$112+ Cheap flights from Knoxville (TYS) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MCI
Jul 20 — Jul 271
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to MissouriExplore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 20, 2026.
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 20, 2026.
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:40 pm
TYS
- STL
1 stop7h 15m
Southwest
Wed 7/151:45 pm
STL
- TYS
1 stop5h 40m
Southwest
Deal found 6/16![Southwest logo]()
$237
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:10 am
TYS
- STL
1 stop4h 00m
Southwest
Wed 9/167:05 am
STL
- TYS
1 stop6h 15m
Southwest
Deal found 6/18![Southwest logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1312:53 pm
TYS
- STL
2 stops29h 44m
Multiple Airlines
Mon 7/204:09 pm
STL
- TYS
1 stop6h 24m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$263
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:31 pm
TYS
- STL
1 stop7h 33m
American Airlines
Tue 7/215:10 am
STL
- TYS
1 stop6h 24m
American Airlines
Deal found 6/16![American Airlines logo]()
$268
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:10 am
TYS
- STL
2 stops6h 55m
Southwest
Fri 7/315:35 pm
STL
- TYS
1 stop2h 40m
Southwest
Deal found 6/18![Southwest logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1012:40 pm
TYS
- STL
2 stops21h 17m
Multiple Airlines
Tue 7/148:08 pm
STL
- TYS
1 stop22h 16m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:30 am
TYS
- SGF
1 stop24h 03m
Allegiant Air
Fri 8/2810:23 am
SGF
- TYS
1 stop6h 14m
Allegiant Air
Deal found 6/20![Allegiant Air logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/44:20 pm
TYS
- SGF
1 stop21h 53m
Allegiant Air
Fri 8/77:55 pm
SGF
- TYS
1 stop19h 40m
Allegiant Air
Deal found 6/20![Allegiant Air logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/44:20 pm
TYS
- SGF
1 stop21h 53m
Allegiant Air
Sat 8/84:05 pm
SGF
- TYS
1 stop19h 26m
Allegiant Air
Deal found 6/20![Allegiant Air logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/44:20 pm
TYS
- SGF
1 stop21h 53m
Allegiant Air
Thu 8/68:04 pm
SGF
- TYS
1 stop15h 47m
Allegiant Air
Deal found 6/20![Allegiant Air logo]()
$288
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:29 pm
TYS
- MCI
2 stops23h 41m
Multiple Airlines
Mon 8/1010:40 am
MCI
- TYS
1 stop11h 51m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/68:15 am
TYS
- SGF
1 stop11h 59m
Allegiant Air
Sat 8/84:05 pm
SGF
- TYS
1 stop19h 26m
Allegiant Air
Deal found 6/20![Allegiant Air logo]()
$298
Best flights from Knoxville to MissouriDiscover carefully curated flight deals from Knoxville to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 20, 2026.
Discover carefully curated flight deals from Knoxville to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 20, 2026.
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/51:55 pm
TYS
- STL
1 stop5h 00m
Southwest
Wed 8/128:35 am
STL
- TYS
1 stop4h 45m
Southwest
Deal found 6/16![Southwest logo]()
$237
This United Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:02 pm
TYS
- STL
1 stop4h 58m
United Airlines
Wed 9/28:50 am
STL
- TYS
1 stop7h 08m
United Airlines
Deal found 6/19![United Airlines logo]()
$307
This Delta deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:40 am
TYS
- STL
1 stop3h 39m
Delta
Tue 7/141:22 pm
STL
- TYS
1 stop5h 50m
Delta
Deal found 6/18![Delta logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/258:40 pm
TYS
- MCI
2 stops45h 30m
Multiple Airlines
Sun 8/24:32 pm
MCI
- TYS
1 stop20h 25m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$323
