$105+ Cheap flights from Missouri to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Jun 3 — Jun 101
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to Knoxville with Cheapflights
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Cheapest flights from Missouri to KnoxvilleExplore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 4, 2026.
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:33 pm
STL
- TYS
2 stops21h 07m
Multiple Airlines
Thu 6/43:42 pm
TYS
- STL
1 stop9h 15m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$216
This Frontier deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/42:34 pm
MCI
- TYS
1 stop27h 59m
Frontier
Mon 6/88:32 pm
TYS
- MCI
1 stop17h 28m
Frontier
Deal found 5/3![Frontier logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:19 pm
STL
- TYS
1 stop6h 20m
Multiple Airlines
Mon 6/812:49 pm
TYS
- STL
2 stops29h 41m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:19 pm
STL
- TYS
1 stop6h 18m
Multiple Airlines
Fri 6/512:40 pm
TYS
- STL
2 stops21h 15m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/91:45 pm
MCI
- TYS
1 stop28h 52m
Multiple Airlines
Mon 6/156:30 am
TYS
- MCI
2 stops31h 30m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$245
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1611:18 am
STL
- TYS
1 stop7h 52m
American Airlines
Tue 6/236:12 am
TYS
- STL
1 stop5h 25m
American Airlines
Deal found 4/30![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:35 am
STL
- TYS
2 stops8h 15m
Southwest
Tue 6/95:40 pm
TYS
- STL
1 stop7h 15m
Southwest
Deal found 5/3![Southwest logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:05 pm
MCI
- TYS
1 stop25h 11m
Multiple Airlines
Fri 6/512:49 pm
TYS
- MCI
2 stops29h 40m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$258
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:15 pm
STL
- TYS
1 stop6h 35m
Southwest
Mon 6/87:45 pm
TYS
- STL
1 stop4h 00m
Southwest
Deal found 5/1![Southwest logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/91:45 pm
MCI
- TYS
1 stop28h 52m
Frontier
Mon 6/158:32 pm
TYS
- MCI
1 stop17h 28m
Frontier
Deal found 4/30![Frontier logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/231:45 pm
MCI
- TYS
1 stop28h 52m
Multiple Airlines
Tue 6/305:02 pm
TYS
- MCI
2 stops25h 19m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/254:19 pm
STL
- TYS
1 stop20h 13m
Multiple Airlines
Fri 5/2910:03 pm
TYS
- STL
1 stop26h 54m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$271
Best flights from Missouri to KnoxvilleDiscover carefully curated flight deals from Missouri to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 4, 2026.
Discover carefully curated flight deals from Missouri to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 4, 2026.
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:05 am
STL
- TYS
1 stop8h 00m
Southwest
Wed 6/106:55 pm
TYS
- STL
1 stop5h 05m
Southwest
Deal found 5/2![Southwest logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/254:19 pm
STL
- TYS
1 stop20h 13m
Multiple Airlines
Fri 5/2910:03 pm
TYS
- STL
1 stop26h 54m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$271
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:21 pm
COU
- TYS
1 stop5h 35m
American Airlines
Sat 5/235:33 pm
TYS
- COU
1 stop5h 52m
American Airlines
Deal found 5/4![American Airlines logo]()
$308
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/287:00 am
MCI
- TYS
1 stop6h 48m
Delta
Sat 8/16:00 am
TYS
- MCI
1 stop5h 12m
Delta
Deal found 4/30![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:05 pm
SGF
- TYS
1 stop5h 25m
United Airlines
Tue 9/14:56 pm
