$160+ Cheap flights from Knoxville to Des Moines (TYS - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Aug 22 — Aug 291
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Des Moines
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Cheapest flights from Knoxville to Des MoinesExplore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/109:26 am
TYS
- DSM
1 stop8h 51m
Allegiant Air
Thu 8/135:12 pm
DSM
- TYS
1 stop28h 12m
Allegiant Air
Deal found 7/22![Allegiant Air logo]()
$254
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:02 pm
TYS
- DSM
1 stop4h 21m
United Airlines
Mon 8/3111:32 am
DSM
- TYS
1 stop4h 26m
United Airlines
Deal found 7/20![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:45 pm
TYS
- DSM
2 stops5h 25m
Southwest
Mon 8/315:40 am
DSM
- TYS
2 stops5h 40m
Southwest
Deal found 7/20![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:55 pm
TYS
- DSM
2 stops9h 00m
Southwest
Thu 8/275:40 am
DSM
- TYS
2 stops10h 30m
Southwest
Deal found 7/21![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/174:38 pm
TYS
- DSM
1 stop6h 59m
Delta
Mon 8/245:56 pm
DSM
- TYS
1 stop4h 04m
Delta
Deal found 7/20![Delta logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:56 pm
TYS
- DSM
1 stop7h 35m
Allegiant Air
Mon 8/1012:37 pm
DSM
- TYS
1 stop9h 35m
Allegiant Air
Deal found 7/22![Allegiant Air logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/109:26 am
TYS
- DSM
1 stop8h 51m
Multiple Airlines
Thu 8/135:12 pm
DSM
- TYS
2 stops14h 24m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:45 pm
TYS
- DSM
2 stops5h 25m
Southwest
Mon 8/245:40 am
DSM
- TYS
2 stops10h 30m
Southwest
Deal found 7/20![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:00 am
TYS
- DSM
1 stop4h 26m
United Airlines
Mon 8/241:21 pm
DSM
- TYS
2 stops9h 38m
United Airlines
Deal found 7/20![United Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:52 pm
TYS
- DSM
1 stop6h 28m
American Airlines
Thu 8/134:13 pm
DSM
- TYS
1 stop6h 05m
American Airlines
Deal found 7/21![American Airlines logo]()
$358
Best flights from Knoxville to Des MoinesDiscover carefully curated flight deals from Knoxville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 23, 2026.
Discover carefully curated flight deals from Knoxville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 23, 2026.
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:45 am
TYS
- DSM
2 stops9h 31m
United Airlines
Mon 8/313:20 pm
DSM
- TYS
1 stop4h 33m
United Airlines
Deal found 7/20![United Airlines logo]()
$284
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/174:38 pm
TYS
- DSM
1 stop6h 59m
Delta
Mon 8/245:56 pm
DSM
- TYS
1 stop4h 04m
Delta
Deal found 7/20![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:45 pm
TYS
- DSM
2 stops5h 25m
Southwest
Mon 8/245:40 am
DSM
- TYS
2 stops10h 30m
Southwest
Deal found 7/20![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:00 am
TYS
- DSM
1 stop4h 26m
United Airlines
Mon 8/241:21 pm
DSM
- TYS
2 stops9h 38m
United Airlines
Deal found 7/20![United Airlines logo]()
$343
This deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:02 pm
TYS
- DSM
1 stop4h 31m
United Airlines
Mon 9/213:22 pm
DSM
- TYS
1 stop6h 27m
United Airlines
Deal found 7/18![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/174:50 pm
TYS
- DSM
1 stop7h 43m
United Airlines
Tue 9/226:24 am
DSM
- TYS
2 stops10h 51m
United Airlines
Deal found 7/19![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am
TYS
- DSM
1 stop4h 35m
United Airlines
Mon 11/231:05 pm
DSM
- TYS
1 stop6h 39m
United Airlines
Deal found 7/20![United Airlines logo]()
$463
Last-minute flights from Knoxville to Des MoinesDiscover last-minute flight deals from Knoxville to Des Moines. Data last updated July 23, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Des Moines. Data last updated July 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:56 pm
TYS
- DSM
1 stop7h 35m
Allegiant Air
Mon 8/1012:37 pm
DSM
- TYS
1 stop9h 35m
Allegiant Air
Deal found 7/22![Allegiant Air logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/109:26 am
TYS
- DSM
1 stop8h 51m
Allegiant Air
Thu 8/135:12 pm
DSM
- TYS
1 stop28h 12m
Allegiant Air
Deal found 7/22![Allegiant Air logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/109:26 am
TYS
- DSM
1 stop8h 51m
Multiple Airlines
Thu 8/135:12 pm
DSM
- TYS
2 stops14h 24m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:52 pm
TYS
- DSM
1 stop6h 28m
American Airlines
Thu 8/134:13 pm
DSM
- TYS
1 stop6h 05m
American Airlines
Deal found 7/21![American Airlines logo]()
$358
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/174:38 pm
TYS
- DSM
1 stop6h 59m
Delta
Mon 8/245:56 pm
DSM
- TYS
1 stop4h 04m
Delta
Deal found 7/20![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:45 pm
TYS
- DSM
2 stops5h 25m
Southwest
Mon 8/245:40 am
DSM
- TYS
2 stops10h 30m
Southwest
Deal found 7/20![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:00 am
TYS
- DSM
1 stop4h 26m
United Airlines
Mon 8/241:21 pm
DSM
- TYS
2 stops9h 38m
United Airlines
Deal found 7/20![United Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:02 pm
TYS
- DSM
1 stop4h 21m
United Airlines
Mon 8/3111:32 am
DSM
- TYS
1 stop4h 26m
United Airlines
Deal found 7/20![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:45 pm
TYS
- DSM
2 stops5h 25m
Southwest
Mon 8/315:40 am
DSM
- TYS
2 stops5h 40m
Southwest
Deal found 7/20![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:55 pm
TYS
- DSM
2 stops9h 00m
Southwest
Thu 8/275:40 am
DSM
- TYS
2 stops10h 30m
Southwest
Deal found 7/21![Southwest logo]()
$309
One-way flights from Knoxville to Des MoinesSearch for one-way flight options from Knoxville to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 23, 2026.
