$115+ Cheap flights from Des Moines to Knoxville (DSM - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Jul 7 — Jul 141
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to KnoxvilleExplore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 7, 2026.
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:12 pm
DSM
- TYS
1 stop28h 12m
Allegiant Air
Sun 8/92:56 pm
TYS
- DSM
1 stop7h 35m
Allegiant Air
Deal found 6/4![Allegiant Air logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Thu 6/254:05 pm
TYS
- DSM
1 stop6h 42m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:08 pm
DSM
- TYS
1 stop27h 52m
Allegiant Air
Wed 7/152:23 pm
TYS
- DSM
1 stop19h 10m
Allegiant Air
Deal found 6/3![Allegiant Air logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/210:57 am
DSM
- TYS
1 stop24h 06m
Allegiant Air
Sun 8/92:56 pm
TYS
- DSM
1 stop7h 35m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- TYS
1 stop6h 37m
Allegiant Air
Fri 7/108:30 am
TYS
- DSM
1 stop14h 45m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:02 pm
DSM
- TYS
1 stop27h 44m
Allegiant Air
Sat 7/41:00 pm
TYS
- DSM
1 stop11h 31m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/104:40 pm
DSM
- TYS
1 stop14h 52m
Allegiant Air
Mon 7/138:30 am
TYS
- DSM
1 stop14h 45m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:12 pm
DSM
- TYS
2 stops14h 24m
Multiple Airlines
Sun 8/92:56 pm
TYS
- DSM
1 stop7h 35m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Sat 6/271:00 pm
TYS
- DSM
1 stop11h 28m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$312
Best flights from Des Moines to KnoxvilleDiscover carefully curated flight deals from Des Moines to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 7, 2026.
Discover carefully curated flight deals from Des Moines to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:08 pm
DSM
- TYS
1 stop27h 52m
Allegiant Air
Wed 7/152:23 pm
TYS
- DSM
1 stop19h 10m
Allegiant Air
Deal found 6/3![Allegiant Air logo]()
$259
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:15 am
DSM
- TYS
1 stop8h 15m
Southwest
Sat 9/126:50 am
TYS
- DSM
2 stops8h 20m
Southwest
Deal found 6/3![Southwest logo]()
$331
This United Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:29 am
DSM
- TYS
2 stops7h 08m
United Airlines
Sat 9/125:45 am
TYS
- DSM
2 stops7h 31m
United Airlines
Deal found 6/3![United Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/274:22 pm
DSM
- TYS
1 stop5h 33m
Multiple Airlines
Mon 6/297:22 pm
TYS
- DSM
2 stops42h 37m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$395
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/192:25 pm
DSM
- TYS
1 stop6h 10m
Delta
Wed 7/225:23 pm
TYS
- DSM
1 stop4h 26m
Delta
Deal found 6/3![Delta logo]()
$402
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:20 am
DSM
- TYS
2 stops10h 40m
Southwest
Sun 8/27:00 pm
TYS
- DSM
2 stops5h 50m
Southwest
Deal found 6/5![Southwest logo]()
$352
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:50 am
DSM
- TYS
1 stop9h 03m
United Airlines
Fri 7/1010:00 am
TYS
- DSM
2 stops12h 22m
United Airlines
Deal found 6/7![United Airlines logo]()
$353
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/163:22 pm
DSM
- TYS
1 stop6h 27m
United Airlines
Sat 9/196:00 am
TYS
- DSM
1 stop7h 16m
United Airlines
Deal found 6/6![United Airlines logo]()
$357
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:10 am
DSM
- TYS
2 stops7h 10m
Southwest
Sat 9/196:50 am
TYS
- DSM
2 stops8h 20m
Southwest
Deal found 6/6![Southwest logo]()
$367
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:10 am
DSM
- TYS
2 stops5h 40m
Southwest
Fri 7/106:40 am
TYS
- DSM
2 stops16h 45m
Southwest
Deal found 6/5![Southwest logo]()
$374
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:10 am
DSM
- TYS
2 stops9h 35m
Southwest
Sun 8/98:30 am
TYS
- DSM
2 stops15h 20m
Southwest
Deal found 6/7![Southwest logo]()
$473
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:10 am
DSM
- TYS
2 stops7h 55m
Southwest
Mon 6/296:40 am
TYS
- DSM
2 stops16h 40m
Southwest
Deal found 6/3![Southwest logo]()
$519
Last-minute flights from Des Moines to KnoxvilleDiscover last-minute flight deals from Des Moines to Knoxville. Data last updated June 7, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Knoxville. Data last updated June 7, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:00 am
DSM
- TYS
1 stop15h 40m
Allegiant Air
Fri 6/269:17 pm
TYS
- DSM
1 stop19h 15m
Allegiant Air
Deal found 6/3![Allegiant Air logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:02 pm
DSM
- TYS
1 stop27h 48m
Allegiant Air
Thu 6/254:05 pm
TYS
- DSM
1 stop6h 42m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Thu 6/254:05 pm
TYS
- DSM
1 stop6h 42m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Sat 6/271:00 pm
TYS
- DSM
1 stop11h 28m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Fri 6/269:17 pm
TYS
- DSM
1 stop19h 15m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:02 pm
DSM
- TYS
1 stop27h 44m
Allegiant Air
Sat 7/41:00 pm
TYS
- DSM
1 stop11h 31m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- TYS
1 stop6h 37m
Allegiant Air
Fri 7/108:30 am
TYS
- DSM
1 stop14h 45m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:08 pm
DSM
- TYS
1 stop27h 52m
Allegiant Air
Wed 7/152:23 pm
TYS
- DSM
1 stop19h 10m
Allegiant Air
Deal found 6/3![Allegiant Air logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/104:40 pm
DSM
- TYS
1 stop14h 52m
Allegiant Air
Mon 7/138:30 am
TYS
- DSM
1 stop14h 45m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$286
One-way flights from Des Moines to KnoxvilleSearch for one-way flight options from Des Moines to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 7, 2026.
