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$132+ Cheap flights from Des Moines to Knoxville (DSM - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/18. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Aug 25 — Sep 11
Tue 8/25
Tue 9/1
1 adult, Economy
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Cheap flight deals from Des Moines to Knoxville

Cheapest flights from Des Moines to Knoxville
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 26, 2026.

This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:40 am
DSM
-
TYS
1 stop4h 31m
Delta
Sat 8/227:30 am
TYS
-
DSM
1 stop4h 13m
Delta
Deal found 7/23$279
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2211:32 am
DSM
-
TYS
1 stop4h 26m
United Airlines
Sat 8/295:45 am
TYS
-
DSM
2 stops9h 31m
United Airlines
Deal found 7/23$284
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/231:55 pm
DSM
-
TYS
1 stop27h 40m
Allegiant Air
Sun 8/301:21 pm
TYS
-
DSM
1 stop28h 17m
Allegiant Air
Deal found 7/24$286
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:15 am
DSM
-
TYS
1 stop6h 05m
United Airlines
Sat 8/296:02 pm
TYS
-
DSM
1 stop4h 21m
United Airlines
Deal found 7/25$287
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:12 pm
DSM
-
TYS
1 stop28h 12m
Multiple Airlines
Fri 8/212:51 pm
TYS
-
DSM
2 stops42h 47m
Multiple Airlines
Deal found 7/23$288
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:12 pm
DSM
-
TYS
1 stop28h 12m
Allegiant Air
Sun 8/162:56 pm
TYS
-
DSM
1 stop7h 35m
Allegiant Air
Deal found 7/23$289
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:10 am
DSM
-
TYS
2 stops7h 10m
Southwest
Sat 8/296:50 am
TYS
-
DSM
2 stops8h 20m
Southwest
Deal found 7/25$297
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:24 am
DSM
-
TYS
2 stops7h 13m
United Airlines
Sat 9/195:45 am
TYS
-
DSM
2 stops9h 35m
United Airlines
Deal found 7/24$298
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:12 pm
DSM
-
TYS
1 stop28h 12m
Multiple Airlines
Thu 8/202:39 pm
TYS
-
DSM
2 stops29h 09m
Multiple Airlines
Deal found 7/23$305
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:48 am
DSM
-
TYS
1 stop23h 43m
Allegiant Air
Sat 8/1512:54 pm
TYS
-
DSM
2 stops22h 15m
Allegiant Air
Deal found 7/23$312
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/112:54 pm
DSM
-
TYS
1 stop4h 16m
Delta
Wed 8/196:35 am
TYS
-
DSM
1 stop4h 43m
Delta
Deal found 7/23$314

Find flight deals from Des Moines to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(Delta)

One-way from

$132
(Kiwi.com)

Popular in

September

Cheapest in

November

Average price

$408
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
Search Deals
From Des Moines to Knoxville McGhee Tyson
Search Deals
One-way flight from Des Moines to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($115 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 26, 2026.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 8/31

3:02 pm-9:45 pm

1 stop5h 43m

Knoxville McGhee Tyson

Wed 9/2

1:00 pm-9:23 pm

2 stops9h 23m

$284

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 8/25

6:15 am-1:20 pm

1 stop6h 05m

Knoxville McGhee Tyson

Sat 8/29

6:02 pm-9:23 pm

1 stop4h 21m

$287

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 8/22

7:20 am-5:40 pm

2 stops9h 20m

Knoxville McGhee Tyson

Sat 8/29

6:50 am-2:10 pm

2 stops8h 20m

$289

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 8/31

5:40 am-12:20 pm

2 stops5h 40m

Knoxville McGhee Tyson

Wed 9/2

12:45 pm-9:55 pm

2 stops10h 10m

$289

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 9/12

11:32 am-8:24 pm

2 stops7h 52m

Knoxville McGhee Tyson

Sat 9/19

4:50 pm-11:33 pm

1 stop7h 43m

$292

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 10/21

1:24 pm-8:49 pm

1 stop6h 25m

Knoxville McGhee Tyson

Wed 10/28

9:58 am-5:23 pm

2 stops8h 25m

$292

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 9/16

11:32 am-4:58 pm

1 stop4h 26m

Knoxville McGhee Tyson

Sun 9/20

6:00 am-10:31 am

1 stop5h 31m

$327
Quickest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 9/4

5:56 pm-11:00 pm

1 stop4h 04m

Knoxville McGhee Tyson

Fri 9/11

6:30 am-10:17 am

1 stop4h 47m

$328

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 8/25

6:10 am-2:20 pm

2 stops7h 10m

Knoxville McGhee Tyson

Fri 8/28

5:45 pm-10:10 pm

2 stops5h 25m

$328

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 8/21

6:55 am-12:51 pm

1 stop4h 56m

Knoxville McGhee Tyson

Sun 8/23

6:21 pm-11:44 pm

1 stop6h 23m

$357

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/21

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Knoxville in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Knoxville

How much does it cost to fly round-trip from Des Moines to Knoxville?

Airfare is below average for this route at the moment.

Des Moines to Knoxville flights typically cost between $326 and $464 in August.
The cheapest round-trip price found within the last 5 days was $279 on Delta (Aug 13-Aug 22).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 26, 2026.
Read through reviews of airlines operating flights from Des Moines to Knoxville, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,487 reviews

Comfort

7.8

Overall

7.8

Entertainment

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Delta
7.8
Good
8,487 reviews
Delta
7.8
Good
8,487 reviews

Comfort

7.8

Overall

7.8

Entertainment

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
United Airlines
7.4
Good
10,040 reviews
Delta
7.8
Good
8,487 reviews

Comfort

7.8

Overall

7.8

Entertainment

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
American Airlines
7.1
Good
11,844 reviews
Delta
7.8
Good
8,487 reviews

Comfort

7.8

Overall

7.8

Entertainment

7.8

Food

7.2

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Knoxville?

    A quick flight from Des Moines to Knoxville can take about 5h 43m. United Airlines provides one of the quickest options available for as low as $284. Des Moines and Knoxville are separated by a distance of 654 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Knoxville round-trip?

    According to our current data, American Airlines ($203), Delta ($203), and United Airlines ($299) offers the cheapest pricing from Des Moines to Knoxville. These flights start at 49% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to Knoxville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Knoxville.

  • Can I find deals for business class flights from Des Moines to Knoxville?

    Yes. Cheapflights offers flight deals from Des Moines to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

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Top 3 airlines flying from Des Moines to Knoxville

Discover the top 3 airlines that operate flights from Des Moines to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$349FlexibilityNo cancel feeOn-time71%
DeltaCheapest$203Average$386FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$299Average$387FlexibilityNo cancel feeOn-time69%

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