$97+ Cheap flights from Missouri to Knoxville (TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Oct 30 — Nov 61
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Knoxville
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Cheapest flights from Missouri to KnoxvilleExplore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 30, 2026.
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop16h 28m
Thu 11/55:37 pm -
1 stop16h 09m
Deal found 9/29![Multiple Airlines logo]()
$226
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1711:35 am -
1 stop3h 54m
Sat 11/215:30 pm -
1 stop5h 44m
Deal found 9/30![American Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop16h 28m
Sat 11/76:23 pm -
1 stop16h 48m
Deal found 9/29![Multiple Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:59 pm -
1 stop7h 42m
Thu 11/52:09 pm -
1 stop27h 01m
Deal found 9/30![Allegiant Air logo]()
$246
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:25 am -
2 stops8h 40m
Wed 11/45:15 pm -
1 stop5h 45m
Deal found 9/28![Southwest logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/211:33 am -
1 stop9h 11m
Thu 11/52:09 pm -
1 stop27h 01m
Deal found 9/30![Allegiant Air logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop16h 28m
Wed 11/48:01 pm -
1 stop14h 30m
Deal found 9/29![Multiple Airlines logo]()
$249
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:38 pm -
1 stop3h 44m
Fri 10/305:40 am -
1 stop4h 29m
Deal found 9/28![Delta logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:59 pm -
1 stop7h 42m
Sun 11/87:00 am -
1 stop28h 43m
Deal found 9/30![Allegiant Air logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/211:33 am -
1 stop9h 11m
Sun 11/87:00 am -
1 stop28h 43m
Deal found 9/30![Allegiant Air logo]()
$258
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:10 am -
2 stops7h 30m
Tue 11/37:55 am -
2 stops12h 30m
Deal found 9/28![Southwest logo]()
$259
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:00 am -
1 stop4h 27m
Fri 12/46:17 pm -
1 stop4h 21m
Deal found 9/28![Delta logo]()
$265
Best flights from Missouri to KnoxvilleDiscover carefully curated flight deals from Missouri to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 30, 2026.
Discover carefully curated flight deals from Missouri to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 30, 2026.
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:38 pm -
1 stop3h 44m
Tue 10/206:23 pm -
1 stop6h 31m
Deal found 9/26![Delta logo]()
$243
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:25 am -
2 stops8h 40m
Wed 11/45:15 pm -
1 stop5h 45m
Deal found 9/28![Southwest logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/911:33 am -
1 stop24h 02m
Thu 11/122:09 pm -
1 stop27h 01m
Deal found 9/25![Allegiant Air logo]()
$276
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:27 am -
1 stop4h 32m
Thu 11/129:45 am -
2 stops8h 45m
Deal found 9/26![United Airlines logo]()
$292
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:40 am -
2 stops8h 38m
Mon 11/27:14 pm -
1 stop4h 28m
Deal found 9/28![American Airlines logo]()
$497
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/412:40 pm -
1 stop7h 05m
Tue 12/87:55 am -
2 stops12h 30m
Deal found 9/28![Southwest logo]()
$265
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:00 am -
2 stops7h 48m
Thu 11/125:40 pm -
1 stop5h 11m
Deal found 9/29![United Airlines logo]()
$300
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/412:40 pm -
1 stop7h 05m
Sun 12/67:05 am -
2 stops8h 00m
Deal found 9/25![Southwest logo]()
$292
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:33 am -
1 stop3h 53m
Sun 11/15:40 am -
1 stop6h 50m
Deal found 9/29![Delta logo]()
$334
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:00 am -
1 stop4h 13m
Tue 11/35:45 am -
2 stops9h 33m
Deal found 9/28![United Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:28 pm -
1 stop5h 31m
Sun 11/1512:34 pm -
1 stop4h 59m
Deal found 9/29![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:20 am -
1 stop9h 35m
Tue 10/201:00 pm -
2 stops7h 00m
Deal found 9/26![Southwest logo]()
$314
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/210:50 am -
1 stop5h 13m
Wed 2/310:45 am -
1 stop4h 43m
Deal found 9/29![United Airlines logo]()
$333
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/303:03 pm -
1 stop6h 11m
Wed 2/312:00 pm -
1 stop5h 43m
Deal found 9/26![United Airlines logo]()
