$180+ Cheap flights from Manchester, NH to Knoxville (MHT - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
MHT — TYS
Oct 11 — Oct 181
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Manchester to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Manchester to Knoxville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Manchester to KnoxvilleExplore the most affordable flight options available from Manchester to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
Explore the most affordable flight options available from Manchester to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:00 am -
1 stop4h 25m
Mon 11/26:10 pm -
1 stop5h 43m
Deal found 9/10![American Airlines logo]()
$303
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:12 pm -
1 stop4h 46m
Mon 11/1612:42 pm -
1 stop5h 32m
Deal found 9/10![American Airlines logo]()
$316
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:41 pm -
1 stop4h 18m
Tue 10/69:45 am -
1 stop4h 30m
Deal found 9/9![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/85:03 pm -
1 stop5h 45m
Sun 12/136:50 am -
1 stop7h 07m
Deal found 9/10![American Airlines logo]()
$345
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:41 pm -
1 stop4h 18m
Tue 10/69:45 am -
1 stop4h 30m
Deal found 9/10![United Airlines logo]()
$346
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:35 am -
1 stop10h 15m
Mon 1/48:10 am -
1 stop4h 05m
Deal found 9/9![Southwest logo]()
$360
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
1 stop4h 58m
Sat 11/72:13 pm -
1 stop7h 32m
Deal found 9/10![American Airlines logo]()
$383
Best flights from Manchester to KnoxvilleDiscover carefully curated flight deals from Manchester to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
Discover carefully curated flight deals from Manchester to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/178:50 am -
2 stops11h 40m
Mon 1/412:50 pm -
2 stops11h 00m
Deal found 9/9![Southwest logo]()
$421
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/289:25 am -
1 stop5h 23m
Sat 10/311:54 pm -
2 stops10h 05m
Deal found 9/8![United Airlines logo]()
$441
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:12 pm -
1 stop4h 46m
Mon 11/96:10 pm -
1 stop5h 43m
Deal found 9/8![American Airlines logo]()
$495
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:30 am -
2 stops11h 20m
Mon 11/912:50 pm -
2 stops11h 00m
Deal found 9/8![Southwest logo]()
$487
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:38 pm -
1 stop24h 10m
Mon 11/164:30 pm -
2 stops7h 29m
Deal found 9/10![United Airlines logo]()
$494
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:40 pm -
2 stops9h 00m
Wed 10/71:00 pm -
2 stops7h 35m
Deal found 9/9![Southwest logo]()
$547
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:25 am -
1 stop5h 23m
Sat 11/144:30 pm -
2 stops7h 29m
Deal found 9/9![United Airlines logo]()
$549
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:25 am -
2 stops7h 45m
Fri 10/167:25 pm -
2 stops13h 00m
Deal found 9/6![Southwest logo]()
$560
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/232:46 pm -
2 stops8h 03m
Sat 9/266:00 am -
2 stops13h 01m
Deal found 9/8![United Airlines logo]()
$597
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:40 am -
2 stops11h 30m
Fri 9/251:00 pm -
2 stops9h 30m
Deal found 9/6![Southwest logo]()
$589
Last-minute flights from Manchester to KnoxvilleDiscover last-minute flight deals from Manchester to Knoxville. Data last updated September 11, 2026 and is based on user searches.
