$387+ Cheap flights from Knoxville to McAllen (TYS - MFE)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MFE
Oct 14 — Oct 211
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to McAllen with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to McAllen
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to McAllenExplore the most affordable flight options available from Knoxville to McAllen. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2026.
Explore the most affordable flight options available from Knoxville to McAllen. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:15 am -
1 stop7h 12m
Mon 9/215:19 am -
1 stop6h 31m
Deal found 9/9![United Airlines logo]()
$451
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1912:09 pm -
2 stops8h 08m
Mon 9/214:35 pm -
1 stop5h 47m
Deal found 9/9![American Airlines logo]()
$456
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:40 am -
2 stops7h 19m
Mon 9/215:20 am -
2 stops11h 18m
Deal found 9/9![Delta logo]()
$462
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:00 am -
1 stop7h 29m
Mon 11/97:00 am -
2 stops12h 54m
Deal found 9/9![United Airlines logo]()
$525
Best flights from Knoxville to McAllenDiscover carefully curated flight deals from Knoxville to McAllen that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 14, 2026.
Discover carefully curated flight deals from Knoxville to McAllen that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 14, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:15 am -
1 stop7h 12m
Mon 9/215:19 am -
1 stop6h 31m
Deal found 9/9![United Airlines logo]()
$451
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:00 am -
1 stop7h 29m
Mon 11/97:00 am -
2 stops12h 54m
Deal found 9/9![United Airlines logo]()
$525
Last-minute flights from Knoxville to McAllenDiscover last-minute flight deals from Knoxville to McAllen. Data last updated September 14, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to McAllen. Data last updated September 14, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:15 pm -
1 stop4h 44m
Fri 9/182:08 pm -
1 stop27h 07m
Deal found 9/10![United Airlines logo]()
$750
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:49 pm -
1 stop25h 10m
Thu 9/241:19 pm -
1 stop25h 39m
Deal found 9/9![Allegiant Air logo]()
$710
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:15 am -
1 stop7h 12m
Mon 9/215:19 am -
1 stop6h 31m
Deal found 9/9![United Airlines logo]()
$451
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1912:09 pm -
2 stops8h 08m
Mon 9/214:35 pm -
1 stop5h 47m
Deal found 9/9![American Airlines logo]()
$456
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:40 am -
2 stops7h 19m
Mon 9/215:20 am -
2 stops11h 18m
Deal found 9/9![Delta logo]()
$462
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1910:45 am -
2 stops12h 14m
Fri 9/257:00 am -
1 stop27h 17m
Deal found 9/9![United Airlines logo]()
$655
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:15 am -
1 stop7h 12m
Thu 9/247:00 am -
2 stops12h 49m
Deal found 9/9![United Airlines logo]()
$718
One-way flights from Knoxville to McAllenSearch for one-way flight options from Knoxville to McAllen. Find affordable one-way fares based on user searches. Data last updated September 14, 2026.
Search for one-way flight options from Knoxville to McAllen. Find affordable one-way fares based on user searches. Data last updated September 14, 2026.
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:35 pm -
1 stop5h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![American Airlines logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:55 pm -
3 stops50h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$591
Find flight deals from Knoxville to McAllen
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to McAllen (MFE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $525 (United Airlines) |
One-way from | $387 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to McAllen that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 14, 2026.
Use the filters below to find and compare flights from Knoxville to McAllen that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleMcAllen
TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl
TYSMFE
Knoxville McGhee Tyson
Sat 9/19
5:35 pm-9:44 pm
1 stop5h 09m
McAllen Miller Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$387
KnoxvilleMcAllen
TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl
TYSMFE
Knoxville McGhee Tyson
Sat 9/19
7:15 am-1:27 pm
1 stop7h 12m
McAllen Miller Intl
Mon 9/21
5:19 am-12:50 pm
1 stop6h 31m
$451
KnoxvilleMcAllen
TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl
TYSMFE
Knoxville McGhee Tyson
Thu 11/5
7:00 am-1:29 pm
1 stop7h 29m
McAllen Miller Intl
Mon 11/9
7:00 am-8:54 pm
2 stops12h 54m
$525
KnoxvilleMcAllen
TYS Knoxville McGhee Tyson - MFE McAllen Miller Intl
TYSMFE
Knoxville McGhee Tyson
Sat 9/19
6:55 pm-8:33 pm
3 stops50h 38m
McAllen Miller Intl
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$591
Sorted by cheapest first
Compare providers for flights from Knoxville to McAllen
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to McAllen in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-McAllen flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-McAllen flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-McAllen flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-McAllen flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-McAllen flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to McAllen
Have a flexible travel schedule? Discover the best time to fly to McAllen from Knoxville with our price prediction graph.
TYS-MFE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing McAllen
Get insights into the airlines that provide service to McAllen. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to McAllen. Reviews last updated September 14, 2026.
Get a feel of what it's like to fly with American Airlines from Knoxville to McAllen by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Overall
7.1
Boarding
7.4
Comfort
7.2
Food
6.4
Crew
7.9
Reviews
1 / 20
8.0
ExcellentMonica,Nov 2025
JAC - DFW
Entertainment
6.8
Overall
7.1
Boarding
7.4
Comfort
7.2
Food
6.4
Crew
7.9
Reviews
1 / 20
8.0
ExcellentMonica,Nov 2025
JAC - DFW
Related info for your journey
Find useful and relevant information for your journey from Knoxville to McAllen. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near McAllen?
Book flights to McAllen if you plan to visit one of these locationsPharr
Weslaco
Mission
Edinburg
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Explore flights to McAllen departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 14, 2026.
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Top airline flying from Knoxville to McAllen
Discover the top airline that operate flights from Knoxville to McAllen. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$278 | Average$485 | FlexibilityNo cancel fee | On-time71% |