$333
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:00 am -
1 stop5h 40m
Sun 10/255:40 am -
1 stop4h 29m
Deal found 9/29![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:00 am -
1 stop7h 10m
Fri 10/307:25 pm -
1 stop5h 15m
Deal found 9/25![Southwest logo]()
$342
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:44 pm -
1 stop4h 15m
Thu 10/225:40 am -
1 stop4h 49m
Deal found 9/29![Delta logo]()
$377
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:15 am -
2 stops7h 27m
Sat 10/176:00 am -
1 stop5h 39m
Deal found 9/28![United Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:28 pm -
1 stop4h 22m
Mon 11/234:32 pm -
1 stop5h 57m
Deal found 9/27![American Airlines logo]()
$529
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:40 am -
1 stop4h 05m
Sat 11/76:23 pm -
1 stop6h 33m
Deal found 9/25![Delta logo]()
$391
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:15 am -
2 stops10h 20m
Thu 11/53:40 pm -
2 stops8h 45m
Deal found 9/29![Southwest logo]()
$395
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:18 am -
2 stops9h 39m
Sat 10/315:40 pm -
1 stop5h 11m
Deal found 9/29![United Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/169:05 am -
2 stops10h 45m
Wed 11/187:05 am -
2 stops8h 25m
Deal found 9/29![Southwest logo]()
$405
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:04 am -
1 stop5h 36m
Thu 10/2910:29 am -
1 stop4h 05m
Deal found 9/29![Delta logo]()
$413
This deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:30 am -
1 stop4h 44m
Thu 10/295:40 pm -
1 stop5h 11m
Deal found 9/25![United Airlines logo]()
$395
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/23:00 pm -
2 stops7h 59m
Sat 11/76:45 am -
1 stop5h 00m
Deal found 9/30![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:00 pm -
1 stop4h 54m
Wed 11/411:59 am -
2 stops11h 59m
Deal found 9/30![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:00 am -
2 stops8h 54m
Sat 11/75:40 pm -
1 stop4h 43m
Deal found 9/30![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:46 pm -
1 stop5h 13m
Thu 10/2911:20 am -
2 stops11h 31m
Deal found 9/29![United Airlines logo]()
$406
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:46 pm -
1 stop5h 13m
Wed 10/2811:19 am -
2 stops11h 32m
Deal found 9/26![United Airlines logo]()
$406
Last-minute flights from Missouri to KnoxvilleDiscover last-minute flight deals from Missouri to Knoxville. Data last updated September 30, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Knoxville. Data last updated September 30, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:38 pm -
1 stop3h 44m
Tue 10/206:23 pm -
1 stop6h 31m
Deal found 9/26![Delta logo]()
$243
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/202:39 pm -
1 stop6h 43m
Wed 10/217:09 am -
1 stop5h 21m
Deal found 9/29![Delta logo]()
$287
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:38 pm -
1 stop3h 44m
Fri 10/305:40 am -
1 stop4h 29m
Deal found 9/28![Delta logo]()
$254
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:55 am -
2 stops8h 00m
Fri 10/307:25 pm -
1 stop5h 15m
Deal found 9/28![Southwest logo]()
$281
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:10 am -
2 stops7h 30m
Tue 11/37:55 am -
2 stops12h 30m
Deal found 9/28![Southwest logo]()
$259
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:25 am -
2 stops8h 40m
Wed 11/45:15 pm -
1 stop5h 45m
Deal found 9/28![Southwest logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:59 pm -
1 stop7h 42m
Thu 11/52:09 pm -
1 stop27h 01m
Deal found 9/30![Allegiant Air logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:59 pm -
1 stop7h 42m
Sun 11/87:00 am -
1 stop28h 43m
Deal found 9/30![Allegiant Air logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:56 am -
1 stop22h 09m
Thu 11/55:37 pm -
1 stop16h 09m
Deal found 9/29![Allegiant Air logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop16h 28m
Thu 11/55:37 pm -
1 stop16h 09m
Deal found 9/29![Multiple Airlines logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop16h 28m
Sat 11/76:23 pm -
1 stop16h 48m
Deal found 9/29![Multiple Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:43 pm -
1 stop16h 28m
Wed 11/48:01 pm -
1 stop14h 30m
Deal found 9/29![Multiple Airlines logo]()
$249
One-way flights from Missouri to KnoxvilleSearch for one-way flight options from Missouri to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 30, 2026.
