$100+ Cheap flights from Missouri to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — TYS
Jul 17 — Jul 241
Round-trip
1 adult, Economy
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Cheapest flights from Missouri to KnoxvilleExplore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 17, 2026.
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:44 am
COU
- TYS
1 stop28h 52m
Allegiant Air
Sun 8/162:12 pm
TYS
- COU
1 stop19h 54m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:44 am
COU
- TYS
1 stop26h 22m
Allegiant Air
Fri 8/149:08 pm
TYS
- COU
1 stop14h 31m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2410:34 am
COU
- TYS
1 stop6h 03m
Allegiant Air
Thu 8/271:21 pm
TYS
- COU
1 stop20h 48m
Allegiant Air
Deal found 6/15![Allegiant Air logo]()
$233
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:31 am
STL
- TYS
1 stop6h 49m
American Airlines
Wed 7/155:00 am
TYS
- STL
1 stop4h 33m
American Airlines
Deal found 6/13![American Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:20 am
STL
- TYS
1 stop5h 40m
Southwest
Wed 7/157:10 am
TYS
- STL
2 stops6h 55m
Southwest
Deal found 6/13![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:20 am
STL
- TYS
2 stops8h 05m
Southwest
Tue 7/217:10 am
TYS
- STL
2 stops6h 55m
Southwest
Deal found 6/16![Southwest logo]()
$247
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:15 am
STL
- TYS
1 stop3h 50m
Southwest
Thu 8/272:05 pm
TYS
- STL
1 stop4h 50m
Southwest
Deal found 6/14![Southwest logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/811:44 am
COU
- TYS
1 stop5h 41m
Allegiant Air
Tue 7/144:20 pm
TYS
- COU
1 stop19h 34m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$257
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:25 am
STL
- TYS
1 stop8h 30m
Southwest
Mon 8/312:05 pm
TYS
- STL
1 stop6h 15m
Southwest
Deal found 6/15![Southwest logo]()
$259
This Frontier deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/61:45 pm
MCI
- TYS
1 stop28h 39m
Frontier
Mon 8/108:19 pm
TYS
- MCI
1 stop17h 41m
Frontier
Deal found 6/12![Frontier logo]()
$263
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2910:20 am
STL
- TYS
1 stop5h 40m
Southwest
Mon 8/34:20 pm
TYS
- STL
1 stop8h 35m
Southwest
Deal found 6/16![Southwest logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/811:29 am
COU
- TYS
1 stop9h 34m
Allegiant Air
Sun 8/162:12 pm
TYS
- COU
1 stop19h 54m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$271
Best flights from Missouri to KnoxvilleDiscover carefully curated flight deals from Missouri to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 17, 2026.
Discover carefully curated flight deals from Missouri to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 17, 2026.
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:58 pm
STL
- TYS
1 stop4h 37m
Delta
Wed 7/155:40 am
TYS
- STL
1 stop5h 03m
Delta
Deal found 6/13![Delta logo]()
$253
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:50 am
STL
- TYS
1 stop7h 15m
Southwest
Fri 7/317:45 pm
TYS
- STL
1 stop4h 05m
Southwest
Deal found 6/16![Southwest logo]()
$268
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/13:25 pm
COU
- TYS
1 stop4h 19m
United Airlines
Thu 8/66:00 am
TYS
- COU
1 stop5h 13m
United Airlines
Deal found 6/14![United Airlines logo]()
$278
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:31 am
MCI
- TYS
1 stop6h 35m
American Airlines
Tue 7/75:37 am
TYS
- MCI
1 stop5h 57m
American Airlines
Deal found 6/13![American Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1010:40 am
MCI
- TYS
1 stop11h 39m
Multiple Airlines
Mon 7/136:30 am
TYS
- MCI
2 stops31h 30m
Multiple Airlines
Deal found 6/12![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/811:44 am
