$126+ Cheap flights from Knoxville to Des Moines (TYS - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Nov 23 — Nov 301
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Des Moines
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Cheapest flights from Knoxville to Des MoinesExplore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:50 am -
1 stop5h 08m
Mon 12/78:00 am -
1 stop6h 26m
Deal found 10/20![American Airlines logo]()
$251
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:45 am -
1 stop4h 47m
Thu 11/266:05 am -
2 stops7h 43m
Deal found 10/22![United Airlines logo]()
$256
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:00 pm -
2 stops10h 05m
Thu 11/265:10 am -
2 stops9h 15m
Deal found 10/22![Southwest logo]()
$261
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/32:40 pm -
2 stops8h 25m
Mon 12/76:00 am -
2 stops12h 50m
Deal found 10/23![Southwest logo]()
$274
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:50 am -
1 stop4h 58m
Sun 11/157:06 am -
1 stop7h 12m
Deal found 10/20![American Airlines logo]()
$302
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:45 am -
1 stop6h 35m
Wed 11/111:27 pm -
1 stop8h 05m
Deal found 10/23![United Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:04 am -
1 stop7h 04m
Sat 11/285:30 am -
1 stop4h 58m
Deal found 10/22![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:40 pm -
1 stop5h 15m
Wed 11/111:27 pm -
1 stop8h 05m
Deal found 10/20![United Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/65:40 am -
1 stop6h 09m
Sun 12/1310:30 am -
1 stop6h 52m
Deal found 10/22![Delta logo]()
$353
Best flights from Knoxville to Des MoinesDiscover carefully curated flight deals from Knoxville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
Discover carefully curated flight deals from Knoxville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:45 am -
1 stop4h 47m
Thu 11/266:05 am -
2 stops7h 43m
Deal found 10/22![United Airlines logo]()
$256
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/32:40 pm -
2 stops8h 25m
Mon 12/76:00 am -
2 stops12h 50m
Deal found 10/23![Southwest logo]()
$274
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:50 am -
1 stop4h 58m
Sun 11/157:06 am -
1 stop7h 12m
Deal found 10/20![American Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:50 am -
1 stop5h 08m
Mon 12/78:00 am -
1 stop6h 26m
Deal found 10/24![American Airlines logo]()
$317
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:45 am -
1 stop6h 35m
Wed 11/111:27 pm -
1 stop8h 05m
Deal found 10/23![United Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:40 pm -
1 stop5h 15m
Wed 11/111:27 pm -
1 stop8h 05m
Deal found 10/20![United Airlines logo]()
$351
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:00 am -
1 stop5h 37m
Mon 12/73:20 pm -
2 stops7h 39m
Deal found 10/20![United Airlines logo]()
$356
Last-minute flights from Knoxville to Des MoinesDiscover last-minute flight deals from Knoxville to Des Moines. Data last updated October 24, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Des Moines. Data last updated October 24, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:45 am -
1 stop6h 35m
Wed 11/111:27 pm -
1 stop8h 05m
Deal found 10/23![United Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:40 pm -
1 stop5h 15m
Wed 11/111:27 pm -
1 stop8h 05m
Deal found 10/20![United Airlines logo]()
$351
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:50 am -
1 stop4h 58m
Sun 11/157:06 am -
1 stop7h 12m
Deal found 10/20![American Airlines logo]()
$302
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:45 am -
2 stops8h 43m
Sun 11/158:00 am -
1 stop4h 13m
Deal found 10/20![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:05 pm -
1 stop7h 21m
Thu 11/266:00 am -
1 stop8h 13m
Deal found 10/22![American Airlines logo]()
$251
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:45 am -
1 stop4h 47m
Thu 11/266:05 am -
2 stops7h 43m
Deal found 10/22![United Airlines logo]()
$256
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:00 pm -
2 stops10h 05m
Thu 11/265:10 am -
2 stops9h 15m
Deal found 10/22![Southwest logo]()
$261
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:04 am -
1 stop7h 04m
Sat 11/285:30 am -
1 stop4h 58m
Deal found 10/22![Delta logo]()
$329
One-way flights from Knoxville to Des MoinesSearch for one-way flight options from Knoxville to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
Search for one-way flight options from Knoxville to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:10 pm -
1 stop5h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![American Airlines logo]()
$126
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:45 am -
2 stops8h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![United Airlines logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:03 pm -
1 stop18h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Allegiant Air logo]()
$202
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:55 pm -
2 stops9h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![United Airlines logo]()
$249
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:07 pm -
1 stop6h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![American Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:30 am -
3 stops16h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$332
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/112:50 pm -
2 stops11h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Southwest logo]()
$334
Find flight deals from Knoxville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $251 (American Airlines) |
One-way from | $126 (American Airlines) |
Popular in | March |
Cheapest in | February |
Average price | $561 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Thu 11/12
9:45 am-5:28 pm
2 stops8h 43m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$131
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Fri 11/6
1:55 pm-9:55 pm
2 stops9h 00m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$249
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Thu 11/19
6:45 am-10:32 am
1 stop4h 47m
Des Moines
Thu 11/26
6:05 am-2:48 pm
2 stops7h 43m
$256
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Thu 12/3
2:40 pm-10:05 pm
2 stops8h 25m
Des Moines
Mon 12/7
6:00 am-7:50 pm
2 stops12h 50m
$274
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Thu 11/12
6:50 am-10:48 am
1 stop4h 58m
Des Moines
Sun 11/15
7:06 am-3:18 pm
1 stop7h 12m
$302
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Thu 12/3
6:50 am-10:58 am
1 stop5h 08m
Des Moines
Mon 12/7
8:00 am-3:26 pm
1 stop6h 26m
$317
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Sat 11/7
6:45 am-12:20 pm
1 stop6h 35m
Des Moines
Wed 11/11
1:27 pm-10:32 pm
1 stop8h 05m
$319
Quickest round-trip
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Sun 11/1
6:07 pm-11:57 pm
1 stop6h 50m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$329
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Sun 11/1
12:50 pm-11:00 pm
2 stops11h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$334
KnoxvilleDes Moines
TYS Knoxville McGhee Tyson - DSM Des Moines
TYSDSM
Knoxville McGhee Tyson
Thu 11/12
6:30 am-10:07 pm
3 stops16h 37m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$342
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.
TYS-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 24, 2026.
Read through reviews of airlines operating flights from Knoxville to Des Moines, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.1
Boarding
7.7
Comfort
7.3
Overall
7.3
Crew
8.1
Food
6.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Entertainment
7.1
Boarding
7.7
Comfort
7.3
Overall
7.3
Crew
8.1
Food
6.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Entertainment
7.1
Boarding
7.7
Comfort
7.3
Overall
7.3
Crew
8.1
Food
6.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 24, 2026.
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Knoxville and Des Moines flights
Browse other Knoxville and Des Moines flight options. Last updated on October 24, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on October 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Des Moines
Discover the top 2 airlines that operate flights from Knoxville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$226 | Average$513 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$284 | Average$403 | FlexibilityNo cancel fee | On-time69% |