$250+ Cheap flights from McAllen to Knoxville (MFE - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
MFE — TYS
May 23 — May 301
Round-trip
1 adult, Economy
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Find cheap flights from McAllen to Knoxville with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from McAllen to Knoxville
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Best
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Cheapest flights from McAllen to KnoxvilleExplore the most affordable flight options available from McAllen to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
Explore the most affordable flight options available from McAllen to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:43 am
MFE
- TYS
1 stop11h 32m
Allegiant Air
Sun 8/26:54 pm
TYS
- MFE
1 stop13h 59m
Allegiant Air
Deal found 4/19![Allegiant Air logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/2510:43 am
MFE
- TYS
1 stop10h 18m
Allegiant Air
Sun 8/26:54 pm
TYS
- MFE
1 stop13h 59m
Allegiant Air
Deal found 4/19![Allegiant Air logo]()
$343
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/287:00 am
MFE
- TYS
1 stop4h 51m
American Airlines
Wed 8/261:46 pm
TYS
- MFE
1 stop6h 30m
American Airlines
Deal found 4/22![American Airlines logo]()
$367
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:20 am
MFE
- TYS
2 stops8h 28m
Delta
Wed 8/267:07 am
TYS
- MFE
2 stops9h 52m
Delta
Deal found 4/22![Delta logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:43 am
MFE
- TYS
1 stop11h 32m
Multiple Airlines
Sun 8/23:38 pm
TYS
- MFE
2 stops17h 15m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$388
This United Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:38 am
MFE
- TYS
1 stop7h 27m
United Airlines
Wed 9/27:15 am
TYS
- MFE
1 stop5h 08m
United Airlines
Deal found 4/19![United Airlines logo]()
$401
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/205:44 am
MFE
- TYS
1 stop5h 46m
American Airlines
Sat 5/166:00 am
TYS
- MFE
1 stop5h 02m
American Airlines
Deal found 4/19![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:25 pm
MFE
- TYS
1 stop5h 31m
American Airlines
Wed 6/35:33 pm
TYS
- MFE
1 stop7h 48m
American Airlines
Deal found 4/21![American Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/2510:43 am
MFE
- TYS
1 stop10h 18m
Multiple Airlines
Sun 8/23:38 pm
TYS
- MFE
2 stops17h 15m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$426
Best flights from McAllen to KnoxvilleDiscover carefully curated flight deals from McAllen to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
Discover carefully curated flight deals from McAllen to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/287:00 am
MFE
- TYS
1 stop4h 51m
American Airlines
Wed 8/261:46 pm
TYS
- MFE
1 stop6h 30m
American Airlines
Deal found 4/22![American Airlines logo]()
$367
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:20 am
MFE
- TYS
2 stops8h 28m
Delta
Wed 8/267:07 am
TYS
- MFE
2 stops9h 52m
Delta
Deal found 4/22![Delta logo]()
$375
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2912:07 pm
MFE
- TYS
1 stop4h 58m
United Airlines
Wed 9/26:30 am
TYS
- MFE
2 stops10h 29m
United Airlines
Deal found 4/18![United Airlines logo]()
$406
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/2510:43 am
MFE
- TYS
1 stop10h 18m
Multiple Airlines
Mon 8/37:20 pm
TYS
- MFE
2 stops45h 44m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$474
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2412:35 pm
MFE
- TYS
2 stops10h 17m
Delta
Sun 8/25:40 am
TYS
- MFE
2 stops7h 15m
Delta
Deal found 4/19![Delta logo]()
$489
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/35:44 am
MFE
- TYS
2 stops8h 54m
American Airlines
Tue 5/56:00 am
TYS
- MFE
1 stop5h 02m
American Airlines
Deal found 4/19![American Airlines logo]()
$542
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3012:56 pm
MFE
- TYS
2 stops10h 05m
Delta
Wed 6/35:40 am
TYS
- MFE
2 stops11h 57m
Delta
Deal found 4/21![Delta logo]()
$532
Last-minute flights from McAllen to KnoxvilleDiscover last-minute flight deals from McAllen to Knoxville. Data last updated April 23, 2026 and is based on user searches.