Search for one-way flight options from Knoxville to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 23, 2026.
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/174:38 pm
TYS
- DSM
1 stop6h 59m
Delta
Deal found 7/20![Delta logo]()
$160
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/171:00 pm
TYS
- DSM
2 stops10h 10m
Southwest
Deal found 7/20![Southwest logo]()
$195
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/36:32 pm
TYS
- DSM
1 stop6h 29m
American Airlines
Deal found 7/21![American Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:00 am
TYS
- DSM
1 stop5h 17m
United Airlines
Deal found 7/22![United Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3112:35 pm
TYS
- DSM
2 stops12h 00m
Southwest
Deal found 7/22![Southwest logo]()
$350
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3112:53 pm
TYS
- DSM
3 stops28h 16m
Allegiant Air
Deal found 7/22![Allegiant Air logo]()
$508
This Southwest deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:35 pm
TYS
- DSM
2 stops12h 00m
Southwest
Deal found 7/21![Southwest logo]()
$515
Find flight deals from Knoxville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $254 (Kiwi.com) |
One-way from | $160 (Delta) |
Popular in | March |
Cheapest in | February |
Average price | $506 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Mon 8/24
5:45 am-2:16 pm
2 stops9h 31m
Des Moines
Mon 8/31
3:20 pm-8:53 pm
1 stop4h 33m
$284
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Mon 8/17
4:38 pm-10:37 pm
1 stop6h 59m
Des Moines
Mon 8/24
5:56 pm-11:00 pm
1 stop4h 04m
$319
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Mon 8/17
5:45 pm-10:10 pm
2 stops5h 25m
Des Moines
Mon 8/24
5:40 am-5:10 pm
2 stops10h 30m
$339
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Mon 8/17
7:00 am-10:26 am
1 stop4h 26m
Des Moines
Mon 8/24
1:21 pm-11:59 pm
2 stops9h 38m
$343
Quickest round-trip
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Thu 9/17
6:02 pm-9:33 pm
1 stop4h 31m
Des Moines
Mon 9/21
3:22 pm-10:49 pm
1 stop6h 27m
$399
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Thu 9/17
4:50 pm-11:33 pm
1 stop7h 43m
Des Moines
Tue 9/22
6:24 am-6:15 pm
2 stops10h 51m
$404
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Fri 11/20
7:00 am-10:35 am
1 stop4h 35m
Des Moines
Mon 11/23
1:05 pm-8:44 pm
1 stop6h 39m
$463
Cheapest one-way
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Mon 8/17
4:38 pm-10:37 pm
1 stop6h 59m
$160
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Mon 8/3
6:32 pm-12:01 am
1 stop6h 29m
$334
Quickest one-way
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Fri 7/31
6:00 am-10:17 am
1 stop5h 17m
$339
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Des Moines in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.
TYS-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 23, 2026.
Read through reviews of airlines operating flights from Knoxville to Des Moines, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.8
Food
7.2
Comfort
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Entertainment
7.8
Food
7.2
Comfort
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Entertainment
7.8
Food
7.2
Comfort
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Entertainment
7.8
Food
7.2
Comfort
7.8
Overall
7.8
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny
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Knoxville and Des Moines flights
Browse other Knoxville and Des Moines flight options. Last updated on July 23, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on July 23, 2026.
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Top 3 airlines flying from Knoxville to Des Moines
Discover the top 3 airlines that operate flights from Knoxville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$226 | Average$506 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$347 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$284 | Average$396 | FlexibilityNo cancel fee | On-time69% |