How long is the flight from Des Moines to Syracuse?

A quick flight from Des Moines to Syracuse can take about 5h 11m. American Airlines provides one of the quickest options available for as low as $329. Des Moines and Syracuse are separated by a distance of 901 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

Our cheapest airline available from Des Moines to Syracuse is American Airlines. Our recent data shows that you can find tickets from as low as $258 on this airline. Additional options worth looking into are United Airlines and Delta, starting at $258 and $258 round-trip. American Airlines is priced at 39% lower than the current average price of a flight leaving 3 months from now.

In terms of precipitation, rainfall in Syracuse ranges from 2.1 - 3.8 inches per month. July is typically the wettest month, when rainfall can reach 3.8 in. February is typically the driest time to visit Syracuse when rainfall is around 2.1 in.

If weather is an important factor for your trip to Syracuse, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

What are the most popular airlines that fly from Des Moines to Syracuse?

American Airlines, Delta and United Airlines are the most popular airlines when flying from Des Moines to Syracuse.

What is the cheapest time of day to fly from DSM to SYR?

When flying from Des Moines to Syracuse, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Most accurate provider : When it comes to deals on Des Moines-Syracuse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Syracuse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Syracuse flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Syracuse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Syracuse?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.

Can I find deals for business class flights from Des Moines to Syracuse?

Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$277+ Cheap Flights from Des Moines to Syracuse

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Cheap flight deals from Des Moines to Syracuse

Cheapest

Best

Last-minute

One-way

Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.

Wed 9/306:00 am -

1 stop8h 00m

Mon 10/56:30 pm -

1 stop5h 13m

Deal found 9/5

$329

Wed 10/212:01 pm -

2 stops8h 58m

Sat 10/246:12 am -

1 stop7h 33m

Deal found 9/5

$334

Wed 10/216:00 am -

1 stop6h 01m

Wed 10/2812:10 pm -

1 stop8h 04m

Deal found 9/6

$349

Fri 10/235:50 pm -

1 stop4h 28m

Mon 10/265:20 pm -

1 stop4h 20m

Deal found 9/9

$384

Sat 11/149:25 am -

1 stop7h 41m

Sat 11/215:21 pm -

2 stops7h 58m

Deal found 9/9

$389

Tue 11/101:27 pm -

1 stop8h 26m

Sat 11/145:20 pm -

1 stop5h 35m

Deal found 9/8

$409

Best flights from Des Moines to Syracuse
Discover carefully curated flight deals from Des Moines to Syracuse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.

Wed 9/305:56 pm -

1 stop5h 11m

Mon 10/55:36 pm -

1 stop6h 09m

Deal found 9/8

$329

Wed 10/213:46 pm -

1 stop6h 43m

Sat 10/246:22 am -

1 stop4h 20m

Deal found 9/5

$349

Tue 11/101:27 pm -

1 stop8h 26m

Sat 11/145:20 pm -

1 stop5h 35m

Deal found 9/9

$409

Wed 10/212:01 pm -

2 stops8h 58m

Sat 10/245:27 pm -

2 stops7h 47m

Deal found 9/5

$339

Wed 10/216:00 am -

1 stop6h 01m

Wed 10/2812:10 pm -

1 stop8h 04m

Deal found 9/6

$349

Thu 10/226:00 am -

1 stop6h 01m

Thu 10/296:22 am -

1 stop4h 20m

Deal found 9/7

$349

Last-minute flights from Des Moines to Syracuse
Discover last-minute flight deals from Des Moines to Syracuse. Data last updated September 10, 2026 and is based on user searches.