Discover last-minute flight deals from McAllen to Knoxville. Data last updated April 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:00 pm
MFE
- TYS
1 stop20h 49m
Allegiant Air
Sun 5/38:20 am
TYS
- MFE
1 stop10h 20m
Allegiant Air
Deal found 4/22![Allegiant Air logo]()
$625
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:00 am
MFE
- TYS
1 stop5h 34m
United Airlines
Sun 5/33:30 pm
TYS
- MFE
1 stop7h 18m
United Airlines
Deal found 4/22![United Airlines logo]()
$569
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:40 am
MFE
- TYS
1 stop7h 38m
American Airlines
Tue 5/51:20 pm
TYS
- MFE
1 stop5h 10m
American Airlines
Deal found 4/19![American Airlines logo]()
$537
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/37:00 am
MFE
- TYS
1 stop5h 34m
United Airlines
Tue 5/53:30 pm
TYS
- MFE
1 stop5h 24m
United Airlines
Deal found 4/22![United Airlines logo]()
$675
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:25 pm
MFE
- TYS
1 stop5h 31m
American Airlines
Wed 6/35:33 pm
TYS
- MFE
1 stop7h 48m
American Airlines
Deal found 4/21![American Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:36 pm
MFE
- TYS
1 stop28h 30m
Multiple Airlines
Wed 6/38:32 pm
TYS
- MFE
2 stops40h 01m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$481
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3012:56 pm
MFE
- TYS
2 stops10h 05m
Delta
Wed 6/35:40 am
TYS
- MFE
2 stops11h 57m
Delta
Deal found 4/21![Delta logo]()
$532
One-way flights from McAllen to KnoxvilleSearch for one-way flight options from McAllen to Knoxville. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
Search for one-way flight options from McAllen to Knoxville. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:15 pm
MFE
- TYS
3 stops20h 26m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$250
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/43:45 pm
MFE
- TYS
1 stop7h 11m
American Airlines
Deal found 4/19![American Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/412:15 pm
MFE
- TYS
3 stops45h 21m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$320
Find flight deals from McAllen to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from McAllen (MFE) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $300 (Kiwi.com) |
One-way from | $250 (Kiwi.com) |
Popular in | January |
Cheapest in | May |
Average price | $433 |
Cheapflights Fare Finder
Customize your flight search to find flights from McAllen to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from McAllen to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Tue 7/28
7:00 am-12:51 pm
1 stop4h 51m
Knoxville McGhee Tyson
Wed 8/26
1:46 pm-7:16 pm
1 stop6h 30m
$367
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Tue 7/28
5:20 am-2:48 pm
2 stops8h 28m
Knoxville McGhee Tyson
Wed 8/26
7:07 am-3:59 pm
2 stops9h 52m
$375
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Sat 8/29
12:07 pm-6:05 pm
1 stop4h 58m
Knoxville McGhee Tyson
Wed 9/2
6:30 am-3:59 pm
2 stops10h 29m
$406
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Sat 7/25
10:43 am-10:01 pm
1 stop10h 18m
Knoxville McGhee Tyson
Mon 8/3
7:20 pm-4:04 pm
2 stops45h 44m
$474
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Fri 7/24
12:35 pm-11:52 pm
2 stops10h 17m
Knoxville McGhee Tyson
Sun 8/2
5:40 am-11:55 am
2 stops7h 15m
$489
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Sat 5/30
12:56 pm-12:01 am
2 stops10h 05m
Knoxville McGhee Tyson
Wed 6/3
5:40 am-4:37 pm
2 stops11h 57m
$532
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Sun 5/3
5:44 am-3:38 pm
2 stops8h 54m
Knoxville McGhee Tyson
Tue 5/5
6:00 am-10:02 am
1 stop5h 02m
$542
Cheapest one-way
Quickest one-way
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Wed 5/6
6:40 am-3:19 pm
1 stop7h 39m
$269
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Mon 5/4
1:10 pm-10:24 pm
2 stops8h 14m
$274
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Mon 5/4
12:15 pm-10:36 am
3 stops45h 21m
$320
Sorted by cheapest first
Compare providers for flights from McAllen to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from McAllen to Knoxville in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on McAllen-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on McAllen-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from McAllen-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on McAllen-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for McAllen-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from McAllen to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from McAllen with our price prediction graph.
MFE-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from McAllen to Knoxville
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 23, 2026.
Get a feel of what it's like to fly with American Airlines from McAllen to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.2
Boarding
7.5
Crew
7.9
Food
6.4
Overall
7.1
Entertainment
6.9
Reviews
1 / 20
6.0
Goodsheila,Mar 2025
DFW - MSP
Comfort
7.2
Boarding
7.5
Crew
7.9
Food
6.4
Overall
7.1
Entertainment
6.9
Reviews
1 / 20
6.0
Goodsheila,Mar 2025
DFW - MSP
Related info for your journey
Find useful and relevant information for your journey from McAllen to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Alcoa
Murphy
Oak Ridge
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Other flights to Knoxville
Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 23, 2026.
McAllen and Knoxville flights
Browse other McAllen and Knoxville flight options. Last updated on April 23, 2026.
Other flights from McAllen
Browse through other flights departing from McAllen. Flights are based on user searches made on Cheapflights and were last updated on April 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from McAllen to Knoxville
Discover the top airline that operate flights from McAllen to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$355 | Average$449 | FlexibilityNo cancel fee | On-time71% |