$155+ Cheap flights from Mississippi to Knoxville (TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — TYS
Oct 31 — Nov 71
Round-trip
1 adult, Economy
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Find cheap flights from Mississippi to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to Knoxville
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Cheapest flights from Mississippi to KnoxvilleExplore the most affordable flight options available from Mississippi to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 1, 2026.
Explore the most affordable flight options available from Mississippi to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 1, 2026.
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:18 am -
1 stop5h 08m
Sun 11/15:40 am -
1 stop5h 14m
Deal found 9/29![Delta logo]()
$377
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:32 pm -
1 stop4h 16m
Sat 11/75:19 pm -
1 stop6h 22m
Deal found 9/29![American Airlines logo]()
$382
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:42 pm -
1 stop4h 13m
Fri 11/68:04 pm -
1 stop4h 55m
Deal found 9/30![American Airlines logo]()
$397
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1111:45 am -
1 stop7h 45m
Sun 12/138:10 am -
2 stops12h 35m
Deal found 9/27![Southwest logo]()
$399
This Southwest deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:10 pm -
1 stop5h 40m
Tue 11/2412:40 pm -
2 stops10h 45m
Deal found 10/1![Southwest logo]()
$404
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:59 pm -
1 stop6h 19m
Sat 11/72:55 pm -
1 stop49h 34m
Deal found 10/1![American Airlines logo]()
$453
This Kiwi.com deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:46 pm -
1 stop21h 37m
Sun 10/186:40 am -
1 stop13h 25m
Deal found 10/1![Multiple Airlines logo]()
$465
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:04 pm -
1 stop3h 24m
Sat 10/175:40 am -
1 stop5h 14m
Deal found 9/28![Delta logo]()
$467
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:39 pm -
1 stop4h 15m
Sat 10/176:56 am -
1 stop6h 23m
Deal found 9/28![American Airlines logo]()
$477
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:40 am -
2 stops12h 30m
Sat 10/171:30 pm -
2 stops6h 30m
Deal found 9/28![Southwest logo]()
$477
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/103:33 pm -
1 stop3h 35m
Wed 10/145:40 am -
1 stop3h 53m
Deal found 9/26![Delta logo]()
$493
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:25 am -
1 stop5h 30m
Wed 10/147:15 am -
2 stops13h 45m
Deal found 9/26![Southwest logo]()
$498
Best flights from Mississippi to KnoxvilleDiscover carefully curated flight deals from Mississippi to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 1, 2026.
Discover carefully curated flight deals from Mississippi to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 1, 2026.
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:18 am -
1 stop5h 08m
Sun 11/15:40 am -
1 stop5h 14m
Deal found 9/29![Delta logo]()
$377
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/301:54 pm -
1 stop7h 20m
Wed 2/37:00 am -
1 stop7h 26m
Deal found 9/30![United Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:59 pm -
1 stop6h 19m
Sat 11/72:55 pm -
1 stop49h 34m
Deal found 10/1![American Airlines logo]()
$453
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:40 am -
2 stops9h 00m
Sat 10/176:40 am -
1 stop9h 05m
Deal found 9/28![Southwest logo]()
$498
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:39 pm -
1 stop4h 15m
Sat 10/176:56 am -
1 stop6h 23m
Deal found 9/28![American Airlines logo]()
$477
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/103:33 pm -
1 stop3h 35m
Wed 10/145:40 am -
1 stop3h 53m
Deal found 9/26![Delta logo]()
$493
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/187:29 pm -
1 stop3h 30m
Sun 10/255:40 am -
1 stop3h 53m
Deal found 9/27![Delta logo]()
$519
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:15 am -
2 stops10h 40m
Wed 10/147:15 am -
2 stops13h 45m
Deal found 9/26![Southwest logo]()
$579
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:21 pm -