COU
- TYS
2 stops48h 02m
Allegiant Air
Tue 7/144:20 pm
TYS
- COU
1 stop19h 34m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$325
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/291:45 pm
STL
- TYS
1 stop5h 40m
Southwest
Sun 8/27:00 pm
TYS
- STL
1 stop5h 55m
Southwest
Deal found 6/15![Southwest logo]()
$268
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:58 pm
STL
- TYS
1 stop4h 37m
Delta
Mon 7/135:40 am
TYS
- STL
1 stop3h 39m
Delta
Deal found 6/13![Delta logo]()
$282
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2210:20 am
STL
- TYS
1 stop5h 40m
Southwest
Mon 7/277:45 pm
TYS
- STL
1 stop4h 05m
Southwest
Deal found 6/14![Southwest logo]()
$268
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/11:18 pm
STL
- TYS
1 stop6h 26m
United Airlines
Fri 8/76:00 am
TYS
- STL
1 stop5h 34m
United Airlines
Deal found 6/12![United Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:57 pm
SGF
- TYS
1 stop6h 55m
American Airlines
Wed 11/115:10 am
TYS
- SGF
1 stop5h 48m
American Airlines
Deal found 6/12![American Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/611:05 am
STL
- TYS
2 stops7h 50m
Southwest
Mon 8/107:10 am
TYS
- STL
2 stops6h 55m
Southwest
Deal found 6/14![Southwest logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:21 pm
SGF
- TYS
1 stop14h 41m
Allegiant Air
Mon 9/287:04 pm
TYS
- SGF
1 stop15h 54m
Allegiant Air
Deal found 6/15![Allegiant Air logo]()
$368
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2912:40 pm
STL
- TYS
2 stops6h 45m
Southwest
Mon 8/36:40 am
TYS
- STL
2 stops9h 05m
Southwest
Deal found 6/16![Southwest logo]()
$278
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:00 am
MCI
- TYS
2 stops7h 37m
United Airlines
Wed 9/27:00 am
TYS
- MCI
1 stop4h 25m
United Airlines
Deal found 6/11![United Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/113:59 pm
SGF
- TYS
1 stop6h 52m
American Airlines
Sat 7/185:37 am
TYS
- SGF
1 stop5h 35m
American Airlines
Deal found 6/12![American Airlines logo]()
$368
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:10 am
STL
- TYS
2 stops7h 25m
Southwest
Tue 9/85:30 pm
TYS
- STL
1 stop5h 40m
Southwest
Deal found 6/15![Southwest logo]()
$283
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/83:25 pm
COU
- TYS
1 stop4h 19m
United Airlines
Thu 8/135:45 am
TYS
- COU
2 stops9h 45m
United Airlines
Deal found 6/13![United Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/159:30 am
MCI
- TYS
1 stop6h 30m
Southwest
Wed 7/226:55 pm
TYS
- MCI
2 stops5h 35m
Southwest
Deal found 6/16![Southwest logo]()
$284
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3010:49 am
COU
- TYS
1 stop5h 11m
United Airlines
Sat 7/45:45 am
TYS
- COU
2 stops10h 05m
United Airlines
Deal found 6/15![United Airlines logo]()
$376
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:35 pm
STL
- TYS
1 stop2h 40m
Southwest
Mon 8/37:30 am
TYS
- STL
2 stops7h 50m
Southwest
Deal found 6/14![Southwest logo]()
$300
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/101:32 pm
MCI
- TYS
1 stop7h 47m
United Airlines
Wed 8/124:50 pm
TYS
- MCI
1 stop7h 40m
United Airlines
Deal found 6/15![United Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:03 pm
SGF
- TYS
1 stop4h 50m
United Airlines
Wed 9/27:15 am
TYS
- SGF
1 stop8h 01m
United Airlines
Deal found 6/15![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am
SGF
- TYS
1 stop6h 06m
American Airlines
Wed 10/146:00 am
TYS
- SGF
1 stop6h 02m
American Airlines
Deal found 6/11![American Airlines logo]()
$549
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/68:20 am
MCI
- TYS
1 stop7h 50m
Southwest
Mon 8/107:10 am
TYS
- MCI
2 stops8h 05m
Southwest
Deal found 6/14![Southwest logo]()