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:13 pm
TYS
- SGF
1 stop6h 56m
American Airlines
Sat 7/47:00 am
SGF
- TYS
1 stop5h 06m
American Airlines
Deal found 6/16![American Airlines logo]()
$324
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:30 am
TYS
- SGF
2 stops34h 59m
Allegiant Air
Fri 7/248:02 pm
SGF
- TYS
1 stop11h 08m
Allegiant Air
Deal found 6/18![Allegiant Air logo]()
$437
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:40 pm
TYS
- STL
1 stop7h 15m
Southwest
Wed 7/221:45 pm
STL
- TYS
1 stop5h 40m
Southwest
Deal found 6/17![Southwest logo]()
$237
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:10 am
TYS
- STL
1 stop4h 00m
Southwest
Wed 9/167:05 am
STL
- TYS
1 stop6h 15m
Southwest
Deal found 6/18![Southwest logo]()
$248
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:00 am
TYS
- MCI
1 stop5h 29m
United Airlines
Tue 8/46:00 am
MCI
- TYS
2 stops7h 27m
United Airlines
Deal found 6/16![United Airlines logo]()
$323
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:37 am
TYS
- MCI
1 stop5h 57m
American Airlines
Sun 7/195:31 am
MCI
- TYS
1 stop6h 25m
American Airlines
Deal found 6/17![American Airlines logo]()
$357
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:55 pm
TYS
- STL
1 stop5h 10m
Southwest
Thu 7/169:25 am
STL
- TYS
1 stop8h 45m
Southwest
Deal found 6/17![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:45 am
TYS
- MCI
2 stops11h 15m
United Airlines
Tue 7/145:45 pm
MCI
- TYS
1 stop5h 09m
United Airlines
Deal found 6/17![United Airlines logo]()
$364
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:55 pm
TYS
- MCI
2 stops5h 35m
Southwest
Mon 7/273:00 pm
MCI
- TYS
1 stop5h 15m
Southwest
Deal found 6/17![Southwest logo]()
$323
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:45 am
TYS
- JLN
2 stops8h 37m
United Airlines
Sun 7/58:54 am
JLN
- TYS
1 stop7h 06m
United Airlines
Deal found 6/17![United Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:04 pm
TYS
- SGF
1 stop13h 47m
Allegiant Air
Sun 7/57:45 pm
SGF
- TYS
1 stop26h 34m
Allegiant Air
Deal found 6/17![Allegiant Air logo]()
$460
This United Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:45 am
TYS
- JLN
2 stops8h 37m
United Airlines
Tue 7/78:54 am
JLN
- TYS
1 stop7h 06m
United Airlines
Deal found 6/19![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:43 pm
TYS
- SGF
1 stop4h 57m
American Airlines
Sun 7/57:00 am
SGF
- TYS
1 stop4h 56m
American Airlines
Deal found 6/16![American Airlines logo]()
$478
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/104:20 pm
TYS
- STL
1 stop7h 25m
Southwest
Mon 7/135:35 pm
STL
- TYS
1 stop2h 40m
Southwest
Deal found 6/18![Southwest logo]()
$372
This United Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:00 am
TYS
- JLN
1 stop6h 22m
United Airlines
Wed 11/41:20 pm
JLN
- TYS
1 stop8h 18m
United Airlines
Deal found 6/19![United Airlines logo]()
$384
This United Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:00 am
TYS
- SGF
1 stop4h 48m
United Airlines
Sat 8/291:37 pm
SGF
- TYS
1 stop7h 52m
United Airlines
Deal found 6/19![United Airlines logo]()
$389
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:55 pm
TYS
- MCI
2 stops5h 35m
Southwest
Tue 7/1412:25 pm
MCI
- TYS
2 stops7h 00m
Southwest
Deal found 6/20![Southwest logo]()
$427
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:55 pm
TYS
- MCI
2 stops5h 35m
Southwest
Sun 7/125:05 am
MCI
- TYS
2 stops6h 00m
Southwest
Deal found 6/17![Southwest logo]()
$428
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:10 am