1 stop5h 23m
Tue 11/246:50 am -
1 stop4h 32m
Deal found 10/1![American Airlines logo]()
$535
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/189:20 am -
1 stop7h 45m
Thu 10/297:00 am -
1 stop5h 15m
Deal found 10/1![United Airlines logo]()
$616
This Southwest deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1812:55 pm -
1 stop8h 50m
Thu 10/2912:50 pm -
2 stops10h 05m
Deal found 10/1![Southwest logo]()
$584
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:06 pm -
1 stop4h 06m
Sun 11/295:40 am -
1 stop3h 51m
Deal found 9/27![Delta logo]()
$533
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:43 pm -
1 stop3h 54m
Mon 11/97:14 pm -
1 stop4h 27m
Deal found 9/29![American Airlines logo]()
$538
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/31:54 pm -
1 stop7h 03m
Sat 11/75:40 pm -
2 stops20h 38m
Deal found 9/29![United Airlines logo]()
$623
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:42 pm -
1 stop4h 13m
Mon 10/197:58 pm -
1 stop5h 01m
Deal found 10/1![American Airlines logo]()
$567
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:00 pm -
2 stops8h 35m
Tue 10/208:20 am -
2 stops10h 40m
Deal found 9/30![Southwest logo]()
$658
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:59 pm -
1 stop21h 06m
Mon 11/95:32 pm -
1 stop22h 57m
Deal found 10/1![American Airlines logo]()
$583
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/132:00 pm -
1 stop6h 55m
Sat 10/176:00 am -
2 stops14h 38m
Deal found 9/28![United Airlines logo]()
$709
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1412:55 pm -
1 stop7h 10m
Sun 10/187:15 am -
2 stops13h 30m
Deal found 9/29![Southwest logo]()
$683
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:59 pm -
1 stop6h 19m
Tue 10/203:00 pm -
1 stop25h 29m
Deal found 10/1![American Airlines logo]()
$741
Last-minute flights from Mississippi to KnoxvilleDiscover last-minute flight deals from Mississippi to Knoxville. Data last updated October 1, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to Knoxville. Data last updated October 1, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:00 pm -
1 stop5h 05m
Mon 10/53:45 pm -
1 stop4h 53m
Deal found 9/30![United Airlines logo]()
$499
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/103:33 pm -
1 stop3h 35m
Wed 10/145:40 am -
1 stop3h 53m
Deal found 9/26![Delta logo]()
$493
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:25 am -
1 stop5h 30m
Wed 10/147:15 am -
2 stops13h 45m
Deal found 9/26![Southwest logo]()
$498
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:04 pm -
1 stop3h 24m
Sat 10/175:40 am -
1 stop5h 14m
Deal found 9/28![Delta logo]()
$467
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:39 pm -
1 stop4h 15m
Sat 10/176:56 am -
1 stop6h 23m
Deal found 9/28![American Airlines logo]()
$477
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:40 am -
2 stops12h 30m
Sat 10/171:30 pm -
2 stops6h 30m
Deal found 9/28![Southwest logo]()
$477
This Kiwi.com deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:46 pm -
1 stop21h 37m
Sun 10/186:40 am -
1 stop13h 25m
Deal found 10/1![Multiple Airlines logo]()
$465
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:18 am -
1 stop5h 08m
Sun 11/15:40 am -
1 stop5h 14m
Deal found 9/29![Delta logo]()
$377
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:42 pm -
1 stop4h 13m
Fri 11/68:04 pm -
1 stop4h 55m
Deal found 9/30![American Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:59 pm -
1 stop6h 19m
Sat 11/72:55 pm -
1 stop49h 34m
Deal found 10/1![American Airlines logo]()
$453
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:32 pm -
1 stop4h 16m
Sat 11/75:19 pm -
1 stop6h 22m
Deal found 9/29![American Airlines logo]()
$382
This Southwest deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:10 pm -
1 stop5h 40m
Tue 11/2412:40 pm -
2 stops10h 45m
Deal found 10/1![Southwest logo]()
$404
One-way flights from Mississippi to KnoxvilleSearch for one-way flight options from Mississippi to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 1, 2026.
