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Knoxville

$103+ Cheap flights from Iowa to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
May 18 — May 251
Mon 5/18
Mon 5/25
1 adult, Economy
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Cheap flight deals from Iowa to Knoxville

Cheapest flights from Iowa to Knoxville
Explore the most affordable flight options available from Iowa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
-
TYS
1 stop5h 33m
Allegiant Air
Thu 6/254:05 pm
TYS
-
DSM
1 stop6h 42m
Allegiant Air
Deal found 4/15$241
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
-
TYS
1 stop22h 43m
Multiple Airlines
Thu 6/43:47 pm
TYS
-
DSM
1 stop6h 40m
Multiple Airlines
Deal found 4/14$278
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/28:19 pm
OMA
-
TYS
1 stop22h 14m
Frontier
Fri 6/58:32 pm
TYS
-
OMA
1 stop24h 02m
Frontier
Deal found 4/17$284
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
-
TYS
2 stops29h 56m
Multiple Airlines
Sun 5/313:46 pm
TYS
-
DSM
1 stop7h 45m
Multiple Airlines
Deal found 4/17$288
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:04 pm
CID
-
TYS
1 stop27h 43m
Allegiant Air
Thu 6/259:38 pm
TYS
-
CID
1 stop20h 31m
Allegiant Air
Deal found 4/15$292
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:35 pm
DSM
-
TYS
1 stop7h 44m
United Airlines
Tue 6/96:30 am
TYS
-
DSM
1 stop4h 57m
United Airlines
Deal found 4/16$295
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:17 am
CID
-
TYS
1 stop6h 34m
American Airlines
Wed 7/85:33 pm
TYS
-
CID
1 stop7h 16m
American Airlines
Deal found 4/17$295
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:08 pm
DSM
-
TYS
1 stop27h 52m
Allegiant Air
Sat 7/115:59 pm
TYS
-
DSM
1 stop15h 34m
Allegiant Air
Deal found 4/15$298
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:00 am
DSM
-
TYS
2 stops8h 27m
United Airlines
Tue 6/96:30 am
TYS
-
DSM
1 stop4h 57m
United Airlines
Deal found 4/15$300
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:00 am
CID
-
TYS
1 stop5h 33m
American Airlines
Sat 6/206:07 pm
TYS
-
CID
2 stops6h 23m
American Airlines
Deal found 4/13$300
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:45 am
DSM
-
TYS
1 stop12h 05m
Multiple Airlines
Tue 5/193:48 pm
TYS
-
DSM
2 stops46h 32m
Multiple Airlines
Deal found 4/17$302
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:30 am
DSM
-
TYS
2 stops10h 40m
Southwest
Tue 6/97:10 am
TYS
-
DSM
2 stops8h 55m
Southwest
Deal found 4/16$305

Find flight deals from Iowa to Knoxville

Keep the following information in mind while searching for Iowa to Knoxville flight deals. Data was last updated April 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$241
(Kiwi.com)

One-way from

$103
(Kiwi.com)

Popular in

October

Cheapest in

November

Average price

$415
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
Search Deals
From Iowa to Knoxville McGhee Tyson
Search Deals
One-way flight from Iowa to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 6/2

5:00 am-10:59 am

1 stop4h 59m

Knoxville McGhee Tyson

Tue 6/9

6:07 pm-12:10 am

1 stop7h 03m

$295

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 6/2

1:35 pm-10:19 pm

1 stop7h 44m

Knoxville McGhee Tyson

Tue 6/9

6:30 am-10:27 am

1 stop4h 57m

$295

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 6/3

5:00 am-2:27 pm

2 stops8h 27m

Knoxville McGhee Tyson

Tue 6/9

6:30 am-10:27 am

1 stop4h 57m

$300

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 6/3

5:30 am-5:10 pm

2 stops10h 40m

Knoxville McGhee Tyson

Tue 6/9

2:45 pm-10:45 pm

2 stops9h 00m

$305

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

Wed 5/6

10:39 am-5:08 pm

1 stop5h 29m

Knoxville McGhee Tyson

Thu 5/14

6:01 pm-9:02 pm

1 stop4h 01m

$305

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

Tue 5/5

10:39 am-5:08 pm

1 stop5h 29m

Knoxville McGhee Tyson

Thu 5/14

6:01 pm-9:02 pm

1 stop4h 01m

$305

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Tue 6/16

5:11 am-11:09 am

1 stop4h 58m

Knoxville McGhee Tyson

Tue 6/23

6:05 pm-10:06 pm

1 stop5h 01m

$312

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sat 7/4

4:24 pm-12:02 am

2 stops6h 38m

Knoxville McGhee Tyson

Wed 7/8

5:40 am-11:26 am

2 stops6h 46m

$322

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 6/2

6:50 pm-12:30 am

1 stop4h 40m

Knoxville McGhee Tyson

Fri 6/5

6:30 am-10:27 am

1 stop4h 57m

$326
Quickest round-trip

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Tue 9/1

7:55 am-1:13 pm

1 stop4h 18m

Knoxville McGhee Tyson

Fri 9/4

6:30 am-10:17 am

1 stop4h 47m

$326

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/15

Showing 1-10 of 55 resultsSorted by cheapest first
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Best time to book a flight from Iowa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Knoxville

What is the cheapest month to book a flight from Iowa to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $203). Flying from Iowa to Knoxville in February is currently the most expensive (average of $349). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from Iowa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Iowa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Iowa. McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Iowa to Knoxville?

    American Airlines, United Airlines, and Southwest can get you from Iowa to Knoxville in just under 4h 59m. Your travel time can differ by up to 5h 41m. The distance from Iowa to Knoxville is about 654 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to Knoxville one-way?

    The cheapest airlines for a one-way flight from Iowa to Knoxville are American Airlines ($125), United Airlines ($134), and Delta ($154).

  • What are the most popular routes from Iowa to Knoxville?

    The most popular flight routes from Iowa to Knoxville are Cedar Rapids - Knoxville McGhee Tyson, Des Moines - Knoxville McGhee Tyson and Omaha Eppley Airfield - Knoxville McGhee Tyson.

  • Can I find deals for flights from Iowa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Iowa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Knoxville.

  • Can I find deals for business class flights from Iowa to Knoxville?

    Yes. Cheapflights offers flight deals from Iowa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $203). Flying from Iowa to Knoxville in February is currently the most expensive (average of $349). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge

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Top 3 airlines flying from Iowa to Knoxville

Discover the top 3 airlines that operate flights from Iowa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$353FlexibilityNo cancel feeOn-time71%
DeltaCheapest$203Average$373FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$380FlexibilityNo cancel feeOn-time69%

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