$477+ Cheap flights from Santa Fe to Knoxville (SAF - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/20. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — TYS
Dec 9 — Dec 161
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Santa Fe to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santa Fe to Knoxville
Cheapest
Best
Last-minute
Cheapest flights from Santa Fe to KnoxvilleExplore the most affordable flight options available from Santa Fe to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 9, 2026.
Explore the most affordable flight options available from Santa Fe to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 9, 2026.
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:56 pm -
1 stop8h 51m
Tue 12/15:30 pm -
1 stop6h 27m
Deal found 11/9![American Airlines logo]()
$520
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:26 pm -
2 stops8h 33m
Tue 12/111:53 am -
2 stops26h 57m
Deal found 11/9![United Airlines logo]()
$822
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:05 am -
2 stops9h 30m
Sat 11/285:30 am -
1 stop6h 11m
Deal found 11/9![American Airlines logo]()
$830
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/243:20 pm -
1 stop5h 12m
Sat 11/285:03 pm -
1 stop5h 26m
Deal found 11/9![United Airlines logo]()
$865
Best flights from Santa Fe to KnoxvilleDiscover carefully curated flight deals from Santa Fe to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 9, 2026.
Discover carefully curated flight deals from Santa Fe to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 9, 2026.
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/207:00 am -
1 stop5h 55m
Sat 1/236:01 am -
1 stop7h 36m
Deal found 11/5![United Airlines logo]()
$477
Last-minute flights from Santa Fe to KnoxvilleDiscover last-minute flight deals from Santa Fe to Knoxville. Data last updated November 9, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Fe to Knoxville. Data last updated November 9, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:05 am -
2 stops9h 30m
Sat 11/285:30 am -
1 stop6h 11m
Deal found 11/9![American Airlines logo]()
$830
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/243:20 pm -
1 stop5h 12m
Sat 11/285:03 pm -
1 stop5h 26m
Deal found 11/9![United Airlines logo]()
$865
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:56 pm -
1 stop8h 51m
Tue 12/15:30 pm -
1 stop6h 27m
Deal found 11/9![American Airlines logo]()
$520
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:26 pm -
2 stops8h 33m
Tue 12/111:53 am -
2 stops26h 57m
Deal found 11/9![United Airlines logo]()
$822
Find flight deals from Santa Fe to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $477 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 9, 2026.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Santa FeKnoxville
SAF Santa Fe - TYS Knoxville McGhee Tyson
SAFTYS
Santa Fe
Wed 1/20
7:00 am-2:55 pm
1 stop5h 55m
Knoxville McGhee Tyson
Sat 1/23
6:01 am-11:37 am
1 stop7h 36m
$477
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Santa Fe-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Fe-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Fe-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Fe-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Fe-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Fe to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Fe with our price prediction graph.
SAF-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 9, 2026.
Read through reviews of airlines operating flights from Santa Fe to Knoxville, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Food
6.4
Boarding
7.4
Crew
7.9
Comfort
7.2
Overall
7.0
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Entertainment
6.8
Food
6.4
Boarding
7.4
Crew
7.9
Comfort
7.2
Overall
7.0
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Santa Fe to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Newport
Bryson City
Crossville
Morristown
Murphy
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Knoxville flight routes
Other flight options
Other flights from Santa Fe
Popular flights
Alternative routes for Santa Fe to Knoxville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Knoxville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Santa Fe to Knoxville by cabin class
Find flights from Santa Fe to Knoxville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 9, 2026.
Santa Fe and Knoxville flights
Browse other Santa Fe and Knoxville flight options. Last updated on November 9, 2026.
Other flights from Santa Fe
Browse through other flights departing from Santa Fe. Flights are based on user searches made on Cheapflights and were last updated on November 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Santa Fe to Knoxville
Discover the top airline that operate flights from Santa Fe to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$270 | Average$424 | FlexibilityNo cancel fee | On-time71% |