$129+ Cheap flights from Knoxville to San Antonio (TYS - SAT)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAT
Jun 10 — Jun 171
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to San AntonioExplore the most affordable flight options available from Knoxville to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.
Explore the most affordable flight options available from Knoxville to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.
This Frontier deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- SAT
1 stop23h 27m
Frontier
Tue 6/97:51 pm
SAT
- TYS
1 stop22h 46m
Frontier
Deal found 5/11![Frontier logo]()
$206
This Mytrip deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- SAT
1 stop23h 27m
Frontier
Sun 6/77:54 pm
SAT
- TYS
1 stop22h 39m
Frontier
Deal found 5/7![Frontier logo]()
$233
This Booking.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:32 pm
TYS
- SAT
1 stop23h 27m
Frontier
Sun 6/77:54 pm
SAT
- TYS
1 stop22h 39m
Frontier
Deal found 5/9![Frontier logo]()
$242
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:00 am
TYS
- SAT
1 stop5h 09m
American Airlines
Wed 9/165:00 am
SAT
- TYS
1 stop7h 06m
American Airlines
Deal found 5/6![American Airlines logo]()
$257
This Mytrip deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/228:32 pm
TYS
- SAT
1 stop23h 24m
Frontier
Thu 6/257:51 pm
SAT
- TYS
1 stop22h 46m
Frontier
Deal found 5/7![Frontier logo]()
$260
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:07 pm
TYS
- SAT
1 stop5h 10m
American Airlines
Tue 6/25:52 pm
SAT
- TYS
1 stop4h 55m
American Airlines
Deal found 5/7![American Airlines logo]()
$267
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:15 am
TYS
- SAT
1 stop6h 17m
American Airlines
Mon 8/247:00 am
SAT
- TYS
1 stop4h 56m
American Airlines
Deal found 5/6![American Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:33 pm
TYS
- SAT
1 stop6h 33m
American Airlines
Sat 6/65:35 pm
SAT
- TYS
1 stop5h 20m
American Airlines
Deal found 5/8![American Airlines logo]()
$284
This Southwest deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:35 pm
TYS
- SAT
1 stop4h 05m
Southwest
Wed 9/1611:30 am
SAT
- TYS
2 stops7h 20m
Southwest
Deal found 5/6![Southwest logo]()
$285
This Gotogate deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:19 pm
TYS
- SAT
1 stop23h 40m
Frontier
Sun 5/247:54 pm
SAT
- TYS
1 stop22h 30m
Frontier
Deal found 5/9![Frontier logo]()
$290
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/267:46 pm
TYS
- SAT
1 stop5h 47m
Delta
Tue 6/305:25 am
SAT
- TYS
1 stop4h 44m
Delta
Deal found 5/10![Delta logo]()
$293
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:40 am
TYS
- SAT
1 stop5h 12m
Delta
Wed 6/245:25 am
SAT
- TYS
1 stop4h 44m
Delta
Deal found 5/10![Delta logo]()
$295
Best flights from Knoxville to San AntonioDiscover carefully curated flight deals from Knoxville to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 11, 2026.
Discover carefully curated flight deals from Knoxville to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 11, 2026.
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/291:59 pm
TYS
- SAT
1 stop7h 29m
Delta
Tue 6/25:00 pm
SAT
- TYS
1 stop6h 01m
Delta
Deal found 5/10![Delta logo]()
$267
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:45 pm
TYS
- SAT
1 stop6h 30m
Southwest
Tue 6/95:30 am
SAT
- TYS
2 stops10h 30m
Southwest
Deal found 5/11![Southwest logo]()
$320
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:33 pm
TYS
- SAT
1 stop6h 11m
Delta
Sat 6/65:00 pm
SAT
- TYS
1 stop6h 01m
Delta
Deal found 5/10![Delta logo]()
$300
This Southwest deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:45 pm
TYS
- SAT
1 stop6h 15m
Southwest
Wed 6/175:45 am
SAT
- TYS
1 stop11h 35m
Southwest
Deal found 5/6![Southwest logo]()
$326
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:08 pm
TYS
- SAT
1 stop7h 25m
Delta
Sun 7/56:19 pm
SAT
- TYS
1 stop4h 35m
Delta
Deal found 5/10![Delta logo]()
$326
This Southwest deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/72:05 pm
TYS
- SAT
1 stop5h 55m
Southwest
Mon 8/107:00 am
SAT
- TYS
1 stop3h 55m
Southwest
Deal found 5/6![Southwest logo]()
$329
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:50 pm
TYS
- SAT
1 stop9h 15m
Southwest
Tue 6/27:00 am
SAT
- TYS
2 stops9h 10m
Southwest
Deal found 5/7![Southwest logo]()
$339
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:50 pm
TYS
- SAT
2 stops8h 25m
Southwest
Wed 6/35:55 am
SAT
- TYS
1 stop10h 15m
Southwest
Deal found 5/8![Southwest logo]()
$349
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/312:50 pm
TYS
- SAT
2 stops8h 25m
Southwest
Sat 6/611:40 am
SAT
- TYS
1 stop5h 40m
Southwest
Deal found 5/7![Southwest logo]()
$377
Last-minute flights from Knoxville to San AntonioDiscover last-minute flight deals from Knoxville to San Antonio. Data last updated May 11, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Antonio. Data last updated May 11, 2026 and is based on user searches.
