$98+ Cheap flights from Knoxville (TYS) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
May 31 — Jun 71
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to MissouriExplore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2912:55 pm
TYS
- STL
2 stops21h 00m
Multiple Airlines
Tue 6/24:19 pm
STL
- TYS
1 stop25h 02m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$243
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:15 am
TYS
- STL
1 stop8h 00m
Southwest
Tue 5/265:45 am
STL
- TYS
1 stop7h 35m
Southwest
Deal found 4/27![Southwest logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1012:40 pm
TYS
- MCI
2 stops29h 41m
Multiple Airlines
Mon 7/1310:40 am
MCI
- TYS
1 stop11h 39m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$250
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:50 pm
TYS
- STL
1 stop5h 10m
Southwest
Sat 5/306:20 am
STL
- TYS
1 stop6h 00m
Southwest
Deal found 4/27![Southwest logo]()
$263
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:45 pm
TYS
- STL
1 stop3h 10m
Southwest
Tue 6/22:30 pm
STL
- TYS
1 stop4h 10m
Southwest
Deal found 4/27![Southwest logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- STL
1 stop12h 06m
Multiple Airlines
Mon 5/255:27 pm
STL
- TYS
2 stops21h 48m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$275
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:45 pm
TYS
- STL
1 stop5h 10m
Southwest
Mon 6/12:10 pm
STL
- TYS
1 stop5h 10m
Southwest
Deal found 4/27![Southwest logo]()
$277
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:40 am
TYS
- STL
2 stops7h 55m
Southwest
Wed 6/2410:20 am
STL
- TYS
1 stop5h 40m
Southwest
Deal found 4/30![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:50 pm
TYS
- STL
2 stops7h 25m
Southwest
Thu 6/412:40 pm
STL
- TYS
2 stops8h 50m
Southwest
Deal found 4/30![Southwest logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1212:49 pm
TYS
- MCI
2 stops29h 32m
Multiple Airlines
Fri 6/197:39 pm
MCI
- TYS
1 stop11h 31m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:08 pm
TYS
- MCI
1 stop16h 42m
Allegiant Air
Mon 7/1310:40 am
MCI
- TYS
1 stop11h 39m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$294
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:33 pm
TYS
- MCI
1 stop7h 53m
American Airlines
Tue 6/25:16 pm
MCI
- TYS
1 stop5h 31m
American Airlines
Deal found 4/27![American Airlines logo]()
$295
Best flights from Knoxville to MissouriDiscover carefully curated flight deals from Knoxville to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2026.
Discover carefully curated flight deals from Knoxville to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2026.
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/202:55 pm
TYS
- STL
2 stops8h 25m
Southwest
Tue 5/262:30 pm
STL
- TYS
1 stop4h 10m
Southwest
Deal found 4/27![Southwest logo]()
$254
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:30 am
TYS
- STL
1 stop6h 41m
United Airlines
Mon 6/15:41 pm
STL
- TYS
1 stop5h 49m
United Airlines
Deal found 4/27![United Airlines logo]()
$277
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:40 am
TYS
- MCI
1 stop4h 49m
Delta
Tue 5/266:38 pm
MCI
- TYS
1 stop4h 18m
Delta
Deal found 4/30![Delta logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/234:45 pm
TYS
- SGF
1 stop20h 19m
Allegiant Air
Sat 6/276:23 pm
SGF
- TYS
1 stop27h 24m
Allegiant Air
Deal found 4/29![Allegiant Air logo]()
$375
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:09 pm
TYS
- SGF
1 stop7h 07m
American Airlines
Mon 5/116:24 pm
SGF
- TYS
1 stop4h 31m
American Airlines
