HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$129+ Cheap flights from Des Moines to Knoxville (DSM - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
May 27 — Jun 31
Wed 5/27
Wed 6/3
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Knoxville

Cheapest flights from Des Moines to Knoxville
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 27, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:00 am
DSM
-
TYS
1 stop6h 03m
Allegiant Air
Thu 5/211:03 pm
TYS
-
DSM
1 stop10h 28m
Allegiant Air
Deal found 4/23$216
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:45 am
DSM
-
TYS
1 stop12h 05m
Allegiant Air
Thu 5/211:03 pm
TYS
-
DSM
1 stop10h 28m
Allegiant Air
Deal found 4/23$225
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:41 pm
DSM
-
TYS
1 stop4h 20m
Delta
Thu 6/45:40 am
TYS
-
DSM
1 stop6h 28m
Delta
Deal found 4/23$226
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:08 pm
DSM
-
TYS
1 stop27h 52m
Allegiant Air
Mon 7/137:20 pm
TYS
-
DSM
1 stop21h 04m
Allegiant Air
Deal found 4/23$240
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/182:03 pm
DSM
-
TYS
1 stop23h 55m
Allegiant Air
Thu 5/211:03 pm
TYS
-
DSM
1 stop10h 28m
Allegiant Air
Deal found 4/23$242
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:41 pm
DSM
-
TYS
1 stop4h 15m
Delta
Wed 5/205:40 am
TYS
-
DSM
1 stop6h 28m
Delta
Deal found 4/23$253
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:33 pm
DSM
-
TYS
1 stop17h 36m
Allegiant Air
Thu 5/211:03 pm
TYS
-
DSM
1 stop10h 28m
Allegiant Air
Deal found 4/23$254
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:00 am
DSM
-
TYS
1 stop6h 03m
Allegiant Air
Sat 5/231:45 pm
TYS
-
DSM
1 stop10h 48m
Allegiant Air
Deal found 4/23$257
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/273:01 pm
DSM
-
TYS
1 stop7h 11m
United Airlines
Thu 6/46:30 am
TYS
-
DSM
1 stop4h 57m
United Airlines
Deal found 4/22$259
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:45 am
DSM
-
TYS
1 stop12h 05m
Allegiant Air
Sat 5/231:45 pm
TYS
-
DSM
1 stop10h 48m
Allegiant Air
Deal found 4/23$267
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:12 pm
DSM
-
TYS
1 stop28h 12m
Allegiant Air
Mon 8/109:26 am
TYS
-
DSM
1 stop8h 51m
Allegiant Air
Deal found 4/22$280

Find flight deals from Des Moines to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$216
(Kiwi.com)

One-way from

$129
(Kiwi.com)

Popular in

October

Cheapest in

November

Average price

$415
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
Search Deals
From Des Moines to Knoxville McGhee Tyson
Search Deals
One-way flight from Des Moines to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 5/28

6:41 pm-11:56 pm

1 stop4h 15m

Knoxville McGhee Tyson

Wed 6/3

5:20 pm-8:36 pm

1 stop4h 16m

$226

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 5/19

6:41 pm-11:56 pm

1 stop4h 15m

Knoxville McGhee Tyson

Wed 5/20

5:40 am-11:08 am

1 stop6h 28m

$253

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 5/28

10:26 am-5:27 pm

1 stop6h 01m

Knoxville McGhee Tyson

Sun 5/31

6:36 am-12:24 pm

1 stop6h 48m

$351

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 5/15

6:41 pm-11:56 pm

1 stop4h 15m

Knoxville McGhee Tyson

Wed 5/20

5:40 am-11:08 am

1 stop6h 28m

$355

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/16

4:00 pm-11:56 pm

1 stop6h 56m

Knoxville McGhee Tyson

Tue 5/19

5:40 am-11:08 am

1 stop6h 28m

$355

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 5/19

6:41 pm-11:56 pm

1 stop4h 15m

Knoxville McGhee Tyson

Fri 5/22

1:59 pm-5:53 pm

1 stop4h 54m

$355

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 7/2

5:10 am-9:10 pm

2 stops15h 00m

Knoxville McGhee Tyson

Mon 7/6

6:40 am-10:20 pm

2 stops16h 40m

$410

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 5/28

5:25 am-6:10 pm

2 stops11h 45m

Knoxville McGhee Tyson

Wed 6/3

7:05 am-2:05 pm

2 stops8h 00m

$441

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/9

6:40 am-3:20 pm

2 stops7h 40m

Knoxville McGhee Tyson

Wed 5/13

12:50 pm-10:10 pm

2 stops10h 20m

$447

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 5/28

6:00 am-2:27 pm

2 stops7h 27m

Knoxville McGhee Tyson

Sun 5/31

6:30 am-10:22 am

1 stop4h 52m

$471

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/26

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Knoxville

How much does it cost to fly round-trip from Des Moines to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 27, 2026.
Read through reviews of airlines operating flights from Des Moines to Knoxville, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,463 reviews

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,463 reviews
Delta
7.9
Good
8,463 reviews

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,665 reviews
Delta
7.9
Good
8,463 reviews

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,668 reviews
Delta
7.9
Good
8,463 reviews

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Knoxville?

    A quick flight from Des Moines to Knoxville can take about 4h 15m. Delta provides one of the quickest options available for as low as $226. Des Moines and Knoxville are separated by a distance of 654 mi.

  • What are the cheapest airlines flying from Des Moines to Knoxville round-trip?

    According to our current data, American Airlines ($203), Delta ($203), and United Airlines ($299) offers the cheapest pricing from Des Moines to Knoxville. These flights start at 45% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to Knoxville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Knoxville.

  • Can I find deals for business class flights from Des Moines to Knoxville?

    Yes. Cheapflights offers flight deals from Des Moines to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Des Moines to Knoxville

Discover the top 3 airlines that operate flights from Des Moines to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$358FlexibilityNo cancel feeOn-time71%
DeltaCheapest$203Average$308FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$299Average$387FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.