$191+ Cheap flights from Des Moines (DSM) to Mexico City (MEX)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Oct 21 — Oct 281
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Mexico City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Mexico City
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Cheapest flights from Des Moines to Mexico CityExplore the most affordable flight options available from Des Moines to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 21, 2026.
Explore the most affordable flight options available from Des Moines to Mexico City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 21, 2026.
This Justfly.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:30 pm -
2 stops26h 25m
Mon 11/168:00 am -
1 stop11h 35m
Deal found 9/19![Frontier logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:30 pm -
2 stops26h 45m
Wed 10/1411:55 am -
1 stop29h 47m
Deal found 9/17![Multiple Airlines logo]()
$488
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:30 pm -
1 stop20h 30m
Mon 11/168:00 am -
1 stop11h 35m
Deal found 9/19![Multiple Airlines logo]()
$493
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:25 am -
2 stops33h 50m
Fri 12/411:00 am -
1 stop9h 28m
Deal found 9/18![Multiple Airlines logo]()
$495
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:00 pm -
2 stops33h 40m
Tue 11/1011:00 am -
1 stop26h 55m
Deal found 9/19![Multiple Airlines logo]()
$505
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:30 pm -
1 stop20h 30m
Mon 11/910:50 pm -
2 stops39h 05m
Deal found 9/17![Multiple Airlines logo]()
$532
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/42:45 pm -
1 stop30h 25m
Wed 11/254:00 pm -
2 stops27h 33m
Deal found 9/18![Multiple Airlines logo]()
$534
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/223:57 pm -
2 stops28h 28m
Thu 12/312:05 pm -
1 stop10h 21m
Deal found 9/18![Multiple Airlines logo]()
$554
Best flights from Des Moines to Mexico CityDiscover carefully curated flight deals from Des Moines to Mexico City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 21, 2026.
Discover carefully curated flight deals from Des Moines to Mexico City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 21, 2026.
This Justfly.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:30 pm -
2 stops26h 25m
Mon 11/168:00 am -
1 stop11h 35m
Deal found 9/19![Frontier logo]()
$474
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/911:00 am -
2 stops11h 45m
Mon 11/167:15 pm -
2 stops24h 00m
Deal found 9/19![Delta logo]()
$641
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:27 pm -
1 stop9h 03m
Tue 11/103:30 pm -
1 stop7h 00m
Deal found 9/17![United Airlines logo]()
$657
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:00 am -
2 stops10h 45m
Mon 11/236:40 am -
2 stops14h 00m
Deal found 9/17![Delta logo]()
$641
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/148:00 am -
1 stop10h 55m
Mon 12/217:50 am -
1 stop6h 23m
Deal found 9/16![United Airlines logo]()
$693
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/242:59 pm -
2 stops18h 51m
Fri 12/46:50 am -
2 stops15h 48m
Deal found 9/18![Delta logo]()
$661
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:27 am -
2 stops11h 33m
Thu 11/57:05 am -
2 stops13h 35m
Deal found 9/17![Delta logo]()
$661
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:27 pm -
2 stops10h 43m
Mon 11/237:50 am -
1 stop6h 30m
Deal found 9/19![United Airlines logo]()
$767
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2111:00 am -
2 stops11h 00m
Thu 12/38:40 am -
1 stop9h 26m
Deal found 9/18![Delta logo]()
$721
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2610:57 am -
2 stops12h 48m
Wed 11/46:55 am -
2 stops15h 38m
Deal found 9/20![Delta logo]()
$773
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:45 am -
2 stops23h 10m
Mon 11/237:00 am -
2 stops15h 35m
Deal found 9/18![Delta logo]()
$773
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:35 am -
2 stops10h 25m
Mon 11/97:00 am -
2 stops14h 13m
Deal found 9/16![Delta logo]()
$773
Last-minute flights from Des Moines to Mexico CityDiscover last-minute flight deals from Des Moines to Mexico City. Data last updated September 21, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico City. Data last updated September 21, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/14:20 pm -
2 stops39h 45m
Mon 10/128:40 am -
1 stop9h 50m
Deal found 9/16![Multiple Airlines logo]()
$621
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:30 pm -
2 stops26h 45m
Wed 10/1411:55 am -
1 stop29h 47m
Deal found 9/17![Multiple Airlines logo]()
$488
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/251:57 pm -
2 stops42h 28m
Fri 10/308:00 am -
1 stop10h 35m
Deal found 9/19![Multiple Airlines logo]()
$582
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:25 pm -
1 stop21h 25m
Wed 11/410:35 pm -
2 stops40h 01m
Deal found 9/20![Multiple Airlines logo]()
$579
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:42 pm -
1 stop31h 43m
Tue 11/1011:00 am -
1 stop26h 55m
Deal found 9/17![Multiple Airlines logo]()
$593
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:42 pm -
1 stop31h 43m
Mon 11/910:50 pm -
2 stops39h 05m
Deal found 9/16![Multiple Airlines logo]()
$622
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:00 pm -
2 stops33h 40m
Tue 11/1011:00 am -
1 stop26h 55m
Deal found 9/19![Multiple Airlines logo]()
$505
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:00 pm -
1 stop24h 10m
Thu 11/510:50 pm -
2 stops22h 45m
Deal found 9/17![Multiple Airlines logo]()
$571
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:00 pm -
1 stop24h 10m
Wed 11/410:35 pm -
2 stops20h 59m
Deal found 9/17![Multiple Airlines logo]()
$594
One-way flights from Des Moines to Mexico CitySearch for one-way flight options from Des Moines to Mexico City. Find affordable one-way fares based on user searches. Data last updated September 21, 2026.
