Cheap flights from Des Moines to Knoxville (DSM - TYS)

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The best prices from Des Moines to Knoxville McGhee Tyson are usually found in February or October, booked 43 days in advance, depart on a Sunday or Tuesday and return on a Friday

How to find the cheapest flight from
Des Moines (DSM) to Knoxville (TYS)

All the information you need to plan the best DSM to TYS flight in 2022: compare Des Moines to Knoxville flight prices with the expected peak season, weather and rainfall in Knoxville.
DSM - TYS
Price
$308 - $493
TYS
Temperature
39.2 - 78.8 °F
TYS
Rainfall
2.7 - 4.8 inches

Popular in

November

High demand for flights, 19% potential price rise

Cheapest in

February

Best time to find cheap flights, 23% potential price drop

Round-trip from

$308

From Des Moines to Knoxville McGhee Tyson

One-way from

$295

One-way flight from Des Moines to Knoxville McGhee Tyson

Flight route prices based on searches on Cheapflights within the last 3 days, monthly prices based on aggregated historical data.
What is the cheapest day to fly round-trip from Des Moines to Knoxville?

Travelers have found that booking a Saturday departure is the best way to save up to 32% on the cost of booking your flights compared to booking on days of the week where this route is of high demand.

When is the cheapest time to fly from Des Moines to Knoxville (DSM - TYS)?

When flying from Des Moines to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 94% versus a flight in the morning.

How far in advance should I book a flight from Des Moines to Knoxville?

Find a great deal and save up to 36% by booking at least 35 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Des Moines to Knoxville within the next two weeks, with the cheapest ticket starting at $428.

What is the cheapest month to fly from Des Moines to Knoxville?

February can be a great time to fly to Knoxville from Des Moines with a flight ticket averaging about $401. Cheapflights users have found deals in the month of February for as cheap as $285. The most expensive prices can be found in the month of November.

Cheap flights from Des Moines to Knoxville in June, July 2022

The best prices found for DSM to TYS flights for June, July
25 Jul - 29 Jul
$362pp
DSM
Des Moines
Allegiant Air
 
1 STOP
TYS
Knoxville McGhee Tyson
TYS
Knoxville McGhee Tyson
Allegiant Air
 
1 STOP
DSM
Des Moines
26 Jul - 30 Jul
$373pp
DSM
Des Moines
Allegiant Air
   
2 STOPS
TYS
Knoxville McGhee Tyson
TYS
Knoxville McGhee Tyson
Allegiant Air
 
1 STOP
DSM
Des Moines
26 Jul - 30 Jul
$441pp
DSM
Des Moines
Allegiant Air
   
2 STOPS
TYS
Knoxville McGhee Tyson
TYS
Knoxville McGhee Tyson
Allegiant Air
   
2 STOPS
DSM
Des Moines

Des Moines to Knoxville 2022 flight deals

Cheap flights to Knoxville from Des Moines found for this year
12 Aug - 15 Aug
$312pp
DSM
Des Moines
Allegiant Air
 
1 STOP
TYS
Knoxville McGhee Tyson
TYS
Knoxville McGhee Tyson
Allegiant Air
 
1 STOP
DSM
Des Moines
26 Sep - 29 Sep
$341pp
DSM
Des Moines
Multiple Airlines
 
1 STOP
TYS
Knoxville McGhee Tyson
TYS
Knoxville McGhee Tyson
Multiple Airlines
 
1 STOP
DSM
Des Moines
6 Aug - 11 Aug
$355pp
DSM
Des Moines
Multiple Airlines
 
1 STOP
TYS
Knoxville McGhee Tyson
TYS
Knoxville McGhee Tyson
Multiple Airlines
 
1 STOP
DSM
Des Moines

One-way flights to McGhee Tyson from Des Moines

The cheapest one-way flights from Des Moines to Knoxville
1:55 pm - 7:52 pm
Delta
1 Stop
4h 57m
DSM - TYS
Delta
$295
Delta
2:02 am - 3:49 pm
United Airlines
2 Stops
12h 47m
DSM - TYS
United Airlines
$296
United
8:57 am - 7:45 am
Multiple Airlines
3 Stops
21h 48m
DSM - TYS
Multiple Airlines
$379
Gotogate

Related info for your journey

Useful info, stats and facts about <span class="emphasized">Des Moines</span> to <span class="emphasized">Knoxville</span> flights.

