$112+ Cheap flights from Iowa to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Oct 1 — Oct 81
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to Knoxville
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Cheapest flights from Iowa to KnoxvilleExplore the most affordable flight options available from Iowa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 1, 2026.
Explore the most affordable flight options available from Iowa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:09 pm -
1 stop21h 19m
Sun 11/110:34 am -
1 stop8h 33m
Deal found 8/30![Allegiant Air logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:58 pm -
1 stop27h 36m
Sun 9/135:38 pm -
1 stop16h 56m
Deal found 8/27![Allegiant Air logo]()
$269
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:50 am -
1 stop6h 53m
Sat 10/106:55 pm -
1 stop6h 25m
Deal found 8/30![American Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/712:40 pm -
1 stop23h 27m
Thu 12/109:00 pm -
1 stop15h 50m
Deal found 8/30![Allegiant Air logo]()
$303
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:00 am -
1 stop4h 50m
Sat 9/122:00 pm -
1 stop6h 18m
Deal found 8/31![American Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:46 pm -
1 stop14h 27m
Wed 10/76:41 pm -
1 stop14h 13m
Deal found 8/30![Allegiant Air logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:58 pm -
1 stop27h 36m
Mon 9/148:00 am -
2 stops12h 33m
Deal found 8/27![Multiple Airlines logo]()
$307
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:32 am -
1 stop4h 00m
Wed 10/1410:29 am -
1 stop7h 08m
Deal found 8/31![Delta logo]()
$308
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:40 am -
1 stop4h 04m
Sat 9/125:40 am -
2 stops6h 42m
Deal found 8/31![Delta logo]()
$310
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:13 pm -
1 stop4h 46m
Sat 10/3111:35 am -
1 stop6h 49m
Deal found 8/30![American Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:00 am -
2 stops7h 49m
Wed 11/115:10 pm -
2 stops6h 56m
Deal found 8/29![Delta logo]()
$315
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:30 am -
1 stop4h 24m
Sat 10/315:40 am -
2 stops8h 03m
Deal found 8/30![Delta logo]()
$317
Best flights from Iowa to KnoxvilleDiscover carefully curated flight deals from Iowa to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 1, 2026.
Discover carefully curated flight deals from Iowa to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:58 pm -
1 stop27h 36m
Sun 9/135:38 pm -
1 stop16h 56m
Deal found 8/27![Allegiant Air logo]()
$269
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:00 am -
2 stops7h 49m
Wed 11/115:10 pm -
2 stops6h 56m
Deal found 8/29![Delta logo]()
$315
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:00 am -
1 stop4h 05m
Sat 10/3111:35 am -
1 stop5h 57m
Deal found 8/28![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:27 am -
1 stop4h 41m
Tue 10/271:56 pm -
1 stop4h 31m
Deal found 8/29![United Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:30 am -
2 stops10h 20m
Thu 11/128:10 am -
2 stops11h 45m
Deal found 8/30![Southwest logo]()
$408
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:46 pm -
1 stop14h 27m
Wed 10/76:41 pm -
1 stop14h 13m
Deal found 8/30![Allegiant Air logo]()
$307
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:16 pm -
1 stop4h 11m
Wed 10/710:29 am -
1 stop6h 55m
Deal found 8/27![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:57 pm -
1 stop4h 45m
Wed 10/76:05 pm -
2 stops7h 06m
Deal found 8/27![American Airlines logo]()
$324
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:30 am -
1 stop4h 15m
Mon 11/97:22 pm -
1 stop4h 47m
Deal found 8/28![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:24 am -
2 stops7h 13m
Sat 9/196:00 am -
1 stop5h 36m
Deal found 8/31![United Airlines logo]()
$352
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:03 pm -
1 stop5h 44m
Tue 12/156:48 am -
2 stops10h 40m
Deal found 8/31![American Airlines logo]()
$324
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:22 pm -
1 stop6h 27m
Mon 9/146:00 am -
1 stop7h 16m
Deal found 8/27![United Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:03 pm -
1 stop5h 56m
Tue 10/206:05 pm -
2 stops7h 06m
Deal found 8/30![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:25 am -
1 stop4h 53m
Wed 9/2310:26 am -
1 stop7h 08m
Deal found 8/31![Delta logo]()
$349
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:35 am -
