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Knoxville

$99+ Cheap flights from Mississippi to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — TYS
May 13 — May 201
Wed 5/13
Wed 5/20
1 adult, Economy
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Cheap flight deals from Mississippi to Knoxville

Cheapest flights from Mississippi to Knoxville
Explore the most affordable flight options available from Mississippi to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 13, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:22 pm
MEM
-
TYS
Nonstop1h 12m
Allegiant Air
Sun 10/46:11 pm
TYS
-
MEM
Nonstop1h 19m
Allegiant Air
Deal found 4/7$102
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:05 am
MEM
-
TYS
1 stop13h 19m
Multiple Airlines
Fri 5/151:15 pm
TYS
-
MEM
1 stop28h 17m
Multiple Airlines
Deal found 4/9$213
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/268:35 pm
MEM
-
TYS
1 stop24h 13m
Allegiant Air
Thu 4/309:25 pm
TYS
-
MEM
1 stop21h 24m
Allegiant Air
Deal found 4/11$219
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/188:05 am
MEM
-
TYS
1 stop13h 19m
Allegiant Air
Wed 5/202:20 pm
TYS
-
MEM
1 stop18h 12m
Allegiant Air
Deal found 4/9$231
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:05 am
MEM
-
TYS
1 stop13h 19m
Multiple Airlines
Fri 5/81:15 pm
TYS
-
MEM
1 stop28h 17m
Multiple Airlines
Deal found 4/10$237
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:05 am
MEM
-
TYS
1 stop13h 19m
Multiple Airlines
Mon 5/116:20 pm
TYS
-
MEM
1 stop23h 12m
Multiple Airlines
Deal found 4/10$238
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:05 am
MEM
-
TYS
1 stop13h 19m
Allegiant Air
Fri 5/17:30 am
TYS
-
MEM
1 stop11h 19m
Allegiant Air
Deal found 4/12$243
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:05 am
MEM
-
TYS
1 stop13h 19m
Allegiant Air
Thu 5/79:40 pm
TYS
-
MEM
1 stop21h 09m
Allegiant Air
Deal found 4/10$248
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/28:40 pm
MEM
-
TYS
1 stop25h 39m
Allegiant Air
Sun 7/122:08 pm
TYS
-
MEM
1 stop18h 41m
Allegiant Air
Deal found 4/12$249
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:05 am
MEM
-
TYS
1 stop13h 19m
Allegiant Air
Sun 5/101:14 pm
TYS
-
MEM
1 stop6h 01m
Allegiant Air
Deal found 4/11$265
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:50 pm
GPT
-
TYS
1 stop25h 34m
Multiple Airlines
Sun 5/174:31 pm
TYS
-
GPT
1 stop16h 10m
Multiple Airlines
Deal found 4/8$299
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/24:00 pm
BTR
-
TYS
1 stop4h 58m
Delta
Sat 8/86:00 am
TYS
-
BTR
1 stop4h 39m
Delta
Deal found 4/13$323

Find flight deals from Mississippi to Knoxville

Keep the following information in mind while searching for Mississippi to Knoxville flight deals. Data was last updated April 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$213
(Kiwi.com)

One-way from

$99
(Kiwi.com)

Popular in

November

Cheapest in

April

Average price

$233
Provider with most accurate pricing for Jackson-Evers Intl-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Knoxville McGhee Tyson flights.
Search Deals
From Mississippi to Knoxville McGhee Tyson
Search Deals
One-way flight from Mississippi to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($119 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 13, 2026.
Use the filters below to find and compare flights from Mississippi to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 5/14

5:37 pm-5:30 pm

1 stop22h 53m

Knoxville McGhee Tyson

Thu 5/21

7:15 am-7:34 am

1 stop25h 19m

$269

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Mon 5/18

7:45 am-11:40 am

1 stop2h 55m

Knoxville McGhee Tyson

Wed 5/20

12:50 pm-9:45 pm

2 stops9h 55m

$314

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Sun 8/2

4:00 pm-9:58 pm

1 stop4h 58m

Knoxville McGhee Tyson

Sat 8/8

6:00 am-9:39 am

1 stop4h 39m

$323

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Tue 6/30

4:15 pm-8:20 pm

1 stop3h 05m

Knoxville McGhee Tyson

Sat 7/4

12:30 pm-5:05 pm

1 stop5h 35m

$326
Quickest round-trip

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 8/27

2:55 pm-6:35 pm

1 stop2h 40m

Knoxville McGhee Tyson

Sun 8/30

7:35 am-9:45 am

1 stop3h 10m

$357

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Sat 8/29

12:10 pm-6:05 pm

1 stop4h 55m

Knoxville McGhee Tyson

Wed 9/2

7:15 am-1:15 pm

1 stop7h 00m

$371

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Sat 5/2

4:55 pm-11:44 pm

1 stop5h 49m

Knoxville McGhee Tyson

Sat 5/9

11:40 am-4:13 pm

1 stop5h 33m

$379

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Sat 8/29

2:00 pm-9:30 pm

1 stop6h 30m

Knoxville McGhee Tyson

Wed 9/2

7:15 am-1:26 pm

1 stop7h 11m

$384

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Sat 8/22

2:00 pm-9:30 pm

1 stop6h 30m

Knoxville McGhee Tyson

Tue 8/25

7:15 am-1:26 pm

1 stop7h 11m

$384

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Wed 5/6

9:45 am-7:40 pm

2 stops8h 55m

Knoxville McGhee Tyson

Fri 5/8

6:35 am-3:50 pm

2 stops10h 15m

$404

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/12

Showing 1-10 of 51 resultsSorted by cheapest first
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Best time to book a flight from Mississippi to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Knoxville

What is the cheapest month to book a flight from Mississippi to Knoxville?

Currently, August is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $149). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $430). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mississippi?

    For a flight from Mississippi to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Mississippi to Knoxville?

    Airlines like Southwest, Delta, and United Airlines fly from Mississippi to Knoxville in about 2h 55m. The time it takes to get you to your destination can typically vary by up to 2h 03m. The distance from Mississippi to Knoxville is about 341 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Mississippi to Knoxville?

    When deciding which route to take from Mississippi to Knoxville consider Memphis - Knoxville McGhee Tyson, Baton Rouge Ryan - Knoxville McGhee Tyson or Jackson-Evers Intl - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from Mississippi to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mississippi to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Knoxville.

  • Can I find deals for business class flights from Mississippi to Knoxville?

    Yes. Cheapflights offers flight deals from Mississippi to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Knoxville?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $149). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $430). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mississippi to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to Knoxville

Discover the top 2 airlines that operate flights from Mississippi to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$164Average$495FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$465FlexibilityNo cancel feeOn-time71%

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