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$324+ Cheap flights from Knoxville to Santa Fe (TYS - SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAF
Aug 10 — Aug 171
Mon 8/10
Mon 8/17
1 adult, Economy
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Cheap flight deals from Knoxville to Santa Fe

Cheapest flights from Knoxville to Santa Fe
Explore the most affordable flight options available from Knoxville to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 11, 2026.

This American Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:35 pm
TYS
-
SAF
1 stop6h 02m
American Airlines
Tue 9/226:05 am
SAF
-
TYS
1 stop5h 48m
American Airlines
Deal found 7/10$324
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:03 am
TYS
-
SAF
1 stop5h 48m
American Airlines
Sat 8/157:10 am
SAF
-
TYS
2 stops8h 24m
American Airlines
Deal found 7/8$369
This United Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/84:56 pm
TYS
-
SAF
1 stop5h 45m
United Airlines
Sat 8/153:22 pm
SAF
-
TYS
1 stop5h 07m
United Airlines
Deal found 7/8$416
This United Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/184:50 pm
TYS
-
SAF
1 stop5h 46m
United Airlines
Sat 8/227:10 am
SAF
-
TYS
1 stop6h 36m
United Airlines
Deal found 7/7$472
This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am
TYS
-
SAF
1 stop5h 42m
American Airlines
Fri 10/162:11 pm
SAF
-
TYS
1 stop7h 11m
American Airlines
Deal found 7/9$557
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:31 pm
TYS
-
SAF
1 stop6h 33m
American Airlines
Mon 7/277:35 am
SAF
-
TYS
1 stop7h 06m
American Airlines
Deal found 7/8$570

Find flight deals from Knoxville to Santa Fe

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$324
(American Airlines)
Provider with most accurate pricing for Knoxville McGhee Tyson-Santa Fe flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santa Fe flights.
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From Knoxville McGhee Tyson to Santa Fe
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 11, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Fe that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Wed 9/16

12:09 pm-9:37 pm

2 stops11h 28m

Santa Fe

Tue 9/22

6:05 am-1:53 pm

1 stop5h 48m

$392
Quickest round-trip

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sat 8/8

4:56 pm-8:41 pm

1 stop5h 45m

Santa Fe

Sat 8/15

3:22 pm-10:29 pm

1 stop5h 07m

$416

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Tue 8/18

7:00 am-5:11 pm

2 stops12h 11m

Santa Fe

Sat 8/22

1:22 pm-10:29 pm

1 stop7h 07m

$516

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sat 10/10

6:00 am-9:42 am

1 stop5h 42m

Santa Fe

Fri 10/16

2:11 pm-11:22 pm

1 stop7h 11m

$557

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Mon 8/24

7:00 am-5:11 pm

2 stops12h 11m

Santa Fe

Mon 8/31

3:21 pm-10:29 pm

1 stop5h 08m

$634

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Thu 7/23

12:10 pm-9:44 am

2 stops23h 34m

Santa Fe

Mon 7/27

1:22 pm-10:19 pm

1 stop6h 57m

$638

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Wed 12/9

7:35 pm-10:01 pm

2 stops28h 26m

Santa Fe

Sat 12/12

7:00 am-2:36 pm

1 stop5h 36m

$759
Cheapest one-way
Quickest one-way

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sun 11/1

7:30 am-12:59 pm

1 stop7h 29m

$623

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sun 11/1

5:45 am-12:48 pm

2 stops9h 03m

$1,175

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/8

Sorted by cheapest first

Compare providers for flights from Knoxville to Santa Fe

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Fe in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santa Fe flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Fe flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Fe flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santa Fe flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Fe flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santa Fe

Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated July 11, 2026.
Read through reviews of airlines operating flights from Knoxville to Santa Fe, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,806 reviews

Comfort

7.2

Entertainment

6.8

Food

6.4

Boarding

7.5

Crew

7.9

Overall

7.1

Reviews

1 / 20
8.0
Excellent

Olwin,Jul 2026

MCO - DCA

The flight was great overall. But we need better food on flights and the baggage fees are too high.
American Airlines
7.1
Good
11,806 reviews
American Airlines
7.1
Good
11,806 reviews

Comfort

7.2

Entertainment

6.8

Food

6.4

Boarding

7.5

Crew

7.9

Overall

7.1

Reviews

1 / 20
8.0
Excellent

Olwin,Jul 2026

MCO - DCA

The flight was great overall. But we need better food on flights and the baggage fees are too high.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santa Fe?

    Airlines like American Airlines and United Airlines fly from Knoxville to Santa Fe in about 5h 45m. The time it takes to get you to your destination can typically vary by up to 5h 43m. The distance from Knoxville to Santa Fe is about 1236 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Knoxville to Santa Fe round-trip?

    Our cheapest airline available from Knoxville to Santa Fe is American Airlines. Our recent data shows that you can find tickets from as low as $264 on this airline.

  • Can I find deals for flights from Knoxville to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Fe.

  • Can I find deals for business class flights from Knoxville to Santa Fe?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top airline flying from Knoxville to Santa Fe

Discover the top airline that operate flights from Knoxville to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$264Average$590FlexibilityNo cancel feeOn-time71%

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