$154+ Cheap flights from Knoxville to Des Moines (TYS - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Jul 9 — Jul 161
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Des Moines
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Cheapest flights from Knoxville to Des MoinesExplore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 9, 2026.
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/78:35 am
TYS
- DSM
1 stop14h 27m
Allegiant Air
Sun 8/95:12 pm
DSM
- TYS
1 stop28h 12m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/303:38 pm
TYS
- DSM
1 stop6h 49m
Allegiant Air
Fri 7/313:52 pm
DSM
- TYS
1 stop6h 27m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:04 am
TYS
- DSM
1 stop8h 01m
Allegiant Air
Sun 9/131:58 pm
DSM
- TYS
1 stop28h 36m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:30 am
TYS
- DSM
1 stop14h 45m
Allegiant Air
Sat 7/184:59 pm
DSM
- TYS
1 stop29h 04m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:44 pm
TYS
- DSM
1 stop6h 48m
Allegiant Air
Sun 7/1210:57 am
DSM
- TYS
1 stop24h 06m
Allegiant Air
Deal found 6/8![Allegiant Air logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:34 am
TYS
- DSM
1 stop29h 31m
Allegiant Air
Mon 9/144:59 pm
DSM
- TYS
1 stop15h 40m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/48:45 am
TYS
- DSM
1 stop15h 46m
Allegiant Air
Fri 7/104:40 pm
DSM
- TYS
1 stop14h 52m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/23:38 pm
TYS
- DSM
1 stop6h 49m
Allegiant Air
Mon 7/64:40 pm
DSM
- TYS
1 stop22h 30m
Allegiant Air
Deal found 6/9![Allegiant Air logo]()
$294
Best flights from Knoxville to Des MoinesDiscover carefully curated flight deals from Knoxville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 9, 2026.
Discover carefully curated flight deals from Knoxville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:30 am
TYS
- DSM
1 stop14h 45m
Allegiant Air
Sat 7/184:59 pm
DSM
- TYS
1 stop29h 04m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:44 pm
TYS
- DSM
1 stop6h 48m
Multiple Airlines
Sun 7/124:57 pm
DSM
- TYS
2 stops28h 03m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$316
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1312:35 pm
TYS
- DSM
2 stops12h 00m
Southwest
Wed 7/225:20 am
DSM
- TYS
2 stops10h 40m
Southwest
Deal found 6/9![Southwest logo]()
$362
This United Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:00 am
TYS
- DSM
1 stop6h 18m
United Airlines
Mon 8/173:20 pm
DSM
- TYS
1 stop4h 33m
United Airlines
Deal found 6/5![United Airlines logo]()
$425
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:00 am
TYS
- DSM
2 stops8h 30m
Southwest
Fri 7/105:10 am
DSM
- TYS
2 stops15h 05m
Southwest
Deal found 6/5![Southwest logo]()
$364
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:10 am
TYS
- DSM
2 stops8h 55m
Southwest
Wed 7/295:20 am
DSM
- TYS
2 stops10h 40m
Southwest
Deal found 6/7![Southwest logo]()
$367
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3012:35 pm
TYS
- DSM
2 stops12h 00m
Southwest
Fri 7/316:10 am
DSM
- TYS
2 stops14h 05m
Southwest
Deal found 6/5![Southwest logo]()
$379
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1112:30 pm
TYS
- DSM
2 stops10h 40m
Southwest
Sun 9/137:00 am
DSM
- TYS
1 stop9h 15m
Southwest
Deal found 6/6![Southwest logo]()
$408
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/912:35 pm
TYS
- DSM
2 stops12h 00m
Southwest
Sun 7/125:10 am
DSM
- TYS
2 stops9h 35m
Southwest
Deal found 6/8![Southwest logo]()
$423
Last-minute flights from Knoxville to Des MoinesDiscover last-minute flight deals from Knoxville to Des Moines. Data last updated June 9, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Des Moines. Data last updated June 9, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/23:38 pm
TYS
- DSM
1 stop6h 49m
Allegiant Air
Mon 7/64:40 pm
DSM
- TYS
1 stop22h 30m
Allegiant Air
Deal found 6/9![Allegiant Air logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/48:45 am
TYS
- DSM
1 stop15h 46m
Allegiant Air
Fri 7/104:40 pm
DSM
- TYS
1 stop14h 52m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:44 pm
TYS
- DSM
1 stop6h 48m
Allegiant Air
Sun 7/1210:57 am
DSM
- TYS
1 stop24h 06m
Allegiant Air
Deal found 6/8![Allegiant Air logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:44 pm
TYS
- DSM
1 stop6h 48m
Multiple Airlines
Sun 7/124:57 pm
DSM
- TYS
2 stops28h 03m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:30 am
TYS
- DSM
1 stop14h 45m
Allegiant Air
Sat 7/184:59 pm
DSM
- TYS
1 stop29h 04m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:30 am
TYS
- DSM
1 stop14h 45m
Multiple Airlines
Wed 7/222:19 pm
DSM
- TYS
1 stop22h 32m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/303:38 pm
TYS
- DSM
1 stop6h 49m
Allegiant Air
Fri 7/313:52 pm
DSM
- TYS
1 stop6h 27m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$245
One-way flights from Knoxville to Des MoinesSearch for one-way flight options from Knoxville to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 9, 2026.