$351
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1910:48 am
COU
- TYS
2 stops8h 46m
United Airlines
Wed 6/246:00 am
TYS
- COU
1 stop5h 13m
United Airlines
Deal found 6/15![United Airlines logo]()
$434
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:10 am
MCI
- TYS
2 stops9h 30m
Southwest
Thu 8/135:45 pm
TYS
- MCI
2 stops6h 30m
Southwest
Deal found 6/15![Southwest logo]()
$366
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:49 am
COU
- TYS
2 stops12h 05m
United Airlines
Sat 8/157:00 am
TYS
- COU
1 stop4h 16m
United Airlines
Deal found 6/13![United Airlines logo]()
$444
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/810:49 am
COU
- TYS
2 stops12h 05m
United Airlines
Tue 8/117:00 am
TYS
- COU
1 stop4h 16m
United Airlines
Deal found 6/13![United Airlines logo]()
$444
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/810:49 am
COU
- TYS
2 stops12h 05m
United Airlines
Wed 8/127:00 am
TYS
- COU
1 stop4h 16m
United Airlines
Deal found 6/13![United Airlines logo]()
$444
Last-minute flights from Missouri to KnoxvilleDiscover last-minute flight deals from Missouri to Knoxville. Data last updated June 17, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Knoxville. Data last updated June 17, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:58 pm
STL
- TYS
1 stop4h 37m
Delta
Wed 7/155:40 am
TYS
- STL
1 stop5h 03m
Delta
Deal found 6/13![Delta logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:09 pm
STL
- TYS
1 stop25h 16m
Multiple Airlines
Mon 7/1312:53 pm
TYS
- STL
2 stops29h 44m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$272
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:58 pm
STL
- TYS
1 stop4h 37m
Delta
Mon 7/135:40 am
TYS
- STL
1 stop3h 39m
Delta
Deal found 6/13![Delta logo]()
$282
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:31 am
STL
- TYS
1 stop6h 49m
American Airlines
Wed 7/155:00 am
TYS
- STL
1 stop4h 33m
American Airlines
Deal found 6/13![American Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:20 am
STL
- TYS
1 stop5h 40m
Southwest
Wed 7/157:10 am
TYS
- STL
2 stops6h 55m
Southwest
Deal found 6/13![Southwest logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/811:44 am
COU
- TYS
1 stop5h 41m
Allegiant Air
Tue 7/144:20 pm
TYS
- COU
1 stop19h 34m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$257
This Booking.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:08 pm
STL
- TYS
1 stop22h 16m
Frontier
Mon 7/138:19 pm
TYS
- STL
1 stop24h 04m
Frontier
Deal found 6/12![Frontier logo]()
$259
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:20 am
STL
- TYS
2 stops8h 05m
Southwest
Tue 7/217:10 am
TYS
- STL
2 stops6h 55m
Southwest
Deal found 6/16![Southwest logo]()
$247
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:39 am
MCI
- TYS
1 stop5h 14m
American Airlines
Tue 7/215:37 am
TYS
- MCI
1 stop5h 57m
American Airlines
Deal found 6/16![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/159:30 am
MCI
- TYS
1 stop6h 30m
Southwest
Wed 7/226:55 pm
TYS
- MCI
2 stops5h 35m
Southwest
Deal found 6/16![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2210:20 am
STL
- TYS
1 stop5h 40m
Southwest
Mon 7/277:45 pm
TYS
- STL
1 stop4h 05m
Southwest
Deal found 6/14![Southwest logo]()
$268
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:25 am
STL
- TYS
1 stop8h 55m
Southwest
Fri 7/316:40 am
TYS
- STL
2 stops7h 05m
Southwest
Deal found 6/16![Southwest logo]()
$273
One-way flights from Missouri to KnoxvilleSearch for one-way flight options from Missouri to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 17, 2026.
Search for one-way flight options from Missouri to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 17, 2026.
