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$364+ Cheap flights from Santa Fe to Knoxville (SAF - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — TYS
Jul 24 — Jul 311
Fri 7/24
Fri 7/31
1 adult, Economy
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Cheap flight deals from Santa Fe to Knoxville

Cheapest flights from Santa Fe to Knoxville
Explore the most affordable flight options available from Santa Fe to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 24, 2026.

This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:35 am
SAF
-
TYS
1 stop7h 06m
American Airlines
Mon 7/135:37 am
TYS
-
SAF
1 stop6h 04m
American Airlines
Deal found 6/24$500
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:35 am
SAF
-
TYS
1 stop7h 06m
American Airlines
Sat 7/115:31 pm
TYS
-
SAF
1 stop6h 33m
American Airlines
Deal found 6/22$549
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3011:21 am
SAF
-
TYS
1 stop6h 09m
American Airlines
Mon 8/35:31 pm
TYS
-
SAF
1 stop6h 33m
American Airlines
Deal found 6/23$560
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:11 am
SAF
-
TYS
1 stop7h 17m
American Airlines
Mon 7/65:37 am
TYS
-
SAF
1 stop6h 04m
American Airlines
Deal found 6/24$611
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:35 am
SAF
-
TYS
1 stop7h 06m
American Airlines
Sun 8/25:31 pm
TYS
-
SAF
1 stop6h 33m
American Airlines
Deal found 6/20$670
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am
SAF
-
TYS
1 stop5h 36m
United Airlines
Tue 12/89:15 am
TYS
-
SAF
2 stops14h 46m
United Airlines
Deal found 6/23$671

Find flight deals from Santa Fe to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$500
(American Airlines)

One-way from

$364
(American Airlines)

Popular in

August

Cheapest in

December
Provider with most accurate pricing for Santa Fe-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Santa Fe-Knoxville McGhee Tyson flights.
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From Santa Fe to Knoxville McGhee Tyson
Search Deals
One-way flight from Santa Fe to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($18 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 24, 2026.
Use the filters below to find and compare flights from Santa Fe to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 7/7

7:35 am-4:41 pm

1 stop7h 06m

Knoxville McGhee Tyson

Sat 7/11

5:31 pm-10:04 pm

1 stop6h 33m

$549

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Wed 7/29

7:35 am-4:41 pm

1 stop7h 06m

Knoxville McGhee Tyson

Sun 8/2

5:31 pm-10:04 pm

1 stop6h 33m

$670

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Sat 12/5

1:20 pm-10:20 pm

1 stop7h 00m

Knoxville McGhee Tyson

Tue 12/8

7:00 am-10:01 pm

2 stops17h 01m

$671

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Fri 7/10

12:58 pm-11:51 pm

2 stops8h 53m

Knoxville McGhee Tyson

Mon 7/13

11:43 am-6:56 pm

2 stops9h 13m

$784
Cheapest one-way
Quickest one-way

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 10/20

1:58 pm-11:18 pm

1 stop7h 20m

$364

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Mon 10/19

7:25 pm-8:22 am

2 stops10h 57m

$374

Santa FeKnoxville

SAF - TYS

SAFTYS

Santa Fe

Tue 10/20

7:05 am-9:00 pm

3 stops11h 55m

$953

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/20

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Santa Fe-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Fe-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Fe-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Fe-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Fe-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Fe to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated June 24, 2026.
Read through reviews of airlines operating flights from Santa Fe to Knoxville, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,751 reviews

Overall

7.1

Food

6.4

Boarding

7.5

Crew

7.9

Entertainment

6.8

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!
American Airlines
7.1
Good
11,751 reviews
American Airlines
7.1
Good
11,751 reviews

Overall

7.1

Food

6.4

Boarding

7.5

Crew

7.9

Entertainment

6.8

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Fe to Knoxville?

    Airlines like American Airlines and United Airlines fly from Santa Fe to Knoxville in about 7h. The time it takes to get you to your destination can typically vary by up to 06m. The distance from Santa Fe to Knoxville is about 1236 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Santa Fe to Knoxville round-trip?

    Our cheapest airline available from Santa Fe to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $264 on this airline. Users have found that American Airlines is 41% cheaper than the other options available to this destination.

  • Can I find deals for flights from Santa Fe to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Knoxville.

  • Can I find deals for business class flights from Santa Fe to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Fe to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

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Top airline flying from Santa Fe to Knoxville

Discover the top airline that operate flights from Santa Fe to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$344FlexibilityNo cancel feeOn-time71%

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