TYS
- MCI
2 stops7h 20m
Southwest
Thu 9/108:20 am
MCI
- TYS
2 stops9h 15m
Southwest
Deal found 6/17![Southwest logo]()
$457
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:59 pm
TYS
- JLN
1 stop5h 47m
United Airlines
Fri 8/288:30 am
JLN
- TYS
1 stop7h 28m
United Airlines
Deal found 6/20![United Airlines logo]()
$532
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/251:35 pm
TYS
- MCI
1 stop9h 40m
Southwest
Sun 8/22:30 pm
MCI
- TYS
2 stops5h 50m
Southwest
Deal found 6/20![Southwest logo]()
$458
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:45 pm
TYS
- JLN
1 stop20h 37m
United Airlines
Tue 7/78:54 am
JLN
- TYS
1 stop7h 06m
United Airlines
Deal found 6/17![United Airlines logo]()
$564
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:40 am
TYS
- MCI
2 stops7h 50m
Southwest
Sun 7/57:25 am
MCI
- TYS
1 stop9h 55m
Southwest
Deal found 6/15![Southwest logo]()
$488
Last-minute flights from Knoxville to MissouriDiscover last-minute flight deals from Knoxville to Missouri. Data last updated June 20, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Missouri. Data last updated June 20, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:13 pm
TYS
- SGF
1 stop6h 56m
American Airlines
Sat 7/47:00 am
SGF
- TYS
1 stop5h 06m
American Airlines
Deal found 6/16![American Airlines logo]()
$324
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:55 pm
TYS
- STL
1 stop5h 10m
Southwest
Fri 7/105:35 pm
STL
- TYS
1 stop2h 40m
Southwest
Deal found 6/17![Southwest logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1012:40 pm
TYS
- STL
2 stops21h 17m
Multiple Airlines
Tue 7/148:08 pm
STL
- TYS
1 stop22h 16m
Multiple Airlines
Deal found 6/18![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1312:53 pm
TYS
- STL
2 stops29h 44m
Multiple Airlines
Mon 7/204:09 pm
STL
- TYS
1 stop6h 24m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$263
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:40 pm
TYS
- STL
1 stop7h 15m
Southwest
Wed 7/151:45 pm
STL
- TYS
1 stop5h 40m
Southwest
Deal found 6/16![Southwest logo]()
$237
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/148:11 pm
TYS
- MCI
1 stop5h 12m
American Airlines
Thu 7/235:31 am
MCI
- TYS
1 stop6h 22m
American Airlines
Deal found 6/16![American Airlines logo]()
$318
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:31 pm
TYS
- STL
1 stop7h 33m
American Airlines
Tue 7/215:10 am
STL
- TYS
1 stop6h 24m
American Airlines
Deal found 6/16![American Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:20 pm
TYS
- MCI
2 stops18h 40m
Multiple Airlines
Thu 7/236:57 pm
MCI
- TYS
1 stop27h 22m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:55 pm
TYS
- MCI
2 stops5h 35m
Southwest
Mon 7/273:00 pm
MCI
- TYS
1 stop5h 15m
Southwest
Deal found 6/17![Southwest logo]()
$323
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:45 pm
TYS
- STL
1 stop4h 05m
Southwest
Sat 7/2512:50 pm
STL
- TYS
1 stop5h 50m
Southwest
Deal found 6/18![Southwest logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/262:08 pm
TYS
- MCI
1 stop25h 05m
Multiple Airlines
Sat 8/16:07 pm
MCI
- TYS
2 stops25h 14m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$311
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:10 am
TYS
- STL
2 stops6h 55m
Southwest
Fri 7/315:35 pm
STL
- TYS
1 stop2h 40m
Southwest
Deal found 6/18![Southwest logo]()
$269
One-way flights from Knoxville to MissouriSearch for one-way flight options from Knoxville to Missouri. Find affordable one-way fares based on user searches. Data last updated June 20, 2026.
