$132+ Cheap flights from Knoxville to Manchester, NH (TYS - MHT)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MHT
Oct 15 — Oct 221
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Manchester with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Manchester
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Best
Last-minute
One-way
Cheapest flights from Knoxville to ManchesterExplore the most affordable flight options available from Knoxville to Manchester. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
Explore the most affordable flight options available from Knoxville to Manchester. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:05 pm -
1 stop6h 18m
Tue 10/206:00 am -
1 stop4h 33m
Deal found 9/15![American Airlines logo]()
$263
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/123:43 pm -
1 stop7h 11m
Mon 11/166:20 pm -
1 stop4h 28m
Deal found 9/15![American Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:05 pm -
1 stop5h 31m
Tue 10/206:00 am -
1 stop4h 25m
Deal found 9/11![American Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:50 pm -
2 stops11h 05m
Mon 11/162:10 pm -
1 stop6h 40m
Deal found 9/15![Southwest logo]()
$369
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
2 stops12h 50m
Tue 10/206:45 am -
2 stops9h 55m
Deal found 9/11![Southwest logo]()
$375
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:35 pm -
1 stop4h 24m
Sat 11/149:25 am -
1 stop5h 23m
Deal found 9/14![United Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:00 pm -
2 stops9h 45m
Tue 10/206:45 am -
2 stops9h 55m
Deal found 9/15![Southwest logo]()
$381
Best flights from Knoxville to ManchesterDiscover carefully curated flight deals from Knoxville to Manchester that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
Discover carefully curated flight deals from Knoxville to Manchester that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:50 pm -
2 stops11h 05m
Mon 11/162:10 pm -
1 stop6h 40m
Deal found 9/15![Southwest logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:35 pm -
1 stop4h 24m
Sat 11/149:25 am -
1 stop5h 23m
Deal found 9/14![United Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:15 am -
1 stop4h 29m
Wed 9/3010:33 am -
1 stop5h 02m
Deal found 9/12![American Airlines logo]()
$507
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:00 pm -
2 stops9h 45m
Tue 10/206:45 am -
2 stops9h 55m
Deal found 9/15![Southwest logo]()
$381
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
2 stops12h 50m
Tue 10/201:50 pm -
1 stop6h 20m
Deal found 9/11![Southwest logo]()
$394
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:45 pm -
2 stops9h 10m
Tue 10/66:45 am -
2 stops9h 55m
Deal found 9/13![Southwest logo]()
$508
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:40 pm -
2 stops11h 15m
Sat 11/285:20 am -
2 stops6h 55m
Deal found 9/10![Southwest logo]()
$509
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:45 pm -
2 stops9h 10m
Mon 10/56:20 am -
1 stop6h 50m
Deal found 9/13![Southwest logo]()
$527
Last-minute flights from Knoxville to ManchesterDiscover last-minute flight deals from Knoxville to Manchester. Data last updated September 15, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Manchester. Data last updated September 15, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:15 am -
1 stop4h 29m
Sat 9/264:44 pm -
1 stop4h 22m
Deal found 9/11![American Airlines logo]()
$507
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/299:45 am -
1 stop4h 30m
Mon 10/59:25 am -
1 stop5h 17m
Deal found 9/14![United Airlines logo]()
$495
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/304:46 pm -
1 stop6h 45m
Mon 10/57:15 pm -
1 stop4h 40m
Deal found 9/13![American Airlines logo]()
$477
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:45 pm -
2 stops9h 10m
Sat 10/33:30 pm -
1 stop4h 05m
Deal found 9/12![Southwest logo]()
$482
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:05 pm -
1 stop6h 18m
Tue 10/206:00 am -
1 stop4h 33m
Deal found 9/15![American Airlines logo]()
$263
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:00 pm -
2 stops9h 45m
Tue 10/206:45 am -
2 stops9h 55m
Deal found 9/15![Southwest logo]()
$381
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:05 pm -
1 stop5h 31m
Tue 10/206:00 am -
1 stop4h 25m
Deal found 9/11![American Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
2 stops12h 50m
Tue 10/206:45 am -
2 stops9h 55m
Deal found 9/11![Southwest logo]()
$375
One-way flights from Knoxville to ManchesterSearch for one-way flight options from Knoxville to Manchester. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
Search for one-way flight options from Knoxville to Manchester. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:17 am -
1 stop4h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![American Airlines logo]()
$132
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:35 pm -
1 stop4h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$244
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:42 am -