Discover last-minute flight deals from Manchester to Knoxville. Data last updated September 11, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:41 pm -
1 stop4h 18m
Tue 10/69:45 am -
1 stop4h 30m
Deal found 9/9![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:03 pm -
1 stop4h 39m
Wed 10/711:35 am -
1 stop7h 30m
Deal found 9/8![American Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:04 pm -
1 stop4h 36m
Wed 10/76:05 pm -
1 stop5h 31m
Deal found 9/9![American Airlines logo]()
$316
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:41 pm -
1 stop4h 18m
Tue 10/69:45 am -
1 stop4h 30m
Deal found 9/10![United Airlines logo]()
$346
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:15 pm -
1 stop4h 40m
Mon 10/196:05 pm -
1 stop6h 18m
Deal found 9/7![American Airlines logo]()
$427
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:00 am -
1 stop4h 25m
Mon 11/26:10 pm -
1 stop5h 43m
Deal found 9/10![American Airlines logo]()
$303
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/289:25 am -
1 stop5h 23m
Sat 10/311:54 pm -
2 stops10h 05m
Deal found 9/8![United Airlines logo]()
$441
One-way flights from Manchester to KnoxvilleSearch for one-way flight options from Manchester to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
Search for one-way flight options from Manchester to Knoxville. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:25 am -
1 stop5h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$180
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:41 pm -
1 stop4h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![United Airlines logo]()
$192
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:00 am -
1 stop5h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![American Airlines logo]()
$194
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/309:25 am -
1 stop5h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![United Airlines logo]()
$205
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:41 pm -
1 stop4h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![United Airlines logo]()
$220
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:25 am -
2 stops11h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Southwest logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1412:18 pm -
3 stops45h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$246
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:05 pm -
1 stop4h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Southwest logo]()
$249
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/191:40 pm -
2 stops9h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Southwest logo]()
$269
Find flight deals from Manchester to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Manchester (MHT) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $303 (American Airlines) |
One-way from | $180 (United Airlines) |
Popular in | November |
Cheapest in | January |
Average price | $497 |
Cheapflights Fare Finder
Customize your flight search to find flights from Manchester to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
Use the filters below to find and compare flights from Manchester to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ManchesterKnoxville
MHT Manchester - TYS Knoxville McGhee Tyson
MHTTYS
Manchester
Sat 11/14
9:25 am-2:48 pm
1 stop5h 23m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$180
Quickest round-trip
ManchesterKnoxville
MHT Manchester - TYS Knoxville McGhee Tyson
MHTTYS
Manchester
Mon 10/19
7:41 pm-11:59 pm
1 stop4h 18m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$192
ManchesterKnoxville
MHT Manchester - TYS Knoxville McGhee Tyson
MHTTYS
Manchester
Wed 9/30
9:25 am-2:42 pm
1 stop5h 17m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$205
ManchesterKnoxville
MHT Manchester - TYS Knoxville McGhee Tyson
MHTTYS
Manchester
Wed 11/25
5:25 am-5:00 pm
2 stops11h 35m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$235
ManchesterKnoxville
MHT Manchester - TYS Knoxville McGhee Tyson
MHTTYS
Manchester
Sat 10/24
9:25 am-2:42 pm
1 stop5h 17m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$260
ManchesterKnoxville
MHT Manchester - TYS Knoxville McGhee Tyson
MHTTYS
Manchester
Fri 9/18
7:41 pm-11:59 pm
1 stop4h 18m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$325
ManchesterKnoxville
MHT Manchester - TYS Knoxville McGhee Tyson
MHTTYS
Manchester
Tue 9/15
9:25 am-2:37 pm
1 stop5h 12m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$399
ManchesterKnoxville
MHT Manchester - TYS Knoxville McGhee Tyson
MHTTYS
Manchester
Sun 10/11
8:30 am-7:05 pm
2 stops10h 35m
Knoxville McGhee Tyson
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$403
ManchesterKnoxville
MHT Manchester - TYS Knoxville McGhee Tyson
MHTTYS
Manchester
Thu 12/17
8:50 am-8:30 pm
2 stops11h 40m
Knoxville McGhee Tyson
Mon 1/4
12:50 pm-11:50 pm
2 stops11h 00m
$421
ManchesterKnoxville
MHT Manchester - TYS Knoxville McGhee Tyson
MHTTYS
Manchester
Wed 10/28
9:25 am-2:48 pm
1 stop5h 23m
Knoxville McGhee Tyson
Sat 10/31
1:54 pm-11:59 pm
2 stops10h 05m
$441
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Manchester to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Manchester to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Manchester, New Hampshire-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Manchester, New Hampshire-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Manchester, New Hampshire-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Manchester, New Hampshire-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Manchester, New Hampshire-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Manchester to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Manchester with our price prediction graph.
MHT-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Manchester to Knoxville
What is the cheapest month to book a flight from Manchester, New Hampshire to Knoxville?
Currently, January is the cheapest month in which you can book a flight from Manchester, New Hampshire to Knoxville (average of $422). Flying from Manchester, New Hampshire to Knoxville in November is currently the most expensive (average of $667). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Manchester, New Hampshire to Knoxville?
Airfare is below average for this route at the moment.
Manchester, New Hampshire to Knoxville flights typically cost between $394 and $518 in October.The cheapest round-trip price found within the last 5 days was $303 on American Airlines (Oct 28-Nov 2).
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAmerican Airlines from Manchester to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Manchester to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Other flights from Manchester
Popular flights
Alternative routes for Manchester to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Manchester to Knoxville by cabin class
Find flights from Manchester to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 11, 2026.
Manchester and Knoxville flights
Browse other Manchester and Knoxville flight options. Last updated on September 11, 2026.
Other flights from Manchester
Browse through other flights departing from Manchester. Flights are based on user searches made on Cheapflights and were last updated on September 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Manchester to Knoxville
Discover the top 3 airlines that operate flights from Manchester to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$279 | Average$497 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$325 | Average$460 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$335 | Average$492 | FlexibilityNo cancel fee | On-time71% |