Mississippi

$104+ Cheap flights from Knoxville (TYS) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/24. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — JAN
Mai 23 — Mai 301
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Cheap flight deals from Knoxville to Mississippi

Cheapest flights from Knoxville to Mississippi
Explore the most affordable flight options available from Knoxville to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 5/287:27 pm
TYS
-
MEM
1 stop23h 56m
Multiple Airlines
Mo 6/15:04 pm
MEM
-
TYS
1 stop22h 11m
Multiple Airlines
Deal found 4/20$208
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 5/81:15 pm
TYS
-
MEM
1 stop28h 17m
Multiple Airlines
Mo 5/118:05 am
MEM
-
TYS
1 stop24h 35m
Multiple Airlines
Deal found 4/18$225
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 4/309:25 pm
TYS
-
MEM
1 stop21h 24m
Allegiant Air
So 5/37:55 pm
MEM
-
TYS
1 stop21h 20m
Allegiant Air
Deal found 4/18$229
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 5/205:40 am
TYS
-
JAN
1 stop4h 14m
Delta
Mi 5/279:34 am
JAN
-
TYS
1 stop3h 59m
Delta
Deal found 4/21$233
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 5/141:14 pm
TYS
-
MEM
1 stop5h 56m
Multiple Airlines
So 5/175:37 pm
MEM
-
TYS
1 stop27h 47m
Multiple Airlines
Deal found 4/21$238
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 5/265:40 am
TYS
-
MEM
1 stop5h 55m
Delta
Mi 5/278:30 am
MEM
-
TYS
1 stop3h 40m
Delta
Deal found 4/21$243
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 5/141:14 pm
TYS
-
MEM
1 stop5h 56m
Multiple Airlines
Fr 5/155:37 pm
MEM
-
TYS
1 stop23h 26m
Multiple Airlines
Deal found 4/20$244
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 5/75:10 pm
TYS
-
MEM
1 stop15h 05m
Multiple Airlines
Fr 5/87:03 pm
MEM
-
TYS
1 stop17h 06m
Multiple Airlines
Deal found 4/22$245
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 5/75:10 pm
TYS
-
MEM
1 stop15h 05m
Allegiant Air
Mo 5/118:05 am
MEM
-
TYS
1 stop24h 35m
Allegiant Air
Deal found 4/22$246
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 8/247:10 am
TYS
-
JAN
2 stops5h 50m
Southwest
Di 8/251:30 pm
JAN
-
TYS
1 stop4h 25m
Southwest
Deal found 4/20$249
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 5/75:10 pm
TYS
-
MEM
1 stop15h 05m
Allegiant Air
Do 5/147:00 pm
MEM
-
TYS
1 stop25h 48m
Allegiant Air
Deal found 4/21$251
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 5/17:30 am
TYS
-
MEM
1 stop11h 19m
Allegiant Air
So 5/37:55 pm
MEM
-
TYS
1 stop24h 53m
Allegiant Air
Deal found 4/21$254

Find flight deals from Knoxville to Mississippi

Keep the following information in mind while searching for Knoxville to Mississippi flight deals. Data was last updated April 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$208
(Kiwi.com)

One-way from

$104
(Kiwi.com)

Popular in

September

Cheapest in

June

Average price

$436
Provider with most accurate pricing for Knoxville McGhee Tyson-Jackson-Evers Intl flight deals.
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Jackson-Evers Intl flights.
From Knoxville McGhee Tyson to Mississippi
One-way flight from Knoxville McGhee Tyson to Mississippi
Highest demand for flights based on searches. 9% potential increase in price ($46 potential increase over avg. RT price).
Cheapest flight prices on average. 9% potential price decrease ($37 potential savings vs. average RT price).
Average for round-trip flights in April 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from Knoxville to Mississippi that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Fr 5/8

1:15 pm-4:32 pm

1 stop28h 17m

Memphis

Mo 5/11

8:05 am-9:40 am

1 stop24h 35m

$225

KnoxvilleJackson

TYS - JAN

TYSJAN

Knoxville McGhee Tyson

Mo 8/24

7:10 am-12:00 pm

2 stops5h 50m

Jackson-Evers Intl

Di 8/25

1:30 pm-6:55 pm

1 stop4h 25m

$249

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Do 5/14

5:00 am-8:18 am

1 stop4h 18m

Memphis

Di 5/19

5:38 pm-10:56 pm

1 stop4h 18m

$283

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Do 5/7

9:40 pm-4:32 pm

2 stops19h 52m

Memphis

Mo 5/11

8:05 am-9:40 am

1 stop24h 35m

$319

KnoxvilleJackson

TYS - JAN

TYSJAN

Knoxville McGhee Tyson

Di 6/2

5:40 am-8:54 am

1 stop4h 14m

Jackson-Evers Intl

Fr 6/12

9:39 am-2:49 pm

1 stop4h 10m

$347

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Di 6/30

5:40 am-9:21 am

1 stop4h 41m

Gulfport Biloxi Regional

Di 7/7

6:00 pm-11:52 pm

1 stop4h 52m

$347

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Fr 7/3

5:40 am-9:21 am

1 stop4h 41m

Gulfport Biloxi Regional

Di 7/7

6:00 pm-11:52 pm

1 stop4h 52m

$352

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Di 6/2

5:50 pm-9:45 pm

1 stop4h 55m

Memphis

Di 6/9

4:15 pm-8:20 pm

1 stop3h 05m

$355

KnoxvilleMobile

TYS - MOB

TYSMOB

Knoxville McGhee Tyson

Fr 7/3

5:40 am-8:35 am

1 stop3h 55m

Mobile

Di 7/7

4:26 pm-9:58 pm

1 stop4h 32m

$357

KnoxvilleMobile

TYS - MOB

TYSMOB

Knoxville McGhee Tyson

Do 5/21

5:40 am-8:25 am

1 stop3h 45m

Mobile

So 5/24

5:10 pm-11:56 pm

1 stop5h 46m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mississippi

What is the cheapest month to book a flight from Knoxville to Mississippi?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $149). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $603). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated April 23, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Mississippi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Knoxville to Mississippi?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Mississippi. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Mississippi?

    For as low as $283, Delta can have you in Mississippi from Knoxville in 4h 18m. The distance between Knoxville and Mississippi is about 341 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Mississippi?

  • Can I find deals for flights from Knoxville to Mississippi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mississippi.

  • Can I find deals for business class flights from Knoxville to Mississippi?

    Yes. Cheapflights offers flight deals from Knoxville to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mississippi?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $149). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $603). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Knoxville to Mississippi

Discover the top 2 airlines that operate flights from Knoxville to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$209Average$442FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$233Average$366FlexibilityNo cancel feeOn-time71%

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