$194+ Cheap flights from Buffalo to Des Moines (BUF - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/6. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — DSM
Oct 12 — Oct 191
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Buffalo to Des MoinesExplore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 12, 2026.
Explore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 12, 2026.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:00 am -
1 stop6h 45m
Sun 10/116:02 am -
1 stop7h 23m
Deal found 9/8![American Airlines logo]()
$371
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am -
1 stop4h 31m
Wed 10/211:24 pm -
1 stop6h 23m
Deal found 9/10![United Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:27 am -
1 stop4h 52m
Tue 9/296:00 am -
1 stop6h 53m
Deal found 9/9![American Airlines logo]()
$411
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:00 pm -
2 stops7h 40m
Sun 10/115:30 am -
2 stops10h 05m
Deal found 9/8![Southwest logo]()
$472
Best flights from Buffalo to Des MoinesDiscover carefully curated flight deals from Buffalo to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 12, 2026.
Discover carefully curated flight deals from Buffalo to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 12, 2026.
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am -
1 stop4h 31m
Wed 10/211:24 pm -
1 stop6h 23m
Deal found 9/10![United Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:27 am -
1 stop4h 52m
Tue 9/297:05 am -
2 stops9h 09m
Deal found 9/7![American Airlines logo]()
$447
Last-minute flights from Buffalo to Des MoinesDiscover last-minute flight deals from Buffalo to Des Moines. Data last updated September 12, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Des Moines. Data last updated September 12, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:27 am -
1 stop4h 52m
Tue 9/296:00 am -
1 stop6h 53m
Deal found 9/9![American Airlines logo]()
$411
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:00 am -
1 stop6h 45m
Sun 10/116:02 am -
1 stop7h 23m
Deal found 9/8![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:00 pm -
2 stops7h 40m
Sun 10/115:30 am -
2 stops10h 05m
Deal found 9/8![Southwest logo]()
$472
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am -
1 stop4h 31m
Wed 10/211:24 pm -
1 stop6h 23m
Deal found 9/10![United Airlines logo]()
$405
One-way flights from Buffalo to Des MoinesSearch for one-way flight options from Buffalo to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 12, 2026.
Search for one-way flight options from Buffalo to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 12, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:57 pm -
1 stop5h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![American Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:51 pm -
3 stops44h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:49 pm -
2 stops26h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/161:40 pm -
2 stops32h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:40 pm -
2 stops31h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:56 pm -
1 stop6h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:55 pm -
2 stops7h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:09 pm -
1 stop6h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$499
Find flight deals from Buffalo to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $371 (American Airlines) |
One-way from | $194 (American Airlines) |
Popular in | March |
Cheapest in | April |
Average price | $646 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 12, 2026.
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Tue 10/6
5:57 pm-10:45 pm
1 stop5h 48m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$194
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Tue 10/6
6:51 pm-2:42 pm
3 stops44h 51m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$201
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Wed 9/16
1:40 pm-9:06 pm
2 stops32h 26m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$322
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Mon 9/21
3:53 pm-8:46 pm
1 stop5h 53m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$394
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Sun 9/20
6:10 am-2:20 pm
2 stops9h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$399
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Tue 10/20
7:00 am-10:31 am
1 stop4h 31m
Des Moines
Wed 10/21
1:24 pm-8:47 pm
1 stop6h 23m
$405
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Sun 9/27
6:27 am-10:19 am
1 stop4h 52m
Des Moines
Tue 9/29
7:05 am-5:14 pm
2 stops9h 09m
$447
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Wed 9/16
12:09 pm-5:26 pm
1 stop6h 17m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$499
Sorted by cheapest first
Compare providers for flights from Buffalo to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Buffalo with our price prediction graph.
BUF-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 12, 2026.
Read through reviews of airlines operating flights from Buffalo to Des Moines, such as United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.4
Crew
8.1
Entertainment
7.1
Food
6.7
Boarding
7.7
Comfort
7.3
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Overall
7.4
Crew
8.1
Entertainment
7.1
Food
6.7
Boarding
7.7
Comfort
7.3
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Top airline flying from Buffalo to Des Moines
Discover the top airline that operate flights from Buffalo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$335 | Average$566 | FlexibilityNo cancel fee | On-time69% |