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$356+ Cheap flights from Missoula to Knoxville (MSO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/18. Fares are subject to change and may not be available on all flights or dates of travel.
MSO — TYS
Apr 1 — Apr 81
Wed 4/1
Wed 4/8
1 adult, Economy
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Cheap flight deals from Missoula to Knoxville

Cheapest flights from Missoula to Knoxville
Explore the most affordable flight options available from Missoula to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 2, 2026.

This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:15 am
MSO
-
TYS
1 stop6h 21m
United Airlines
Sat 10/314:25 pm
TYS
-
MSO
1 stop7h 01m
United Airlines
Deal found 3/1$399
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/92:08 pm
MSO
-
TYS
1 stop7h 45m
American Airlines
Tue 6/167:09 am
TYS
-
MSO
1 stop7h 25m
American Airlines
Deal found 2/27$436
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:15 am
MSO
-
TYS
1 stop7h 39m
United Airlines
Sat 11/218:45 am
TYS
-
MSO
1 stop9h 25m
United Airlines
Deal found 2/26$447
This Alaska Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:36 pm
MSO
-
TYS
2 stops16h 36m
Alaska Airlines
Sat 11/212:59 pm
TYS
-
MSO
2 stops11h 00m
Alaska Airlines
Deal found 2/26$479
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:08 pm
MSO
-
TYS
1 stop20h 10m
American Airlines
Mon 5/48:48 pm
TYS
-
MSO
1 stop17h 50m
American Airlines
Deal found 2/27$483
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:45 am
MSO
-
TYS
1 stop9h 19m
American Airlines
Tue 5/267:09 am
TYS
-
MSO
1 stop7h 25m
American Airlines
Deal found 2/27$493
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:08 pm
MSO
-
TYS
1 stop20h 10m
American Airlines
Sun 4/268:48 pm
TYS
-
MSO
1 stop17h 50m
American Airlines
Deal found 3/1$511

Find flight deals from Missoula to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Missoula (MSO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 2, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$436
(American Airlines)

One-way from

$356
(Alaska Airlines)

Popular in

May

Cheapest in

August

Average price

$649
Provider with most accurate pricing for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Missoula Johnson-Bell Field-Knoxville McGhee Tyson flights.
Search Deals
From Missoula Johnson-Bell Field to Knoxville McGhee Tyson
Search Deals
One-way flight from Missoula Johnson-Bell Field to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 26% potential increase in price ($228 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($61 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missoula to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 2, 2026.
Use the filters below to find and compare flights from Missoula to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Fri 4/24

1:08 pm-11:18 am

1 stop20h 10m

Knoxville McGhee Tyson

Sun 4/26

8:48 pm-12:38 pm

1 stop17h 50m

$511

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 5/19

6:15 am-8:45 pm

2 stops12h 30m

Knoxville McGhee Tyson

Tue 5/26

6:30 am-11:32 am

1 stop7h 02m

$516

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 6/9

8:02 pm-10:58 am

2 stops12h 56m

Knoxville McGhee Tyson

Tue 6/16

5:33 pm-10:42 am

2 stops19h 09m

$569

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 4/30

1:08 pm-9:21 pm

1 stop6h 13m

Knoxville McGhee Tyson

Sun 5/3

7:50 am-12:38 pm

1 stop6h 48m

$576

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 4/30

1:08 pm-9:21 pm

1 stop6h 13m

Knoxville McGhee Tyson

Mon 5/4

8:48 pm-12:38 pm

1 stop17h 50m

$582

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Tue 5/19

8:02 pm-1:15 pm

2 stops15h 13m

Knoxville McGhee Tyson

Tue 5/26

1:53 pm-11:59 pm

2 stops12h 06m

$596

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Fri 5/1

5:08 pm-10:23 pm

1 stop27h 15m

Knoxville McGhee Tyson

Mon 5/4

6:01 pm-1:35 pm

2 stops21h 34m

$607

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 4/30

5:08 pm-4:49 pm

2 stops21h 41m

Knoxville McGhee Tyson

Mon 5/4

6:01 pm-1:35 pm

2 stops21h 34m

$607

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Thu 4/23

6:15 am-3:06 pm

1 stop6h 51m

Knoxville McGhee Tyson

Mon 4/27

7:00 am-4:06 pm

2 stops11h 06m

$610

MissoulaKnoxville

MSO - TYS

MSOTYS

Missoula Johnson-Bell Field

Sat 7/18

7:59 pm-11:13 am

2 stops13h 14m

$356

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/27

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Compare providers for flights from Missoula to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Missoula to Knoxville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Missoula-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Missoula-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Missoula-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Missoula-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Missoula-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Missoula to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missoula with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 2, 2026.
Read through reviews of airlines operating flights from Missoula to Knoxville, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,375 reviews

Boarding

7.7

Food

6.6

Crew

8.1

Comfort

7.3

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,375 reviews
United Airlines
7.4
Good
9,375 reviews

Boarding

7.7

Food

6.6

Crew

8.1

Comfort

7.3

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
American Airlines
7.1
Good
11,369 reviews
United Airlines
7.4
Good
9,375 reviews

Boarding

7.7

Food

6.6

Crew

8.1

Comfort

7.3

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Missoula to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missoula to Knoxville?

    Airlines like American Airlines, United Airlines, and Alaska Airlines fly from Missoula to Knoxville in about 12h 30m. The time it takes to get you to your destination can typically vary by up to 7h 40m. There are 1724 mi between Missoula and Knoxville. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Missoula to Knoxville round-trip?

    Currently priced at $288, American Airlines will fly you from Missoula to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on United Airlines for as low as $343. These flights start at 53% lower than the current average price 3 months from now.

  • Can I find deals for flights from Missoula to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missoula to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missoula to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missoula to Knoxville.

  • Can I find deals for business class flights from Missoula to Knoxville?

    Yes. Cheapflights offers flight deals from Missoula to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Missoula to Knoxville

Discover the top 2 airlines that operate flights from Missoula to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$288Average$453FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$343Average$599FlexibilityNo cancel feeOn-time69%

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