$427+ Cheap flights from Knoxville to Santa Fe (TYS - SAF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/5. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAF
Oct 24 — Oct 311
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Santa Fe with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Santa Fe
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Best
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Cheapest flights from Knoxville to Santa FeExplore the most affordable flight options available from Knoxville to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
Explore the most affordable flight options available from Knoxville to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:32 pm -
1 stop6h 24m
Mon 11/96:05 am -
1 stop6h 00m
Deal found 9/22![American Airlines logo]()
$427
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:21 pm -
1 stop8h 16m
Mon 9/286:05 am -
1 stop5h 48m
Deal found 9/23![American Airlines logo]()
$549
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:26 pm -
1 stop6h 29m
Sun 10/253:11 pm -
1 stop6h 07m
Deal found 9/24![American Airlines logo]()
$584
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2610:42 am -
2 stops8h 29m
Mon 9/2810:00 am -
2 stops9h 55m
Deal found 9/23![United Airlines logo]()
$602
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:45 am -
2 stops8h 06m
Mon 11/91:26 pm -
1 stop7h 06m
Deal found 9/21![United Airlines logo]()
$603
Best flights from Knoxville to Santa FeDiscover carefully curated flight deals from Knoxville to Santa Fe that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
Discover carefully curated flight deals from Knoxville to Santa Fe that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/24:25 pm -
1 stop6h 26m
Sat 2/61:05 pm -
1 stop5h 54m
Deal found 9/23![United Airlines logo]()
$467
Last-minute flights from Knoxville to Santa FeDiscover last-minute flight deals from Knoxville to Santa Fe. Data last updated September 24, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santa Fe. Data last updated September 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:21 pm -
1 stop8h 16m
Mon 9/286:05 am -
1 stop5h 48m
Deal found 9/23![American Airlines logo]()
$549
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2610:42 am -
2 stops8h 29m
Mon 9/2810:00 am -
2 stops9h 55m
Deal found 9/23![United Airlines logo]()
$602
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
1 stop5h 43m
Wed 10/76:05 am -
1 stop6h 02m
Deal found 9/21![American Airlines logo]()
$697
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:26 pm -
1 stop6h 29m
Sat 10/106:05 am -
1 stop6h 02m
Deal found 9/21![American Airlines logo]()
$711
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop5h 42m
Fri 10/233:11 pm -
1 stop6h 07m
Deal found 9/23![American Airlines logo]()
$674
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:53 pm -
1 stop5h 35m
Fri 10/236:00 pm -
2 stops24h 19m
Deal found 9/23![United Airlines logo]()
$689
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:26 pm -
1 stop6h 29m
Sun 10/253:11 pm -
1 stop6h 07m
Deal found 9/24![American Airlines logo]()
$584
Find flight deals from Knoxville to Santa Fe
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $427 (American Airlines) |
Popular in | April |
Cheapest in | July |
Average price | $698 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Fe that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleSanta Fe
TYS Knoxville McGhee Tyson - SAF Santa Fe
TYSSAF
Knoxville McGhee Tyson
Tue 2/2
4:25 pm-8:51 pm
1 stop6h 26m
Santa Fe
Sat 2/6
1:05 pm-8:59 pm
1 stop5h 54m
$467
Sorted by cheapest first
Compare providers for flights from Knoxville to Santa Fe
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Fe in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Santa Fe flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Fe flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Fe flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santa Fe flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Fe flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santa Fe
Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Knoxville with our price prediction graph.
TYS-SAF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santa Fe
Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated September 24, 2026.
Read through reviews of airlines operating flights from Knoxville to Santa Fe, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Comfort
7.2
Entertainment
6.8
Boarding
7.4
Overall
7.0
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Crew
7.9
Food
6.4
Comfort
7.2
Entertainment
6.8
Boarding
7.4
Overall
7.0
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santa Fe?
Book flights to Santa Fe if you plan to visit one of these locationsSanta Rosa
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Top airline flying from Knoxville to Santa Fe
Discover the top airline that operate flights from Knoxville to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$315 | Average$590 | FlexibilityNo cancel fee | On-time71% |