Flight FAQs

From Des Moines to Knoxville

Which airlines flying from Des Moines to Knoxville McGhee Tyson have flexible cancellations due to COVID-19?

Due to the rapidly changing circumstances due to COVID-19, airlines like American Airlines, Delta, and United Airlines flying from Des Moines to Knoxville McGhee Tyson have implemented new flexible cancellation policies.

Can I find flights from Des Moines to Knoxville for under $400 on Cheapflights?

Yes, there are multiple flights from Des Moines to Knoxville for under $400. The cheapest flight booked recently is on Allegiant Air for just $312, but on average you can expect to pay $408.

What are the cheapest airlines flying from Des Moines to Knoxville round-trip?

According to our current data, Allegiant Air ($312), American Airlines ($395), and Delta ($398) offers the cheapest pricing from Des Moines to Knoxville. These flights start at 22% lower than the current average price 3 months from now.

What are the cheapest airlines to fly from Des Moines to Knoxville one-way?

The cheapest airlines for a one-way flight from Des Moines to Knoxville are Allegiant Air ($113), Delta ($239), and United Airlines ($296).

What are the most popular airlines that fly from Des Moines to Knoxville?

Consider American Airlines, Delta or Allegiant Air when booking your flight. These represent the most popular airlines when flying from Des Moines to Knoxville.

What are the cheapest flights from Des Moines to Knoxville?

The cheapest flight price from Des Moines to Knoxville is $290. On average you can expect to pay $573. The most popular route, (Des Moines - Knoxville McGhee Tyson), can usually be booked for $312.

COVID Restrictions

View COVID Travel Restrictions for Knoxville, TN

Do I need a COVID test to fly to Knoxville from Des Moines?

Information is based on travel restrictions for travel to Knoxville McGhee Tyson within the United States

Most visitors from Des Moines need to provide a negative COVID-19 test result and/or quarantine to enter Knoxville McGhee Tyson.

COVID-19 testing requirements
Visitors from Des Moines are not required to present a negative COVID-19 PCR test or antigen result upon entering Knoxville McGhee Tyson.

Quarantine requirements
Visitors from Des Moines are not required to quarantine after entering Knoxville McGhee Tyson.

Do I need a test to fly back to Des Moines from Knoxville?

Returning to Des Moines from Knoxville McGhee Tyson

COVID-19 testing requirements
Visitors from Knoxville McGhee Tyson are not required to present a negative COVID-19 PCR test or antigen result upon entering Des Moines.

Quarantine requirements
Visitors from Knoxville McGhee Tyson are not required to quarantine after entering Des Moines.

Hide COVID Travel Restrictions for Knoxville, TN

Alternative routes for Des Moines to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Destination information for Knoxville

Things to know before you go - useful duration and weather info for your trip from Des Moines to Knoxville.
Average temperature for June in Knoxville
86.0 °F
Avg rainfall for June in Knoxville
4.0 ″

Airports servicing Des Moines

Airports servicing Knoxville

Top 5 airlines flying from Des Moines to Knoxville McGhee Tyson

The chart below displays the airlines Cheapflights users traveling from Des Moines to Knoxville choose most often. Cheapest and average prices are based on aggregated data from the past 12 months.
Airline Cheapest Average Flexibility On-time COVID-19 safety
Juneyao Airlines
$14 $22 No cancel fee 66%

We couldn't confirm the COVID-19 safety measures taken by Juneyao Airlines. Please check directly on their website for additional information.

Allegiant Air
$247 $353 No cancel fee 88%
Delta
$275 $410 No cancel fee N/A
United Airlines
$307 $389 No cancel fee 69%
American Airlines
$326 $411 No cancel fee 71%
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