HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$99+ Cheap flights from Iowa to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Jul 31 — Aug 71
Fri 7/31
Fri 8/7
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to Knoxville

Cheapest flights from Iowa to Knoxville
Explore the most affordable flight options available from Iowa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2026.

This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:08 pm
DSM
-
TYS
1 stop27h 52m
Allegiant Air
Sun 7/263:38 pm
TYS
-
DSM
1 stop8h 09m
Allegiant Air
Deal found 6/29$228
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1012:37 pm
DSM
-
TYS
1 stop9h 35m
Allegiant Air
Mon 8/171:36 pm
TYS
-
DSM
1 stop23h 27m
Allegiant Air
Deal found 6/28$254
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/14:47 pm
DSM
-
TYS
1 stop5h 57m
Delta
Sat 8/86:35 am
TYS
-
DSM
1 stop4h 43m
Delta
Deal found 6/29$279
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:33 pm
OMA
-
TYS
1 stop4h 19m
Delta
Tue 7/285:40 am
TYS
-
OMA
1 stop4h 48m
Delta
Deal found 6/28$279
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:55 pm
CID
-
TYS
1 stop21h 15m
Allegiant Air
Thu 7/163:53 pm
TYS
-
CID
1 stop17h 09m
Allegiant Air
Deal found 6/27$280
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:08 pm
DSM
-
TYS
1 stop27h 52m
Allegiant Air
Sat 7/255:59 pm
TYS
-
DSM
1 stop15h 34m
Allegiant Air
Deal found 6/29$281
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/811:32 am
DSM
-
TYS
1 stop4h 26m
United Airlines
Sat 9/125:45 am
TYS
-
DSM
2 stops7h 31m
United Airlines
Deal found 7/1$284
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:25 pm
OMA
-
TYS
1 stop4h 58m
United Airlines
Tue 9/295:45 am
TYS
-
OMA
2 stops7h 29m
United Airlines
Deal found 6/30$284
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:15 am
OMA
-
TYS
1 stop4h 26m
American Airlines
Mon 10/58:37 pm
TYS
-
OMA
1 stop4h 32m
American Airlines
Deal found 6/26$285
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/171:37 pm
DSM
-
TYS
1 stop8h 11m
Allegiant Air
Thu 7/233:38 pm
TYS
-
DSM
1 stop6h 49m
Allegiant Air
Deal found 6/29$287
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:30 am
DSM
-
TYS
2 stops11h 10m
Southwest
Sat 8/221:55 pm
TYS
-
DSM
1 stop7h 50m
Southwest
Deal found 6/28$290
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:55 pm
CID
-
TYS
1 stop13h 37m
Allegiant Air
Fri 7/2410:05 pm
TYS
-
CID
1 stop13h 32m
Allegiant Air
Deal found 6/29$292

Find flight deals from Iowa to Knoxville

Keep the following information in mind while searching for Iowa to Knoxville flight deals. Data was last updated July 1, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$228
(Kiwi.com)

One-way from

$99
(Kiwi.com)

Popular in

September

Cheapest in

November

Average price

$356
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
Search Deals
From Iowa to Knoxville McGhee Tyson
Search Deals
One-way flight from Iowa to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($72 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2026.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 8/10