Search for one-way flight options from Des Moines to Mexico City. Find affordable one-way fares based on user searches. Data last updated September 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop25h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/1010:07 pm -
1 stop23h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/133:15 pm -
1 stop29h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/49:18 pm -
1 stop22h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:25 am -
2 stops48h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$288
Find flight deals from Des Moines to Mexico City
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Mexico City (MEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $474 (Justfly.com) |
One-way from | $191 (Kiwi.com) |
Popular in | December |
Cheapest in | March |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 21, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Mon 9/28
9:31 pm-8:35 am
2 stops36h 04m
Mexico City Benito Juarez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$198
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Fri 12/4
9:18 pm-8:05 pm
1 stop22h 47m
Mexico City Benito Juarez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$275
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Fri 11/20
7:25 am-10:50 pm
3 stops39h 25m
Mexico City Benito Juarez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$302
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Wed 11/18
5:30 am-10:55 pm
2 stops17h 25m
Mexico City Benito Juarez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$354
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Wed 11/18
11:00 am-9:45 pm
2 stops10h 45m
Mexico City Benito Juarez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$354
Quickest round-trip
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Fri 1/1
3:29 pm-11:14 pm
1 stop7h 45m
Mexico City Benito Juarez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$354
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Mon 1/11
6:20 am-7:05 pm
2 stops12h 45m
Mexico City Benito Juarez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$354
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Sat 10/17
6:00 am-12:45 pm
1 stop7h 45m
Mexico City Benito Juarez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$381
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Mon 11/9
8:30 pm-10:55 pm
2 stops26h 25m
Mexico City Benito Juarez
Mon 11/16
8:00 am-7:35 pm
1 stop11h 35m
$474
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Mon 11/9
11:00 am-10:45 pm
2 stops11h 45m
Mexico City Benito Juarez
Mon 11/16
7:15 pm-7:15 pm
2 stops24h 00m
$641
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Mexico City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Mexico City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Mexico City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Mexico City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Mexico City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Mexico City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Mexico City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Mexico City
Have a flexible travel schedule? Discover the best time to fly to Mexico City from Des Moines with our price prediction graph.
DSM-MEX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Mexico City
Get insights into the airlines that provide service to Mexico City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico City. Reviews last updated September 21, 2026.
Get a feel of what it's like to fly with United Airlines and American Airlines from Des Moines to Mexico City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Overall
7.4
Food
6.7
Boarding
7.7
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Crew
8.1
Overall
7.4
Food
6.7
Boarding
7.7
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Crew
8.1
Overall
7.4
Food
6.7
Boarding
7.7
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Mexico City?
Book flights to Mexico City if you plan to visit one of these locationsTaxco
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Other flights to Mexico City
Explore flights to Mexico City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 21, 2026.
Des Moines and Mexico City flights
Browse other Des Moines and Mexico City flight options. Last updated on September 21, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Des Moines to Mexico City
Discover the top 2 airlines that operate flights from Des Moines to Mexico City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$459 | Average$676 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$536 | Average$666 | FlexibilityNo cancel fee | On-time69% |