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$166+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
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Cheap flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated July 3, 2025.

Round-trip from

$249
(American Airlines)

One-way from

$166
(Delta)

Popular in

March

Cheapest in

August

Average price

$286
From Knoxville McGhee Tyson to Iowa
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One-way flight from Knoxville McGhee Tyson to Iowa
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Highest demand for flights based on searches. 19% potential increase in price ($86 potential increase over avg. RT price).
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Cheapest flight prices on average. 9% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/246:22 pmTYS - DSM
1 stop6h 27mAmerican Airlines
Wed 7/307:58 amDSM - TYS
1 stop6h 57mAmerican Airlines
Deal found 7/2$249
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/186:30 amTYS - OMA
1 stop7h 28mAmerican Airlines
Mon 9/227:07 amOMA - TYS
1 stop4h 14mAmerican Airlines
Deal found 6/30$249
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/175:30 amTYS - DSM
1 stop6h 09mDelta
Mon 7/217:20 amDSM - TYS
1 stop8h 23mDelta
Deal found 7/2$259
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/256:19 pmTYS - MLI
1 stop5h 00mDelta
Tue 7/295:55 amMLI - TYS
1 stop4h 13mDelta
Deal found 7/2$279
This Mytrip deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/410:05 pmTYS - OMA
1 stop10h 56mAllegiant Air
Thu 8/76:37 pmOMA - TYS
2 stops18h 01mAllegiant Air
Deal found 7/2$279
This Mytrip deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/78:54 pmTYS - DSM
1 stop12h 55mAllegiant Air
Sun 8/106:32 pmDSM - TYS
2 stops23h 39mAllegiant Air
Deal found 7/1$281
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/85:30 amTYS - OMA
1 stop5h 09mDelta
Tue 7/157:00 amOMA - TYS
1 stop8h 43mDelta
Deal found 7/1$284
This Mytrip deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/286:00 amTYS - DSM
2 stops13h 06mMultiple Airlines
Thu 7/317:54 pmDSM - TYS
1 stop10h 56mMultiple Airlines
Deal found 7/2$289
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/166:29 pmTYS - MLI
1 stop6h 07mAmerican Airlines
Sun 7/204:22 pmMLI - TYS
1 stop5h 03mAmerican Airlines
Deal found 6/30$329
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/252:23 pmTYS - LSE
2 stops8h 15mAmerican Airlines
Fri 11/282:52 pmLSE - TYS
1 stop5h 39mAmerican Airlines
Deal found 7/1$443
This United Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/115:45 amTYS - DSM
2 stops9h 56mUnited Airlines
Mon 7/143:38 pmDSM - TYS
1 stop5h 57mUnited Airlines
Deal found 7/3$459
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/167:10 amTYS - MLI
3 stops29h 36mMultiple Airlines
Sun 7/2012:46 pmMLI - TYS
2 stops26h 26mMultiple Airlines
Deal found 6/30$501

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 7/24

6:22 pm-11:49 pm

1 stop6h 27m

Des Moines

Wed 7/30

7:58 am-3:55 pm

1 stop6h 57m

$249

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Thu 9/18

6:30 am-12:58 pm

1 stop7h 28m

Omaha Eppley Airfield

Mon 9/22

7:07 am-12:21 pm

1 stop4h 14m

$249

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 7/17

5:30 am-10:39 am

1 stop6h 09m

Des Moines

Mon 7/21

7:20 am-4:43 pm

1 stop8h 23m

$259

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Mon 8/4

10:05 pm-8:01 am

1 stop10h 56m

Omaha Eppley Airfield

Thu 8/7

6:37 pm-1:38 pm

2 stops18h 01m

$279

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Fri 7/25

6:19 pm-10:19 pm

1 stop5h 00m

Moline Quad-City

Tue 7/29

5:55 am-11:08 am

1 stop4h 13m

$279

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 8/7

8:54 pm-8:49 am

1 stop12h 55m

Des Moines

Sun 8/10

6:32 pm-7:11 pm

2 stops23h 39m

$281

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Mon 7/28

6:00 am-6:06 pm

2 stops13h 06m

Des Moines

Thu 7/31

7:54 pm-7:50 am

1 stop10h 56m

$289

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Wed 7/16

6:29 pm-11:36 pm

1 stop6h 07m

Moline Quad-City

Sun 7/20

4:22 pm-10:25 pm

1 stop5h 03m

$329

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Thu 8/7

5:30 am-9:37 am

1 stop5h 07m

Omaha Eppley Airfield

Sat 8/9

7:00 am-1:54 pm

1 stop5h 54m

$429

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Tue 11/25

2:23 pm-9:38 pm

2 stops8h 15m

La Crosse

Fri 11/28

2:52 pm-9:31 pm

1 stop5h 39m

$443

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Showing 1-10 of 26 results
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $336). Flying from Knoxville to Iowa in June is currently the most expensive (average of $405). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IA?

Find hourly flight availability from Knoxville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

When flying from Knoxville to Iowa, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated July 3, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and Allegiant Air from Knoxville to Iowa to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,861 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.3
Good
708 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.9
Fair
3,286 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • What are the cheapest airlines to fly from Knoxville to Iowa one-way?

    $166 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on Frontier and American Airlines, with prices starting from $177 and $239, respectively.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Des Moines or Knoxville McGhee Tyson - Moline Quad-City.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $336). Flying from Knoxville to Iowa in June is currently the most expensive (average of $405). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$222Average$283FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$332FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$453FlexibilityNo cancel feeOn-time69%

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