$192+ Cheap flights from Iowa to Knoxville (TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to Knoxville
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Cheapest flights from Iowa to KnoxvilleExplore the most affordable flight options available from Iowa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Iowa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:31 pm -
1 stop7h 09m
Mon 12/78:46 pm -
1 stop4h 47m
Deal found 10/27![American Airlines logo]()
$283
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:53 pm -
1 stop4h 04m
Mon 12/77:26 pm -
1 stop4h 12m
Deal found 10/26![Delta logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:53 pm -
1 stop24h 07m
Thu 11/199:49 pm -
1 stop12h 49m
Deal found 10/27![Allegiant Air logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:53 pm -
1 stop24h 07m
Wed 11/184:02 pm -
1 stop25h 58m
Deal found 10/27![Allegiant Air logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:03 pm -
1 stop13h 42m
Thu 11/199:49 pm -
1 stop12h 49m
Deal found 10/27![Allegiant Air logo]()
$353
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:15 am -
1 stop5h 13m
Fri 11/207:21 pm -
1 stop4h 48m
Deal found 10/27![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:15 am -
1 stop4h 39m
Tue 11/175:10 pm -
2 stops6h 56m
Deal found 10/27![Delta logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:53 pm -
1 stop24h 07m
Sat 11/216:04 pm -
1 stop23h 56m
Deal found 10/27![Allegiant Air logo]()
$361
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:15 am -
2 stops8h 00m
Thu 11/195:10 pm -
2 stops6h 56m
Deal found 10/27![Delta logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:53 pm -
1 stop24h 07m
Fri 11/206:01 pm -
1 stop16h 54m
Deal found 10/27![Allegiant Air logo]()
$365
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/39:30 am -
1 stop6h 30m
Mon 12/72:07 pm -
2 stops8h 18m
Deal found 10/26![United Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:01 pm -
1 stop17h 34m
Thu 11/199:49 pm -
1 stop12h 49m
Deal found 10/27![Allegiant Air logo]()
$369
Best flights from Iowa to KnoxvilleDiscover carefully curated flight deals from Iowa to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Iowa to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:31 pm -
1 stop7h 09m
Mon 12/78:46 pm -
1 stop4h 47m
Deal found 10/29![American Airlines logo]()
$283
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:20 pm -
2 stops7h 39m
Mon 12/75:00 pm -
1 stop6h 21m
Deal found 10/26![United Airlines logo]()
$373
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:15 am -
1 stop3h 40m
Thu 11/195:10 pm -
2 stops6h 56m
Deal found 10/30![Delta logo]()
$374
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:00 am -
1 stop8h 10m
Wed 11/181:00 pm -
2 stops10h 05m
Deal found 10/30![Southwest logo]()
$392
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:23 am -
1 stop4h 36m
Wed 11/183:45 pm -
1 stop7h 45m
Deal found 10/30![United Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:00 am -
1 stop5h 12m
Sat 11/147:05 pm -
1 stop5h 31m
Deal found 10/26![American Airlines logo]()
$387
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:15 am -
1 stop5h 13m
Fri 11/207:10 am -
2 stops9h 58m
Deal found 10/27![Delta logo]()
$389
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:00 am -
2 stops12h 50m
Mon 12/77:05 am -
2 stops8h 10m
Deal found 10/26![Southwest logo]()
$398
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/156:30 pm -
1 stop4h 16m
Sat 4/2411:30 am -
1 stop6h 20m
Deal found 10/28![Delta logo]()
$397
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/116:10 am -
2 stops7h 34m
Sat 2/136:15 am -
3 stops13h 28m
Deal found 10/30![United Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:15 am -
1 stop6h 02m
Tue 11/176:01 am -
2 stops7h 20m
Deal found 10/29![American Airlines logo]()
$427
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:15 am -
1 stop3h 40m
Sat 11/142:40 pm -
2 stops9h 26m
Deal found 10/28![Delta logo]()
$404
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3011:00 am -
1 stop4h 54m
Wed 2/35:55 pm -
1 stop5h 55m
Deal found 10/29![United Airlines logo]()
$439
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/162:15 pm -
1 stop5h 25m
Fri 4/237:20 pm -
1 stop4h 09m
Deal found 10/28![Delta logo]()
$407
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/114:00 pm -
1 stop4h 37m
Sat 2/138:47 am -
1 stop4h 26m
Deal found 10/30![Delta logo]()
$427
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:15 am -
1 stop5h 13m
Sun 11/157:22 pm -
1 stop4h 47m
Deal found 10/26![Delta logo]()
$434
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/911:24 am -
1 stop4h 35m
Fri 11/135:40 pm -
1 stop25h 27m
Deal found 10/25![United Airlines logo]()
$597
Last-minute flights from Iowa to KnoxvilleDiscover last-minute flight deals from Iowa to Knoxville. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Knoxville. Data last updated October 30, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:01 pm -
1 stop17h 34m
Thu 11/199:49 pm -
1 stop12h 49m
Deal found 10/27![Allegiant Air logo]()
$369
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:00 pm -
1 stop5h 11m
Tue 11/176:30 pm -
1 stop5h 36m
Deal found 10/27![Delta logo]()
$354
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:00 am -
1 stop5h 12m
Sat 11/147:05 pm -
1 stop5h 31m
Deal found 10/26![American Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:24 pm -
2 stops7h 35m
Sat 11/146:45 am -
1 stop6h 35m
Deal found 10/26![United Airlines logo]()
$392
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:03 pm -
1 stop13h 42m
Thu 11/199:49 pm -
1 stop12h 49m
Deal found 10/27![Allegiant Air logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:53 pm -