TYS
- SGF
1 stop7h 46m
United Airlines
Deal found 5/3![United Airlines logo]()
$389
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:15 pm
STL
- TYS
1 stop6h 35m
Southwest
Mon 6/87:45 pm
TYS
- STL
1 stop4h 00m
Southwest
Deal found 5/1![Southwest logo]()
$263
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:20 am
STL
- TYS
1 stop6h 00m
Southwest
Sat 6/61:35 pm
TYS
- STL
1 stop4h 50m
Southwest
Deal found 5/2![Southwest logo]()
$277
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/62:30 pm
STL
- TYS
1 stop5h 50m
Southwest
Thu 6/117:45 pm
TYS
- STL
1 stop4h 00m
Southwest
Deal found 4/29![Southwest logo]()
$288
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/277:00 am
MCI
- TYS
1 stop6h 48m
Delta
Wed 7/297:43 pm
TYS
- MCI
1 stop5h 15m
Delta
Deal found 4/30![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/271:18 pm
MCI
- TYS
1 stop5h 47m
Delta
Sat 8/16:00 am
TYS
- MCI
1 stop5h 12m
Delta
Deal found 4/30![Delta logo]()
$354
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/2510:15 am
STL
- TYS
2 stops9h 05m
Southwest
Fri 5/296:35 am
TYS
- STL
2 stops7h 15m
Southwest
Deal found 5/4![Southwest logo]()
$306
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:19 pm
COU
- TYS
1 stop5h 36m
American Airlines
Sun 6/145:37 am
TYS
- COU
1 stop6h 37m
American Airlines
Deal found 5/3![American Airlines logo]()
$416
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:00 am
MCI
- TYS
1 stop6h 48m
Delta
Tue 8/45:40 am
TYS
- MCI
1 stop4h 43m
Delta
Deal found 4/30![Delta logo]()
$376
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:40 pm
STL
- TYS
2 stops7h 30m
Southwest
Mon 6/227:30 am
TYS
- STL
2 stops12h 00m
Southwest
Deal found 4/29![Southwest logo]()
$315
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:25 pm
COU
- TYS
1 stop4h 31m
United Airlines
Sun 6/76:00 am
TYS
- COU
1 stop5h 13m
United Airlines
Deal found 5/3![United Airlines logo]()
$478
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:25 pm
MCI
- TYS
1 stop3h 50m
Delta
Sun 6/211:59 pm
TYS
- MCI
1 stop5h 57m
Delta
Deal found 5/3![Delta logo]()
$392
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:28 pm
COU
- TYS
1 stop17h 29m
American Airlines
Tue 5/196:54 pm
TYS
- COU
1 stop4h 59m
American Airlines
Deal found 4/30![American Airlines logo]()
$491
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/135:00 am
MCI
- TYS
1 stop8h 05m
Southwest
Thu 6/186:40 am
TYS
- MCI
2 stops7h 50m
Southwest
Deal found 4/29![Southwest logo]()
$357
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:47 pm
COU
- TYS
1 stop4h 06m
American Airlines
Fri 6/126:07 pm
TYS
- COU
1 stop5h 39m
American Airlines
Deal found 4/30![American Airlines logo]()
$506
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/42:10 pm
MCI
- TYS
2 stops7h 20m
Southwest
Mon 6/87:45 pm
TYS
- MCI
1 stop5h 25m
Southwest
Deal found 5/3![Southwest logo]()
$389
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/83:25 pm
COU
- TYS
1 stop4h 31m
United Airlines
Fri 6/127:19 pm
TYS
- COU
2 stops26h 20m
United Airlines
Deal found 4/30![United Airlines logo]()
$627
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/299:55 am
MCI
- TYS
2 stops9h 25m
Southwest
Sat 8/17:00 am
TYS
- MCI
2 stops6h 35m
Southwest
Deal found 4/30![Southwest logo]()
$392
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:00 am
COU
- TYS
2 stops8h 27m
United Airlines
Sun 6/146:30 am
TYS
- COU
1 stop16h 29m
United Airlines
Deal found 4/29![United Airlines logo]()
$638
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:00 am
COU
- TYS
1 stop7h 19m
United Airlines
Sun 6/145:45 am
TYS
- COU