This Gotogate deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:19 pm
TYS
- SAT
1 stop23h 40m
Frontier
Sun 5/247:54 pm
SAT
- TYS
1 stop22h 30m
Frontier
Deal found 5/9![Frontier logo]()
$290
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:07 pm
TYS
- SAT
1 stop5h 10m
American Airlines
Tue 6/25:52 pm
SAT
- TYS
1 stop4h 55m
American Airlines
Deal found 5/7![American Airlines logo]()
$267
This Southwest deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:50 pm
TYS
- SAT
1 stop9h 15m
Southwest
Fri 6/511:45 am
SAT
- TYS
2 stops8h 25m
Southwest
Deal found 5/7![Southwest logo]()
$304
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:11 pm
TYS
- SAT
1 stop4h 48m
American Airlines
Mon 6/15:52 pm
SAT
- TYS
1 stop4h 55m
American Airlines
Deal found 5/7![American Airlines logo]()
$274
This Frontier deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- SAT
1 stop23h 27m
Frontier
Tue 6/97:51 pm
SAT
- TYS
1 stop22h 46m
Frontier
Deal found 5/11![Frontier logo]()
$206
This Mytrip deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:32 pm
TYS
- SAT
1 stop23h 27m
Frontier
Sun 6/77:54 pm
SAT
- TYS
1 stop22h 39m
Frontier
Deal found 5/7![Frontier logo]()
$233
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:33 pm
TYS
- SAT
1 stop6h 33m
American Airlines
Sat 6/65:35 pm
SAT
- TYS
1 stop5h 20m
American Airlines
Deal found 5/8![American Airlines logo]()
$284
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:33 pm
TYS
- SAT
1 stop6h 11m
Delta
Sat 6/65:00 pm
SAT
- TYS
1 stop6h 01m
Delta
Deal found 5/10![Delta logo]()
$300
This Booking.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:32 pm
TYS
- SAT
1 stop23h 27m
Frontier
Sun 6/77:54 pm
SAT
- TYS
1 stop22h 39m
Frontier
Deal found 5/9![Frontier logo]()
$242
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:40 am
TYS
- SAT
1 stop5h 12m
Delta
Wed 6/245:25 am
SAT
- TYS
1 stop4h 44m
Delta
Deal found 5/10![Delta logo]()
$295
This Mytrip deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/228:32 pm
TYS
- SAT
1 stop23h 24m
Frontier
Thu 6/257:51 pm
SAT
- TYS
1 stop22h 46m
Frontier
Deal found 5/7![Frontier logo]()
$260
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/267:46 pm
TYS
- SAT
1 stop5h 47m
Delta
Tue 6/305:25 am
SAT
- TYS
1 stop4h 44m
Delta
Deal found 5/10![Delta logo]()
$293
One-way flights from Knoxville to San AntonioSearch for one-way flight options from Knoxville to San Antonio. Find affordable one-way fares based on user searches. Data last updated May 11, 2026.
Search for one-way flight options from Knoxville to San Antonio. Find affordable one-way fares based on user searches. Data last updated May 11, 2026.