Deal found 5/1![American Airlines logo]()
$399
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:50 pm
TYS
- STL
1 stop5h 10m
Southwest
Sat 5/306:20 am
STL
- TYS
1 stop6h 00m
Southwest
Deal found 4/27![Southwest logo]()
$263
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:55 pm
TYS
- STL
1 stop5h 05m
Southwest
Tue 7/71:10 pm
STL
- TYS
1 stop7h 05m
Southwest
Deal found 4/30![Southwest logo]()
$274
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:45 pm
TYS
- STL
1 stop5h 10m
Southwest
Mon 6/12:10 pm
STL
- TYS
1 stop5h 10m
Southwest
Deal found 4/27![Southwest logo]()
$277
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:45 pm
TYS
- STL
1 stop4h 00m
Southwest
Fri 6/265:35 pm
STL
- TYS
1 stop2h 35m
Southwest
Deal found 5/1![Southwest logo]()
$294
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:27 am
TYS
- SGF
1 stop5h 00m
Delta
Mon 5/116:52 pm
SGF
- TYS
1 stop4h 04m
Delta
Deal found 4/27![Delta logo]()
$399
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:09 pm
TYS
- SGF
1 stop6h 26m
American Airlines
Sat 5/165:47 pm
SGF
- TYS
1 stop5h 09m
American Airlines
Deal found 4/28![American Airlines logo]()
$425
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:55 pm
TYS
- MCI
1 stop5h 30m
Southwest
Tue 6/302:30 pm
MCI
- TYS
1 stop4h 50m
Southwest
Deal found 4/30![Southwest logo]()
$295
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/184:20 pm
TYS
- STL
1 stop8h 35m
Southwest
Sun 6/218:25 am
STL
- TYS
1 stop7h 45m
Southwest
Deal found 4/27![Southwest logo]()
$299
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:05 pm
TYS
- JLN
1 stop7h 49m
United Airlines
Wed 10/288:52 am
JLN
- TYS
1 stop6h 57m
United Airlines
Deal found 4/27![United Airlines logo]()
$498
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/114:20 pm
TYS
- STL
1 stop8h 35m
Southwest
Sun 6/1411:45 am
STL
- TYS
1 stop8h 30m
Southwest
Deal found 5/1![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:50 pm
TYS
- MCI
1 stop5h 50m
Southwest
Tue 6/210:25 am
MCI
- TYS
2 stops8h 15m
Southwest
Deal found 4/27![Southwest logo]()
$308
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:10 am
TYS
- STL
2 stops6h 55m
Southwest
Fri 8/77:40 am
STL
- TYS
2 stops9h 55m
Southwest
Deal found 4/30![Southwest logo]()
$309
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/89:50 am
TYS
- SGF
2 stops13h 12m
United Airlines
Mon 5/1111:23 am
SGF
- TYS
2 stops11h 21m
United Airlines
Deal found 5/1![United Airlines logo]()
$610
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:45 am
TYS
- SGF
2 stops13h 21m
United Airlines
Sat 6/276:00 am
SGF
- TYS
2 stops7h 27m
United Airlines
Deal found 4/29![United Airlines logo]()
$646
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:45 pm
TYS
- MCI
1 stop5h 25m
Southwest
Tue 7/1411:50 am
MCI
- TYS
2 stops7h 30m
Southwest
Deal found 4/28![Southwest logo]()
$357
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/139:50 am
TYS
- SGF
2 stops13h 12m
United Airlines
Sun 5/176:22 pm
SGF
- TYS
1 stop25h 23m
United Airlines
Deal found 4/27![United Airlines logo]()
$677
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:40 am
TYS
- MCI
2 stops8h 05m
Southwest
Sun 6/79:00 am
MCI
- TYS
2 stops11h 15m
Southwest
Deal found 4/29![Southwest logo]()
$393
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:55 pm
TYS
- JLN
1 stop20h 27m
United Airlines
Sun 8/91:57 pm
JLN
- TYS
2 stops23h 30m
United Airlines
Deal found 4/27![United Airlines logo]()
$765
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:45 pm
TYS
- MCI
1 stop5h 50m
Southwest
Sun 5/247:05 am
MCI
- TYS
1 stop7h 40m
Southwest