2 stops17h 14m
United Airlines
Deal found 4/29![United Airlines logo]()
$642
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/142:30 pm
MCI
- TYS
2 stops5h 45m
Southwest
Sat 6/208:00 am
TYS
- MCI
1 stop10h 10m
Southwest
Deal found 5/1![Southwest logo]()
$418
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:35 am
MCI
- TYS
2 stops8h 45m
Southwest
Wed 6/37:05 am
TYS
- MCI
2 stops7h 30m
Southwest
Deal found 5/1![Southwest logo]()
$426
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/243:10 pm
SGF
- TYS
1 stop4h 38m
United Airlines
Fri 8/281:35 pm
TYS
- SGF
2 stops9h 23m
United Airlines
Deal found 5/2![United Airlines logo]()
$703
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:35 am
MCI
- TYS
1 stop3h 25m
Southwest
Sat 5/236:40 am
TYS
- MCI
1 stop3h 55m
Southwest
Deal found 5/3![Southwest logo]()
$437
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/112:05 pm
MCI
- TYS
2 stops7h 15m
Southwest
Sun 6/78:00 am
TYS
- MCI
2 stops6h 35m
Southwest
Deal found 5/3![Southwest logo]()
$437
Last-minute flights from Missouri to KnoxvilleDiscover last-minute flight deals from Missouri to Knoxville. Data last updated May 4, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Knoxville. Data last updated May 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/254:19 pm
STL
- TYS
1 stop20h 13m
Multiple Airlines
Fri 5/2910:03 pm
TYS
- STL
1 stop26h 54m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$271
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:15 am
STL
- TYS
1 stop5h 55m
Southwest
Fri 5/296:45 pm
TYS
- STL
1 stop3h 10m
Southwest
Deal found 4/29![Southwest logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:33 pm
STL
- TYS
2 stops21h 07m
Multiple Airlines
Thu 6/43:42 pm
TYS
- STL
1 stop9h 15m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$216
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:10 pm
STL
- TYS
2 stops6h 05m
Southwest
Thu 6/46:40 am
TYS
- STL
2 stops7h 55m
Southwest
Deal found 4/30![Southwest logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:19 pm
STL
- TYS
1 stop6h 18m
Multiple Airlines
Fri 6/512:40 pm
TYS
- STL
2 stops21h 15m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:05 pm
MCI
- TYS
1 stop25h 11m
Multiple Airlines
Fri 6/512:49 pm
TYS
- MCI
2 stops29h 40m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$258
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3012:30 pm
STL
- TYS
1 stop6h 05m
Southwest
Sat 6/61:35 pm
TYS
- STL
1 stop4h 50m
Southwest
Deal found 4/29![Southwest logo]()
$277
This Frontier deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/42:34 pm
MCI
- TYS
1 stop27h 59m
Frontier
Mon 6/88:32 pm
TYS
- MCI
1 stop17h 28m
Frontier
Deal found 5/3![Frontier logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/91:45 pm
MCI
- TYS
1 stop28h 52m
Multiple Airlines
Mon 6/156:30 am
TYS
- MCI
2 stops31h 30m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/91:45 pm
MCI
- TYS
1 stop28h 52m
Frontier
Mon 6/158:32 pm
TYS
- MCI
1 stop17h 28m
Frontier
Deal found 4/30![Frontier logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/231:45 pm
MCI
- TYS
1 stop28h 52m
Multiple Airlines
Tue 6/305:02 pm
TYS
- MCI
2 stops25h 19m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$267
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/239:30 am
MCI
- TYS
1 stop6h 30m
Southwest
Tue 6/305:40 pm
TYS
- MCI
1 stop6h 55m
Southwest
Deal found 4/29![Southwest logo]()
$295
One-way flights from Missouri to KnoxvilleSearch for one-way flight options from Missouri to Knoxville. Find affordable one-way fares based on user searches. Data last updated May 4, 2026.