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:07 pm
TYS
- SAT
1 stop5h 10m
American Airlines
Deal found 5/8![American Airlines logo]()
$129
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:50 pm
TYS
- SAT
2 stops8h 25m
Southwest
Deal found 5/8![Southwest logo]()
$144
This Mytrip deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:19 pm
TYS
- SAT
1 stop23h 40m
Frontier
Deal found 5/10![Frontier logo]()
$165
This Southwest deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:40 am
TYS
- SAT
2 stops8h 50m
Southwest
Deal found 5/6![Southwest logo]()
$214
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:55 pm
TYS
- SAT
1 stop5h 59m
United Airlines
Deal found 5/8![United Airlines logo]()
$215
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:35 am
TYS
- SAT
2 stops7h 40m
Southwest
Deal found 5/10![Southwest logo]()
$250
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:59 pm
TYS
- SAT
1 stop5h 32m
Delta
Deal found 5/9![Delta logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:01 pm
TYS
- SAT
3 stops30h 58m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$261
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:35 am
TYS
- SAT
2 stops7h 40m
Southwest
Deal found 5/9![Southwest logo]()
$274
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:00 am
TYS
- SAT
2 stops9h 39m
United Airlines
Deal found 5/6![United Airlines logo]()
$290
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:54 pm
TYS
- SAT
2 stops9h 50m
United Airlines
Deal found 5/8![United Airlines logo]()
$335
Find flight deals from Knoxville to San Antonio
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $206 (Frontier) |
One-way from | $129 (American Airlines) |
Popular in | June |
Cheapest in | July |
Average price | $328 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Fri 5/29
1:59 pm-8:28 pm
1 stop7h 29m
San Antonio
Tue 6/2
5:00 pm-12:01 am
1 stop6h 01m
$267
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Wed 6/3
7:33 pm-12:44 am
1 stop6h 11m
San Antonio
Sat 6/6
5:00 pm-12:01 am
1 stop6h 01m
$300
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Mon 6/1
6:45 pm-12:15 am
1 stop6h 30m
San Antonio
Tue 6/9
5:30 am-5:00 pm
2 stops10h 30m
$320
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Mon 6/15
7:45 pm-1:00 am
1 stop6h 15m
San Antonio
Wed 6/17
5:45 am-6:20 pm
1 stop11h 35m
$326
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Thu 7/2
6:08 pm-12:33 am
1 stop7h 25m
San Antonio
Sun 7/5
6:19 pm-11:54 pm
1 stop4h 35m
$326
Quickest round-trip
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Fri 8/7
2:05 pm-7:00 pm
1 stop5h 55m
San Antonio
Mon 8/10
7:00 am-11:55 am
1 stop3h 55m
$329
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Wed 5/27
12:50 pm-9:05 pm
1 stop9h 15m
San Antonio
Tue 6/2
7:00 am-5:10 pm
2 stops9h 10m
$339
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Wed 5/27
12:50 pm-8:15 pm
2 stops8h 25m
San Antonio
Wed 6/3
5:55 am-5:10 pm
1 stop10h 15m
$349
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Wed 6/3
12:50 pm-8:15 pm
2 stops8h 25m
San Antonio
Sat 6/6
11:40 am-6:20 pm
1 stop5h 40m
$377
Cheapest one-way
Quickest one-way
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Wed 5/27
6:07 pm-10:17 pm
1 stop5h 10m
$129
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Knoxville to San Antonio
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Antonio in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Antonio flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Antonio
Have a flexible travel schedule? Discover the best time to fly to San Antonio from Knoxville with our price prediction graph.
TYS-SAT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Antonio
How far ahead should I book a flight from Knoxville to San Antonio?
To ensure you get the cheapest price possible for a flight from Knoxville to San Antonio, you should look to book at least 6 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Knoxville to San Antonio?
Currently, July is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $242). Flying from Knoxville to San Antonio in June is currently the most expensive (average of $538). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to San Antonio?
Reviews of airlines servicing San Antonio
Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated May 11, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Knoxville to San Antonio to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreMike,Aug 2025
OKC - AUS
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Antonio?
Book flights to San Antonio if you plan to visit one of these locationsNew Braunfels
Kerrville
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Knoxville and San Antonio flights
Browse other Knoxville and San Antonio flight options. Last updated on May 11, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on May 11, 2026.
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Top 4 airlines flying from Knoxville to San Antonio
Discover the top 4 airlines that operate flights from Knoxville to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$207 | Average$338 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$216 | Average$512 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$232 | Average$338 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$335 | FlexibilityNo cancel fee | On-time69% |