Deal found 4/26![Southwest logo]()
$406
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:05 am
TYS
- MCI
2 stops8h 05m
Southwest
Sat 5/165:20 am
MCI
- TYS
2 stops10h 35m
Southwest
Deal found 4/29![Southwest logo]()
$463
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:45 pm
TYS
- MCI
2 stops5h 10m
Southwest
Tue 5/1910:25 am
MCI
- TYS
2 stops8h 15m
Southwest
Deal found 5/1![Southwest logo]()
$467
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:40 am
TYS
- MCI
2 stops8h 05m
Southwest
Thu 6/112:10 pm
MCI
- TYS
2 stops7h 20m
Southwest
Deal found 4/30![Southwest logo]()
$467
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:35 am
TYS
- MCI
2 stops7h 40m
Southwest
Mon 5/2512:05 pm
MCI
- TYS
2 stops7h 15m
Southwest
Deal found 4/26![Southwest logo]()
$487
Last-minute flights from Knoxville to MissouriDiscover last-minute flight deals from Knoxville to Missouri. Data last updated May 1, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Missouri. Data last updated May 1, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- STL
1 stop12h 06m
Multiple Airlines
Mon 5/255:27 pm
STL
- TYS
2 stops21h 48m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$275
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:15 am
TYS
- STL
1 stop8h 00m
Southwest
Tue 5/265:45 am
STL
- TYS
1 stop7h 35m
Southwest
Deal found 4/27![Southwest logo]()
$249
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:40 am
TYS
- MCI
1 stop4h 49m
Delta
Tue 5/268:05 am
MCI
- TYS
1 stop4h 05m
Delta
Deal found 4/27![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:50 pm
TYS
- STL
1 stop5h 10m
Southwest
Sat 5/306:20 am
STL
- TYS
1 stop6h 00m
Southwest
Deal found 4/27![Southwest logo]()
$263
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:33 pm
TYS
- MCI
1 stop7h 53m
American Airlines
Tue 6/25:16 pm
MCI
- TYS
1 stop5h 31m
American Airlines
Deal found 4/27![American Airlines logo]()
$295
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:50 pm
TYS
- MCI
1 stop5h 50m
Southwest
Tue 6/210:25 am
MCI
- TYS
2 stops8h 15m
Southwest
Deal found 4/27![Southwest logo]()
$308
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:50 pm
TYS
- STL
2 stops7h 25m
Southwest
Thu 6/412:40 pm
STL
- TYS
2 stops8h 50m
Southwest
Deal found 4/30![Southwest logo]()
$281
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:45 pm
TYS
- STL
1 stop5h 10m
Southwest
Mon 6/12:10 pm
STL
- TYS
1 stop5h 10m
Southwest
Deal found 4/27![Southwest logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:27 pm
TYS
- SGF
1 stop13h 42m
Allegiant Air
Thu 6/48:20 pm
SGF
- TYS
1 stop20h 29m
Allegiant Air
Deal found 4/30![Allegiant Air logo]()
$301
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:00 am
TYS
- MCI
1 stop7h 26m
American Airlines
Mon 6/15:16 pm
MCI
- TYS
1 stop5h 31m
American Airlines
Deal found 4/30![American Airlines logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2912:55 pm
TYS
- STL
2 stops21h 00m
Multiple Airlines
Tue 6/24:19 pm
STL
- TYS
1 stop25h 02m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$243
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:45 pm
TYS
- STL
1 stop3h 10m
Southwest
Tue 6/22:30 pm
STL
- TYS
1 stop4h 10m
Southwest
Deal found 4/27![Southwest logo]()
$274
One-way flights from Knoxville to MissouriSearch for one-way flight options from Knoxville to Missouri. Find affordable one-way fares based on user searches. Data last updated May 1, 2026.
Search for one-way flight options from Knoxville to Missouri. Find affordable one-way fares based on user searches. Data last updated May 1, 2026.
