$152+ Cheap flights from Buffalo to Des Moines (BUF - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — DSM
Aug 29 — Sep 51
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Des Moines
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Best
Last-minute
One-way
Cheapest flights from Buffalo to Des MoinesExplore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
Explore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:55 am
BUF
- DSM
1 stop6h 25m
United Airlines
Sat 8/2211:32 am
DSM
- BUF
1 stop4h 20m
United Airlines
Deal found 7/26![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:14 am
BUF
- DSM
2 stops8h 11m
American Airlines
Sat 8/221:55 pm
DSM
- BUF
2 stops9h 01m
American Airlines
Deal found 7/26![American Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:50 am
BUF
- DSM
2 stops10h 55m
Southwest
Sat 8/295:30 am
DSM
- BUF
1 stop3h 40m
Southwest
Deal found 7/25![Southwest logo]()
$350
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:44 pm
BUF
- DSM
1 stop6h 57m
American Airlines
Thu 9/242:44 pm
DSM
- BUF
1 stop6h 26m
American Airlines
Deal found 7/25![American Airlines logo]()
$365
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:10 pm
BUF
- DSM
1 stop4h 00m
Southwest
Thu 9/35:40 am
DSM
- BUF
1 stop4h 05m
Southwest
Deal found 7/30![Southwest logo]()
$383
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/25:50 pm
BUF
- DSM
1 stop6h 11m
United Airlines
Sat 12/56:15 am
DSM
- BUF
1 stop5h 55m
United Airlines
Deal found 7/28![United Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/142:51 pm
BUF
- DSM
1 stop8h 15m
American Airlines
Tue 8/185:46 am
DSM
- BUF
1 stop4h 43m
American Airlines
Deal found 7/25![American Airlines logo]()
$411
Best flights from Buffalo to Des MoinesDiscover carefully curated flight deals from Buffalo to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
Discover carefully curated flight deals from Buffalo to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/224:54 pm
BUF
- DSM
1 stop4h 52m
American Airlines
Sat 8/291:09 pm
DSM
- BUF
1 stop4h 58m
American Airlines
Deal found 7/25![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:55 am
BUF
- DSM
1 stop4h 31m
United Airlines
Sat 8/225:45 am
DSM
- BUF
2 stops10h 07m
United Airlines
Deal found 7/26![United Airlines logo]()
$330
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:50 am
BUF
- DSM
2 stops10h 55m
Southwest
Sat 8/295:30 am
DSM
- BUF
1 stop3h 40m
Southwest
Deal found 7/25![Southwest logo]()
$350
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:10 pm
BUF
- DSM
1 stop4h 00m
Southwest
Thu 9/35:40 am
DSM
- BUF
1 stop4h 05m
Southwest
Deal found 7/30![Southwest logo]()
$383
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:00 am
BUF
- DSM
1 stop4h 20m
United Airlines
Sat 12/59:09 am
DSM
- BUF
2 stops12h 28m
United Airlines
Deal found 7/28![United Airlines logo]()
$410
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:18 pm
BUF
- DSM
2 stops7h 46m
American Airlines
Thu 9/247:00 am
DSM
- BUF
2 stops8h 21m
American Airlines
Deal found 7/28![American Airlines logo]()
$490
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/287:20 am
BUF
- DSM
1 stop5h 00m
Southwest
Sun 1/35:15 am
DSM
- BUF
1 stop3h 55m
Southwest
Deal found 7/28![Southwest logo]()
$477
Last-minute flights from Buffalo to Des MoinesDiscover last-minute flight deals from Buffalo to Des Moines. Data last updated July 30, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Des Moines. Data last updated July 30, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:50 am
BUF
- DSM
1 stop6h 34m
American Airlines
Sat 8/151:08 pm
DSM
- BUF
1 stop7h 47m
American Airlines
Deal found 7/27![American Airlines logo]()
$497
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:00 am
BUF
- DSM
2 stops9h 16m
United Airlines
Sat 8/1511:32 am
DSM
- BUF
1 stop4h 24m
United Airlines
Deal found 7/27![United Airlines logo]()
$502
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:00 am
BUF
- DSM
2 stops6h 50m
Southwest
Sat 8/1512:10 pm
DSM
- BUF
2 stops7h 55m
Southwest
Deal found 7/27![Southwest logo]()
$507
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/142:51 pm
BUF
- DSM
1 stop8h 15m
American Airlines
Tue 8/185:46 am
DSM
- BUF
1 stop4h 43m
American Airlines
Deal found 7/25![American Airlines logo]()
$411
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:55 am
BUF
- DSM
1 stop6h 25m
United Airlines
Sat 8/2211:32 am
DSM
- BUF
1 stop4h 20m
United Airlines
