/2010:33 am -
1 stop5h 54m
Deal found 8/13![Delta logo]()
$249
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:10 am -
2 stops9h 20m
Thu 11/128:55 pm -
1 stop11h 25m
Deal found 8/12![Southwest logo]()
$250
Best flights from Knoxville to MissouriDiscover carefully curated flight deals from Knoxville to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2026.
Discover carefully curated flight deals from Knoxville to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2026.
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:25 pm -
1 stop5h 30m
Tue 11/108:25 am -
1 stop4h 40m
Deal found 8/10![Southwest logo]()
$206
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:00 am -
1 stop6h 03m
Fri 9/1110:53 am -
1 stop5h 05m
Deal found 8/13![United Airlines logo]()
$208
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:06 pm -
1 stop5h 20m
Mon 10/125:31 pm -
1 stop5h 28m
Deal found 8/13![Delta logo]()
$239
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:55 pm -
1 stop4h 47m
Mon 11/24:36 pm -
1 stop5h 55m
Deal found 8/12![American Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:00 am -
2 stops29h 52m
Thu 9/173:51 pm -
1 stop5h 05m
Deal found 8/13![Multiple Airlines logo]()
$427
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:02 pm -
1 stop4h 58m
Mon 9/79:30 am -
1 stop6h 28m
Deal found 8/12![United Airlines logo]()
$231
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:06 pm -
1 stop4h 08m
Tue 10/132:39 pm -
1 stop4h 29m
Deal found 8/13![Delta logo]()
$239
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:10 am -
2 stops9h 20m
Thu 11/128:55 pm -
1 stop11h 25m
Deal found 8/12![Southwest logo]()
$250
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:40 pm -
1 stop5h 11m
Thu 11/121:45 pm -
1 stop7h 44m
Deal found 8/12![United Airlines logo]()
$239
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:55 pm -
1 stop8h 45m
Fri 9/115:15 am -
2 stops6h 05m
Deal found 8/13![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:10 am -
1 stop5h 05m
Fri 11/278:00 am -
1 stop4h 55m
Deal found 8/12![Delta logo]()
$294
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:45 am -
1 stop6h 25m
Mon 11/21:08 pm -
1 stop6h 46m
Deal found 8/13![United Airlines logo]()
$278
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2912:30 pm -
1 stop6h 40m
Wed 9/210:45 am -
2 stops8h 05m
Deal found 8/14![Southwest logo]()
$284
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:07 pm -
1 stop6h 35m
Sun 10/185:08 pm -
1 stop5h 51m
Deal found 8/12![American Airlines logo]()
$393
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:45 pm -
1 stop8h 10m
Thu 9/175:10 am -
1 stop11h 00m
Deal found 8/10![Southwest logo]()
$302
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1111:59 am -
1 stop5h 56m
Sun 11/159:00 am -
1 stop6h 03m
Deal found 8/13![United Airlines logo]()
$303
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:30 am -
1 stop5h 59m
Mon 9/213:45 pm -
1 stop5h 57m
Deal found 8/10![American Airlines logo]()
$403
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:50 am -
2 stops8h 00m
Tue 9/299:20 am -
2 stops9h 35m
Deal found 8/13![Southwest logo]()
$304
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2610:42 am -
1 stop6h 11m
Tue 9/295:46 pm -
1 stop5h 13m
Deal found 8/12![United Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
1 stop5h 26m
Sun 10/46:00 am -
2 stops7h 42m
Deal found 8/11![United Airlines logo]()
$332
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:00 am -
2 stops7h 30m
Wed 9/910:45 am -
2 stops8h 10m
Deal found 8/13![Southwest logo]()
$346
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:00 am -
1 stop6h 20m
Sat 9/56:00 am -
1 stop6h 18m
Deal found 8/13![United Airlines logo]()
$350
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:02 pm -
1 stop6h 17m
Sat 8/297:30 am -
2 stops11h 54m
Deal found 8/10![United Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:59 am -
1 stop5h 10m
Mon 11/23:15 pm -
2 stops7h 44m
Deal found 8/12![United Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:00 pm -
2 stops11h 19m
Mon 8/316:25 am -
1 stop5h 55m