Search for one-way flight options from Missouri to Knoxville. Find affordable one-way fares based on user searches. Data last updated May 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:31 pm
STL
- TYS
2 stops26h 19m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:19 pm
STL
- TYS
1 stop6h 18m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:16 pm
MCI
- TYS
2 stops19h 32m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$147
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:30 am
MCI
- TYS
1 stop6h 32m
American Airlines
Deal found 5/2![American Airlines logo]()
$148
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:12 pm
STL
- TYS
1 stop4h 35m
American Airlines
Deal found 4/30![American Airlines logo]()
$150
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:20 pm
MCI
- TYS
2 stops7h 30m
Southwest
Deal found 5/2![Southwest logo]()
$153
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:10 pm
STL
- TYS
2 stops6h 05m
Southwest
Deal found 4/30![Southwest logo]()
$155
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:16 pm
MCI
- TYS
1 stop5h 31m
American Airlines
Deal found 5/2![American Airlines logo]()
$156
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:45 pm
MCI
- TYS
1 stop5h 09m
United Airlines
Deal found 5/3![United Airlines logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/184:35 pm
MCI
- TYS
1 stop21h 23m
Allegiant Air
Deal found 4/30![Allegiant Air logo]()
$169
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/510:40 am
MCI
- TYS
1 stop6h 09m
Allegiant Air
Deal found 5/2![Allegiant Air logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:24 pm
MCI
- TYS
3 stops25h 06m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$172
Find flight deals from Missouri to Knoxville
Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated May 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $216 (Kiwi.com) |
One-way from | $105 (Kiwi.com) |
Popular in | January |
Cheapest in | August |
Average price | $322 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 4, 2026.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Sat 6/6
5:05 am-2:05 pm
1 stop8h 00m
Knoxville McGhee Tyson
Wed 6/10
6:55 pm-11:00 pm
1 stop5h 05m
$263
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Wed 6/3
1:15 pm-8:50 pm
1 stop6h 35m
Knoxville McGhee Tyson
Mon 6/8
7:45 pm-10:45 pm
1 stop4h 00m
$263
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Mon 5/25
4:19 pm-1:32 pm
1 stop20h 13m
Knoxville McGhee Tyson
Fri 5/29
10:03 pm-11:57 pm
1 stop26h 54m
$271
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Sat 5/30
6:20 am-1:20 pm
1 stop6h 00m
Knoxville McGhee Tyson
Sat 6/6
1:35 pm-5:25 pm
1 stop4h 50m
$277
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Sat 6/6
2:30 pm-9:20 pm
1 stop5h 50m
Knoxville McGhee Tyson
Thu 6/11
7:45 pm-10:45 pm
1 stop4h 00m
$288
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Mon 5/25
10:15 am-8:20 pm
2 stops9h 05m
Knoxville McGhee Tyson
Fri 5/29
6:35 am-12:50 pm
2 stops7h 15m
$306
ColumbiaKnoxville
COU - TYS
COUTYS
Columbia Regional
Tue 5/19
5:21 pm-11:56 pm
1 stop5h 35m
Knoxville McGhee Tyson
Sat 5/23
5:33 pm-10:25 pm
1 stop5h 52m
$308
St. LouisKnoxville
STL - TYS
STLTYS
Lambert-St Louis
Thu 6/18
12:40 pm-9:10 pm
2 stops7h 30m
Knoxville McGhee Tyson
Mon 6/22
7:30 am-6:30 pm
2 stops12h 00m
$315
Kansas CityKnoxville
MCI - TYS
MCITYS
Kansas City
Tue 7/28
7:00 am-2:48 pm
1 stop6h 48m
Knoxville McGhee Tyson
Sat 8/1
6:00 am-10:12 am
1 stop5h 12m
$339
Kansas CityKnoxville
MCI - TYS
MCITYS
Kansas City
Mon 7/27
7:00 am-2:48 pm
1 stop6h 48m
Knoxville McGhee Tyson
Wed 7/29
7:43 pm-11:58 pm
1 stop5h 15m
$354
Showing 1-10 of 50 resultsSorted by cheapest first
Best time to book a flight from Missouri to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
STL-TYS
COU-TYS
MCI-TYS
SGF-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Knoxville
USMO-TYS
STL-TYS
COU-TYS
MCI-TYS
SGF-TYS
What is the cheapest month to book a flight from Missouri to Knoxville?
Currently, August is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $75). Flying from Missouri to Knoxville in February is currently the most expensive (average of $312). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Knoxville?
Related info for your journey
Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
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Alternative routes for Missouri to Knoxville
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Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Knoxville by cabin class
Find flights from Missouri to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 4, 2026.
Missouri and Knoxville flights
Browse other Missouri and Knoxville flight options. Last updated on May 4, 2026.
Popular flight searches
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Missouri to Knoxville flights
Consider these flights traveling from Missouri to Knoxville.
Top 4 airlines flying from Missouri to Knoxville
Discover the top 4 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$202 | Average$362 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$213 | Average$333 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$228 | Average$354 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$256 | Average$385 | FlexibilityNo cancel fee | On-time69% |