$349+ Cheap flights from Des Moines to Syracuse (DSM - SYR)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SYR
Nov 25 — Dec 21
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Syracuse with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to SyracuseExplore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:11 pm -
1 stop3h 51m
Wed 12/306:10 am -
1 stop4h 45m
Deal found 10/26![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:11 pm -
1 stop4h 02m
Tue 12/296:00 am -
1 stop4h 55m
Deal found 10/22![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:27 pm -
1 stop8h 26m
Tue 11/175:20 pm -
1 stop6h 39m
Deal found 10/24![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:23 am -
2 stops8h 36m
Tue 11/175:33 pm -
1 stop5h 21m
Deal found 10/24![American Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1010:24 am -
1 stop4h 27m
Sat 11/146:07 am -
1 stop6h 41m
Deal found 10/26![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:22 am -
1 stop4h 17m
Sat 11/142:55 pm -
2 stops9h 04m
Deal found 10/26![United Airlines logo]()
$404
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am -
1 stop5h 12m
Mon 11/95:20 pm -
1 stop4h 23m
Deal found 10/23![Delta logo]()
$429
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/223:26 pm -
1 stop7h 33m
Tue 12/297:38 pm -
1 stop5h 20m
Deal found 10/22![American Airlines logo]()
$470
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/235:30 am -
2 stops9h 12m
Wed 12/306:00 am -
2 stops9h 56m
Deal found 10/26![American Airlines logo]()
$480
Best flights from Des Moines to SyracuseDiscover carefully curated flight deals from Des Moines to Syracuse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
Discover carefully curated flight deals from Des Moines to Syracuse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:11 pm -
1 stop4h 02m
Wed 12/306:00 am -
1 stop4h 55m
Deal found 10/24![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:27 pm -
1 stop8h 26m
Tue 11/175:20 pm -
1 stop6h 39m
Deal found 10/24![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:23 am -
2 stops8h 36m
Tue 11/176:00 am -
2 stops8h 28m
Deal found 10/24![American Airlines logo]()
$385
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/206:11 pm -
1 stop4h 02m
Sun 12/276:00 am -
1 stop4h 55m
Deal found 10/22![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:22 am -
1 stop4h 17m
Sat 11/142:55 pm -
2 stops9h 04m
Deal found 10/26![United Airlines logo]()
$404
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:11 pm -
1 stop4h 02m
Tue 12/296:00 am -
1 stop4h 55m
Deal found 10/22![Delta logo]()
$369
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/165:25 pm -
1 stop4h 33m
Fri 5/146:00 am -
1 stop4h 24m
Deal found 10/25![Delta logo]()
$384
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/271:35 pm -
1 stop9h 08m
Sat 1/305:24 pm -
1 stop6h 50m
Deal found 10/24![United Airlines logo]()
$449
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1010:24 am -
1 stop4h 27m
Sat 11/146:07 am -
1 stop6h 41m
Deal found 10/26![Delta logo]()
$399
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:11 pm -
1 stop4h 02m
Mon 12/286:00 am -
1 stop4h 55m
Deal found 10/22![Delta logo]()
$404
Last-minute flights from Des Moines to SyracuseDiscover last-minute flight deals from Des Moines to Syracuse. Data last updated October 26, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Syracuse. Data last updated October 26, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:05 am -
1 stop7h 05m
Mon 11/26:40 pm -
1 stop6h 46m
Deal found 10/22![American Airlines logo]()
$486
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:46 pm -
1 stop6h 43m
Mon 11/26:22 am -
1 stop4h 20m
Deal found 10/26![Delta logo]()
$499
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am -
1 stop5h 12m
Mon 11/95:20 pm -
1 stop4h 23m
Deal found 10/23![Delta logo]()
$429
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/61:27 pm -
1 stop8h 26m
Mon 11/92:55 pm -
2 stops8h 00m
Deal found 10/23![United Airlines logo]()
$485
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1010:24 am -
1 stop4h 27m
Sat 11/146:07 am -
1 stop6h 41m
Deal found 10/26![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:22 am -
1 stop4h 17m
Sat 11/142:55 pm -
2 stops9h 04m
Deal found 10/26![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:27 pm -
1 stop8h 26m
Tue 11/175:20 pm -
1 stop6h 39m
Deal found 10/24![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:23 am -
2 stops8h 36m
Tue 11/175:33 pm -
1 stop5h 21m
Deal found 10/24![American Airlines logo]()
$379
Find flight deals from Des Moines to Syracuse
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $293 (Kiwi.com) |
