HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$176+ Cheap flights from Portland, ME to Des Moines (PWM - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/17. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — DSM
May 28 — Jun 41
Thu 5/28
Thu 6/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Portland to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Portland to Des Moines

Cheapest flights from Portland to Des Moines
Explore the most affordable flight options available from Portland to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.

This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:17 pm
PWM
-
DSM
1 stop7h 33m
American Airlines
Sat 5/305:00 am
DSM
-
PWM
1 stop5h 03m
American Airlines
Deal found 4/26$378
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:58 pm
PWM
-
DSM
1 stop7h 12m
American Airlines
Sat 6/276:32 pm
DSM
-
PWM
1 stop5h 21m
American Airlines
Deal found 4/28$389
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:15 am
PWM
-
DSM
2 stops9h 50m
United Airlines
Mon 8/173:24 pm
DSM
-
PWM
1 stop5h 37m
United Airlines
Deal found 4/25$394
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/169:40 am
PWM
-
DSM
1 stop5h 44m
United Airlines
Sat 5/301:18 pm
DSM
-
PWM
1 stop7h 33m
United Airlines
Deal found 4/25$405
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
PWM
-
DSM
1 stop6h 08m
Delta
Thu 6/411:57 am
DSM
-
PWM
2 stops11h 46m
Delta
Deal found 4/28$410
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:17 pm
PWM
-
DSM
1 stop7h 33m
American Airlines
Fri 6/51:37 pm
DSM
-
PWM
1 stop8h 09m
American Airlines
Deal found 4/27$416
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:03 am
PWM
-
DSM
2 stops12h 29m
Delta
Sat 5/304:00 pm
DSM
-
PWM
1 stop6h 09m
Delta
Deal found 4/26$420
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/151:12 pm
PWM
-
DSM
1 stop7h 03m
Delta
Sun 7/192:25 pm
DSM
-
PWM
1 stop7h 49m
Delta
Deal found 4/28$427
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:05 pm
PWM
-
DSM
1 stop5h 07m
United Airlines
Wed 9/211:23 am
DSM
-
PWM
1 stop5h 21m
United Airlines
Deal found 4/26$441

Find flight deals from Portland to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Portland (PWM) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$378
(American Airlines)

One-way from

$176
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$444
Provider with most accurate pricing for Portland-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Portland-Des Moines flights.
Search Deals
From Portland to Des Moines
Search Deals
One-way flight from Portland to Des Moines
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($71 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Portland to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Portland to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 5/27

5:17 pm-11:50 pm

1 stop7h 33m

Des Moines

Sat 5/30

5:00 am-11:03 am

1 stop5h 03m

$378

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Sat 5/16

9:40 am-2:24 pm

1 stop5h 44m

Des Moines

Sat 5/30

1:18 pm-9:51 pm

1 stop7h 33m

$405

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Thu 6/4

6:02 am-1:37 pm

2 stops8h 35m

Des Moines

Mon 6/8

6:08 am-11:55 am

1 stop4h 47m

$410

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Mon 6/1

5:17 pm-11:50 pm

1 stop7h 33m

Des Moines

Fri 6/5

1:37 pm-10:46 pm

1 stop8h 09m

$416

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Thu 5/28

12:19 pm-6:36 pm

1 stop7h 17m

Des Moines

Thu 6/4

1:37 pm-10:46 pm

1 stop8h 09m

$416

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Tue 9/1

5:15 am-4:13 pm

2 stops11h 58m

Des Moines

Wed 9/2

8:00 am-2:28 pm

1 stop5h 28m

$446

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 7/15

6:00 am-1:34 pm

2 stops8h 34m

Des Moines

Sun 7/19

2:25 pm-11:14 pm

1 stop7h 49m

$456

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Sat 5/23

6:00 am-10:27 am

1 stop5h 27m

Des Moines

Wed 5/27

6:00 am-2:26 pm

1 stop7h 26m

$468
Cheapest one-way

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 6/17

6:00 am-1:35 pm

2 stops8h 35m

$181
Quickest one-way

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Sat 8/1

6:00 am-12:56 pm

1 stop7h 56m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Sorted by cheapest first

Compare providers for flights from Portland to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to Des Moines in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Portland, Maine-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Portland, Maine-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Portland, Maine-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Portland, Maine-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland, Maine-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Portland to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Des Moines

How much does it cost to fly round-trip from Portland, Maine to Des Moines?

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 28, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Portland to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,467 reviews

Comfort

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,467 reviews
Delta
7.9
Good
8,467 reviews

Comfort

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,672 reviews
Delta
7.9
Good
8,467 reviews

Comfort

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,677 reviews
Delta
7.9
Good
8,467 reviews

Comfort

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Portland to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Portland, Maine to Des Moines?

    For as low as $405, American Airlines can have you in Des Moines from Portland, Maine in 5h 44m. Airlines will cover a distance of 1192 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Portland, Maine to Des Moines round-trip?

    According to our current data, Delta ($193), American Airlines ($249), and United Airlines ($328) offers the cheapest pricing from Portland, Maine to Des Moines. You may be able to fly from Portland, Maine to Des Moines for 56% less than the average price by searching for these airlines.

  • Can I find deals for flights from Portland to Des Moines that include hotel bookings?

    Yes. In addition to deals on Portland to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Des Moines.

  • Can I find deals for business class flights from Portland to Des Moines?

    Yes. Cheapflights offers flight deals from Portland to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Portland to Des Moines

Discover the top 3 airlines that operate flights from Portland to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$193Average$384FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$249Average$474FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$328Average$485FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.