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:40 am
STL
- TYS
1 stop3h 35m
Southwest
Deal found 6/11![Southwest logo]()
$100
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/148:25 am
STL
- TYS
1 stop8h 55m
Southwest
Deal found 6/14![Southwest logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:33 pm
STL
- TYS
2 stops23h 02m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/26:34 pm
STL
- TYS
2 stops26h 26m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$129
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:40 am
STL
- TYS
1 stop4h 45m
Southwest
Deal found 6/15![Southwest logo]()
$130
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:10 am
STL
- TYS
2 stops8h 50m
Southwest
Deal found 6/13![Southwest logo]()
$135
This Mytrip deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:45 pm
MCI
- TYS
1 stop28h 39m
Frontier
Deal found 6/12![Frontier logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:34 pm
STL
- TYS
2 stops26h 26m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$139
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:04 pm
MCI
- TYS
1 stop5h 47m
American Airlines
Deal found 6/12![American Airlines logo]()
$140
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:35 pm
STL
- TYS
1 stop2h 40m
Southwest
Deal found 6/11![Southwest logo]()
$145
This Trip.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/28:08 pm
STL
- TYS
1 stop22h 16m
Frontier
Deal found 6/14![Frontier logo]()
$149
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:26 am
MCI
- TYS
1 stop7h 02m
American Airlines
Deal found 6/13![American Airlines logo]()
$154
Find flight deals from Missouri to Knoxville
Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated June 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $191 (Kiwi.com) |
One-way from | $100 (Southwest) |
Popular in | June |
Cheapest in | August |
Average price | $566 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 17, 2026.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Tue 7/7
3:58 pm-9:35 pm
1 stop4h 37m
Knoxville McGhee Tyson
Wed 7/15
5:40 am-9:43 am
1 stop5h 03m
$253
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Tue 7/28
5:50 am-2:05 pm
1 stop7h 15m
Knoxville McGhee Tyson
Fri 7/31
7:45 pm-10:50 pm
1 stop4h 05m
$268
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Wed 7/29
1:45 pm-8:25 pm
1 stop5h 40m
Knoxville McGhee Tyson
Sun 8/2
7:00 pm-11:55 pm
1 stop5h 55m
$268
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Wed 7/22
10:20 am-5:00 pm
1 stop5h 40m
Knoxville McGhee Tyson
Mon 7/27
7:45 pm-10:50 pm
1 stop4h 05m
$268
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 8/6
11:05 am-7:55 pm
2 stops7h 50m
Knoxville McGhee Tyson
Mon 8/10
7:10 am-1:05 pm
2 stops6h 55m
$269
ColumbiaKnoxville
COU - TYS
COUTYS
Columbia Regional
Sat 8/1
3:25 pm-8:44 pm
1 stop4h 19m
Knoxville McGhee Tyson
Thu 8/6
6:00 am-10:13 am
1 stop5h 13m
$278
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Wed 7/29
12:40 pm-8:25 pm
2 stops6h 45m
Knoxville McGhee Tyson
Mon 8/3
6:40 am-2:45 pm
2 stops9h 05m
$278
Quickest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Tue 7/7
3:58 pm-9:35 pm
1 stop4h 37m
Knoxville McGhee Tyson
Mon 7/13
5:40 am-8:19 am
1 stop3h 39m
$282
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 9/3
10:10 am-6:35 pm
2 stops7h 25m
Knoxville McGhee Tyson
Tue 9/8
5:30 pm-10:10 pm
1 stop5h 40m
$283
Kansas CityKnoxville
MCI - TYS
MCITYS
Kansas City
Wed 7/15
9:30 am-5:00 pm
1 stop6h 30m
Knoxville McGhee Tyson
Wed 7/22
6:55 pm-11:30 pm
2 stops5h 35m
$284
Showing 1-10 of 56 resultsSorted by cheapest first
Best time to book a flight from Missouri to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
STL-TYS
SGF-TYS
COU-TYS
MCI-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Knoxville
USMO-TYS
STL-TYS
SGF-TYS
COU-TYS
MCI-TYS
What is the cheapest month to book a flight from Missouri to Knoxville?
Currently, August is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $75). Flying from Missouri to Knoxville in February is currently the most expensive (average of $312). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Knoxville?
Related info for your journey
Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to Knoxville
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Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Knoxville by cabin class
Find flights from Missouri to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 17, 2026.
Missouri and Knoxville flights
Browse other Missouri and Knoxville flight options. Last updated on June 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Knoxville flights
Consider these flights traveling from Missouri to Knoxville.
Top 4 airlines flying from Missouri to Knoxville
Discover the top 4 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$348 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$228 | Average$376 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$362 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$256 | Average$380 | FlexibilityNo cancel fee | On-time69% |