$184+ Cheap flights from Knoxville to Des Moines (TYS - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Oct 8 — Oct 151
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Des Moines
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Cheapest flights from Knoxville to Des MoinesExplore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:06 pm -
1 stop8h 25m
Sun 10/46:40 am -
2 stops36h 58m
Deal found 9/4![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:00 am -
2 stops12h 33m
Sun 9/201:58 pm -
1 stop28h 36m
Deal found 9/3![Multiple Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:28 pm -
1 stop4h 18m
Tue 10/65:35 am -
1 stop7h 05m
Deal found 9/8![Delta logo]()
$343
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:22 pm -
1 stop5h 05m
Wed 9/231:30 pm -
1 stop6h 36m
Deal found 9/4![American Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/293:00 pm -
1 stop7h 05m
Mon 10/54:30 pm -
2 stops5h 15m
Deal found 9/4![Southwest logo]()
$348
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:19 pm -
1 stop7h 07m
Sun 11/159:25 am -
1 stop6h 04m
Deal found 9/6![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:05 am -
2 stops8h 10m
Thu 11/125:25 am -
2 stops10h 25m
Deal found 9/4![Southwest logo]()
$365
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
1 stop5h 31m
Tue 10/63:11 pm -
1 stop4h 38m
Deal found 9/7![United Airlines logo]()
$372
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:10 pm -
2 stops10h 45m
Wed 9/2311:32 am -
1 stop4h 26m
Deal found 9/4![United Airlines logo]()
$376
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop5h 31m
Tue 10/61:27 pm -
1 stop7h 47m
Deal found 9/7![United Airlines logo]()
$383
Best flights from Knoxville to Des MoinesDiscover carefully curated flight deals from Knoxville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
Discover carefully curated flight deals from Knoxville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/309:00 am -
1 stop8h 20m
Mon 10/53:11 pm -
1 stop4h 38m
Deal found 9/4![United Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:22 pm -
1 stop5h 05m
Wed 9/231:30 pm -
1 stop6h 36m
Deal found 9/4![American Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:55 pm -
2 stops9h 05m
Mon 10/54:30 pm -
2 stops5h 15m
Deal found 9/4![Southwest logo]()
$353
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 am -
1 stop5h 31m
Mon 10/53:11 pm -
1 stop4h 38m
Deal found 9/5![United Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
1 stop5h 31m
Tue 10/63:11 pm -
1 stop4h 38m
Deal found 9/7![United Airlines logo]()
$372
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:05 am -
2 stops8h 10m
Sun 11/155:25 am -
2 stops14h 05m
Deal found 9/6![Southwest logo]()
$421
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:10 pm -
2 stops10h 45m
Wed 9/2311:32 am -
1 stop4h 26m
Deal found 9/4![United Airlines logo]()
$376
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:51 pm -
1 stop4h 36m
Fri 10/301:27 pm -
1 stop8h 05m
Deal found 9/5![United Airlines logo]()
$463
Last-minute flights from Knoxville to Des MoinesDiscover last-minute flight deals from Knoxville to Des Moines. Data last updated September 8, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Des Moines. Data last updated September 8, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:00 am -
2 stops12h 33m
Sun 9/201:58 pm -
1 stop28h 36m
Deal found 9/3![Multiple Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:22 pm -
1 stop5h 05m
Wed 9/231:30 pm -
1 stop6h 36m
Deal found 9/4![American Airlines logo]()
$347
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:10 pm -
2 stops10h 45m
Wed 9/2311:32 am -
1 stop4h 26m
Deal found 9/4![United Airlines logo]()
$376
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/293:00 pm -
1 stop7h 05m
Mon 10/54:30 pm -
2 stops5h 15m
Deal found 9/4![Southwest logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:06 pm -
1 stop8h 25m
Sun 10/46:40 am -
2 stops36h 58m
Deal found 9/4![Multiple Airlines logo]()
$276
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:28 pm -
1 stop4h 18m
Tue 10/65:35 am -
1 stop7h 05m
Deal found 9/8![Delta logo]()
$343
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop5h 31m
Tue 10/61:27 pm -
1 stop7h 47m
Deal found 9/7![United Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:16 pm -
1 stop6h 25m
Tue 10/69:26 am -
1 stop13h 33m
Deal found 9/8![American Airlines logo]()
$396
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
1 stop5h 31m
Tue 10/63:11 pm -
1 stop4h 38m
Deal found 9/7![United Airlines logo]()
$372
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:49 pm -
1 stop9h 21m
Sun 10/256:37 pm -
1 stop23h 47m
Deal found 9/6![Allegiant Air logo]()
$384
One-way flights from Knoxville to Des MoinesSearch for one-way flight options from Knoxville to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
Search for one-way flight options from Knoxville to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/228:50 pm -
1 stop4h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![American Airlines logo]()
$184
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2212:50 pm -
2 stops11h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Southwest logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/135:38 pm -
1 stop16h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Allegiant Air logo]()
$278
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/138:30 am -
2 stops15h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Southwest logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2211:04 am -
3 stops28h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$406
Find flight deals from Knoxville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $276 (Kiwi.com) |
One-way from | $184 (American Airlines) |
Popular in | March |
Cheapest in | February |
Average price | $317 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Sun 11/22
8:50 pm-12:19 am
1 stop4h 29m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$184
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Sun 11/22
12:50 pm-11:00 pm
2 stops11h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$245
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Sun 9/13
5:38 pm-9:34 am
1 stop16h 56m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$278
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Wed 9/30
9:00 am-4:20 pm
1 stop8h 20m
Des Moines
Mon 10/5
3:11 pm-8:49 pm
1 stop4h 38m
$343
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Fri 10/2
6:00 am-10:31 am
1 stop5h 31m
Des Moines
Mon 10/5
3:11 pm-8:49 pm
1 stop4h 38m
$343
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Sat 9/19
1:22 pm-5:27 pm
1 stop5h 05m
Des Moines
Wed 9/23
1:30 pm-9:06 pm
1 stop6h 36m
$347
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Wed 9/30
1:55 pm-10:00 pm
2 stops9h 05m
Des Moines
Mon 10/5
4:30 pm-10:45 pm
2 stops5h 15m
$353
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Tue 10/6
6:00 am-10:31 am
1 stop5h 31m
Des Moines
Tue 10/6
3:11 pm-8:49 pm
1 stop4h 38m
$372
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Sun 9/13
8:30 am-10:55 pm
2 stops15h 25m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$375
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Sat 9/19
1:10 pm-10:55 pm
2 stops10h 45m
Des Moines
Wed 9/23
11:32 am-4:58 pm
1 stop4h 26m
$376
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.
TYS-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 8, 2026.
Read through reviews of airlines operating flights from Knoxville to Des Moines, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Crew
8.1
Entertainment
7.1
Comfort
7.3
Overall
7.4
Food
6.6
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Boarding
7.7
Crew
8.1
Entertainment
7.1
Comfort
7.3
Overall
7.4
Food
6.6
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Boarding
7.7
Crew
8.1
Entertainment
7.1
Comfort
7.3
Overall
7.4
Food
6.6
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Knoxville and Des Moines flights
Browse other Knoxville and Des Moines flight options. Last updated on September 8, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 8, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Des Moines
Discover the top 2 airlines that operate flights from Knoxville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$226 | Average$513 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$284 | Average$396 | FlexibilityNo cancel fee | On-time69% |