This Trip.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:32 pm
TYS
- STL
1 stop23h 51m
Frontier
Deal found 4/29![Frontier logo]()
$98
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:50 pm
TYS
- STL
1 stop5h 10m
Southwest
Deal found 4/28![Southwest logo]()
$125
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:12 am
TYS
- STL
1 stop5h 25m
American Airlines
Deal found 4/28![American Airlines logo]()
$139
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:35 am
TYS
- STL
2 stops6h 55m
Southwest
Deal found 4/28![Southwest logo]()
$144
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:33 pm
TYS
- MCI
1 stop7h 53m
American Airlines
Deal found 4/27![American Airlines logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:46 pm
TYS
- MCI
1 stop17h 36m
Allegiant Air
Deal found 4/29![Allegiant Air logo]()
$149
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:12 am
TYS
- STL
1 stop5h 25m
American Airlines
Deal found 4/30![American Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:46 pm
TYS
- STL
3 stops50h 47m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$151
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/57:00 am
TYS
- STL
2 stops6h 40m
Southwest
Deal found 4/28![Southwest logo]()
$155
This Trip.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/99:00 am
TYS
- MCI
1 stop23h 54m
Allegiant Air
Deal found 4/29![Allegiant Air logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:15 pm
TYS
- STL
2 stops29h 49m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:45 am
TYS
- MCI
2 stops11h 44m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$161
Find flight deals from Knoxville to Missouri
Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated May 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $243 (Kiwi.com) |
One-way from | $98 (Trip.com) |
Popular in | November |
Cheapest in | May |
Average price | $293 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Wed 5/20
2:55 pm-10:20 pm
2 stops8h 25m
Lambert-St Louis
Tue 5/26
2:30 pm-7:40 pm
1 stop4h 10m
$254
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Tue 5/26
5:50 pm-10:00 pm
1 stop5h 10m
Lambert-St Louis
Sat 5/30
6:20 am-1:20 pm
1 stop6h 00m
$263
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Wed 7/1
6:55 pm-11:00 pm
1 stop5h 05m
Lambert-St Louis
Tue 7/7
1:10 pm-9:15 pm
1 stop7h 05m
$274
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Thu 5/28
6:30 am-12:11 pm
1 stop6h 41m
Lambert-St Louis
Mon 6/1
5:41 pm-12:30 am
1 stop5h 49m
$277
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Thu 5/28
2:45 pm-6:55 pm
1 stop5h 10m
Lambert-St Louis
Mon 6/1
2:10 pm-8:20 pm
1 stop5h 10m
$277
Quickest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Fri 6/19
7:45 pm-10:45 pm
1 stop4h 00m
Lambert-St Louis
Fri 6/26
5:35 pm-9:10 pm
1 stop2h 35m
$294
KnoxvilleKansas City
TYS - MCI
TYSMCI
Knoxville McGhee Tyson
Tue 6/16
6:55 pm-11:25 pm
1 stop5h 30m
Kansas City
Tue 6/30
2:30 pm-8:20 pm
1 stop4h 50m
$295
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Thu 6/18
4:20 pm-11:55 pm
1 stop8h 35m
Lambert-St Louis
Sun 6/21
8:25 am-5:10 pm
1 stop7h 45m
$299
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Thu 6/11
4:20 pm-11:55 pm
1 stop8h 35m
Lambert-St Louis
Sun 6/14
11:45 am-9:15 pm
1 stop8h 30m
$304
KnoxvilleKansas City
TYS - MCI
TYSMCI
Knoxville McGhee Tyson
Tue 5/26
5:50 pm-10:40 pm
1 stop5h 50m
Kansas City
Tue 6/2
10:25 am-7:40 pm
2 stops8h 15m
$308
Showing 1-10 of 48 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
TYS-STL
TYS-MCI
TYS-SGF
TYS-JLN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Missouri
TYS-USMO
TYS-STL
TYS-MCI
TYS-SGF
TYS-JLN
What is the cheapest month to book a flight from Knoxville to Missouri?
Currently, September is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $150). Flying from Knoxville to Missouri in June is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated May 1, 2026.
See what other customers who have flown with Delta and American Airlines from Knoxville to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Entertainment
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Knoxville and Missouri flights
Browse other Knoxville and Missouri flight options. Last updated on May 1, 2026.
Popular flight searches
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Knoxville to Missouri flights
Consider these flights traveling from Knoxville to Missouri.
Top 2 airlines flying from Knoxville to Missouri
Discover the top 2 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$373 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$228 | Average$340 | FlexibilityNo cancel fee | On-timeN/A |