$101+ Cheap flights from Des Moines to Knoxville (DSM - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Jul 14 — Jul 211
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to KnoxvilleExplore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 14, 2026.
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:08 pm
DSM
- TYS
1 stop27h 52m
Allegiant Air
Thu 7/163:38 pm
TYS
- DSM
1 stop6h 49m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/712:37 pm
DSM
- TYS
1 stop9h 35m
Allegiant Air
Sun 8/92:56 pm
TYS
- DSM
1 stop7h 35m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:08 pm
DSM
- TYS
1 stop27h 52m
Multiple Airlines
Thu 7/167:15 am
TYS
- DSM
2 stops15h 12m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$252
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:45 pm
DSM
- TYS
1 stop4h 05m
Delta
Sat 9/1911:30 am
TYS
- DSM
1 stop4h 45m
Delta
Deal found 6/9![Delta logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Thu 6/254:05 pm
TYS
- DSM
1 stop6h 42m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- TYS
1 stop6h 37m
Allegiant Air
Fri 7/1010:05 pm
TYS
- DSM
1 stop19h 04m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1210:57 am
DSM
- TYS
1 stop24h 06m
Allegiant Air
Fri 7/177:04 pm
TYS
- DSM
1 stop27h 39m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/114:59 pm
DSM
- TYS
1 stop29h 04m
Allegiant Air
Sat 7/1812:54 pm
TYS
- DSM
1 stop9h 49m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$297
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/203:53 pm
DSM
- TYS
1 stop5h 03m
American Airlines
Sat 10/245:37 pm
TYS
- DSM
1 stop6h 30m
American Airlines
Deal found 6/12![American Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/255:02 pm
DSM
- TYS
1 stop27h 48m
Allegiant Air
Sun 6/284:05 pm
TYS
- DSM
1 stop7h 47m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$303
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:24 pm
DSM
- TYS
2 stops9h 35m
United Airlines
Sat 10/2410:42 am
TYS
- DSM
1 stop4h 33m
United Airlines
Deal found 6/12![United Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- TYS
1 stop22h 30m
Allegiant Air
Fri 7/1010:05 pm
TYS
- DSM
1 stop19h 04m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$306
Best flights from Des Moines to KnoxvilleDiscover carefully curated flight deals from Des Moines to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 14, 2026.
Discover carefully curated flight deals from Des Moines to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 14, 2026.
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:24 pm
DSM
- TYS
2 stops9h 35m
United Airlines
Sat 10/2410:42 am
TYS
- DSM
1 stop4h 33m
United Airlines
Deal found 6/12![United Airlines logo]()
$304
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:37 pm
DSM
- TYS
1 stop7h 21m
American Airlines
Wed 7/86:32 pm
TYS
- DSM
1 stop6h 29m
American Airlines
Deal found 6/9![American Airlines logo]()
$307
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:35 pm
DSM
- TYS
1 stop4h 17m
Delta
Sun 8/236:35 am
TYS
- DSM
1 stop4h 43m
Delta
Deal found 6/9![Delta logo]()
$318
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:35 am
DSM
- TYS
2 stops10h 10m
Southwest
Mon 10/512:50 pm
TYS
- DSM
2 stops11h 40m
Southwest
Deal found 6/10![Southwest logo]()
$335
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:30 pm
DSM
- TYS
1 stop4h 16m
Delta
Mon 10/265:30 am
TYS
- DSM
1 stop5h 48m
Delta
Deal found 6/12![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/13:24 pm
DSM
- TYS
1 stop4h 20m
United Airlines
Wed 7/810:00 am
TYS
- DSM
2 stops12h 22m
United Airlines
Deal found 6/9![United Airlines logo]()
$332
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am
DSM
- TYS
2 stops10h 30m
Southwest
Sat 10/247:00 am
TYS
- DSM
2 stops13h 40m
Southwest
Deal found 6/12![Southwest logo]()
$341
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/183:22 pm
DSM
- TYS
1 stop5h 11m
American Airlines
Sat 7/256:22 am
TYS
- DSM
1 stop7h 41m
American Airlines
Deal found 6/11![American Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/212:41 pm
DSM
- TYS
1 stop7h 23m
Delta
Fri 9/256:35 am
TYS
- DSM
1 stop4h 42m
Delta
Deal found 6/13![Delta logo]()
$338
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:29 am
DSM
- TYS
2 stops7h 08m
United Airlines
Fri 9/256:00 am
TYS
- DSM
1 stop5h 31m
United Airlines
Deal found 6/13![United Airlines logo]()
$343
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:40 am
DSM
- TYS
2 stops10h 30m
Southwest
Fri 9/253:15 pm
TYS
- DSM
2 stops7h 55m
Southwest
Deal found 6/13![Southwest logo]()
$367
Last-minute flights from Des Moines to KnoxvilleDiscover last-minute flight deals from Des Moines to Knoxville. Data last updated June 14, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Knoxville. Data last updated June 14, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:02 pm
DSM
- TYS
1 stop27h 48m
Allegiant Air
Thu 6/254:05 pm
TYS
- DSM
1 stop6h 42m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:00 am
DSM
- TYS
1 stop15h 53m
Allegiant Air
Thu 6/254:05 pm
TYS
- DSM
1 stop6h 42m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Thu 6/254:05 pm
TYS
- DSM
1 stop6h 42m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/255:02 pm
DSM
- TYS
1 stop27h 48m
Allegiant Air
Sun 6/284:05 pm
TYS
- DSM
1 stop7h 47m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$303
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:37 pm
DSM
- TYS
1 stop7h 21m
American Airlines
Tue 7/76:32 pm
TYS
- DSM
1 stop6h 29m
American Airlines
Deal found 6/10![American Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- TYS
1 stop6h 37m
Allegiant Air
Fri 7/1010:05 pm
TYS
- DSM
1 stop19h 04m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- TYS
1 stop22h 30m
Allegiant Air
Fri 7/1010:05 pm
TYS
- DSM
1 stop19h 04m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:08 pm
DSM
- TYS
1 stop27h 52m
Allegiant Air
Thu 7/163:38 pm
TYS
- DSM
1 stop6h 49m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:08 pm
DSM
- TYS
1 stop27h 52m
Multiple Airlines
Thu 7/167:15 am
TYS
- DSM
2 stops15h 12m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/114:59 pm
DSM
- TYS
1 stop29h 04m
Allegiant Air
Sat 7/1812:54 pm
TYS
- DSM
1 stop9h 49m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1210:57 am
DSM
- TYS
1 stop24h 06m
Allegiant Air
Fri 7/177:04 pm
TYS
- DSM
1 stop27h 39m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:40 pm
DSM
- TYS
1 stop14h 52m
Allegiant Air
Sun 7/193:38 pm
TYS
- DSM
1 stop8h 09m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$322
One-way flights from Des Moines to KnoxvilleSearch for one-way flight options from Des Moines to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 14, 2026.