Wed 9/306:00 am -

1 stop8h 00m

Mon 10/56:30 pm -

1 stop5h 13m

Deal found 9/5

$329

Wed 10/76:05 am -

1 stop7h 05m

Thu 10/155:36 pm -

2 stops7h 38m

Deal found 9/6

$420

Wed 10/212:01 pm -

2 stops8h 58m

Sat 10/246:12 am -

1 stop7h 33m

Deal found 9/5

$334

Wed 10/213:46 pm -

1 stop6h 43m

Sat 10/246:22 am -

1 stop4h 20m

Deal found 9/7

$349

Fri 10/235:50 pm -

1 stop4h 28m

Mon 10/265:20 pm -

1 stop4h 20m

Deal found 9/9

$384

Fri 10/236:05 am -

1 stop7h 05m

Mon 10/266:30 pm -

1 stop5h 13m

Deal found 9/7

$417

One-way flights from Des Moines to Syracuse
Search for one-way flight options from Des Moines to Syracuse. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.

Sun 9/209:56 pm -

1 stop21h 45m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/9

$277

Sat 10/103:11 pm -

2 stops7h 35m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/9

$314

Tue 9/225:56 pm -

1 stop5h 11m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/7

$384

Mon 9/219:31 pm -

3 stops59h 33m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/9

$385

Sat 9/1911:32 am -

1 stop4h 14m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/9

$387

Tue 9/226:24 am -

2 stops11h 43m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/7

$399

Mon 9/213:22 pm -

1 stop4h 37m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/9

$434

Sat 9/198:00 am -

3 stops25h 55m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/9

$459

Find flight deals from Des Moines to Syracuse

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$329 (American Airlines)
One-way from	$277 (Kiwi.com)
Popular in	April
Cheapest in	October
Average price	$328

Provider with most accurate pricing for Des Moines-Syracuse Hancock Intl flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Syracuse Hancock Intl flights.

Search Deals

From Des Moines to Syracuse Hancock Intl

Search Deals

One-way flight from Des Moines to Syracuse Hancock Intl

Search Deals

Highest demand for flights based on searches. 22% potential increase in price ($121 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2026

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Sat 10/10

3:11 pm-8:57 pm

1 stop4h 46m

Syracuse Hancock Intl

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$309

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Wed 9/30

5:56 pm-12:07 am

1 stop5h 11m

Syracuse Hancock Intl

Mon 10/5

5:36 pm-10:45 pm

1 stop6h 09m

$329

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Wed 10/21

2:01 pm-11:59 pm

2 stops8h 58m

Syracuse Hancock Intl

Sat 10/24

5:27 pm-12:14 am

2 stops7h 47m

$339

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Wed 10/21

3:46 pm-11:29 pm

1 stop6h 43m

Syracuse Hancock Intl

Sat 10/24

6:22 am-9:42 am

1 stop4h 20m

$349

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Wed 10/21

6:00 am-1:01 pm

1 stop6h 01m

Syracuse Hancock Intl

Wed 10/28

12:10 pm-7:14 pm

1 stop8h 04m

$349

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Thu 10/22

6:00 am-1:01 pm

1 stop6h 01m

Syracuse Hancock Intl

Thu 10/29

6:22 am-9:42 am

1 stop4h 20m

$349

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Sat 9/19

8:00 am-8:41 pm

3 stops59h 41m

Syracuse Hancock Intl

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$387

Quickest round-trip

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Sat 9/19

11:32 am-4:46 pm

1 stop4h 14m

Syracuse Hancock Intl

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$387

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Tue 9/22

6:24 am-7:07 pm

2 stops11h 43m

Syracuse Hancock Intl

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$399

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Tue 11/10

1:27 pm-10:53 pm

1 stop8h 26m

Syracuse Hancock Intl

Sat 11/14

5:20 pm-9:55 pm

1 stop5h 35m

$409

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 12 resultsSorted by cheapest first

Compare providers for flights from Des Moines to Syracuse

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Syracuse in September.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Syracuse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Syracuse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Syracuse flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Syracuse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.