Popular in | April |
Cheapest in | February |
Average price | $403 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesSyracuse
DSM Des Moines - SYR Syracuse Hancock Intl
DSMSYR
Des Moines
Wed 12/23
6:11 pm-11:13 pm
1 stop4h 02m
Syracuse Hancock Intl
Wed 12/30
6:00 am-9:55 am
1 stop4h 55m
$349
Des MoinesSyracuse
DSM Des Moines - SYR Syracuse Hancock Intl
DSMSYR
Des Moines
Sun 12/20
6:11 pm-11:13 pm
1 stop4h 02m
Syracuse Hancock Intl
Sun 12/27
6:00 am-9:55 am
1 stop4h 55m
$369
Des MoinesSyracuse
DSM Des Moines - SYR Syracuse Hancock Intl
DSMSYR
Des Moines
Wed 12/23
6:11 pm-11:13 pm
1 stop4h 02m
Syracuse Hancock Intl
Tue 12/29
6:00 am-9:55 am
1 stop4h 55m
$369
Des MoinesSyracuse
DSM Des Moines - SYR Syracuse Hancock Intl
DSMSYR
Des Moines
Wed 11/11
1:27 pm-10:53 pm
1 stop8h 26m
Syracuse Hancock Intl
Tue 11/17
5:20 pm-10:59 pm
1 stop6h 39m
$374
Des MoinesSyracuse
DSM Des Moines - SYR Syracuse Hancock Intl
DSMSYR
Des Moines
Fri 4/16
5:25 pm-10:58 pm
1 stop4h 33m
Syracuse Hancock Intl
Fri 5/14
6:00 am-9:24 am
1 stop4h 24m
$384
Des MoinesSyracuse
DSM Des Moines - SYR Syracuse Hancock Intl
DSMSYR
Des Moines
Wed 11/11
7:23 am-4:59 pm
2 stops8h 36m
Syracuse Hancock Intl
Tue 11/17
6:00 am-1:28 pm
2 stops8h 28m
$385
Des MoinesSyracuse
DSM Des Moines - SYR Syracuse Hancock Intl
DSMSYR
Des Moines
Tue 11/10
10:24 am-3:51 pm
1 stop4h 27m
Syracuse Hancock Intl
Sat 11/14
6:07 am-11:48 am
1 stop6h 41m
$399
Des MoinesSyracuse
DSM Des Moines - SYR Syracuse Hancock Intl
DSMSYR
Des Moines
Tue 11/10
11:22 am-4:39 pm
1 stop4h 17m
Syracuse Hancock Intl
Sat 11/14
2:55 pm-10:59 pm
2 stops9h 04m
$404
Des MoinesSyracuse
DSM Des Moines - SYR Syracuse Hancock Intl
DSMSYR
Des Moines
Mon 12/21
6:11 pm-11:13 pm
1 stop4h 02m
Syracuse Hancock Intl
Mon 12/28
6:00 am-9:55 am
1 stop4h 55m
$404
Des MoinesSyracuse
DSM Des Moines - SYR Syracuse Hancock Intl
DSMSYR
Des Moines
Wed 1/27
1:35 pm-11:43 pm
1 stop9h 08m
Syracuse Hancock Intl
Sat 1/30
5:24 pm-11:14 pm
1 stop6h 50m
$449
Sorted by cheapest first
Compare providers for flights from Des Moines to Syracuse
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Syracuse in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Syracuse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Syracuse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Syracuse flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Syracuse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Syracuse
Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.
DSM-SYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Syracuse
What is the cheapest month to book a flight from Des Moines to Syracuse?
Currently, February is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $358). Flying from Des Moines to Syracuse in April is currently the most expensive (average of $658). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Syracuse?
Airfare is below average for this route at the moment.
Des Moines to Syracuse flights typically cost between $338 and $485 in January.The cheapest round-trip price found within the last 5 days was $293 on Allegiant Air (Jan 6-Jan 20).
Reviews of airlines servicing Syracuse
Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated October 26, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Des Moines to Syracuse by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Food
7.2
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Entertainment
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Food
7.2
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Entertainment
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Food
7.2
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Entertainment
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Food
7.2
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Syracuse?
Book flights to Syracuse if you plan to visit one of these locationsEast Syracuse
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Des Moines and Syracuse flights
Browse other Des Moines and Syracuse flight options. Last updated on October 26, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on October 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Syracuse
Explore flights to Syracuse departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 26, 2026.
Top 3 airlines flying from Des Moines to Syracuse
Discover the top 3 airlines that operate flights from Des Moines to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$275 | Average$396 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$326 | Average$436 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$328 | Average$391 | FlexibilityNo cancel fee | On-timeN/A |