$94+ Cheap flights from Missouri to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Sep 11 — Sep 181
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Missouri to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Missouri to KnoxvilleExplore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 12, 2026.
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 12, 2026.
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:00 am -
1 stop6h 30m
Wed 9/168:15 pm -
1 stop5h 12m
Deal found 8/11![American Airlines logo]()
$205
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:05 am -
1 stop6h 15m
Tue 10/64:20 pm -
1 stop7h 50m
Deal found 8/10![Southwest logo]()
$206
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:50 am -
1 stop5h 25m
Wed 9/167:00 am -
2 stops8h 50m
Deal found 8/10![Southwest logo]()
$210
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:40 pm -
1 stop5h 10m
Sat 9/51:55 pm -
1 stop8h 45m
Deal found 8/11![Southwest logo]()
$215
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:50 pm -
1 stop5h 28m
Tue 9/1511:08 am -
1 stop6h 19m
Deal found 8/11![American Airlines logo]()
$228
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/212:59 pm -
1 stop6h 54m
Sun 9/66:02 pm -
1 stop5h 57m
Deal found 8/11![United Airlines logo]()
$231
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/81:40 pm -
1 stop5h 15m
Tue 9/158:05 am -
2 stops8h 05m
Deal found 8/11![Southwest logo]()
$233
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:45 am -
2 stops8h 10m
Wed 9/167:00 am -
2 stops8h 50m
Deal found 8/11![Southwest logo]()
$238
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:02 am -
1 stop5h 27m
Sat 10/106:55 pm -
1 stop6h 33m
Deal found 8/11![American Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:35 am -
2 stops10h 30m
Sun 11/86:30 am -
1 stop13h 45m
Deal found 8/11![Multiple Airlines logo]()
$245
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/99:20 am -
2 stops9h 35m
Wed 9/167:00 am -
1 stop3h 45m
Deal found 8/10![Southwest logo]()
$246
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:27 am -
1 stop4h 03m
Thu 9/178:15 pm -
1 stop5h 12m
Deal found 8/7![American Airlines logo]()
$247
Best flights from Missouri to KnoxvilleDiscover carefully curated flight deals from Missouri to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 12, 2026.
Discover carefully curated flight deals from Missouri to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 12, 2026.
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:45 am -
2 stops8h 05m
Sat 9/51:55 pm -
1 stop8h 45m
Deal found 8/11![Southwest logo]()
$220
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/212:59 pm -
1 stop6h 54m
Sun 9/66:02 pm -
1 stop5h 57m
Deal found 8/11![United Airlines logo]()
$231
This Delta deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop6h 31m
Sun 11/87:25 pm -
1 stop5h 31m
Deal found 8/11![Delta logo]()
$303
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:00 am -
1 stop5h 56m
Tue 9/17:19 am -
1 stop4h 38m
Deal found 8/10![American Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/243:51 pm -
1 stop5h 05m
Mon 9/287:04 pm -
1 stop15h 54m
Deal found 8/10![Allegiant Air logo]()
$397
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:40 pm -
1 stop5h 15m
Wed 9/167:00 am -
2 stops8h 50m
Deal found 8/11![Southwest logo]()
$233
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:40 am -
1 stop4h 45m
Wed 9/235:30 pm -
1 stop5h 45m
Deal found 8/7![Southwest logo]()
$247
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:11 pm -
1 stop4h 38m
Thu 10/16:00 am -
1 stop7h 13m
Deal found 8/10![United Airlines logo]()
$283
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:14 pm -
1 stop4h 39m
Sun 9/65:45 am -
2 stops7h 35m
Deal found 8/10![United Airlines logo]()
$292
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2910:45 am -
2 stops7h 15m
Tue 10/68:20 am -
2 stops7h 40m
Deal found 8/10![Southwest logo]()
$268
This Delta deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:58 pm -
1 stop3h 56m
Tue 9/16:12 pm -
1 stop5h 09m
Deal found 8/11![Delta logo]()
$334
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:15 am -
1 stop4h 31m
Tue 8/257:19 am -
1 stop4h 38m
Deal found 8/8![American Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/129:00 am -
2 stops7h 45m
Wed 9/167:00 am -
2 stops8h 50m
Deal found 8/10![Southwest logo]()
$277
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1212:28 pm -
2 stops9h 21m
Wed 9/166:00 pm -
1 stop4h 31m
