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$119+ Cheap flights from Des Moines to Buffalo (DSM - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
jul. 8 — jul. 151
mar. 7/8
mar. 7/15
1 adult, Economy
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Cheap flight deals from Des Moines to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated julio 3, 2025.

Round-trip from

$237
(American Airlines)

One-way from

$119
(Delta)

Popular in

December

Cheapest in

November

Average price

$359
From Des Moines to Buffalo
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One-way flight from Des Moines to Buffalo
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Highest demand for flights based on searches. 16% potential increase in price ($83 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 3, 2025.

This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/146:12 pmDSM - BUF
1 stop4h 57mAmerican Airlines
lun. 8/186:33 pmBUF - DSM
1 stop5h 25mAmerican Airlines
Deal found 7/3$237
This Southwest deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/166:10 amDSM - BUF
1 stop7h 25mSouthwest
mar. 8/191:20 pmBUF - DSM
2 stops9h 05mSouthwest
Deal found 7/3$264
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/143:38 pmDSM - BUF
1 stop4h 23mUnited Airlines
jue. 8/217:05 amBUF - DSM
2 stops10h 08mUnited Airlines
Deal found 7/1$286
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/176:00 amDSM - BUF
1 stop4h 26mDelta
dom. 8/246:20 amBUF - DSM
1 stop4h 17mDelta
Deal found 7/3$367
This Mytrip deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/33:29 pmDSM - BUF
2 stops18h 15mMultiple Airlines
dom. 8/1011:41 amBUF - DSM
2 stops11h 57mMultiple Airlines
Deal found 7/1$465

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 3, 2025.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Des Moines

Fly to

Buffalo

Route

Depart

Return

Price

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jue. 8/14

6:12 pm-12:09 am

1 stop4h 57m

Buffalo

lun. 8/18

6:33 pm-10:58 pm

1 stop5h 25m

$237

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

sáb. 8/16

6:10 am-2:35 pm

1 stop7h 25m

Buffalo

mar. 8/19

1:20 pm-9:25 pm

2 stops9h 05m

$264

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jue. 8/14

3:38 pm-9:01 pm

1 stop4h 23m

Buffalo

jue. 8/21

7:05 am-4:13 pm

2 stops10h 08m

$286

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

dom. 8/17

6:00 am-11:26 am

1 stop4h 26m

Buffalo

dom. 8/24

6:20 am-9:37 am

1 stop4h 17m

$367

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

dom. 8/3

3:29 pm-10:44 am

2 stops18h 15m

Buffalo

dom. 8/10

11:41 am-10:38 pm

2 stops11h 57m

$465

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jue. 8/21

6:00 am-11:26 am

1 stop4h 26m

$119

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

vie. 8/15

8:17 am-1:50 pm

1 stop4h 33m

$163

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jue. 8/21

3:23 pm-9:27 am

2 stops17h 04m

$198

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

mar. 7/15

6:24 am-2:12 pm

2 stops6h 48m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Buffalo

What is the cheapest month to book a flight from Des Moines to Buffalo?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $256). Flying from Des Moines to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated julio 3, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,270 reviews

Crew

8.6

Food

7.0

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,270 reviews
Southwest
8.0
Very good
4,270 reviews

Crew

8.6

Food

7.0

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,970 reviews
Southwest
8.0
Very good
4,270 reviews

Crew

8.6

Food

7.0

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,845 reviews
Southwest
8.0
Very good
4,270 reviews

Crew

8.6

Food

7.0

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,270 reviews

Crew

8.6

Food

7.0

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Frontier
5.9
Fair
3,284 reviews
Southwest
8.0
Very good
4,270 reviews

Crew

8.6

Food

7.0

Entertainment

7.6

Comfort

8.0

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Buffalo round-trip?

    American Airlines, at $237, was found to be the cheapest airline from Des Moines to Buffalo.Alternate airlines to your destination round-trip include Southwest and United Airlines. These flights start at 45% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Buffalo one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $119. However, be on the lookout for offers from American Airlines and Frontier, as they are both options that can get you from Des Moines to Buffalo for a low price.

  • Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.

  • Can I find deals for business class flights from Des Moines to Buffalo?

    Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $256). Flying from Des Moines to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Williamsville
Orchard Park
Batavia
Eden
Amherst
West Seneca

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Top 3 airlines flying from Des Moines to Buffalo

Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$214Average$346FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$292Average$356FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$341Average$447FlexibilityNo cancel feeOn-time69%

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