$204+ Cheap flights from Buffalo to Des Moines (BUF - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/18. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — DSM
Jun 1 — Jun 81
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Des Moines
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Best
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Cheapest flights from Buffalo to Des MoinesExplore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 2, 2026.
Explore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 2, 2026.
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/38:01 am
BUF
- DSM
1 stop6h 04m
American Airlines
Wed 7/87:04 am
DSM
- BUF
1 stop5h 02m
American Airlines
Deal found 5/2![American Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:25 am
BUF
- DSM
1 stop7h 27m
American Airlines
Sun 6/71:47 pm
DSM
- BUF
1 stop7h 05m
American Airlines
Deal found 4/27![American Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:50 pm
BUF
- DSM
2 stops9h 40m
Southwest
Wed 7/85:20 am
DSM
- BUF
1 stop4h 05m
Southwest
Deal found 5/2![Southwest logo]()
$400
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/207:30 pm
BUF
- DSM
1 stop5h 40m
American Airlines
Sun 6/217:13 pm
DSM
- BUF
1 stop4h 25m
American Airlines
Deal found 4/30![American Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:21 pm
BUF
- DSM
2 stops7h 14m
American Airlines
Sun 6/217:13 pm
DSM
- BUF
1 stop4h 25m
American Airlines
Deal found 5/2![American Airlines logo]()
$412
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1110:54 am
BUF
- DSM
1 stop4h 11m
United Airlines
Wed 8/123:24 pm
DSM
- BUF
1 stop4h 44m
United Airlines
Deal found 4/27![United Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/192:30 pm
BUF
- DSM
1 stop6h 03m
Delta
Sun 6/216:08 am
DSM
- BUF
1 stop4h 16m
Delta
Deal found 4/28![Delta logo]()
$423
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/53:00 pm
BUF
- DSM
2 stops9h 45m
Southwest
Thu 7/94:40 pm
DSM
- BUF
2 stops6h 30m
Southwest
Deal found 5/2![Southwest logo]()
$427
Best flights from Buffalo to Des MoinesDiscover carefully curated flight deals from Buffalo to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 2, 2026.
Discover carefully curated flight deals from Buffalo to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 2, 2026.
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:25 am
BUF
- DSM
1 stop7h 27m
American Airlines
Sun 6/71:47 pm
DSM
- BUF
1 stop7h 05m
American Airlines
Deal found 4/27![American Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:50 pm
BUF
- DSM
2 stops9h 40m
Southwest
Wed 7/85:20 am
DSM
- BUF
1 stop4h 05m
Southwest
Deal found 5/2![Southwest logo]()
$400
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/57:00 am
BUF
- DSM
1 stop4h 27m
United Airlines
Thu 7/93:24 pm
DSM
- BUF
1 stop4h 39m
United Airlines
Deal found 5/2![United Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/192:30 pm
BUF
- DSM
1 stop6h 03m
Delta
Mon 6/225:34 pm
DSM
- BUF
1 stop5h 29m
Delta
Deal found 4/29![Delta logo]()
$423
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/77:10 pm
BUF
- DSM
1 stop4h 00m
Southwest
Mon 8/105:40 am
DSM
- BUF
2 stops10h 10m
Southwest
Deal found 4/30![Southwest logo]()
$412
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1110:54 am
BUF
- DSM
1 stop4h 11m
United Airlines
Wed 8/123:24 pm
DSM
- BUF
1 stop4h 44m
United Airlines
Deal found 4/28![United Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:29 am
BUF
- DSM
1 stop4h 15m
Delta
Sun 6/216:08 am
DSM
- BUF
1 stop4h 16m
Delta
Deal found 5/1![Delta logo]()
$423
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:00 am
BUF
- DSM
1 stop4h 37m
United Airlines
Sat 5/231:18 pm
DSM
- BUF
1 stop6h 45m
United Airlines
Deal found 5/2![United Airlines logo]()
$431
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/53:00 pm
BUF
- DSM
2 stops9h 45m
Southwest
Thu 7/95:10 am
DSM
- BUF
1 stop4h 15m
Southwest
Deal found 5/2![Southwest logo]()
$432
Last-minute flights from Buffalo to Des MoinesDiscover last-minute flight deals from Buffalo to Des Moines. Data last updated May 2, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Des Moines. Data last updated May 2, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:00 am
BUF
- DSM
1 stop4h 37m
United Airlines
Sat 5/163:20 pm
DSM
- BUF
1 stop4h 41m
United Airlines
Deal found 4/29![United Airlines logo]()
$487
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:00 am
BUF
- DSM
1 stop4h 37m
United Airlines
Sat 5/231:18 pm
DSM
- BUF
1 stop6h 45m
United Airlines
Deal found 5/2![United Airlines logo]()
$431
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/29:00 am
BUF
- DSM
1 stop8h 15m
United Airlines
Tue 6/911:26 am
DSM
- BUF
1 stop4h 15m
United Airlines
Deal found 5/2![United Airlines logo]()
$415
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:25 am
BUF
- DSM
1 stop7h 27m
American Airlines
Sun 6/71:47 pm
DSM
- BUF
1 stop7h 05m
American Airlines
Deal found 4/27![American Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/311:55 am
BUF
- DSM
2 stops11h 15m
Southwest
Sun 6/75:10 am
DSM
- BUF
2 stops8h 15m
Southwest
Deal found 4/27![Southwest logo]()
$452
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:21 pm
BUF
- DSM
2 stops7h 14m
American Airlines
Sun 6/217:13 pm
DSM
- BUF
1 stop4h 25m
American Airlines
Deal found 5/2![American Airlines logo]()
$412
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/192:30 pm
BUF
- DSM
1 stop6h 03m
Delta
Sun 6/216:08 am
DSM
- BUF
1 stop4h 16m
Delta
Deal found 4/28![Delta logo]()
$423
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:21 pm
BUF
- DSM
2 stops7h 14m
American Airlines
Mon 6/221:37 pm
DSM
- BUF
1 stop7h 58m
American Airlines
Deal found 4/29![American Airlines logo]()
$448
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/207:30 pm
BUF
- DSM
1 stop5h 40m
American Airlines
Sun 6/217:13 pm
DSM
- BUF
1 stop4h 25m
American Airlines
Deal found 4/30![American Airlines logo]()
$407
One-way flights from Buffalo to Des MoinesSearch for one-way flight options from Buffalo to Des Moines. Find affordable one-way fares based on user searches. Data last updated May 2, 2026.