Deal found 8/11![United Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/253:11 pm -
1 stop4h 42m
Sat 8/295:45 am -
2 stops9h 45m
Deal found 8/10![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:28 am -
1 stop6h 25m
Mon 9/218:15 pm -
1 stop5h 08m
Deal found 8/7![American Airlines logo]()
$418
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:00 am -
1 stop7h 10m
Tue 10/68:20 am -
2 stops7h 40m
Deal found 8/8![Southwest logo]()
$324
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
2 stops7h 42m
Sat 10/1010:42 am -
1 stop6h 11m
Deal found 8/11![United Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:50 am -
1 stop5h 25m
Thu 9/177:10 am -
2 stops9h 10m
Deal found 8/8![Southwest logo]()
$324
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:00 pm -
1 stop4h 54m
Sat 10/3110:51 am -
1 stop4h 27m
Deal found 8/10![United Airlines logo]()
$358
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:45 am -
2 stops8h 05m
Sun 9/61:30 pm -
1 stop9h 10m
Deal found 8/11![Southwest logo]()
$341
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:30 am -
2 stops11h 54m
Sat 8/299:45 am -
2 stops9h 17m
Deal found 8/10![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/83:35 pm -
1 stop6h 05m
Thu 10/1512:50 pm -
1 stop8h 20m
Deal found 8/10![Southwest logo]()
$354
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:49 am -
2 stops8h 35m
Sat 8/226:02 pm -
1 stop5h 53m
Deal found 8/9![United Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:14 pm -
2 stops7h 45m
Wed 9/99:45 am -
2 stops8h 58m
Deal found 8/11![United Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/811:20 am -
1 stop7h 35m
Tue 9/158:05 am -
2 stops9h 05m
Deal found 8/9![Southwest logo]()
$372
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:00 am -
2 stops12h 45m
Fri 11/203:40 pm -
1 stop5h 35m
Deal found 8/11![Southwest logo]()
$378
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:03 pm -
2 stops7h 56m
Mon 8/242:21 pm -
1 stop5h 34m
Deal found 8/10![United Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:55 am -
1 stop4h 25m
Mon 9/145:45 pm -
2 stops6h 35m
Deal found 8/8![Southwest logo]()
$392
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:14 pm -
1 stop4h 39m
Mon 9/77:00 am -
1 stop4h 25m
Deal found 8/8![United Airlines logo]()
$413
Last-minute flights from Missouri to KnoxvilleDiscover last-minute flight deals from Missouri to Knoxville. Data last updated August 12, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Knoxville. Data last updated August 12, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:40 pm -
1 stop5h 10m
Sat 9/51:55 pm -
1 stop8h 45m
Deal found 8/11![Southwest logo]()
$215
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/212:59 pm -
1 stop6h 54m
Sun 9/66:02 pm -
1 stop5h 57m
Deal found 8/11![United Airlines logo]()
$231
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:50 pm -
1 stop5h 28m
Tue 9/1511:08 am -
1 stop6h 19m
Deal found 8/11![American Airlines logo]()
$228
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/81:40 pm -
1 stop5h 15m
Tue 9/158:05 am -
2 stops8h 05m
Deal found 8/11![Southwest logo]()
$233
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:14 pm -
1 stop5h 04m
Tue 9/156:15 am -
1 stop4h 49m
Deal found 8/11![American Airlines logo]()
$251
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:45 am -
2 stops8h 10m
Wed 9/167:00 am -
2 stops8h 50m
Deal found 8/11![Southwest logo]()
$238
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:16 am -
1 stop4h 34m
Wed 9/166:00 am -
1 stop5h 40m
Deal found 8/10![American Airlines logo]()
$239
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/99:20 am -
2 stops9h 35m
Wed 9/167:00 am -
1 stop3h 45m
Deal found 8/10![Southwest logo]()
$246
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:00 am -
1 stop6h 30m
Wed 9/168:15 pm -
1 stop5h 12m
Deal found 8/11![American Airlines logo]()
$205
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:50 am -
1 stop5h 25m
Wed 9/167:00 am -
2 stops8h 50m
Deal found 8/10![Southwest logo]()
$210
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:27 am -
1 stop4h 03m
Thu 9/178:15 pm -
1 stop5h 12m
Deal found 8/7![American Airlines logo]()
$247
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:05 am -
1 stop6h 15m
Tue 10/64:20 pm -
1 stop7h 50m
Deal found 8/10![Southwest logo]()
$206
One-way flights from Missouri to KnoxvilleSearch for one-way flight options from Missouri to Knoxville. Find affordable one-way fares based on user searches. Data last updated August 12, 2026.
