HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$161+ Cheap flights from Knoxville to Des Moines (TYS - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
ene. 3 — ene. 101
sáb. 1/3
sáb. 1/10
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Des Moines

Cheapest flights from Knoxville to Des Moines
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 4, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/196:00 amTYS - DSM
1 stop16h 13mAllegiant Air
mar. 12/237:30 amDSM - TYS
1 stop28h 32mAllegiant Air
Deal found 12/4$337
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/67:05 amTYS - DSM
1 stop8h 07mUnited Airlines
lun. 12/82:53 pmDSM - TYS
1 stop7h 51mUnited Airlines
Deal found 12/2$421
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/178:06 amTYS - DSM
1 stop4h 36mAmerican Airlines
dom. 12/213:55 pmDSM - TYS
1 stop4h 26mAmerican Airlines
Deal found 12/2$447
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/54:38 pmTYS - DSM
1 stop7h 57mAmerican Airlines
dom. 12/77:05 amDSM - TYS
1 stop4h 39mAmerican Airlines
Deal found 12/1$459
This United Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/186:45 amTYS - DSM
1 stop5h 05mUnited Airlines
lun. 12/223:14 pmDSM - TYS
2 stops7h 45mUnited Airlines
Deal found 12/3$463
This Mytrip deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/196:00 amTYS - DSM
1 stop16h 13mMultiple Airlines
mar. 12/233:45 pmDSM - TYS
2 stops18h 48mMultiple Airlines
Deal found 12/4$466
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/59:40 amTYS - DSM
2 stops8h 44mUnited Airlines
dom. 12/71:31 pmDSM - TYS
1 stop7h 59mUnited Airlines
Deal found 12/1$485
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/275:23 amTYS - DSM
1 stop6h 24mAmerican Airlines
mar. 12/306:40 amDSM - TYS
1 stop6h 48mAmerican Airlines
Deal found 12/1$509
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/175:54 pmTYS - DSM
1 stop4h 43mUnited Airlines
dom. 12/216:46 pmDSM - TYS
1 stop14h 29mUnited Airlines
Deal found 12/2$548

Find flight deals from Knoxville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated diciembre 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$337
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$323
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
Search Deals
From Knoxville McGhee Tyson to Des Moines
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($96 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($36 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 4, 2025.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Fly from

Knoxville

Fly to

Des Moines

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

mar. 2/17

4:28 pm-10:04 pm

1 stop6h 36m

Des Moines

mar. 2/24

3:26 pm-9:39 pm

1 stop5h 13m

$161

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 1/1

7:48 am-12:54 pm

1 stop6h 06m

Des Moines

dom. 1/4

6:26 pm-11:47 pm

1 stop4h 21m

$329

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

vie. 12/19

6:00 am-9:13 pm

1 stop16h 13m

Des Moines

mar. 12/23

7:30 am-1:02 pm

1 stop28h 32m

$337

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

lun. 1/5

5:35 pm-9:40 pm

1 stop5h 05m

Des Moines

vie. 1/9

8:00 am-1:24 pm

1 stop4h 24m

$363

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

lun. 1/5

5:40 pm-12:37 am

1 stop7h 57m

Des Moines

vie. 1/9

11:35 am-5:42 pm

1 stop5h 07m

$363

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 1/1

5:21 pm-2:00 pm

2 stops21h 39m

Des Moines

dom. 1/4

6:30 pm-8:03 am

1 stop12h 33m

$368

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Compare providers for flights from Knoxville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Des Moines in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Des Moines

What is the cheapest month to book a flight from Knoxville to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $207). Flying from Knoxville to Des Moines in March is currently the most expensive (average of $272). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DSM?

Find hourly flight availability from Knoxville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 4, 2025.

When flying from Knoxville to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 15% versus a flight at noon.

How much does it cost to fly round-trip from Knoxville to Des Moines?

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated diciembre 4, 2025.
Read through reviews of airlines operating flights from Knoxville to Des Moines, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,011 reviews

Food

7.3

Overall

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,011 reviews
Delta
7.9
Good
8,011 reviews

Food

7.3

Overall

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,047 reviews
Delta
7.9
Good
8,011 reviews

Food

7.3

Overall

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Des Moines?

    A quick flight from Knoxville to Des Moines can take about 6h 36m. American Airlines provides one of the quickest options available for as low as $161. The distance from Knoxville to Des Moines is about 654 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Des Moines round-trip?

    Cheapflights users have booked flights from Knoxville to Des Moines round-trip from $248. Another airline that can offer you cheap pricing is American Airlines. Users have found that Delta is 31% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Knoxville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Des Moines.

  • Can I find deals for business class flights from Knoxville to Des Moines?

    Yes. Cheapflights offers flight deals from Knoxville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $207). Flying from Knoxville to Des Moines in March is currently the most expensive (average of $272). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Knoxville to Des Moines

Discover the top 2 airlines that operate flights from Knoxville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$283FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$343FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.