DSM-SYR

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Syracuse

What is the cheapest month to book a flight from Des Moines to Syracuse?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $273). Flying from Des Moines to Syracuse in April is currently the most expensive (average of $658). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Syracuse

Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Des Moines to Syracuse by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.8

Good

8,554 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Delta

7.8

Good

8,554 reviews

Delta

7.8

Good

8,554 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

United Airlines

7.4

Good

10,194 reviews

Delta

7.8

Good

8,554 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

American Airlines

7.1

Good

12,045 reviews

Delta

7.8

Good

8,554 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

How long is the flight from Des Moines to Syracuse?
A quick flight from Des Moines to Syracuse can take about 5h 11m. American Airlines provides one of the quickest options available for as low as $329. Des Moines and Syracuse are separated by a distance of 901 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from Des Moines to Syracuse round-trip?
Our cheapest airline available from Des Moines to Syracuse is American Airlines. Our recent data shows that you can find tickets from as low as $258 on this airline. Additional options worth looking into are United Airlines and Delta, starting at $258 and $258 round-trip. American Airlines is priced at 39% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?
Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Syracuse?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.
Can I find deals for business class flights from Des Moines to Syracuse?
Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Syracuse?
Currently, October is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $273). Flying from Des Moines to Syracuse in April is currently the most expensive (average of $658). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

East Syracuse

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Complete your trip

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Popular flights

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Alternative routes for Des Moines to Syracuse

Top 3 airlines flying from Des Moines to Syracuse

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$258	Average$404	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$258	Average$388	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$258	Average$388	FlexibilityNo cancel fee	On-timeN/A

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$277+ Cheap flights from Des Moines to Syracuse (DSM - SYR)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/20. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Syracuse with Cheapflights

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Cheap flight deals from Des Moines to Syracuse

Cheapest flights from Des Moines to SyracuseExplore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.

Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.

Best flights from Des Moines to SyracuseDiscover carefully curated flight deals from Des Moines to Syracuse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.

Discover carefully curated flight deals from Des Moines to Syracuse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.

Last-minute flights from Des Moines to SyracuseDiscover last-minute flight deals from Des Moines to Syracuse. Data last updated September 10, 2026 and is based on user searches.

Discover last-minute flight deals from Des Moines to Syracuse. Data last updated September 10, 2026 and is based on user searches.

One-way flights from Des Moines to SyracuseSearch for one-way flight options from Des Moines to Syracuse. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.

Search for one-way flight options from Des Moines to Syracuse. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.

Find flight deals from Des Moines to Syracuse

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Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Compare providers for flights from Des Moines to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Syracuse in September.

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.

Cheapflights Insights

What is the cheapest month to book a flight from Des Moines to Syracuse?

Reviews of airlines servicing Syracuse

Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Des Moines to Syracuse by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

How long is the flight from Des Moines to Syracuse?

What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

How can I find direct flights from Des Moines to Syracuse?

Can I find deals for business class flights from Des Moines to Syracuse?

What is the cheapest month to book a flight from Des Moines to Syracuse?

Traveling to a place near Syracuse?

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Alternative routes for Des Moines to Syracuse

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Complete your trip

Complete your trip to Syracuse by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Des Moines to Syracuse by cabin class

Find flights from Des Moines to Syracuse, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Des Moines and Syracuse flights

Browse other Des Moines and Syracuse flight options. Last updated on September 10, 2026.

Other flights from Des Moines

Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.

Popular flight searches

Check out other popular destinations found by fellow travelers in 2026

Other flights to Syracuse

Explore flights to Syracuse departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.

Top 3 airlines flying from Des Moines to Syracuse

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Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.

Best flights from Des Moines to Syracuse
Discover carefully curated flight deals from Des Moines to Syracuse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.

Last-minute flights from Des Moines to Syracuse
Discover last-minute flight deals from Des Moines to Syracuse. Data last updated September 10, 2026 and is based on user searches.

One-way flights from Des Moines to Syracuse
Search for one-way flight options from Des Moines to Syracuse. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.