Search for one-way flight options from Des Moines to Knoxville. Find affordable one-way fares based on user searches. Data last updated June 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/144:01 pm
DSM
- TYS
1 stop28h 49m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:00 am
DSM
- TYS
1 stop15h 53m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$152
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/234:48 pm
DSM
- TYS
1 stop6h 03m
American Airlines
Deal found 6/7![American Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:02 pm
DSM
- TYS
1 stop27h 48m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:00 am
DSM
- TYS
1 stop15h 53m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$214
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/215:35 am
DSM
- TYS
1 stop4h 34m
Delta
Deal found 6/7![Delta logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1711:00 am
DSM
- TYS
2 stops29h 14m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:54 pm
DSM
- TYS
1 stop21h 35m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/215:02 pm
DSM
- TYS
3 stops27h 11m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/144:01 pm
DSM
- TYS
3 stops41h 41m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$292
Find flight deals from Des Moines to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $212 (Kiwi.com) |
One-way from | $142 (Kiwi.com) |
Popular in | October |
Cheapest in | November |
Average price | $370 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 7, 2026.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Thu 7/9
5:08 pm-10:00 pm
1 stop27h 52m
Knoxville McGhee Tyson
Wed 7/15
2:23 pm-8:33 am
1 stop19h 10m
$259
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Wed 9/9
7:15 am-4:30 pm
1 stop8h 15m
Knoxville McGhee Tyson
Sat 9/12
6:50 am-2:10 pm
2 stops8h 20m
$331
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Wed 9/9
6:29 am-2:37 pm
2 stops7h 08m
Knoxville McGhee Tyson
Sat 9/12
5:45 am-12:16 pm
2 stops7h 31m
$336
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Wed 7/29
5:20 am-5:00 pm
2 stops10h 40m
Knoxville McGhee Tyson
Sun 8/2
7:00 pm-11:50 pm
2 stops5h 50m
$352
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Sat 7/4
5:50 am-3:53 pm
1 stop9h 03m
Knoxville McGhee Tyson
Fri 7/10
10:00 am-9:22 pm
2 stops12h 22m
$353
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Wed 9/16
3:22 pm-10:49 pm
1 stop6h 27m
Knoxville McGhee Tyson
Sat 9/19
6:00 am-12:16 pm
1 stop7h 16m
$357
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Wed 9/16
6:10 am-2:20 pm
2 stops7h 10m
Knoxville McGhee Tyson
Sat 9/19
6:50 am-2:10 pm
2 stops8h 20m
$367
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Sat 7/4
5:10 am-11:50 am
2 stops5h 40m
Knoxville McGhee Tyson
Fri 7/10
6:40 am-10:25 pm
2 stops16h 45m
$374
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Sat 6/27
4:22 pm-10:55 pm
1 stop5h 33m
Knoxville McGhee Tyson
Mon 6/29
7:22 pm-12:59 pm
2 stops42h 37m
$395
Quickest round-trip
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Sun 7/19
2:25 pm-9:35 pm
1 stop6h 10m
Knoxville McGhee Tyson
Wed 7/22
5:23 pm-8:49 pm
1 stop4h 26m
$402
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Knoxville in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.
DSM-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 7, 2026.
Read through reviews of airlines operating flights from Des Moines to Knoxville, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Overall
7.9
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Overall
7.9
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Overall
7.9
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Overall
7.9
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge
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Top 3 airlines flying from Des Moines to Knoxville
Discover the top 3 airlines that operate flights from Des Moines to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$203 | Average$365 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$203 | Average$353 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$299 | Average$387 | FlexibilityNo cancel fee | On-time69% |