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Knoxville

$79+ Cheap flights from Mississippi to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — TYS
Aug 22 — Aug 291
Sat 8/22
Sat 8/29
1 adult, Economy
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Cheap flight deals from Mississippi to Knoxville

Cheapest flights from Mississippi to Knoxville
Explore the most affordable flight options available from Mississippi to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.

This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:20 pm
MEM
-
TYS
Nonstop1h 12m
Allegiant Air
Fri 10/167:45 pm
TYS
-
MEM
Nonstop1h 19m
Allegiant Air
Deal found 7/19$79
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:57 pm
MEM
-
TYS
Nonstop1h 12m
Allegiant Air
Sun 9/275:38 pm
TYS
-
MEM
Nonstop1h 19m
Allegiant Air
Deal found 7/22$176
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/203:59 pm
MEM
-
TYS
1 stop23h 51m
Allegiant Air
Fri 9/254:48 pm
TYS
-
MEM
Nonstop1h 19m
Allegiant Air
Deal found 7/19$225
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:58 pm
MEM
-
TYS
2 stops37h 06m
Multiple Airlines
Fri 9/254:48 pm
TYS
-
MEM
Nonstop1h 19m
Multiple Airlines
Deal found 7/19$229
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/168:34 am
MEM
-
TYS
1 stop23h 02m
Multiple Airlines
Sun 8/234:52 pm
TYS
-
MEM
2 stops26h 31m
Multiple Airlines
Deal found 7/18$235
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:58 pm
MEM
-
TYS
2 stops37h 06m
Multiple Airlines
Fri 9/254:48 pm
TYS
-
MEM
Nonstop1h 19m
Multiple Airlines
Deal found 7/19$243
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:58 pm
MEM
-
TYS
1 stop21h 07m
Multiple Airlines
Sun 9/275:38 pm
TYS
-
MEM
Nonstop1h 19m
Multiple Airlines
Deal found 7/22$245
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:00 am
JAN
-
TYS
1 stop5h 20m
United Airlines
Tue 8/257:15 am
TYS
-
JAN
1 stop5h 00m
United Airlines
Deal found 7/21$265
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/181:30 pm
JAN
-
TYS
1 stop4h 25m
Southwest
Tue 8/2512:45 pm
TYS
-
JAN
2 stops8h 00m
Southwest
Deal found 7/21$270
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:05 am
JAN
-
TYS
2 stops11h 45m
Southwest
Wed 8/261:55 pm
TYS
-
JAN
2 stops6h 50m
Southwest
Deal found 7/20$275
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:32 am
JAN
-
TYS
1 stop4h 39m
Delta
Wed 8/265:40 am
TYS
-
JAN
1 stop3h 49m
Delta
Deal found 7/20$289
This Delta deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:03 am
BTR
-
TYS
1 stop3h 41m
Delta
Sat 9/125:45 pm
TYS
-
BTR
1 stop4h 04m
Delta
Deal found 7/19$291

Find flight deals from Mississippi to Knoxville

Keep the following information in mind while searching for Mississippi to Knoxville flight deals. Data was last updated July 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$79
(Kiwi.com)

Popular in

June

Cheapest in

December

Average price

$582
Provider with most accurate pricing for Jackson-Evers Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Knoxville McGhee Tyson flights.
Search Deals
From Mississippi to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($98 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Mississippi to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

JacksonKnoxville

JAN - TYS

JANTYS

Jackson-Evers Intl

Wed 8/19

7:05 am-7:50 pm

2 stops11h 45m

Knoxville McGhee Tyson

Wed 8/26

1:55 pm-7:45 pm

2 stops6h 50m

$275
Quickest round-trip

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Sat 8/22

1:40 pm-5:40 pm

1 stop3h 00m

Knoxville McGhee Tyson

Sat 8/29

4:55 pm-7:05 pm

1 stop3h 10m

$275

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Wed 8/19

2:35 pm-6:55 pm

1 stop3h 20m

Knoxville McGhee Tyson

Wed 8/26

7:00 am-9:00 am

1 stop3h 00m

$275

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 8/20

8:15 am-12:20 pm

1 stop3h 05m

Knoxville McGhee Tyson

Mon 8/24

5:45 pm-9:55 pm

1 stop5h 10m

$275

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Wed 8/19

8:15 am-12:05 pm

1 stop2h 50m

Knoxville McGhee Tyson

Sat 8/22

6:50 am-12:00 pm

2 stops6h 10m

$280

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Mon 9/21

5:45 am-1:25 pm

2 stops6h 40m

Knoxville McGhee Tyson

Mon 9/28

5:45 pm-9:55 pm

1 stop5h 10m

$280

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Tue 8/18

7:00 am-2:20 pm

2 stops6h 20m

Knoxville McGhee Tyson

Tue 8/25

1:55 pm-9:45 pm

2 stops8h 50m

$285

JacksonKnoxville

JAN - TYS

JANTYS

Jackson-Evers Intl

Wed 8/19

5:32 am-11:11 am

1 stop4h 39m

Knoxville McGhee Tyson

Wed 8/26

5:40 am-8:29 am

1 stop3h 49m

$289

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Tue 9/8

6:03 am-10:44 am

1 stop3h 41m

Knoxville McGhee Tyson

Tue 9/15

5:40 am-9:39 am

1 stop4h 59m

$291

JacksonKnoxville

JAN - TYS

JANTYS

Jackson-Evers Intl

Fri 9/25

11:08 am-5:40 pm

1 stop5h 32m

Knoxville McGhee Tyson

Mon 9/28

7:25 pm-11:21 pm

1 stop4h 56m

$306

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/22

Showing 1-10 of 52 resultsSorted by cheapest first
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Best time to book a flight from Mississippi to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Knoxville

What is the cheapest month to book a flight from Mississippi to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $288). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $749). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mississippi?

    For a flight from Mississippi to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Mississippi to Knoxville?

    Airlines like Southwest, Delta, and American Airlines fly from Mississippi to Knoxville in about 4h 39m. The time it takes to get you to your destination can typically vary by up to 7h 06m. The distance from Mississippi to Knoxville is about 424 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Mississippi to Knoxville?

    When deciding which route to take from Mississippi to Knoxville consider Baton Rouge Ryan - Knoxville McGhee Tyson, Memphis - Knoxville McGhee Tyson or Gulfport Biloxi Regional - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from Mississippi to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mississippi to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Knoxville.

  • Can I find deals for business class flights from Mississippi to Knoxville?

    Yes. Cheapflights offers flight deals from Mississippi to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $288). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $749). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

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Alternative routes for Mississippi to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to Knoxville

Discover the top 2 airlines that operate flights from Mississippi to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$164Average$486FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$499FlexibilityNo cancel feeOn-time71%

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