When searching for a good deal, it’s best to be prepared for potential fluctuations in price. We recommend booking at least 44 days in advance, which can save you up to 93% on flights from Missouri to Knoxville compared to booking the week you need them. Waiting 44 days out may not be for everyone, so we have options available for flights within the next two weeks, with the lowest price starting at $285. For sooner than that we have options available in the next 3 days from $285.
Due to multiple factors, expect to potentially pay more when booking in May. For low rates, November can be a great choice for travel to Knoxville. Flights to Knoxville from Missouri in November are about $422 on average during November, but can be found for as low as $248.
When flying from Missouri to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Fly from
Fly to
Budget
$96 - $341
Route
Depart
Return
Price
Lambert-St LouisKnoxville McGhee Tyson
STL - TYS
STLTYS
Lambert-St Louis
Wed 5/1
1 stop8h 30m
Knoxville McGhee Tyson
Wed 5/8
1 stop24h 47m
Kansas CityKnoxville McGhee Tyson
MCI - TYS
MCITYS
Kansas City
Tue 8/13
1 stop20h 32m
Knoxville McGhee Tyson
Sat 8/17
1 stop16h 00m
Lambert-St LouisKnoxville McGhee Tyson
STL - TYS
STLTYS
Lambert-St Louis
Tue 5/14
1 stop16h 01m
Knoxville McGhee Tyson
Tue 5/21
1 stop23h 06m
Kansas CityKnoxville McGhee Tyson
MCI - TYS
MCITYS
Kansas City
Tue 5/21
1 stop19h 47m
Knoxville McGhee Tyson
Sat 5/25
1 stop16h 02m
Lambert-St LouisKnoxville McGhee Tyson
STL - TYS
STLTYS
Lambert-St Louis
Wed 5/8
1 stop4h 33m
Knoxville McGhee Tyson
Tue 5/14
1 stop4h 29m
Lambert-St LouisKnoxville McGhee Tyson
STL - TYS
STLTYS
Lambert-St Louis
Sat 6/15
1 stop5h 20m
Knoxville McGhee Tyson
Tue 6/25
1 stop4h 21m
Kansas CityKnoxville McGhee Tyson
MCI - TYS
MCITYS
Kansas City
Tue 6/11
1 stop9h 04m
Knoxville McGhee Tyson
Fri 6/14
1 stop4h 49m
Lambert-St LouisKnoxville McGhee Tyson
STL - TYS
STLTYS
Lambert-St Louis
Sun 4/28
1 stop17h 22m
Knoxville McGhee Tyson
Tue 4/30
1 stop5h 56m
Kansas CityKnoxville McGhee Tyson
MCI - TYS
MCITYS
Kansas City
Tue 8/13
2 stops14h 42m
Knoxville McGhee Tyson
Sat 8/17
1 stop5h 16m
No data available for this route at this time. Please check back soon.
Overall
Crew
Entertainment
Comfort
Boarding
Food
Reviews
I love the seamless way that delta ensures that my luggage is on board the plane, I get a notification that it's on board. I love boarding process, orderly and on time. Lots of room in Comfort plus and getting upgraded to first class was everything!
Overall
Crew
Entertainment
Comfort
Boarding
Food
Reviews
I love the seamless way that delta ensures that my luggage is on board the plane, I get a notification that it's on board. I love boarding process, orderly and on time. Lots of room in Comfort plus and getting upgraded to first class was everything!
Overall
Crew
Entertainment
Comfort
Boarding
Food
Reviews
I love the seamless way that delta ensures that my luggage is on board the plane, I get a notification that it's on board. I love boarding process, orderly and on time. Lots of room in Comfort plus and getting upgraded to first class was everything!
Overall
Crew
Entertainment
Comfort
Boarding
Food
Reviews
I love the seamless way that delta ensures that my luggage is on board the plane, I get a notification that it's on board. I love boarding process, orderly and on time. Lots of room in Comfort plus and getting upgraded to first class was everything!
Overall
Crew
Entertainment
Comfort
Boarding
Food
Reviews
I love the seamless way that delta ensures that my luggage is on board the plane, I get a notification that it's on board. I love boarding process, orderly and on time. Lots of room in Comfort plus and getting upgraded to first class was everything!
Overall
Crew
Entertainment
Comfort
Boarding
Food
Reviews
I love the seamless way that delta ensures that my luggage is on board the plane, I get a notification that it's on board. I love boarding process, orderly and on time. Lots of room in Comfort plus and getting upgraded to first class was everything!
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