Search for one-way flight options from Missouri to Knoxville. Find affordable one-way fares based on user searches. Data last updated August 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:17 pm -
1 stop22h 02m
Deal found 8/8![Multiple Airlines logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:35 am -
2 stops10h 30m
Deal found 8/10![Multiple Airlines logo]()
$94
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:05 am -
1 stop5h 50m
Deal found 8/10![Delta logo]()
$107
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:40 pm -
1 stop5h 25m
Deal found 8/9![Southwest logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3110:39 am -
1 stop26h 56m
Deal found 8/9![Allegiant Air logo]()
$125
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:05 am -
1 stop6h 15m
Deal found 8/11![Southwest logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:17 pm -
2 stops45h 04m
Deal found 8/9![Multiple Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/235:02 pm -
1 stop19h 03m
Deal found 8/7![Multiple Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:13 pm -
1 stop24h 22m
Deal found 8/10![Allegiant Air logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:29 pm -
2 stops21h 35m
Deal found 8/11![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:21 am -
1 stop9h 17m
Deal found 8/10![Allegiant Air logo]()
$142
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:00 am -
1 stop6h 46m
Deal found 8/11![American Airlines logo]()
$144
Find flight deals from Missouri to Knoxville
Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated August 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $205 (American Airlines) |
One-way from | $94 (Kiwi.com) |
Popular in | February |
Cheapest in | August |
Average price | $331 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Tue 9/1
10:45 am-7:50 pm
2 stops8h 05m
Knoxville McGhee Tyson
Sat 9/5
1:55 pm-9:40 pm
1 stop8h 45m
$220
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Wed 9/2
12:59 pm-8:53 pm
1 stop6h 54m
Knoxville McGhee Tyson
Sun 9/6
6:02 pm-10:59 pm
1 stop5h 57m
$231
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Wed 9/9
1:40 pm-7:55 pm
1 stop5h 15m
Knoxville McGhee Tyson
Wed 9/16
7:00 am-2:50 pm
2 stops8h 50m
$233
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Mon 9/21
7:40 am-1:25 pm
1 stop4h 45m
Knoxville McGhee Tyson
Wed 9/23
5:30 pm-10:15 pm
1 stop5h 45m
$247
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Tue 9/29
10:45 am-7:00 pm
2 stops7h 15m
Knoxville McGhee Tyson
Tue 10/6
8:20 am-3:00 pm
2 stops7h 40m
$268
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Sat 9/12
9:00 am-5:45 pm
2 stops7h 45m
Knoxville McGhee Tyson
Wed 9/16
7:00 am-2:50 pm
2 stops8h 50m
$277
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Mon 9/28
3:11 pm-8:49 pm
1 stop4h 38m
Knoxville McGhee Tyson
Thu 10/1
6:00 am-12:13 pm
1 stop7h 13m
$283
Kansas CityKnoxville
MCI Kansas City - TYS Knoxville McGhee Tyson
MCITYS
Kansas City
Sat 9/5
3:14 pm-8:53 pm
1 stop4h 39m
Knoxville McGhee Tyson
Sun 9/6
5:45 am-12:20 pm
2 stops7h 35m
$292
Kansas CityKnoxville
MCI Kansas City - TYS Knoxville McGhee Tyson
MCITYS
Kansas City
Sat 11/7
6:00 am-1:31 pm
1 stop6h 31m
Knoxville McGhee Tyson
Sun 11/8
7:25 pm-11:56 pm
1 stop5h 31m
$303
St. LouisKnoxville
STL Lambert-St Louis - TYS Knoxville McGhee Tyson
STLTYS
Lambert-St Louis
Sat 9/12
12:28 pm-10:49 pm
2 stops9h 21m
Knoxville McGhee Tyson
Wed 9/16
6:00 pm-9:31 pm
1 stop4h 31m
$308
Showing 1-10 of 58 resultsSorted by cheapest first
Best time to book a flight from Missouri to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
STL-TYS
MCI-TYS
COU-TYS
SGF-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Knoxville
USMO-TYS
STL-TYS
MCI-TYS
COU-TYS
SGF-TYS
What is the cheapest month to book a flight from Missouri to Knoxville?
Currently, August is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $321). Flying from Missouri to Knoxville in February is currently the most expensive (average of $567). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Knoxville?
Airfare is below average for this route at the moment.
Missouri to Knoxville flights typically cost between $252 and $328 in September.The cheapest round-trip price found within the last 5 days was $205 on American Airlines (Sep 12-Sep 16).
Related info for your journey
Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Popular flights
Top destinations
Alternative routes for Missouri to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Knoxville by cabin class
Find flights from Missouri to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 12, 2026.
Missouri and Knoxville flights
Browse other Missouri and Knoxville flight options. Last updated on August 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Knoxville flights
Consider these flights traveling from Missouri to Knoxville.
Top 4 airlines flying from Missouri to Knoxville
Discover the top 4 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$217 | Average$397 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$399 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$351 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$256 | Average$406 | FlexibilityNo cancel fee | On-time69% |