Search for one-way flight options from Des Moines to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1012:37 pm
DSM
- TYS
1 stop9h 35m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/271:37 pm
DSM
- TYS
1 stop8h 11m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1012:37 pm
DSM
- TYS
2 stops52h 51m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$178
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/232:22 pm
DSM
- TYS
1 stop6h 11m
American Airlines
Deal found 6/11![American Airlines logo]()
$179
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/275:10 am
DSM
- TYS
2 stops15h 05m
Southwest
Deal found 6/10![Southwest logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:00 am
DSM
- TYS
1 stop15h 53m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:00 am
DSM
- TYS
1 stop15h 53m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2710:01 pm
DSM
- TYS
3 stops42h 58m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/219:27 am
DSM
- TYS
1 stop12h 20m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/232:54 pm
DSM
- TYS
1 stop21h 35m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$284
Find flight deals from Des Moines to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $193 (Kiwi.com) |
One-way from | $101 (Kiwi.com) |
Popular in | September |
Cheapest in | November |
Average price | $370 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 14, 2026.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Tue 10/20
1:24 pm-11:59 pm
2 stops9h 35m
Knoxville McGhee Tyson
Sat 10/24
10:42 am-2:15 pm
1 stop4h 33m
$304
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Wed 7/1
1:37 pm-9:58 pm
1 stop7h 21m
Knoxville McGhee Tyson
Wed 7/8
6:32 pm-12:01 am
1 stop6h 29m
$307
Quickest round-trip
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Thu 8/20
6:35 pm-11:52 pm
1 stop4h 17m
Knoxville McGhee Tyson
Sun 8/23
6:35 am-10:18 am
1 stop4h 43m
$318
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Mon 10/19
6:30 pm-11:46 pm
1 stop4h 16m
Knoxville McGhee Tyson
Mon 10/26
5:30 am-10:18 am
1 stop5h 48m
$319
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Wed 7/1
3:24 pm-8:44 pm
1 stop4h 20m
Knoxville McGhee Tyson
Wed 7/8
10:00 am-9:22 pm
2 stops12h 22m
$332
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Thu 10/1
5:35 am-4:45 pm
2 stops10h 10m
Knoxville McGhee Tyson
Mon 10/5
12:50 pm-11:30 pm
2 stops11h 40m
$335
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Mon 9/21
2:41 pm-11:04 pm
1 stop7h 23m
Knoxville McGhee Tyson
Fri 9/25
6:35 am-10:17 am
1 stop4h 42m
$338
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Tue 10/20
7:00 am-6:30 pm
2 stops10h 30m
Knoxville McGhee Tyson
Sat 10/24
7:00 am-7:40 pm
2 stops13h 40m
$341
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Mon 9/21
6:29 am-2:37 pm
2 stops7h 08m
Knoxville McGhee Tyson
Fri 9/25
6:00 am-10:31 am
1 stop5h 31m
$343
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Sat 7/18
3:22 pm-9:33 pm
1 stop5h 11m
Knoxville McGhee Tyson
Sat 7/25
6:22 am-1:03 pm
1 stop7h 41m
$357
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Knoxville in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.
DSM-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 14, 2026.
Read through reviews of airlines operating flights from Des Moines to Knoxville, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Entertainment
7.8
Food
7.2
Overall
7.9
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Entertainment
7.8
Food
7.2
Overall
7.9
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Entertainment
7.8
Food
7.2
Overall
7.9
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Entertainment
7.8
Food
7.2
Overall
7.9
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
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Other flights to Knoxville
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Des Moines and Knoxville flights
Browse other Des Moines and Knoxville flight options. Last updated on June 14, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on June 14, 2026.
Popular flight searches
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Top 3 airlines flying from Des Moines to Knoxville
Discover the top 3 airlines that operate flights from Des Moines to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$203 | Average$349 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$203 | Average$356 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$299 | Average$387 | FlexibilityNo cancel fee | On-time69% |