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$401+ Cheap flights from Santa Fe to Knoxville (SAF - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/11. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — TYS
Jun 21 — Jun 281
Sat 6/21
Sat 6/28
1 adult, Economy
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Cheap flight deals from Santa Fe to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 16, 2025.

Round-trip from

$401
(American Airlines)
From Santa Fe to Knoxville McGhee Tyson
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Find flight deals from Santa Fe to Knoxville

Cheapest flights from Santa Fe to Knoxville
Explore the most affordable flight options available from Santa Fe to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2025.

This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/116:15 amSAF - TYS
1 stop4h 57mAmerican Airlines
Wed 7/166:00 amTYS - SAF
1 stop5h 25mAmerican Airlines
Deal found 6/14$401
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/111:23 pmSAF - TYS
1 stop6h 59mUnited Airlines
Thu 7/174:35 pmTYS - SAF
1 stop7h 23mUnited Airlines
Deal found 6/14$528

Cheapflights Fare Finder

Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.

Fly from

Santa Fe

Fly to

Knoxville

Route

Depart

Return

Price

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Fri 7/11

6:15 am-1:12 pm

1 stop4h 57m

Knoxville McGhee Tyson

Wed 7/16

6:00 am-9:25 am

1 stop5h 25m

$401

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Fri 7/11

1:23 pm-10:22 pm

1 stop6h 59m

Knoxville McGhee Tyson

Thu 7/17

4:35 pm-9:58 pm

1 stop7h 23m

$528

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/14

Best time to book a flight from Santa Fe to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to Knoxville

What is the cheapest month to book a flight from Santa Fe to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Santa Fe to Knoxville (average of $296). Flying from Santa Fe to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 16, 2025.
United Airlines
7.4
Good
8,801 reviews

Crew

8.1

Comfort

7.3

Boarding

7.7

Entertainment

7.0

Overall

7.4

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
United Airlines
7.4
Good
8,801 reviews
United Airlines
7.4
Good
8,801 reviews

Crew

8.1

Comfort

7.3

Boarding

7.7

Entertainment

7.0

Overall

7.4

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,801 reviews

Crew

8.1

Comfort

7.3

Boarding

7.7

Entertainment

7.0

Overall

7.4

Food

6.6

Reviews

1 / 20
2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find deals for flights from Santa Fe to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Knoxville.

  • Can I find deals for business class flights from Santa Fe to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Fe to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santa Fe to Knoxville (average of $296). Flying from Santa Fe to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top airline flying from Santa Fe to Knoxville

Discover the top airline that operate flights from Santa Fe to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$298Average$453FlexibilityNo cancel feeOn-time71%

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