Deal found 8/12![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:21 pm -
2 stops9h 58m
Mon 8/317:30 am -
1 stop4h 47m
Deal found 8/10![United Airlines logo]()
$440
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:02 pm -
1 stop6h 17m
Sun 9/611:23 am -
2 stops11h 36m
Deal found 8/11![United Airlines logo]()
$444
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/274:50 pm -
1 stop7h 54m
Fri 8/288:30 am -
1 stop24h 27m
Deal found 8/10![United Airlines logo]()
$574
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:00 am -
1 stop13h 46m
Fri 9/117:30 am -
1 stop25h 24m
Deal found 8/9![United Airlines logo]()
$844
Last-minute flights from Knoxville to MissouriDiscover last-minute flight deals from Knoxville to Missouri. Data last updated August 14, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Missouri. Data last updated August 14, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:40 am -
1 stop5h 40m
Thu 9/107:00 am -
1 stop4h 53m
Deal found 8/12![American Airlines logo]()
$205
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:15 am -
1 stop5h 17m
Sun 9/65:00 am -
1 stop5h 06m
Deal found 8/11![American Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/312:52 pm -
2 stops29h 30m
Thu 9/106:39 pm -
1 stop17h 02m
Deal found 8/11![Multiple Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:45 pm -
1 stop5h 55m
Tue 9/86:25 am -
1 stop6h 55m
Deal found 8/12![Southwest logo]()
$288
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:00 am -
1 stop6h 03m
Fri 9/1110:53 am -
1 stop5h 05m
Deal found 8/13![United Airlines logo]()
$208
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:55 pm -
1 stop8h 45m
Fri 9/115:15 am -
2 stops6h 05m
Deal found 8/13![Southwest logo]()
$274
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:00 am -
1 stop6h 02m
Wed 9/98:00 am -
1 stop4h 18m
Deal found 8/13![United Airlines logo]()
$216
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:34 am -
1 stop6h 20m
Sun 9/137:00 am -
1 stop4h 53m
Deal found 8/9![American Airlines logo]()
$260
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop5h 40m
Wed 9/162:14 pm -
1 stop7h 28m
Deal found 8/13![American Airlines logo]()
$240
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:55 pm -
1 stop5h 00m
Wed 9/1610:45 am -
2 stops8h 10m
Deal found 8/12![Southwest logo]()
$272
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop7h 18m
Tue 9/298:02 am -
1 stop4h 51m
Deal found 8/13![American Airlines logo]()
$239
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:50 am -
2 stops9h 40m
Wed 9/3010:45 am -
2 stops7h 15m
Deal found 8/10![Southwest logo]()
$268
One-way flights from Knoxville to MissouriSearch for one-way flight options from Knoxville to Missouri. Find affordable one-way fares based on user searches. Data last updated August 14, 2026.
Search for one-way flight options from Knoxville to Missouri. Find affordable one-way fares based on user searches. Data last updated August 14, 2026.
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:45 pm -
1 stop5h 25m
Deal found 8/11![Southwest logo]()
$103
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/158:05 am -
2 stops8h 05m
Deal found 8/12![Southwest logo]()
$108
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/238:10 am -
1 stop7h 30m
Deal found 8/10![Southwest logo]()
$109
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/22:55 pm -
1 stop8h 07m
Deal found 8/10![American Airlines logo]()
$120
This Trip.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:00 am -
1 stop6h 53m
Deal found 8/10![Multiple Airlines logo]()
$123
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:00 am -
2 stops7h 30m
Deal found 8/11![Southwest logo]()
$125
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/25:15 pm -
2 stops5h 50m
Deal found 8/10![Southwest logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:33 pm -
2 stops40h 07m
Deal found 8/10![Multiple Airlines logo]()
$130
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 am -
1 stop7h 13m
Deal found 8/10![United Airlines logo]()
$134
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2910:40 am -
