$144+ Cheap flights from Des Moines to Knoxville (DSM - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Oct 7 — Oct 141
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to KnoxvilleExplore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:41 am -
1 stop6h 12m
Sat 10/38:14 pm -
1 stop4h 50m
Deal found 9/3![American Airlines logo]()
$317
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:24 am -
1 stop5h 54m
Sat 10/39:45 am -
2 stops9h 03m
Deal found 9/3![United Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:27 pm -
1 stop7h 47m
Sat 10/1010:42 am -
1 stop4h 33m
Deal found 9/5![United Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:41 am -
1 stop6h 12m
Tue 9/296:16 pm -
1 stop6h 25m
Deal found 9/5![American Airlines logo]()
$345
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:24 am -
2 stops7h 13m
Mon 10/56:00 am -
1 stop5h 31m
Deal found 9/3![United Airlines logo]()
$346
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/198:03 am -
1 stop6h 19m
Wed 9/237:15 am -
1 stop7h 28m
Deal found 9/4![American Airlines logo]()
$347
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:32 am -
1 stop4h 26m
Tue 9/295:45 am -
2 stops7h 49m
Deal found 9/5![United Airlines logo]()
$360
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/103:11 pm -
1 stop4h 38m
Wed 10/1410:42 am -
1 stop4h 33m
Deal found 9/6![United Airlines logo]()
$371
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:23 pm -
2 stops9h 36m
Wed 9/236:00 pm -
1 stop4h 27m
Deal found 9/5![United Airlines logo]()
$372
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:50 am -
2 stops12h 50m
Sat 10/246:40 am -
2 stops8h 00m
Deal found 9/5![Southwest logo]()
$381
Best flights from Des Moines to KnoxvilleDiscover carefully curated flight deals from Des Moines to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
Discover carefully curated flight deals from Des Moines to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:27 pm -
1 stop7h 47m
Sat 10/1010:42 am -
1 stop4h 33m
Deal found 9/5![United Airlines logo]()
$343
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/86:55 am -
1 stop7h 50m
Sun 1/108:00 am -
2 stops14h 35m
Deal found 9/6![Southwest logo]()
$366
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:30 am -
1 stop14h 06m
Mon 9/216:30 am -
1 stop15h 11m
Deal found 9/2![Allegiant Air logo]()
$492
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:32 am -
1 stop4h 26m
Tue 9/295:45 am -
2 stops7h 49m
Deal found 9/5![United Airlines logo]()
$360
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:30 am -
2 stops11h 15m
Wed 9/231:55 pm -
2 stops9h 05m
Deal found 9/4![Southwest logo]()
$409
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/11:27 pm -
1 stop8h 05m
Thu 11/59:45 am -
2 stops8h 43m
Deal found 9/6![United Airlines logo]()
$470
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:40 am -
2 stops10h 30m
Tue 9/2212:45 pm -
2 stops10h 15m
Deal found 9/3![Southwest logo]()
$513
Last-minute flights from Des Moines to KnoxvilleDiscover last-minute flight deals from Des Moines to Knoxville. Data last updated September 7, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Knoxville. Data last updated September 7, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/198:03 am -
1 stop6h 19m
Wed 9/237:15 am -
1 stop7h 28m
Deal found 9/4![American Airlines logo]()
$347
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:23 pm -
2 stops9h 36m
Wed 9/236:00 pm -
1 stop4h 27m
Deal found 9/5![United Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:41 am -
1 stop6h 12m
Sat 10/38:14 pm -
1 stop4h 50m
Deal found 9/3![American Airlines logo]()
$317
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:24 am -
1 stop5h 54m
Sat 10/39:45 am -
2 stops9h 03m
Deal found 9/3![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:41 am -
1 stop6h 12m
Tue 9/296:16 pm -
1 stop6h 25m
Deal found 9/5![American Airlines logo]()
$345
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:32 am -
1 stop4h 26m
Tue 9/295:45 am -
2 stops7h 49m
Deal found 9/5![United Airlines logo]()
$360
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:24 am -
2 stops7h 13m
Mon 10/56:00 am -
1 stop5h 31m
Deal found 9/3![United Airlines logo]()
$346
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:27 pm -
1 stop7h 47m
Sat 10/1010:42 am -
1 stop4h 33m
Deal found 9/5![United Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/103:11 pm -
1 stop4h 38m
Wed 10/1410:42 am -
1 stop4h 33m
Deal found 9/6![United Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:50 am -
2 stops12h 50m
Sat 10/246:40 am -
2 stops8h 00m
Deal found 9/5![Southwest logo]()
$381
One-way flights from Des Moines to KnoxvilleSearch for one-way flight options from Des Moines to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
Search for one-way flight options from Des Moines to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:10 pm -
1 stop5h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Delta logo]()
$144
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2611:27 am -
2 stops8h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![United Airlines logo]()
$149
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/261:30 pm -
1 stop6h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![American Airlines logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:30 pm -
3 stops43h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/259:59 am -
1 stop12h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Allegiant Air logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:42 pm -
3 stops31h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:00 am -
3 stops36h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Allegiant Air logo]()
$361
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:55 pm -
2 stops22h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![United Airlines logo]()
$385
Find flight deals from Des Moines to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $317 (American Airlines) |
One-way from | $144 (Delta) |
Popular in | September |
Cheapest in | November |
Average price | $488 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Wed 10/14
1:24 pm-8:49 pm
1 stop6h 25m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$144
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Sat 9/26
11:27 am-8:45 pm
2 stops8h 18m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$149
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Fri 9/25
9:59 am-11:21 pm
1 stop12h 22m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$265
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Wed 10/14
2:42 pm-11:21 pm
3 stops31h 39m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$316
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Sat 10/3
1:27 pm-10:14 pm
1 stop7h 47m
Knoxville McGhee Tyson
Sat 10/10
10:42 am-2:15 pm
1 stop4h 33m
$343
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Tue 9/22
11:32 am-4:58 pm
1 stop4h 26m
Knoxville McGhee Tyson
Tue 9/29
5:45 am-12:34 pm
2 stops7h 49m
$360
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Sat 9/26
8:00 am-9:55 pm
3 stops36h 55m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$361
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Fri 1/8
6:55 am-3:45 pm
1 stop7h 50m
Knoxville McGhee Tyson
Sun 1/10
8:00 am-9:35 pm
2 stops14h 35m
$366
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Fri 9/25
6:55 pm-6:05 pm
2 stops22h 10m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$385
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Sat 9/19
5:30 am-5:45 pm
2 stops11h 15m
Knoxville McGhee Tyson
Wed 9/23
1:55 pm-10:00 pm
2 stops9h 05m
$409
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.
DSM-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 7, 2026.
Read through reviews of airlines operating flights from Des Moines to Knoxville, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Overall
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Overall
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Overall
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Overall
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Other flights from Des Moines
Popular flights
Alternative routes for Des Moines to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Knoxville by cabin class
Find flights from Des Moines to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 7, 2026.
Des Moines and Knoxville flights
Browse other Des Moines and Knoxville flight options. Last updated on September 7, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Knoxville
Discover the top 3 airlines that operate flights from Des Moines to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$203 | Average$326 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$203 | Average$386 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$299 | Average$387 | FlexibilityNo cancel fee | On-time69% |