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$135+ Cheap flights from Des Moines to Memphis (DSM - MEM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEM
May 24 — May 311
Sun 5/24
Sun 5/31
1 adult, Economy
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Cheap flight deals from Des Moines to Memphis

Cheapest flights from Des Moines to Memphis
Explore the most affordable flight options available from Des Moines to Memphis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.

This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:01 pm
DSM
-
MEM
1 stop5h 03m
American Airlines
Sat 5/235:00 am
MEM
-
DSM
1 stop7h 52m
American Airlines
Deal found 4/24$279
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:30 am
DSM
-
MEM
1 stop6h 15m
Southwest
Sun 6/75:10 am
MEM
-
DSM
1 stop6h 15m
Southwest
Deal found 4/23$288
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:15 pm
DSM
-
MEM
1 stop7h 35m
Southwest
Sat 5/235:25 am
MEM
-
DSM
2 stops7h 55m
Southwest
Deal found 4/19$299
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:20 pm
DSM
-
MEM
1 stop7h 05m
Southwest
Wed 5/205:15 am
MEM
-
DSM
1 stop6h 10m
Southwest
Deal found 4/20$300
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/153:20 pm
DSM
-
MEM
1 stop7h 38m
American Airlines
Sat 5/235:00 am
MEM
-
DSM
1 stop7h 52m
American Airlines
Deal found 4/23$313
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:28 pm
DSM
-
MEM
1 stop4h 52m
Delta
Fri 5/296:00 am
MEM
-
DSM
1 stop6h 24m
Delta
Deal found 4/21$332
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:20 pm
DSM
-
MEM
1 stop7h 05m
Southwest
Sun 5/315:10 am
MEM
-
DSM
1 stop6h 15m
Southwest
Deal found 4/19$341

Find flight deals from Des Moines to Memphis

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Memphis (MEM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$288
(Southwest)

One-way from

$135
(Kiwi.com)

Popular in

November

Cheapest in

June

Average price

$351
Provider with most accurate pricing for Des Moines-Memphis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Memphis flights.
Search Deals
From Des Moines to Memphis
Search Deals
One-way flight from Des Moines to Memphis
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($27 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Memphis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from Des Moines to Memphis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 5/21

7:01 pm-12:04 am

1 stop5h 03m

Memphis

Thu 5/28

6:34 pm-11:57 pm

1 stop5h 23m

$279

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 6/3

5:30 am-5:30 pm

2 stops12h 00m

Memphis

Sun 6/7

5:10 am-11:25 am

1 stop6h 15m

$293

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 5/20

3:15 pm-10:50 pm

1 stop7h 35m

Memphis

Sat 5/23

5:25 am-1:20 pm

2 stops7h 55m

$299

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 5/15

4:20 pm-11:25 pm

1 stop7h 05m

Memphis

Wed 5/20

5:15 am-11:25 am

1 stop6h 10m

$300

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 5/22

5:28 pm-10:20 pm

1 stop4h 52m

Memphis

Fri 5/29

6:00 am-12:24 pm

1 stop6h 24m

$332

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 5/29

4:20 pm-11:25 pm

1 stop7h 05m

Memphis

Sun 5/31

12:20 pm-10:20 pm

2 stops10h 00m

$346

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 5/21

6:50 am-4:40 pm

2 stops9h 50m

Memphis

Thu 5/28

4:25 pm-11:05 pm

2 stops6h 40m

$350

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 7/2

6:10 am-4:20 pm

2 stops10h 10m

Memphis

Sun 7/5

5:10 am-11:25 am

1 stop6h 15m

$362

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 6/4

4:40 pm-11:55 pm

2 stops7h 15m

Memphis

Thu 6/11

5:15 am-11:30 am

1 stop6h 15m

$362
Cheapest one-way

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 8/3

6:38 pm-11:24 pm

1 stop4h 46m

$174

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/20

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Memphis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Memphis in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Memphis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Memphis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Memphis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Memphis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Memphis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Memphis

Have a flexible travel schedule? Discover the best time to fly to Memphis from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Memphis

How much does it cost to fly round-trip from Des Moines to Memphis?

Reviews of airlines servicing Memphis

Get insights into the airlines that provide service to Memphis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Memphis. Reviews last updated April 24, 2026.
See what other customers who have flown with Delta and American Airlines from Des Moines to Memphis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,450 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Crew

8.5

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,450 reviews
Delta
7.9
Good
8,450 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Crew

8.5

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,666 reviews
Delta
7.9
Good
8,450 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Crew

8.5

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Memphis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Memphis?

    Southwest can get you from Des Moines to Memphis in just under 6h 15m. Your travel time can differ by up to . Des Moines and Memphis are separated by a distance of 491 mi.

  • What are the cheapest airlines flying from Des Moines to Memphis round-trip?

    Our cheapest airline available from Des Moines to Memphis is American Airlines. Our recent data shows that you can find tickets from as low as $263 on this airline. An additional option worth looking into is Delta, starting at $263. You may be able to fly from Des Moines to Memphis for 24% less than the average price by searching for these airlines.

  • Can I find deals for flights from Des Moines to Memphis that include hotel bookings?

    Yes. In addition to deals on Des Moines to Memphis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Memphis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Memphis.

  • Can I find deals for business class flights from Des Moines to Memphis?

    Yes. Cheapflights offers flight deals from Des Moines to Memphis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Memphis?

Book flights to Memphis if you plan to visit one of these locations
Southaven
West Memphis
Forrest City
Cordova
Batesville
Marion
Germantown
Horn Lake

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Des Moines to Memphis

Discover the top 2 airlines that operate flights from Des Moines to Memphis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$263Average$326FlexibilityNo cancel feeOn-time71%
DeltaCheapest$263Average$368FlexibilityNo cancel feeOn-timeN/A

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