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Des Moines

$119+ Cheap flights from Syracuse to Des Moines (SYR - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — DSM
May 28 — Jun 41
Thu 5/28
Thu 6/4
1 adult, Economy
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Cheap flight deals from Syracuse to Des Moines

Cheapest flights from Syracuse to Des Moines
Explore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/109:45 pm
SYR
-
DSM
1 stop26h 12m
Allegiant Air
Thu 5/147:45 am
DSM
-
SYR
1 stop8h 28m
Allegiant Air
Deal found 4/25$287
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/208:21 pm
SYR
-
DSM
1 stop4h 49m
American Airlines
Wed 6/241:37 pm
DSM
-
SYR
1 stop8h 15m
American Airlines
Deal found 4/25$311
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:41 pm
SYR
-
DSM
1 stop5h 09m
American Airlines
Sat 6/65:00 am
DSM
-
SYR
1 stop4h 27m
American Airlines
Deal found 4/28$325
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/179:45 pm
SYR
-
DSM
1 stop26h 12m
Multiple Airlines
Wed 5/272:16 pm
DSM
-
SYR
2 stops22h 41m
Multiple Airlines
Deal found 4/28$337
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:00 am
SYR
-
DSM
1 stop5h 52m
American Airlines
Mon 6/81:37 pm
DSM
-
SYR
1 stop8h 15m
American Airlines
Deal found 4/26$339
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:39 pm
SYR
-
DSM
1 stop23h 01m
Allegiant Air
Sun 5/177:45 am
DSM
-
SYR
1 stop8h 28m
Allegiant Air
Deal found 4/28$344
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/179:45 pm
SYR
-
DSM
1 stop26h 12m
Allegiant Air
Sun 5/249:43 am
DSM
-
SYR
1 stop22h 48m
Allegiant Air
Deal found 4/28$348
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:00 am
SYR
-
DSM
1 stop6h 08m
Delta
Tue 5/265:28 pm
DSM
-
SYR
1 stop4h 32m
Delta
Deal found 4/28$353
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:40 am
SYR
-
DSM
1 stop6h 50m
American Airlines
Tue 5/191:38 pm
DSM
-
SYR
1 stop8h 01m
American Airlines
Deal found 4/28$354
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/511:38 am
SYR
-
DSM
1 stop12h 49m
Multiple Airlines
Sun 6/76:00 am
DSM
-
SYR
2 stops11h 36m
Multiple Airlines
Deal found 4/25$367
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1512:14 pm
SYR
-
DSM
1 stop8h 20m
Delta
Sun 5/244:25 pm
DSM
-
SYR
1 stop5h 35m
Delta
Deal found 4/28$369
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:15 am
SYR
-
DSM
1 stop5h 22m
United Airlines
Sat 5/163:20 pm
DSM
-
SYR
2 stops7h 10m
United Airlines
Deal found 4/26$374

Find flight deals from Syracuse to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$287
(Kiwi.com)

One-way from

$119
(Kiwi.com)

Popular in

April

Cheapest in

September

Average price

$506
Provider with most accurate pricing for Syracuse Hancock Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Des Moines flights.
Search Deals
From Syracuse Hancock Intl to Des Moines
Search Deals
One-way flight from Syracuse Hancock Intl to Des Moines
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($47 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 5/15

7:39 pm-5:40 pm

1 stop23h 01m

Des Moines

Sun 5/17

7:45 am-5:13 pm

1 stop8h 28m

$344

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 6/5

11:38 am-11:27 pm

1 stop12h 49m

Des Moines

Sun 6/7

6:00 am-6:36 pm

2 stops11h 36m

$367

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Tue 5/12

6:15 am-10:37 am

1 stop5h 22m

Des Moines

Sat 5/16

3:20 pm-8:46 pm

1 stop4h 26m

$369

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 6/20

6:15 am-10:27 am

1 stop5h 12m

Des Moines

Wed 6/24

5:00 am-2:15 pm

2 stops8h 15m

$415
Quickest round-trip

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 5/16

6:20 am-9:46 am

1 stop4h 26m

Des Moines

Mon 5/18

5:56 pm-11:49 pm

1 stop4h 53m

$422

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 5/15

6:15 am-10:37 am

1 stop5h 22m

Des Moines

Tue 5/19

3:20 pm-11:30 pm

2 stops7h 10m

$430

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 5/9

2:27 pm-7:26 pm

1 stop5h 59m

Des Moines

Wed 5/13

11:40 am-4:48 pm

1 stop4h 08m

$449

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 6/18

8:32 pm-4:59 pm

1 stop21h 27m

Des Moines

Sun 6/21

6:00 am-2:09 pm

1 stop7h 09m

$464

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 5/21

6:15 am-10:27 am

1 stop5h 12m

Des Moines

Sun 5/24

6:00 am-2:15 pm

2 stops7h 15m

$478
Cheapest one-way

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 5/28

7:26 pm-11:24 pm

1 stop28h 58m

$119

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 16 resultsSorted by cheapest first
1
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Compare providers for flights from Syracuse to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Des Moines in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Syracuse-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Syracuse-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Syracuse to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Des Moines

What is the cheapest month to book a flight from Syracuse to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Syracuse to Des Moines (average of $308). Flying from Syracuse to Des Moines in April is currently the most expensive (average of $506). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Syracuse to Des Moines?

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 28, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Syracuse to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,465 reviews

Food

7.2

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,465 reviews
Delta
7.9
Good
8,465 reviews

Food

7.2

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
9,680 reviews
Delta
7.9
Good
8,465 reviews

Food

7.2

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.1
Good
11,678 reviews
Delta
7.9
Good
8,465 reviews

Food

7.2

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Syracuse to Des Moines?

    There are many flights that can get you from Syracuse to Des Moines in 4h 26m. Fly via Allegiant Air, Delta, or United Airlines to get the fastest option. The distance between Syracuse and Des Moines is about 901 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Syracuse to Des Moines round-trip?

    Currently priced at $258, American Airlines will fly you from Syracuse to Des Moines and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and United Airlines - these airlines can fly you to your destination from $258 and $301, respectively. You may be able to fly from Syracuse to Des Moines for 36% less than the average price by searching for these airlines.

  • Can I find deals for flights from Syracuse to Des Moines that include hotel bookings?

    Yes. In addition to deals on Syracuse to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Des Moines.

  • Can I find deals for business class flights from Syracuse to Des Moines?

    Yes. Cheapflights offers flight deals from Syracuse to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Syracuse to Des Moines (average of $308). Flying from Syracuse to Des Moines in April is currently the most expensive (average of $506). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Syracuse to Des Moines

Discover the top 3 airlines that operate flights from Syracuse to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$408FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$451FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$301Average$342FlexibilityNo cancel feeOn-time69%

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