Cheap flights from Des Moines to Knoxville (DSM - TYS) from $148

This is the cheapest one-way flight price, found on 9/27. Prices may vary by date and flight preferences.
DSM — TYS
Oct 3 — Oct 101

The best prices from Des Moines to Knoxville McGhee Tyson are usually found in April or February, booked 41 days in advance, depart on a Tuesday or Friday and return on a Monday

How to find the cheapest flight from Des Moines (DSM) to Knoxville (TYS)

All the information you need to plan the best DSM to TYS flight in 2023: compare Des Moines to Knoxville flight prices with the expected peak season, weather and rainfall in Knoxville.

Popular in

June

Cheapest in

April

Round-trip from

$300

One-way from

$252
High demand for flights, 15% potential price rise
Best time to find cheap flights, 23% potential price drop
From Des Moines to Knoxville McGhee Tyson
One-way flight from Des Moines to Knoxville McGhee Tyson

DSM - TYS

Price

$300 - $514

TYS

Temperature

39.2 - 78.8 °F

TYS

Rainfall

2.7 - 4.8 inches

What is the cheapest day to fly round-trip from Des Moines to Knoxville?

Travelers have found that booking a Monday departure is the best way to save up to 123% on the cost of booking your flights compared to booking on days of the week where this route is of high demand.

How far in advance should I book a flight from Des Moines to Knoxville?

Find a great deal and save up to 42% by booking at least 42 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Des Moines to Knoxville within the next two weeks, with the cheapest ticket starting at $486.

What is the cheapest month to fly from Des Moines to Knoxville?

April can be a great time to fly to Knoxville from Des Moines with a flight ticket averaging about $470. Cheapflights users have found deals in the month of April for as cheap as $328. The most expensive prices can be found in the month of June.

When is the cheapest time to fly from Des Moines to Knoxville (DSM - TYS)?

When flying from Des Moines to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 35% versus a flight in the afternoon.

Cheap American Airlines flights from Des Moines to Knoxville

Check out some of the cheapest American Airlines flights we've come across from Des Moines to Knoxville. It's recommended that users confirm their flight details before booking.

Cheap Delta flights from Des Moines to Knoxville

Some of the lowest-priced Delta flights we've found at this time heading from Des Moines to Knoxville. If these deals don't fit your criteria, make sure to check back soon as new deals are always added.

Cheap Des Moines to Knoxville flights in September & October 2023

The best prices found for DSM to TYS flights for September, October
These are some of the best deals we've found on flights to Knoxville in 2023 at this time. Check back soon for alternative fares.

Des Moines to Knoxville 2023 flight deals

Cheap flights to Knoxville from Des Moines found for this year
These are some of the best deals we've found on flights to Knoxville in 2023 at this time. Check back soon for alternative fares.

One-way flights to Knoxville from Des Moines

The cheapest one-way flights from Des Moines to Knoxville
Take a look at some of the best available options we've come across on one-way flights from Des Moines to Knoxville. Users needing a return flight from Des Moines to Knoxville should utilize the search form above.

Find flights from Des Moines to Knoxville within your budget

Use the slider to find flights from Des Moines to Knoxville that fit your budget.