2 stops5h 45m
Fri 9/182:05 pm -
1 stop8h 00m
Deal found 8/30![Southwest logo]()
$452
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:57 pm -
1 stop4h 45m
Tue 9/1511:20 am -
1 stop6h 07m
Deal found 8/27![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/269:03 am -
1 stop7h 00m
Sat 1/301:55 pm -
1 stop4h 59m
Deal found 8/30![United Airlines logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:00 am -
1 stop15h 23m
Sun 10/189:25 am -
1 stop14h 45m
Deal found 8/27![Allegiant Air logo]()
$424
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:30 pm -
1 stop5h 25m
Thu 9/248:55 am -
1 stop4h 44m
Deal found 9/1![Delta logo]()
$367
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:30 am -
2 stops8h 25m
Sat 9/196:50 am -
1 stop3h 40m
Deal found 8/30![Southwest logo]()
$452
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 am -
2 stops10h 36m
Sat 9/193:53 pm -
2 stops9h 12m
Deal found 8/31![American Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/161:36 pm -
2 stops9h 23m
Wed 9/236:00 pm -
1 stop6h 04m
Deal found 8/30![United Airlines logo]()
$403
This Southwest deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:00 pm -
2 stops5h 45m
Mon 10/2612:50 pm -
2 stops8h 30m
Deal found 8/29![Southwest logo]()
$468
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:09 pm -
1 stop5h 46m
Mon 10/57:25 pm -
1 stop4h 05m
Deal found 8/29![Delta logo]()
$388
This United Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:32 am -
1 stop4h 26m
Sun 9/206:00 am -
1 stop5h 31m
Deal found 8/30![United Airlines logo]()
$405
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:00 am -
2 stops9h 15m
Tue 9/151:10 pm -
2 stops9h 18m
Deal found 8/27![United Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:10 pm -
2 stops9h 17m
Sat 10/106:23 pm -
1 stop4h 33m
Deal found 8/30![Delta logo]()
$447
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:07 am -
2 stops9h 14m
Mon 10/196:55 pm -
1 stop6h 25m
Deal found 8/27![American Airlines logo]()
$453
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:27 pm -
1 stop8h 05m
Fri 11/275:40 pm -
1 stop5h 15m
Deal found 8/31![United Airlines logo]()
$423
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:11 pm -
2 stops7h 48m
Sun 9/136:00 am -
1 stop5h 22m
Deal found 8/27![United Airlines logo]()
$424
Last-minute flights from Iowa to KnoxvilleDiscover last-minute flight deals from Iowa to Knoxville. Data last updated September 1, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to Knoxville. Data last updated September 1, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:00 am -
1 stop4h 50m
Sat 9/122:00 pm -
1 stop6h 18m
Deal found 8/31![American Airlines logo]()
$305
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:40 am -
1 stop4h 04m
Sat 9/125:40 am -
2 stops6h 42m
Deal found 8/31![Delta logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:58 pm -
1 stop27h 36m
Sun 9/135:38 pm -
1 stop16h 56m
Deal found 8/27![Allegiant Air logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:58 pm -
1 stop27h 36m
Mon 9/148:00 am -
2 stops12h 33m
Deal found 8/27![Multiple Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:58 pm -
2 stops21h 43m
Sun 9/135:38 pm -
1 stop16h 56m
Deal found 8/27![Multiple Airlines logo]()
$337
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:40 am -
1 stop6h 41m
Sat 9/266:20 am -
1 stop6h 02m
Deal found 8/30![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:53 pm -
1 stop4h 13m
Sat 10/38:14 pm -
1 stop4h 51m
Deal found 8/27![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:50 am -
1 stop6h 53m
Sat 10/106:55 pm -
1 stop6h 25m
Deal found 8/30![American Airlines logo]()
$303
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:32 am -
1 stop4h 00m
Wed 10/1410:29 am -
1 stop7h 08m
Deal found 8/31![Delta logo]()
$308
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:13 pm -
1 stop4h 46m
Sat 10/3111:35 am -
1 stop6h 49m
Deal found 8/30![American Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:30 am -
1 stop4h 24m
Sat 10/315:40 am -
2 stops8h 03m
Deal found 8/30![Delta logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:09 pm -
1 stop21h 19m
Sun 11/110:34 am -
1 stop8h 33m
Deal found 8/30![Allegiant Air logo]()
$260
One-way flights from Iowa to KnoxvilleSearch for one-way flight options from Iowa to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 1, 2026.
