$321+ Cheap flights from McAllen to Knoxville (MFE - TYS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel.
MFE — TYS
Oct 9 — Oct 161
Round-trip
1 adult, Economy
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Find cheap flights from McAllen to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from McAllen to Knoxville
Cheapest
Best
Last-minute
Cheapest flights from McAllen to KnoxvilleExplore the most affordable flight options available from McAllen to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from McAllen to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:37 pm -
1 stop5h 41m
Tue 10/276:00 am -
1 stop5h 32m
Deal found 9/8![American Airlines logo]()
$321
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:35 pm -
1 stop5h 47m
Wed 10/78:02 pm -
1 stop5h 00m
Deal found 9/8![American Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:39 pm -
2 stops8h 48m
Wed 10/74:11 pm -
2 stops8h 48m
Deal found 9/8![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:11 pm -
1 stop6h 44m
Tue 10/276:45 am -
2 stops10h 19m
Deal found 9/8![United Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:46 pm -
2 stops6h 22m
Tue 10/275:40 am -
2 stops10h 42m
Deal found 9/8![Delta logo]()
$407
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:37 pm -
1 stop5h 41m
Fri 10/306:00 am -
1 stop5h 32m
Deal found 9/8![American Airlines logo]()
$466
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:02 pm -
2 stops6h 57m
Fri 10/305:40 am -
2 stops7h 26m
Deal found 9/8![Delta logo]()
$469
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:18 pm -
2 stops37h 53m
Fri 10/3012:49 pm -
1 stop9h 39m
Deal found 9/8![Multiple Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:35 pm -
1 stop5h 47m
Mon 9/145:35 pm -
1 stop5h 09m
Deal found 9/6![American Airlines logo]()
$545
Best flights from McAllen to KnoxvilleDiscover carefully curated flight deals from McAllen to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from McAllen to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:37 pm -
1 stop5h 41m
Tue 10/276:00 am -
1 stop5h 32m
Deal found 9/8![American Airlines logo]()
$321
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:11 pm -
1 stop6h 44m
Tue 10/276:45 am -
2 stops10h 19m
Deal found 9/8![United Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:02 pm -
2 stops6h 57m
Fri 10/305:40 am -
2 stops7h 26m
Deal found 9/8![Delta logo]()
$469
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/252:08 pm -
1 stop6h 39m
Mon 11/305:30 pm -
1 stop7h 48m
Deal found 9/5![American Airlines logo]()
$845
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:20 am -
2 stops7h 35m
Sat 11/285:40 am -
2 stops10h 54m
Deal found 9/7![Delta logo]()
$939
Last-minute flights from McAllen to KnoxvilleDiscover last-minute flight deals from McAllen to Knoxville. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from McAllen to Knoxville. Data last updated September 9, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:35 pm -
1 stop5h 47m
Mon 9/145:35 pm -
1 stop5h 09m
Deal found 9/6![American Airlines logo]()
$545
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:35 pm -
1 stop5h 47m
Wed 10/78:02 pm -
1 stop5h 00m
Deal found 9/8![American Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:39 pm -
2 stops8h 48m
Wed 10/74:11 pm -
2 stops8h 48m
Deal found 9/8![Delta logo]()
$359
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:37 pm -
1 stop5h 41m
Fri 10/306:00 am -
1 stop5h 32m
Deal found 9/8![American Airlines logo]()
$466
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:02 pm -
2 stops6h 57m
Fri 10/305:40 am -
2 stops7h 26m
Deal found 9/8![Delta logo]()
$469
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:18 pm -
2 stops37h 53m
Fri 10/3012:49 pm -
1 stop9h 39m
Deal found 9/8![Multiple Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:37 pm -
1 stop5h 41m
Tue 10/276:00 am -
1 stop5h 32m
Deal found 9/8![American Airlines logo]()
$321
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:11 pm -
1 stop6h 44m
Tue 10/276:45 am -
2 stops10h 19m
Deal found 9/8![United Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:46 pm -
2 stops6h 22m
Tue 10/275:40 am -
2 stops10h 42m
Deal found 9/8![Delta logo]()
$407
Find flight deals from McAllen to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from McAllen (MFE) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $321 (American Airlines) |
Popular in | January |
Cheapest in | October |
Cheapflights Fare Finder
Customize your flight search to find flights from McAllen to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from McAllen to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
McAllenKnoxville
MFE McAllen Miller Intl - TYS Knoxville McGhee Tyson
MFETYS
McAllen Miller Intl
Sat 10/24
4:37 pm-11:18 pm
1 stop5h 41m
Knoxville McGhee Tyson
Tue 10/27
6:00 am-10:32 am
1 stop5h 32m
$321
McAllenKnoxville
MFE McAllen Miller Intl - TYS Knoxville McGhee Tyson
MFETYS
McAllen Miller Intl
Sat 10/24
2:11 pm-9:55 pm
1 stop6h 44m
Knoxville McGhee Tyson
Tue 10/27
6:45 am-4:04 pm
2 stops10h 19m
$378
McAllenKnoxville
MFE McAllen Miller Intl - TYS Knoxville McGhee Tyson
MFETYS
McAllen Miller Intl
Fri 10/23
4:02 pm-11:59 pm
2 stops6h 57m
Knoxville McGhee Tyson
Fri 10/30
5:40 am-12:06 pm
2 stops7h 26m
$469
McAllenKnoxville
MFE McAllen Miller Intl - TYS Knoxville McGhee Tyson
MFETYS
McAllen Miller Intl
Wed 11/25
2:08 pm-9:47 pm
1 stop6h 39m
Knoxville McGhee Tyson
Mon 11/30
5:30 pm-12:18 am
1 stop7h 48m
$845
McAllenKnoxville
MFE McAllen Miller Intl - TYS Knoxville McGhee Tyson
MFETYS
McAllen Miller Intl
Wed 11/25
5:20 am-1:55 pm
2 stops7h 35m
Knoxville McGhee Tyson
Sat 11/28
5:40 am-3:34 pm
2 stops10h 54m
$939
Sorted by cheapest first
Compare providers for flights from McAllen to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from McAllen to Knoxville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on McAllen-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on McAllen-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from McAllen-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on McAllen-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for McAllen-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from McAllen to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from McAllen with our price prediction graph.
MFE-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 9, 2026.
Get a feel of what it's like to fly with American Airlines from McAllen to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.1
Food
6.4
Crew
7.9
Comfort
7.2
Entertainment
6.8
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Overall
7.1
Food
6.4
Crew
7.9
Comfort
7.2
Entertainment
6.8
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Related info for your journey
Find useful and relevant information for your journey from McAllen to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
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Top airline flying from McAllen to Knoxville
Discover the top airline that operate flights from McAllen to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$324 | Average$531 | FlexibilityNo cancel fee | On-time71% |