Knoxville

$131+ Cheap flights from Des Moines to Knoxville (DSM - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Feb 11 — Feb 181
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The best prices from Des Moines to Knoxville McGhee Tyson are usually found in January or July, booked 21 days in advance, depart on a Saturday or Tuesday and return on a Thursday

Cheap flight deals from Des Moines to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 6, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$224
(American Airlines)

One-way from

$131
(Mytrip)

Popular in

June

Cheapest in

January

Average price

$391
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
From Des Moines to Knoxville McGhee Tyson
One-way flight from Des Moines to Knoxville McGhee Tyson
Highest demand for flights based on searches. 7% potential increase in price ($27 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Average for round-trip flights in February 2025

Find flight deals from Des Moines to Knoxville

Cheapest flights from Des Moines to Knoxville
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 6, 2025.

This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/185:50 amDSM - TYS
1 stop4h 24mAmerican Airlines
Wed 2/266:55 pmTYS - DSM
1 stop4h 33mAmerican Airlines
Deal found 2/5$224
This Delta deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/76:26 pmDSM - TYS
1 stop4h 21mDelta
Sun 3/96:45 amTYS - DSM
1 stop9h 03mDelta
Deal found 2/5$249
This Mytrip deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/197:00 amDSM - TYS
1 stop10h 11mAllegiant Air
Fri 2/215:04 pmTYS - DSM
1 stop6h 07mAllegiant Air
Deal found 2/6$297
This Mytrip deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/31:32 pmDSM - TYS
3 stops28h 07mMultiple Airlines
Mon 3/1011:15 amTYS - DSM
1 stop12h 17mMultiple Airlines
Deal found 2/5$327
This United Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/263:28 pmDSM - TYS
2 stops7h 26mUnited Airlines
Wed 4/25:45 amTYS - DSM
2 stops9h 53mUnited Airlines
Deal found 2/5$329

Find flights from Des Moines to Knoxville within your budget

Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 6, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 2/18

5:50 am-11:14 am

1 stop4h 24m

Knoxville McGhee Tyson

Wed 2/26

6:55 pm-10:28 pm

1 stop4h 33m

$224

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 3/6

6:30 am-12:14 pm

1 stop4h 44m

Knoxville McGhee Tyson

Tue 3/11

11:31 am-7:09 pm

1 stop8h 38m

$249

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 3/3

1:32 pm-6:39 pm

3 stops28h 07m

Knoxville McGhee Tyson

Mon 3/10

11:15 am-10:32 pm

1 stop12h 17m

$327

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 3/26

3:28 pm-11:54 pm

2 stops7h 26m

Knoxville McGhee Tyson

Wed 4/2

5:45 am-2:38 pm

2 stops9h 53m

$329

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 6/10

7:00 am-5:55 pm

1 stop9h 55m

Knoxville McGhee Tyson

Fri 6/13

7:15 am-2:45 pm

1 stop8h 30m

$417

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 4/12

7:30 am-8:31 pm

1 stop12h 01m

$131

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 4/12

12:49 pm-9:23 pm

2 stops7h 34m

$225

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sun 2/23

7:00 am-6:20 pm

3 stops34h 20m

$306

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 5/15

11:26 am-10:05 am

3 stops21h 39m

$546

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/5

Compare providers for flights from Des Moines to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Knoxville in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines to Knoxville

Get recent, data-driven insights about flights from Des Moines to Knoxville including ideal travel times, pricing trends, and more.

How far ahead should I book a flight from Des Moines to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Knoxville. Price data was last updated on January 31, 2025.

Booking 21 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Des Moines to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Knoxville (average of $295). Flying from Des Moines to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated February 6, 2025.
8.0
Very good

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Crew

8.5

Overall

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

8.0
Very good
8.0
Very good

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Crew

8.5

Overall

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

8.0
Very good

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Crew

8.5

Overall

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

8.0
Very good

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Crew

8.5

Overall

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

8.0
Very good

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Crew

8.5

Overall

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What are the cheapest airlines flying from Des Moines to Knoxville round-trip?

    According to our current data, American Airlines ($224), Delta ($249), and United Airlines ($329) offers the cheapest pricing from Des Moines to Knoxville. These flights start at 38% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Knoxville one-way?

    The cheapest airlines for a one-way flight from Des Moines to Knoxville are Allegiant Air ($131), American Airlines ($225), and United Airlines ($379).

  • Can I find deals for flights from Des Moines to Knoxville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Knoxville.

  • Can I find deals for business class flights from Des Moines to Knoxville?

    Yes. Cheapflights offers flight deals from Des Moines to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Knoxville (average of $295). Flying from Des Moines to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Morristown
Corbin
Cherokee
Maryville
Oak Ridge
Alcoa
Murphy

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Top 3 airlines flying from Des Moines to Knoxville

Discover the top 3 airlines that operate flights from Des Moines to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$232Average$329FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$233Average$345FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$502FlexibilityNo cancel feeOn-time69%
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