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Syracuse

$309+ Cheap flights from Des Moines to Syracuse (DSM - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SYR
Aug 25 — Sep 11
Tue 8/25
Tue 9/1
1 adult, Economy
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Cheap flight deals from Des Moines to Syracuse

Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 26, 2026.

This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:00 am
DSM
-
SYR
1 stop4h 51m
American Airlines
Sat 9/121:05 pm
SYR
-
DSM
1 stop5h 22m
American Airlines
Deal found 7/22$317
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:04 pm
DSM
-
SYR
1 stop18h 33m
Multiple Airlines
Thu 10/227:29 pm
SYR
-
DSM
1 stop13h 40m
Multiple Airlines
Deal found 7/22$327
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/281:09 pm
DSM
-
SYR
1 stop4h 47m
American Airlines
Sun 8/307:58 am
SYR
-
DSM
1 stop5h 36m
American Airlines
Deal found 7/25$329
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/281:35 pm
DSM
-
SYR
1 stop8h 46m
United Airlines
Sun 8/306:00 am
SYR
-
DSM
2 stops7h 20m
United Airlines
Deal found 7/25$334
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am
DSM
-
SYR
2 stops7h 19m
United Airlines
Tue 10/2010:29 am
SYR
-
DSM
2 stops8h 19m
United Airlines
Deal found 7/23$339
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:00 am
DSM
-
SYR
2 stops7h 04m
United Airlines
Sun 8/96:15 am
SYR
-
DSM
1 stop5h 02m
United Airlines
Deal found 7/23$384
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
DSM
-
SYR
1 stop4h 50m
American Airlines
Thu 8/208:29 pm
SYR
-
DSM
1 stop4h 51m
American Airlines
Deal found 7/24$385
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
DSM
-
SYR
2 stops7h 15m
United Airlines
Thu 8/206:12 am
SYR
-
DSM
1 stop5h 14m
United Airlines
Deal found 7/24$390

Find flight deals from Des Moines to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$317
(American Airlines)

One-way from

$309
(United Airlines)

Popular in

April

Cheapest in

September

Average price

$388
Provider with most accurate pricing for Des Moines-Syracuse Hancock Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Syracuse Hancock Intl flights.
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From Des Moines to Syracuse Hancock Intl
Search Deals
One-way flight from Des Moines to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 25% potential increase in price ($140 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 26, 2026.
Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 9/5

6:00 am-11:51 am

1 stop4h 51m

Syracuse Hancock Intl

Sat 9/12

1:05 pm-5:27 pm

1 stop5h 22m

$317

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 10/17

1:27 pm-11:36 pm

1 stop9h 09m

Syracuse Hancock Intl

Tue 10/20

6:10 am-10:31 am

1 stop5h 21m

$329

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 8/28

1:09 pm-6:56 pm

1 stop4h 47m

Syracuse Hancock Intl

Sun 8/30

7:58 am-12:34 pm

1 stop5h 36m

$329
Quickest round-trip

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 8/5

6:00 am-11:50 am

1 stop4h 50m

Syracuse Hancock Intl

Thu 8/20

8:29 pm-12:20 am

1 stop4h 51m

$385

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 8/5

6:00 am-2:15 pm

2 stops7h 15m

Syracuse Hancock Intl

Thu 8/20

6:12 am-10:26 am

1 stop5h 14m

$390

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 8/28

6:00 am-2:03 pm

2 stops7h 03m

Syracuse Hancock Intl

Sun 8/30

6:00 am-12:20 pm

2 stops7h 20m

$401

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 8/7

6:00 am-11:50 am

1 stop4h 50m

Syracuse Hancock Intl

Wed 8/12

6:05 am-9:56 am

1 stop4h 51m

$424

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 9/17

6:24 am-2:29 pm

2 stops7h 05m

Syracuse Hancock Intl

Sun 9/20

6:10 am-10:31 am

1 stop5h 21m

$473

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 8/6

6:00 am-2:04 pm

2 stops7h 04m

Syracuse Hancock Intl

Sun 8/9

2:40 pm-10:56 pm

2 stops9h 16m

$495
Cheapest one-way
Quickest one-way

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 8/22

3:20 pm-9:32 pm

1 stop5h 12m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/25

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Syracuse in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Syracuse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Syracuse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Syracuse flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Syracuse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Syracuse

How much does it cost to fly round-trip from Des Moines to Syracuse?

Airfare is below average for this route at the moment.

Des Moines to Syracuse flights typically cost between $382 and $520 in September.
The cheapest round-trip price found within the last 5 days was $317 on American Airlines (Sep 5-Sep 12).

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated July 26, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Des Moines to Syracuse by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,486 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Overall

7.8

Crew

8.5

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.8
Good
8,486 reviews
Delta
7.8
Good
8,486 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Overall

7.8

Crew

8.5

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
United Airlines
7.4
Good
10,034 reviews
Delta
7.8
Good
8,486 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Overall

7.8

Crew

8.5

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.1
Good
11,847 reviews
Delta
7.8
Good
8,486 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Overall

7.8

Crew

8.5

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Syracuse?

    A quick flight from Des Moines to Syracuse can take about 4h 51m. American Airlines provides one of the quickest options available for as low as $317. Des Moines and Syracuse are separated by a distance of 901 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

    Our cheapest airline available from Des Moines to Syracuse is American Airlines. Our recent data shows that you can find tickets from as low as $258 on this airline. Additional options worth looking into are United Airlines and Delta, starting at $258 and $258 round-trip. American Airlines is priced at 37% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

    Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.

  • Can I find deals for business class flights from Des Moines to Syracuse?

    Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
East Syracuse
Liverpool

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Top 3 airlines flying from Des Moines to Syracuse

Discover the top 3 airlines that operate flights from Des Moines to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$258Average$436FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$258Average$388FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$388FlexibilityNo cancel feeOn-timeN/A

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