Search for one-way flight options from Mississippi to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:46 pm -
2 stops14h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Multiple Airlines logo]()
$155
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/275:40 am -
2 stops8h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Southwest logo]()
$171
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:26 am -
1 stop3h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Delta logo]()
$202
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/231:46 pm -
1 stop4h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Delta logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:45 pm -
1 stop14h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$222
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:35 pm -
1 stop6h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Southwest logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:46 pm -
3 stops51h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Multiple Airlines logo]()
$288
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:45 am -
1 stop4h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![American Airlines logo]()
$299
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:40 am -
2 stops9h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![Southwest logo]()
$304
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:05 pm -
1 stop4h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Delta logo]()
$333
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:15 am -
2 stops7h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Southwest logo]()
$354
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:51 am -
2 stops11h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/26![American Airlines logo]()
$404
Find flight deals from Mississippi to Knoxville
Keep the following information in mind while searching for Mississippi to Knoxville flight deals. Data was last updated October 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $377 (Delta) |
One-way from | $155 (Kiwi.com) |
Popular in | June |
Cheapest in | September |
Average price | $582 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 1, 2026.
Use the filters below to find and compare flights from Mississippi to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GulfportKnoxville
GPT Gulfport Biloxi Regional - TYS Knoxville McGhee Tyson
GPTTYS
Gulfport Biloxi Regional
Fri 10/23
6:46 pm-9:44 am
3 stops37h 58m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$161
JacksonKnoxville
JAN Jackson-Evers Intl - TYS Knoxville McGhee Tyson
JANTYS
Jackson-Evers Intl
Fri 11/27
5:40 am-3:00 pm
2 stops8h 20m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$171
Quickest round-trip
GulfportKnoxville
GPT Gulfport Biloxi Regional - TYS Knoxville McGhee Tyson
GPTTYS
Gulfport Biloxi Regional
Sat 10/24
6:26 am-10:53 am
1 stop3h 27m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$202
GulfportKnoxville
GPT Gulfport Biloxi Regional - TYS Knoxville McGhee Tyson
GPTTYS
Gulfport Biloxi Regional
Fri 10/23
1:46 pm-7:42 pm
1 stop4h 56m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$213
GulfportKnoxville
GPT Gulfport Biloxi Regional - TYS Knoxville McGhee Tyson
GPTTYS
Gulfport Biloxi Regional
Sun 10/11
7:45 pm-11:14 am
1 stop14h 29m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$222
JacksonKnoxville
JAN Jackson-Evers Intl - TYS Knoxville McGhee Tyson
JANTYS
Jackson-Evers Intl
Sat 11/21
3:35 pm-10:45 pm
1 stop6h 10m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$274
GulfportKnoxville
GPT Gulfport Biloxi Regional - TYS Knoxville McGhee Tyson
GPTTYS
Gulfport Biloxi Regional
Fri 10/9
6:46 pm-11:30 pm
3 stops51h 44m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$288
JacksonKnoxville
JAN Jackson-Evers Intl - TYS Knoxville McGhee Tyson
JANTYS
Jackson-Evers Intl
Tue 10/6
7:45 am-1:33 pm
1 stop4h 48m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$299
JacksonKnoxville
JAN Jackson-Evers Intl - TYS Knoxville McGhee Tyson
JANTYS
Jackson-Evers Intl
Wed 10/7
7:45 am-1:40 pm
1 stop4h 55m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$299
JacksonKnoxville
JAN Jackson-Evers Intl - TYS Knoxville McGhee Tyson
JANTYS
Jackson-Evers Intl
Sat 10/10
11:25 am-5:55 pm
1 stop5h 30m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$299
Showing 1-10 of 37 resultsSorted by cheapest first
Best time to book a flight from Mississippi to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mississippi with our price prediction graph.
GPT-TYS
JAN-TYS
GTR-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to Knoxville
USMS-TYS
GPT-TYS
JAN-TYS
GTR-TYS
What is the cheapest month to book a flight from Mississippi to Knoxville?
Currently, November is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $366). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $749). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Mississippi to Knoxville
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Complete your trip
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 1, 2026.
Mississippi and Knoxville flights
Browse other Mississippi and Knoxville flight options. Last updated on October 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Mississippi to Knoxville flights
Consider these flights traveling from Mississippi to Knoxville.
Top airline flying from Mississippi to Knoxville
Discover the top airline that operate flights from Mississippi to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$178 | Average$467 | FlexibilityNo cancel fee | On-timeN/A |