Search for one-way flight options from Iowa to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/271:58 pm -
1 stop28h 36m
Deal found 8/29![Allegiant Air logo]()
$112
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:03 pm -
1 stop6h 19m
Deal found 8/27![Delta logo]()
$144
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/211:24 pm -
2 stops9h 35m
Deal found 8/27![United Airlines logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:47 pm -
1 stop25h 10m
Deal found 8/27![Allegiant Air logo]()
$196
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:00 am -
2 stops7h 42m
Deal found 8/29![United Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:10 pm -
2 stops41h 54m
Deal found 8/28![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:10 pm -
1 stop13h 04m
Deal found 8/28![Allegiant Air logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/271:58 pm -
3 stops25h 45m
Deal found 8/29![Multiple Airlines logo]()
$243
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:54 pm -
1 stop4h 05m
Deal found 8/31![Delta logo]()
$260
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1011:22 am -
1 stop5h 14m
Deal found 8/31![American Airlines logo]()
$270
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:30 am -
1 stop4h 24m
Deal found 8/31![Delta logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:25 pm -
2 stops43h 56m
Deal found 8/31![Multiple Airlines logo]()
$296
Find flight deals from Iowa to Knoxville
Keep the following information in mind while searching for Iowa to Knoxville flight deals. Data was last updated September 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $260 (Kiwi.com) |
One-way from | $112 (Kiwi.com) |
Popular in | September |
Cheapest in | November |
Average price | $488 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 1, 2026.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Thu 9/10
1:58 pm-6:34 pm
1 stop27h 36m
Knoxville McGhee Tyson
Sun 9/13
5:38 pm-9:34 am
1 stop16h 56m
$269
MolineKnoxville
MLI Moline Quad-City - TYS Knoxville McGhee Tyson
MLITYS
Moline Quad-City
Sat 10/3
4:46 pm-8:13 am
1 stop14h 27m
Knoxville McGhee Tyson
Wed 10/7
6:41 pm-7:54 am
1 stop14h 13m
$307
Cedar RapidsKnoxville
CID Cedar Rapids - TYS Knoxville McGhee Tyson
CIDTYS
Cedar Rapids
Sat 11/7
11:00 am-7:49 pm
2 stops7h 49m
Knoxville McGhee Tyson
Wed 11/11
5:10 pm-11:06 pm
2 stops6h 56m
$315
MolineKnoxville
MLI Moline Quad-City - TYS Knoxville McGhee Tyson
MLITYS
Moline Quad-City
Sun 10/25
6:00 am-11:05 am
1 stop4h 05m
Knoxville McGhee Tyson
Sat 10/31
11:35 am-4:32 pm
1 stop5h 57m
$319
MolineKnoxville
MLI Moline Quad-City - TYS Knoxville McGhee Tyson
MLITYS
Moline Quad-City
Sat 10/3
5:16 pm-10:27 pm
1 stop4h 11m
Knoxville McGhee Tyson
Wed 10/7
10:29 am-4:24 pm
1 stop6h 55m
$319
Quickest round-trip
Cedar RapidsKnoxville
CID Cedar Rapids - TYS Knoxville McGhee Tyson
CIDTYS
Cedar Rapids
Mon 11/2
5:30 am-10:45 am
1 stop4h 15m
Knoxville McGhee Tyson
Mon 11/9
7:22 pm-11:09 pm
1 stop4h 47m
$319
MolineKnoxville
MLI Moline Quad-City - TYS Knoxville McGhee Tyson
MLITYS
Moline Quad-City
Sat 10/3
4:57 pm-10:42 pm
1 stop4h 45m
Knoxville McGhee Tyson
Wed 10/7
6:05 pm-12:11 am
2 stops7h 06m
$324
MolineKnoxville
MLI Moline Quad-City - TYS Knoxville McGhee Tyson
MLITYS
Moline Quad-City
Thu 12/10
5:03 pm-11:47 pm
1 stop5h 44m
Knoxville McGhee Tyson
Tue 12/15
6:48 am-4:28 pm
2 stops10h 40m
$324
MolineKnoxville
MLI Moline Quad-City - TYS Knoxville McGhee Tyson
MLITYS
Moline Quad-City
Wed 10/14
5:03 pm-11:59 pm
1 stop5h 56m
Knoxville McGhee Tyson
Tue 10/20
6:05 pm-12:11 am
2 stops7h 06m
$339
Des MoinesKnoxville
DSM Des Moines - TYS Knoxville McGhee Tyson
DSMTYS
Des Moines
Sat 10/24
11:27 am-5:08 pm
1 stop4h 41m
Knoxville McGhee Tyson
Tue 10/27
1:56 pm-5:27 pm
1 stop4h 31m
$347
Showing 1-10 of 54 resultsSorted by cheapest first
Best time to book a flight from Iowa to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Iowa with our price prediction graph.
DSM-TYS
CID-TYS
MLI-TYS
OMA-TYS
SUX-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to Knoxville
USIA-TYS
DSM-TYS
CID-TYS
MLI-TYS
OMA-TYS
What is the cheapest month to book a flight from Iowa to Knoxville?
Currently, January is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $265). Flying from Iowa to Knoxville in October is currently the most expensive (average of $546). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to Knoxville?
Airfare is below average for this route at the moment.
Iowa to Knoxville flights typically cost between $380 and $677 in September.The cheapest round-trip price found within the last 5 days was $269 on Allegiant Air (Sep 10-Sep 13).
Related info for your journey
Find useful and relevant information for your journey from Iowa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Iowa to Knoxville
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Complete your trip
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 1, 2026.
Iowa and Knoxville flights
Browse other Iowa and Knoxville flight options. Last updated on September 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Iowa to Knoxville flights
Consider these flights traveling from Iowa to Knoxville.
Top 3 airlines flying from Iowa to Knoxville
Discover the top 3 airlines that operate flights from Iowa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$203 | Average$355 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$203 | Average$405 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$387 | FlexibilityNo cancel fee | On-time69% |