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Des Moines

$107+ Cheap flights from Buffalo to Des Moines (BUF - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/21. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — DSM
dic. 12 — dic. 191
vie. 12/12
vie. 12/19
1 adult, Economy
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Cheap flight deals from Buffalo to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated noviembre 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$317
(Delta)

One-way from

$159
(Delta)

Popular in

November

Cheapest in

June

Average price

$507
Provider with most accurate pricing for Buffalo-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Buffalo-Des Moines flights.
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From Buffalo to Des Moines
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One-way flight from Buffalo to Des Moines
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Highest demand for flights based on searches. 10% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Buffalo to Des Moines

Cheapest flights from Buffalo to Des Moines
Explore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 12, 2025.

This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/91:16 pmBUF - DSM
1 stop4h 00mDelta
vie. 12/1210:20 amDSM - BUF
1 stop5h 50mDelta
Deal found 11/11$352
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/96:00 amBUF - DSM
2 stops9h 20mUnited Airlines
vie. 12/128:00 amDSM - BUF
1 stop4h 12mUnited Airlines
Deal found 11/11$357
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/127:00 amBUF - DSM
1 stop4h 29mUnited Airlines
lun. 12/153:17 pmDSM - BUF
1 stop4h 58mUnited Airlines
Deal found 11/11$364
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/276:12 amBUF - DSM
1 stop4h 29mDelta
dom. 11/305:52 pmDSM - BUF
1 stop4h 05mDelta
Deal found 11/12$390
This Southwest deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/1212:45 pmBUF - DSM
2 stops11h 50mSouthwest
lun. 12/156:15 amDSM - BUF
2 stops6h 10mSouthwest
Deal found 11/11$431
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/256:10 amBUF - DSM
1 stop5h 32mDelta
sáb. 11/296:17 amDSM - BUF
1 stop5h 14mDelta
Deal found 11/10$467
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/277:00 amBUF - DSM
1 stop4h 42mUnited Airlines
lun. 12/16:50 pmDSM - BUF
2 stops18h 32mUnited Airlines
Deal found 11/12$556
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/257:00 amBUF - DSM
1 stop6h 14mUnited Airlines
sáb. 11/299:44 pmDSM - BUF
1 stop11h 19mUnited Airlines
Deal found 11/10$628
This Southwest deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/1612:40 pmBUF - DSM
2 stops11h 55mSouthwest
mar. 11/186:15 amDSM - BUF
2 stops6h 10mSouthwest
Deal found 11/12$637

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 12, 2025.
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.

Fly from

Buffalo

Fly to

Des Moines

Route

Depart

Return

Price

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

mar. 3/31

6:25 am-9:30 am

1 stop4h 05m

Des Moines

mié. 4/1

10:15 am-5:07 pm

1 stop5h 52m

$317

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

mar. 12/9

1:16 pm-4:16 pm

1 stop4h 00m

Des Moines

vie. 12/12

10:20 am-5:10 pm

1 stop5h 50m

$352

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

mié. 12/10

2:57 pm-7:43 pm

1 stop5h 46m

Des Moines

vie. 12/12

6:17 am-12:34 pm

1 stop5h 17m

$352

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

mar. 12/9

6:00 am-2:20 pm

2 stops9h 20m

Des Moines

vie. 12/12

8:00 am-1:12 pm

1 stop4h 12m

$357

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

vie. 12/12

7:00 am-10:29 am

1 stop4h 29m

Des Moines

lun. 12/15

3:17 pm-9:15 pm

1 stop4h 58m

$364

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

jue. 11/27

5:30 am-12:40 pm

1 stop8h 10m

Des Moines

lun. 12/1

4:03 pm-12:08 am

1 stop7h 05m

$390

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

jue. 11/27

6:12 am-9:41 am

1 stop4h 29m

Des Moines

dom. 11/30

5:52 pm-10:57 pm

1 stop4h 05m

$390

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

mar. 3/31

6:00 am-12:19 pm

2 stops7h 19m

Des Moines

mié. 4/1

2:48 pm-9:08 pm

1 stop5h 20m

$392

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

mié. 12/17

1:16 pm-4:16 pm

1 stop4h 00m

$159

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

mar. 12/16

6:00 am-1:31 pm

1 stop8h 31m

$159

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 19 results
1
2

Compare providers for flights from Buffalo to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Des Moines in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Buffalo-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Buffalo-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Des Moines

What is the cheapest month to book a flight from Buffalo to Des Moines?

Currently, June is the cheapest month in which you can book a flight from Buffalo to Des Moines (average of $119). Flying from Buffalo to Des Moines in January is currently the most expensive (average of $367). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated noviembre 12, 2025.
Read through reviews of airlines operating flights from Buffalo to Des Moines, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,009 reviews

Food

7.3

Comfort

7.9

Boarding

8.1

Crew

8.5

Overall

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,009 reviews
Delta
7.9
Good
8,009 reviews

Food

7.3

Comfort

7.9

Boarding

8.1

Crew

8.5

Overall

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,009 reviews

Food

7.3

Comfort

7.9

Boarding

8.1

Crew

8.5

Overall

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Des Moines?

    A quick flight from Buffalo to Des Moines can take about 4h 05m. Delta provides one of the quickest options available for as low as $317. The distance between Buffalo and Des Moines is about 768 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Buffalo to Des Moines round-trip?

    American Airlines, at $258, was found to be the cheapest airline from Buffalo to Des Moines. An alternate airline flying to your destination would be Delta. You may be able to fly from Buffalo to Des Moines for 35% less than the average price by searching for these airlines.

  • Can I find deals for flights from Buffalo to Des Moines that include hotel bookings?

    Yes. In addition to deals on Buffalo to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Des Moines.

  • Can I find deals for business class flights from Buffalo to Des Moines?

    Yes. Cheapflights offers flight deals from Buffalo to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Des Moines?

    Currently, June is the cheapest month in which you can book a flight from Buffalo to Des Moines (average of $119). Flying from Buffalo to Des Moines in January is currently the most expensive (average of $367). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Buffalo to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Buffalo to Des Moines

Discover the top 2 airlines that operate flights from Buffalo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$385FlexibilityNo cancel feeOn-time71%
DeltaCheapest$316Average$497FlexibilityNo cancel feeOn-timeN/A

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