$269+ Cheap flights from Manchester, NH to Des Moines (MHT - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
MHT — DSM
Oct 17 — Oct 241
Round-trip
1 adult, Economy
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Find cheap flights from Manchester to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Manchester to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Manchester to Des MoinesExplore the most affordable flight options available from Manchester to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from Manchester to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:35 pm -
1 stop5h 25m
Thu 11/55:25 am -
1 stop10h 15m
Deal found 9/15![Southwest logo]()
$326
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:50 pm -
1 stop5h 15m
Mon 11/234:25 pm -
1 stop4h 35m
Deal found 9/15![Southwest logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/199:25 am -
2 stops9h 03m
Mon 11/2311:22 am -
2 stops11h 37m
Deal found 9/15![United Airlines logo]()
$389
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:35 am -
1 stop4h 45m
Fri 10/305:10 am -
1 stop4h 40m
Deal found 9/15![Southwest logo]()
$408
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:55 pm -
1 stop5h 20m
Sun 10/185:30 am -
2 stops8h 25m
Deal found 9/15![Southwest logo]()
$433
Best flights from Manchester to Des MoinesDiscover carefully curated flight deals from Manchester to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from Manchester to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:35 pm -
1 stop5h 25m
Thu 11/55:25 am -
1 stop10h 15m
Deal found 9/15![Southwest logo]()
$326
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/102:38 pm -
2 stops8h 17m
Wed 11/111:27 pm -
2 stops9h 32m
Deal found 9/16![United Airlines logo]()
$533
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:24 pm -
1 stop5h 56m
Thu 10/159:26 am -
1 stop13h 47m
Deal found 9/15![American Airlines logo]()
$543
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:55 pm -
1 stop5h 20m
Sun 10/185:30 am -
1 stop4h 45m
Deal found 9/15![Southwest logo]()
$458
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:25 am -
2 stops6h 45m
Thu 10/154:30 pm -
1 stop4h 25m
Deal found 9/15![Southwest logo]()
$547
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/39:25 am -
2 stops9h 23m
Tue 10/66:00 am -
2 stops12h 01m
Deal found 9/14![United Airlines logo]()
$607
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/39:25 am -
2 stops12h 36m
Fri 10/91:24 pm -
2 stops9h 32m
Deal found 9/14![United Airlines logo]()
$607
Last-minute flights from Manchester to Des MoinesDiscover last-minute flight deals from Manchester to Des Moines. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from Manchester to Des Moines. Data last updated September 17, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:04 pm -
1 stop7h 37m
Sat 10/103:01 pm -
1 stop5h 43m
Deal found 9/14![American Airlines logo]()
$587
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:59 pm -
1 stop7h 05m
Wed 10/72:01 pm -
2 stops9h 22m
Deal found 9/14![American Airlines logo]()
$502
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:24 pm -
2 stops21h 11m
Fri 10/93:04 pm -
1 stop17h 11m
Deal found 9/14![Multiple Airlines logo]()
$491
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:24 pm -
1 stop5h 56m
Thu 10/159:26 am -
1 stop13h 47m
Deal found 9/15![American Airlines logo]()
$543
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:25 am -
2 stops6h 45m
Thu 10/154:30 pm -
1 stop4h 25m
Deal found 9/15![Southwest logo]()
$547
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:55 pm -
1 stop5h 20m
Sun 10/185:30 am -
2 stops8h 25m
Deal found 9/15![Southwest logo]()
$433
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:35 am -
1 stop4h 45m
Fri 10/305:10 am -
1 stop4h 40m
Deal found 9/15![Southwest logo]()
$408
One-way flights from Manchester to Des MoinesSearch for one-way flight options from Manchester to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
Search for one-way flight options from Manchester to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:52 pm -
1 stop7h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:25 am -
3 stops12h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![United Airlines logo]()
$680
Find flight deals from Manchester to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Manchester (MHT) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $326 (Southwest) |
One-way from | $269 (American Airlines) |
Popular in | February |
Cheapest in | April |
Average price | $431 |
Cheapflights Fare Finder
Customize your flight search to find flights from Manchester to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from Manchester to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ManchesterDes Moines
MHT Manchester - DSM Des Moines
MHTDSM
Manchester
Fri 10/2
2:52 pm-12:04 am
2 stops10h 12m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$274
ManchesterDes Moines
MHT Manchester - DSM Des Moines
MHTDSM
Manchester
Mon 11/2
6:35 pm-11:00 pm
1 stop5h 25m
Des Moines
Thu 11/5
5:25 am-4:40 pm
1 stop10h 15m
$326
Quickest round-trip
ManchesterDes Moines
MHT Manchester - DSM Des Moines
MHTDSM
Manchester
Fri 10/16
6:55 pm-11:15 pm
1 stop5h 20m
Des Moines
Sun 10/18
5:30 am-11:15 am
1 stop4h 45m
$458
ManchesterDes Moines
MHT Manchester - DSM Des Moines
MHTDSM
Manchester
Tue 11/10
2:38 pm-9:55 pm
2 stops8h 17m
Des Moines
Wed 11/11
1:27 pm-11:59 pm
2 stops9h 32m
$533
ManchesterDes Moines
MHT Manchester - DSM Des Moines
MHTDSM
Manchester
Fri 10/9
5:24 pm-10:20 pm
1 stop5h 56m
Des Moines
Thu 10/15
9:26 am-12:13 am
1 stop13h 47m
$543
ManchesterDes Moines
MHT Manchester - DSM Des Moines
MHTDSM
Manchester
Fri 10/9
5:25 am-11:10 am
2 stops6h 45m
Des Moines
Thu 10/15
4:30 pm-9:55 pm
1 stop4h 25m
$547
ManchesterDes Moines
MHT Manchester - DSM Des Moines
MHTDSM
Manchester
Sat 10/3
9:25 am-5:48 pm
2 stops9h 23m
Des Moines
Tue 10/6
6:00 am-7:01 pm
2 stops12h 01m
$607
ManchesterDes Moines
MHT Manchester - DSM Des Moines
MHTDSM
Manchester
Sat 10/3
9:25 am-9:01 pm
2 stops12h 36m
Des Moines
Fri 10/9
1:24 pm-11:56 pm
2 stops9h 32m
$607
ManchesterDes Moines
MHT Manchester - DSM Des Moines
MHTDSM
Manchester
Fri 10/2
9:25 am-9:23 pm
3 stops12h 58m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$680
Sorted by cheapest first
Compare providers for flights from Manchester to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Manchester to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Manchester, New Hampshire-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Manchester, New Hampshire-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Manchester, New Hampshire-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Manchester, New Hampshire-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Manchester, New Hampshire-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Manchester to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Manchester with our price prediction graph.
MHT-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 17, 2026.
Get a feel of what it's like to fly with Southwest and American Airlines from Manchester to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Boarding
8.1
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Boarding
8.1
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Boarding
8.1
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Manchester to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
West Des Moines
Boone
Norwalk
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 17, 2026.
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Manchester and Des Moines flights
Browse other Manchester and Des Moines flight options. Last updated on September 17, 2026.
Other flights from Manchester
Browse through other flights departing from Manchester. Flights are based on user searches made on Cheapflights and were last updated on September 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Manchester to Des Moines
Discover the top 2 airlines that operate flights from Manchester to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$355 | Average$586 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$379 | Average$512 | FlexibilityNo cancel fee | On-time71% |