Search for one-way flight options from Knoxville to Missouri. Find affordable one-way fares based on user searches. Data last updated June 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:40 pm
TYS
- STL
2 stops29h 57m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$112
This United Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:00 am
TYS
- STL
1 stop7h 11m
United Airlines
Deal found 6/19![United Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1712:40 pm
TYS
- MCI
2 stops29h 30m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$122
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/217:10 am
TYS
- STL
2 stops6h 55m
Southwest
Deal found 6/19![Southwest logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/131:19 pm
TYS
- STL
2 stops21h 21m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$128
This Trip.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/208:19 pm
TYS
- MCI
1 stop17h 41m
Frontier
Deal found 6/20![Frontier logo]()
$136
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:02 pm
TYS
- MCI
1 stop4h 42m
United Airlines
Deal found 6/17![United Airlines logo]()
$140
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:00 am
TYS
- MCI
2 stops8h 25m
Southwest
Deal found 6/17![Southwest logo]()
$145
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/181:35 pm
TYS
- STL
1 stop4h 50m
Southwest
Deal found 6/18![Southwest logo]()
$150
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:45 pm
TYS
- STL
1 stop4h 41m
United Airlines
Deal found 6/20![United Airlines logo]()
$154
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:02 pm
TYS
- MCI
1 stop4h 42m
United Airlines
Deal found 6/16![United Airlines logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:30 am
TYS
- MCI
2 stops31h 30m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$162
Find flight deals from Knoxville to Missouri
Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated June 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $237 (Southwest) |
One-way from | $112 (Kiwi.com) |
Popular in | November |
Cheapest in | January |
Average price | $300 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 20, 2026.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Wed 8/5
1:55 pm-5:55 pm
1 stop5h 00m
Lambert-St Louis
Wed 8/12
8:35 am-2:20 pm
1 stop4h 45m
$237
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Wed 7/15
5:40 pm-11:55 pm
1 stop7h 15m
Lambert-St Louis
Wed 7/22
1:45 pm-8:25 pm
1 stop5h 40m
$237
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Mon 9/14
7:10 am-10:10 am
1 stop4h 00m
Lambert-St Louis
Wed 9/16
7:05 am-2:20 pm
1 stop6h 15m
$248
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Tue 9/1
6:02 pm-10:00 pm
1 stop4h 58m
Lambert-St Louis
Wed 9/2
8:50 am-4:58 pm
1 stop7h 08m
$307
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Wed 7/15
6:55 pm-11:05 pm
1 stop5h 10m
Lambert-St Louis
Thu 7/16
9:25 am-7:10 pm
1 stop8h 45m
$307
Quickest round-trip
KnoxvilleSt. Louis
TYS - STL
TYSSTL
Knoxville McGhee Tyson
Fri 7/10
5:40 am-8:19 am
1 stop3h 39m
Lambert-St Louis
Tue 7/14
1:22 pm-8:12 pm
1 stop5h 50m
$315
KnoxvilleKansas City
TYS - MCI
TYSMCI
Knoxville McGhee Tyson
Sat 7/25
8:40 pm-5:10 pm
2 stops45h 30m
Kansas City
Sun 8/2
4:32 pm-1:57 pm
1 stop20h 25m
$323
KnoxvilleKansas City
TYS - MCI
TYSMCI
Knoxville McGhee Tyson
Sat 8/1
6:00 am-10:29 am
1 stop5h 29m
Kansas City
Tue 8/4
6:00 am-2:27 pm
2 stops7h 27m
$323
KnoxvilleKansas City
TYS - MCI
TYSMCI
Knoxville McGhee Tyson
Tue 7/21
6:55 pm-11:30 pm
2 stops5h 35m
Kansas City
Mon 7/27
3:00 pm-9:15 pm
1 stop5h 15m
$323
KnoxvilleSpringfield
TYS - SGF
TYSSGF
Knoxville McGhee Tyson
Tue 6/30
1:13 pm-7:09 pm
1 stop6h 56m
Springfield-Branson
Sat 7/4
7:00 am-1:06 pm
1 stop5h 06m
$324
Showing 1-10 of 53 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
TYS-STL
TYS-MCI
TYS-SGF
TYS-JLN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Missouri
TYS-USMO
TYS-STL
TYS-MCI
TYS-SGF
TYS-JLN
What is the cheapest month to book a flight from Knoxville to Missouri?
Currently, September is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $150). Flying from Knoxville to Missouri in June is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated June 20, 2026.
See what other customers who have flown with Southwest,Delta, andAmerican Airlines from Knoxville to Missouri have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Crew
8.6
Overall
7.9
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Food
7.0
Boarding
8.1
Crew
8.6
Overall
7.9
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Food
7.0
Boarding
8.1
Crew
8.6
Overall
7.9
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Food
7.0
Boarding
8.1
Crew
8.6
Overall
7.9
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to Missouri
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Knoxville and Missouri flights
Browse other Knoxville and Missouri flight options. Last updated on June 20, 2026.
Popular flight searches
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Knoxville to Missouri flights
Consider these flights traveling from Knoxville to Missouri.
Top 3 airlines flying from Knoxville to Missouri
Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$362 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$367 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$248 | Average$339 | FlexibilityNo cancel fee | On-timeN/A |