12:37 pm-11:12 pm

1 stop9h 35m

Knoxville McGhee Tyson

Mon 8/17

1:36 pm-12:03 pm

1 stop23h 27m

$254

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 9/8

4:11 pm-10:27 pm

1 stop5h 16m

Knoxville McGhee Tyson

Sat 9/12

11:40 am-3:15 pm

1 stop4h 35m

$279

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 8/1

4:47 pm-11:44 pm

1 stop5h 57m

Knoxville McGhee Tyson

Sat 8/8

6:35 am-10:18 am

1 stop4h 43m

$279

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Tue 7/21

6:33 pm-11:52 pm

1 stop4h 19m

Knoxville McGhee Tyson

Sat 7/25

6:40 am-10:29 am

1 stop4h 49m

$279

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Tue 9/22

6:25 pm-12:23 am

1 stop4h 58m

Knoxville McGhee Tyson

Tue 9/29

5:45 am-12:14 pm

2 stops7h 29m

$284

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 9/8

6:10 am-6:55 pm

2 stops11h 45m

Knoxville McGhee Tyson

Sat 9/12

6:50 am-2:10 pm

2 stops8h 20m

$295

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 8/15

5:30 am-5:40 pm

2 stops11h 10m

Knoxville McGhee Tyson

Sat 8/22

6:50 am-2:10 pm

2 stops8h 20m

$295

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 9/30

7:15 am-4:30 pm

1 stop8h 15m

Knoxville McGhee Tyson

Mon 10/5

1:50 pm-9:55 pm

2 stops9h 05m

$304

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Tue 8/4

6:00 am-2:27 pm

2 stops7h 27m

Knoxville McGhee Tyson

Sat 8/8

6:00 am-10:27 am

1 stop5h 27m

$306

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Thu 10/29

5:30 am-11:01 am

1 stop4h 31m

Knoxville McGhee Tyson

Sun 11/1

6:21 pm-10:06 pm

1 stop4h 45m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/29

Showing 1-10 of 43 resultsSorted by cheapest first
1
2
3
...
5

Best time to book a flight from Iowa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Knoxville

What is the cheapest month to book a flight from Iowa to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $203). Flying from Iowa to Knoxville in June is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to Knoxville?

Related info for your journey

Find useful and relevant information for your journey from Iowa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Iowa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Iowa. McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Iowa to Knoxville?

    Allegiant Air, Delta, and United Airlines can get you from Iowa to Knoxville in just under 4h 58m. Your travel time can differ by up to 4h 37m. The distance from Iowa to Knoxville is about 745 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Iowa to Knoxville?

    The most popular flight routes from Iowa to Knoxville are Cedar Rapids - Knoxville McGhee Tyson, Omaha Eppley Airfield - Knoxville McGhee Tyson and Des Moines - Knoxville McGhee Tyson.

  • Can I find deals for flights from Iowa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Iowa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Knoxville.

  • Can I find deals for business class flights from Iowa to Knoxville?

    Yes. Cheapflights offers flight deals from Iowa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $203). Flying from Iowa to Knoxville in June is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to Nashville flights
Newark to Nashville flights
John F Kennedy Intl to Nashville flights
Boston to Nashville flights
Philadelphia to Nashville flights
LaGuardia to Nashville flights
Seattle to Nashville flights
Reagan-National to Nashville flights
Dallas/Fort Worth to Nashville flights
O'Hare Intl to Nashville flights
Denver to Nashville flights
Baltimore to Nashville flights
San Francisco to Nashville flights
Raleigh to Nashville flights
Dulles Intl to Nashville flights
Ontario to Nashville flights
Sky Harbor Intl to Nashville flights
Austin to Nashville flights
LaGuardia to Knoxville flights
Minneapolis to Nashville flights
Hobby to Nashville flights
George Bush Intcntl to Nashville flights
San Diego to Nashville flights
Orlando to Nashville flights
Tampa to Nashville flights
Cleveland to Nashville flights
O'Hare Intl to Knoxville flights
Portland to Nashville flights
Miami to Nashville flights
Fort Lauderdale to Nashville flights
John F Kennedy Intl to Knoxville flights
George Bush Intcntl to Knoxville flights
West Palm Beach to Nashville flights
Sacramento to Nashville flights
Hartford to Nashville flights
Burbank to Nashville flights
Detroit to Nashville flights
LaGuardia to Memphis flights
Dallas/Fort Worth to Knoxville flights
Newark to Memphis flights
Salt Lake City to Nashville flights
Hobby to Knoxville flights
Minneapolis to Knoxville flights
Los Angeles to Memphis flights
Providence to Nashville flights
Denver to Knoxville flights
Milwaukee to Nashville flights
Charlotte to Nashville flights
New Orleans to Nashville flights
O'Hare Intl to Memphis flights

Top 3 airlines flying from Iowa to Knoxville

Discover the top 3 airlines that operate flights from Iowa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$345FlexibilityNo cancel feeOn-time71%
DeltaCheapest$203Average$356FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$387FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.