Search for one-way flight options from Buffalo to Des Moines. Find affordable one-way fares based on user searches. Data last updated May 2, 2026.
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/188:01 am
BUF
- DSM
1 stop6h 02m
American Airlines
Deal found 4/30![American Airlines logo]()
$204
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:55 pm
BUF
- DSM
1 stop4h 35m
Southwest
Deal found 4/30![Southwest logo]()
$244
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1810:34 am
BUF
- DSM
2 stops9h 51m
United Airlines
Deal found 5/1![United Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:44 pm
BUF
- DSM
2 stops14h 49m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$263
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:55 pm
BUF
- DSM
1 stop4h 40m
United Airlines
Deal found 5/1![United Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:36 am
BUF
- DSM
3 stops57h 37m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:50 pm
BUF
- DSM
3 stops44h 17m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/93:04 pm
BUF
- DSM
1 stop5h 29m
American Airlines
Deal found 4/30![American Airlines logo]()
$349
Find flight deals from Buffalo to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $375 (American Airlines) |
One-way from | $204 (American Airlines) |
Popular in | March |
Cheapest in | June |
Average price | $385 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 2, 2026.
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Wed 6/3
6:25 am-12:52 pm
1 stop7h 27m
Des Moines
Sun 6/7
1:47 pm-9:52 pm
1 stop7h 05m
$379
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Fri 7/3
2:50 pm-11:30 pm
2 stops9h 40m
Des Moines
Wed 7/8
5:20 am-10:25 am
1 stop4h 05m
$400
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Sun 7/5
7:00 am-10:27 am
1 stop4h 27m
Des Moines
Thu 7/9
3:24 pm-9:03 pm
1 stop4h 39m
$407
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Fri 8/7
7:10 pm-10:10 pm
1 stop4h 00m
Des Moines
Mon 8/10
5:40 am-4:50 pm
2 stops10h 10m
$412
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Tue 8/11
10:54 am-2:05 pm
1 stop4h 11m
Des Moines
Wed 8/12
3:24 pm-9:08 pm
1 stop4h 44m
$415
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Fri 6/19
2:30 pm-7:33 pm
1 stop6h 03m
Des Moines
Mon 6/22
5:34 pm-12:03 am
1 stop5h 29m
$423
Quickest round-trip
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Fri 6/19
6:29 am-9:44 am
1 stop4h 15m
Des Moines
Sun 6/21
6:08 am-11:24 am
1 stop4h 16m
$423
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Sun 5/17
7:00 am-10:37 am
1 stop4h 37m
Des Moines
Sat 5/23
1:18 pm-9:03 pm
1 stop6h 45m
$431
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Sun 7/5
3:00 pm-11:45 pm
2 stops9h 45m
Des Moines
Thu 7/9
5:10 am-10:25 am
1 stop4h 15m
$432
Cheapest one-way
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Sat 7/18
8:01 am-1:03 pm
1 stop6h 02m
$204
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Des Moines in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Buffalo with our price prediction graph.
BUF-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated May 2, 2026.
Read through reviews of airlines operating flights from Buffalo to Des Moines, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Boarding
8.1
Food
7.2
Entertainment
7.8
Crew
8.5
Comfort
7.9
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.9
Boarding
8.1
Food
7.2
Entertainment
7.8
Crew
8.5
Comfort
7.9
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.9
Boarding
8.1
Food
7.2
Entertainment
7.8
Crew
8.5
Comfort
7.9
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny
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Buffalo and Des Moines flights
Browse other Buffalo and Des Moines flight options. Last updated on May 2, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on May 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Buffalo to Des Moines
Discover the top 2 airlines that operate flights from Buffalo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$427 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$319 | Average$479 | FlexibilityNo cancel fee | On-timeN/A |