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$101+ Cheap flights from Knoxville (TYS) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — JAN
Jul 6 — Jul 131
Sun 7/6
Sun 7/13
1 adult, Economy
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Cheap flight deals from Knoxville to Mississippi

Keep the following information in mind while searching for Knoxville to Mississippi flight deals. Data was last updated July 1, 2025.

Round-trip from

$229
(Delta)

One-way from

$101
(Mytrip)

Popular in

March

Cheapest in

April

Average price

$418
From Knoxville McGhee Tyson to Mississippi
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One-way flight from Knoxville McGhee Tyson to Mississippi
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Highest demand for flights based on searches. 5% potential increase in price ($20 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Knoxville to Mississippi

Cheapest flights from Knoxville to Mississippi
Explore the most affordable flight options available from Knoxville to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/206:14 pmTYS - JAN
1 stop6h 06mDelta
Sat 8/2312:11 pmJAN - TYS
1 stop3h 58mDelta
Deal found 6/29$229
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/257:43 pmTYS - GPT
1 stop3h 20mDelta
Sun 7/276:07 amGPT - TYS
1 stop4h 01mDelta
Deal found 6/30$229
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/155:05 amTYS - JAN
1 stop6h 23mAmerican Airlines
Sat 7/194:10 pmJAN - TYS
1 stop5h 15mAmerican Airlines
Deal found 6/30$239
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/105:06 amTYS - MEM
1 stop4h 16mAmerican Airlines
Mon 8/186:50 amMEM - TYS
1 stop3h 32mAmerican Airlines
Deal found 6/30$247
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:08 pmTYS - BTR
1 stop5h 04mDelta
Tue 9/3010:27 amBTR - TYS
1 stop5h 36mDelta
Deal found 6/30$249
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/267:45 pmTYS - BTR
1 stop4h 21mAmerican Airlines
Tue 9/3010:08 amBTR - TYS
2 stops7h 42mAmerican Airlines
Deal found 6/30$254
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/286:00 amTYS - MEM
1 stop11h 29mMultiple Airlines
Mon 8/45:34 pmMEM - TYS
2 stops21h 31mMultiple Airlines
Deal found 6/30$273
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/147:43 pmTYS - MEM
1 stop5h 01mDelta
Mon 7/214:56 pmMEM - TYS
1 stop6h 03mDelta
Deal found 6/30$286
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/305:45 amTYS - MOB
1 stop3h 47mDelta
Wed 9/31:00 pmMOB - TYS
1 stop3h 19mDelta
Deal found 6/29$297
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/29:35 amTYS - MEM
1 stop5h 18mUnited Airlines
Sat 7/53:27 pmMEM - TYS
1 stop7h 00mUnited Airlines
Deal found 7/1$349
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2010:36 amTYS - MOB
2 stops11h 11mAmerican Airlines
Sun 8/245:10 amMOB - TYS
1 stop4h 20mAmerican Airlines
Deal found 6/29$373
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/298:25 pmTYS - GPT
1 stop4h 27mAmerican Airlines
Mon 9/112:43 pmGPT - TYS
1 stop3h 55mAmerican Airlines
Deal found 6/30$397

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
Use the filters below to find and compare flights from Knoxville to Mississippi that are best for you.

Fly from

Knoxville

Fly to

Mississippi

Route

Depart

Return

Price

KnoxvilleJackson

TYS - JAN

TYSJAN

Knoxville McGhee Tyson

Wed 8/20

6:14 pm-11:20 pm

1 stop6h 06m

Jackson-Evers Intl

Sat 8/23

12:11 pm-5:09 pm

1 stop3h 58m

$229

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Fri 7/25

7:43 pm-10:03 pm

1 stop3h 20m

Gulfport Biloxi Regional

Sun 7/27

6:07 am-11:08 am

1 stop4h 01m

$229

KnoxvilleJackson

TYS - JAN

TYSJAN

Knoxville McGhee Tyson

Tue 7/15

5:05 am-10:28 am

1 stop6h 23m

Jackson-Evers Intl

Sat 7/19

4:10 pm-10:25 pm

1 stop5h 15m

$239

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Sun 8/10

5:06 am-8:22 am

1 stop4h 16m

Memphis

Mon 8/18

6:50 am-11:22 am

1 stop3h 32m

$247

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Fri 9/26

6:08 pm-10:12 pm

1 stop5h 04m

Baton Rouge Ryan

Tue 9/30

10:27 am-5:03 pm

1 stop5h 36m

$249

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Fri 9/26

7:45 pm-11:06 pm

1 stop4h 21m

Baton Rouge Ryan

Tue 9/30

10:08 am-6:50 pm

2 stops7h 42m

$254

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Mon 7/28

6:00 am-4:29 pm

1 stop11h 29m

Memphis

Mon 8/4

5:34 pm-4:05 pm

2 stops21h 31m

$273

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Mon 7/14

7:43 pm-11:44 pm

1 stop5h 01m

Memphis

Mon 7/21

4:56 pm-11:59 pm

1 stop6h 03m

$286

KnoxvilleMobile

TYS - MOB

TYSMOB

Knoxville McGhee Tyson

Sat 8/30

5:45 am-8:32 am

1 stop3h 47m

Mobile

Wed 9/3

1:00 pm-5:19 pm

1 stop3h 19m

$297

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Tue 7/15

7:00 am-11:02 am

1 stop5h 02m

Memphis

Sat 7/19

2:46 pm-10:35 pm

1 stop6h 49m

$328

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Showing 1-10 of 27 results
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Best time to book a flight from Knoxville to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mississippi

What is the cheapest month to book a flight from Knoxville to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $371). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MS?

Find hourly flight availability from Knoxville to Mississippi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

When flying from Knoxville to Mississippi, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated July 1, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Mississippi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,973 reviews
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,858 reviews
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
710 reviews
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mississippi?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Mississippi. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to Mississippi one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $101. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from Knoxville to Mississippi for a low price.

  • What are the most popular routes from Knoxville to Mississippi?

    While some choose either Knoxville McGhee Tyson - Baton Rouge Ryan or Knoxville McGhee Tyson - Mobile, Knoxville McGhee Tyson - Memphis is the most popular route from Knoxville to Mississippi.

  • Can I find deals for flights from Knoxville to Mississippi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mississippi.

  • Can I find deals for business class flights from Knoxville to Mississippi?

    Yes. Cheapflights offers flight deals from Knoxville to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $371). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to Mississippi

Discover the top 2 airlines that operate flights from Knoxville to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$386FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$318FlexibilityNo cancel feeOn-timeN/A

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