Search for one-way flight options from Knoxville to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 9, 2026.
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/307:32 am
TYS
- DSM
1 stop8h 19m
American Airlines
Deal found 6/8![American Airlines logo]()
$154
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:45 am
TYS
- DSM
2 stops9h 40m
United Airlines
Deal found 6/8![United Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/143:46 pm
TYS
- DSM
1 stop8h 06m
Allegiant Air
Deal found 6/4![Allegiant Air logo]()
$160
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/266:40 am
TYS
- DSM
1 stop4h 33m
Delta
Deal found 6/8![Delta logo]()
$179
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:45 am
TYS
- DSM
2 stops9h 26m
United Airlines
Deal found 6/8![United Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2210:03 pm
TYS
- DSM
1 stop18h 18m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$218
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:53 pm
TYS
- DSM
1 stop5h 57m
American Airlines
Deal found 6/5![American Airlines logo]()
$219
Find flight deals from Knoxville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $155 (Kiwi.com) |
One-way from | $154 (American Airlines) |
Popular in | March |
Cheapest in | February |
Average price | $456 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 9, 2026.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Mon 7/13
8:30 am-10:15 pm
1 stop14h 45m
Des Moines
Sat 7/18
4:59 pm-11:03 pm
1 stop29h 04m
$265
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Thu 7/9
3:44 pm-9:32 pm
1 stop6h 48m
Des Moines
Sun 7/12
4:57 pm-10:00 pm
2 stops28h 03m
$316
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Mon 7/13
12:35 pm-11:35 pm
2 stops12h 00m
Des Moines
Wed 7/22
5:20 am-5:00 pm
2 stops10h 40m
$362
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Sat 7/4
7:00 am-2:30 pm
2 stops8h 30m
Des Moines
Fri 7/10
5:10 am-9:15 pm
2 stops15h 05m
$364
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Wed 7/22
7:10 am-3:05 pm
2 stops8h 55m
Des Moines
Wed 7/29
5:20 am-5:00 pm
2 stops10h 40m
$367
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Thu 7/30
12:35 pm-11:35 pm
2 stops12h 00m
Des Moines
Fri 7/31
6:10 am-9:15 pm
2 stops14h 05m
$379
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Fri 9/11
12:30 pm-10:10 pm
2 stops10h 40m
Des Moines
Sun 9/13
7:00 am-5:15 pm
1 stop9h 15m
$408
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Thu 7/9
12:35 pm-11:35 pm
2 stops12h 00m
Des Moines
Sun 7/12
5:10 am-3:45 pm
2 stops9h 35m
$423
Quickest round-trip
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Thu 8/13
7:00 am-12:18 pm
1 stop6h 18m
Des Moines
Mon 8/17
3:20 pm-8:53 pm
1 stop4h 33m
$425
Cheapest one-way
KnoxvilleDes Moines
TYS - DSM
TYSDSM
Knoxville McGhee Tyson
Tue 6/30
5:45 am-2:25 pm
2 stops9h 40m
$159
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Des Moines in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.
TYS-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 9, 2026.
Read through reviews of airlines operating flights from Knoxville to Des Moines, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Crew
8.5
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.9
Crew
8.5
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.9
Crew
8.5
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.9
Crew
8.5
Comfort
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 9, 2026.
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Knoxville and Des Moines flights
Browse other Knoxville and Des Moines flight options. Last updated on June 9, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on June 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Des Moines
Discover the top 3 airlines that operate flights from Knoxville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$226 | Average$472 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$338 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$341 | Average$404 | FlexibilityNo cancel fee | On-time69% |