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Syracuse

$126+ Cheap flights from Des Moines to Syracuse (DSM - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SYR
Jul 13 — Jul 201
Mon 7/13
Mon 7/20
1 adult, Economy
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Cheap flight deals from Des Moines to Syracuse

Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2026.

This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/77:05 pm
DSM
-
SYR
1 stop15h 15m
Allegiant Air
Sun 8/97:26 pm
SYR
-
DSM
1 stop22h 51m
Allegiant Air
Deal found 6/13$298
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:33 pm
DSM
-
SYR
1 stop4h 30m
American Airlines
Wed 7/158:19 pm
SYR
-
DSM
1 stop4h 42m
American Airlines
Deal found 6/11$319
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:30 pm
DSM
-
SYR
1 stop16h 30m
Allegiant Air
Sun 7/267:26 pm
SYR
-
DSM
1 stop21h 24m
Allegiant Air
Deal found 6/9$322
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/92:29 pm
DSM
-
SYR
2 stops8h 18m
American Airlines
Wed 9/165:00 pm
SYR
-
DSM
1 stop5h 47m
American Airlines
Deal found 6/12$324
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1410:00 am
DSM
-
SYR
1 stop26h 48m
Allegiant Air
Sun 8/2311:48 am
SYR
-
DSM
1 stop22h 26m
Allegiant Air
Deal found 6/10$350
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:30 pm
DSM
-
SYR
1 stop16h 30m
Allegiant Air
Sun 7/127:26 pm
SYR
-
DSM
1 stop21h 24m
Allegiant Air
Deal found 6/12$364
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:30 pm
DSM
-
SYR
1 stop16h 30m
Allegiant Air
Sun 8/27:26 pm
SYR
-
DSM
1 stop21h 24m
Allegiant Air
Deal found 6/13$367
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/223:20 pm
DSM
-
SYR
1 stop4h 45m
United Airlines
Sat 8/295:48 pm
SYR
-
DSM
1 stop4h 35m
United Airlines
Deal found 6/10$368

Find flight deals from Des Moines to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$298
(Kiwi.com)

One-way from

$126
(Kiwi.com)

Popular in

April

Cheapest in

September

Average price

$396
Provider with most accurate pricing for Des Moines-Syracuse Hancock Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Syracuse Hancock Intl flights.
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From Des Moines to Syracuse Hancock Intl
Search Deals
One-way flight from Des Moines to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($149 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 9/9

5:25 pm-10:56 pm

1 stop4h 31m

Syracuse Hancock Intl

Wed 9/16

12:11 pm-7:15 pm

1 stop8h 04m

$329

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 9/1

3:20 pm-9:32 pm

1 stop5h 12m

Syracuse Hancock Intl

Sat 9/5

6:15 am-10:26 am

1 stop5h 11m

$399

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 8/29

3:20 pm-9:05 pm

1 stop4h 45m

Syracuse Hancock Intl

Wed 9/2

6:10 am-10:26 am

1 stop5h 16m

$409

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 7/24

5:32 pm-10:58 pm

1 stop4h 26m

Syracuse Hancock Intl

Mon 7/27

12:16 pm-7:15 pm

1 stop7h 59m

$423
Quickest round-trip

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 7/16

5:00 am-10:12 am

1 stop4h 12m

Syracuse Hancock Intl

Mon 7/20

8:19 pm-12:01 am

1 stop4h 42m

$459

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 7/8

6:00 am-2:15 pm

2 stops7h 15m

Syracuse Hancock Intl

Wed 7/15

6:15 am-10:17 am

1 stop5h 02m

$465

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 7/2

3:24 pm-9:09 pm

1 stop4h 45m

Syracuse Hancock Intl

Mon 7/6

5:49 pm-10:55 pm

1 stop6h 06m

$494

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 7/23

6:00 am-2:04 pm

2 stops7h 04m

Syracuse Hancock Intl

Sat 7/25

5:49 pm-9:28 pm

1 stop4h 39m

$508
Cheapest one-way

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 8/7

7:05 pm-11:20 am

1 stop15h 15m

$126

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 7/10

5:30 pm-11:00 am

1 stop16h 30m

$129

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/13

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Syracuse in June.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Syracuse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Syracuse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Syracuse flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Syracuse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Syracuse

What is the cheapest month to book a flight from Des Moines to Syracuse?

Currently, September is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $258). Flying from Des Moines to Syracuse in April is currently the most expensive (average of $658). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Syracuse?

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated June 13, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Des Moines to Syracuse by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,406 reviews

Food

7.2

Boarding

8.1

Comfort

7.8

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,406 reviews
Delta
7.9
Good
8,406 reviews

Food

7.2

Boarding

8.1

Comfort

7.8

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
United Airlines
7.4
Good
9,815 reviews
Delta
7.9
Good
8,406 reviews

Food

7.2

Boarding

8.1

Comfort

7.8

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.1
Good
11,649 reviews
Delta
7.9
Good
8,406 reviews

Food

7.2

Boarding

8.1

Comfort

7.8

Entertainment

7.8

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Syracuse?

    A quick flight from Des Moines to Syracuse can take about 4h 31m. Delta provides one of the quickest options available for as low as $329. Des Moines and Syracuse are separated by a distance of 901 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

    Our cheapest airline available from Des Moines to Syracuse is American Airlines. Our recent data shows that you can find tickets from as low as $258 on this airline. Additional options worth looking into are United Airlines and Delta, starting at $258 and $258 round-trip. American Airlines is priced at 35% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

    Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.

  • Can I find deals for business class flights from Des Moines to Syracuse?

    Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Syracuse?

    Currently, September is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $258). Flying from Des Moines to Syracuse in April is currently the most expensive (average of $658). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
East Syracuse
Liverpool

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Top 3 airlines flying from Des Moines to Syracuse

Discover the top 3 airlines that operate flights from Des Moines to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$258Average$404FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$258Average$382FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$383FlexibilityNo cancel feeOn-timeN/A

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