$141+ Cheap flights from Buffalo to Des Moines (BUF - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — DSM
Nov 29 — Dec 61
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Buffalo to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Buffalo to Des MoinesExplore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:55 pm -
1 stop5h 48m
Sun 11/155:29 pm -
1 stop5h 29m
Deal found 10/26![Delta logo]()
$537
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1111:20 am -
2 stops11h 45m
Sun 11/155:25 am -
1 stop4h 00m
Deal found 10/26![Southwest logo]()
$542
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:05 pm -
2 stops12h 00m
Tue 11/176:00 am -
2 stops9h 30m
Deal found 10/29![Southwest logo]()
$547
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:51 am -
2 stops7h 37m
Sun 11/156:05 am -
2 stops7h 05m
Deal found 10/26![United Airlines logo]()
$548
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:25 am -
1 stop4h 35m
Wed 11/113:30 pm -
1 stop4h 25m
Deal found 10/26![Southwest logo]()
$693
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:34 am -
2 stops8h 19m
Wed 11/116:00 am -
1 stop4h 40m
Deal found 10/26![American Airlines logo]()
$698
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:30 am -
1 stop5h 02m
Wed 11/111:27 pm -
1 stop8h 06m
Deal found 10/29![United Airlines logo]()
$827
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:30 am -
1 stop11h 00m
Wed 11/43:30 pm -
1 stop4h 25m
Deal found 10/27![Southwest logo]()
$932
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:30 am -
2 stops11h 06m
Wed 11/46:05 am -
1 stop6h 12m
Deal found 10/27![United Airlines logo]()
$937
Best flights from Buffalo to Des MoinesDiscover carefully curated flight deals from Buffalo to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Buffalo to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:00 am -
1 stop5h 48m
Tue 11/179:25 am -
2 stops7h 00m
Deal found 10/29![American Airlines logo]()
$542
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1111:20 am -
2 stops11h 45m
Sun 11/155:25 am -
1 stop4h 00m
Deal found 10/26![Southwest logo]()
$542
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:51 am -
2 stops7h 37m
Sun 11/156:05 am -
2 stops7h 05m
Deal found 10/26![United Airlines logo]()
$548
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:05 pm -
2 stops12h 00m
Tue 11/176:00 am -
2 stops9h 30m
Deal found 10/29![Southwest logo]()
$547
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:30 am -
1 stop5h 02m
Wed 11/111:27 pm -
1 stop8h 06m
Deal found 10/29![United Airlines logo]()
$827
Last-minute flights from Buffalo to Des MoinesDiscover last-minute flight deals from Buffalo to Des Moines. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Des Moines. Data last updated October 30, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:30 am -
1 stop11h 00m
Wed 11/43:30 pm -
1 stop4h 25m
Deal found 10/27![Southwest logo]()
$932
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:30 am -
2 stops11h 06m
Wed 11/46:05 am -
1 stop6h 12m
Deal found 10/27![United Airlines logo]()
$937
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:25 am -
1 stop4h 35m
Wed 11/113:30 pm -
1 stop4h 25m
Deal found 10/26![Southwest logo]()
$693
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:34 am -
2 stops8h 19m
Wed 11/116:00 am -
1 stop4h 40m
Deal found 10/26![American Airlines logo]()
$698
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:30 am -
1 stop5h 02m
Wed 11/111:27 pm -
1 stop8h 06m
Deal found 10/29![United Airlines logo]()
$827
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:55 pm -
1 stop5h 48m
Sun 11/155:29 pm -
1 stop5h 29m
Deal found 10/26![Delta logo]()
$537
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1111:20 am -
2 stops11h 45m
Sun 11/155:25 am -
1 stop4h 00m
Deal found 10/26![Southwest logo]()
$542
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:51 am -
2 stops7h 37m
Sun 11/156:05 am -
2 stops7h 05m
Deal found 10/26![United Airlines logo]()
$548
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:05 pm -
2 stops12h 00m
Tue 11/176:00 am -
2 stops9h 30m
Deal found 10/29![Southwest logo]()
$547
One-way flights from Buffalo to Des MoinesSearch for one-way flight options from Buffalo to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Buffalo to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:35 am -
1 stop4h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Delta logo]()
$141
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/234:18 pm -
2 stops9h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![American Airlines logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:20 pm -
3 stops25h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Multiple Airlines logo]()
$310
Find flight deals from Buffalo to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $537 (Delta) |
One-way from | $141 (Delta) |
Popular in | March |
Cheapest in | September |
Average price | $616 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Mon 11/23
7:10 pm-11:05 pm
1 stop4h 55m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$141
Quickest round-trip
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Mon 11/23
6:35 am-9:44 am
1 stop4h 09m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$141
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Mon 11/23
7:52 am-1:28 pm
1 stop6h 36m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$141
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Mon 11/23
9:20 pm-9:47 pm
3 stops25h 27m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$388
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Fri 11/13
6:00 am-10:48 am
1 stop5h 48m
Des Moines
Tue 11/17
9:25 am-5:25 pm
2 stops7h 00m
$542
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Wed 11/11
11:20 am-10:05 pm
2 stops11h 45m
Des Moines
Sun 11/15
5:25 am-10:25 am
1 stop4h 00m
$542
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Fri 11/13
12:05 pm-11:05 pm
2 stops12h 00m
Des Moines
Tue 11/17
6:00 am-4:30 pm
2 stops9h 30m
$547
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Wed 11/11
10:51 am-5:28 pm
2 stops7h 37m
Des Moines
Sun 11/15
6:05 am-2:10 pm
2 stops7h 05m
$548
BuffaloDes Moines
BUF Buffalo - DSM Des Moines
BUFDSM
Buffalo
Tue 11/10
6:30 am-10:32 am
1 stop5h 02m
Des Moines
Wed 11/11
1:27 pm-10:33 pm
1 stop8h 06m
$827
Sorted by cheapest first
Compare providers for flights from Buffalo to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Buffalo with our price prediction graph.
BUF-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 30, 2026.
Read through reviews of airlines operating flights from Buffalo to Des Moines, such as Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.8
Food
7.2
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.8
Food
7.2
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.8
Food
7.2
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Des Moines flight routes
Flights by cabin class
Other flight options
Other flights from Buffalo
Popular flights
Alternative routes for Buffalo to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Search flights from Buffalo to Des Moines by cabin class
Find flights from Buffalo to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and Des Moines flights
Browse other Buffalo and Des Moines flight options. Last updated on October 30, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Buffalo to Des Moines
Discover the top 2 airlines that operate flights from Buffalo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$162 | Average$455 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$406 | Average$566 | FlexibilityNo cancel fee | On-time69% |