Fly from

Any airport

Fly to

Any airport

Budget

$238 - $806

Route

Depart

Return

Price

Des MoinesKnoxville McGhee Tyson

DSM - TYS

DSMTYS

Des Moines

Thu 11/2

1 stop21h 08m

Knoxville McGhee Tyson

Mon 11/6

1 stop18h 03m

Des MoinesKnoxville McGhee Tyson

DSM - TYS

DSMTYS

Des Moines

Wed 11/1

1 stop5h 10m

Knoxville McGhee Tyson

Wed 11/8

1 stop6h 18m

Des MoinesKnoxville McGhee Tyson

DSM - TYS

DSMTYS

Des Moines

Wed 11/1

1 stop5h 10m

Knoxville McGhee Tyson

Wed 11/8

2 stops7h 23m

Des MoinesKnoxville McGhee Tyson

DSM - TYS

DSMTYS

Des Moines

Sat 11/4

1 stop8h 04m

Knoxville McGhee Tyson

Tue 11/7

2 stops7h 23m

Des MoinesKnoxville McGhee Tyson

DSM - TYS

DSMTYS

Des Moines

Wed 11/1

2 stops7h 22m

Knoxville McGhee Tyson

Wed 11/8

2 stops7h 23m

Des MoinesKnoxville McGhee Tyson

DSM - TYS

DSMTYS

Des Moines

Fri 11/3

1 stop5h 24m

Knoxville McGhee Tyson

Tue 11/7

1 stop5h 10m

Des MoinesKnoxville McGhee Tyson

DSM - TYS

DSMTYS

Des Moines

Fri 11/10

1 stop4h 13m

Knoxville McGhee Tyson

Mon 11/13

1 stop7h 06m

Des MoinesKnoxville McGhee Tyson

DSM - TYS

DSMTYS

Des Moines

Fri 11/3

1 stop6h 31m

Knoxville McGhee Tyson

Mon 11/6

2 stops11h 46m

Des MoinesKnoxville McGhee Tyson

DSM - TYS

DSMTYS

Des Moines

Fri 10/13

3 stops24h 01m

Knoxville McGhee Tyson

Mon 10/16

1 stop9h 47m

Flights are sorted by cheapest first

Deals found on 9/26

Reviews of airlines servicing Knoxville

Read through reviews of airlines operating flights from Des Moines to Knoxville, such as American Airlines, Delta and Allegiant Air. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
3,023 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Boarding

8.0

Crew

8.5

Reviews

1 / 10

Best airline I’ve ever flown with. Take note American Airlines!

Delta
7.9
Good
3,023 reviews
Delta
7.9
Good
3,023 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Boarding

8.0

Crew

8.5

Reviews

1 / 10

Best airline I’ve ever flown with. Take note American Airlines!

Allegiant Air
7.5
Good
103 reviews
Delta
7.9
Good
3,023 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Boarding

8.0

Crew

8.5

Reviews

1 / 10

Best airline I’ve ever flown with. Take note American Airlines!

United Airlines
7.4
Good
1,890 reviews
Delta
7.9
Good
3,023 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Boarding

8.0

Crew

8.5

Reviews

1 / 10

Best airline I’ve ever flown with. Take note American Airlines!

American Airlines
7.2
Good
2,635 reviews
Delta
7.9
Good
3,023 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Boarding

8.0

Crew

8.5

Reviews

1 / 10

Best airline I’ve ever flown with. Take note American Airlines!

WestJet
7.2
Good
918 reviews
Delta
7.9
Good
3,023 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Boarding

8.0

Crew

8.5

Reviews

1 / 10

Best airline I’ve ever flown with. Take note American Airlines!

Related info for your journey

Useful info, stats and facts about Des Moines to Knoxville flights.

Can I find flights from Des Moines to Knoxville for under $300 on Cheapflights?

Yes, there are multiple flights from Des Moines to Knoxville for under $300. The cheapest flight booked recently is on Frontier for just $238, but on average you can expect to pay $358.

What are the cheapest airlines flying from Des Moines to Knoxville round-trip?

According to our current data, Frontier ($238), American Airlines ($263), and Delta ($325) offers the cheapest pricing from Des Moines to Knoxville. These flights start at 49% lower than the current average price 3 months from now.

What are the cheapest airlines to fly from Des Moines to Knoxville one-way?

The cheapest airlines for a one-way flight from Des Moines to Knoxville are Frontier ($165), Allegiant Air ($180), and American Airlines ($277).

What are the most popular airlines that fly from Des Moines to Knoxville?

What does DSM to TYS mean?

DSM and TYS are unique codes to identify airports used in the aviation industry. They are defined by IATA (International Air Transport Association) and are commonly called IATA codes. DSM to TYS refers to a flight route from Des Moines Airport to Knoxville McGhee Tyson Airport.

Alternative routes for Des Moines to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Des Moines to Knoxville

The chart below displays the airlines Cheapflights users traveling from Des Moines to Knoxville choose most often. Cheapest and average prices are based on aggregated data from the past 12 months.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$282Average$413FlexibilityNo cancel feeOn-time88%
Search Allegiant Air flights
American AirlinesCheapest$292Average$498FlexibilityNo cancel feeOn-time71%
Search American Airlines flights
United AirlinesCheapest$314Average$545FlexibilityNo cancel feeOn-time69%
Search United Airlines flights
DeltaCheapest$348Average$417FlexibilityNo cancel feeOn-timeN/A
Search Delta flights

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Why should you use Cheapflights to find cheap flight tickets from Des Moines to Knoxville?

Cheapflights taps into our reliable network of hundreds of airlines and travel agencies to find the best deals for flights from Des Moines to Knoxville for you. Better yet — we are completely free to use.

Can Cheapflights find flights from Des Moines to Knoxville with no change fees?

Yes, we can. To see specific flights from Des Moines to Knoxville with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Des Moines to Knoxville become cheaper?

Yes! Start tracking prices for Des Moines to Knoxville flights today and get alerted whenever prices for these flights change. To access this feature, navigate to the search form above to perform a search, which will then prompt you for a valid email address to use the tool.

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