Deal found 7/26![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:14 am
BUF
- DSM
2 stops8h 11m
American Airlines
Sat 8/221:55 pm
DSM
- BUF
2 stops9h 01m
American Airlines
Deal found 7/26![American Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:50 am
BUF
- DSM
2 stops10h 55m
Southwest
Sat 8/295:30 am
DSM
- BUF
1 stop3h 40m
Southwest
Deal found 7/25![Southwest logo]()
$350
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:10 pm
BUF
- DSM
1 stop4h 00m
Southwest
Thu 9/35:40 am
DSM
- BUF
1 stop4h 05m
Southwest
Deal found 7/30![Southwest logo]()
$383
One-way flights from Buffalo to Des MoinesSearch for one-way flight options from Buffalo to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
Search for one-way flight options from Buffalo to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:29 pm
BUF
- DSM
2 stops36h 10m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$152
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:30 am
BUF
- DSM
1 stop4h 46m
United Airlines
Deal found 7/25![United Airlines logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/89:29 pm
BUF
- DSM
2 stops36h 10m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/612:11 pm
BUF
- DSM
2 stops36h 03m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$292
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/612:56 pm
BUF
- DSM
1 stop6h 45m
American Airlines
Deal found 7/25![American Airlines logo]()
$394
Find flight deals from Buffalo to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $325 (United Airlines) |
One-way from | $152 (Kiwi.com) |
Popular in | March |
Cheapest in | April |
Average price | $506 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Sat 8/22
4:54 pm-8:46 pm
1 stop4h 52m
Des Moines
Sat 8/29
1:09 pm-7:07 pm
1 stop4h 58m
$325
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Tue 8/18
6:55 am-10:26 am
1 stop4h 31m
Des Moines
Sat 8/22
5:45 am-4:52 pm
2 stops10h 07m
$330
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Sat 8/22
10:50 am-8:45 pm
2 stops10h 55m
Des Moines
Sat 8/29
5:30 am-10:10 am
1 stop3h 40m
$350
Quickest round-trip
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Thu 8/27
7:10 pm-10:10 pm
1 stop4h 00m
Des Moines
Thu 9/3
5:40 am-10:45 am
1 stop4h 05m
$383
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Wed 12/2
7:00 am-10:20 am
1 stop4h 20m
Des Moines
Sat 12/5
9:09 am-10:37 pm
2 stops12h 28m
$410
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Mon 12/28
7:20 am-11:20 am
1 stop5h 00m
Des Moines
Sun 1/3
5:15 am-10:10 am
1 stop3h 55m
$477
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Wed 9/23
5:18 pm-12:04 am
2 stops7h 46m
Des Moines
Thu 9/24
7:00 am-4:21 pm
2 stops8h 21m
$490
Cheapest one-way
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Tue 9/8
6:09 pm-12:20 am
1 stop7h 11m
$163
Quickest one-way
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Tue 9/1
10:30 am-2:16 pm
1 stop4h 46m
$163
BuffaloDes Moines
BUF - DSM
BUFDSM
Buffalo
Tue 9/8
9:29 pm-8:39 am
2 stops36h 10m
$166
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Des Moines in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Buffalo with our price prediction graph.
BUF-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 30, 2026.
Read through reviews of airlines operating flights from Buffalo to Des Moines, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Boarding
8.1
Overall
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Entertainment
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Boarding
8.1
Overall
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Entertainment
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Boarding
8.1
Overall
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Entertainment
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Boarding
8.1
Overall
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 30, 2026.
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Buffalo and Des Moines flights
Browse other Buffalo and Des Moines flight options. Last updated on July 30, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on July 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Buffalo to Des Moines
Discover the top 3 airlines that operate flights from Buffalo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$426 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$314 | Average$478 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$319 | Average$458 | FlexibilityNo cancel fee | On-timeN/A |