1 stop24h 07m
Thu 11/199:49 pm -
1 stop12h 49m
Deal found 10/27![Allegiant Air logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:53 pm -
1 stop24h 07m
Wed 11/184:02 pm -
1 stop25h 58m
Deal found 10/27![Allegiant Air logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:53 pm -
1 stop24h 07m
Sat 11/216:04 pm -
1 stop23h 56m
Deal found 10/27![Allegiant Air logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:53 pm -
1 stop24h 07m
Fri 11/206:01 pm -
1 stop16h 54m
Deal found 10/27![Allegiant Air logo]()
$365
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:30 am -
1 stop27h 09m
Tue 11/178:30 am -
1 stop29h 35m
Deal found 10/29![Allegiant Air logo]()
$397
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:15 am -
1 stop4h 39m
Tue 11/175:10 pm -
2 stops6h 56m
Deal found 10/27![Delta logo]()
$359
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:15 am -
2 stops8h 00m
Thu 11/195:10 pm -
2 stops6h 56m
Deal found 10/27![Delta logo]()
$364
One-way flights from Iowa to KnoxvilleSearch for one-way flight options from Iowa to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Iowa to Knoxville. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:06 am -
1 stop7h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![American Airlines logo]()
$192
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1511:36 am -
1 stop5h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![Delta logo]()
$244
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/307:58 pm -
1 stop14h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![American Airlines logo]()
$253
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:05 am -
2 stops7h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![United Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/304:19 pm -
2 stops26h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Allegiant Air logo]()
$279
This deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:00 am -
1 stop6h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![United Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/308:13 pm -
3 stops23h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Multiple Airlines logo]()
$484
Find flight deals from Iowa to Knoxville
Keep the following information in mind while searching for Iowa to Knoxville flight deals. Data was last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $283 (American Airlines) |
One-way from | $192 (American Airlines) |
Popular in | September |
Cheapest in | August |
Average price | $472 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Sun 11/15
7:06 am-3:18 pm
1 stop7h 12m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$192
Quickest round-trip
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Sun 11/15
11:36 am-6:27 pm
1 stop5h 51m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$244
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Sun 11/15
6:05 am-2:48 pm
2 stops7h 43m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$275
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Wed 12/30
4:19 pm-8:18 pm
2 stops26h 59m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$279
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Fri 12/4
3:31 pm-11:40 pm
1 stop7h 09m
Knoxville McGhee Tyson
Mon 12/7
8:46 pm-12:33 am
1 stop4h 47m
$283
Cedar RapidsKnoxville
CID Cedar Rapids - TYS Knoxville McGhee Tyson
CIDTYS
Cedar Rapids
Sat 11/21
6:00 am-1:13 pm
1 stop6h 13m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$339
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Fri 12/4
3:20 pm-11:59 pm
2 stops7h 39m
Knoxville McGhee Tyson
Mon 12/7
5:00 pm-10:21 pm
1 stop6h 21m
$373
Cedar RapidsKnoxville
CID Cedar Rapids - TYS Knoxville McGhee Tyson
CIDTYS
Cedar Rapids
Fri 11/13
5:15 am-9:55 am
1 stop3h 40m
Knoxville McGhee Tyson
Thu 11/19
5:10 pm-11:06 pm
2 stops6h 56m
$374
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Sat 11/14
11:23 am-4:59 pm
1 stop4h 36m
Knoxville McGhee Tyson
Wed 11/18
3:45 pm-10:30 pm
1 stop7h 45m
$387
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Tue 11/10
6:00 am-12:12 pm
1 stop5h 12m
Knoxville McGhee Tyson
Sat 11/14
7:05 pm-11:36 pm
1 stop5h 31m
$387
Showing 1-10 of 22 resultsSorted by cheapest first
Best time to book a flight from Iowa to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Iowa with our price prediction graph.
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Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Knoxville
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What is the cheapest month to book a flight from Iowa to Knoxville?
Currently, January is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $265). Flying from Iowa to Knoxville in October is currently the most expensive (average of $490). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Iowa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Morristown
Newport
Bryson City
Crossville
Murphy
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Alternative routes for Iowa to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to Knoxville by cabin class
Find flights from Iowa to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Iowa and Knoxville flights
Browse other Iowa and Knoxville flight options. Last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Iowa to Knoxville flights
Consider these flights traveling from Iowa to Knoxville.
Top 3 airlines flying from Iowa to Knoxville
Discover the top 3 airlines that operate flights from Iowa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$387 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$251 | Average$362 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$294 | Average$408 | FlexibilityNo cancel fee | On-timeN/A |