Search for one-way flight options from Missouri to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:44 pm -
2 stops26h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$97
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:05 am -
1 stop4h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Delta logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:35 pm -
2 stops38h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:16 am -
1 stop30h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Allegiant Air logo]()
$139
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:30 am -
1 stop4h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![American Airlines logo]()
$144
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/249:59 am -
2 stops9h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![United Airlines logo]()
$149
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/252:55 pm -
1 stop5h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Southwest logo]()
$155
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:46 pm -
1 stop5h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![United Airlines logo]()
$158
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/208:26 am -
1 stop8h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![American Airlines logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:43 pm -
3 stops37h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:43 pm -
2 stops41h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$173
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:00 am -
2 stops7h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![United Airlines logo]()
$180
Find flight deals from Missouri to Knoxville
Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated September 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $226 (Kiwi.com) |
One-way from | $97 (Kiwi.com) |
Popular in | June |
Cheapest in | August |
Average price | $364 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 30, 2026.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Wed 11/11
10:05 am-3:15 pm
1 stop4h 10m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$122
Quickest round-trip
Kansas CityKnoxville
MCI Kansas City - TYS Knoxville McGhee Tyson
MCITYS
Kansas City
Sat 10/24
10:33 am-3:26 pm
1 stop3h 53m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$144
Kansas CityKnoxville
MCI Kansas City - TYS Knoxville McGhee Tyson
MCITYS
Kansas City
Sat 10/24
9:59 am-8:19 pm
2 stops9h 20m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$149
Kansas CityKnoxville
MCI Kansas City - TYS Knoxville McGhee Tyson
MCITYS
Kansas City
Tue 10/20
6:00 am-2:42 pm
2 stops7h 42m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$149
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Wed 11/25
2:55 pm-9:45 pm
1 stop5h 50m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$155
Kansas CityKnoxville
MCI Kansas City - TYS Knoxville McGhee Tyson
MCITYS
Kansas City
Fri 10/23
5:46 pm-11:59 pm
1 stop5h 13m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$158
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Sun 12/20
8:26 am-5:35 pm
1 stop8h 09m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$165
Kansas CityKnoxville
MCI Kansas City - TYS Knoxville McGhee Tyson
MCITYS
Kansas City
Mon 10/26
6:00 am-2:48 pm
2 stops7h 48m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$180
Kansas CityKnoxville
MCI Kansas City - TYS Knoxville McGhee Tyson
MCITYS
Kansas City
Sun 10/25
7:04 am-1:40 pm
1 stop5h 36m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$184
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Sat 12/19
5:25 am-2:30 pm
1 stop8h 05m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$185
Showing 1-10 of 47 resultsSorted by cheapest first
Best time to book a flight from Missouri to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
STL-TYS
MCI-TYS
COU-TYS
SGF-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Knoxville
USMO-TYS
STL-TYS
MCI-TYS
COU-TYS
SGF-TYS
What is the cheapest month to book a flight from Missouri to Knoxville?
Currently, August is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $317). Flying from Missouri to Knoxville in February is currently the most expensive (average of $567). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Knoxville?
Airfare is below average for this route at the moment.
Missouri to Knoxville flights typically cost between $273 and $446 in November.The cheapest round-trip price found within the last 5 days was $243 on American Airlines (Nov 17-Nov 21).
Related info for your journey
Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to Knoxville
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Complete your trip
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Search flights from Missouri to Knoxville by cabin class
Find flights from Missouri to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 30, 2026.
Missouri and Knoxville flights
Browse other Missouri and Knoxville flight options. Last updated on September 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Knoxville flights
Consider these flights traveling from Missouri to Knoxville.
Top 4 airlines flying from Missouri to Knoxville
Discover the top 4 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$210 | Average$375 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$210 | Average$408 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$351 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$256 | Average$402 | FlexibilityNo cancel fee | On-time69% |