1 stop5h 51m
Deal found 8/10![United Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:29 pm -
1 stop16h 04m
Deal found 8/12![Allegiant Air logo]()
$143
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:50 am -
2 stops9h 40m
Deal found 8/10![Southwest logo]()
$145
Find flight deals from Knoxville to Missouri
Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated August 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $205 (American Airlines) |
One-way from | $103 (Southwest) |
Popular in | December |
Cheapest in | August |
Average price | $295 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Mon 11/2
7:25 pm-11:55 pm
1 stop5h 30m
Lambert-St Louis
Tue 11/10
8:25 am-2:05 pm
1 stop4h 40m
$206
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Sat 9/5
7:00 am-12:03 pm
1 stop6h 03m
Lambert-St Louis
Fri 9/11
10:53 am-4:58 pm
1 stop5h 05m
$208
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Fri 9/4
6:02 pm-10:00 pm
1 stop4h 58m
Lambert-St Louis
Mon 9/7
9:30 am-4:58 pm
1 stop6h 28m
$231
KnoxvilleKansas City
TYS Knoxville McGhee Tyson - MCI Kansas City
TYSMCI
Knoxville McGhee Tyson
Thu 10/8
12:06 pm-4:26 pm
1 stop5h 20m
Kansas City
Mon 10/12
5:31 pm-11:59 pm
1 stop5h 28m
$239
Quickest round-trip
KnoxvilleKansas City
TYS Knoxville McGhee Tyson - MCI Kansas City
TYSMCI
Knoxville McGhee Tyson
Thu 10/8
12:06 pm-3:14 pm
1 stop4h 08m
Kansas City
Tue 10/13
2:39 pm-8:08 pm
1 stop4h 29m
$239
KnoxvilleKansas City
TYS Knoxville McGhee Tyson - MCI Kansas City
TYSMCI
Knoxville McGhee Tyson
Sat 11/7
5:40 pm-9:51 pm
1 stop5h 11m
Kansas City
Thu 11/12
1:45 pm-10:29 pm
1 stop7h 44m
$239
KnoxvilleKansas City
TYS Knoxville McGhee Tyson - MCI Kansas City
TYSMCI
Knoxville McGhee Tyson
Sat 11/7
7:10 am-3:30 pm
2 stops9h 20m
Kansas City
Thu 11/12
8:55 pm-9:20 am
1 stop11h 25m
$250
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Sat 9/5
1:55 pm-9:40 pm
1 stop8h 45m
Lambert-St Louis
Fri 9/11
5:15 am-12:20 pm
2 stops6h 05m
$274
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Fri 10/30
6:45 am-12:10 pm
1 stop6h 25m
Lambert-St Louis
Mon 11/2
1:08 pm-8:54 pm
1 stop6h 46m
$278
KnoxvilleSt. Louis
TYS Knoxville McGhee Tyson - STL Lambert-St Louis
TYSSTL
Knoxville McGhee Tyson
Sat 8/29
12:30 pm-6:10 pm
1 stop6h 40m
Lambert-St Louis
Wed 9/2
10:45 am-7:50 pm
2 stops8h 05m
$284
Showing 1-10 of 51 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
TYS-STL
TYS-MCI
TYS-SGF
TYS-JLN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Missouri
TYS-USMO
TYS-STL
TYS-MCI
TYS-SGF
TYS-JLN
What is the cheapest month to book a flight from Knoxville to Missouri?
Currently, June is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $308). Flying from Knoxville to Missouri in February is currently the most expensive (average of $516). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated August 14, 2026.
See what other customers who have flown with Southwest,Delta, andAmerican Airlines from Knoxville to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Comfort
8.0
Reviews
1 / 20
2.0
MediocreAnonymous,Feb 2025
MCO - STL
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Comfort
8.0
Reviews
1 / 20
2.0
MediocreAnonymous,Feb 2025
MCO - STL
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Comfort
8.0
Reviews
1 / 20
2.0
MediocreAnonymous,Feb 2025
MCO - STL
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Comfort
8.0
Reviews
1 / 20
2.0
MediocreAnonymous,Feb 2025
MCO - STL
Related info for your journey
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Knoxville and Missouri flights
Browse other Knoxville and Missouri flight options. Last updated on August 14, 2026.
Popular flight searches
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Knoxville to Missouri flights
Consider these flights traveling from Knoxville to Missouri.
Top 3 airlines flying from Knoxville to Missouri
Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$403 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$357 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$248 | Average$359 | FlexibilityNo cancel fee | On-timeN/A |