2 stops8h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![United Airlines logo]()
$250
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:25 pm -
1 stop4h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![United Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:20 am -
2 stops27h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Multiple Airlines logo]()
$288
Find flight deals from Knoxville to Manchester
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Manchester (MHT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $263 (American Airlines) |
One-way from | $132 (American Airlines) |
Popular in | April |
Cheapest in | February |
Average price | $376 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Manchester that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
Use the filters below to find and compare flights from Knoxville to Manchester that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleManchester
TYS Knoxville McGhee Tyson - MHT Manchester
TYSMHT
Knoxville McGhee Tyson
Tue 10/20
6:05 pm-12:23 am
1 stop6h 18m
Manchester
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$152
Quickest round-trip
KnoxvilleManchester
TYS Knoxville McGhee Tyson - MHT Manchester
TYSMHT
Knoxville McGhee Tyson
Thu 10/29
7:35 pm-11:59 pm
1 stop4h 24m
Manchester
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$244
KnoxvilleManchester
TYS Knoxville McGhee Tyson - MHT Manchester
TYSMHT
Knoxville McGhee Tyson
Tue 10/20
10:42 am-7:01 pm
2 stops8h 19m
Manchester
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$250
KnoxvilleManchester
TYS Knoxville McGhee Tyson - MHT Manchester
TYSMHT
Knoxville McGhee Tyson
Fri 10/9
7:25 pm-11:56 pm
1 stop4h 31m
Manchester
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$264
KnoxvilleManchester
TYS Knoxville McGhee Tyson - MHT Manchester
TYSMHT
Knoxville McGhee Tyson
Mon 9/21
1:00 pm-9:55 pm
1 stop8h 55m
Manchester
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$325
KnoxvilleManchester
TYS Knoxville McGhee Tyson - MHT Manchester
TYSMHT
Knoxville McGhee Tyson
Fri 9/25
1:00 pm-9:55 pm
1 stop8h 55m
Manchester
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$325
KnoxvilleManchester
TYS Knoxville McGhee Tyson - MHT Manchester
TYSMHT
Knoxville McGhee Tyson
Thu 11/12
12:50 pm-11:55 pm
2 stops11h 05m
Manchester
Mon 11/16
2:10 pm-8:50 pm
1 stop6h 40m
$369
KnoxvilleManchester
TYS Knoxville McGhee Tyson - MHT Manchester
TYSMHT
Knoxville McGhee Tyson
Fri 11/13
7:35 pm-11:59 pm
1 stop4h 24m
Manchester
Sat 11/14
9:25 am-2:48 pm
1 stop5h 23m
$379
KnoxvilleManchester
TYS Knoxville McGhee Tyson - MHT Manchester
TYSMHT
Knoxville McGhee Tyson
Tue 10/13
1:00 pm-10:45 pm
2 stops9h 45m
Manchester
Tue 10/20
6:45 am-4:40 pm
2 stops9h 55m
$381
KnoxvilleManchester
TYS Knoxville McGhee Tyson - MHT Manchester
TYSMHT
Knoxville McGhee Tyson
Thu 10/15
7:25 pm-8:15 am
2 stops12h 50m
Manchester
Tue 10/20
1:50 pm-8:10 pm
1 stop6h 20m
$394
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Manchester
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Manchester in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Manchester, New Hampshire flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Manchester, New Hampshire flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Manchester, New Hampshire flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Manchester, New Hampshire flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Manchester, New Hampshire flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Manchester
Have a flexible travel schedule? Discover the best time to fly to Manchester from Knoxville with our price prediction graph.
TYS-MHT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Manchester
Reviews of airlines servicing Manchester
Get insights into the airlines that provide service to Manchester. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Manchester. Reviews last updated September 15, 2026.
Read through reviews of airlines operating flights from Knoxville to Manchester, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Comfort
7.2
Food
6.4
Overall
7.1
Boarding
7.4
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Crew
7.9
Comfort
7.2
Food
6.4
Overall
7.1
Boarding
7.4
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Manchester. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Manchester?
Book flights to Manchester if you plan to visit one of these locationsKeene
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Other flights to Manchester
Explore flights to Manchester departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 15, 2026.
Knoxville and Manchester flights
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Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 15, 2026.
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Top airline flying from Knoxville to Manchester
Discover the top airline that operate flights from Knoxville to Manchester. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$310 | Average$401 | FlexibilityNo cancel fee | On-time71% |