$459+ Cheap flights from McAllen to Knoxville (MFE - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/30. Fares are subject to change and may not be available on all flights or dates of travel.
MFE — TYS
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from McAllen to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from McAllen to Knoxville
Cheapest
Best
Last-minute
Cheapest flights from McAllen to KnoxvilleExplore the most affordable flight options available from McAllen to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from McAllen to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:19 pm -
1 stop6h 13m
Sat 11/285:30 am -
1 stop6h 37m
Deal found 10/24![American Airlines logo]()
$574
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:00 am -
1 stop15h 57m
Tue 11/103:45 pm -
1 stop7h 13m
Deal found 10/22![United Airlines logo]()
$768
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/254:19 pm -
1 stop6h 13m
Mon 11/305:30 am -
1 stop6h 37m
Deal found 10/21![American Airlines logo]()
$798
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/254:19 pm -
1 stop6h 13m
Sun 11/295:30 am -
1 stop6h 37m
Deal found 10/23![American Airlines logo]()
$1,004
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:59 pm -
2 stops8h 13m
Mon 11/305:40 am -
2 stops10h 54m
Deal found 10/22![Delta logo]()
$1,009
Best flights from McAllen to KnoxvilleDiscover carefully curated flight deals from McAllen to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from McAllen to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/302:12 pm -
1 stop6h 47m
Wed 2/311:53 am -
1 stop5h 13m
Deal found 10/24![United Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/254:19 pm -
1 stop6h 13m
Mon 11/305:30 am -
1 stop6h 37m
Deal found 10/21![American Airlines logo]()
$798
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:00 am -
1 stop15h 57m
Tue 11/103:45 pm -
1 stop7h 13m
Deal found 10/22![United Airlines logo]()
$768
Last-minute flights from McAllen to KnoxvilleDiscover last-minute flight deals from McAllen to Knoxville. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from McAllen to Knoxville. Data last updated October 25, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:00 am -
1 stop15h 57m
Tue 11/103:45 pm -
1 stop7h 13m
Deal found 10/22![United Airlines logo]()
$768
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:19 pm -
1 stop6h 13m
Sat 11/285:30 am -
1 stop6h 37m
Deal found 10/24![American Airlines logo]()
$574
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/254:19 pm -
1 stop6h 13m
Mon 11/305:30 am -
1 stop6h 37m
Deal found 10/21![American Airlines logo]()
$798
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/254:19 pm -
1 stop6h 13m
Sun 11/295:30 am -
1 stop6h 37m
Deal found 10/23![American Airlines logo]()
$1,004
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:59 pm -
2 stops8h 13m
Mon 11/305:40 am -
2 stops10h 54m
Deal found 10/22![Delta logo]()
$1,009
Find flight deals from McAllen to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from McAllen (MFE) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $459 (United Airlines) |
Popular in | January |
Cheapest in | October |
Average price | $418 |
Cheapflights Fare Finder
Customize your flight search to find flights from McAllen to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from McAllen to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
McAllenKnoxville
MFE McAllen Miller Intl - TYS Knoxville McGhee Tyson
MFETYS
McAllen Miller Intl
Sat 1/30
2:12 pm-9:59 pm
1 stop6h 47m
Knoxville McGhee Tyson
Wed 2/3
11:53 am-4:06 pm
1 stop5h 13m
$459
McAllenKnoxville
MFE McAllen Miller Intl - TYS Knoxville McGhee Tyson
MFETYS
McAllen Miller Intl
Fri 11/6
5:00 am-9:57 pm
1 stop15h 57m
Knoxville McGhee Tyson
Tue 11/10
3:45 pm-9:58 pm
1 stop7h 13m
$768
McAllenKnoxville
MFE McAllen Miller Intl - TYS Knoxville McGhee Tyson
MFETYS
McAllen Miller Intl
Wed 11/25
4:19 pm-11:32 pm
1 stop6h 13m
Knoxville McGhee Tyson
Mon 11/30
5:30 am-11:07 am
1 stop6h 37m
$798
Sorted by cheapest first
Compare providers for flights from McAllen to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from McAllen to Knoxville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on McAllen-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on McAllen-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from McAllen-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on McAllen-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for McAllen-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from McAllen to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from McAllen with our price prediction graph.
MFE-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated October 25, 2026.
Get a feel of what it's like to fly with American Airlines from McAllen to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Boarding
7.4
Comfort
7.1
Overall
7.0
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Crew
7.9
Food
6.4
Boarding
7.4
Comfort
7.1
Overall
7.0
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Related info for your journey
Find useful and relevant information for your journey from McAllen to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
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Top airline flying from McAllen to Knoxville
Discover the top airline that operate flights from McAllen to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$324 | Average$481 | FlexibilityNo cancel fee | On-time71% |